lactoferrin

Summary

Gene Symbol: lactoferrin
Description: lactotransferrin
Alias: GIG12, HLF2, growth-inhibiting protein 12, neutrophil lactoferrin, talalactoferrin
Species: human

Top Publications

  1. ncbi Complete nucleotide sequence of human mammary gland lactoferrin
    M W Rey
    Genencor International, South San Francisco, CA 94080
    Nucleic Acids Res 18:5288. 1990
  2. ncbi Efficacy of a lactoferrin-penicillin combination to treat {beta}-lactam-resistant Staphylococcus aureus mastitis
    D Petitclerc
    Crea Biopharma Inc, Sherbrooke, Quebec, Canada J1E 4K8
    J Dairy Sci 90:2778-87. 2007
  3. ncbi Human delta-lactoferrin is a transcription factor that enhances Skp1 (S-phase kinase-associated protein) gene expression
    Christophe Mariller
    Unite de Glycobiologie Structurale et Fonctionnelle, Unité Mixte de Recherche 8576 CNRS Université des Sciences et Technologies de Lille1, Villeneuve d Ascq, France
    FEBS J 274:2038-53. 2007
  4. ncbi Serum lactoferrin and immunoglobulin G concentrations in healthy or ill neonatal foals and healthy adult horses
    Michelle Henry Barton
    Department of Large Animal Medicine, College of Veterinary Medicine, The University of Georgia, Athens, GA, USA
    J Vet Intern Med 20:1457-62. 2006
  5. ncbi Down regulation of 3p genes, LTF, SLC38A3 and DRR1, upon growth of human chromosome 3-mouse fibrosarcoma hybrids in severe combined immunodeficiency mice
    Irina D Kholodnyuk
    Microbiology and Tumour Biology Center, Karolinska Institute, Stockholm, Sweden
    Int J Cancer 119:99-107. 2006
  6. ncbi Genetic and epigenetic inactivation of LTF gene at 3p21.3 in lung cancers
    Hironobu Iijima
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Maebashi, Gunma 371 8511, Japan
    Int J Cancer 118:797-801. 2006
  7. ncbi Genetic and epigenetic alterations of LTF at 3p21.3 in nasopharyngeal carcinoma
    Hong Mei Yi
    Cancer Research Institute, Xiang Ya School of Medicine, Central South University, Changsha, Hunan, P R China
    Oncol Res 16:261-72. 2006
  8. ncbi Identification of an import signal for, and the nuclear localization of, human lactoferrin
    S Penco
    Department of Oncology, Biology and Genetics, University of Genoa, Viale Benedetto XV, 6 Genoa, Italy
    Biotechnol Appl Biochem 34:151-9. 2001
  9. ncbi Multifunctional roles of lactoferrin: a critical overview
    P P Ward
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Cell Mol Life Sci 62:2540-8. 2005
  10. ncbi Bovine whey fractionation based on cation-exchange chromatography
    R Hahn
    Institute of Applied Microbiology, University of Agriculture, Forestry and Biotechnology, Vienna, Austria
    J Chromatogr A 795:277-87. 1998

Research Grants

  1. HEMIN UTILIZATION BY P GINGIVALIS
    Caroline Genco; Fiscal Year: 1999
  2. Recombinant Lactoferrin and Necrotizing Enterocolitis
    Karel Petrak; Fiscal Year: 2004
  3. IRON ACQUISITION IN BORDETELLA PERTUSSIS
    SANDRA KAY ARMSTRONG; Fiscal Year: 2010
  4. REGULATION OF GRANULOCYTE SECRETION
    Laurence Boxer; Fiscal Year: 1993
  5. Structure/function studies of lactoferrin as a protease
    Andrew Plaut; Fiscal Year: 2005
  6. A TRANSCRIPTIONAL PROGRAM REGULATING MYELOPOIESIS
    Alan Friedman; Fiscal Year: 2004
  7. CDP/CUT AND MYELOID DIFFERENTIATION
    Nancy Berliner; Fiscal Year: 2001
  8. PspA: A Potential Pneumococcal Vaccine Component
    David E Briles; Fiscal Year: 2010
  9. Iron acquisition mechanisms utilized by Neisseria gonorrhoeae
    Cynthia Nau Cornelissen; Fiscal Year: 2010
  10. PspA: A Potential Pneumococcal Vaccine Component
    David Briles; Fiscal Year: 2009

Detail Information

Publications199 found, 100 shown here

  1. ncbi Complete nucleotide sequence of human mammary gland lactoferrin
    M W Rey
    Genencor International, South San Francisco, CA 94080
    Nucleic Acids Res 18:5288. 1990
  2. ncbi Efficacy of a lactoferrin-penicillin combination to treat {beta}-lactam-resistant Staphylococcus aureus mastitis
    D Petitclerc
    Crea Biopharma Inc, Sherbrooke, Quebec, Canada J1E 4K8
    J Dairy Sci 90:2778-87. 2007
    ..The efficacy of intramammary (IM) treatments containing penicillin G (PG) alone or a combination of PG and bovine lactoferrin (bLF) was evaluated using a model of experimentally induced chronic bovine mastitis caused by a clinical ..
  3. ncbi Human delta-lactoferrin is a transcription factor that enhances Skp1 (S-phase kinase-associated protein) gene expression
    Christophe Mariller
    Unite de Glycobiologie Structurale et Fonctionnelle, Unité Mixte de Recherche 8576 CNRS Université des Sciences et Technologies de Lille1, Villeneuve d Ascq, France
    FEBS J 274:2038-53. 2007
    Delta-lactoferrin is a cytoplasmic lactoferrin isoform that can locate to the nucleus, provoking antiproliferative effects and cell cycle arrest in S phase...
  4. ncbi Serum lactoferrin and immunoglobulin G concentrations in healthy or ill neonatal foals and healthy adult horses
    Michelle Henry Barton
    Department of Large Animal Medicine, College of Veterinary Medicine, The University of Georgia, Athens, GA, USA
    J Vet Intern Med 20:1457-62. 2006
    b>Lactoferrin is a colostral glycoprotein with antimicrobial properties.
  5. ncbi Down regulation of 3p genes, LTF, SLC38A3 and DRR1, upon growth of human chromosome 3-mouse fibrosarcoma hybrids in severe combined immunodeficiency mice
    Irina D Kholodnyuk
    Microbiology and Tumour Biology Center, Karolinska Institute, Stockholm, Sweden
    Int J Cancer 119:99-107. 2006
    ..Our data indicate these genes as putative tumour suppressor genes...
  6. ncbi Genetic and epigenetic inactivation of LTF gene at 3p21.3 in lung cancers
    Hironobu Iijima
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Maebashi, Gunma 371 8511, Japan
    Int J Cancer 118:797-801. 2006
    ..The lactotransferrin gene (LTF, also referred to as the lactoferrin gene, LF) is located at 3p21...
  7. ncbi Genetic and epigenetic alterations of LTF at 3p21.3 in nasopharyngeal carcinoma
    Hong Mei Yi
    Cancer Research Institute, Xiang Ya School of Medicine, Central South University, Changsha, Hunan, P R China
    Oncol Res 16:261-72. 2006
    To investigate the roles of lactotransferrin gene (LTF, also referred to as the lactoferrin gene, LF), located at 3p21...
  8. ncbi Identification of an import signal for, and the nuclear localization of, human lactoferrin
    S Penco
    Department of Oncology, Biology and Genetics, University of Genoa, Viale Benedetto XV, 6 Genoa, Italy
    Biotechnol Appl Biochem 34:151-9. 2001
    Many different unique functions have been attributed to lactoferrin (Lf), including DNA and RNA binding, and transport into the nucleus, where Lf binds to specific sequences and activates transcription...
  9. ncbi Multifunctional roles of lactoferrin: a critical overview
    P P Ward
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Cell Mol Life Sci 62:2540-8. 2005
    b>Lactoferrin (LF) is a member of the transferrin family that is expressed and secreted by glandular epithelial cells and is found in the secondary granules of neutrophils...
  10. ncbi Bovine whey fractionation based on cation-exchange chromatography
    R Hahn
    Institute of Applied Microbiology, University of Agriculture, Forestry and Biotechnology, Vienna, Austria
    J Chromatogr A 795:277-87. 1998
    ..A fractionation scheme for the economically interesting proteins, such as IgG, lactoferrin and lactoperoxidase, based on cation exchangers was the goal of our investigations...
  11. ncbi Metal storage and transport proteins increase after exposure of the rat lung to an air pollution particle
    A J Ghio
    National Health and Environmental Effects Research Laboratory, Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Toxicol Pathol 26:388-94. 1998
    ..We tested the hypothesis that the concentrations of both lactoferrin and ferritin in the rat lung increase after exposure to a metal-rich emission source air pollution particle...
  12. ncbi [Disturbed neutrophil activation in pneumonia during medicinal immunosuppression]
    J Braun
    Medizinische Klinik II,
    Pneumologie 51:1037-42. 1997
    ..cell differential the BALF concentrations of the neutrophil degranulation products myeloperoxidase (MPO) and lactoferrin were determined using immunoluminometric assays...
  13. ncbi Abnormal cell differentiation and p21 expression of endometrial epithelial cells following developmental exposure to diethylstilbestrol (DES)
    A Yoshida
    Laboratory of Experimental Pathology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Toxicol Pathol 28:237-45. 2000
    ..These cells also showed increased expression of lactoferrin, a sensitive protein marker of estrogen exposure, although the staining intensity decreased after exposure ..
  14. ncbi Subcellular distribution of urokinase and urokinase receptor in human neutrophils determined by immunoelectron microscopy
    T L Pedersen
    Department of Pathology, Herlev Hospital, University of Copenhagen, Denmark
    Ultrastruct Pathol 24:175-82. 2000
    ..markers for well-defined subtypes of granules: matrix metalloproteinase type-9 (MMP-9) for gelatinase granules, lactoferrin (LF) for specific granules, and myeloperoxidase (MPO) and neutrophil elastase (NE) for primary granules...
  15. ncbi Immunohistochemical study of ceruloplasmin, lactoferrin and secretory component expression in neoplastic and non-neoplastic thyroid gland diseases
    A Kondi-Pafiti
    Department of Pathology, Athens University, School of Medicine, Areteion Hospital, Greece
    Acta Oncol 39:753-6. 2000
    The expression of lactoferrin (LF), ceruloplasmin (CP) and secretory component (SC) in various thyroid diseases was investigated using an immunohistochemical method...
  16. ncbi Towards a closed eye model of the pre-ocular tear layer
    R A Sack
    SUNY, College of Optometry, 100 East 20 Street, Manhattan, NY 10010, USA
    Prog Retin Eye Res 19:649-68. 2000
    ..an inducible, neurologically controlled, lacrimal secretion containing among other proteins primarily lysozyme, lactoferrin and tear specific lipocalin, to a much slower, constitutive-type of secretion, composed almost exclusively of ..
  17. ncbi [Reverting effect of cysteine on the suppression by glucose or dexamethasone of anti-Candida activity of human neutrophils]
    T Tansho
    Department of Surgery II, Teikyo University School of Medicine
    Kansenshogaku Zasshi 72:727-37. 1998
    ..Correspondingly, cysteine augmented production of lactoferrin by stimulated neutrophils; which functions as a major effector molecule in growth inhibition of Candida by ..
  18. ncbi [Myeloperoxidase, lactoferrin and elastase in bronchoalveolar lavage and plasma in pneumonia]
    J Braun
    ,
    Pneumologie 46:141-7. 1992
    ..BALF) and in plasma, the concentration of the locally produced granulocyte products myeloperoxidase (MPO), lactoferrin (LF) and elastase-alpha 1 proteinase complex (ELA) as well as of the alpha 1 proteinase inhibitor (alpha 1 Pi) ..
  19. ncbi Thin-layer ion-exchange chromatography of proteins
    Q Luo
    Department of Materials Science and Engineering, University of Utah, Salt Lake City 84112-0560, USA
    J Chromatogr A 816:97-105. 1998
    ..The net charges were calculated for four model proteins, albumin, transferrin, lactoferrin and lysozyme, under different pH values...
  20. ncbi Two ion-exchange chromatographic methods for the isolation of antibacterial peptides from lactoferrin. In situ enzymatic hydrolysis on an ion-exchange membrane
    I Recio
    Department of Product Technology, NIZO Food Research, Ede, The Netherlands
    J Chromatogr A 831:191-201. 1999
    Two ion-exchange chromatographic methods are reported for the rapid isolation of antibacterial peptides from lactoferrin (LF)...
  21. ncbi A rapid and efficient physiologic chemical method of labeling plasma proteins with indium-111
    D W Wong
    Department of Radiology, King Drew Medical Center U C L A 90059
    Int J Rad Appl Instrum A 38:1067-72. 1987
    ..Human serum albumin, IgG, fibrinogen, transferrin, lactoferrin and the enzyme bovine thrombin had been successfully labeled with exceptionally high labeling yields of greater ..
  22. ncbi Determination of the minor whey protein bovine lactoferrin in cheese whey concentrates with capillary electrophoresis
    P Riechel
    , , Germany
    J Chromatogr A 817:187-93. 1998
    In our present work we present the determination of bovine lactoferrin in whey concentrates as they are typically produced by milk and cheese industry after production of cheese...
  23. ncbi [Bacteriostatic activity of bovine colostrum]
    H Ushijima
    Department of Enteroviruses, National Institute of Health
    Kansenshogaku Zasshi 65:54-60. 1991
    ..of non immunized bovine colostrum immunoglobulin, we studied the bacteriostatic activity of the immunoglobulin, lactoferrin and lactoferrin Fe by using the automated antimicrobial susceptibility testing system...
  24. ncbi Differential spatiotemporal regulation of lactoferrin and progesterone receptor genes in the mouse uterus by primary estrogen, catechol estrogen, and xenoestrogen
    S K Das
    Department of Molecular and Integrative Physiology, University of Kansas Medical Center, Ralph L Smith Research Center, Kansas City 66160 7338, USA
    Endocrinology 139:2905-15. 1998
    ..E2) and 4-hydroxyestradiol-17beta (4-OH-E2), a catechol metabolite of E2, on uterine expression of lactoferrin (LF) and progesterone receptor (PR). These genes are estrogen responsive in the mouse uterus...
  25. ncbi Oral lactoferrin for the prevention of sepsis and necrotizing enterocolitis in preterm infants
    Mohan P Venkatesh
    Pediatrics, Section of Neonatology, Baylor College of Medicine, 6621, Fannin, MC WT 6 104, Houston, Texas, USA, 77030
    Cochrane Database Syst Rev 5:CD007137. 2010
    BACKGROUND: Lactoferrin, a normal component of human colostrum, milk, tears and saliva can enhance host defence and may be effective in the prevention of sepsis and necrotizing enterocolitis (NEC) in preterm neonates...
  26. ncbi Host iron binding proteins acting as niche indicators for Neisseria meningitidis
    Philip W Jordan
    The Bacterial Pathogenesis and Functional Genomics Group, The Sir William Dunn School of Pathology, University of Oxford, Oxford, United Kingdom
    PLoS ONE 4:e5198. 2009
    ..available iron sources differ, particularly the host iron-binding proteins haemoglobin, transferrin, and lactoferrin. This study compared the transcriptional responses of N...
  27. ncbi Effects of colostrum replacer supplemented with lactoferrin on the blood plasma immunoglobulin G concentration and intestinal absorption of xylose in the neonatal calf
    E C Shea
    Department of Animal and Nutritional Sciences, University of New Hampshire, Durham 03824, USA
    J Anim Sci 87:2047-54. 2009
    The objective of this experiment was to determine the effect of lactoferrin (Lf) supplementation of colostrum replacer (CR) fed as 1 or 2 doses on apparent efficiency of IgG absorption, serum IgG concentrations, and xylose absorption/..
  28. ncbi Binding of extracellular matrix proteins by animal strains of staphylococcal species
    I Styriak
    Department of Microbiology, Institute of Animal Physiology, Slovak Academy of Sciences, Kosice, Slovakia
    Vet Microbiol 67:99-112. 1999
    ..Bovine lactoferrin, human vitronectin, human fibronectin, heparin, human and bovine serum albumin were immobilized on latex beads ..
  29. ncbi Lactoferrin expression in the canine uterus during the estrous cycle and with pyometra
    K Kida
    Department of Advanced Pathobiology, Graduate School of Life and Environmental Sciences, Osaka Prefecture University, Osaka 599 8531, Japan
    Theriogenology 66:1325-33. 2006
    The expression of lactoferrin, a non-specific antimicrobial defence, in the canine uterus during the normal estrous cycle and in bitches with pyometra was examined...
  30. ncbi A new chance of preventing winter diseases by the administration of synbiotic formulations
    Fabrizio Pregliasco
    Department of Public Health Microbiology Virology, Universita degli Studi di Milano, Milan, Italy Fabrizio
    J Clin Gastroenterol 42:S224-33. 2008
    ..containing 3 to 5 strains of Lactobacillus plantarum, Lactobacillus rhamnosus, and Bifidobacterium lactis, lactoferrin and prebiotics such as either FOS (short-chain fructooligosaccharides) or GOS (galactooligosaccharides)...
  31. ncbi Lactoferrin-enhanced anoikis: a defense against neonatal necrotizing enterocolitis
    Michael P Sherman
    Division of Neonatology, School of Medicine, University of California, Surge I, Suite 1121, Davis, CA 95616, USA
    Med Hypotheses 65:478-82. 2005
    Enteral nutrition with human milk lowers the incidence of necrotizing enterocolitis in preterm human infants. Lactoferrin, the major whey protein in human milk, has many functions related to host defense against bacterial infection...
  32. ncbi Use and endocytosis of iron-containing proteins by Entamoeba histolytica trophozoites
    Fernando López-Soto
    Departamento de Biologia Celular, Centro de Investigacion y de Estudios Avanzados del IPN, Mexico, DF 07000, Mexico
    Infect Genet Evol 9:1038-50. 2009
    ..all organisms; in mammals, it is part of proteins such as haemoglobin, and it is captured by transferrin and lactoferrin. Transferrin is present in serum, and lactoferrin is secreted by the mucosa and by neutrophils at infection ..
  33. ncbi Diarrhea, clostridium difficile, and intestinal inflammation in residents of a long-term care facility
    Laurie Archbald-Pannone
    University of Virginia, Department of Internal Medicine, Division of General Medicine, Section of Geriatrics, Charlottesville, VA 22908, USA
    J Am Med Dir Assoc 11:263-7. 2010
    ....
  34. ncbi Utilization of lactoferrin to fight antibiotic-resistant mammary gland pathogens
    P Lacasse
    Agriculture and Agri Food Canada, Dairy and Swine Research and Development Centre, PO Box 90 STN Lennoxville, Sherbrooke, Quebec, Canada J1M 1Z3
    J Anim Sci 86:66-71. 2008
    ..b>Lactoferrin (Lf) is naturally produced by the mammary gland...
  35. ncbi Characterization of lactoferrin receptor on human spermatozoa
    Peng Wang
    Laboratory of Reproductive Medicine, Department of Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China
    Reprod Biomed Online 22:155-61. 2011
    b>Lactoferrin (LF) is abundant in human seminal plasma and on sperm surfaces. However, lactoferrin receptor (LFR) on human spermatozoa has not yet been reported...
  36. ncbi Characterization of the infection-responsive bovine lactoferrin promoter
    Jiamao Zheng
    Lactation and Mammary Gland Biology Group, Department of Animal Science, 213 Terrill Hall, University of Vermont, Burlington, VT 05405, USA
    Gene 353:107-17. 2005
    The concentration of lactoferrin in bovine milk is dramatically increased in response to infection. The high levels of lactoferrin may have a role in the prevention of microbial infection of the mammary gland...
  37. ncbi [The role of lactoferrin in the iron metabolism. Part II. Antimicrobial and antiinflammatory effect of lactoferrin by chelation of iron]
    Jolanta Artym
    Zakład Terapii Doświadczalnej Instytutu Immunologii i Terapii Doświadczalnej PAN im L Hirszfelda we Wrocławiu, 53 114 Wrocław
    Postepy Hig Med Dosw (Online) 64:604-16. 2010
    b>Lactoferrin (LF) is a glycoprotein widely distributed in mammalian organisms. It is synthesized by epithelial cells; hence it is present in secretions of mucous membranes...
  38. ncbi Coadsorption of human milk lactoferrin into the dipalmitoylglycerolphosphatidylcholine phospholipid monolayer spread at the air/water interface
    Fausto Miano
    Società Industria Farmaceutica Italiana SpA, Lavinaio Catania, Italy
    Biophys J 92:1254-62. 2007
    The coadsorption of human milk lactoferrin into a spread monolayer of dipalmitoylglycerol phosphatidylcholine (DPPC) at the air/water interface has been studied by neutron reflection...
  39. ncbi Rapid purification of porcine colostral whey lactoferrin by affinity chromatography on single-stranded DNA-agarose. Characterization, amino acid composition and N-terminal amino acid sequence
    T W Hutchens
    USDA ARS Children s Nutrition Research Center, Department of Pediatries, Baylor College of Medicine, Houston 77030
    Biochim Biophys Acta 999:323-9. 1989
    We have determined that the major iron-binding and DNA-binding protein in porcine colostral whey is lactoferrin. This lactoferrin was purified to homogeneity in one chromatographic step using immobilized single-stranded DNA-agarose...
  40. ncbi Elevated free tear lactoferrin levels in leprosy are associated with Type 2 reactions
    Ebenezer Daniel
    Department of Ophthalmology, Schieffelin Leprosy Research and Training Center, Tamil Nadu, India
    Indian J Ophthalmol 52:51-6. 2004
    To determine the association of demographics, leprosy and ocular characteristics with altered levels of lactoferrin in the tears of normal subjects and leprosy patients, and to detect the presence of antibodies to lactoferrin in these ..
  41. ncbi The low-density lipoprotein receptor-related protein 1 is a mitogenic receptor for lactoferrin in osteoblastic cells
    Andrew Grey
    Department of Medicine, University of Auckland, Private Bag 92019, Auckland, New Zealand
    Mol Endocrinol 18:2268-78. 2004
    b>Lactoferrin induces osteoblast proliferation and survival in vitro and is anabolic to bone in vivo...
  42. ncbi Bovine lactoferrin supplementation for prevention of late-onset sepsis in very low-birth-weight neonates: a randomized trial
    Paolo Manzoni
    Neonatology and Neonatal Intensive Care Unit, S Anna Hospital, Azienda Ospedaliera Regina Margherita S Anna, C Spezia 60, 10126 Torino, Italy
    JAMA 302:1421-8. 2009
    ..Whether lactoferrin, a mammalian milk glycoprotein involved in innate immune host defenses, can reduce the incidence of sepsis is ..
  43. ncbi Bovine lactoferrin inhibits Japanese encephalitis virus by binding to heparan sulfate and receptor for low density lipoprotein
    Yu Jung Chien
    Graduate Institute of Veterinary Public Health, College of Veterinary Medicine, National Chung Hsing University, Taichung, Taiwan
    Virology 379:143-51. 2008
    b>Lactoferrin is a natural anti-microbial protein which affects Japanese encephalitis virus (JEV) activity...
  44. ncbi A curcumin-based 1-week triple therapy for eradication of Helicobacter pylori infection: something to learn from failure?
    Francesco Di Mario
    Section of Gastroenterology, Department of Clinical Sciences, University of Parma, Italy
    Helicobacter 12:238-43. 2007
    ..N-acetylcysteine and lactoferrin with their respective mucolytic and antibacterial activities might also be effective in H...
  45. ncbi Anti-neutrophil cytoplasmic antibodies in patients with chronic liver diseases: prevalence, antigen specificity and predictive value for diagnosis of autoimmune liver disease. Swedish Internal Medicine Liver Club (SILK)
    S Lindgren
    Department of Medicine, University Hospital, Malmo, Sweden
    J Gastroenterol Hepatol 15:437-42. 2000
    ..As their predictive value for autoimmune liver disease remains unknown, we analysed the prevalence and antigen specificity of ANCA in patients with various chronic liver diseases (CLD)...
  46. ncbi Noninvasive markers in the assessment of intestinal inflammation in inflammatory bowel diseases: performance of fecal lactoferrin, calprotectin, and PMN-elastase, CRP, and clinical indices
    Jost Langhorst
    Department of Internal and Integrative Medicine, Kliniken Essen Mitte, University of Duisburg Essen, Germany
    Am J Gastroenterol 103:162-9. 2008
    The aim of this study was to compare the performance of fecal lactoferrin (Lf), calprotectin (Cal), polymorphonuclear neutrophil elastase (PMN-e), as well as serum C-reactive protein (CRP) in patients with inflammatory bowel diseases (..
  47. ncbi Short communication: Antimicrobial effect of lactoferrin and its amidated and pepsin-digested derivatives against Salmonella Enteritidis and Pseudomonas fluorescens
    A del Olmo
    Departamento de Tecnologia de Alimentos, INIA, Carretera de la Coruña Km 7, Madrid, 28040 Spain
    J Dairy Sci 93:3965-9. 2010
    The antimicrobial effect of bovine lactoferrin (LF) and its amidated and pepsin-digested derivatives, at concentrations varying from 0...
  48. ncbi Variation in antimicrobial activity of lactoferricin-derived peptides explained by structure modelling
    Sebastien Farnaud
    Randall Division of Cell and Molecular Biophysics, King s College London, New Hunt s House, Guy s Campus, St Thomas Street, London SE1 1UL, UK
    FEMS Microbiol Lett 238:221-6. 2004
    ..peptides bovine lactoferricin (LfcinB) and human lactoferricin (LfcinH) are produced from the respective lactoferrin, but are more active than their precursors...
  49. ncbi Activated lactoferrin and fluconazole synergism against Candida albicans and Candida glabrata vaginal isolates
    A Satyanarayan Naidu
    N terminus Research Laboratory, Pomona, CA 91768, USA
    J Reprod Med 49:800-7. 2004
    To evaluate the fungistatic activity of activated lactoferrin (ALF), fluconazole (FCN) individually and in combination against Candida vaginal isolates as well as to measure the time to recovery from the fungistatic effects after ..
  50. ncbi Glycosaminoglycans are not indispensable for the anti-herpes simplex virus type 2 activity of lactoferrin
    M Marchetti
    Department of Technology and Health, Istituto Superiore di Sanita, Viale Regina Elena 299, 00161 Rome, Italy
    Biochimie 91:155-9. 2009
    b>Lactoferrin has been recognized as a potent inhibitor of human herpetic viruses, such as herpes simplex type 1 (HSV-1) and 2 (HSV-2)...
  51. ncbi Recognition of lactoferrin and aminopeptidase M-modified lactoferrin by the liver: involvement of proteoglycans and the remnant receptor
    G J Ziere
    Division of Biopharmaceutics, Leiden Amsterdam Center for Drug Research, University of Leiden, Sylvius Laboratory, The Netherlands
    Biochem J 313:289-95. 1996
    1. Lactoferrin and aminopeptidase M-modified lactoferrin (APM-lactoferrin; which lacks its 14 N-terminal amino acids) inhibit the liver uptake of lipoprotein remnant...
  52. ncbi Biochemical analysis of lactoferrin receptors in the Neisseriaceae: identification of a second bacterial lactoferrin receptor protein
    R A Bonnah
    Department of Microbiology and Infectious Diseases, University of Calgary, Alberta, Canada
    Microb Pathog 19:285-97. 1995
    ..In contrast, bacterial lactoferrin receptors have only been described for human pathogens in the family Neisseriaceae, and were believed to ..
  53. ncbi [Muramidase and lactoferrin in adenoidal hypertrophies, hypertrophic and chronic infected tonsil tissue--a quantitative analysis]
    M Schwaab
    Universitätsklinik für Hals Nasen Ohrenheilkunde und Kopf und Halschirurgie, Ruhr Universitat Bochum
    Laryngorhinootologie 84:660-4. 2005
    Muramidase and lactoferrin are important components of the antimicrobial defense system. Muramidase has the ability of opsonization and immunopotentiation and therefore a close relation to the lymphatic tissue...
  54. ncbi Effect of dietary lactoferrin on the immune functions and serum iron level of weanling piglets
    T Shan
    Institute of Feed Science, Zhejiang University, The Key Laboratory of Molecular Animal Nutrition, Ministry of Education, No 164 Qiutao North Road, Hangzhou 310029, PR China
    J Anim Sci 85:2140-6. 2007
    ..female pigs (Duroc x Landrace x Yorkshire) were used in a 30-d growth experiment to investigate the effect of lactoferrin (LF) on growth performance, immune function, and serum iron concentrations...
  55. ncbi Lactoferrin given in food facilitates dermatophytosis cure in guinea pig models
    H Wakabayashi
    Nutritional Science Laboratory, Morinaga Milk Industry Co Ltd, Zama, Kanagawa 228 8583, Japan
    J Antimicrob Chemother 46:595-602. 2000
    ..We studied the in vitro and in vivo antifungal effects of lactoferrin against Trichophyton...
  56. ncbi Effect of lactoferrin on Helicobacter felis induced gastritis
    Elizabeth J Dial
    Department of Integrative Biology and Pharmacology, University of Texas Health Science Center, Houston Medical School, 77225, USA
    Biochem Cell Biol 80:113-7. 2002
    b>Lactoferrin possesses antibiotic, antiinflammatory, and immune-modulating properties that may be active against the gastritis-, ulcer- and cancer-inducing bacterium Helicobacter pylori...
  57. ncbi Lactoferrin sequestration and its contribution to iron-deficiency anemia in Helicobacter pylori-infected gastric mucosa
    Yon Ho Choe
    Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
    J Gastroenterol Hepatol 18:980-5. 2003
    It is known that lactoferrin serves as a source of iron for Helicobacter pylori in gastric mucosa. The present study was undertaken to investigate the relationship between lactoferrin and H...
  58. ncbi The lactoferrin receptor complex in Gram negative bacteria
    Amanda J Beddek
    Department of Microbiology and Infectious Diseases, University of Calgary, Rm G503A Health Sciences Center, 3330 Hospital Drive N W, Calgary, AB, Canada T2N 4N1
    Biometals 23:377-86. 2010
    ..environment on the mucosal surface where iron is complexed by the host iron-binding proteins transferrin and lactoferrin. Lactoferrin is also present in high concentrations at sites of inflammation where the cationic anti-microbial ..
  59. ncbi The synergistic effect of nisin and lactoferrin on the inhibition of Listeria monocytogenes and Escherichia coli O157:H7
    C A Murdock
    Rutgers, The State University of New Jersey, New Brunswick, New Jersey 08901 8520, USA
    Lett Appl Microbiol 44:255-61. 2007
    The goal of this study was to determine whether nisin and lactoferrin would act synergistically to inhibit the growth of Listeria monocytogenes and Escherichia coli O157:H7.
  60. ncbi Comparative analysis of the transferrin and lactoferrin binding proteins in the family Neisseriaceae
    A B Schryvers
    Department of Microbiology and Infectious Diseases, University of Calgary, Alta, Canada
    Can J Microbiol 35:409-15. 1989
    Intact cells of several bacterial species were tested for their ability to bind human transferrin and lactoferrin by a solid-phase binding assay using horseradish peroxidase conjugated transferrin and lactoferrin...
  61. ncbi Salivary lactoferrin and low-Mr mucin MG2 in Actinobacillus actinomycetemcomitans-associated periodontitis
    J Groenink
    Department of Oral Biochemistry, Academic Centre for Dentistry Amsterdam ACTA, The Netherlands
    J Clin Periodontol 26:269-75. 1999
    Concentrations and output of lactoferrin and of low-Mr mucin MG2 were determined in saliva of subjects suffering from Actinobacillus actinomycetemcomitans-associated periodontal disease and healthy subjects...
  62. ncbi Lactoferrin protects against development of hepatitis caused by sensitization of Kupffer cells by lipopolysaccharide
    M Yamaguchi
    Department of Nutritional Research, Nutrition Science Institute, Meiji Dairies Corporation, Odawara, Kanagawa, 250 0862 Japan
    Clin Diagn Lab Immunol 8:1234-9. 2001
    ..05 microg/g of body weight) 7 days after being primed with zymosan. Recombinant human lactoferrin (250 microg/g of body weight), intravenously administered 1 day before the injection of LPS, significantly ..
  63. ncbi Characterization of estrogen-responsive mouse lactoferrin promoter
    Y H Liu
    Developmental Endocrinology and Pharmacology Section, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709
    J Biol Chem 266:21880-5. 1991
    Mouse lactoferrin is expressed in a variety of tissues under different types of control...
  64. ncbi Lactoferrin binding to the rat asialoglycoprotein receptor requires the receptor's lectin properties
    D D McAbee
    Department of Chemistry and Biochemistry, California State University, Long Beach 90840 3903, USA
    Biochem J 348:113-7. 2000
    b>Lactoferrin binds to rat hepatic lectin 1 (RHL1), the major subunit of the asialoglycoprotein (ASGP) receptor, with high affinity, by a galactose-independent mechanism...
  65. ncbi Activated lactoferrin's ability to inhibit Candida growth and block yeast adhesion to the vaginal epithelial monolayer
    A Satyanarayan Naidu
    N terminus Research Laboratory, USA
    J Reprod Med 49:859-66. 2004
    To study in vitro growth-inhibitory effects of activated lactoferrin (ALF) against vaginal isolates of Candida species and to measure the ability of ALF to block interactions of Candida albicans and Candida glabrata to the vaginal ..
  66. ncbi Efficacy and tolerability of oral bovine lactoferrin compared to ferrous sulfate in pregnant women with iron deficiency anemia: a prospective controlled randomized study
    Carmine Nappi
    Department of Gynecology and Obstetrics, University of Naples Federico II, Via S Pansini 5, Naples, Italy
    Acta Obstet Gynecol Scand 88:1031-5. 2009
    To compare the effects of bovine lactoferrin with ferrous sulfate on iron nutritional status and to evaluate their tolerability in 100 pregnant women with iron deficiency anemia.
  67. ncbi Bactericidal effect of lactoferrin and lactoferrin chimera against halophilic Vibrio parahaemolyticus
    Nidia León-Sicairos
    Departamento de Investigacion, Hospital Pediátrico de Sinaloa, Blvd Constitución S N, Culiacan, Sin 80200, Mexico
    Biochimie 91:133-40. 2009
    ..The aim of this work was to investigate whether lactoferrin and some lactoferrin-peptides have bactericidal activity against Vibrio parahaemolyticus ATCC 17802, the ..
  68. ncbi A prospective study of faecal calprotectin and lactoferrin in the monitoring of acute radiation proctitis in prostate cancer treatment
    Andrea Hille
    Department of Radiotherapy and Radio Oncology, University of Gottingen, Gottingen, Germany
    Scand J Gastroenterol 43:52-8. 2008
    ..Acute radiation proctitis is a relevant complication of pelvic radiation. The purpose of this study was to investigate two markers of gut inflammation as non-invasive diagnostic tools to evaluate acute radiation proctitis...
  69. ncbi Methoxychlor stimulates the mouse lactoferrin gene promoter through a GC-rich element
    Zhiping Zhang
    Gene Regulation Section, Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Biochem Cell Biol 80:23-6. 2002
    The lactoferrin gene in the mouse uterus is a target gene for natural estrogens and xenoestrogens. One of the xenoestrogens is methyoxychlor, an insecticide that displays both estrogenic and antiandrogenic activities...
  70. ncbi Recombinant human lactoferrin treatment for global health issues: iron deficiency and acute diarrhea
    Delia R Bethell
    Ventria Bioscience, 4110 N Freeway Boulevard, Sacramento, California 95834, USA
    Biometals 17:337-42. 2004
    ..Recombinant human lactoferrin (rhLF), expressed and extracted from rice seed, is being evaluated by Ventria Bioscience for use as a dietary ..
  71. ncbi Human recombinant lactoferrin acts synergistically with antimicrobials commonly used in neonatal practice against coagulase-negative staphylococci and Candida albicans causing neonatal sepsis
    Mohan Pammi Venkatesh
    Baylor College of Medicine and Texas Children s Hospital, 6621 Fannin, MC WT 6 104, Houston, TX 77030, USA
    J Med Microbiol 57:1113-21. 2008
    ..Coagulase-negative staphylococci (CoNS) and Candida frequently cause neonatal sepsis at >72 h of age. Lactoferrin, which is present in human milk, is a component of innate immunity and has broad-spectrum antimicrobial ..
  72. ncbi Recombinant human lactoferrin has a potential to suppresses uterine cervical ripening in preterm delivery in animal model
    K Yakuwa
    Department of Obstetrics and Gynecology, Showa University School of Medicine, 1 5 8 Hatanodai, Shinagawa ku, Tokyo 142 8666, Japan
    Arch Gynecol Obstet 275:331-4. 2007
    To investigate the effect of recombinant human lactoferrin (rhLF) on cervical ripening using a rabbit model in which preterm labor was induced by bacterial endotoxin lipopolysaccharide (LPS).
  73. ncbi Microbicidal effect of the lactoferrin peptides lactoferricin17-30, lactoferrampin265-284, and lactoferrin chimera on the parasite Entamoeba histolytica
    Fernando López-Soto
    Laboratorio de Bioquímica de Proteínas, Departamento de Medicina y Ciencias de la Salud, Universidad de Sonora, Blvd Luis Encinas y Rosales, Col Centro, 83000 Hermosillo, Sonora, Mexico
    Biometals 23:563-8. 2010
    ..In some cases, trophozoites can travel to the liver leading to hepatic abscesses and death. Recently, lactoferrin and lactoferricin B have been shown to be amoebicidal in axenic cultures...
  74. ncbi Expression of bovine lactoferrin and lactoferrin N-lobe by recombinant baculovirus and its antimicrobial activity against Prototheca zopfii
    Tetsuya Tanaka
    Graduate School of Agriculture, Hokkaido University, Sapporo, Japan
    Biochem Cell Biol 81:349-54. 2003
    b>Lactoferrin (LF) is a multifunctional, iron-binding glycoprotein found in secretory fluids of mammals...
  75. ncbi Quadruple therapy with lactoferrin for Helicobacter pylori eradication: a randomised, multicentre study
    A Zullo
    Gastroenterology and Digestive Endoscopy, Nuovo Regina Margherita Hospital, Rome, Italy
    Dig Liver Dis 37:496-500. 2005
    Helicobacter pylori eradication rate with standard triple therapies is decreasing. Recently, lactoferrin administration has been shown to significantly increase the cure rate of 7-day rabeprazole, clarithromycin and tinidazole triple ..
  76. ncbi Effect of lactoferrin on the growth performance, intestinal morphology, and expression of PR-39 and protegrin-1 genes in weaned piglets
    Y Wang
    Institute of Feed Science, Zhejiang University, The Key Laboratory of Molecular Animal Nutrition, Ministry of Education, No 164 Qiutao North Road, Hangzhou 310029, P R China
    J Anim Sci 84:2636-41. 2006
    ..female pigs (Duroc x Landrace x Yorkshire) were used in a 15-d growth experiment to investigate the effect of lactoferrin on growth performance, intestinal morphology, and expression of PR-39 and protegrin-1 genes...
  77. ncbi Long term facilitation of phrenic motor output
    D D Fuller
    Department of Comparative Biosciences, University of Wisconsin, 2015 Linden Drive West, Madison, WI 53706, USA
    Respir Physiol 121:135-46. 2000
    ....
  78. ncbi DNA, oligosaccharides, and mononucleotides stimulate oligomerization of human lactoferrin
    Alexander G Nevinskii
    Institute of Chemical Biology and Fundamental Medicine, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia
    J Mol Recognit 22:330-42. 2009
    Using small-angle X-ray scattering (SAXS), light scattering (LS), and soft laser ablation we have shown that lactoferrin (LF) in solution at neutral pH is oligomerized in the absence of salt or at physiological salt concentrations...
  79. ncbi High level expression of functionally active human lactoferrin in silkworm larvae
    Tao Liu
    Institute of Biochemistry, College of Life Sciences, Zhejiang University, Hangzhou 310029, China
    J Biotechnol 118:246-56. 2005
    In this paper, recombinant human lactoferrin (rhLf) was expressed very well using Bombyx mori nuclear polyhedrosis baculovirus expression system...
  80. ncbi Developmental gene expression of lactoferrin and effect of dietary iron on gene regulation of lactoferrin in mouse mammary gland
    Y Wang
    The Key Laboratory of Molecular Animal Nutrition, Ministry of Education, Institute of Feed Science, Zhejiang University, Hangzhou 310029, China
    J Dairy Sci 88:2065-71. 2005
    This study evaluated the developmental gene expression of lactoferrin (LF) and the effect of supplementary iron on gene expression of LF in the mammary gland of mice using semi-quantitative reverse transcription-polymerase chain reaction ..
  81. ncbi Fecal lactoferrin and calprotectin after ileocolonic resection for Crohn's disease
    Marco Scarpa
    Clinica Chirurgica I, Dipartimento di Scienze Chirurgiche e Gastroenterologiche, University of Padova, Padova, Italy
    Dis Colon Rectum 50:861-9. 2007
    This study was designed to assess the role of fecal lactoferrin and calprotectin as markers of intestinal inflammation in patients with Crohn's disease who have undergone ileocolonic resection.
  82. ncbi Antibiotic tolerance induced by lactoferrin in clinical Pseudomonas aeruginosa isolates from cystic fibrosis patients
    María T Andrés
    Laboratory of Oral Microbiology, School of Stomatology, University of Oviedo, Oviedo, Spain
    Antimicrob Agents Chemother 49:1613-6. 2005
    b>Lactoferrin-induced cell depolarization and a delayed tobramycin-killing effect on Pseudomonas aeruginosa cells were correlated...
  83. ncbi Lactoferrin in chronic pancreatitis
    Chun Xiang Jin
    Second Clinical College of Norman Bethune Medical Division, Jilin University, Changchun, China
    JOP 10:237-41. 2009
    The present review is focused on the clinical significance of lactoferrin in pancreatic secretions and stone formation in chronic pancreatitis, and of serum anti-lactoferrin antibody in autoimmune pancreatitis...
  84. ncbi Nucleotide sequence of human lactoferrin cDNA
    M J Powell
    Delta Biotechnology Ltd, Nottingham, UK
    Nucleic Acids Res 18:4013. 1990
  85. ncbi Flagellum-mediated biofilm defense mechanisms of Pseudomonas aeruginosa against host-derived lactoferrin
    Jeff G Leid
    Department of Biological Sciences, Northern Arizona University, Flagstaff, Arizona 86001, USA
    Infect Immun 77:4559-66. 2009
    ..a cytokine cross talk network between mononuclear cells and neutrophils that was essential to the production of lactoferrin and bacterial killing...
  86. ncbi Lactoferrin increases (172Thr)AMPK phosphorylation and insulin-induced (p473Ser)AKT while impairing adipocyte differentiation
    J M Moreno-Navarrete
    Unit of Diabetes, Endocrinology and Nutrition Unit, Biomedical Research Institute of Girona, Hospital de Girona Dr Josep Trueta, and CIBER Fisiopatologia Obesidad y Nutricion CB06 03 010 Instituto de Salud Carlos III, Girona, Spain
    Int J Obes (Lond) 33:991-1000. 2009
    b>Lactoferrin is a pleiotropic glycoprotein of the innate immune system with known effects on immunomodulation and cell differentiation...
  87. ncbi Neutrophil beta(2)-microglobulin and lactoferrin content in renal failure patients
    R Deicher
    Universitätsklinik für Innere Medizin III, Klinische Abteilung für Nephrologie und Dialyse, Wein, Austria
    Am J Kidney Dis 35:1117-26. 2000
    ..In the present study, we measured the PMNL content of beta(2)-microglobulin (beta(2)m) and lactoferrin in different states of renal insufficiency and after kidney transplantation...
  88. ncbi Apo- and holo-lactoferrin are both internalized by lactoferrin receptor via clathrin-mediated endocytosis but differentially affect ERK-signaling and cell proliferation in Caco-2 cells
    Rulan Jiang
    Department of Nutrition, University of California, Davis, California 95616, USA
    J Cell Physiol 226:3022-31. 2011
    b>Lactoferrin (Lf) is a major iron-binding and multi-functional protein in exocrine fluids such as breast milk and mucosal secretions...
  89. ncbi Nasal mucosa expression of lactoferrin in patients with chronic rhinosinusitis
    Alkis J Psaltis
    Department of Surgery Otorhinolaryngology Head and Neck Surgery, The Queen Elizabeth Hospital, and the University of Adelaide, Adelaide, SA, Australia
    Laryngoscope 117:2030-5. 2007
    Antimicrobial peptides, such as lactoferrin, are an important component of the innate immune system. They offer the body a first line defense against a wide range of invading pathogens...
  90. ncbi Utility of transfer factor to detect different bronchodilator responses in patients with chronic obstructive pulmonary disease
    J L Izquierdo-Alonso
    Pneumology Department, Hospital Universitario de Guadalajara, Spain
    Respiration 65:282-8. 1998
    ..We suggest that transfer factor should be taken into consideration when bronchial response is evaluated in large clinical trials...
  91. ncbi Oral lactoferrin results in T cell-dependent tumor inhibition of head and neck squamous cell carcinoma in vivo
    Jeffrey S Wolf
    Department of Otorhinolaryngology Head and Neck Surgery, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Clin Cancer Res 13:1601-10. 2007
    Human lactoferrin is a naturally occurring glycoprotein that inhibits cancer growth. Our purpose was to evaluate recombinant human lactoferrin as a chemotherapeutic agent against head and neck squamous cell carcinoma.
  92. ncbi Phrenic long-term facilitation is robust to hypercapnia and hypocapnia but not hyperventilatory hypotension under PEEP
    Michelle McGuire
    Harvard MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Bldg 56 046, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
    Respir Physiol Neurobiol 158:107-11. 2007
    ..The results suggest that LTF, once developed, is highly robust to changes in CO(2) levels and is attenuated only after severe hypotension secondary to excessive hyperventilation under PEEP...
  93. ncbi The effect of recombinant human lactoferrin on growth and the antibiotic susceptibility of the cystic fibrosis pathogen Burkholderia cepacia complex when cultured planktonically or as biofilms
    Emma M Caraher
    Centre of Microbial Host Interaction, Department of Science, Institute of Technology Tallaght ITT Dublin, Tallaght, Dublin 24, Ireland
    J Antimicrob Chemother 60:546-54. 2007
    ..The objectives of this study were to investigate the effects of recombinant human lactoferrin (rHL) on planktonic and biofilm cultures of Bcc organisms and to establish whether lactoferrin alters the ..
  94. ncbi Structures involved in the interaction of Porphyromonas gingivalis fimbriae and human lactoferrin
    H T Sojar
    Department of Oral Biology, School of Dental Medicine, State University of New York at Buffalo, 14214, USA
    FEBS Lett 422:205-8. 1998
    The ability of laboratory and clinical strains of Porphyromonas gingivalis to bind lactoferrin has been assessed (FEMS Immunology and Medical Microbiology, 1996, 14, 135-143). Relative binding for P...
  95. ncbi Lactoferrin decreases primary bovine mammary epithelial cell viability and casein expression
    Lisa G Riley
    Centre for Advanced Technologies in Animal Reproduction and Genetics, Faculty of Veterinary Science, University of Sydney, Australia
    J Dairy Res 75:135-41. 2008
    The concentration of lactoferrin (LTF) in milk varies during lactation, rising sharply during involution...
  96. ncbi Isolation of lactoferrin cDNA from a human myeloid library and expression of mRNA during normal and leukemic myelopoiesis
    T A Rado
    Department of Medicine, University of Alabama at Birmingham
    Blood 70:989-93. 1987
    b>Lactoferrin is a major constituent of polymorphonuclear leukocyte granules and is present in mature neutrophils but not in blasts or promyelocytes...
  97. ncbi The N1 domain of human lactoferrin is required for internalization by caco-2 cells and targeting to the nucleus
    Yasushi A Suzuki
    Department of Nutrition, University of California, Davis, California 95616, USA
    Biochemistry 47:10915-20. 2008
    Human lactoferrin (hLf) has been shown to interact with cells from the Caco-2 human small intestinal cell line. There currently is little information about the molecular details of its interaction...
  98. ncbi Lactoferrin is a survival factor for neutrophils in rheumatoid synovial fluid
    S H Wong
    Rheumatology Research Group, MRC Centre for Immune Regulation, Institute of Biomedical Research, Birmingham University, Birmingham, UK
    Rheumatology (Oxford) 48:39-44. 2009
    b>Lactoferrin is an iron-binding protein that is released from activated neutrophils at sites of inflammation and has anti-microbial as well as anti-inflammatory properties...
  99. ncbi Differential effects of prophylactic, concurrent and therapeutic lactoferrin treatment on LPS-induced inflammatory responses in mice
    M L Kruzel
    University of Texas, Health Science Center at Houston, University of Houston, Houston, Texas 77030, USA
    Clin Exp Immunol 130:25-31. 2002
    ..b>Lactoferrin, an iron binding protein, provides a natural feedback mechanism to control the development of such metabolic ..
  100. ncbi Lactoferrin (Lf): Retinoid interactions in the mammary glands of transgenic mice overexpressing human Lf
    Craig R Baumrucker
    Department of Dairy and Animal Science, The Pennsylvania State University, University Park, 16802, USA
    Mol Cell Endocrinol 251:56-66. 2006
    ..Studies with retinoid reporter constructs transfected in mammary cell lines suggests that lactoferrin (Lf) affects retinoid signaling pathways and alters apoptosis...
  101. ncbi Enhancement of the activity of novobiocin against Escherichia coli by lactoferrin
    M S Sanchez
    Upjohn Company, Kalamazoo, MI 49001, USA
    J Dairy Sci 82:494-9. 1999
    ..that were isolated from cases of bovine mastitis was determined in timekill studies in the presence of bovine lactoferrin. Lactoferrin alone did not affect the growth of any of the strains of E. coli. A combination of 1...

Research Grants76

  1. HEMIN UTILIZATION BY P GINGIVALIS
    Caroline Genco; Fiscal Year: 1999
    ..Iron sources will include iron bound to transferrin, lactoferrin, albumin, haptoglobin and hemopexin, sources commonly found in vivo...
  2. Recombinant Lactoferrin and Necrotizing Enterocolitis
    Karel Petrak; Fiscal Year: 2004
    This feasibility study is based on our hypothesis that recombinant human lactoferrin [rhLF] can prevent or reduce severity of necrotizing enterocolitis [NEC]. NEC is mainly a disease of very low birth weight [VLBW] human infants...
  3. IRON ACQUISITION IN BORDETELLA PERTUSSIS
    SANDRA KAY ARMSTRONG; Fiscal Year: 2010
    ..means by which Bordetella cells use host neuroendocrine stress hormones to obtain the iron from transferrin and lactoferrin. PUBLIC HEALTH RELEVANCE: Nearly all bacteria require iron for growth and pathogenic bacteria must be able ..
  4. REGULATION OF GRANULOCYTE SECRETION
    Laurence Boxer; Fiscal Year: 1993
    ..leukocytes (PMN), the NADPH oxidase can be assembled on specific granule (SG) membranes which contain lactoferrin (LF) and cytochrome b558...
  5. Structure/function studies of lactoferrin as a protease
    Andrew Plaut; Fiscal Year: 2005
    DESCRIPTION: We have recently discovered that human lactoferrin, a member of the lactotransferrin family of iron binding proteins, has proteolytic activity...
  6. A TRANSCRIPTIONAL PROGRAM REGULATING MYELOPOIESIS
    Alan Friedman; Fiscal Year: 2004
    ..32D cl3 myeloid cells were developed expressing C/EBPa-ER or PU.1-ER. Activation of C/EBPa-ER increased MPO, lactoferrin, and G-CSF receptor mRNA expression and induced a neutrophilic morphology and a G1 cell cycle arrest...
  7. CDP/CUT AND MYELOID DIFFERENTIATION
    Nancy Berliner; Fiscal Year: 2001
    ..We have identified a region within the human lactoferrin (LF) gene promoter which confers a silencing effect on the expression of reporter gene plasmids in LF non-..
  8. PspA: A Potential Pneumococcal Vaccine Component
    David E Briles; Fiscal Year: 2010
    ..PspA also keeps apolactoferrin from killing Sp by neutralizing lactoferrin and its cationic peptide lactoferricin...
  9. Iron acquisition mechanisms utilized by Neisseria gonorrhoeae
    Cynthia Nau Cornelissen; Fiscal Year: 2010
    ..iron from a variety of host-specific sources, including from the iron-binding glycoproteins, transferrin and lactoferrin. Iron transport from these iron-binding proteins is accomplished by an integral, outer membrane transporter, ..
  10. PspA: A Potential Pneumococcal Vaccine Component
    David Briles; Fiscal Year: 2009
    ..PspA also keeps apolactoferrin from killing Sp by neutralizing lactoferrin and its cationic peptide lactoferricin...
  11. PspA: A Potential Pneumococcal Vaccine Component
    David Briles; Fiscal Year: 2009
    ..PspA also keeps apolactoferrin from killing Sp by neutralizing lactoferrin and its cationic peptide lactoferricin...
  12. Formula with antimicrobials to decrease infant mortality
    Koteswara Chintalacharuvu; Fiscal Year: 2006
    ..S-IgA, lactoferrin and lysozyme in breast milk are the major antimicrobial factors...
  13. Iron acquisition systems in Neisseria gonorrhoeae
    CYNTHIA CORNELISSEN; Fiscal Year: 2007
    ..Although mechanisms for utilization of host iron-binding proteins, including transferrin and lactoferrin, have been most thoroughly characterized, expression of these receptors is not required for growth of the ..
  14. Localized Aggressive Periodontitis: Microbial & Host Markers for Susceptibility
    Daniel Fine; Fiscal Year: 2009
    ..These factors include: iron-saturation of lactoferrin, IgA antibody titers to Aa adhesins, a Growth Modifying Factor (GMF) that killls Gram+ pioneer plaque microbes ..
  15. Localized Aggressive Periodontitis: Microbial & Host Markers for Susceptibility
    Daniel Fine; Fiscal Year: 2009
    ..These factors include: iron-saturation of lactoferrin, IgA antibody titers to Aa adhesins, a Growth Modifying Factor (GMF) that killls Gram+ pioneer plaque microbes ..
  16. Localized Aggressive Periodontitis: Microbial & Host Markers for Susceptibility
    Daniel H Fine; Fiscal Year: 2010
    ..These factors include: iron-saturation of lactoferrin, IgA antibody titers to Aa adhesins, a Growth Modifying Factor (GMF) that killls Gram+ pioneer plaque microbes ..
  17. Bioactivity and Vitamins in Flash-heated Breastmilk
    Caroline Chantry; Fiscal Year: 2005
    ..1) vitamin content and protein digestibility; 2) key bioactive proteins (immunoglobulin A, lysozyme and lactoferrin); 3) antibacterial activity...
  18. Mammalian Lactoferrin Receptors: Structure and Function
    Bo Lonnerdal; Fiscal Year: 2007
    b>Lactoferrin (Lf), an 80 kD glycoprotein that can bind two atoms of Fe(lll), is a major protein in human milk, and also present in exocrine secretions, e.g. pancreatic fluid and bile, and in neutrophils...