lactoferrin

Summary

Gene Symbol: lactoferrin
Description: lactotransferrin
Alias: GIG12, HEL110, HLF2, lactotransferrin, epididymis luminal protein 110, growth-inhibiting protein 12, kaliocin-1, lactoferricin, lactoferroxin, neutrophil lactoferrin, talalactoferrin
Species: human
Products:     lactoferrin

Top Publications

  1. Penco S, Scarfi S, Giovine M, Damonte G, Millo E, Villaggio B, et al. Identification of an import signal for, and the nuclear localization of, human lactoferrin. Biotechnol Appl Biochem. 2001;34:151-9 pubmed
    Many different unique functions have been attributed to lactoferrin (Lf), including DNA and RNA binding, and transport into the nucleus, where Lf binds to specific sequences and activates transcription...
  2. Iijima H, Tomizawa Y, Iwasaki Y, Sato K, Sunaga N, Dobashi K, et al. Genetic and epigenetic inactivation of LTF gene at 3p21.3 in lung cancers. Int J Cancer. 2006;118:797-801 pubmed
    ..The lactotransferrin gene (LTF, also referred to as the lactoferrin gene, LF) is located at 3p21...
  3. van der Strate B, Beljaars L, Molema G, Harmsen M, Meijer D. Antiviral activities of lactoferrin. Antiviral Res. 2001;52:225-39 pubmed
    b>Lactoferrin (LF) is an iron binding glycoprotein that is present in several mucosal secretions. Many biological functions have been ascribed to LF...
  4. Legrand D, Vigié K, Said E, Elass E, Masson M, Slomianny M, et al. Surface nucleolin participates in both the binding and endocytosis of lactoferrin in target cells. Eur J Biochem. 2004;271:303-17 pubmed
    b>Lactoferrin (Lf), a multifunctional molecule present in mammalian secretions and blood, plays important roles in host defense and cancer...
  5. Varadhachary A, Wolf J, Petrak K, O Malley B, Spadaro M, Curcio C, et al. Oral lactoferrin inhibits growth of established tumors and potentiates conventional chemotherapy. Int J Cancer. 2004;111:398-403 pubmed
    In this work, we investigated the anticancer activity of orally administered recombinant human lactoferrin (rhLF) alone and in combination with chemotherapy in tumor-bearing mice...
  6. Ward P, Paz E, Conneely O. Multifunctional roles of lactoferrin: a critical overview. Cell Mol Life Sci. 2005;62:2540-8 pubmed
    b>Lactoferrin (LF) is a member of the transferrin family that is expressed and secreted by glandular epithelial cells and is found in the secondary granules of neutrophils...
  7. Moreno Navarrete J, Ortega F, Bassols J, Castro A, Ricart W, Fernandez Real J. Association of circulating lactoferrin concentration and 2 nonsynonymous LTF gene polymorphisms with dyslipidemia in men depends on glucose-tolerance status. Clin Chem. 2008;54:301-9 pubmed
    ..We investigated the relationship between circulating lactoferrin, lactoferrin gene (LTF, lactotransferrin) polymorphisms, dyslipidemia, and vascular reactivity in the context of glucose-tolerance status in men...
  8. Legrand D, Pierce A, Elass E, Carpentier M, Mariller C, Mazurier J. Lactoferrin structure and functions. Adv Exp Med Biol. 2008;606:163-94 pubmed publisher
    b>Lactoferrin (Lf) is an iron binding glycoprotein of the transferrin family that is expressed in most biological fluids and is a major component of mammals' innate immune system...
  9. Zhou Y, Zeng Z, Zhang W, Xiong W, Wu M, Tan Y, et al. Lactotransferrin: a candidate tumor suppressor-Deficient expression in human nasopharyngeal carcinoma and inhibition of NPC cell proliferation by modulating the mitogen-activated protein kinase pathway. Int J Cancer. 2008;123:2065-72 pubmed publisher
    b>Lactotransferrin (LTF) has been shown to regulate tumorogenesis. However, little is known about the role of LTF in regulating the development of human nasopharyngeal carcinoma (NPC)...

More Information

Publications133 found, 100 shown here

  1. Ando K, Hasegawa K, Shindo K, Furusawa T, Fujino T, Kikugawa K, et al. Human lactoferrin activates NF-kappaB through the Toll-like receptor 4 pathway while it interferes with the lipopolysaccharide-stimulated TLR4 signaling. FEBS J. 2010;277:2051-66 pubmed publisher
    b>Lactoferrin (LF) has been implicated in innate immunity. Here we reveal the signal transduction pathway responsible for human LF (hLF)-triggered nuclear factor-kappaB (NF-kappaB) activation...
  2. Moreno Navarrete J, Serrano M, Sabater M, Ortega F, Serino M, Pueyo N, et al. Study of lactoferrin gene expression in human and mouse adipose tissue, human preadipocytes and mouse 3T3-L1 fibroblasts. Association with adipogenic and inflammatory markers. J Nutr Biochem. 2013;24:1266-75 pubmed publisher
    b>Lactoferrin is considered an epithelial protein present in different gland secretions. Administration of exogenous lactoferrin is also known to modulate adipogenesis and insulin action in human adipocytes...
  3. Deng M, Ye Q, Qin Z, Zheng Y, He W, Tang H, et al. miR-214 promotes tumorigenesis by targeting lactotransferrin in nasopharyngeal carcinoma. Tumour Biol. 2013;34:1793-800 pubmed publisher
    LTF (lactotransferrin, or lactoferrin) plays important role in innate immunity, and its anti-tumor function has also been reported in multiple cancers...
  4. Deng M, Zhang W, Tang H, Ye Q, Liao Q, Zhou Y, et al. Lactotransferrin acts as a tumor suppressor in nasopharyngeal carcinoma by repressing AKT through multiple mechanisms. Oncogene. 2013;32:4273-83 pubmed publisher
    LTF (lactotransferrin, also known as lactoferrin) is a key component of innate immune defense. It has recently been found to have anti-tumor and anti-metastatic activity in different cancers...
  5. Cardoso A, Fernandes A, Aguilar Pimentel J, de Angelis M, Guedes J, Brito M, et al. Towards frailty biomarkers: Candidates from genes and pathways regulated in aging and age-related diseases. Ageing Res Rev. 2018;47:214-277 pubmed publisher
    ..7) microparticle panel (to be further defined), GpnmB (glycoprotein nonmetastatic melanoma protein B) and lactoferrin (LTF)...
  6. Zakharova E, Sokolov A, Pavlichenko N, Kostevich V, Abdurasulova I, Chechushkov A, et al. Erythropoietin and Nrf2: key factors in the neuroprotection provided by apo-lactoferrin. Biometals. 2018;31:425-443 pubmed publisher
    Among the properties of lactoferrin (LF) are bactericidal, antianemic, immunomodulatory, antitumour, antiphlogistic effects...
  7. Wu T, Li K, Yu C, Tsai C. Tamm-Horsfall Protein is a Potent Immunomodulatory Molecule and a Disease Biomarker in the Urinary System. Molecules. 2018;23: pubmed publisher
    ..epidermal growth factor (EGF)-like domains, binds to the surface-expressed EGF-like receptors, cathepsin G, or lactoferrin to enhance polymorphonuclear leukocyte phagocytosis, proinflammatory cytokine production by monocytes/..
  8. Bazinet M, Pântea V, Cebotarescu V, Cojuhari L, Jimbei P, Albrecht J, et al. Safety and efficacy of REP 2139 and pegylated interferon alfa-2a for treatment-naive patients with chronic hepatitis B virus and hepatitis D virus co-infection (REP 301 and REP 301-LTF): a non-randomised, open-label, phase 2 trial. Lancet Gastroenterol Hepatol. 2017;2:877-889 pubmed publisher
    ..This combination therapy approach might provide a new treatment option for patients with HBV and HDV co-infection. Replicor. ..
  9. Yin S, Yang Z. An on-line database for human milk composition in China. Asia Pac J Clin Nutr. 2016;25:818-825 pubmed publisher
    ..Amino acids (~800) and proteins (alpha-lactoalbumin, beta-casein, and lactoferrin) were analyzed...
  10. Roy K, Kanwar R, Kanwar J. LNA aptamer based multi-modal, Fe3O4-saturated lactoferrin (Fe3O4-bLf) nanocarriers for triple positive (EpCAM, CD133, CD44) colon tumor targeting and NIR, MRI and CT imaging. Biomaterials. 2015;71:84-99 pubmed publisher
    This is the first ever attempt to combine anti-cancer therapeutic effects of emerging anticancer biodrug bovine lactoferrin (bLf), and multimodal imaging efficacy of Fe3O4 nanoparticles (NPs) together, as a saturated Fe3O4-bLf...
  11. Kanwar J, Kanwar R, Sun X, Punj V, Matta H, Morley S, et al. Molecular and biotechnological advances in milk proteins in relation to human health. Curr Protein Pept Sci. 2009;10:308-38 pubmed
    ..The following components of milk are of particular interest in the recent years: 1) Lactoferrin [Lf] has antibacterial, antifungal, antiviral, antiparasite and antitumor activities and accelerates ..
  12. Kautto L, Nguyen Khuong T, Everest Dass A, Leong A, Zhao Z, Willcox M, et al. Glycan involvement in the adhesion of Pseudomonas aeruginosa to tears. Exp Eye Res. 2016;145:278-288 pubmed publisher
    ..strain; 2) pre-incubation of the bacteria with N-glycans released from the commercially available human milk lactoferrin, an abundant protein that carries N-linked glycans in tears, inhibiting the adhesion to tears of the ocular ..
  13. Park E, Park S, Cho I, Kim B, Schuller Levis G. A Novel Cysteine Sulfinic Acid Decarboxylase Knock-Out Mouse: Taurine Distribution in Various Tissues With and Without Taurine Supplementation. Adv Exp Med Biol. 2017;975 Pt 1:461-474 pubmed publisher
    ..tissues from WT and HO at 2 M, expression of five taurine-related enzymes, two antioxidant enzymes as well as lactoferrin (Lft) and prolactin receptor (Prlr) was determined using RT2 qPCR...
  14. Björn C, Mahlapuu M, Mattsby Baltzer I, Håkansson J. Anti-infective efficacy of the lactoferrin-derived antimicrobial peptide HLR1r. Peptides. 2016;81:21-8 pubmed publisher
    ..Here we describe a novel AMP, HLR1r, which is structurally derived from the human milk protein lactoferrin and demonstrates a broad spectrum microbicidal action in vitro...
  15. Zhang L, de Waard M, Verheijen H, Boeren S, Hageman J, van Hooijdonk T, et al. Changes over lactation in breast milk serum proteins involved in the maturation of immune and digestive system of the infant. J Proteomics. 2016;147:40-47 pubmed publisher
    ..The decrease of the enzyme bile salt-activated lipase as well as the immunity proteins immunoglobulins and lactoferrin coincide with the gradual maturation of the digestive and immune system of infants...
  16. Li Y, Nguyen D, de Waard M, Christensen L, Zhou P, Jiang P, et al. Pasteurization Procedures for Donor Human Milk Affect Body Growth, Intestinal Structure, and Resistance against Bacterial Infections in Preterm Pigs. J Nutr. 2017;147:1121-1130 pubmed publisher
    ..both UVC-treated milk and UP showed greater activities of lipase and alkaline phosphatase and concentrations of lactoferrin, secretory immunoglobulin A, xanthine dehydrogenase, and some antioxidant markers (all P < 0.05)...
  17. Ramírez Rico G, Martínez Castillo M, de la Garza M, Shibayama M, Serrano Luna J. Acanthamoeba castellanii Proteases are Capable of Degrading Iron-Binding Proteins as a Possible Mechanism of Pathogenicity. J Eukaryot Microbiol. 2015;62:614-22 pubmed publisher
    ..Therefore, this amoeba could be in contact with different iron-binding proteins, such as lactoferrin in tears and mucosa and transferrin and hemoglobin in blood...
  18. Nishiura H, Yamanegi K, Kawabe M, Kato Kogoe N, Yamada N, Nakasho K. The roles of ribosomal protein S19 C-terminus in a shortened neutrophil lifespan through delta lactoferrin. Immunobiology. 2015;220:1085-92 pubmed publisher
    ..S19 C-terminus is bound to the C5a C-terminus, was incubated with neutrophils, and a transcription factor delta lactoferrin (δLf) was identified as a specific binding protein via pull-down experiments...
  19. Ng T, Cheung R, Wong J, Wang Y, Ip D, Wan D, et al. Antiviral activities of whey proteins. Appl Microbiol Biotechnol. 2015;99:6997-7008 pubmed publisher
    ..Chemically modified alpha-lactalbumin, beta-lactoglobulin and lysozyme, lactoferrin and lactoferricin, methylated alpha-lactalbumin, methylated and ethylated beta-lactoglobulins inhibited HSV...
  20. Thomas F, Mullen W, Tassi R, Ramírez Torres A, Mudaliar M, McNeilly T, et al. Mastitomics, the integrated omics of bovine milk in an experimental model of Streptococcus uberis mastitis: 1. High abundance proteins, acute phase proteins and peptidomics. Mol Biosyst. 2016;12:2735-47 pubmed publisher
    ..uberis caused a shift in abundance from caseins, β-lactoglobulin and α-lactalbumin to albumin, lactoferrin and IgG with the increase in lactoferrin occurring last...
  21. Shute J, Calzetta L, Cardaci V, di Toro S, Page C, Cazzola M. Inhaled nebulised unfractionated heparin improves lung function in moderate to very severe COPD: A pilot study. Pulm Pharmacol Ther. 2018;48:88-96 pubmed publisher
    ..Pre-clinical studies demonstrated that the basic proteins lactoferrin, platelet factor-4 (PF-4), IL-8 and polyarginine, as a model of the eosinophil cationic protein (ECP), found in ..
  22. Alba Palé L, León Caballero J, Samsó Buxareu B, Salgado Serrano P, Pérez Sola V. Systematic review of depression in patients with multiple sclerosis and its relationship to interferon? treatment. Mult Scler Relat Disord. 2017;17:138-143 pubmed publisher
    ..It is suggested that these patients would have fewer functional reserve remaining to deal with stressful life events, which could precipitate a depressive disorder. ..
  23. Hwang S, Kruzel M, Actor J. CHO expressed recombinant human lactoferrin as an adjuvant for BCG. Int J Immunopathol Pharmacol. 2015;28:452-68 pubmed publisher
    b>Lactoferrin (LF), an iron binding protein with immune modulatory activities, has adjuvant activity to enhance vaccine efficacy. Tuberculosis (TB) is a pulmonary disease caused by the pathogen Mycobacterium tuberculosis (MTB)...
  24. Chea C, Haing S, Miyauchi M, Shrestha M, Imanaka H, Takata T. Molecular mechanisms underlying the inhibitory effects of bovine lactoferrin on osteosarcoma. Biochem Biophys Res Commun. 2018;: pubmed publisher
    ..b>Lactoferrin (LF), a transferrin protein derived from milk, currently appears to be an anticancer agent...
  25. Soleilhavoup C, Riou C, Tsikis G, Labas V, Harichaux G, Kohnke P, et al. Proteomes of the Female Genital Tract During the Oestrous Cycle. Mol Cell Proteomics. 2016;15:93-108 pubmed publisher
    ..proteins more abundant during the luteal phase were associated with the immune system such as ceruloplasmin, lactoferrin, DMBT1, or PIGR, and also with tissue remodeling such as galectin 3 binding protein, alkaline phosphatase, CD9, ..
  26. Fardet A, Rock E. In vitro and in vivo antioxidant potential of milks, yoghurts, fermented milks and cheeses: a narrative review of evidence. Nutr Res Rev. 2017;:1-19 pubmed publisher
    ..Other antioxidants include: antioxidant enzymes; lactoferrin; conjugated linoleic acid; coenzyme Q10; vitamins C, E, A and D3; equol; uric acid; carotenoids; and mineral ..
  27. Jefferson W, Chevalier D, Phelps J, Cantor A, Padilla Banks E, Newbold R, et al. Persistently altered epigenetic marks in the mouse uterus after neonatal estrogen exposure. Mol Endocrinol. 2013;27:1666-77 pubmed publisher
    ..immunoprecipitation was used to analyze the locus-specific association of modified histones with 2 genes, lactoferrin (Ltf) and sine oculis homeobox 1 (Six1), which are permanently upregulated in adults after neonatal DES ..
  28. Jiang R, Lonnerdal B. Cloning and characterization of the human lactoferrin receptor gene promoter. Biometals. 2018;31:357-368 pubmed publisher
    b>Lactoferrin (Lf) is a major protein in human milk. Multiple biological functions of Lf are postulated to be mediated by a Lf receptor (LfR)...
  29. Ravi R, Gunjawate D, Yerraguntla K, Lewis L, Driscoll C, Rajashekhar B. Follow-up in newborn hearing screening - A systematic review. Int J Pediatr Otorhinolaryngol. 2016;90:29-36 pubmed publisher
    ..This review is a novel attempt to explore the LTF among NHS studies, reasons for LTF and strategies to reduce LTF. This review can act as a basis for planning and execution of effective NHS programs. ..
  30. Skarżyńska E, Żytyńska Daniluk J, Lisowska Myjak B. Correlations between ceruloplasmin, lactoferrin and myeloperoxidase in meconium. J Trace Elem Med Biol. 2017;43:58-62 pubmed publisher
    ..Three metal-containing proteins ceruloplasmin (CP), lactoferrin (LF) and myeloperoxidase (MPO) constitute the complementary panel modulating oxidative stress...
  31. Baroody F, Ford S, Proud D, Kagey Sobotka A, Lichtenstein L, Naclerio R. Relationship between histamine and physiological changes during the early response to nasal antigen provocation. J Appl Physiol (1985). 1999;86:659-68 pubmed
    ..b>Lactoferrin paralleled the increase in secretion weights and occurred in both nostrils...
  32. Nozaki A, Ikeda M, Naganuma A, Nakamura T, Inudoh M, Tanaka K, et al. Identification of a lactoferrin-derived peptide possessing binding activity to hepatitis C virus E2 envelope protein. J Biol Chem. 2003;278:10162-73 pubmed publisher
    ..These results led us to consider the development of an effective anti-HCV peptide. This is the first identification of a natural protein-derived peptide that specifically binds to HCV E2 protein and prevents HCV infection...
  33. Yamamoto T, Shimoyama T, Bamba T, Matsumoto K. Consecutive Monitoring of Fecal Calprotectin and Lactoferrin for the Early Diagnosis and Prediction of Pouchitis after Restorative Proctocolectomy for Ulcerative Colitis. Am J Gastroenterol. 2015;110:881-7 pubmed publisher
    ..study was conducted to evaluate the significance of consecutive monitoring of fecal calprotectin and lactoferrin for the early diagnosis and prediction of pouchitis after restorative proctocolectomy for ulcerative colitis (..
  34. Zhang L, Boeren S, Hageman J, van Hooijdonk T, Vervoort J, Hettinga K. Perspective on calf and mammary gland development through changes in the bovine milk proteome over a complete lactation. J Dairy Sci. 2015;98:5362-73 pubmed publisher
    ..The increase in immune-related proteins (immunoglobulins, osteopontin, lactoferrin) and the decrease of proteins related to milk component synthesis (α-lactalbumin, β-lactoglobulin, fatty ..
  35. Golomidova A, Kulikov E, Prokhorov N, Guerrero Ferreira R, Knirel Y, Kostryukova E, et al. Branched Lateral Tail Fiber Organization in T5-Like Bacteriophages DT57C and DT571/2 is Revealed by Genetic and Functional Analysis. Viruses. 2016;8: pubmed publisher
    ..The LTF independent adsorption was also demonstrated on an O22-like host mutant missing O-antigen O-acetylation, thus showing the biological value of this O-antigen modification for cell protection against phages. ..
  36. Marth C, Firestone S, Glenton L, Browning G, Young N, Krekeler N. Oestrous cycle-dependent equine uterine immune response to induced infectious endometritis. Vet Res. 2016;47:110 pubmed
    ..peptides equine ?-defensin 1 (EBD1), lysozyme, secretory leukoprotease inhibitor (SLPI), lipocalin 2 (LCN2), lactoferrin and uteroferrin were increased between 3 and 12 h post inoculation...
  37. Bonfatti V, Vicario D, Degano L, Lugo A, Carnier P. Comparison between direct and indirect methods for exploiting Fourier transform spectral information in estimation of breeding values for fine composition and technological properties of milk. J Dairy Sci. 2017;100:2057-2067 pubmed publisher
    ..contents of the main casein and whey protein fractions, cheese yield measured by micro-cheese making, lactoferrin, Ca, and fat composition...
  38. Anderson B, Baker H, Norris G, Rice D, Baker E. Structure of human lactoferrin: crystallographic structure analysis and refinement at 2.8 A resolution. J Mol Biol. 1989;209:711-34 pubmed
    The structure of human lactoferrin has been refined crystallographically at 2.8 A (1 A = 0.1 nm) resolution using restrained least squares methods. The starting model was derived from a 3...
  39. van Berkel P, Geerts M, van Veen H, Mericskay M, de Boer H, Nuijens J. N-terminal stretch Arg2, Arg3, Arg4 and Arg5 of human lactoferrin is essential for binding to heparin, bacterial lipopolysaccharide, human lysozyme and DNA. Biochem J. 1997;328 ( Pt 1):145-51 pubmed
    Human lactoferrin (hLF), a protein involved in host defence against infection and excessive inflammation, interacts with heparin, the lipid A moiety of bacterial lipopolysaccharide, human lysozyme (hLZ) and DNA...
  40. Singh P, Parsek M, Greenberg E, Welsh M. A component of innate immunity prevents bacterial biofilm development. Nature. 2002;417:552-5 pubmed
    ..Here we show that lactoferrin, a ubiquitous and abundant constituent of human external secretions, blocks biofilm development by the ..
  41. Trepos R, Cervin G, Pile C, Pavia H, Hellio C, Svenson J. Evaluation of cationic micropeptides derived from the innate immune system as inhibitors of marine biofouling. Biofouling. 2015;31:393-403 pubmed publisher
    ..amphiphilic cationic micropeptides, derived from the antimicrobial iron-binding innate defence protein lactoferrin, have been evaluated for their capacity to inhibit the marine fouling process...
  42. Brandenburg K, Heinbockel L, Correa W, Lohner K. Peptides with dual mode of action: Killing bacteria and preventing endotoxin-induced sepsis. Biochim Biophys Acta. 2016;1858:971-9 pubmed publisher
    ..Peptides based on natural defense proteins or polypeptides such as lactoferrin, Limulus anti-lipopolysaccharide factor (LALF), cathelicidins, and granulysins are candidates due to their high ..
  43. Neumann W, Hadley R, Nolan E. Transition metals at the host-pathogen interface: how Neisseria exploit human metalloproteins for acquiring iron and zinc. Essays Biochem. 2017;61:211-223 pubmed publisher
    ..acquire iron from the Fe(III)-transport protein transferrin (TF), the Fe(III)-chelating host-defense protein lactoferrin (LF), and the oxygen-transport protein hemoglobin (Hb), and obtain zinc from the metal-sequestering ..
  44. Hirayama M, Ko S, Kawakita T, Akiyama T, Goparaju S, Soma A, et al. Identification of transcription factors that promote the differentiation of human pluripotent stem cells into lacrimal gland epithelium-like cells. NPJ Aging Mech Dis. 2017;3:1 pubmed publisher
    ..branching morphogenesis markers such as BARX2, and lacrimal glands markers such as aquaporin5 and lactoferrin. We identified a set of transcription factors enriched in lacrimal gland epithelium cells and demonstrated that ..
  45. Nevinskii A, Soboleva S, Tuzikov F, Buneva V, Nevinsky G. DNA, oligosaccharides, and mononucleotides stimulate oligomerization of human lactoferrin. J Mol Recognit. 2009;22:330-42 pubmed publisher
    Using small-angle X-ray scattering (SAXS), light scattering (LS), and soft laser ablation we have shown that lactoferrin (LF) in solution at neutral pH is oligomerized in the absence of salt or at physiological salt concentrations...
  46. Masoodi I, Kochhar R, Dutta U, Vaishnavi C, Prasad K, Vaiphei K, et al. Fecal lactoferrin, myeloperoxidase and serum C-reactive are effective biomarkers in the assessment of disease activity and severity in patients with idiopathic ulcerative colitis. J Gastroenterol Hepatol. 2009;24:1768-74 pubmed publisher
    ..of the study was to examine the role of serum C-reactive protein (SCRP), fecal myeloperoxidase (FMPO) and fecal lactoferrin (FLF) in assessing disease severity, activity and response to therapy...
  47. Trend S, Strunk T, Lloyd M, Kok C, Metcalfe J, Geddes D, et al. Levels of innate immune factors in preterm and term mothers' breast milk during the 1st month postpartum. Br J Nutr. 2016;115:1178-93 pubmed publisher
    ..Total protein, lactoferrin, secretory IgA, soluble CD14 receptor (sCD14), transforming growth factor-β2 (TGF-β2), α defensin 5 (..
  48. Rybarczyk J, Kieckens E, Vanrompay D, Cox E. In vitro and in vivo studies on the antimicrobial effect of lactoferrin against Escherichia coli O157:H7. Vet Microbiol. 2017;202:23-28 pubmed publisher
    ..coli O157:H7 prevalence. Lactoferrin, a member of the transferrin protein family, is an iron-binding glycoprotein that is found in many exocrine ..
  49. Adam V, Zitka O, Dolezal P, Zeman L, Horna A, Hubalek J, et al. Lactoferrin Isolation Using Monolithic Column Coupled with Spectrometric or Micro-Amperometric Detector. Sensors (Basel). 2008;8:464-487 pubmed
    b>Lactoferrin is a multifunctional protein with antimicrobial activity and others tohealth beneficial properties. The main aim of this work was to propose easy to usetechnique for lactoferrin isolation from cow colostrum samples...
  50. Kruzel M, Zimecki M, Actor J. Lactoferrin in a Context of Inflammation-Induced Pathology. Front Immunol. 2017;8:1438 pubmed publisher
    Much progress has been achieved to elucidate the function of lactoferrin (LTF), an iron-binding glycoprotein, in the milieu of immune functionality...
  51. Bourne Y, Mazurier J, Legrand D, Rouge P, Montreuil J, Spik G, et al. Structures of a legume lectin complexed with the human lactotransferrin N2 fragment, and with an isolated biantennary glycopeptide: role of the fucose moiety. Structure. 1994;2:209-19 pubmed
    ..crystal structures of Lathyrus ochrus isolectin II complexed with the N2 monoglycosylated fragment of human lactotransferrin (18 kDa) and an isolated glycopeptide (2.1 kDa) fragment of human lactotransferrin (at 3.3 A and 2...
  52. Han Z, Li Q, Zhang Z, Xiao B, Gao D, Wu S, et al. High-level expression of human lactoferrin in the milk of goats by using replication-defective adenoviral vectors. Protein Expr Purif. 2007;53:225-31 pubmed
    The expression of human lactoferrin in the mammary gland is an attractive approach to diminish its current production cost...
  53. Sokolov A, Prozorovskii V, Vasilyev V. Study of interaction of ceruloplasmin, lactoferrin, and myeloperoxidase by photon correlation spectroscopy. Biochemistry (Mosc). 2009;74:1225-7 pubmed
    In this work, the diameters of protein complexes formed upon interaction of ceruloplasmin (CP) with lactoferrin (LF) and myeloperoxidase (MPO) were determined...
  54. Lee J, Jang Y, Jin B, Kim S, Kim H, Kwon B, et al. Retinoic acid enhances lactoferrin-induced IgA responses by increasing betaglycan expression. Cell Mol Immunol. 2016;13:862-870 pubmed publisher
    b>Lactoferrin (LF) and retinoic acid (RA) are enriched in colostrum, milk, and mucosal tissues...
  55. Liu E, Wang Y, He X, Guan J, Wang J, Qin Z, et al. Whole Blood PCR Amplification with Pfu DNA Polymerase and Its Application in Single-Nucleotide Polymorphism Analysis. Genet Test Mol Biomarkers. 2015;19:610-6 pubmed publisher
    ..However, human blood contains natural inhibitors of PCR such as hemoglobin, immunoglobulin G, lactoferrin, and proteases, as well as anticoagulant agents, including EDTA and heparin that can reduce whole blood PCR ..
  56. Bollimpelli V, Kumar P, Kumari S, Kondapi A. Neuroprotective effect of curcumin-loaded lactoferrin nano particles against rotenone induced neurotoxicity. Neurochem Int. 2016;95:37-45 pubmed publisher
    ..In the present study, curcumin loaded lactoferrin nano particles prepared by sol-oil chemistry were used to protect dopaminergic cell line SK-N-SH against ..
  57. Peila C, Coscia A, Bertino E, Cavaletto M, Spertino S, Icardi S, et al. Effects of Holder pasteurization on the protein profile of human milk. Ital J Pediatr. 2016;42:36 pubmed publisher
    ..and regarded the decrease of the electrophoretic bands corresponding to alpha and beta-casein, tenascin, lactoferrin and immunoglobulin...
  58. Zapata R, Singh A, Pezeshki A, Nibber T, Chelikani P. Whey Protein Components - Lactalbumin and Lactoferrin - Improve Energy Balance and Metabolism. Sci Rep. 2017;7:9917 pubmed publisher
    ..of normal protein (control) diet with high protein diets containing whey, or its fractions lactalbumin and lactoferrin, on energy balance and metabolism...
  59. Hunter H, Demcoe A, Jenssen H, Gutteberg T, Vogel H. Human lactoferricin is partially folded in aqueous solution and is better stabilized in a membrane mimetic solvent. Antimicrob Agents Chemother. 2005;49:3387-95 pubmed
    ..Here we have determined the solution structure of human lactoferricin (LfcinH) by conventional two-dimensional nuclear magnetic resonance methods in both aqueous solution and a ..
  60. Zarember K, Sugui J, Chang Y, Kwon Chung K, Gallin J. Human polymorphonuclear leukocytes inhibit Aspergillus fumigatus conidial growth by lactoferrin-mediated iron depletion. J Immunol. 2007;178:6367-73 pubmed
    ..of degranulated normal and CGD neutrophils both suppressed fungal growth and were found to be rich in lactoferrin, an abundant PMN secondary granule protein...
  61. Barker A, Duster M, Valentine S, Archbald Pannone L, Guerrant R, Safdar N. Probiotics for Clostridium difficile infection in adults (PICO): Study protocol for a double-blind, randomized controlled trial. Contemp Clin Trials. 2015;44:26-32 pubmed publisher
    ..Secondary outcomes include effect on fecal cytokines, fecal lactoferrin, and Clostridium difficile toxin density in stool, as well as patient functional status...
  62. Kawashima M, Nakamura S, Izuta Y, Inoue S, Tsubota K. Dietary Supplementation with a Combination of Lactoferrin, Fish Oil, and Enterococcus faecium WB2000 for Treating Dry Eye: A Rat Model and Human Clinical Study. Ocul Surf. 2016;14:255-63 pubmed publisher
    To examine the effect of a combined dietary supplement containing fish oil, lactoferrin, zinc, vitamin C, lutein, vitamin E, ?-aminobutanoic acid, and Enterococcus faecium WB2000 on dry eye...
  63. Puolanne A, Kolho K, Alfthan H, Ristimaki A, Mustonen H, Farkkila M. Rapid faecal tests for detecting disease activity in colonic inflammatory bowel disease. Eur J Clin Invest. 2016;46:825-32 pubmed publisher
    ..We validated two rapid tests for faecal calprotectin and one for faecal lactoferrin and compared them to the most common clinical and endoscopic scores, enzyme-linked immunosorbent assay (ELISA) ..
  64. Bonfatti V, Degano L, Menegoz A, Carnier P. Short communication: Mid-infrared spectroscopy prediction of fine milk composition and technological properties in Italian Simmental. J Dairy Sci. 2016;99:8216-8221 pubmed publisher
    ..moderate or poor accuracy for detailed protein composition, coagulation properties, curd yield and composition, lactoferrin, and concentration of major minerals...
  65. McCamphill P, Ferguson L, Sossin W. A decrease in eukaryotic elongation factor 2 phosphorylation is required for local translation of sensorin and long-term facilitation in Aplysia. J Neurochem. 2017;142:246-259 pubmed publisher
    ..These results identify decreases in eEF2 phosphorylation as a critical downstream effector of mTOR required for long-term plasticity and identify an important translational target regulated by decreases in eEF2 phosphorylation. ..
  66. Liu M, Fan F, Shi P, Tu M, Yu C, Yu C, et al. Lactoferrin promotes MC3T3-E1 osteoblast cells proliferation via MAPK signaling pathways. Int J Biol Macromol. 2018;107:137-143 pubmed publisher
    b>Lactoferrin has attracted great attention as a potential functional factor to prevent osteoporosis due to its various bioactivities. However, the molecular mechanism underlining the osteogenic activity of lactoferrin is unclear...
  67. Li K, Lu M, Hsieh S, Wu C, Yu H, Tsai C, et al. Release of surface-expressed lactoferrin from polymorphonuclear neutrophils after contact with CD4+ T cells and its modulation on Th1/Th2 cytokine production. J Leukoc Biol. 2006;80:350-8 pubmed
    ..Peptide analysis disclosed that the molecule had 99.8% identity with lactoferrin (LF). The expression of LF on system lupus erythematosis (SLE)-PMN is less than normal PMN...
  68. Alimi D, Hajaji S, Rekik M, Abidi A, Gharbi M, Akkari H. First report of the in vitro nematicidal effects of camel milk. Vet Parasitol. 2016;228:153-159 pubmed publisher
    ..Chemical composition revealed that camel milk has higher contents of protective protein (lactoferrin) and vitamin C than other species' milk...
  69. Demmelmair H, Prell C, Timby N, Lönnerdal B. Benefits of Lactoferrin, Osteopontin and Milk Fat Globule Membranes for Infants. Nutrients. 2017;9: pubmed publisher
    ..For lactoferrin, osteopontin and milk fat globule membrane proteins/lipids, which have not until recently been included in ..
  70. Meyer M, Alexander T. Reduction in necrotizing enterocolitis and improved outcomes in preterm infants following routine supplementation with Lactobacillus GG in combination with bovine lactoferrin. J Neonatal Perinatal Med. 2017;10:249-255 pubmed publisher
    ..of randomized trials has indicated a reduction in severe NEC following use of probiotics and bovine lactoferrin (LF). Overall, however, uncertainty remains over which probiotic, or combination to use...
  71. Rousseau E, Michel P, Hirsch E. The iron-binding protein lactoferrin protects vulnerable dopamine neurons from degeneration by preserving mitochondrial calcium homeostasis. Mol Pharmacol. 2013;84:888-98 pubmed publisher
    Previous studies on postmortem human brain tissue have shown that the iron-binding glycoprotein lactoferrin is upregulated in dopamine (DA) neurons resistant to degeneration in Parkinson disease (PD)...
  72. Wang B, Zhang W, Liu S, Du Z, Shan C, Qiu M. A Chinese randomized prospective trial of floppy Nissen and Toupet fundoplication for gastroesophageal disease. Int J Surg. 2015;23:35-40 pubmed publisher
    ..LTF seems to be as safe and effective on the long-term as LNF, but with a lower incidence of postoperative dysphagia (ChiCTR-TRC-13003945). ..
  73. Lopez R, Leach S, Lemberg D, Duvoisin G, Gearry R, Day A. Fecal biomarkers in inflammatory bowel disease. J Gastroenterol Hepatol. 2017;32:577-582 pubmed publisher
    ..In this review, the roles of two S100 proteins, calprotectin, and S100A12 are described along with that of lactoferrin, in the context of inflammatory bowel disease.
  74. Hwang S, Kruzel M, Actor J. Recombinant human lactoferrin modulates human PBMC derived macrophage responses to BCG and LPS. Tuberculosis (Edinb). 2016;101S:S53-S62 pubmed publisher
    b>Lactoferrin, an iron-binding glycoprotein found in mammalian mucosal secretions and granules of neutrophils, possesses several immune modulatory properties...
  75. Nicholson H, Anderson B, Bland T, Shewry S, Tweedie J, Baker E. Mutagenesis of the histidine ligand in human lactoferrin: iron binding properties and crystal structure of the histidine-253-->methionine mutant. Biochemistry. 1997;36:341-6 pubmed
    ..His 253 in the N-terminal half-molecule of human lactoferrin, LfN (residues 1-333), has been changed to Gly, Ala, Pro, Thr, Leu, Phe, Met, Tyr, Glu, Gln, and Cys by ..
  76. Qiu J, Hendrixson D, Baker E, Murphy T, St Geme J, Plaut A. Human milk lactoferrin inactivates two putative colonization factors expressed by Haemophilus influenzae. Proc Natl Acad Sci U S A. 1998;95:12641-6 pubmed
    ..Our results demonstrated that human milk lactoferrin efficiently extracted the IgA1 protease preprotein from the bacterial outer membrane...
  77. Olson E, Bohne C, Dwinell M, Podolsky A, Vidruk E, Fuller D, et al. Ventilatory long-term facilitation in unanesthetized rats. J Appl Physiol (1985). 2001;91:709-16 pubmed
    ..Ventilatory LTF appeared similar in its magnitude (after accounting for CO(2) feedback), time course, and dependence on intermittent hypoxia to phrenic LTF previously observed in anesthetized, vagotomized, paralyzed rats...
  78. Peterson N, Arcus V, Anderson B, Tweedie J, Jameson G, Baker E. "Dilysine trigger" in transferrins probed by mutagenesis of lactoferrin: crystal structures of the R210G, R210E, and R210L mutants of human lactoferrin. Biochemistry. 2002;41:14167-75 pubmed
    The mammalian iron-binding proteins lactoferrin (Lf) and transferrin (Tf) bind iron very tightly, but reversibly. Despite homologous structures and essentially identical iron binding sites, Tf begins to release iron at pH 6...
  79. Zumoffen C, Massa E, Caille A, Munuce M, Ghersevich S. Effects of lactoferrin, a protein present in the female reproductive tract, on parameters of human sperm capacitation and gamete interaction. Andrology. 2015;3:1068-75 pubmed publisher
    In a recent study, lactoferrin (LF) was detected in human oviductal secretion. The protein was able to bind to oocytes and sperm, and modulated gamete interaction...
  80. Langhorst J, Boone J, Lauche R, Rueffer A, Dobos G. Faecal Lactoferrin, Calprotectin, PMN-elastase, CRP, and White Blood Cell Count as Indicators for Mucosal Healing and Clinical Course of Disease in Patients with Mild to Moderate Ulcerative Colitis: Post Hoc Analysis of a Prospective Clinical Trial. J Crohns Colitis. 2016;10:786-94 pubmed publisher
    ..Clinical Activity Index [CAI], faecal lactoferrin [FLA], calprotectin [CAL], PMN-elastase [PMN-e], C-reactive protein [CRP], white blood cells [WBC], Endoscopic ..
  81. Manzoni P. Clinical Benefits of Lactoferrin for Infants and Children. J Pediatr. 2016;173 Suppl:S43-52 pubmed publisher
    To discuss the potential clinical benefits of lactoferrin in preterm and term infants, as well as in young children and to review information on the burden of neonatal sepsis...
  82. Khuyen T, Mandiki S, Cornet V, Douxfils J, Betoulle S, Bossier P, et al. Physiological and immune response of juvenile rainbow trout to dietary bovine lactoferrin. Fish Shellfish Immunol. 2017;71:359-371 pubmed publisher
    b>Lactoferrin, a large multifunctional glycoprotein, is involved in many physiological functions but its immunomodulatory pathways are not well characterized in fish...
  83. Ellison R, Giehl T, LaForce F. Damage of the outer membrane of enteric gram-negative bacteria by lactoferrin and transferrin. Infect Immun. 1988;56:2774-81 pubmed
    Many studies have shown that lactoferrin and transferrin have antimicrobial activity against gram-negative bacteria, but a mechanism of action has not been defined...
  84. Faber H, Bland T, Day C, Norris G, Tweedie J, Baker E. Altered domain closure and iron binding in transferrins: the crystal structure of the Asp60Ser mutant of the amino-terminal half-molecule of human lactoferrin. J Mol Biol. 1996;256:352-63 pubmed
    The crystal structure of a site-specific mutant of the N-terminal half-molecule of human lactoferrin, Lf(N), in which the iron ligand Asp60 has been mutated to Ser, has been determined at 2...
  85. van Berkel P, van Veen H, Geerts M, de Boer H, Nuijens J. Heterogeneity in utilization of N-glycosylation sites Asn624 and Asn138 in human lactoferrin: a study with glycosylation-site mutants. Biochem J. 1996;319 ( Pt 1):117-22 pubmed
    Human lactoferrin (hLF) is a glycoprotein involved in the host defence against infection and excessive inflammation...
  86. Barman S, Gebber G, Orer H. Medullary lateral tegmental field: an important source of basal sympathetic nerve discharge in the cat. Am J Physiol Regul Integr Comp Physiol. 2000;278:R995-R1004 pubmed
    ..These data indicate that EAA-mediated synaptic drive to RVLM-spinal sympathoexcitatory neurons accounts for a significant component of their basal activity...
  87. Peterson N, Anderson B, Jameson G, Tweedie J, Baker E. Crystal structure and iron-binding properties of the R210K mutant of the N-lobe of human lactoferrin: implications for iron release from transferrins. Biochemistry. 2000;39:6625-33 pubmed
    b>Lactoferrin (Lf) and serum transferrin (Tf) combine high-affinity iron binding with an ability to release this iron at reduced pH...
  88. Lupetti A, Paulusma Annema A, Welling M, Senesi S, Van Dissel J, Nibbering P. Candidacidal activities of human lactoferrin peptides derived from the N terminus. Antimicrob Agents Chemother. 2000;44:3257-63 pubmed
    In light of the need for new antifungal agents, the candidacidal activities of human lactoferrin (hLF) and synthetic peptides representing the first, hLF(1-11), and second, hLF(21-31), cationic domains of its N terminus were compared...
  89. Barman S, Orer H, Gebber G. Differential effects of an NMDA and a non-NMDA receptor antagonist on medullary lateral tegmental field neurons. Am J Physiol Regul Integr Comp Physiol. 2002;282:R100-13 pubmed
    ..001, n = 10). These data support the view that non-NMDA and NMDA receptors are involved in setting the basal level of activity of LTF sympathoexcitatory neurons and in synchronizing their discharges to the AP, respectively...
  90. Pulina M, Zakharova E, Sokolov A, Shavlovski M, Bass M, Solovyov K, et al. Studies of the ceruloplasmin-lactoferrin complex. Biochem Cell Biol. 2002;80:35-9 pubmed
    We have previously shown that iron-containing human lactoferrin (LF) purified from breast milk is able to form both in vitro and in vivo a complex with ceruloplasmin (CP), the copper-containing protein of human plasma...
  91. Liu D, Wang X, Zhang Z, Teng C. An intronic alternative promoter of the human lactoferrin gene is activated by Ets. Biochem Biophys Res Commun. 2003;301:472-9 pubmed
    b>Lactoferrin expresses in a variety of tissues and involves in various aspects of host defense mechanisms. The lactoferrin gene is differentially regulated through multiple signaling pathways...
  92. Sakamoto K, Ito Y, Mori T, Sugimura K. Interaction of human lactoferrin with cell adhesion molecules through RGD motif elucidated by lactoferrin-binding epitopes. J Biol Chem. 2006;281:24472-8 pubmed
    b>Lactoferrin (LF) is an iron-binding secretory protein, which is distributed in the secondary granules of polynuclear lymphocytes as well as in the milk produced by female mammals...