lamin B

Summary

Gene Symbol: lamin B
Description: lamin B1
Alias: ADLD, LMN, LMN2, LMNB, lamin-B1
Species: human
Products:     lamin B

Top Publications

  1. Rao L, Perez D, White E. Lamin proteolysis facilitates nuclear events during apoptosis. J Cell Biol. 1996;135:1441-55 pubmed
    ..Thus, lamin breakdown by proteolytic degradation facilitates the nuclear events of apoptosis perhaps by facilitating nuclear breakdown. ..
  2. Broers J, Machiels B, Kuijpers H, Smedts F, van den Kieboom R, Raymond Y, et al. A- and B-type lamins are differentially expressed in normal human tissues. Histochem Cell Biol. 1997;107:505-17 pubmed
    ..In contrast to previous studies, which suggested the ubiquitous expression of lamin B1 in mammalian tissues, we show that lamin B1 is not as universally distributed throughout normal human tissues as ..
  3. Tsai M, Wang S, Heidinger J, Shumaker D, Adam S, Goldman R, et al. A mitotic lamin B matrix induced by RanGTP required for spindle assembly. Science. 2006;311:1887-93 pubmed
    ..We report that the intermediate filament protein lamin B, a component of the interphase nuclear lamina, functions in spindle assembly...
  4. Tang C, Maya Mendoza A, Martin C, Zeng K, Chen S, Feret D, et al. The integrity of a lamin-B1-dependent nucleoskeleton is a fundamental determinant of RNA synthesis in human cells. J Cell Sci. 2008;121:1014-24 pubmed publisher
    ..In HeLa cells, we show that reduced expression of lamin B1, but not lamin A/C, severely inhibits RNA synthesis--first by RNA polymerase II and later by RNA polymerase I...
  5. Shimi T, Pfleghaar K, Kojima S, Pack C, Solovei I, Goldman A, et al. The A- and B-type nuclear lamin networks: microdomains involved in chromatin organization and transcription. Genes Dev. 2008;22:3409-21 pubmed publisher
    ..Silencing lamin B1 (LB1) expression dramatically increases the lamina meshwork size and the mobility of nucleoplasmic lamin A (LA)...
  6. Brussino A, Vaula G, Cagnoli C, Mauro A, Pradotto L, Daniele D, et al. A novel family with Lamin B1 duplication associated with adult-onset leucoencephalopathy. J Neurol Neurosurg Psychiatry. 2009;80:237-40 pubmed publisher
    Duplication of the lamin B1 gene (LMNB1) has recently been described in a rare form of autosomal dominant adult-onset leucoencephalopathy...
  7. Ma L, Tsai M, Wang S, Lu B, Chen R, Yates J, et al. Requirement for Nudel and dynein for assembly of the lamin B spindle matrix. Nat Cell Biol. 2009;11:247-56 pubmed publisher
    ..triphosphatase Ran loaded with GTP (RanGTP) can stimulate assembly of the type V intermediate filament protein lamin B into a membranous lamin B spindle matrix, which is required for proper microtubule organization during spindle ..
  8. Brussino A, Vaula G, Cagnoli C, Panza E, Seri M, Di Gregorio E, et al. A family with autosomal dominant leukodystrophy linked to 5q23.2-q23.3 without lamin B1 mutations. Eur J Neurol. 2010;17:541-9 pubmed publisher
    Duplications of lamin B1 (LMNB1) at 5q23 are implicated in adult-onset autosomal dominant leukodystrophy (ADLD) having been described in six families with diverse ethnic background but with a homogeneous phenotype...
  9. Liu G, Barkho B, Ruiz S, Diep D, Qu J, Yang S, et al. Recapitulation of premature ageing with iPSCs from Hutchinson-Gilford progeria syndrome. Nature. 2011;472:221-5 pubmed publisher
    ..Because progerin also accumulates during physiological ageing, our results provide an in vitro iPSC-based model to study the pathogenesis of human premature and physiological vascular ageing...

More Information

Publications169 found, 100 shown here

  1. Shimi T, Butin Israeli V, Adam S, Hamanaka R, Goldman A, Lucas C, et al. The role of nuclear lamin B1 in cell proliferation and senescence. Genes Dev. 2011;25:2579-93 pubmed publisher
    Nuclear lamin B1 (LB1) is a major structural component of the nucleus that appears to be involved in the regulation of many nuclear functions...
  2. Barascu A, Le Chalony C, Pennarun G, Genet D, Imam N, Lopez B, et al. Oxidative stress induces an ATM-independent senescence pathway through p38 MAPK-mediated lamin B1 accumulation. EMBO J. 2012;31:1080-94 pubmed publisher
    ..nuclear shape alterations in A-T cells, as well as accumulation of the key nuclear architecture component lamin B1. Lamin B1 overexpression is sufficient to induce nuclear shape alterations and senescence in wild-type cells, and ..
  3. Freund A, Laberge R, Demaria M, Campisi J. Lamin B1 loss is a senescence-associated biomarker. Mol Biol Cell. 2012;23:2066-75 pubmed publisher
    ..We show here than lamin B1 is lost from primary human and murine cell strains when they are induced to senesce by DNA damage, replicative ..
  4. Columbaro M, Mattioli E, Maraldi N, Ortolani M, Gasparini L, D Apice M, et al. Oct-1 recruitment to the nuclear envelope in adult-onset autosomal dominant leukodystrophy. Biochim Biophys Acta. 2013;1832:411-20 pubmed publisher
    ..b>Lamin B1 levels were dramatically increased in ADLD nuclei, both in skin fibroblasts and skeletal muscle fibres...
  5. Dreesen O, Chojnowski A, Ong P, Zhao T, Common J, Lunny D, et al. Lamin B1 fluctuations have differential effects on cellular proliferation and senescence. J Cell Biol. 2013;200:605-17 pubmed publisher
    ..a premature aging syndrome, whereas LMNB1 duplication causes adult-onset autosomal dominant leukodystrophy (ADLD). LMNB1 is reduced in cells from progeria patients, but the significance of this reduction is unclear...
  6. Meijer I, Simoes Lopes A, Laurent S, Katz T, St Onge J, Verlaan D, et al. A novel duplication confirms the involvement of 5q23.2 in autosomal dominant leukodystrophy. Arch Neurol. 2008;65:1496-501 pubmed publisher
    ..However, additional functional studies of lamin B1 overexpression are necessary to elucidate the involvement of lamin B1 in myelination and in degenerative ..
  7. Padiath Q, Fu Y. Autosomal dominant leukodystrophy caused by lamin B1 duplications a clinical and molecular case study of altered nuclear function and disease. Methods Cell Biol. 2010;98:337-57 pubmed publisher
    ..demyelinating disorder that has recently shown to be caused by duplications of the nuclear lamina gene, lamin B1. This chapter attempts to collate and summarize the current knowledge about the disease and the clinical, ..
  8. Schuster J, Sundblom J, Thuresson A, Hassin Baer S, Klopstock T, Dichgans M, et al. Genomic duplications mediate overexpression of lamin B1 in adult-onset autosomal dominant leukodystrophy (ADLD) with autonomic symptoms. Neurogenetics. 2011;12:65-72 pubmed publisher
    ..ADLD is associated with duplications of the lamin B1 (LMNB1) gene but the mechanism by which the rearrangement conveys the phenotype is not fully defined...
  9. Giorgio E, Rolyan H, Kropp L, Chakka A, Yatsenko S, Di Gregorio E, et al. Analysis of LMNB1 duplications in autosomal dominant leukodystrophy provides insights into duplication mechanisms and allele-specific expression. Hum Mutat. 2013;34:1160-71 pubmed publisher
    ..dominant leukodystrophy (ADLD) is an adult onset demyelinating disorder that is caused by duplications of the lamin B1 (LMNB1) gene...
  10. Butin Israeli V, Adam S, Jain N, Otte G, Neems D, Wiesmüller L, et al. Role of lamin b1 in chromatin instability. Mol Cell Biol. 2015;35:884-98 pubmed publisher
    ..We demonstrate that reducing nuclear lamin B1 expression by short hairpin RNA-mediated silencing in cancer cell lines to approximately 50% of normal levels ..
  11. Kurpińska A, Suraj J, Bonar E, Zakrzewska A, Stojak M, Sternak M, et al. Proteomic characterization of early lung response to breast cancer metastasis in mice. Exp Mol Pathol. 2019;107:129-140 pubmed publisher
    ..It seems that the tissue response is an interplay between pro- and anti-metastatic mechanisms accompanied by inflammation, oxidative stress and dysfunction of the barrier endothelial cells. ..
  12. Moisan E, Girard D. Cell surface expression of intermediate filament proteins vimentin and lamin B1 in human neutrophil spontaneous apoptosis. J Leukoc Biol. 2006;79:489-98 pubmed
    ..Herein, we found that among vinculin, paxillin, gelsolin, vimentin, lamin B1, alpha-tubulin, and beta-tubulin, only the two intermediate filament (INFIL) proteins, vimentin and lamin B1, are ..
  13. Kumar G, Guda R, Husain A, Patra R, Kirandeep -, Kasula M. Synthesis and photophysical properties of pyridyl conjugated triazole appended naphthalenediimide derivatives. Photochem Photobiol Sci. 2019;: pubmed publisher
    ..of three substituted triazole appended NDI-derivatives, 2,7-bis(3,5-di(pyridin-X-yl)-4H-1,2,4-triazol-4-yl)benzo[lmn][3,8]phenanthroline-1,3,6,8(2H,7H)-tetraone (where X = 2, NDI-PyTz-1; 3, NDI-PyTz-2; and 4, NDI-PyTz-3), were ..
  14. Terlizzi R, Calandra Buonaura G, Zanigni S, Barletta G, Capellari S, Guaraldi P, et al. A longitudinal study of a family with adult-onset autosomal dominant leukodystrophy: Clinical, autonomic and neuropsychological findings. Auton Neurosci. 2016;195:20-6 pubmed publisher
    Adult-onset autosomal dominant leukodystrophy (ADLD) is a rare progressive neurological disorder caused by Lamin B1 duplication (LMNB1)...
  15. Verschueren A. Motor neuropathies and lower motor neuron syndromes. Rev Neurol (Paris). 2017;173:320-325 pubmed publisher
    ..be difficult to differentially diagnose from other diseases, particularly from the more frequent ALS in its pure LMN form...
  16. Wydner K, McNeil J, Lin F, Worman H, Lawrence J. Chromosomal assignment of human nuclear envelope protein genes LMNA, LMNB1, and LBR by fluorescence in situ hybridization. Genomics. 1996;32:474-8 pubmed
    ..2-q21.3, with a most probable gene assignment to 1q21.3; lamin B receptor (LBR) was localized to 1q42.1; and lamin B1 (LMNB1) was mapped to the interface of bands 5q23.3-q31.1...
  17. Fernandopulle M, Prestil R, Grunseich C, Wang C, Gan L, Ward M. Transcription Factor-Mediated Differentiation of Human iPSCs into Neurons. Curr Protoc Cell Biol. 2018;79:e51 pubmed publisher
    ..can be inducibly differentiated into either cortical (i3 Neurons) or lower motor neurons (i3 LMN) in a rapid, efficient, and scalable manner (Wang et al., 2017)...
  18. Fakhir F, Lkhider M, Badre W, Alaoui R, Pineau P, Ezzikouri S, et al. The -94Ins/DelATTG polymorphism in NFκB1 promoter modulates chronic hepatitis C and liver disease progression. Infect Genet Evol. 2016;39:141-146 pubmed publisher
    ..with HCV infection including 237 mild chronic hepatitis patients and 106 patients with Advanced Liver Disease (AdLD), 78 individuals who naturally cleared HCV and 138 healthy subjects) were genotyped for the NFκB1 and NFκBIA ..
  19. Butler W, Taube J. Oscillatory synchrony between head direction cells recorded bilaterally in the anterodorsal thalamic nuclei. J Neurophysiol. 2017;117:1847-1852 pubmed publisher
    ..However, anatomical tracing has found that each of the lateral mammillary nuclei (LMN) project bilaterally to both of the ADN, suggesting the LMN may be responsible for the functional connectivity ..
  20. Williams T. Motor neurone disease: diagnostic pitfalls. Clin Med (Lond). 2013;13:97-100 pubmed
    ..Atypical presentations, particularly of focal onset and with pure LMN or UMN signs, present a more difficult diagnostic challenge, although perhaps reassuringly, treatable mimics are ..
  21. Lendoire J, Gil L, Imventarza O. Intrahepatic cholangiocarcinoma surgery: the impact of lymphadenectomy. Chin Clin Oncol. 2018;7:53 pubmed publisher
    ..Pathological lymph node metastases (LMN), found in 15% to 45% of the patients, have been recognized as an extremely poor prognostic risk factor, even if ..
  22. Tanio A, Saito H, Uejima C, Takaya S, Yamamoto M, Tokuyasu N, et al. A prognostic index for colorectal cancer based on preoperative absolute lymphocyte, monocyte, and neutrophil counts. Surg Today. 2019;49:245-253 pubmed publisher
    ..Patients were then given lymphocyte-monocyte-neutrophil (LMN) scores by adding the points of their different subgroups (1 point each for LymphLow, MonoHigh..
  23. Ríos Díaz J, Del Baño Aledo M, Tembl Ferrairó J, Chumillas M, Vázquez Costa J, Martínez Payá J. Quantitative neuromuscular ultrasound analysis as biomarkers in amyotrophic lateral sclerosis. Eur Radiol. 2019;: pubmed publisher
    ..However, the combination of both biomarkers increased their ability to detect LMN impairment, suggesting that both biomarkers could be used in a complementary manner for the diagnosis and ..
  24. Kaspi E, Frankel D, Guinde J, Perrin S, Laroumagne S, Robaglia Schlupp A, et al. Low lamin A expression in lung adenocarcinoma cells from pleural effusions is a pejorative factor associated with high number of metastatic sites and poor Performance status. PLoS ONE. 2017;12:e0183136 pubmed publisher
  25. Dreesen O, Ong P, Chojnowski A, Colman A. The contrasting roles of lamin B1 in cellular aging and human disease. Nucleus. 2013;4:283-90 pubmed publisher
    ..Duplication of the LMNB1 locus, leading to elevated levels of lamin B1, causes adult-onset autosomal dominant leukodystrophy (ADLD), a rare genetic disease that leads to demyelination ..
  26. Joyce P, McGoldrick P, Saccon R, Weber W, Fratta P, West S, et al. A novel SOD1-ALS mutation separates central and peripheral effects of mutant SOD1 toxicity. Hum Mol Genet. 2015;24:1883-97 pubmed publisher
    ..Homozgous Sod1(D83G/D83G) mice develop progressive degeneration of lower (LMN) and upper motor neurons, likely due to the same unknown toxic gain of function as occurs in human fALS cases, but ..
  27. Ostlund C, Bonne G, Schwartz K, Worman H. Properties of lamin A mutants found in Emery-Dreifuss muscular dystrophy, cardiomyopathy and Dunnigan-type partial lipodystrophy. J Cell Sci. 2001;114:4435-45 pubmed
    ..The distributions of endogenous lamin A/C, lamin B1 and lamin B2 were also altered in cells expressing these four mutants and three of them caused a loss of emerin ..
  28. Bartoletti Stella A, Gasparini L, Giacomini C, Corrado P, Terlizzi R, Giorgio E, et al. Messenger RNA processing is altered in autosomal dominant leukodystrophy. Hum Mol Genet. 2015;24:2746-56 pubmed publisher
    ..ADLD is caused by duplication of the lamin B1 gene (LMNB1), which leads to its increased expression...
  29. Rolyan H, Tyurina Y, Hernandez M, Amoscato A, Sparvero L, Nmezi B, et al. Defects of Lipid Synthesis Are Linked to the Age-Dependent Demyelination Caused by Lamin B1 Overexpression. J Neurosci. 2015;35:12002-17 pubmed publisher
    b>Lamin B1 is a component of the nuclear lamina and plays a critical role in maintaining nuclear architecture, regulating gene expression and modulating chromatin positioning...
  30. Zhang D, Beresford P, Greenberg A, Lieberman J. Granzymes A and B directly cleave lamins and disrupt the nuclear lamina during granule-mediated cytolysis. Proc Natl Acad Sci U S A. 2001;98:5746-51 pubmed
    ..Lamins A/C are direct substrates of GzmA, but not GzmB. GzmA and GzmB therefore directly target critical caspase substrates in caspase-resistant cells. ..
  31. Rupniak N, Katofiasc M, Burgard E, Thor K. Colorectal and cardiovascular effects of [Lys5,MeLeu9,Nle10]-NKA(4-10) in anesthetized macaques. Naunyn Schmiedebergs Arch Pharmacol. 2018;391:907-914 pubmed publisher
    The effects of the tachykinin NK2 receptor agonist LMN-NKA ([Lys5,MeLeu9,Nle10]-NKA(4-10)) on colorectal and arterial blood pressure were examined in anesthetized macaques...
  32. Brussino A, D Alfonso S, Cagnoli C, Di Gregorio E, Barberis M, Padovan S, et al. Mutations in the lamin B1 gene are not present in multiple sclerosis. Eur J Neurol. 2009;16:544-6 pubmed publisher
    Whole gene duplication of the lamin B1 gene (LMNB1), encoding for a protein of the nuclear lamina, causes an adult-onset autosomal dominant leukodystrophy (ADLD)...
  33. Marson L, Thor K, Katofiasc M, Burgard E, Rupniak N. Prokinetic effects of neurokinin-2 receptor agonists on the bladder and rectum of rats with acute spinal cord transection. Eur J Pharmacol. 2018;819:261-269 pubmed publisher
    ..or sublingual (SL) administration of [Lys5,MeLeu9,Nle10]-NKA(4-10) (LMN-NKA)...
  34. Ghosh S, Roy S, Liu C, Mohanta S. A nickel(ii)-manganese(ii)-azido layered coordination polymer showing a three-dimensional ferrimagnetic order at 35 K. Dalton Trans. 2018;47:836-844 pubmed publisher
    ..two-dimensional azido-bridged NiIIMnII heterometallic coordination polymer, [{(NiIILMnII)2(μ1,1,3-N3)2}(μ1,3-N3)2
  35. Piva R, Lambertini E, Manferdini C, Capanni C, Penolazzi L, Gabusi E, et al. Slug transcription factor and nuclear Lamin B1 are upregulated in osteoarthritic chondrocytes. Osteoarthritis Cartilage. 2015;23:1226-30 pubmed publisher
    ..Specifically, we investigated the relationship between the nuclear lamina protein Lamin B1 and the negative regulator of chondrogenesis Slug transcription factor in osteoarthritic chondrocytes...
  36. Skvarova Kramarzova K, Osborn M, Webber B, Defeo A, McElroy A, Kim C, et al. CRISPR/Cas9-Mediated Correction of the FANCD1 Gene in Primary Patient Cells. Int J Mol Sci. 2017;18: pubmed publisher
    ..Altogether we show the ability to correct a patient mutation in primary FANCD1 cells in a precise manner. These proof of principle studies support expanded application of gene editing for FA. ..
  37. Rupniak N, Katofiasc M, Walz A, Thor K, Burgard E. [Lys5,MeLeu9,Nle10]-NKA(4-10) Elicits NK2 Receptor-Mediated Micturition and Defecation, and NK1 Receptor-Mediated Emesis and Hypotension, in Conscious Dogs. J Pharmacol Exp Ther. 2018;366:136-144 pubmed publisher
    ..The ability of [Lys5,MeLeu9,Nle10]-neurokinin A(4-10) (LMN-NKA) to elicit micturition and defecation was examined after repeated administration in groups of 2-10 conscious ..
  38. Ito S, Eda H, Ban F, Yanagi K. Epstein-Barr virus nuclear antigen-1 colocalizes with lamin B1 in the nucleoplasm and along the nuclear rim. Arch Virol. 2003;148:1633-42 pubmed
    ..We report here that EBNA-1 coincided with lamin B1 in the nucleoplasm and around the nuclear rim during S-phase by confocal microscopy of cells transfected with ..
  39. Sadaie M, Salama R, Carroll T, Tomimatsu K, Chandra T, Young A, et al. Redistribution of the Lamin B1 genomic binding profile affects rearrangement of heterochromatic domains and SAHF formation during senescence. Genes Dev. 2013;27:1800-8 pubmed publisher
    ..Studying a key component of the nuclear lamina lamin B1 (LMNB1), we report dynamic alterations in its genomic profile and their implications for SAHF formation and gene ..
  40. Ahmad S, Beg Z. Hypolipidemic and antioxidant activities of thymoquinone and limonene in atherogenic suspension fed rats. Food Chem. 2013;138:1116-24 pubmed publisher
    The hypolipidemic and antioxidant actions of thymoquinone (TQ) and limonene (LMN) were investigated by giving 1 ml of 10mg TQ or 200mg LMN suspension, by gavage in two equal doses (morning and evening) of 0...
  41. Robinson A, Partridge D, Malhas A, de Castro S, Gustavsson P, Thompson D, et al. Is LMNB1 a susceptibility gene for neural tube defects in humans?. Birth Defects Res A Clin Mol Teratol. 2013;97:398-402 pubmed publisher
    ..In contrast, coding or loss of function mutations of LMNB1, encoding lamin B1, have not been identified in human disease...
  42. Camps J, Wangsa D, Falke M, Brown M, Case C, Erdos M, et al. Loss of lamin B1 results in prolongation of S phase and decondensation of chromosome territories. FASEB J. 2014;28:3423-34 pubmed publisher
    Nuclear lamin B1 (LMNB1) constitutes one of the major structural proteins in the lamina mesh...
  43. Fitzpatrick J, Anderson R, McDermott K. MicroRNA: Key regulators of oligodendrocyte development and pathobiology. Int J Biochem Cell Biol. 2015;65:134-8 pubmed publisher
    ..emerged which link miRNAs with OL and myelin pathology in various central nervous system (CNS) diseases including multiple sclerosis (MS), ischemic stroke, spinal cord injury, and adult-onset autosomal dominant leukodystrophy (ADLD).
  44. Pomari E, Dalla Valle L, Pertile P, Colombo L, Thornton M. Intracrine sex steroid synthesis and signaling in human epidermal keratinocytes and dermal fibroblasts. FASEB J. 2015;29:508-24 pubmed publisher
    ..genes important in repair and aging [angiopoietin-like 4 (ANGPTL4), chemokine (C-X-C motif) ligand 1 (CXCL1), lamin B1 (LMNB1), and thioredoxin interacting protein (TXNIP)]...
  45. Bao J, Nanding A, Song H, Xu R, Qu G, Xue Y. The overexpression of MDM4: an effective and novel predictor of gastric adenocarcinoma lymph node metastasis. Oncotarget. 2016;7:67212-67222 pubmed publisher
    ..MDM4 expression may result in LMN of GTAC...
  46. Rupniak N, Katofiasc M, Marson L, Thor K. NK2 and NK1 receptor-mediated effects of NKA and analogs on colon, bladder, and arterial pressure in anesthetized dogs. Naunyn Schmiedebergs Arch Pharmacol. 2018;391:299-308 pubmed publisher
    ..Intravenous (IV) administration of NKA, LMN-NKA ([Lys5,MeLeu9,Nle10]-NKA(4-10)), and [β-Ala8]-NKA(..
  47. Lee J, Jung H, Fong L, Young S. Do lamin B1 and lamin B2 have redundant functions?. Nucleus. 2014;5:287-92 pubmed publisher
    ..To explore that issue, Lee and coworkers generated "reciprocal knock-in mice" (knock-in mice that produce lamin B1 from the Lmnb2 locus and knock-in mice that produce lamin B2 from the Lmnb1 locus)...
  48. Wang Z, Zhao J, Dong H, Qiu G, Zhang Q, Hu W. An asymmetric naphthalimide derivative for n-channel organic field-effect transistors. Phys Chem Chem Phys. 2015;17:26519-24 pubmed publisher
    A new naphthalene diimide (NDI) derivative with an asymmetric aromatic backbone of 2-tetradecylbenzo[lmn]benzo[4,5]imidazo[2,1-b][3,8]phenanthroline-1,3,6(2H)-trione (IZ0) was designed and synthesized...
  49. Schmidt L, Lahrz T, Kraft M, Göen T, Fromme H. Monocyclic and bicyclic monoterpenes in air of German daycare centers and human biomonitoring in visiting children, the LUPE 3 study. Environ Int. 2015;83:86-93 pubmed publisher
    ..Three well-known monoterpenoid air pollutants, viz. α-pinene (αPN), Δ(3)-carene (CRN), and R-limonene (LMN), were measured in indoor air in 45 daycare centers...
  50. Mahajani S, Giacomini C, Marinaro F, De Pietri Tonelli D, Contestabile A, Gasparini L. Lamin B1 levels modulate differentiation into neurons during embryonic corticogenesis. Sci Rep. 2017;7:4897 pubmed publisher
    b>Lamin B1, a key component of the nuclear lamina, plays an important role in brain development. Ablation of endogenous Lamin B1 (Lmnb1) in the mouse strongly impairs embryonic brain development and corticogenesis...
  51. Boileau A, Lalem T, Vausort M, Zhang L, Devaux Y. A 3-gene panel improves the prediction of left ventricular dysfunction after acute myocardial infarction. Int J Cardiol. 2018;254:28-35 pubmed publisher
    ..A 3-gene panel can aid to predict LV dysfunction after MI. Further independent validation is required before considering these findings for molecular diagnostic assay development. ..
  52. Chen Y, Li Y, Xue J, Gong A, Yu G, Zhou A, et al. Wnt-induced deubiquitination FoxM1 ensures nucleus β-catenin transactivation. EMBO J. 2016;35:668-84 pubmed publisher
    ..Therefore, Wnt-induced deubiquitination of FoxM1 represents a novel and critical mechanism for controlling canonical Wnt signaling and cell proliferation. ..
  53. Song Y, Zemlyanov D, Chen X, Su Z, Nie H, Lubach J, et al. Acid-base interactions in amorphous solid dispersions of lumefantrine prepared by spray-drying and hot-melt extrusion using X-ray photoelectron spectroscopy. Int J Pharm. 2016;514:456-464 pubmed publisher
    ..drug-excipient interactions in amorphous solid dispersions (ASDs) of the model basic compound lumefantrine (LMN), with five acidic polymers...
  54. Lo Martire V, Alvente S, Bastianini S, Berteotti C, Bombardi C, Calandra Buonaura G, et al. Mice overexpressing lamin B1 in oligodendrocytes recapitulate the age-dependent motor signs, but not the early autonomic cardiovascular dysfunction of autosomal-dominant leukodystrophy (ADLD). Exp Neurol. 2018;301:1-12 pubmed publisher
    Autosomal dominant leukodystrophy (ADLD) is a rare adult-onset demyelinating disease caused by overexpression of lamin B1, a nuclear lamina filament...
  55. Chenji S, Jha S, Lee D, Brown M, Seres P, Mah D, et al. Investigating Default Mode and Sensorimotor Network Connectivity in Amyotrophic Lateral Sclerosis. PLoS ONE. 2016;11:e0157443 pubmed publisher
    ..by degeneration of upper motor neurons (UMN) arising from the motor cortex in the brain and lower motor neurons (LMN) in the brainstem and spinal cord...
  56. Nishida Y, Aida K, Kihara M, Kobayashi T. Antibody-validated proteins in inflamed islets of fulminant type 1 diabetes profiled by laser-capture microdissection followed by mass spectrometry. PLoS ONE. 2014;9:e107664 pubmed publisher
    ..Several target proteins for future type 1 diabetes interventions were identified. ..
  57. Zhong D, Liao L, Deng J, Chen Q, Lian P, Luo X. A rare (3,4,5)-connected metal-organic framework featuring an unprecedented 1D + 2D → 3D self-interpenetrated array and an O-atom lined pore surface: structure and controlled drug release. Chem Commun (Camb). 2014;50:15807-10 pubmed publisher
    ..with an O-atom lined pore surface has been constructed from Zn(II) and H4L (H4L = 5,5'-(1,3,6,8-tetraoxobenzo[lmn][3,8]phenanthroline-2,7(1H,3H,6H,8H)diyl)-diisophthalic acid), which features an unprecedented 1D + 2D → 3D ..
  58. Sanfilippo C, Longo A, Lazzara F, Cambria D, Distefano G, Palumbo M, et al. CHI3L1 and CHI3L2 overexpression in motor cortex and spinal cord of sALS patients. Mol Cell Neurosci. 2017;85:162-169 pubmed publisher
    ..rapidly progressive neurodegenerative disease characterized by the degeneration and death of upper (UMN) and lower (LMN) motor neurons...
  59. Fernández Fernández L, Esteban G, Giralt M, Valente T, Bolea I, Solé M, et al. Catecholaminergic and cholinergic systems of mouse brain are modulated by LMN diet, rich in theobromine, polyphenols and polyunsaturated fatty acids. Food Funct. 2015;6:1251-60 pubmed publisher
    The possible modulatory effect of the functional LMN diet, rich in theobromine, polyphenols and polyunsaturated fatty acids, on the catecholaminergic and cholinergic neurotransmission, affecting cognition decline during aging has been ..
  60. Cerami C, Marcone A, Crespi C, Iannaccone S, Marangoni C, Dodich A, et al. Motor neuron dysfunctions in the frontotemporal lobar degeneration spectrum: a clinical and neurophysiological study. J Neurol Sci. 2015;351:72-7 pubmed publisher
    ..Clinical and neurophysiological evaluations (i.e. needle electromyography) assessed lower (LMN) and upper (UMN) motor neuron function at the baseline in 70 probable FTLD patients (i.e...
  61. Giacomini C, Mahajani S, Ruffilli R, Marotta R, Gasparini L. Lamin B1 protein is required for dendrite development in primary mouse cortical neurons. Mol Biol Cell. 2016;27:35-47 pubmed publisher
    b>Lamin B1, a key component of the nuclear lamina, plays an important role in brain development and function...
  62. Kim G, Won Y, Ko M, Park S, Seo J. Ultrasonic measurement of rectal diameter and area in neurogenic bowel with spinal cord injury. J Spinal Cord Med. 2016;39:301-6 pubmed publisher
    ..patients with upper motor neuron neurogenic bowel (UMNB) and 16 patients with lower motor neuron neurogenic bowel (LMNB)) participated in this study...
  63. de Carvalho M, Swash M. Lower motor neuron dysfunction in ALS. Clin Neurophysiol. 2016;127:2670-81 pubmed publisher
    In the motor system there is a complex interplay between cortical structures and spinal cord lower motor neurons (LMN). In this system both inhibitory and excitatory neurons have relevant roles...
  64. Foisner R, Gerace L. Integral membrane proteins of the nuclear envelope interact with lamins and chromosomes, and binding is modulated by mitotic phosphorylation. Cell. 1993;73:1267-79 pubmed
    ..Using in vitro assays, we show that LAPs 1A and 1B specifically bind to both lamins A and C and lamin B1, while LAP 2 associates only with lamin B1. LAP 2 also binds to mitotic chromosomes...
  65. Zastrow M, Flaherty D, Benian G, Wilson K. Nuclear titin interacts with A- and B-type lamins in vitro and in vivo. J Cell Sci. 2006;119:239-49 pubmed
    ..overexpressed a lamin-binding fragment of titin, nuclei became grossly misshapen and herniated at sites lacking lamin B. We conclude that the C-terminus of nuclear titin binds lamins in vivo and might contribute to nuclear ..
  66. Muller W, Okamoto T, Reuter P, Ugarkovic D, Schroder H. Functional characterization of Tat protein from human immunodeficiency virus. Evidence that Tat links viral RNAs to nuclear matrix. J Biol Chem. 1990;265:3803-8 pubmed
    ..Present studies indicate that Tat may function as a linker by binding of nascent HIV RNAs to the nuclear matrix. ..
  67. Tunnah D, Sewry C, Vaux D, Schirmer E, Morris G. The apparent absence of lamin B1 and emerin in many tissue nuclei is due to epitope masking. J Mol Histol. 2005;36:337-44 pubmed
    ..studies have concluded that the nuclear membrane protein, emerin, is absent from many cell types and that lamin B1 is absent from adult heart and skeletal muscle...
  68. Dupuis L, Echaniz Laguna A. Skeletal muscle in motor neuron diseases: therapeutic target and delivery route for potential treatments. Curr Drug Targets. 2010;11:1250-61 pubmed
    Lower motor neuron (LMN) degeneration occurs in several diseases that affect patients from neonates to elderly and can either be genetically transmitted or occur sporadically...
  69. Chung S, Armasu S, Biernacka J, Anderson K, Lesnick T, Rider D, et al. Genomic determinants of motor and cognitive outcomes in Parkinson's disease. Parkinsonism Relat Disord. 2012;18:881-6 pubmed publisher
    ..This study suggests that common variants in several genes may be associated with motor and cognitive outcomes in PD, with biological plausibility. ..
  70. Adam S, Butin Israeli V, Cleland M, Shimi T, Goldman R. Disruption of lamin B1 and lamin B2 processing and localization by farnesyltransferase inhibitors. Nucleus. 2013;4:142-50 pubmed publisher
    Lamin A and the B-type lamins, lamin B1 and lamin B2, are translated as pre-proteins that are modified at a carboxyl terminal CAAX motif by farnesylation, proteolysis and carboxymethylation...
  71. Menon P, Kiernan M, Vucic S. Cortical hyperexcitability precedes lower motor neuron dysfunction in ALS. Clin Neurophysiol. 2015;126:803-9 pubmed publisher
    To determine whether cortical hyperexcitability preceded the development of lower motor neuron (LMN) dysfunction in sporadic amyotrophic lateral sclerosis (ALS)...
  72. Küsters Vandevelde H, van Engen van Grunsven I, Coupland S, Lake S, Rijntjes J, Pfundt R, et al. Mutations in g protein encoding genes and chromosomal alterations in primary leptomeningeal melanocytic neoplasms. Pathol Oncol Res. 2015;21:439-47 pubmed publisher
    ..This finding may help in the differential diagnosis between a primary LMN and a metastasis from a cutaneous melanoma to the central nervous system...
  73. Yoder R, Peck J, Taube J. Visual landmark information gains control of the head direction signal at the lateral mammillary nuclei. J Neurosci. 2015;35:1354-67 pubmed publisher
    ..direction (HD) cells located in an ascending circuit that includes projections from the lateral mammillary nuclei (LMN) to the anterodorsal thalamus (ADN) to the postsubiculum (PoS)...
  74. Minchenko O, Tsymbal D, Minchenko D, Prylutska S, Hnatiuk O, Prylutskyy Y, et al. Single-walled carbon nanotubes affect the expression of genes associated with immune response in normal human astrocytes. Toxicol In Vitro. 2018;52:122-130 pubmed publisher
    ..At the same time, the expression of HLA-F (major histocompatibility complex, class I, F), LMNB1 (lamin B1), and HTRA1 (high temperature requirement A1) genes as well as the level of miR-190b and miR-7 was up-regulated ..
  75. Louvet E, Yoshida A, Kumeta M, Takeyasu K. Probing the stiffness of isolated nucleoli by atomic force microscopy. Histochem Cell Biol. 2014;141:365-81 pubmed publisher
    ..This led us to propose a model where the nucleolus has steady-state stiffness dependent on ribosome biogenesis activity and requires LaminB1 for its flexibility. ..
  76. Dos Santos M, Grond Ginsbach C, Aksay S, Chen B, Tchatchou S, Wolf N, et al. Adult-onset autosomal dominant leukodystrophy due to LMNB1 gene duplication. J Neurol. 2012;259:579-81 pubmed publisher
  77. Corlobé A, Taithe F, Clavelou P, Pierre E, Carra Dallière C, Ayrignac X, et al. A novel autosomal dominant leukodystrophy with specific MRI pattern. J Neurol. 2015;262:988-91 pubmed publisher
  78. Costa J, de Carvalho M. Emerging molecular biomarker targets for amyotrophic lateral sclerosis. Clin Chim Acta. 2016;455:7-14 pubmed publisher
    ..lateral sclerosis is a rapidly progressive neurodegenerative disease that affects upper (UMN) and lower motor (LMN) neurons...
  79. Trivedi P, Kumar L, Emmanuel A. Altered Colorectal Compliance and Anorectal Physiology in Upper and Lower Motor Neurone Spinal Injury May Explain Bowel Symptom Pattern. Am J Gastroenterol. 2016;111:552-60 pubmed publisher
    Supraconal spinal cord injury (SCI) and lower motor neurone spinal cord injury (LMN-SCI) cause bowel dysfunction; colorectal compliance may further define its pathophysiology...
  80. Giarratana F, Muscolino D, Beninati C, Ziino G, Giuffrida A, Panebianco A. Activity of R(+) limonene on the maximum growth rate of fish spoilage organisms and related effects on shelf-life prolongation of fresh gilthead sea bream fillets. Int J Food Microbiol. 2016;237:109-113 pubmed publisher
    R(+)limonene (LMN) is the major aromatic compound in essential oils obtained from oranges, grapefruits, and lemons...
  81. de Carvalho M, Pinto S, Swash M. Does the motor cortex influence denervation in ALS? EMG studies of muscles with both contralateral and bilateral corticospinal innervation. Clin Neurophysiol. 2011;122:629-635 pubmed publisher
    ..Our findings are in accord with the concept that LMN degeneration in ALS is related to local factors in the spinal cord...
  82. Gungor B, Adıgüzel E, Gursel I, Yilmaz B, Gursel M. Intestinal Microbiota in Patients with Spinal Cord Injury. PLoS ONE. 2016;11:e0145878 pubmed publisher
    ..We tested our hypothesis on 30 SCI patients (15 upper motor neuron [UMN] bowel syndrome, 15 lower motor neuron [LMN] bowel syndrome) and 10 healthy controls using the 16S rRNA sequencing...
  83. Jin J, Hu F, Zhang Q, Jia R, Dang J. Hyperintensity of the corticospinal tract on FLAIR: A simple and sensitive objective upper motor neuron degeneration marker in clinically verified amyotrophic lateral sclerosis. J Neurol Sci. 2016;367:177-83 pubmed publisher
    ..However, it is difficult to detect in the early stages, and particularly with predominantly lower motor neuron (LMN) dysfunction. Thus, objective and sensitive UMN degeneration markers are needed for an accurate and early diagnosis...
  84. Lukasova E, Kovarˇík A, Bacˇíková A, Falk M, Kozubek S. Loss of lamin B receptor is necessary to induce cellular senescence. Biochem J. 2017;474:281-300 pubmed publisher
    ..Recent studies appear to imply an association of lamin B1 (LB1) reduction with chromatin rearrangement in human fibroblasts promoted to senescence, while the mechanisms ..
  85. Hashimoto K, Majumdar R, Tsuji Y. Nuclear lamins and progerin are dispensable for antioxidant Nrf2 response to arsenic and cadmium. Cell Signal. 2017;33:69-78 pubmed publisher
    ..These results suggest that the nuclear lamins and progerin have marginal roles in the activation of the antioxidant Nrf2 response to arsenic and cadmium. ..
  86. Cox L, Ferraiuolo L, Goodall E, Heath P, Higginbottom A, Mortiboys H, et al. Mutations in CHMP2B in lower motor neuron predominant amyotrophic lateral sclerosis (ALS). PLoS ONE. 2010;5:e9872 pubmed publisher
    ..However, absolute confirmation of pathogenicity requires further evidence, including documentation of familial transmission in ALS pedigrees which might be most fruitfully explored in cases with a LMN predominant phenotype.
  87. Pabbidi M, Ji X, Maxwell J, Mignery G, Samarel A, Lipsius S. Inhibition of cAMP-Dependent PKA Activates ?2-Adrenergic Receptor Stimulation of Cytosolic Phospholipase A2 via Raf-1/MEK/ERK and IP3-Dependent Ca2+ Signaling in Atrial Myocytes. PLoS ONE. 2016;11:e0168505 pubmed publisher
    We previously reported in atrial myocytes that inhibition of cAMP-dependent protein kinase (PKA) by laminin (LMN)-integrin signaling activates ?2-adrenergic receptor (?2-AR) stimulation of cytosolic phospholipase A2 (cPLA2)...
  88. Muller W, Wenger R, Reuter P, Renneisen K, Schroder H. Association of Tat protein and viral mRNA with nuclear matrix from HIV-1-infected H9 cells. Biochim Biophys Acta. 1989;1008:208-12 pubmed
    ..This could be prevented by coincubation with Zn2+ or Cu2+ (but not Mg2+), which stabilize the mRNA containing nuclear matrix structure. ..
  89. Lin F, Worman H. Structural organization of the human gene (LMNB1) encoding nuclear lamin B1. Genomics. 1995;27:230-6 pubmed
    We have determined the structural organization of the human gene (LMNB1) that encodes nuclear lamin B1, an intermediate filament protein of the nuclear envelope...
  90. Ye Q, Worman H. Protein-protein interactions between human nuclear lamins expressed in yeast. Exp Cell Res. 1995;219:292-8 pubmed
    ..Lamin A, prelamin A, lamin B1, and lamin C were able to form homodimers as well as heterodimers...
  91. Maison C, Pyrpasopoulou A, Theodoropoulos P, Georgatos S. The inner nuclear membrane protein LAP1 forms a native complex with B-type lamins and partitions with spindle-associated mitotic vesicles. EMBO J. 1997;16:4839-50 pubmed
    ..The LAP1-lamin B complex is distinct from analogous complexes formed by the 'lamina-associated polypeptide-2' (LAP2), another ..