LAMC2

Summary

Gene Symbol: LAMC2
Description: laminin subunit gamma 2
Alias: B2T, BM600, CSF, EBR2, EBR2A, LAMB2T, LAMNB2, laminin subunit gamma-2, BM600-100kDa, CSF 140 kDa subunit, cell-scattering factor 140 kDa subunit, epiligrin subunit gamma, kalinin subunit gamma, ladsin 140 kDa subunit, laminin B2t chain, laminin, gamma 2, large adhesive scatter factor 140 kDa subunit, nicein subunit gamma
Species: human
Products:     LAMC2

Top Publications

  1. Aberdam D, Galliano M, Vailly J, Pulkkinen L, Bonifas J, Christiano A, et al. Herlitz's junctional epidermolysis bullosa is linked to mutations in the gene (LAMC2) for the gamma 2 subunit of nicein/kalinin (LAMININ-5). Nat Genet. 1994;6:299-304 pubmed
    We have linked Herlitz's junctional epidermolysis bullosa (H-JEB) to the gene (LAMC2) encoding the gamma 2 subunit of nicein/kalinin, an isolaminin (laminin-5) expressed by basal keratinocytes...
  2. Miyazaki K, Kikkawa Y, Nakamura A, Yasumitsu H, Umeda M. A large cell-adhesive scatter factor secreted by human gastric carcinoma cells. Proc Natl Acad Sci U S A. 1993;90:11767-71 pubmed
    ..The 140-kDa peptide contains an amino acid sequence homologous to that of the laminin B2t chain. The native protein has an apparent molecular mass of > 1000 kDa and a pI of 5.0...
  3. Hirosaki T, Mizushima H, Tsubota Y, Moriyama K, Miyazaki K. Structural requirement of carboxyl-terminal globular domains of laminin alpha 3 chain for promotion of rapid cell adhesion and migration by laminin-5. J Biol Chem. 2000;275:22495-502 pubmed
    ..These findings demonstrate that the G3 domain, but not the G4 and G5 domains, of the alpha3 chain is essential for the potent promotion of cell adhesion and motility by laminin-5. ..
  4. Patel V, Aldridge K, Ensley J, Odell E, Boyd A, Jones J, et al. Laminin-gamma2 overexpression in head-and-neck squamous cell carcinoma. Int J Cancer. 2002;99:583-8 pubmed
    ..The data indicate that laminin-gamma2 is frequently overexpressed in HNSCCs and derivative cell lines and that its overexpression is likely to be useful as a marker of head-and-neck squamous malignancy. ..
  5. Lu W, Miyazaki K, Mizushima H, Nemoto N. Immunohistochemical distribution of laminin-5 gamma2 chain and its developmental change in human embryonic and foetal tissues. Histochem J. 2001;33:629-37 pubmed
    ..These results suggest a common role of laminin-5 and some specific roles of its gamma2 chain in the morphogenesis of human tissues. ..
  6. Olsen J, Kirkeby L, Brorsson M, Dabelsteen S, Troelsen J, Bordoy R, et al. Converging signals synergistically activate the LAMC2 promoter and lead to accumulation of the laminin gamma 2 chain in human colon carcinoma cells. Biochem J. 2003;371:211-21 pubmed
    ..The purpose of the present work was to investigate whether TGF-beta 1 and HGF, known to stimulate the LAMC2 gene encoding the laminin gamma 2 chain, might synergize to activate the LAMC2 promoter, and to identify the ..
  7. Burgeson R, Chiquet M, Deutzmann R, Ekblom P, Engel J, Kleinman H, et al. A new nomenclature for the laminins. Matrix Biol. 1994;14:209-11 pubmed
    ..For example, the first laminin identified from the Engelbreth-Holm-Swarm tumor is laminin-1 with the chain composition alpha 1 beta 1 gamma 1. The genes for these chains are LAMA1, LAMB1 and LAMC1, respectively. ..
  8. Mizushima H, Miyagi Y, Kikkawa Y, Yamanaka N, Yasumitsu H, Misugi K, et al. Differential expression of laminin-5/ladsin subunits in human tissues and cancer cell lines and their induction by tumor promoter and growth factors. J Biochem. 1996;120:1196-202 pubmed
    We previously reported a new laminin variant containing laminin gamma 2 (or B2t) chain, ladsin, which exerted prominent cell-scattering, cell-adhesion, and cell-migration activities...
  9. Mizushima H, Koshikawa N, Moriyama K, Takamura H, Nagashima Y, Hirahara F, et al. Wide distribution of laminin-5 gamma 2 chain in basement membranes of various human tissues. Horm Res. 1998;50 Suppl 2:7-14 pubmed
    ..Moreover, deposition of laminin gamma 2 chain around small arteries and veins was observed in the thymus and spleen. This lymphatic organ-specific expression of vascular LN5 might provide a novel function of LN5 in immune responses. ..

More Information

Publications128 found, 100 shown here

  1. Hopkinson S, Jones J. The N terminus of the transmembrane protein BP180 interacts with the N-terminal domain of BP230, thereby mediating keratin cytoskeleton anchorage to the cell surface at the site of the hemidesmosome. Mol Biol Cell. 2000;11:277-86 pubmed
    ..These data provide new insight into those interactions of the molecules of the hemidesmosome that are necessary for its function in integrating epithelial and connective tissue types. ..
  2. Sasaki T, Göhring W, Mann K, Brakebusch C, Yamada Y, Fassler R, et al. Short arm region of laminin-5 gamma2 chain: structure, mechanism of processing and binding to heparin and proteins. J Mol Biol. 2001;314:751-63 pubmed
    ..Immunological studies showed a similar partial processing in cell culture and tissues and the persistence of the released fragment in tissues. This indicated that both N-terminal regions of the gamma2 chain may have a function in vivo. ..
  3. Nakano A, Chao S, Pulkkinen L, Murrell D, Bruckner Tuderman L, Pfendner E, et al. Laminin 5 mutations in junctional epidermolysis bullosa: molecular basis of Herlitz vs. non-Herlitz phenotypes. Hum Genet. 2002;110:41-51 pubmed
    ..27 families, 15 with Herlitz and 12 with non-Herlitz JEB, for mutations in the candidate genes, LAMA3, LAMB3, and LAMC2, encoding the subunit polypeptides of laminin 5...
  4. Meng X, Klement J, Leperi D, Birk D, Sasaki T, Timpl R, et al. Targeted inactivation of murine laminin gamma2-chain gene recapitulates human junctional epidermolysis bullosa. J Invest Dermatol. 2003;121:720-31 pubmed
    ..mutations in six distinct genes expressed in the cutaneous basement membrane zone; these include LAMA3, LAMB3, and LAMC2, which encode laminin 5 subunit polypeptides, the alpha3-, beta3-, and gamma2-chains, respectively...
  5. Gasparoni A, Della Casa M, Milillo L, Lorenzini G, Rubini C, Urso R, et al. Prognostic value of differential expression of Laminin-5 gamma2 in oral squamous cell carcinomas: correlation with survival. Oncol Rep. 2007;18:793-800 pubmed
    ..The number of gamma2-positive cells also correlated with the histopathological pattern of invasion. Our results show that gamma2 may be a reliable prognostic tool for oral squamous cell carcinomas. ..
  6. Kariya Y, Kawamura C, Tabei T, Gu J. Bisecting GlcNAc residues on laminin-332 down-regulate galectin-3-dependent keratinocyte motility. J Biol Chem. 2010;285:3330-40 pubmed publisher
    ..The findings presented herein shed light on the importance of N-glycosylation-mediated supramolecular complex formation on the cell surface. ..
  7. van den Bergh F, Eliason S, Giudice G. Type XVII collagen (BP180) can function as a cell-matrix adhesion molecule via binding to laminin 332. Matrix Biol. 2011;30:100-8 pubmed publisher
    ..These findings provide strong support for the hypothesis that cell surface COL17 can interact with laminin 332 and, together, participate in the adherence of a cell to the extracellular matrix. ..
  8. Jarius S, Kleiter I, Ruprecht K, Asgari N, Pitarokoili K, Borisow N, et al. MOG-IgG in NMO and related disorders: a multicenter study of 50 patients. Part 3: Brainstem involvement - frequency, presentation and outcome. J Neuroinflammation. 2016;13:281 pubmed
    ..Cerebrospinal fluid pleocytosis was found in 11/14 cases, with neutrophils in 7/11 (3-34 % of all CSF white blood cells), and oligoclonal bands in 4/14...
  9. Góralska K, Blaszkowska J, Dzikowiec M. Neuroinfections caused by fungi. Infection. 2018;46:443-459 pubmed publisher
    ..others, deoxycholate-AmBd and liposomal L-AmB) have relatively limited distribution in the cerebrospinal fluid (CSF); however, their detectable therapeutic concentrations in the CNS makes them recommended drugs for the treatment of ..
  10. Mazzio E, Bauer D, Mendonça P, Taka E, Soliman K. Natural product HTP screening for attenuation of cytokine-induced neutrophil chemo attractants (CINCs) and NO2- in LPS/IFNγ activated glioma cells. J Neuroimmunol. 2017;302:10-19 pubmed publisher
    ..The data show no changes to the following, IL-13, TNF-a, fracktaline, leptin, LIX, GM-CSF, ICAM1, L-Selectin, activin A, agrin, IL-1α, MIP-3a, B72/CD86, NGF, IL-1b, MMP-8, IL-1 R6, PDGF-AA, IL-2, IL-4, ..
  11. Kiang J, Smith J, Anderson M, Elliott T, Gupta P, Balakathiresan N, et al. Hemorrhage enhances cytokine, complement component 3, and caspase-3, and regulates microRNAs associated with intestinal damage after whole-body gamma-irradiation in combined injury. PLoS ONE. 2017;12:e0184393 pubmed publisher
    ..In serum, RI caused an increase of IL-1, IL-2, IL-3, IL-5, IL-6, IL-12, IL-13, IL-15, IL-17A, IL-18, G-CSF, CM-CSF, eotaxin, IFN-?, MCP-1, MIP, RANTES, and TNF-?, which were all increased by hemorrhage alone, except IL-9, ..
  12. Jarius S, Ruprecht K, Kleiter I, Borisow N, Asgari N, Pitarokoili K, et al. MOG-IgG in NMO and related disorders: a multicenter study of 50 patients. Part 2: Epidemiology, clinical presentation, radiological and laboratory features, treatment responses, and long-term outcome. J Neuroinflammation. 2016;13:280 pubmed
    ..To describe the epidemiological, clinical, radiological, cerebrospinal fluid (CSF), and electrophysiological features of a large cohort of MOG-IgG-positive patients with optic neuritis (ON) and/or ..
  13. Laval K, Vernejoul J, Van Cleemput J, Koyuncu O, Enquist L. Virulent Pseudorabies Virus Infection Induces a Specific and Lethal Systemic Inflammatory Response in Mice. J Virol. 2018;92: pubmed publisher
    ..plasma levels of proinflammatory cytokines (interleukin-6 [IL-6] and granulocyte colony-stimulating factor [G-CSF]) and chemokines (Gro-1 and monocyte chemoattractant protein 1)...
  14. Ural S, Özer B, Gelal F, Dirim Erdoğan D, Sezak N, Balık R, et al. [Transverse myelitis associated with toxocariasis and the importance of locally produced antibodies for diagnosis]. Mikrobiyol Bul. 2016;50:478-83 pubmed
    ..Examination of CSF showed 20 cells/mm3 (mononuclear cells), 45 mg/dl protein and normal levels of glucose and chlorine...
  15. Markel T, Crafts T, Jensen A, Hunsberger E, Yoder M. Human mesenchymal stromal cells decrease mortality after intestinal ischemia and reperfusion injury. J Surg Res. 2015;199:56-66 pubmed publisher
    ..by gamma interferon (MIG), monocyte chemoattractant protein 1, IL-6, granulocyte colony-stimulating factor (G-CSF), and interferon gamma-induced protein 10 (IP-10) from ischemia were appreciated...
  16. Kameyama H, Udagawa O, Hoshi T, Toukairin Y, Arai T, Nogami M. The mRNA expressions and immunohistochemistry of factors involved in angiogenesis and lymphangiogenesis in the early stage of rat skin incision wounds. Leg Med (Tokyo). 2015;17:255-60 pubmed publisher
    ..angiopoietin (ANGPT) 1 and 2, cadherin 5 (CDH5), granulocyte-macrophage colony stimulating factor (CSF2/GM-CSF), granulocyte colony stimulating factor (CSF3/G-CSF), chemokine (C-X-C motif) ligand 2 (CXCL2), chemokine (C-X-C ..
  17. Akbari B, Farajnia S, Ahdi Khosroshahi S, Safari F, Yousefi M, Dariushnejad H, et al. Immunotoxins in cancer therapy: Review and update. Int Rev Immunol. 2017;36:207-219 pubmed publisher
    ..form of gelonin; NKC: natural killer cells; HTR: human transferrin receptor; EGF: epidermal growth factor; GM-CSF: granulocyte-macrophage colony-stimulating factor; DAB389: truncated Diphtheria toxin; B-CCL: B-cell chronic ..
  18. Kurose T, Hashimoto M, Ozawa J, Kawamata S. Analysis of Gene Expression in Experimental Pressure Ulcers in the Rat with Special Reference to Inflammatory Cytokines. PLoS ONE. 2015;10:e0132622 pubmed publisher
    ..Real-Time PCR showed the up-regulation of granulocyte-macrophage colony stimulating factor (GM-CSF), interferon γ (IFN-γ), interleukin 1β (IL-1β), interleukin 1 receptor antagonist gene (IL1Ra), ..
  19. Seo B, Ryu H, Park Y, Huh J, Baek Y. Dual effect of WIN-34B on osteogenesis and osteoclastogenesis in cytokine-induced mesenchymal stem cells and bone marrow cells. J Ethnopharmacol. 2016;193:227-236 pubmed publisher
    ..and treated with receptor activator of nuclear factor-?B ligand (RANKL) and macrophage colony stimulating factor (m-CSF) to induce osteoclastogenesis...
  20. Letsa T, Noora C, Kuma G, Asiedu E, Kye Duodu G, Afari E, et al. Pneumococcal meningitis outbreak and associated factors in six districts of Brong Ahafo region, Ghana, 2016. BMC Public Health. 2018;18:781 pubmed publisher
    ..We collected CSF samples and performed serological testing using Pastorex-Meningitis-Kit and culture for bacterial isolation...
  21. Sibon I, de Toffol B, Azulay J, Sellal F, Thomas Antérion C, Léger J, et al. [American Academy of Neurology, Washington, 18-25 April 2015]. Rev Neurol (Paris). 2015;171:581-601 pubmed publisher
    ..The respective value of biomarkers (amyloid imaging versus CSF biomarkers) for in vivo diagnosis of Alzheimer's disease (AD) has been detailed...
  22. Xiao H, Xiong L, Song X, Jin P, Chen L, Chen X, et al. Angelica sinensis Polysaccharides Ameliorate Stress-Induced Premature Senescence of Hematopoietic Cell via Protecting Bone Marrow Stromal Cells from Oxidative Injuries Caused by 5-Fluorouracil. Int J Mol Sci. 2017;18: pubmed publisher
    ..stem cell factor (SCF), stromal cell-derived factor (SDF), and granulocyte-macrophage colony-stimulating factor (GM-CSF), however, elevated inflammatory chemokines such as RANTES...
  23. Maffeis L, Dilena R, Guez S, Menni F, Bana C, Osnaghi S, et al. Pseudotumour cerebri associated with mycoplasma pneumoniae infection and treatment with levofloxacin: a case report. BMC Pediatr. 2019;19:4 pubmed publisher
    ..to know that some antibiotics may have the potential to precipitate PTCS in patients who already have an increased CSF pressure due to a transitory imbalanced CSF circulation caused by infections such as Mycoplasma pneumoniae, with ..
  24. Mohammadi A, Rashidi E, Amooeian V. Brain, blood, cerebrospinal fluid, and serum biomarkers in schizophrenia. Psychiatry Res. 2018;265:25-38 pubmed publisher
    ..The main goal of the current review is to provide a comprehensive view of the brain, blood, cerebrospinal fluid (CSF), and serum biomarkers of Scz disease...
  25. Gariup M, González A, Lázaro L, Torres F, Serra Pagès C, Morer A. IL-8 and the innate immunity as biomarkers in acute child and adolescent psychopathology. Psychoneuroendocrinology. 2015;62:233-42 pubmed publisher
    ..interleukin (IL)-1β, IL-2, IL-4, IL-5, IL-6, IL-8, IL_10, granulocyte-macrophage colony-stimulating factor (GM-CSF), interferon (IFN)-γ, tumor necrosis factor (TNF)-α, IFN-γ-induced protein-10 (IP-10), monocyte ..
  26. Ertilav M, Ozkul A, Zeytinoğlu A, Sen S, Sipahi S, Töz H, et al. [Meningoencephalitis caused by West Nile virus in a renal transplant recipient]. Mikrobiyol Bul. 2014;48:674-82 pubmed
    ..as meningoencephalitis with the results of cranial magnetic resonance imaging (MR) and cerebrospinal fluid (CSF) biochemistry. Bacterial and fungal cultures of blood and CSF yielded negative results...
  27. Kiang J, Zhai M, Bolduc D, Smith J, Anderson M, Ho C, et al. Combined Therapy of Pegylated G-CSF and Alxn4100TPO Improves Survival and Mitigates Acute Radiation Syndrome after Whole-Body Ionizing Irradiation Alone and Followed by Wound Trauma. Radiat Res. 2017;188:476-490 pubmed publisher
    ..We observed, that animals treated with both pegylated G-CSF (a cytokine for neutrophil maturation and mobilization) and Alxn4100TPO (a thrombopoietin receptor agonist) at 4 h ..
  28. Vawter Lee M, Hallinan B, Burrow T, Spaeth C, Arthur T. A Novel Catastrophic Presentation of X-Linked Adrenoleukodystrophy. JIMD Rep. 2015;24:97-102 pubmed publisher
    ..Nine months after presentation, CSF (cerebrospinal fluid) protein and MRS lactate were persistently elevated, concerning for a neurodegenerative ..
  29. Moussa C, Hebron M, Huang X, Ahn J, Rissman R, Aisen P, et al. Resveratrol regulates neuro-inflammation and induces adaptive immunity in Alzheimer's disease. J Neuroinflammation. 2017;14:1 pubmed publisher
    ..52 weeks with the SIRT1 activator resveratrol (up to 1 g by mouth twice daily) attenuates progressive declines in CSF Aβ40 levels and activities of daily living (ADL) scores...
  30. Yılmaz M, Dagli M, Uku O, Bilen M, Korkmaz H, Erdem K, et al. Focusing on a complete blood cell parameter: mean platelet volume levels may be a predictor of coronary slow flow. Vasc Health Risk Manag. 2017;13:255-261 pubmed publisher
    ..In the present study, MPV in patients with coronary slow flow (CSF) and in cases with normal coronary anatomy (NCA) was investigated and compared with the aim of identifying the ..
  31. Schupp J, Tchaptchet S, Lützen N, Engelhard P, Müller Quernheim J, Freudenberg M, et al. Immune response to Propionibacterium acnes in patients with sarcoidosis--in vivo and in vitro. BMC Pulm Med. 2015;15:75 pubmed publisher
    ..In a subcohort of sarcoid patients and controls, TNF-α and GM-CSF production of BAL cells stimulated with heat-killed P. acnes were measured...
  32. Gorskaya Y, Danilova T, Grabko V, Nesterenko V. Successive Administration of Streptococcus Type 5 Group A Antigens and S. typhimurium Antigenic Complex Corrects Elevation of Serum Cytokine Concentration and Number of Bone Marrow Stromal Pluripotent Cells in CBA Mice Induced by Each Antigen Separat. Bull Exp Biol Med. 2015;160:256-9 pubmed publisher
    ..of streptococcus antigens, we observed a significant decrease in serum concentrations of IFN-γ, IL-10, GM-CSF, IL-12, and TNF-α, in comparison with injection S...
  33. Gomez Y, Diaz Solano D, Gledhill T, Wittig O, Cardier J. The effect of G-CSF and AMD3100 on mice treated with streptozotocin: Expansion of alpha-cells and partial islet protection. Cytokine. 2017;96:123-131 pubmed publisher
    ..In this work, we evaluated the effects of the hematopoietic mobilizers G-CSF (250?g/kg; for five consecutive days) and AMD3100 (5mg/kg; single s...
  34. Bazett M, Biala A, Huff R, Zeglinksi M, Hansbro P, Bosiljcic M, et al. Attenuating immune pathology using a microbial-based intervention in a mouse model of cigarette smoke-induced lung inflammation. Respir Res. 2017;18:92 pubmed publisher
    ..smoke-induced lung inflammation as shown by reductions in levels of BAL IFNγ, CXCL9, CXCL10, CCL5, IL-6, G-CSF, and IL-17. KB additionally attenuated the quantity of BAL lymphocytes and macrophages...
  35. Suárez M, Sordo Y, Prieto Y, Rodríguez M, Méndez L, Rodríguez E, et al. A single dose of the novel chimeric subunit vaccine E2-CD154 confers early full protection against classical swine fever virus. Vaccine. 2017;35:4437-4443 pubmed publisher
    ..The E2-CD154 immunized animals were able to overcome the challenge with a high virulent CSF virus strain performed 7days after a unique dose of the vaccine without clinical manifestations of the disease...
  36. Shi M, Tang L, Toledo J, Ginghina C, Wang H, Aro P, et al. Cerebrospinal fluid α-synuclein contributes to the differential diagnosis of Alzheimer's disease. Alzheimers Dement. 2018;14:1052-1062 pubmed publisher
    The ability of Alzheimer's disease (AD) cerebrospinal fluid (CSF) biomarkers (amyloid β peptide 1-42, total tau, and phosphorylated tau) to discriminate AD from related disorders is limited...
  37. Yang H, Cai L, Zhang Y, Tan H, Deng Q, Zhao M, et al. Sensitive detection of EGFR mutations in cerebrospinal fluid from lung adenocarcinoma patients with brain metastases. J Mol Diagn. 2014;16:558-563 pubmed publisher
    Epidermal growth factor receptor (EGFR) mutations in cerebrospinal fluid (CSF) might be useful predictive markers for EGFR tyrosine kinase inhibitor treatment of intracranial metastatic tumors...
  38. De Vis J, Zwanenburg J, van der Kleij L, Spijkerman J, Biessels G, Hendrikse J, et al. Cerebrospinal fluid volumetric MRI mapping as a simple measurement for evaluating brain atrophy. Eur Radiol. 2016;26:1254-62 pubmed publisher
    To assess whether volumetric cerebrospinal fluid (CSF) MRI can be used as a surrogate for brain atrophy assessment and to evaluate how the T2 of the CSF relates to brain atrophy...
  39. Panch S, Yau Y, Fitzhugh C, Hsieh M, Tisdale J, Leitman S. Hematopoietic progenitor cell mobilization is more robust in healthy African American compared to Caucasian donors and is not affected by the presence of sickle cell trait. Transfusion. 2016;56:1058-65 pubmed publisher
    Granulocyte-colony-stimulating factor (G-CSF)-stimulated hematopoietic progenitor cells (HPCs) collected by apheresis have become the predominant graft source for HPC transplantation in adults...
  40. Hayek M, Roth C, Kaestner S, Deinsberger W. Impact of External Ventricular Drainage Volumes on Shunt Dependency after Subarachnoid Hemorrhage. J Neurol Surg A Cent Eur Neurosurg. 2017;78:227-230 pubmed publisher
    ..The amount of cerebrospinal fluid (CSF) drained via an external ventricular drain (EVD) may predict shunt dependency...
  41. Ji A, Liu Z, Chen W, Huang W. The clinical significance of level changes of hs-CRP, IL-10 and TNF for patients with MS during active and relieving period. Eur Rev Med Pharmacol Sci. 2016;20:4274-4276 pubmed
    ..Levels of hs-CRP, TNF-a and IL-10 in the serum and cerebral spinal fluid (CSF) were different for MS patient at different stages...
  42. Bandyopadhyay S, Saha M, Chakrabarti A, Sinha A. Effect on contrast sensitivity after clear, yellow and orange intraocular lens implantation. Int Ophthalmol. 2016;36:313-8 pubmed publisher
    The objective of this study is to evaluate contrast sensitivity function (CSF) after clear, yellow- and orange-tinted intraocular lens (IOL) implantation...
  43. Vaithilingam V, Evans M, Lewy D, Bean P, Bal S, Tuch B. Co-encapsulation and co-transplantation of mesenchymal stem cells reduces pericapsular fibrosis and improves encapsulated islet survival and function when allografted. Sci Rep. 2017;7:10059 pubmed publisher
    ..Levels of peritoneal immunomodulatory cytokines IL-4, IL-6, IL-10 and G-CSF were significantly higher in MSC co-encapsulated groups...
  44. Sudam V, Potnuri A, Subhashini N. Syk - GTP RAC-1 mediated immune-stimulatory effect of Cuscuta epithymum, Ipomoea batata and Euphorbia hirta plant extracts. Biomed Pharmacother. 2017;96:742-749 pubmed publisher
    ..by the methanolic extracts was compared with the standard Granulocyte Macrophage - Colony Stimulating Factor (GM-CSF) at a dose of 65ng/ml...
  45. Kushnir M, Peterson L, Strathmann F. Parathyroid hormone related protein concentration in human serum and CSF correlates with age. Clin Biochem. 2018;52:56-60 pubmed publisher
    ..However, there are conflicting reports regarding the presence of PTHrP in CSF. PTHrP and Ca were quantified in paired CSF and serum samples using mass spectrometry-based methods...
  46. Low J, Bartberger M, Cheng Y, Whittington D, Xue Q, Wood S, et al. Diastereoselective synthesis of fused cyclopropyl-3-amino-2,4-oxazine ?-amyloid cleaving enzyme (BACE) inhibitors and their biological evaluation. Bioorg Med Chem Lett. 2018;28:1111-1115 pubmed publisher
    ..When tested in vivo, compound 2 demonstrated a significant reduction of brain and cerebral spinal fluid (CSF) A?40 levels (46% and 66%, respectively) in a rat pharmacodynamic study and thus represents a suitable ..
  47. Wu C, Valerio I, Huang J, Chang K, Cheng M. Refinement of the myocutaneous anterolateral thigh flap for reconstruction of frontonasal fistula defects. Head Neck. 2016;38 Suppl 1:E552-8 pubmed publisher
    ..Complications included a recurrent abscess in 1 case (10%); there were no cases of cerebrospinal fluid (CSF) leak or flap loss...
  48. Kuhle J, Barro C, Disanto G, Mathias A, Soneson C, Bonnier G, et al. Serum neurofilament light chain in early relapsing remitting MS is increased and correlates with CSF levels and with MRI measures of disease severity. Mult Scler. 2016;22:1550-1559 pubmed
    Neurofilament light chain (NfL) levels in the cerebrospinal fluid (CSF) of multiple sclerosis (MS) patients correlate with the degree of neuronal injury...
  49. Fan T, Zhao H, Zhao X, Liang C, Wang Y, Gai Q. Surgical management of Chiari I malformation based on different cerebrospinal fluid flow patterns at the cranial-vertebral junction. Neurosurg Rev. 2017;40:663-670 pubmed publisher
    Chiari I malformation has been shown to present different cerebrospinal fluid (CSF) flow patterns at the cranial-vertebral junction (CVJ). Posterior fossa decompression is the first-line treatment for symptomatic Chiari I malformation...
  50. Singh V, Keisham A, Bhalla A, Sharma N, Agarwal R, Sharma R, et al. Efficacy of Granulocyte Colony-Stimulating Factor and N-Acetylcysteine Therapies in Patients With Severe Alcoholic Hepatitis. Clin Gastroenterol Hepatol. 2018;16:1650-1656.e2 pubmed publisher
    ..Administration of granulocyte colony stimulating factor (G-CSF) increases survival times of patients with AH...
  51. Liu L, Yu Q, Fu S, Wang B, Hu K, Wang L, et al. The CXCR4 antagonist AMD3100 promotes mesenchymal stem cell mobilization in rats preconditioned with the hypoxia-mimicking agent cobalt chloride. Stem Cells Dev. 2018;: pubmed publisher
    ..SDF-1)/CXCR4 axis in the regulation of MSC migration, the effects of granulocyte colony-stimulating factor (G-CSF) and the CXCR4 antagonist AMD3100 were investigated on MSC mobilization...
  52. Santos A, Fonseca Neto R, Veiga J, Viana J, Scaliassi N, Lancellotti C, et al. Endoscopic endonasal transsphenoidal approach for pituitary adenomas: technical aspects and report of casuistic. Arq Neuropsiquiatr. 2010;68:608-12 pubmed
    ..Three patients had diabetes insipidus and 5 had CSF leaks treated with lumbar drainage...
  53. Irani S, Lehmann Horn K, Geschwind M, Wang S, Vincent A, von Büdingen H. The active intrathecal B-cell response in LGI1-antibody encephalitis. Lancet. 2015;385 Suppl 1:S46 pubmed publisher
    ..LGI1-antibody concentrations are 10-100 times greater in serum than in cerebrospinal fluid (CSF). Oligoclonal IgG bands are rarely found in patients with LGI1-antibody encephalitis or epilepsy...
  54. Wang J, Wang S, Zhang W, Wang T, Li P, Zhao X, et al. Proteomic profiling of heat acclimation in cerebrospinal fluid of rabbit. J Proteomics. 2016;144:113-22 pubmed publisher
    ..Conducting a protein profile of cerebrospinal fluid (CSF) can facilitate the understanding of molecular pathways involved in AC and identifying stress-specific proteins as ..
  55. Castiglia D, Posteraro P, Spirito F, Pinola M, Angelo C, Puddu P, et al. Novel mutations in the LAMC2 gene in non-Herlitz junctional epidermolysis bullosa: effects on laminin-5 assembly, secretion, and deposition. J Invest Dermatol. 2001;117:731-9 pubmed
    Laminin-5 is the major adhesion ligand of epithelial cells. Mutations in the three genes (LAMA3, LAMB3, LAMC2) encoding the laminin-5 chains cause junctional epidermolysis bullosa, a clinically and genetically heterogeneous blistering ..
  56. Gray K, Aljabar P, Heckemann R, Hammers A, Rueckert D. Random forest-based similarity measures for multi-modal classification of Alzheimer's disease. Neuroimage. 2013;65:167-75 pubmed publisher
    ..Features include regional MRI volumes, voxel-based FDG-PET signal intensities, CSF biomarker measures, and categorical genetic information...
  57. Yamaguchi T, Takizawa F, Fischer U, Dijkstra J. Along the Axis between Type 1 and Type 2 Immunity; Principles Conserved in Evolution from Fish to Mammals. Biology (Basel). 2015;4:814-59 pubmed publisher
    ..Furthermore, the present study is the first to identify a canonical TH2 cytokine locus in a bony fish, namely spotted gar, in the sense that it includes RAD50 and bona fide genes of both IL-4/13 and IL-3/ IL-5/GM-CSF families.
  58. Panegyres P, Berry R, Burchell J. Early Dementia Screening. Diagnostics (Basel). 2016;6: pubmed publisher
    ..status, corroborative history and imaging (including MRI, FDG-PET and maybe amyloid PET), cerebrospinal fluid (CSF) examination assaying Aβ1-42, T-τ and P-τ might also be helpful...
  59. Kantarci A, Aytan N, Palaska I, Stephens D, Crabtree L, Benincasa C, et al. Combined administration of resolvin E1 and lipoxin A4 resolves inflammation in a murine model of Alzheimer's disease. Exp Neurol. 2018;300:111-120 pubmed publisher
    ..and restored the homeostasis reversing the inflammatory process for inflammatory cytokines and chemokines (GM-CSF, IFN-?, IL-1?, IL-6, IL-10, TNF-?, MCP-1, MIP-1?, MIP-1?, and RANTES) as measured by multiplex immunoassay...
  60. Bucher K, Schmitt F, Mothes B, Blumendeller C, Schall D, Piekorz R, et al. Deficiency of PI3-Kinase catalytic isoforms p110? and p110? in mice enhances the IL-17/G-CSF axis and induces neutrophilia. Cell Commun Signal. 2017;15:28 pubmed publisher
    ..Serum concentrations of IL-17, of the neutrophilic growth factor G-CSF, and of the neutrophil mobilizing CXC chemokines CXCL1/KC and CXCL2/MIP-2 were measured by Bio-Plex assay...
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    ..is a lifesaving procedure but is associated to several post-operative complications, namely cerebrospinal fluid (CSF) dynamics impairment...
  62. Zega K, Jovanovic V, Vitic Z, Niedzielska M, Knaapi L, Jukic M, et al. Dusp16 Deficiency Causes Congenital Obstructive Hydrocephalus and Brain Overgrowth by Expansion of the Neural Progenitor Pool. Front Mol Neurosci. 2017;10:372 pubmed publisher
    ..neural progenitors, and during later gestational stages by neurons resulting in a blockage of cerebrospinal fluid (CSF) outflow. In contrast, the roof plate and ependymal cells developed normally...
  63. Lehmer C, Oeckl P, Weishaupt J, Volk A, Diehl Schmid J, Schroeter M, et al. Poly-GP in cerebrospinal fluid links C9orf72-associated dipeptide repeat expression to the asymptomatic phase of ALS/FTD. EMBO Mol Med. 2017;9:859-868 pubmed publisher
    ..Here, we established a poly-GP immunoassay from cerebrospinal fluid (CSF) to identify and characterize C9orf72 patients...
  64. Guo L, Wang Y, Mei J, Ning R, Wang J, Li J, et al. Pulmonary immune cells and inflammatory cytokine dysregulation are associated with mortality of IL-1R1 -/-mice infected with influenza virus (H1N1). Zool Res. 2017;38:146-154 pubmed publisher
    ..dysregulation were observed with significantly decreased neutrophil infiltration and IL-6, TNF-α, G-CSF, KC, and MIP-2 cytokine levels in the bronchoalveolar lavage fluid of infected IL-1R1 -/- mice in ..
  65. Connolly I, Li Y, Pan W, Johnson E, You L, Vogel H, et al. A pilot study on the use of cerebrospinal fluid cell-free DNA in intramedullary spinal ependymoma. J Neurooncol. 2017;135:29-36 pubmed publisher
    Cerebrospinal fluid (CSF) represents a promising source of cell-free DNA (cfDNA) for tumors of the central nervous system...
  66. Siddiqui J, Johnson J, Le Henaff C, Bitel C, Tamasi J, Partridge N. Catabolic Effects of Human PTH (1-34) on Bone: Requirement of Monocyte Chemoattractant Protein-1 in Murine Model of Hyperparathyroidism. Sci Rep. 2017;7:15300 pubmed publisher
    ..In vitro, bone marrow macrophages (BMMs) from MCP-1-/- and WT mice were cultured with M-CSF, RANKL and/or MCP-1...
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    ..amyloid (Aβ) and tau pathology have been found at autopsy and several studies have reported altered CSF levels of Aβ1-42, total-Tau (t-Tau) and phosphorylated-Tau (p-Tau)...
  68. Dangla Valls A, Molinuevo J, Altirriba J, Sanchez Valle R, Alcolea D, Fortea J, et al. CSF microRNA Profiling in Alzheimer's Disease: a Screening and Validation Study. Mol Neurobiol. 2017;54:6647-6654 pubmed publisher
    ..In the present work, we have studied the expression levels of 754 miRNAs in cerebrospinal fluid (CSF) from AD patients and control subjects...
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    ..but also report high rates of premature rupture of membranes, preterm births, and persistent cerebrospinal fluid (CSF) leakage that requires postnatal revision of the MMC repair...
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    ..into fatigue group and non-fatigue group, and detected the levels of serotonin, iron and related proteins in CSF and serum...
  71. Thaler F, Laurent S, Huber M, Mulazzani M, Dreyling M, Ködel U, et al. Soluble TACI and soluble BCMA as biomarkers in primary central nervous system lymphoma. Neuro Oncol. 2017;19:1618-1627 pubmed publisher
    ..We evaluated the diagnostic potential of soluble TACI (sTACI) and soluble BCMA (sBCMA) in CSF and serum as biomarkers in primary CNS lymphoma (PCNSL)...
  72. Cohen I, Staretz Chacham O, Wormser O, Perez Y, Saada A, Kadir R, et al. A novel homozygous SLC25A1 mutation with impaired mitochondrial complex V: Possible phenotypic expansion. Am J Med Genet A. 2017;: pubmed publisher
    ..Ventricular septal defects (VSD) were demonstrated in three patients. Blood and CSF lactate were elevated with normal levels of plasma amino acids and free carnitine and increased 2-OH-glutaric acid ..
  73. Xuan N, Hoang N, Nhung V, Duong N, Ha N, Hai N. Regulation of dendritic cell function by insulin/IGF-1/PI3K/Akt signaling through klotho expression. J Recept Signal Transduct Res. 2017;37:297-303 pubmed publisher
    ..To this end, the mouse bone marrow cells were isolated and cultured with GM-CSF to attain bone marrow-derived DCs (BMDCs)...
  74. Lerman I, Davis B, Bertram T, Proudfoot J, Hauger R, Coe C, et al. Posttraumatic stress disorder influences the nociceptive and intrathecal cytokine response to a painful stimulus in combat veterans. Psychoneuroendocrinology. 2016;73:99-108 pubmed publisher
    ..Because excessive inflammation occurs in both conditions, we examined the cerebrospinal fluid (CSF) concentrations of inflammatory response mediators interleukin 1-beta (IL-1?), interleukin 6 (IL-6), interleukin 8 (..
  75. Duron L, Sadones F, Thiesse P, Cellier C, Alapetite C, Doz F, et al. Loco-regional extensions of central nervous system germ cell tumors: a retrospective radiological analysis of 100 patients. Neuroradiology. 2018;60:27-34 pubmed publisher
    ..Metastatic disease occurred in 6/100 patients (depicted by MRI in two and CSF cytology in four)...
  76. Armanet M, Wojtusciszyn A, Morel P, Parnaud G, Rousselle P, Sinigaglia C, et al. Regulated laminin-332 expression in human islets of Langerhans. FASEB J. 2009;23:4046-55 pubmed publisher
    ..These results show that LN-332, known to have some beneficial effect on beta cells in vitro, is produced and secreted by endocrine islet cells and is up-regulated by stressing conditions such as culture and IL-1beta-exposure. ..
  77. Cicognola C, Chiasserini D, Eusebi P, Andreasson U, Vanderstichele H, Zetterberg H, et al. No diurnal variation of classical and candidate biomarkers of Alzheimer's disease in CSF. Mol Neurodegener. 2016;11:65 pubmed publisher
    Cerebrospinal fluid (CSF) biomarkers have gained increasing importance in the diagnostic work-up of Alzheimer's disease (AD)...
  78. Scholz T, Weigert A, Brüne B, Sadik C, Böhm B, Burkhardt H. GM-CSF in murine psoriasiform dermatitis: Redundant and pathogenic roles uncovered by antibody-induced neutralization and genetic deficiency. PLoS ONE. 2017;12:e0182646 pubmed publisher
    Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a pleiotropic, Th17-derived cytokine thought to critically contribute to the pathogenesis of diverse autoimmune diseases, including rheumatoid arthritis and psoriasis...
  79. Lobatto D, de Vries F, Zamanipoor Najafabadi A, Pereira A, Peul W, Vliet Vlieland T, et al. Preoperative risk factors for postoperative complications in endoscopic pituitary surgery: a systematic review. Pituitary. 2018;21:84-97 pubmed publisher
    ..associations were older age for complications in general, and intraventricular extension for cerebrospinal fluid (CSF) leaks...
  80. Peres A, Zamboni R, King I, Madrenas J. Suppression of CYP1 members of the AHR response by pathogen-associated molecular patterns. J Leukoc Biol. 2017;102:1471-1480 pubmed publisher
    ..Furthermore, such a split regulation of the AHR response was more apparent in GM-CSF-derived macrophages, a finding corroborated at the functional level by decreased CYP1 activity and decreased ..
  81. Batllori M, Molero Luís M, Ormazabal A, Casado M, Sierra C, Garcia Cazorla A, et al. Analysis of human cerebrospinal fluid monoamines and their cofactors by HPLC. Nat Protoc. 2017;12:2359-2375 pubmed publisher
    ..their cofactors (the pterins and vitamin B6 (pyridoxal phosphate (PLP))) in human cerebrospinal fluid (CSF) can be used as indicators of the biosynthesis and turnover of dopamine and serotonin in the brain...
  82. Vogt N, Kerby R, Dill McFarland K, Harding S, Merluzzi A, Johnson S, et al. Gut microbiome alterations in Alzheimer's disease. Sci Rep. 2017;7:13537 pubmed publisher
    ..Furthermore, we observed correlations between levels of differentially abundant genera and cerebrospinal fluid (CSF) biomarkers of AD...
  83. Omran A, Saternos H, Althobaiti Y, Wisner A, Sari Y, Nauli S, et al. Alcohol consumption impairs the ependymal cilia motility in the brain ventricles. Sci Rep. 2017;7:13652 pubmed publisher
    ..protrude into the central canal of the brain ventricles and spinal cord to circulate the cerebral spinal fluid (CSF)...
  84. Vieira E, Guimarães T, Faquini I, Silva J, Saboia T, Andrade R, et al. Randomized controlled study comparing 2 surgical techniques for decompressive craniectomy: with watertight duraplasty and without watertight duraplasty. J Neurosurg. 2017;:1-7 pubmed publisher
    ..The primary end point was the incidence of surgical complications (CSF leak, wound infection, brain abscess, or subgaleal fluid collections)...
  85. Van der Spek A, Jim K, Karaczyn A, van Beeren H, Ackermans M, Darras V, et al. The Thyroid Hormone Inactivating Type 3 Deiodinase Is Essential for Optimal Neutrophil Function: Observations From Three Species. Endocrinology. 2018;159:826-835 pubmed publisher
    ..We measured TH concentrations in cerebrospinal fluid (CSF) from patients with bacterial meningitis and controls...
  86. Wright S, Trauernicht A, Bonkowski E, McCall C, Maier E, Bezold R, et al. Familial Association of Granulocyte-Macrophage Colony Stimulating Factor Autoantibodies in Inflammatory Bowel Disease. J Pediatr Gastroenterol Nutr. 2017;: pubmed publisher
    Elevated Granulocyte-Macrophage Colony Stimulating Factor auto-antibodies (GM-CSF Ab) are associated with increased intestinal permeability and stricturing behavior in Crohn's Disease (CD)...
  87. Katayama M, Sanzen N, Funakoshi A, Sekiguchi K. Laminin gamma2-chain fragment in the circulation: a prognostic indicator of epithelial tumor invasion. Cancer Res. 2003;63:222-9 pubmed
    ..These data reveal that the level of circulating G2F is a new, prognostic, tumor-characterizing marker for estimating the invasiveness and malignancy of epithelial carcinomas in cancer patients. ..
  88. Scharf E, Hanson C, Howard M, Keegan B. Serial cerebrospinal fluid examinations to diagnose hematological malignancy causing neurological disease. J Neurooncol. 2016;129:77-83 pubmed publisher
    To determine the diagnostic utility of serial cerebrospinal fluid (CSF) examinations for hematological malignancy causing neurological disease...
  89. Kim H, Ohk B, Yoon H, Kang W, Seong S, Kim S, et al. Docosahexaenoic acid signaling attenuates the proliferation and differentiation of bone marrow-derived osteoclast precursors and promotes apoptosis in mature osteoclasts. Cell Signal. 2017;29:226-232 pubmed publisher
    ..DHA suppressed the macrophage colony-stimulating factor (M-CSF)-induced proliferation of osteoclast precursors, BMMs, in a dose-dependent manner...
  90. Stephenson G, Morris K, O Neil T, Bruce M, Strom A, Bean A. Characterisation of the porcine cytokines which activate the CD131βc common sub-unit, for potential immune-augmentation. Cytokine. 2018;102:131-140 pubmed publisher
    ..Thus far, the recombinant Po (rPo) Granulocyte-macrophage colony-stimulating factor (GM-CSF), rPo interleukin-3 (IL-3) and rPo interleukin-5 (IL-5) proteins have been identified and cloned and the biological ..
  91. Feldman R, Bakermans Kranenburg M. Oxytocin: a parenting hormone. Curr Opin Psychol. 2017;15:13-18 pubmed publisher
    ..last decade, studies have begun to examine peripheral levels of OT - in plasma, saliva, urine, and to lesser extend CSF - in humans as well as OT administration to parents...
  92. Lee C, Mokhtari T, Connolly I, Li G, Shuer L, Chang S, et al. Comparison of Porcine and Bovine Collagen Dural Substitutes in Posterior Fossa Decompression for Chiari I Malformation in Adults. World Neurosurg. 2017;108:33-40 pubmed publisher
    ..are susceptible to postoperative complications such as pseudomeningocele, external cerebrospinal fluid (CSF) leak, and meningitis. Various dural substitutes have been used to improve surgical outcomes...