LAMA1

Summary

Gene Symbol: LAMA1
Description: laminin subunit alpha 1
Alias: LAMA, PTBHS, S-LAM-alpha, laminin subunit alpha-1, S-LAM alpha, S-laminin subunit alpha, laminin A chain, laminin, alpha 1, laminin-3 subunit alpha
Species: human
Products:     LAMA1

Top Publications

  1. Haaparanta T, Uitto J, Ruoslahti E, Engvall E. Molecular cloning of the cDNA encoding human laminin A chain. Matrix. 1991;11:151-60 pubmed
    ..We report here the isolation and nucleotide sequence of human laminin A chain cDNA. The nucleotide sequence spans 9505 bases and has an open reading frame encoding 3075-amino acids...
  2. Nissinen M, Vuolteenaho R, Boot Handford R, Kallunki P, Tryggvason K. Primary structure of the human laminin A chain. Limited expression in human tissues. Biochem J. 1991;276 ( Pt 2):369-79 pubmed
    cDNA clones for the human laminin A chain were isolated from libraries prepared from human gestational choriocarcinoma cell line (JAR) RNA. They cover approx. 8 kb from the 5'-end of the 9.5 kb mRNA coding for this protein...
  3. Nagayoshi T, Mattei M, Passage E, Knowlton R, Chu M, Uitto J. Human laminin A chain (LAMA) gene: chromosomal mapping to locus 18p11.3. Genomics. 1989;5:932-5 pubmed
    ..We have recently isolated cDNAs corresponding to human laminin A chain. These cDNAs were utilized for chromosomal in situ hybridizations to establish the genomic location of the ..
  4. Akasaka H, Katsuya T, Saitoh S, Sugimoto K, Ohnishi H, Congrains A, et al. A promoter polymorphism of lamin A/C gene is an independent genetic predisposition to arterial stiffness in a Japanese general population (the Tanno and Sobetsu study). J Atheroscler Thromb. 2009;16:404-9 pubmed
    ..Promoter -1030C/T polymorphism of LMNA is a possible genetic predisposition to arterial stiffness in the Japanese population. ..
  5. Yoon K, Park J, Han J, Park S, Lee G, Han J, et al. A genome-wide association study reveals susceptibility variants for non-small cell lung cancer in the Korean population. Hum Mol Genet. 2010;19:4948-54 pubmed publisher
    ..This high-density large-scale GWAS carried out in the Korean population suggests that 3q29 is a novel susceptibility region associated with lung cancer susceptibility in Koreans. ..
  6. Koehler A, Rashid M, Zhang Y, Vaughan J, Gasser R, Jabbar A. First cross-sectional, molecular epidemiological survey of Cryptosporidium, Giardia and Enterocytozoon in alpaca (Vicugna pacos) in Australia. Parasit Vectors. 2018;11:498 pubmed publisher
    ..in neonatal diarrhoea, leading to marked morbidity and mortality in the alpaca (Vicugna pacos) and llama (Lama glama) around the world...
  7. Jin R, Wu P, Ho J, Wang X, Han C. Five-year epidemiology of liquefied petroleum gas-related burns. Burns. 2018;44:210-217 pubmed publisher
    ..0001) than that of the medical insurance group. In addition, 72.73% of patients who left against medical advice (LAMA) were uninsured. The number of patients who recovered at our hospital was 165 (84.62%), while 22 patients (11...
  8. Jia R, Lan C, Wang X, Gao C. Integrated analysis of gene expression and copy number variations in MET proto?oncogene?transformed human primary osteoblasts. Mol Med Rep. 2017;: pubmed publisher
    ..Therefore, cell cycle?associated genes including E2F1, E2F2, RB1 and CCND1, and cell adhesion?associated genes, such as CDH18 and LAMA1 may be used as diagnosis and/or therapeutic markers for patients with OS.
  9. Fijačko V, Labor M, Fijačko M, Škrinjarić Cincar S, Labor S, Dumbović Dubravčić I, et al. Predictors of short-term LAMA ineffectiveness in treatment naïve patients with moderate to severe COPD. Wien Klin Wochenschr. 2018;130:247-258 pubmed publisher
    ..001). Our results suggest that there is a possibility to identify predictors of short-term tiotropium ineffectiveness in patients with moderate to severe COPD. ..

More Information

Publications137 found, 100 shown here

  1. Namba Y, Togo S, Tulafu M, Kadoya K, Nagahama K, Taka H, et al. Combination of glycopyrronium and indacaterol inhibits carbachol-induced ERK5 signal in fibrotic processes. Respir Res. 2017;18:46 pubmed publisher
    ..This study was designed to examine the effects of a long-acting muscarinic receptor antagonist (LAMA) glycopyrronium and a long-acting ?2 adrenergic receptor agonist (LABA) indacaterol on acetylcholine-mediated ..
  2. Mann V, Grimm D, Corydon T, Kruger M, Wehland M, Riwaldt S, et al. Changes in Human Foetal Osteoblasts Exposed to the Random Positioning Machine and Bone Construct Tissue Engineering. Int J Mol Sci. 2019;20: pubmed publisher
    ..SRY-Box 9 (SOX9), actin beta (ACTB), beta tubulin (TUBB), vimentin (VIM), laminin subunit alpha 1 (LAMA1), collagen type 1 alpha 1 (COL1A1), phosphoprotein 1 (SPP1) and fibronectin 1 ..
  3. Graubner F, Boos A, Aslan S, Kücükaslan I, Kowalewski M. Uterine and placental distribution of selected extracellular matrix (ECM) components in the dog. Reproduction. 2018;155:403-421 pubmed publisher
    ..e. COL1, -3, -4 and LAMA2) from pre-implantation toward post-implantation at placentation sites appears to be associated with ..
  4. Xue M, Gong S, Dai J, Chen G, Hu J. The Treatment of Fibrosis of Joint Synovium and Frozen Shoulder by Smad4 Gene Silencing in Rats. PLoS ONE. 2016;11:e0158093 pubmed publisher
    ..It significantly inhibited the increase of the Vimentin, ?-SMA, collagen I and III, Lama1 and Timp1 proteins in synovial tissue as well as the inflammatory factors of TNF-a, IL-1?/?, IL-6 and IL-10 in ..
  5. Ichinose M, Minakata Y, Motegi T, Ueki J, Seki T, Anzai T, et al. Study Design of VESUTO®: Efficacy of Tiotropium/Olodaterol on Lung Hyperinflation, Exercise Capacity, and Physical Activity in Japanese Patients with Chronic Obstructive Pulmonary Disease. Adv Ther. 2017;34:1622-1635 pubmed publisher
    ..The study could provide additional evidence of long-acting muscarinic antagonist (LAMA) + long-acting β2-agonist (LABA) combination therapy on patients' physical activities as well as lung ..
  6. Hernandez J, Campos C, Borghi C. Medicinal use of wild fauna by mestizo communities living near San Guillermo Biosphere Reserve (San Juan, Argentina). J Ethnobiol Ethnomed. 2015;11:15 pubmed publisher
    ..Seven species were mentioned: Rhea pennata, Lama guanicoe, Puma concolor, Pseudalopex sp., Lama vicugna, Lepus europaeus and Conepatus chinga...
  7. Ceccon M, Mauri M, Massimino L, Giudici G, Piazza R, Gambacorti Passerini C, et al. Mitochondrial Hyperactivation and Enhanced ROS Production are Involved in Toxicity Induced by Oncogenic Kinases Over-Signaling. Cancers (Basel). 2018;10: pubmed publisher
    ..The two models utilized (LAMA and SUP-M2) differed in having oncogene overexpression as the sole cause of drug resistance (CML), or additionally ..
  8. Jafari Andarian S, Olyaeemanesh A, Hosseini S, Akbari Sari A, Firoozbakhsh S, Nouhi Jadesi M, et al. The safety and effectiveness of the current treatment regimen with or without roflumilast in advanced COPD patients: A systematic review and meta-analysis of randomized controlled trials. Med J Islam Repub Iran. 2016;30:332 pubmed
    ..and safety of roflumilast as concomitant to Long-acting ß2-agonist/Long-acting muscarinic antagonist (LABA/LAMA) regimen, in adult patients with severe COPD...
  9. Milara J, Cervera A, de Diego A, Sanz C, Juan G, Gavaldá A, et al. Non-neuronal cholinergic system contributes to corticosteroid resistance in chronic obstructive pulmonary disease patients. Respir Res. 2016;17:145 pubmed
    ..By contrast, the recommendation of ICS in combination with long-acting muscarinic antagonist (LAMA) is not evidence-based...
  10. Rocha M, Arcanjo R, Lopes C, Carneiro M, Souza A, Báo S. Modulation of fibronectin and laminin expression by Rhodium (II) citrate-coated maghemite nanoparticles in mice bearing breast tumor. Sci Rep. 2017;7:17904 pubmed publisher
    ..The gene expression of FN1 and LAMA1 were evaluated using real-time PCR...
  11. Driessen M, Whalen J, Seewoodharry Buguth B, Vallejo Aparicio L, Naya I, Asukai Y, et al. Cost-effectiveness analysis of umeclidinium bromide/vilanterol 62.5/25 mcg versus tiotropium/olodaterol 5/5 mcg in symptomatic patients with chronic obstructive pulmonary disease: a Spanish National Healthcare System perspective. Respir Res. 2018;19:224 pubmed publisher
    ..These results may aid payers and decision-makers in Spain when making judgements on which long-acting muscarinic antagonist/long-acting β2-agonist (LAMA/LABA) treatments can be considered cost effective in Spain.
  12. Zysman M, Chabot F, Devillier P, Housset B, Morelot Panzini C, Roche N. Pharmacological treatment optimization for stable chronic obstructive pulmonary disease. Proposals from the Société de Pneumologie de Langue Française. Rev Mal Respir. 2016;33:911-936 pubmed publisher
    ..and/or exacerbations, a long-acting bronchodilator should be suggested (beta-2 agonist, LABA or anticholinergics, LAMA)...
  13. Araújo D, Padrão E, Morais Almeida M, Cardoso J, Pavão F, Leite R, et al. Asthma-chronic obstructive pulmonary disease overlap syndrome - Literature review and contributions towards a Portuguese consensus. Rev Port Pneumol (2006). 2017;23:90-99 pubmed publisher
    ..association; if symptomatic control is not achieved or in case of clinical severity, triple therapy with ICS/LABA/LAMA may be used...
  14. Padrão E, Araújo D, Todo Bom A, Robalo Cordeiro C, Correia de Sousa J, Cardoso J, et al. Asthma-COPD overlap: A Portuguese survey. Pulmonology. 2018;: pubmed publisher
    ..of inhaled corticosteroid (ICS) with long-acting beta2-agonist (LABA) or long-acting muscarinic antagonist (LAMA) was considered as first line pharmacological treatment...
  15. Allen A, Stanton J, Evermann J, Fry L, Ackerman M, Barrington G. Bluetongue disease and seroprevalence in South American camelids from the northwestern region of the United States. J Vet Diagn Invest. 2015;27:226-30 pubmed publisher
    ..A 9-year-old intact male llama (Lama glama), with a 1-day history of anorexia, recumbency, and dyspnea before death...
  16. Shrestha A, P Gupta B, K Lama T. Current Treatment of Acute and Chronic Hepatitis E Virus Infection: Role of Antivirals. Euroasian J Hepatogastroenterol. 2017;7:73-77 pubmed publisher
    ..b>How to cite this article: Shrestha A, Gupta BP, Lama TK. Current Treatment of Acute and Chronic Hepatitis E Virus Infection: Role of Antivirals...
  17. Li Y, Yang J, Chen Z, Qin G, Li Y, Li Q, et al. Anaplasma infection of Bactrian camels (Camelus bactrianus) and ticks in Xinjiang, China. Parasit Vectors. 2015;8:313 pubmed publisher
    ..been reported to be a subclinical disease in Indian and Arabian one-humped camels (Camelus dromedarius) and llamas (Lama glama)...
  18. Chen C, Lin S, Chern S, Wu P, Chen S, Lai S, et al. A 13-year-old girl with 18p deletion syndrome presenting Turner syndrome-like clinical features of short stature, short webbed neck, low posterior hair line, puffy eyelids and increased carrying angle of the elbows. Taiwan J Obstet Gynecol. 2018;57:583-587 pubmed publisher
    ..hg19)] encompassing 52 Online Mendelian Inheritance in Man (OMIM) genes including USP14, TYMS, SMCHD1, TGIF1, LAMA1, TWSG1, GNAL and PTPN2. Polymorphic DNA marker analysis revealed a maternal origin of the deletion...
  19. Haaß W, Kleiner H, Weiß C, Haferlach C, Schlegelberger B, Müller M, et al. Clonal Evolution and Blast Crisis Correlate with Enhanced Proteolytic Activity of Separase in BCR-ABL b3a2 Fusion Type CML under Imatinib Therapy. PLoS ONE. 2015;10:e0129648 pubmed publisher
    ..of Separase as measured with a specific fluorogenic assay on CML cell lines (b2a2: KCL-22, BV-173; b3a2: K562, LAMA-84). Despite a drop in Separase protein levels an up to 5...
  20. Aaron S. Management and prevention of exacerbations of COPD. BMJ. 2014;349:g5237 pubmed publisher
    ..Long acting β agonist (LABA) or long acting anti-muscarinic (LAMA) bronchodilators and inhaled corticosteroid-LABA combinations prevent exacerbations in patients at risk, with ..
  21. Milani G, Lana T, Bresolin S, Aveic S, Pastò A, Frasson C, et al. Expression Profiling of Circulating Microvesicles Reveals Intercellular Transmission of Oncogenic Pathways. Mol Cancer Res. 2017;15:683-695 pubmed publisher
    ..Several leukemic cells (K562, LAMA-87, TOM-1, REH, and SHI-1), each carrying a specific chromosomal translocation, were analyzed...
  22. Singh D, Miravitlles M, Vogelmeier C. Chronic Obstructive Pulmonary Disease Individualized Therapy: Tailored Approach to Symptom Management. Adv Ther. 2017;34:281-299 pubmed publisher
    ..Dual bronchodilator therapy with a long-acting muscarinic antagonist (LAMA) and long-acting beta agonist (LABA) has the potential to treat the symptoms of COPD in addition to improving lung ..
  23. Halpin D, Kaplan A, Russell R. Why choose tiotropium for my patient? A comprehensive review of actions and outcomes versus other bronchodilators. Respir Med. 2017;128:28-41 pubmed publisher
    ..Desirable attributes of a long-acting muscarinic antagonist (LAMA) maintenance therapy include effective pharmacological bronchodilation, improved lung function, exacerbation ..
  24. Montes de Oca M, López Varela M, Acuña A, Schiavi E, Rey M, Jardim J, et al. ALAT-2014 Chronic Obstructive Pulmonary Disease (COPD) Clinical Practice Guidelines: questions and answers. Arch Bronconeumol. 2015;51:403-16 pubmed publisher
    ..In stable COPD, similar benefits in dyspnea, pulmonary function and quality of life are achieved with LAMA or LABA long-acting bronchodilators, whereas LAMA is more effective in preventing exacerbations...
  25. Al Faqawi M, Abuowda Y, Elmassry A, Bottcher B. Management of chronic obstructive pulmonary disease exacerbations at the Nasser Medical Complex: a clinical audit. Lancet. 2018;391 Suppl 2:S5 pubmed publisher
    ..43 (78%) received short-acting muscarinic agonists (SAMA), 13 (24%) received long-acting muscarinic agonists (LAMA), one (2%) received long-acting beta-agonists (LABA), and 22 (40%) received both SABA and SAMA...
  26. Takegahara K, Usuda J, Inoue T, Ibi T, Sato A. Preoperative management using inhalation therapy for pulmonary complications in lung cancer patients with chronic obstructive pulmonary disease. Gen Thorac Cardiovasc Surg. 2017;65:388-391 pubmed publisher
    ..2%), compared with the frequency among non-COPD patients (15/224 cases, 6.7%). Inhaled bronchodilators, such as LAMA or LABA, were prescribed for 34 of the 108 patients with COPD; the remaining 74 patients were not treated with ..
  27. van der Schans S, Goossens L, Boland M, Kocks J, Postma M, van Boven J, et al. Systematic Review and Quality Appraisal of Cost-Effectiveness Analyses of Pharmacologic Maintenance Treatment for Chronic Obstructive Pulmonary Disease: Methodological Considerations and Recommendations. Pharmacoeconomics. 2017;35:43-63 pubmed publisher
    ..Papers reported the cost effectiveness of long-acting muscarinic antagonist (LAMA) monotherapy (n = 6), phosphodiesterase (PDE)-4 inhibitors (n = 4), long-acting beta agonist/inhaled ..
  28. Corsonello A, Scarlata S, Pedone C, Bustacchini S, Fusco S, Zito A, et al. Treating COPD in Older and Oldest Old Patients. Curr Pharm Des. 2015;21:1672-89 pubmed
    ..Inhaled long acting betaagonists (LABA) and anticholinergics (LAMA) are the mainstay of therapy in stable COPD, but it should be considered that pharmacological response and safety ..
  29. Hsiao Y, Tseng C, Su K, Chen W, Wu M, Wu Y, et al. Glycopyrronium bromide inhibits lung inflammation and small airway remodeling induced by subchronic cigarette smoke exposure in mice. Respir Physiol Neurobiol. 2018;249:16-22 pubmed publisher
    ..We exposed the mice to CS for four weeks with daily treatment with a LAMA (glycopyrronium bromide, NVA237) or its vehicle...
  30. Sun Y, Cooper M, Finch S, Lin H, Chen Z, Williams B, et al. Rest-mediated regulation of extracellular matrix is crucial for neural development. PLoS ONE. 2008;3:e3656 pubmed publisher
    ..We also show that these Rest-null phenotypes are due to the dysregulation of its direct or indirect target genes, Lama1, Lamb1, Lamc1 and Lama2 and that these aberrant phenotypes can be rescued by laminins.
  31. Ramadan W, Kabbara W, El Khoury G, Al Assir S. Combined bronchodilators (tiotropium plus olodaterol) for patients with chronic obstructive pulmonary disease. Int J Chron Obstruct Pulmon Dis. 2015;10:2347-56 pubmed publisher
    ..Tiotropium, a once-daily dosing LAMA, demonstrated sustained improvements in lung function as well as improved health-related quality of life, reduced ..
  32. Fabris A, Bruschi M, Santucci L, Candiano G, Granata S, Dalla Gassa A, et al. Proteomic-based research strategy identified laminin subunit alpha 2 as a potential urinary-specific biomarker for the medullary sponge kidney disease. Kidney Int. 2017;91:459-468 pubmed publisher
    ..Eventually, 16 proteins were found to be common to three statistical methods with laminin subunit alpha 2 (LAMA-2) reaching the higher rank by a Support Vector Machine, a binary classification/prediction scheme...
  33. Wu C, Liu H, Zhang F, Shao W, Yang L, Ning Y, et al. Long noncoding RNA expression profile reveals lncRNAs signature associated with extracellular matrix degradation in kashin-beck disease. Sci Rep. 2017;7:17553 pubmed publisher
    ..In the network, FBLN1 and LAMA 4 were the core genes with the highest significance...
  34. Hohlfeld J, Vogel Claussen J, Biller H, Berliner D, Berschneider K, Tillmann H, et al. Effect of lung deflation with indacaterol plus glycopyrronium on ventricular filling in patients with hyperinflation and COPD (CLAIM): a double-blind, randomised, crossover, placebo-controlled, single-centre trial. Lancet Respir Med. 2018;6:368-378 pubmed publisher
    ..The combination of a long-acting β agonist (LABA) and a muscarinic antagonist (LAMA) is more effective in reducing hyperinflation than LABA-inhaled corticosteroid combination therapy but whether dual ..
  35. Palu E, Liesi P. Differential distribution of laminins in Alzheimer disease and normal human brain tissue. J Neurosci Res. 2002;69:243-56 pubmed
  36. Carretero M, Fumuso F, Neild D, Giuliano S, Cetica P, Miragaya M. Evaluation of the acrosomal status in Lama glama sperm incubated with acrosome reaction inducers. Anim Reprod Sci. 2015;160:1-11 pubmed publisher
    ..64; P = 0.000) in all the evaluated samples. the FITC-PNA/PI technique simultaneously evaluates viability and acrosomal status in llama spermatozoa and calcium ionophore could be used as a control of AR. ..
  37. Calzetta L, Rogliani P, Matera M, Cazzola M. A Systematic Review With Meta-Analysis of Dual Bronchodilation With LAMA/LABA for the Treatment of Stable COPD. Chest. 2016;149:1181-96 pubmed publisher
    The wide availability of long-acting muscarinic antagonist (LAMA)/long-acting β2-agonist (LABA) fixed-dose combinations (FDCs) in the absence of head-to-head comparative pragmatic trials makes it difficult to choose which combination ..
  38. Shibata Y. [Role of ICS/LABA on COPD treatment]. Nihon Rinsho. 2016;74:827-32 pubmed
    ..of chronic obstructive pulmonary disease (COPD), bronchodilators such as long acting muscarinic antagonist (LAMA) and long acting ? agonist(LABA) play key roles for improving respiratory function and symptoms, and reducing risk ..
  39. Pauciullo A, Gauly M, Cosenza G, Wagner H, Erhardt G. Lama glama ?S1-casein: Identification of new polymorphisms in the CSN1S1 gene. J Dairy Sci. 2017;100:1282-1289 pubmed publisher
    South American camelids have been poorly genetically investigated and little information is available in llamas (Lama glama) regarding the diversity of the caseins at the protein and gene level...
  40. Thomson N. New and developing non-adrenoreceptor small molecule drugs for the treatment of asthma. Expert Opin Pharmacother. 2017;18:283-293 pubmed publisher
    ..include leukotriene-receptor antagonists, slow-release theophylline and the long-acting muscarinic antagonist (LAMA) tiotropium (approved in 2015)...
  41. Takahashi R, Castilho N, Silva M, Miotto M, Lima A. Prospecting for Marine Bacteria for Polyhydroxyalkanoate Production on Low-Cost Substrates. Bioengineering (Basel). 2017;4: pubmed publisher
    ..Among the organisms studied, two isolates, LAMA 677 and LAMA 685, showed strong potential to produce PHA with the use of glycerol as the carbon source, and were ..
  42. Fugassa M. Checklist of helminths found in Patagonian wild mammals. Zootaxa. 2015;4012:271-328 pubmed publisher
    ..In addition, many studies were made on a few species and, for example, 52% corresponded to studies made on Lama guanicoe...
  43. Miravitlles M, D Urzo A, Singh D, Koblizek V. Pharmacological strategies to reduce exacerbation risk in COPD: a narrative review. Respir Res. 2016;17:112 pubmed publisher
    ..gt;1 exacerbation/year) we propose initial bronchodilator treatment with a long-acting muscarinic antagonist (LAMA)/ long-acting β2-agonist (LABA)...
  44. Derom E, Brusselle G, Joos G. Efficacy of tiotropium-olodaterol fixed-dose combination in COPD. Int J Chron Obstruct Pulmon Dis. 2016;11:3163-3177 pubmed publisher
    ..the Respimat soft-mist inhaler, is an inhaled fixed-dose combination (FDC) of a long-acting muscarinic antagonist (LAMA) and a long-acting ?2-agonist (LABA), commercialized under the name of Spiolto or Stiolto...
  45. Adkins D, Clark S, Aberg K, Hettema J, Bukszar J, McClay J, et al. Genome-wide pharmacogenomic study of citalopram-induced side effects in STAR*D. Transl Psychiatry. 2012;2:e129 pubmed publisher
    ..22 × 10(-7), q=0.096). Suggestive findings were also found for SNPs at LAMA1, AOX2P, EGFLAM, FHIT and RTP2...
  46. Chen X, Li G, Li Q, Hu C, Qiu S, Jiang Y, et al. Enteractinococcus lamae sp. nov. and Enteractinococcus viverrae sp. nov., isolated from animal faeces. Antonie Van Leeuwenhoek. 2015;108:1477-1483 pubmed publisher
    Two novel actinobacteria, designated strains YIM 101617(T) and YIM 101632(T), were isolated from Lama pacos (alpaca) and Viverra zibetha (civet) faeces in Yunnan Wild Animal Park in Yunnan province, southwestern China...
  47. Ismaila A, Huisman E, Punekar Y, Karabis A. Comparative efficacy of long-acting muscarinic antagonist monotherapies in COPD: a systematic review and network meta-analysis. Int J Chron Obstruct Pulmon Dis. 2015;10:2495-517 pubmed publisher
    Randomized, controlled trials comparing long-acting muscarinic antagonist (LAMA) efficacy in COPD are limited...
  48. Singh D, Schröder Babo W, Cohuet G, Muraro A, Bonnet Gonod F, Petruzzelli S, et al. The bronchodilator effects of extrafine glycopyrronium added to combination treatment with beclometasone dipropionate plus formoterol in COPD: A randomised crossover study (the TRIDENT study). Respir Med. 2016;114:84-90 pubmed publisher
    ..placebo-controlled, crossover study aimed to determine the dose-response of the long-acting muscarinic antagonist (LAMA) glycopyrronium bromide (GB) when added to beclometasone dipropionate plus formoterol fumarate (BDP/FF) in patients ..
  49. Mahler D, Gifford A, Satti A, Jessop N, Eckert J, D Andrea P, et al. Long-term safety of glycopyrrolate: A randomized study in patients with moderate-to-severe COPD (GEM3). Respir Med. 2016;115:39-45 pubmed publisher
    ..GEM3 (Glycopyrrolate Effect on syMptoms and lung function) study assessed the long-term safety and efficacy of a LAMA, glycopyrrolate (GLY) 15.6 ?g twice daily (b.i.d...
  50. Su V, Yang K, Yang Y, Tsai Y, Perng D, Su W, et al. Use of ICS/LABA Combinations or LAMA Is Associated with a Lower Risk of Acute Exacerbation in Patients with Coexistent COPD and Asthma. J Allergy Clin Immunol Pract. 2018;6:1927-1935.e3 pubmed publisher
    ..85 years. After adjustment, hazard ratios (HRs) for long-acting muscarinic antagonist (LAMA) and inhaled corticosteroid/long-acting β2-agonist (ICS/LABA) combinations were lower (time-dependent ..
  51. Durbeej M, Talts J, Henry M, Yurchenco P, Campbell K, Ekblom P. Dystroglycan binding to laminin alpha1LG4 module influences epithelial morphogenesis of salivary gland and lung in vitro. Differentiation. 2001;69:121-34 pubmed
  52. Bodzenta Łukaszyk A, Fal A, Jassem E, Kowalski M, Kuna P, Kupczyk M. The statement of the Polish Society of Allergology experts on the treatment of difficult-to-treat asthma. Pneumonol Alergol Pol. 2015;83:324-34 pubmed publisher
    ..for patients with asthma include: ultra-long-acting beta2-agonists, long-acting muscarine receptor antagonists (LAMA), monoclonal antibodies, and non-pharmacological interventions...
  53. Meng X, Chen X, Lu P, Ma W, Yue D, Song L, et al. MicroRNA-202 inhibits tumor progression by targeting LAMA1 in esophageal squamous cell carcinoma. Biochem Biophys Res Commun. 2016;473:821-827 pubmed publisher
    ..Furthermore, laminin α1 (LAMA1) expression was frequently positive in ESCC tissues and inversely correlated with miR-202 expression...
  54. Florea F, Koch M, Hashimoto T, Sitaru C. Autoimmunity against laminins. Clin Immunol. 2016;170:39-52 pubmed publisher
  55. Parillo F, Vullo C, Catone G, Miano A, Gobbetti A, Zerani M. Immunolocalisation of nitric oxide synthase isoforms in the ductuli efferentes and epididym. Folia Morphol (Warsz). 2017;76:603-607 pubmed publisher
    ..Our data provide evidence that NOS isoforms may have roles in reproductive functions and in the developmental processes of the excurrent duct system in the alpaca. ..
  56. Virtanen I, Gullberg D, Rissanen J, Kivilaakso E, Kiviluoto T, Laitinen L, et al. Laminin alpha1-chain shows a restricted distribution in epithelial basement membranes of fetal and adult human tissues. Exp Cell Res. 2000;257:298-309 pubmed
    ..The results suggest that outside the central nervous system, Ln alpha1 chain shows a restricted and developmentally regulated expression in BMs of distinct epithelial tissues. ..
  57. D Urzo T, Donohue J, Price D, Miravitlles M, Kerwin E. Dual bronchodilator therapy with aclidinium bromide/formoterol fumarate for chronic obstructive pulmonary disease. Expert Rev Respir Med. 2015;9:519-32 pubmed publisher
    ..antagonists (LAMAs) and long-acting β2 adrenergic receptor agonists (LABAs) may provide additional benefit over LAMA or LABA monotherapy without additive effects on safety and tolerability...
  58. Wilson M, Patel J, Coleman A, McDade C, Stanford R, Earnshaw S. Cost-effectiveness analysis of umeclidinium/vilanterol for the management of patients with moderate to very severe COPD using an economic model. Int J Chron Obstruct Pulmon Dis. 2017;12:997-1008 pubmed publisher
    ..Dual bronchodilation with umeclidinium/vilanterol (UMEC/VI; 62.5/25 ?g) is a novel LAMA/LABA combination approved for maintenance treatment for patients with COPD...
  59. Aalbers R, Park H. Positioning of Long-Acting Muscarinic Antagonists in the Management of Asthma. Allergy Asthma Immunol Res. 2017;9:386-393 pubmed publisher
    ..Long-acting muscarinic antagonist (LAMA) bronchodilators offer a well-tolerated, efficacious, and cost-effective add-on to a patient's treatment...
  60. Legrand A. [Treatment of stable COPD : GOLD 2017 and the associations…]. Rev Med Brux. 2017;38:307-312 pubmed
    ..A clinically important effect was more frequently reached with LABA+LAMA combination than with either medication alone...
  61. Deas S, Huprikar N. Dual bronchodilator therapy for chronic obstructive pulmonary disease: evidence for the efficacy and Safety of fixed dose combination treatments in the setting of recent guideline updates. Curr Opin Pulm Med. 2018;24:130-137 pubmed publisher
    Recent updates to the GOLD guidelines emphasize the use of combination LABA and LAMA bronchodilators for patients with chronic obstructive pulmonary disease with persistent dyspnea despite monotherapy or frequent exacerbations despite ..
  62. Liu L, Fu Y, Zhu F, Mu C, Li R, Song W, et al. Transcriptomic analysis of Portunus trituberculatus reveals a critical role for WNT4 and WNT signalling in limb regeneration. Gene. 2018;658:113-122 pubmed publisher
    ..cell differentiation, muscle growth, moult, metabolism, and immune-related genes upregulated, including WNT4, LAMA, FIP2, FSTL5, TNC, HUS1, SWI5, NCGL, SLC22, PLA2, Tdc2, SMOX, GDH, and SMPD4...
  63. Leivo I, Engvall E. C3d fragment of complement interacts with laminin and binds to basement membranes of glomerulus and trophoblast. J Cell Biol. 1986;103:1091-100 pubmed
    ..Such interactions between C3 and components of the glomerular basement membrane could play important roles in complement-related pathological processes of the glomerulus. ..
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