Lamp-2

Summary

Gene Symbol: Lamp-2
Description: lysosomal associated membrane protein 2
Alias: CD107b, LAMP-2, LAMPB, LGP-96, LGP110, lysosome-associated membrane glycoprotein 2, CD107 antigen-like family member B
Species: human
Products:     Lamp-2

Top Publications

  1. Konecki D, Foetisch K, Zimmer K, Schlotter M, Lichter Konecki U. An alternatively spliced form of the human lysosome-associated membrane protein-2 gene is expressed in a tissue-specific manner. Biochem Biophys Res Commun. 1995;215:757-67 pubmed
    ..Immune electron microscopy studies verified localization of this alternative gene product to the lysosomal membrane. ..
  2. Demirel O, Jan I, Wolters D, Blanz J, Saftig P, Tampe R, et al. The lysosomal polypeptide transporter TAPL is stabilized by interaction with LAMP-1 and LAMP-2. J Cell Sci. 2012;125:4230-40 pubmed publisher
    ..Reduced stability of TAPL is caused by increased lysosomal degradation, indicating that LAMP proteins retain TAPL on the limiting membrane of endosomes and prevent its sorting to intraluminal vesicles...
  3. Cuervo A, Stefanis L, Fredenburg R, Lansbury P, Sulzer D. Impaired degradation of mutant alpha-synuclein by chaperone-mediated autophagy. Science. 2004;305:1292-5 pubmed
    ..These findings may underlie the toxic gain-of-function by the mutants. ..
  4. Zhou D, Li P, Lin Y, Lott J, Hislop A, Canaday D, et al. Lamp-2a facilitates MHC class II presentation of cytoplasmic antigens. Immunity. 2005;22:571-81 pubmed
    ..These results demonstrate a novel role for the lysosomal Lamp-2a-hsc70 complex in promoting immunological recognition and antigen presentation...
  5. Shimada Sugawara M, Sakai E, Okamoto K, Fukuda M, Izumi T, Yoshida N, et al. Rab27A regulates transport of cell surface receptors modulating multinucleation and lysosome-related organelles in osteoclasts. Sci Rep. 2015;5:9620 pubmed publisher
    ..Thus, these findings suggest that Rab27A regulates normal transport of cell surface receptors modulating multinucleation and LROs in OCLs. ..
  6. Qiao S, Sun Y, Sun B, Wang A, Qiu J, Hong L, et al. Sevoflurane postconditioning protects against myocardial ischemia/reperfusion injury by restoring autophagic flux via an NO-dependent mechanism. Acta Pharmacol Sin. 2019;40:35-45 pubmed publisher
    ..The same results were also observed in a rat model of myocardial I/R injury ex vivo, suggesting that SPC protects rat hearts against myocardial reperfusion injury by restoring I/R-impaired autophagic flux via an NO-dependent mechanism. ..
  7. Burgeiro A, Fonseca A, Espinoza D, Carvalho L, Lourenco N, Antunes M, et al. Proteostasis in epicardial versus subcutaneous adipose tissue in heart failure subjects with and without diabetes. Biochim Biophys Acta Mol Basis Dis. 2018;1864:2183-2198 pubmed publisher
    ..UPR and autophagy are increased in EAT compared to SAT, opening doors to the identification of early biomarkers for cardiomyopathies and novel therapeutic targets. ..
  8. Hwang J. Effects of obesity on protein kinase C, brain creatine kinase, transcription, and autophagy in cochlea. Metab Brain Dis. 2017;32:735-742 pubmed publisher
    ..These results suggest that DIO might exacerbate hearing degeneration possibly via increased HDAC1 gene expression in the cochlea of CD/1 mice. ..
  9. Santos Llamas A, Monte M, Marin J, Perez M. Dysregulation of autophagy in rat liver with mitochondrial DNA depletion induced by the nucleoside analogue zidovudine. Arch Toxicol. 2018;92:2109-2118 pubmed publisher

More Information

Publications145 found, 100 shown here

  1. Sun Y, Liou B, Ran H, Skelton M, Williams M, Vorhees C, et al. Neuronopathic Gaucher disease in the mouse: viable combined selective saposin C deficiency and mutant glucocerebrosidase (V394L) mice with glucosylsphingosine and glucosylceramide accumulation and progressive neurological deficits. Hum Mol Genet. 2010;19:1088-97 pubmed publisher
  2. Luciano Mateo F, Cabré N, Fernández Arroyo S, Baiges Gaya G, Hernández Aguilera A, Rodríguez Tomàs E, et al. Chemokine (C-C motif) ligand 2 gene ablation protects low-density lipoprotein and paraoxonase-1 double deficient mice from liver injury, oxidative stress and inflammation. Biochim Biophys Acta Mol Basis Dis. 2019;: pubmed publisher
  3. Schiattarella G, Cerulo G, De Pasquale V, Cocchiaro P, Paciello O, Avallone L, et al. The Murine Model of Mucopolysaccharidosis IIIB Develops Cardiopathies over Time Leading to Heart Failure. PLoS ONE. 2015;10:e0131662 pubmed publisher
    ..Overall, our findings demonstrate that NAGLU(-/-) mice develop heart disease, valvular abnormalities and cardiac failure associated with an impaired lysosomal autophagic flux. ..
  4. Ling H, Chen H, Wei M, Meng X, Yu Y, Xie K. The Effect of Autophagy on Inflammation Cytokines in Renal Ischemia/Reperfusion Injury. Inflammation. 2016;39:347-356 pubmed publisher
  5. Qadir F, Aziz M, Sari C, Ma H, Dai H, Wang X, et al. Transcriptome reprogramming by cancer exosomes: identification of novel molecular targets in matrix and immune modulation. Mol Cancer. 2018;17:97 pubmed publisher
    ..Molecular pathways and biomarkers identified in this study may be clinically exploitable for developing novel liquid-biopsy based diagnostics and immunotherapies. ..
  6. Wohlgemuth S, Lees H, Marzetti E, Manini T, Aranda J, Daniels M, et al. An exploratory analysis of the effects of a weight loss plus exercise program on cellular quality control mechanisms in older overweight women. Rejuvenation Res. 2011;14:315-24 pubmed publisher
    ..In conclusion, although exploratory in nature, this study is among the first to report the stimulation of cellular quality control mechanisms elicited by a weight loss and exercise program in older obese women. ..
  7. Yu Y, YU Y, Zhang Y, Zhang Z, An W, Zhao X. Treatment with D-β-hydroxybutyrate protects heart from ischemia/reperfusion injury in mice. Eur J Pharmacol. 2018;829:121-128 pubmed publisher
    ..Furthermore, treatment of I/R mice with BHB abated oxidative stress and attenuated endoplasmic reticulum stress in myocardium. Our results indicated that treatment with exogenous BHB protected heart from I/R injury in mice. ..
  8. Cho H, Choi J, Lee S. Impairment of autophagosome-lysosome fusion contributes to chronic ethanol-induced liver injury. Alcohol. 2014;48:717-25 pubmed publisher
    ..Taken together, these findings suggest that chronic ethanol consumption leads to impairment of autophagic flux, which contributes to ethanol-induced liver injury. ..
  9. Giegerich A, Kuchler L, Sha L, Knape T, Heide H, Wittig I, et al. Autophagy-dependent PELI3 degradation inhibits proinflammatory IL1B expression. Autophagy. 2014;10:1937-52 pubmed publisher
    ..Our observations suggest that autophagy causes PELI3 degradation during TLR4-signaling, thereby impairing the hyperinflammatory phase during sepsis. ..
  10. Ito A, Fukaya M, Saegusa S, Kobayashi E, Sugawara T, Hara Y, et al. Pallidin is a novel interacting protein for cytohesin-2 and regulates the early endosomal pathway and dendritic formation in neurons. J Neurochem. 2018;147:153-177 pubmed publisher
    ..Cover Image for this issue: doi: 10.1111/jnc.14197. ..
  11. Huang L, Yuan P, Yu P, Kong Q, Xu Z, Yan X, et al. O-GlcNAc-modified SNAP29 inhibits autophagy-mediated degradation via the disturbed SNAP29-STX17-VAMP8 complex and exacerbates myocardial injury in type I diabetic rats. Int J Mol Med. 2018;42:3278-3290 pubmed publisher
  12. Hung T, Yuan R, Huang W, Chen Y, Lin Y, Lin C, et al. Increased Autophagy Markers Are Associated with Ductular Reaction during the Development of Cirrhosis. Am J Pathol. 2015;185:2454-67 pubmed publisher
    ..In conclusion, we demonstrated that increased autophagy marker positively correlated with DR during the development of cirrhosis. Therefore, targeting autophagy may hold therapeutic value for liver cirrhosis. ..
  13. Yin Y, Li E, Sun G, Yan H, Foley L, Andrzejczuk L, et al. Effects of DHA on Hippocampal Autophagy and Lysosome Function After Traumatic Brain Injury. Mol Neurobiol. 2018;55:2454-2470 pubmed publisher
    ..Swift post-injury DHA administration restores hippocampal lysosomal biogenesis and function, demonstrating its therapeutic potential. ..
  14. Liu H, Jiang W, Chen X, Chang G, Zhao L, Li X, et al. Skeletal muscle-specific Sidt2 knockout in mice induced muscular dystrophy-like phenotype. Metabolism. 2018;85:259-270 pubmed publisher
    ..We concluded that Sidt2 deficiency leads to muscular dystrophy-like phenotype in mice and Sidt2 plays a critical role in the late stage of autophagy. ..
  15. Cui X, Liu H, Li J, Guo K, Han W, Dong Y, et al. Heat shock factor 4 regulates lens epithelial cell homeostasis by working with lysosome and anti-apoptosis pathways. Int J Biochem Cell Biol. 2016;79:118-127 pubmed publisher
  16. Lina T, Luo T, Velayutham T, Das S, McBride J. Ehrlichia Activation of Wnt-PI3K-mTOR Signaling Inhibits Autolysosome Generation and Autophagic Destruction by the Mononuclear Phagocyte. Infect Immun. 2017;85: pubmed publisher
    ..This report reveals Ehrlichia exploitation of the evolutionarily conserved Wnt pathway to inhibit autolysosome generation, thereby leading to evasion of this important innate immune defense mechanism. ..
  17. Xu J, Liu F, Li W, Zhao Y, Zhao D, Luo Y, et al. Cylindrical Spirals in Skeletal Muscles Originate From the Longitudinal Sarcoplasmic Reticulum. J Neuropathol Exp Neurol. 2016;75:148-55 pubmed
    ..Immunochemical staining with antibodies against calsequestrin and RYR1 help to distinguish these 2 pathological alterations. ..
  18. Zhao K, Hao H, Liu J, Tong C, Cheng Y, Xie Z, et al. Bone marrow-derived mesenchymal stem cells ameliorate chronic high glucose-induced β-cell injury through modulation of autophagy. Cell Death Dis. 2015;6:e1885 pubmed publisher
    ..This study unveiled novel evidence of BM-MSCs as an ideal strategy to enhance autophagy for treatment of T2D mellitus. ..
  19. Kayama Y, Shibata M, Takizawa T, Ibata K, Nakahara J, Shimizu T, et al. Signaling Pathways Relevant to Nerve Growth Factor-induced Upregulation of Transient Receptor Potential M8 Expression. Neuroscience. 2017;367:178-188 pubmed publisher
    ..Our findings provide novel insight into the signaling pathways involved in NGF-mediated TRPM8 upregulation and its reversion to the normal state. ..
  20. Parks A, Charest Morin X, Boivin Welch M, Bouthillier J, Marceau F. Autophagic flux inhibition and lysosomogenesis ensuing cellular capture and retention of the cationic drug quinacrine in murine models. Peerj. 2015;3:e1314 pubmed publisher
    ..As shown in vitro and in vivo, V-ATPase-mediated cation sequestration is associated, above a certain threshold, to autophagic flux inhibition and feed-back lysosomogenesis. ..
  21. Kang K, Shin J, Lee S. Pterostilbene protects against acetaminophen-induced liver injury by restoring impaired autophagic flux. Food Chem Toxicol. 2019;123:536-545 pubmed publisher
    ..Our findings suggest that PTE protects against APAP-induced hepatotoxicity by enhancing autophagic flux. ..
  22. Leow S, Chua S, Venkatachalam G, Shen L, Luo L, Clement M. Sub-lethal oxidative stress induces lysosome biogenesis via a lysosomal membrane permeabilization-cathepsin-caspase 3-transcription factor EB-dependent pathway. Oncotarget. 2017;8:16170-16189 pubmed publisher
  23. Marsch E, Theelen T, Demandt J, Jeurissen M, van Gink M, Verjans R, et al. Reversal of hypoxia in murine atherosclerosis prevents necrotic core expansion by enhancing efferocytosis. Arterioscler Thromb Vasc Biol. 2014;34:2545-53 pubmed publisher
    ..cell content (-50%) and increased efferocytosis of apoptotic cells by cluster of differentiation 107b(+) (CD107b, MAC3) macrophages (+36%) in advanced plaques of the aortic root...
  24. Horibe A, Eid N, Ito Y, Hamaoka H, Tanaka Y, Kondo Y. Upregulated Autophagy in Sertoli Cells of Ethanol-Treated Rats Is Associated with Induction of Inducible Nitric Oxide Synthase (iNOS), Androgen Receptor Suppression and Germ Cell Apoptosis. Int J Mol Sci. 2017;18: pubmed publisher
    ..The results highlighted the molecular mechanisms of prosurvival autophagy in ETR SCs for the first time, and may have significant implications for male fertility. ..
  25. Kondo T, Namiki T, Coelho S, Valencia J, Hearing V. Oculocutaneous albinism: developing novel antibodies targeting the proteins associated with OCA2 and OCA4. J Dermatol Sci. 2015;77:21-7 pubmed publisher
    ..These results provide a basis to understand how disrupted functions of P or MATP result in the misrouting of tyrosinase and cause the hypopigmentation seen in OCA2 and OCA4. ..
  26. Shin J, Kang J, Lee S. Enhanced nitric oxide-mediated autophagy contributes to the hepatoprotective effects of ischemic preconditioning during ischemia and reperfusion. Nitric Oxide. 2016;58:10-9 pubmed publisher
    ..IPC also augmented the level of phosphorylated p38 MAPK induced by I/R and this phosphorylation was abolished by L-NAME. Our findings suggest that IPC-mediated NO protects against I/R-induced liver injury by enhancing autophagic flux. ..
  27. Jin L, Feng T, Chai J, Ghazalli N, Gao D, Zerda R, et al. Colony-forming progenitor cells in the postnatal mouse liver and pancreas give rise to morphologically distinct insulin-expressing colonies in 3D cultures. Rev Diabet Stud. 2014;11:35-50 pubmed publisher
    ..Postnatal liver CFU-Dark display a cell surface marker CD133⁺CD49f(low)CD107b(low) phenotype, while pancreatic CFU-Dark are CD133⁻...
  28. Yamamoto J, Kamata S, Miura A, Nagata T, Kainuma R, Ishii I. Differential adaptive responses to 1- or 2-day fasting in various mouse tissues revealed by quantitative PCR analysis. FEBS Open Bio. 2015;5:357-68 pubmed publisher
  29. Chhangani D, Endo F, Amanullah A, Upadhyay A, Watanabe S, Mishra R, et al. Mahogunin ring finger 1 confers cytoprotection against mutant SOD1 aggresomes and is defective in an ALS mouse model. Neurobiol Dis. 2016;86:16-28 pubmed publisher
    ..Furthermore, the present study identifies the MGRN1-mediated protein QC mechanism as a novel therapeutic target in neurodegenerative diseases. ..
  30. Demarest T, Waite E, Kristian T, Puche A, Waddell J, McKenna M, et al. Sex-dependent mitophagy and neuronal death following rat neonatal hypoxia-ischemia. Neuroscience. 2016;335:103-13 pubmed publisher
    ..The deficit in elimination of damaged/dysfunctional mitochondria in the male brain following HI may contribute to male vulnerability to neuronal death and long-term neurobehavioral deficits following HIE. ..
  31. Wiedmer T, Blank A, Pantasis S, Normand L, Bill R, Krebs P, et al. Autophagy Inhibition Improves Sunitinib Efficacy in Pancreatic Neuroendocrine Tumors via a Lysosome-dependent Mechanism. Mol Cancer Ther. 2017;16:2502-2515 pubmed publisher
    ..We suggest that adding chloroquine to sunitinib treatment will increase efficacy of PanNET treatment and that such patients should be included in respective ongoing clinical trials. Mol Cancer Ther; 16(11); 2502-15. ©2017 AACR. ..
  32. Marycz K, Kornicka K, Grzesiak J, Smieszek A, Szłapka J. Macroautophagy and Selective Mitophagy Ameliorate Chondrogenic Differentiation Potential in Adipose Stem Cells of Equine Metabolic Syndrome: New Findings in the Field of Progenitor Cells Differentiation. Oxid Med Cell Longev. 2016;2016:3718468 pubmed publisher
    ..Our data indicates that autophagy in ASCEMS would be crucial for the quality control mechanisms and maintenance of cellular homeostasis ASCEMS allowing them to be in "stemness" status. ..
  33. Hua R, Han S, Zhang N, Dai Q, Liu T, Li J. cPKC?-Modulated Sequential Reactivation of mTOR Inhibited Autophagic Flux in Neurons Exposed to Oxygen Glucose Deprivation/Reperfusion. Int J Mol Sci. 2018;19: pubmed publisher
    ..cPKCγ-modulated sequential reactivation of mTOR inhibited autophagic flux in neurons exposed to OGD/R, which may provide endogenous interventional strategies for stroke, especially ischemia/reperfusion injury. ..
  34. Sabe A, Elmadhun N, Sadek A, Chu L, Bianchi C, Sellke F. Differential effects of atorvastatin on autophagy in ischemic and nonischemic myocardium in Ossabaw swine with metabolic syndrome. J Thorac Cardiovasc Surg. 2014;148:3172-8 pubmed publisher
    ..The differential regulation on autophagy may, in part, explain the cardioprotective effect of statins in both ischemic and nonischemic myocardia, and these findings may have implications in the setting of cardiac surgery. ..
  35. Harris White M, Ferbas K, Johnson M, Eslami P, Poteshkina A, Venkova K, et al. A cell-penetrating ester of the neural metabolite lanthionine ketimine stimulates autophagy through the mTORC1 pathway: Evidence for a mechanism of action with pharmacological implications for neurodegenerative pathologies. Neurobiol Dis. 2015;84:60-8 pubmed publisher
    ..These findings clarify the mechanism-of-action for LKE in preclinical models of CNS disease, while suggesting possible roles for natural lanthionine metabolites in regulating CNS autophagy. ..
  36. Pang S, Chen D, Zhang A, Qin X, Yan B. Genetic analysis of the LAMP-2 gene promoter in patients with sporadic Parkinson's disease. Neurosci Lett. 2012;526:63-7 pubmed publisher
    ..4760T>G), was observed between PD patients and controls. Collectively, the sequence variants within the LAMP-2 gene promoter may be linked to the PD onset by changing LAMP-2 protein levels and impairing autophagy and CMA activities. ..
  37. Marino M, Musumeci O, Paleologo G, Cucinotta M, Migliorato A, Rodolico C, et al. Ischemic stroke due to hypoperfusion in a patient with a previously unrecognized Danon disease. Neuromuscul Disord. 2016;26:890-894 pubmed publisher
    ..LAMP2 molecular analysis identified a "de novo" mutation (p. Q353X). This patient with a neglected Danon disease, experienced an unusual complication as a stroke due to cerebral hypoperfusion after cardiac arrest caused by WPW syndrome. ..
  38. Qi L, Zhang X, Wu J, Lin F, Wang J, DiFiglia M, et al. The role of chaperone-mediated autophagy in huntingtin degradation. PLoS ONE. 2012;7:e46834 pubmed publisher
    ..These studies suggest that Hsc70 and LAMP-2A through CMA play a role in the clearance of Htt and suggest a novel strategy to target the degradation of mutant Htt. ..
  39. Fowler D, Copier J, Dalgleish A, Bodman Smith M. Zoledronic acid renders human M1 and M2 macrophages susceptible to V?2+ ?? T cell cytotoxicity in a perforin-dependent manner. Cancer Immunol Immunother. 2017;66:1205-1215 pubmed publisher
    ..T cells expressed perforin and degranulated in response to ZA-treated M?s as shown by mobilisation of CD107a and CD107b to the cell surface...
  40. Furuta K, Yang X, Chen J, Hamilton S, August J. Differential expression of the lysosome-associated membrane proteins in normal human tissues. Arch Biochem Biophys. 1999;365:75-82 pubmed
    ..Our studies of these molecules in human tissues support the conclusion that the expression of the molecules is independently controlled in some tissues, suggesting that the molecules may have independent as well as similar functions. ..
  41. Piedrahita D, Castro Álvarez J, Boudreau R, Villegas Lanau A, Kosik K, Gallego Gómez J, et al. β-Secretase 1's Targeting Reduces Hyperphosphorilated Tau, Implying Autophagy Actors in 3xTg-AD Mice. Front Cell Neurosci. 2015;9:498 pubmed publisher
    ..In summary, our findings suggest that BACE1 silencing neuroprotects reducing soluble hyperphosphorylated tau, modulating certain autophagy-related proteins in aged 3xTg-AD mice. ..
  42. Parcon P, Balasubramaniam M, Ayyadevara S, Jones R, Liu L, Shmookler Reis R, et al. Apolipoprotein E4 inhibits autophagy gene products through direct, specific binding to CLEAR motifs. Alzheimers Dement. 2018;14:230-242 pubmed publisher
    ..ApoE4-CLEAR interactions may account for suppressed autophagy in APOE ɛ4/ɛ4 carriers and, in this way, contribute to earlier AD onset. ..
  43. Chang M, Karageorgos L, Meikle P. CD107a (LAMP-1) and CD107b (LAMP-2). J Biol Regul Homeost Agents. 2002;16:147-51 pubmed
  44. Doehle B, Chang K, Rustagi A, McNevin J, McElrath M, Gale M. Vpu mediates depletion of interferon regulatory factor 3 during HIV infection by a lysosome-dependent mechanism. J Virol. 2012;86:8367-74 pubmed publisher
    ..These observations define the Vpu-IRF3 interface as a novel target for therapeutic strategies aimed at enhancing the immune response to HIV. ..
  45. Cheng S, Wani W, Hottman D, Jeong A, Cao D, LeBlanc K, et al. Haplodeficiency of Cathepsin D does not affect cerebral amyloidosis and autophagy in APP/PS1 transgenic mice. J Neurochem. 2017;142:297-304 pubmed publisher
  46. Musumeci O, Rodolico C, Nishino I, Di Guardo G, Migliorato A, Aguennouz M, et al. Asymptomatic hyperCKemia in a case of Danon disease due to a missense mutation in Lamp-2 gene. Neuromuscul Disord. 2005;15:409-11 pubmed
    ..This is the first missense mutation so far described. LAMP-2 deficiency should be considered as a cause of recurrent hyperCKemia and hypertrophic cardiomyopathy. ..
  47. Kuang E, Okumura C, Sheffy Levin S, Varsano T, Shu V, Qi J, et al. Regulation of ATG4B stability by RNF5 limits basal levels of autophagy and influences susceptibility to bacterial infection. PLoS Genet. 2012;8:e1003007 pubmed publisher
    ..Collectively, the RNF5-mediated control of membranalATG4B reveals a novel layer in the regulation of LC3 processing and autophagy. ..
  48. Zhu Y, Zheng M, Song D, Ye L, Wang X. Global comparison of chromosome X genes of pulmonary telocytes with mesenchymal stem cells, fibroblasts, alveolar type II cells, airway epithelial cells, and lymphocytes. J Transl Med. 2015;13:318 pubmed publisher
  49. Singh V, Finke Isami J, Hopper Chidlaw A, Schwerk P, Thompson A, Tedin K. Salmonella Co-opts Host Cell Chaperone-mediated Autophagy for Intracellular Growth. J Biol Chem. 2017;292:1847-1864 pubmed publisher
    ..Furthermore, this study provides an explanation as to how Salmonella evades activation of autophagy mechanisms as part of the innate immune response. ..
  50. Pérez L, McLetchie S, Gardiner G, Deffit S, Zhou D, Blum J. LAMP-2C Inhibits MHC Class II Presentation of Cytoplasmic Antigens by Disrupting Chaperone-Mediated Autophagy. J Immunol. 2016;196:2457-65 pubmed publisher
    ..Thus, LAMP-2C serves as a natural inhibitor of CMA that can selectively skew MHCII presentation of cytoplasmic Ags. ..
  51. Jedlitschky G, Tirschmann K, Lubenow L, Nieuwenhuis H, Akkerman J, Greinacher A, et al. The nucleotide transporter MRP4 (ABCC4) is highly expressed in human platelets and present in dense granules, indicating a role in mediator storage. Blood. 2004;104:3603-10 pubmed
    ..The results indicate a function of MRP4 in platelet mediator storage and inhibition of MRP4 may represent a novel mechanism for inhibition of platelet function by some anti-inflammatory drugs. ..
  52. Eskelinen E, Cuervo A, Taylor M, Nishino I, Blum J, Dice J, et al. Unifying nomenclature for the isoforms of the lysosomal membrane protein LAMP-2. Traffic. 2005;6:1058-61 pubmed
    ..To avoid confusion in the literature, we further propose to adopt the use of capital letters for the updated nomenclature of all the isoforms in all three species: LAMP-2A, LAMP-2B, and LAMP-2C. ..
  53. Jennewein L, Ronellenfitsch M, Antonietti P, Ilina E, Jung J, Stadel D, et al. Diagnostic and clinical relevance of the autophago-lysosomal network in human gliomas. Oncotarget. 2016;7:20016-32 pubmed publisher
  54. Couto N, Pedersane D, Rezende L, Dias P, Corbani T, Bentini L, et al. LAMP-2 absence interferes with plasma membrane repair and decreases T. cruzi host cell invasion. PLoS Negl Trop Dis. 2017;11:e0005657 pubmed publisher
    ..The results presented here show the major role of LAMP-2 in caveolin traffic and membrane repair and consequently in T. cruzi invasion. ..
  55. Carlsson S, Lycksell P, Fukuda M. Assignment of O-glycan attachment sites to the hinge-like regions of human lysosomal membrane glycoproteins lamp-1 and lamp-2. Arch Biochem Biophys. 1993;304:65-73 pubmed
    ..These results, taken together, strongly suggest that a hinge region does not display any typical ordered structure. The presence of O-glycans thus likely protects this region from intralumenal lysosomal proteases. ..
  56. Yan M, Zhu W, Zheng X, Li Y, Tang L, Lu B, et al. Effect of glutamate on lysosomal membrane permeabilization in primary cultured cortical neurons. Mol Med Rep. 2016;13:2499-505 pubmed publisher
    ..Overall, these data shed light on the role of ROS-mediated LMP in early glutamate excitotoxicity. ..
  57. Yoshida S, Nakanishi C, Okada H, Mori M, Yokawa J, Yoshimuta T, et al. Characteristics of induced pluripotent stem cells from clinically divergent female monozygotic twins with Danon disease. J Mol Cell Cardiol. 2017;114:234-242 pubmed publisher
  58. Ebner P, Poetsch I, Deszcz L, Hoffmann T, Zuber J, Ikeda F. The IAP family member BRUCE regulates autophagosome-lysosome fusion. Nat Commun. 2018;9:599 pubmed publisher
    ..Thus, BRUCE promotes autolysosome formation independently of its ubiquitin-conjugating activity and is a regulator of both macroautophagy and apoptosis. ..
  59. Yang Z, Funke B, Cripe L, Vick G, Mancini Dinardo D, Peña L, et al. LAMP2 microdeletions in patients with Danon disease. Circ Cardiovasc Genet. 2010;3:129-37 pubmed publisher
    ..The microdeletion mechanism appears to involve 1 Alu-mediated unequal recombination and 2 chromosomal breakage points involving TA-rich repeat sequences. ..
  60. Duncan E, Larivière R, Bradshaw T, Longo F, Sgarioto N, Hayes M, et al. Altered organization of the intermediate filament cytoskeleton and relocalization of proteostasis modulators in cells lacking the ataxia protein sacsin. Hum Mol Genet. 2017;26:3130-3143 pubmed publisher
    ..These data show that loss of sacsin effects the organization of intermediate filaments in multiple cell types, which impacts the cellular distribution of other organelles and influences autophagic activity. ..
  61. Fortunato F, Bürgers H, Bergmann F, Rieger P, Buchler M, Kroemer G, et al. Impaired autolysosome formation correlates with Lamp-2 depletion: role of apoptosis, autophagy, and necrosis in pancreatitis. Gastroenterology. 2009;137:350-60, 360.e1-5 pubmed publisher
    ..The combination of alcohol and endotoxemia attenuated apoptosis response yet enhanced acinar cell necrosis. The depletion of lysosomal proteins plays a critical role in the early onset of acute pancreatitis. ..
  62. Wheeler D, Zoncu R, Root D, Sabatini D, Sawyers C. Identification of an oncogenic RAB protein. Science. 2015;350:211-7 pubmed publisher
  63. Israels S, McMillan E, Robertson C, Singhory S, McNicol A. The lysosomal granule membrane protein, LAMP-2, is also present in platelet dense granule membranes. Thromb Haemost. 1996;75:623-9 pubmed
    ..These data indicate that LAMP-2 is present in the membranes of platelet dense granules in addition to lysosomal granules, and has a similar distribution to CD63. ..
  64. Fields J, Dumaop W, Eleuteri S, Elueteri S, Campos S, Serger E, et al. HIV-1 Tat alters neuronal autophagy by modulating autophagosome fusion to the lysosome: implications for HIV-associated neurocognitive disorders. J Neurosci. 2015;35:1921-38 pubmed publisher
    ..Therapies targeting Tat-mediated autophagy alterations may decrease neurodegeneration in aging patients with HAND. ..
  65. Damaghi M, Tafreshi N, Lloyd M, Sprung R, Estrella V, Wojtkowiak J, et al. Chronic acidosis in the tumour microenvironment selects for overexpression of LAMP2 in the plasma membrane. Nat Commun. 2015;6:8752 pubmed publisher
    ..Our findings suggest a potential adaptive mechanism, wherein cells chronically exposed to an acidic environment translocate lysosomal proteins to their surface, thus protecting the plasmalemma from acid-induced hydrolysis. ..
  66. Roark E, Haldar K. Effects of lysosomal membrane protein depletion on the Salmonella-containing vacuole. PLoS ONE. 2008;3:e3538 pubmed publisher
    ..Together, the data suggests that despite its abundance, LAMP-1 is not essential, but LAMP-2 may be partially important for the Salmonella-containing vacuolar membrane. ..
  67. Rodriguez Ortiz C, Flores J, Valenzuela J, Rodriguez G, Zumkehr J, Tran D, et al. The Myoblast C2C12 Transfected with Mutant Valosin-Containing Protein Exhibits Delayed Stress Granule Resolution on Oxidative Stress. Am J Pathol. 2016;186:1623-34 pubmed publisher
    ..Our findings support that deficiencies in recovery from stressors may result in attenuated tolerance to stress that could trigger muscle degeneration. ..
  68. Maiti K, Sultana Z, Aitken R, Morris J, Park F, Andrew B, et al. Evidence that fetal death is associated with placental aging. Am J Obstet Gynecol. 2017;217:441.e1-441.e14 pubmed publisher
    ..Our data are consistent with a role for aldehyde oxidase 1 and G-protein-coupled estrogen receptor 1 in mediating aging of the placenta that may contribute to stillbirth. The placenta is a tractable model of aging in human tissue. ..
  69. Morita H, Rehm H, Menesses A, McDonough B, Roberts A, Kucherlapati R, et al. Shared genetic causes of cardiac hypertrophy in children and adults. N Engl J Med. 2008;358:1899-908 pubmed publisher
    ..Genetic causes account for about half of presumed sporadic cases and nearly two thirds of familial cases of childhood-onset hypertrophy. Childhood-onset hypertrophy should prompt genetic analyses and family evaluations. ..
  70. Behnke J, Schneppenheim J, Koch Nolte F, Haag F, Saftig P, Schröder B. Signal-peptide-peptidase-like 2a (SPPL2a) is targeted to lysosomes/late endosomes by a tyrosine motif in its C-terminal tail. FEBS Lett. 2011;585:2951-7 pubmed publisher
    ..This motif accounts for the differential localisation of the homologous proteases SPPL2a and SPPL2b and thereby influences the access to substrates and biological function of SPPL2a. ..
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