lactoferrin

Summary

Gene Symbol: lactoferrin
Description: lactotransferrin
Alias: GIG12, HEL110, HLF2, epididymis luminal protein 110, growth-inhibiting protein 12, kaliocin-1, lactoferricin, lactoferroxin, neutrophil lactoferrin, talalactoferrin
Species: human

Top Publications

  1. ncbi Human delta-lactoferrin is a transcription factor that enhances Skp1 (S-phase kinase-associated protein) gene expression
    Christophe Mariller
    Unite de Glycobiologie Structurale et Fonctionnelle, Unité Mixte de Recherche 8576 CNRS Université des Sciences et Technologies de Lille1, Villeneuve d Ascq, France
    FEBS J 274:2038-53. 2007
  2. ncbi Efficacy of a lactoferrin-penicillin combination to treat {beta}-lactam-resistant Staphylococcus aureus mastitis
    D Petitclerc
    Crea Biopharma Inc, Sherbrooke, Quebec, Canada J1E 4K8
    J Dairy Sci 90:2778-87. 2007
  3. ncbi Serum lactoferrin and immunoglobulin G concentrations in healthy or ill neonatal foals and healthy adult horses
    Michelle Henry Barton
    Department of Large Animal Medicine, College of Veterinary Medicine, The University of Georgia, Athens, GA, USA
    J Vet Intern Med 20:1457-62. 2006
  4. ncbi Down regulation of 3p genes, LTF, SLC38A3 and DRR1, upon growth of human chromosome 3-mouse fibrosarcoma hybrids in severe combined immunodeficiency mice
    Irina D Kholodnyuk
    Microbiology and Tumour Biology Center, Karolinska Institute, Stockholm, Sweden
    Int J Cancer 119:99-107. 2006
  5. ncbi Genetic and epigenetic inactivation of LTF gene at 3p21.3 in lung cancers
    Hironobu Iijima
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Maebashi, Gunma 371 8511, Japan
    Int J Cancer 118:797-801. 2006
  6. pmc Comparison of human immunodeficiency virus type 1-specific inhibitory activities in saliva and other human mucosal fluids
    Shamim H Kazmi
    Oral AIDS Research Unit, Department of Oral Medicine and Immunology, King s College London Dental Institute at Guy s, King s College, and St Thomas Hospitals, Floor 28, Guy s Tower, King s College London, London SE1 9RT, United Kingdom
    Clin Vaccine Immunol 13:1111-8. 2006
  7. pmc Human lactoferrin but not lysozyme neutralizes HSV-1 and inhibits HSV-1 replication and cell-to-cell spread
    Hannamari Valimaa
    Institute of Dentistry, University of Turku, Turku, Finland
    Virol J 6:53. 2009
  8. ncbi Antiviral activities of lactoferrin
    B W van der Strate
    Department of Pharmacokinetics and Drug Delivery, Groningen University Institute for Drug Exploration GUIDE, A Deusinglaan 1, 9713 AV Groningen, The Netherlands
    Antiviral Res 52:225-39. 2001
  9. ncbi Identification of an import signal for, and the nuclear localization of, human lactoferrin
    S Penco
    Department of Oncology, Biology and Genetics, University of Genoa, Viale Benedetto XV, 6 Genoa, Italy
    Biotechnol Appl Biochem 34:151-9. 2001
  10. doi Endocytosis and trafficking of human lactoferrin in macrophage-like human THP-1 cells (1)
    Paula Florian
    Institute of Biochemistry of the Romanian Academy, Spl Independentei 296, Bucharest 17 060031, Romania
    Biochem Cell Biol 90:449-55. 2012

Detail Information

Publications272 found, 100 shown here

  1. ncbi Human delta-lactoferrin is a transcription factor that enhances Skp1 (S-phase kinase-associated protein) gene expression
    Christophe Mariller
    Unite de Glycobiologie Structurale et Fonctionnelle, Unité Mixte de Recherche 8576 CNRS Université des Sciences et Technologies de Lille1, Villeneuve d Ascq, France
    FEBS J 274:2038-53. 2007
    Delta-lactoferrin is a cytoplasmic lactoferrin isoform that can locate to the nucleus, provoking antiproliferative effects and cell cycle arrest in S phase...
  2. ncbi Efficacy of a lactoferrin-penicillin combination to treat {beta}-lactam-resistant Staphylococcus aureus mastitis
    D Petitclerc
    Crea Biopharma Inc, Sherbrooke, Quebec, Canada J1E 4K8
    J Dairy Sci 90:2778-87. 2007
    ..The efficacy of intramammary (IM) treatments containing penicillin G (PG) alone or a combination of PG and bovine lactoferrin (bLF) was evaluated using a model of experimentally induced chronic bovine mastitis caused by a clinical ..
  3. ncbi Serum lactoferrin and immunoglobulin G concentrations in healthy or ill neonatal foals and healthy adult horses
    Michelle Henry Barton
    Department of Large Animal Medicine, College of Veterinary Medicine, The University of Georgia, Athens, GA, USA
    J Vet Intern Med 20:1457-62. 2006
    b>Lactoferrin is a colostral glycoprotein with antimicrobial properties.
  4. ncbi Down regulation of 3p genes, LTF, SLC38A3 and DRR1, upon growth of human chromosome 3-mouse fibrosarcoma hybrids in severe combined immunodeficiency mice
    Irina D Kholodnyuk
    Microbiology and Tumour Biology Center, Karolinska Institute, Stockholm, Sweden
    Int J Cancer 119:99-107. 2006
    ..Our data indicate these genes as putative tumour suppressor genes...
  5. ncbi Genetic and epigenetic inactivation of LTF gene at 3p21.3 in lung cancers
    Hironobu Iijima
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Maebashi, Gunma 371 8511, Japan
    Int J Cancer 118:797-801. 2006
    ..The lactotransferrin gene (LTF, also referred to as the lactoferrin gene, LF) is located at 3p21...
  6. pmc Comparison of human immunodeficiency virus type 1-specific inhibitory activities in saliva and other human mucosal fluids
    Shamim H Kazmi
    Oral AIDS Research Unit, Department of Oral Medicine and Immunology, King s College London Dental Institute at Guy s, King s College, and St Thomas Hospitals, Floor 28, Guy s Tower, King s College London, London SE1 9RT, United Kingdom
    Clin Vaccine Immunol 13:1111-8. 2006
    ..Incubation of unfractionated and fractionated whole saliva with antibodies raised against human lactoferrin (hLf), secretory leukocyte protease inhibitor (SLPI), and, to a lesser extent, MG2 (high-molecular-weight ..
  7. pmc Human lactoferrin but not lysozyme neutralizes HSV-1 and inhibits HSV-1 replication and cell-to-cell spread
    Hannamari Valimaa
    Institute of Dentistry, University of Turku, Turku, Finland
    Virol J 6:53. 2009
    ..In the current study, we investigated the anti-HSV-1 activity of human lactoferrin (hLf) and lysozyme (hLz), two highly cationic polypeptides of the mucosal innate defence system...
  8. ncbi Antiviral activities of lactoferrin
    B W van der Strate
    Department of Pharmacokinetics and Drug Delivery, Groningen University Institute for Drug Exploration GUIDE, A Deusinglaan 1, 9713 AV Groningen, The Netherlands
    Antiviral Res 52:225-39. 2001
    b>Lactoferrin (LF) is an iron binding glycoprotein that is present in several mucosal secretions. Many biological functions have been ascribed to LF...
  9. ncbi Identification of an import signal for, and the nuclear localization of, human lactoferrin
    S Penco
    Department of Oncology, Biology and Genetics, University of Genoa, Viale Benedetto XV, 6 Genoa, Italy
    Biotechnol Appl Biochem 34:151-9. 2001
    Many different unique functions have been attributed to lactoferrin (Lf), including DNA and RNA binding, and transport into the nucleus, where Lf binds to specific sequences and activates transcription...
  10. doi Endocytosis and trafficking of human lactoferrin in macrophage-like human THP-1 cells (1)
    Paula Florian
    Institute of Biochemistry of the Romanian Academy, Spl Independentei 296, Bucharest 17 060031, Romania
    Biochem Cell Biol 90:449-55. 2012
    Different cell types have been reported to internalize lactoferrin (Lf) by specific or nonspecific receptors. Our studies focused on the endocytic pathway of human Lf in macrophage-like THP-1 cells...
  11. doi Human lactoferrin suppresses TNF-α-induced intercellular adhesion molecule-1 expression via competition with NF-κB in endothelial cells
    Chan Woo Kim
    College of Life Science and Graduate School of Biotechnology, Kyung Hee University, Yongin 446 701, Republic of Korea
    FEBS Lett 586:229-34. 2012
    b>Lactoferrin (Lf) is known to have anti-inflammatory activity, but the mechanisms of action by Lf remain to be elucidated...
  12. doi Lactoferrin is a novel predictor of fatal ischemic heart disease in diabetes mellitus type 2: long-term follow-up of the HUNT 1 study
    Inga Thorsen Vengen
    Department of Laboratory Medicine, Children s and Women s Health, Norwegian University of Science and Technology, and Department of Cardiology, Trondheim University Hospital, Trondheim, Norway
    Atherosclerosis 212:614-20. 2010
    ..aim of this study was to compare the predictive values of two neutrophil degranulation products, myeloperoxidase and lactoferrin, on long-term risk for fatal ischemic heart disease in persons with newly diagnosed diabetes and controls.
  13. ncbi Differential modulation of human lactoferrin activity against both R5 and X4-HIV-1 adsorption on epithelial cells and dendritic cells by natural antibodies
    Hela Saidi
    Universite Rene Descartes Paris V, Unité Institut National de la Recherche et de la Santé INSERM Internationale 743 d Immunologie Humaine, Centres de Recherches Biomédicales des Cordeliers, Paris, France
    J Immunol 177:5540-9. 2006
    Human lactoferrin (Lf) is an iron binding glycoprotein that is present in several mucosal secretions. Many biological functions have been ascribed to Lf...
  14. ncbi Surface nucleolin participates in both the binding and endocytosis of lactoferrin in target cells
    Dominique Legrand
    Institut Fédératif de Recherche n degrees 118, Universite des Sciences et Technologies de Lille, Villeneuve d Ascq, France
    Eur J Biochem 271:303-17. 2004
    b>Lactoferrin (Lf), a multifunctional molecule present in mammalian secretions and blood, plays important roles in host defense and cancer...
  15. ncbi High prevalence of autoantibodies against carbonic anhydrase II and lactoferrin in type 1 diabetes: concept of autoimmune exocrinopathy and endocrinopathy of the pancreas
    Takao Taniguchi
    Department of Internal Medicine, Ohtsu Red Cross Hospital, Shiga, Japan
    Pancreas 27:26-30. 2003
    ..Dysfunction of the exocrine as well as the endocrine pancreas has been reported in type 1 diabetes. Lymphocytic infiltration of the exocrine pancreas is observed in approximately half of Japanese type 1 diabetic patients...
  16. ncbi Lactoferrin down-modulates the activity of the granulocyte macrophage colony-stimulating factor promoter in interleukin-1 beta-stimulated cells
    S Penco
    Institute of Biology and Genetics, University of Genova, Italy
    J Biol Chem 270:12263-8. 1995
    The human neutrophil lactoferrin (Lf), a cationic iron-binding glycoprotein, has an inhibitor role on granulocyte macrophage colony-stimulating factor (GM-CSF) production via interleukin-1 (IL-1)...
  17. ncbi Multifunctional roles of lactoferrin: a critical overview
    P P Ward
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Cell Mol Life Sci 62:2540-8. 2005
    b>Lactoferrin (LF) is a member of the transferrin family that is expressed and secreted by glandular epithelial cells and is found in the secondary granules of neutrophils...
  18. pmc Human lactoferrin interacts with soluble CD14 and inhibits expression of endothelial adhesion molecules, E-selectin and ICAM-1, induced by the CD14-lipopolysaccharide complex
    S Baveye
    Laboratoire de Chimie Biologique et Unité Mixte de Recherche no 8576 du Centre National de la Recherche Scientifique, Universite des Sciences et Technologies de Lille, 59655 Villeneuve d Ascq cedex, France
    Infect Immun 68:6519-25. 2000
    ..b>Lactoferrin (Lf), a LPS-chelating glycoprotein, protects animals against septic shock...
  19. ncbi The antiviral activity of the milk protein lactoferrin against the human immunodeficiency virus type 1
    Ben Berkhout
    Department of Human Retrovirology, Academic Medical Center, University of Amsterdam, Meibergdreef 15, 1105 AZ Amsterdam, The Netherlands
    Biometals 17:291-4. 2004
    ..In this manuscript, we review the antiviral properties of the milk protein lactoferrin (LF)...
  20. pmc Lactoferrin prevents dendritic cell-mediated human immunodeficiency virus type 1 transmission by blocking the DC-SIGN--gp120 interaction
    Fedde Groot
    Department of Human Retrovirology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Virol 79:3009-15. 2005
    ..tested proteins from milk and serum for their ability to block DC-mediated HIV-1 transmission, of which bovine lactoferrin (bLF) is the most potent inhibitor...
  21. ncbi Genetic and epigenetic alterations of LTF at 3p21.3 in nasopharyngeal carcinoma
    Hong Mei Yi
    Cancer Research Institute, Xiang Ya School of Medicine, Central South University, Changsha, Hunan, P R China
    Oncol Res 16:261-72. 2006
    To investigate the roles of lactotransferrin gene (LTF, also referred to as the lactoferrin gene, LF), located at 3p21...
  22. ncbi Bovine whey fractionation based on cation-exchange chromatography
    R Hahn
    Institute of Applied Microbiology, University of Agriculture, Forestry and Biotechnology, Vienna, Austria
    J Chromatogr A 795:277-87. 1998
    ..A fractionation scheme for the economically interesting proteins, such as IgG, lactoferrin and lactoperoxidase, based on cation exchangers was the goal of our investigations...
  23. ncbi Metal storage and transport proteins increase after exposure of the rat lung to an air pollution particle
    A J Ghio
    National Health and Environmental Effects Research Laboratory, Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Toxicol Pathol 26:388-94. 1998
    ..We tested the hypothesis that the concentrations of both lactoferrin and ferritin in the rat lung increase after exposure to a metal-rich emission source air pollution particle...
  24. ncbi [Disturbed neutrophil activation in pneumonia during medicinal immunosuppression]
    J Braun
    Medizinische Klinik II,
    Pneumologie 51:1037-42. 1997
    ..cell differential the BALF concentrations of the neutrophil degranulation products myeloperoxidase (MPO) and lactoferrin were determined using immunoluminometric assays...
  25. ncbi Subcellular distribution of urokinase and urokinase receptor in human neutrophils determined by immunoelectron microscopy
    T L Pedersen
    Department of Pathology, Herlev Hospital, University of Copenhagen, Denmark
    Ultrastruct Pathol 24:175-82. 2000
    ..markers for well-defined subtypes of granules: matrix metalloproteinase type-9 (MMP-9) for gelatinase granules, lactoferrin (LF) for specific granules, and myeloperoxidase (MPO) and neutrophil elastase (NE) for primary granules...
  26. ncbi Abnormal cell differentiation and p21 expression of endometrial epithelial cells following developmental exposure to diethylstilbestrol (DES)
    A Yoshida
    Laboratory of Experimental Pathology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Toxicol Pathol 28:237-45. 2000
    ..These cells also showed increased expression of lactoferrin, a sensitive protein marker of estrogen exposure, although the staining intensity decreased after exposure ..
  27. ncbi Immunohistochemical study of ceruloplasmin, lactoferrin and secretory component expression in neoplastic and non-neoplastic thyroid gland diseases
    A Kondi-Pafiti
    Department of Pathology, Athens University, School of Medicine, Areteion Hospital, Greece
    Acta Oncol 39:753-6. 2000
    The expression of lactoferrin (LF), ceruloplasmin (CP) and secretory component (SC) in various thyroid diseases was investigated using an immunohistochemical method...
  28. ncbi Towards a closed eye model of the pre-ocular tear layer
    R A Sack
    SUNY, College of Optometry, 100 East 20 Street, Manhattan, NY 10010, USA
    Prog Retin Eye Res 19:649-68. 2000
    ..an inducible, neurologically controlled, lacrimal secretion containing among other proteins primarily lysozyme, lactoferrin and tear specific lipocalin, to a much slower, constitutive-type of secretion, composed almost exclusively of ..
  29. ncbi [Reverting effect of cysteine on the suppression by glucose or dexamethasone of anti-Candida activity of human neutrophils]
    T Tansho
    Department of Surgery II, Teikyo University School of Medicine
    Kansenshogaku Zasshi 72:727-37. 1998
    ..Correspondingly, cysteine augmented production of lactoferrin by stimulated neutrophils; which functions as a major effector molecule in growth inhibition of Candida by ..
  30. ncbi [Myeloperoxidase, lactoferrin and elastase in bronchoalveolar lavage and plasma in pneumonia]
    J Braun
    ,
    Pneumologie 46:141-7. 1992
    ..BALF) and in plasma, the concentration of the locally produced granulocyte products myeloperoxidase (MPO), lactoferrin (LF) and elastase-alpha 1 proteinase complex (ELA) as well as of the alpha 1 proteinase inhibitor (alpha 1 Pi) ..
  31. ncbi Thin-layer ion-exchange chromatography of proteins
    Q Luo
    Department of Materials Science and Engineering, University of Utah, Salt Lake City 84112-0560, USA
    J Chromatogr A 816:97-105. 1998
    ..The net charges were calculated for four model proteins, albumin, transferrin, lactoferrin and lysozyme, under different pH values...
  32. ncbi Two ion-exchange chromatographic methods for the isolation of antibacterial peptides from lactoferrin. In situ enzymatic hydrolysis on an ion-exchange membrane
    I Recio
    Department of Product Technology, NIZO Food Research, Ede, The Netherlands
    J Chromatogr A 831:191-201. 1999
    ..After removal of weakly bound material by washing with ammonia, highly purified lactoferricin-B (LFcin-B) was obtained in a single step by elution with 2 M NaCl...
  33. ncbi A rapid and efficient physiologic chemical method of labeling plasma proteins with indium-111
    D W Wong
    Department of Radiology, King Drew Medical Center U C L A 90059
    Int J Rad Appl Instrum A 38:1067-72. 1987
    ..Human serum albumin, IgG, fibrinogen, transferrin, lactoferrin and the enzyme bovine thrombin had been successfully labeled with exceptionally high labeling yields of greater ..
  34. ncbi Determination of the minor whey protein bovine lactoferrin in cheese whey concentrates with capillary electrophoresis
    P Riechel
    , , Germany
    J Chromatogr A 817:187-93. 1998
    In our present work we present the determination of bovine lactoferrin in whey concentrates as they are typically produced by milk and cheese industry after production of cheese...
  35. ncbi [Bacteriostatic activity of bovine colostrum]
    H Ushijima
    Department of Enteroviruses, National Institute of Health
    Kansenshogaku Zasshi 65:54-60. 1991
    ..of non immunized bovine colostrum immunoglobulin, we studied the bacteriostatic activity of the immunoglobulin, lactoferrin and lactoferrin Fe by using the automated antimicrobial susceptibility testing system...
  36. pmc Differential spatiotemporal regulation of lactoferrin and progesterone receptor genes in the mouse uterus by primary estrogen, catechol estrogen, and xenoestrogen
    S K Das
    Department of Molecular and Integrative Physiology, University of Kansas Medical Center, Ralph L Smith Research Center, Kansas City 66160 7338, USA
    Endocrinology 139:2905-15. 1998
    ..E2) and 4-hydroxyestradiol-17beta (4-OH-E2), a catechol metabolite of E2, on uterine expression of lactoferrin (LF) and progesterone receptor (PR). These genes are estrogen responsive in the mouse uterus...
  37. ncbi Oral lactoferrin for the prevention of sepsis and necrotizing enterocolitis in preterm infants
    Mohan P Venkatesh
    Pediatrics, Section of Neonatology, Baylor College of Medicine, 6621, Fannin, MC WT 6 104, Houston, Texas, USA, 77030
    Cochrane Database Syst Rev 5:CD007137. 2010
    BACKGROUND: Lactoferrin, a normal component of human colostrum, milk, tears and saliva can enhance host defence and may be effective in the prevention of sepsis and necrotizing enterocolitis (NEC) in preterm neonates...
  38. pmc Host iron binding proteins acting as niche indicators for Neisseria meningitidis
    Philip W Jordan
    The Bacterial Pathogenesis and Functional Genomics Group, The Sir William Dunn School of Pathology, University of Oxford, Oxford, United Kingdom
    PLoS ONE 4:e5198. 2009
    ..available iron sources differ, particularly the host iron-binding proteins haemoglobin, transferrin, and lactoferrin. This study compared the transcriptional responses of N...
  39. doi Effects of colostrum replacer supplemented with lactoferrin on the blood plasma immunoglobulin G concentration and intestinal absorption of xylose in the neonatal calf
    E C Shea
    Department of Animal and Nutritional Sciences, University of New Hampshire, Durham 03824, USA
    J Anim Sci 87:2047-54. 2009
    The objective of this experiment was to determine the effect of lactoferrin (Lf) supplementation of colostrum replacer (CR) fed as 1 or 2 doses on apparent efficiency of IgG absorption, serum IgG concentrations, and xylose absorption/..
  40. ncbi Binding of extracellular matrix proteins by animal strains of staphylococcal species
    I Styriak
    Department of Microbiology, Institute of Animal Physiology, Slovak Academy of Sciences, Kosice, Slovakia
    Vet Microbiol 67:99-112. 1999
    ..Bovine lactoferrin, human vitronectin, human fibronectin, heparin, human and bovine serum albumin were immobilized on latex beads ..
  41. doi A new chance of preventing winter diseases by the administration of synbiotic formulations
    Fabrizio Pregliasco
    Department of Public Health Microbiology Virology, Universita degli Studi di Milano, Milan, Italy Fabrizio
    J Clin Gastroenterol 42:S224-33. 2008
    ..containing 3 to 5 strains of Lactobacillus plantarum, Lactobacillus rhamnosus, and Bifidobacterium lactis, lactoferrin and prebiotics such as either FOS (short-chain fructooligosaccharides) or GOS (galactooligosaccharides)...
  42. ncbi Lactoferrin expression in the canine uterus during the estrous cycle and with pyometra
    K Kida
    Department of Advanced Pathobiology, Graduate School of Life and Environmental Sciences, Osaka Prefecture University, Osaka 599 8531, Japan
    Theriogenology 66:1325-33. 2006
    The expression of lactoferrin, a non-specific antimicrobial defence, in the canine uterus during the normal estrous cycle and in bitches with pyometra was examined...
  43. ncbi Lactoferrin-enhanced anoikis: a defense against neonatal necrotizing enterocolitis
    Michael P Sherman
    Division of Neonatology, School of Medicine, University of California, Surge I, Suite 1121, Davis, CA 95616, USA
    Med Hypotheses 65:478-82. 2005
    Enteral nutrition with human milk lowers the incidence of necrotizing enterocolitis in preterm human infants. Lactoferrin, the major whey protein in human milk, has many functions related to host defense against bacterial infection...
  44. doi Use and endocytosis of iron-containing proteins by Entamoeba histolytica trophozoites
    Fernando López-Soto
    Departamento de Biologia Celular, Centro de Investigacion y de Estudios Avanzados del IPN, Mexico, DF 07000, Mexico
    Infect Genet Evol 9:1038-50. 2009
    ..all organisms; in mammals, it is part of proteins such as haemoglobin, and it is captured by transferrin and lactoferrin. Transferrin is present in serum, and lactoferrin is secreted by the mucosa and by neutrophils at infection ..
  45. ncbi Utilization of lactoferrin to fight antibiotic-resistant mammary gland pathogens
    P Lacasse
    Agriculture and Agri Food Canada, Dairy and Swine Research and Development Centre, PO Box 90 STN Lennoxville, Sherbrooke, Quebec, Canada J1M 1Z3
    J Anim Sci 86:66-71. 2008
    ..b>Lactoferrin (Lf) is naturally produced by the mammary gland...
  46. doi Characterization of lactoferrin receptor on human spermatozoa
    Peng Wang
    Laboratory of Reproductive Medicine, Department of Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China
    Reprod Biomed Online 22:155-61. 2011
    b>Lactoferrin (LF) is abundant in human seminal plasma and on sperm surfaces. However, lactoferrin receptor (LFR) on human spermatozoa has not yet been reported...
  47. ncbi Characterization of the infection-responsive bovine lactoferrin promoter
    Jiamao Zheng
    Lactation and Mammary Gland Biology Group, Department of Animal Science, 213 Terrill Hall, University of Vermont, Burlington, VT 05405, USA
    Gene 353:107-17. 2005
    The concentration of lactoferrin in bovine milk is dramatically increased in response to infection. The high levels of lactoferrin may have a role in the prevention of microbial infection of the mammary gland...
  48. ncbi [The role of lactoferrin in the iron metabolism. Part II. Antimicrobial and antiinflammatory effect of lactoferrin by chelation of iron]
    Jolanta Artym
    Zakład Terapii Doświadczalnej Instytutu Immunologii i Terapii Doświadczalnej PAN im L Hirszfelda we Wrocławiu, 53 114 Wrocław
    Postepy Hig Med Dosw (Online) 64:604-16. 2010
    b>Lactoferrin (LF) is a glycoprotein widely distributed in mammalian organisms. It is synthesized by epithelial cells; hence it is present in secretions of mucous membranes...
  49. pmc Coadsorption of human milk lactoferrin into the dipalmitoylglycerolphosphatidylcholine phospholipid monolayer spread at the air/water interface
    Fausto Miano
    Società Industria Farmaceutica Italiana SpA, Lavinaio Catania, Italy
    Biophys J 92:1254-62. 2007
    The coadsorption of human milk lactoferrin into a spread monolayer of dipalmitoylglycerol phosphatidylcholine (DPPC) at the air/water interface has been studied by neutron reflection...
  50. ncbi Elevated free tear lactoferrin levels in leprosy are associated with Type 2 reactions
    Ebenezer Daniel
    Department of Ophthalmology, Schieffelin Leprosy Research and Training Center, Tamil Nadu, India
    Indian J Ophthalmol 52:51-6. 2004
    To determine the association of demographics, leprosy and ocular characteristics with altered levels of lactoferrin in the tears of normal subjects and leprosy patients, and to detect the presence of antibodies to lactoferrin in these ..
  51. ncbi The low-density lipoprotein receptor-related protein 1 is a mitogenic receptor for lactoferrin in osteoblastic cells
    Andrew Grey
    Department of Medicine, University of Auckland, Private Bag 92019, Auckland, New Zealand
    Mol Endocrinol 18:2268-78. 2004
    b>Lactoferrin induces osteoblast proliferation and survival in vitro and is anabolic to bone in vivo...
  52. ncbi Rapid purification of porcine colostral whey lactoferrin by affinity chromatography on single-stranded DNA-agarose. Characterization, amino acid composition and N-terminal amino acid sequence
    T W Hutchens
    USDA ARS Children s Nutrition Research Center, Department of Pediatries, Baylor College of Medicine, Houston 77030
    Biochim Biophys Acta 999:323-9. 1989
    We have determined that the major iron-binding and DNA-binding protein in porcine colostral whey is lactoferrin. This lactoferrin was purified to homogeneity in one chromatographic step using immobilized single-stranded DNA-agarose...
  53. doi Bovine lactoferrin supplementation for prevention of late-onset sepsis in very low-birth-weight neonates: a randomized trial
    Paolo Manzoni
    Neonatology and Neonatal Intensive Care Unit, S Anna Hospital, Azienda Ospedaliera Regina Margherita S Anna, C Spezia 60, 10126 Torino, Italy
    JAMA 302:1421-8. 2009
    ..Whether lactoferrin, a mammalian milk glycoprotein involved in innate immune host defenses, can reduce the incidence of sepsis is ..
  54. doi Bovine lactoferrin inhibits Japanese encephalitis virus by binding to heparan sulfate and receptor for low density lipoprotein
    Yu Jung Chien
    Graduate Institute of Veterinary Public Health, College of Veterinary Medicine, National Chung Hsing University, Taichung, Taiwan
    Virology 379:143-51. 2008
    b>Lactoferrin is a natural anti-microbial protein which affects Japanese encephalitis virus (JEV) activity...
  55. ncbi Anti-neutrophil cytoplasmic antibodies in patients with chronic liver diseases: prevalence, antigen specificity and predictive value for diagnosis of autoimmune liver disease. Swedish Internal Medicine Liver Club (SILK)
    S Lindgren
    Department of Medicine, University Hospital, Malmo, Sweden
    J Gastroenterol Hepatol 15:437-42. 2000
    ..As their predictive value for autoimmune liver disease remains unknown, we analysed the prevalence and antigen specificity of ANCA in patients with various chronic liver diseases (CLD)...
  56. ncbi A curcumin-based 1-week triple therapy for eradication of Helicobacter pylori infection: something to learn from failure?
    Francesco Di Mario
    Section of Gastroenterology, Department of Clinical Sciences, University of Parma, Italy
    Helicobacter 12:238-43. 2007
    ..N-acetylcysteine and lactoferrin with their respective mucolytic and antibacterial activities might also be effective in H...
  57. ncbi Noninvasive markers in the assessment of intestinal inflammation in inflammatory bowel diseases: performance of fecal lactoferrin, calprotectin, and PMN-elastase, CRP, and clinical indices
    Jost Langhorst
    Department of Internal and Integrative Medicine, Kliniken Essen Mitte, University of Duisburg Essen, Germany
    Am J Gastroenterol 103:162-9. 2008
    The aim of this study was to compare the performance of fecal lactoferrin (Lf), calprotectin (Cal), polymorphonuclear neutrophil elastase (PMN-e), as well as serum C-reactive protein (CRP) in patients with inflammatory bowel diseases (..
  58. doi Short communication: Antimicrobial effect of lactoferrin and its amidated and pepsin-digested derivatives against Salmonella Enteritidis and Pseudomonas fluorescens
    A del Olmo
    Departamento de Tecnologia de Alimentos, INIA, Carretera de la Coruña Km 7, Madrid, 28040 Spain
    J Dairy Sci 93:3965-9. 2010
    The antimicrobial effect of bovine lactoferrin (LF) and its amidated and pepsin-digested derivatives, at concentrations varying from 0...
  59. doi Glycosaminoglycans are not indispensable for the anti-herpes simplex virus type 2 activity of lactoferrin
    M Marchetti
    Department of Technology and Health, Istituto Superiore di Sanita, Viale Regina Elena 299, 00161 Rome, Italy
    Biochimie 91:155-9. 2009
    b>Lactoferrin has been recognized as a potent inhibitor of human herpetic viruses, such as herpes simplex type 1 (HSV-1) and 2 (HSV-2)...
  60. ncbi Activated lactoferrin and fluconazole synergism against Candida albicans and Candida glabrata vaginal isolates
    A Satyanarayan Naidu
    N terminus Research Laboratory, Pomona, CA 91768, USA
    J Reprod Med 49:800-7. 2004
    To evaluate the fungistatic activity of activated lactoferrin (ALF), fluconazole (FCN) individually and in combination against Candida vaginal isolates as well as to measure the time to recovery from the fungistatic effects after ..
  61. ncbi Variation in antimicrobial activity of lactoferricin-derived peptides explained by structure modelling
    Sebastien Farnaud
    Randall Division of Cell and Molecular Biophysics, King s College London, New Hunt s House, Guy s Campus, St Thomas Street, London SE1 1UL, UK
    FEMS Microbiol Lett 238:221-6. 2004
    Antimicrobial peptides bovine lactoferricin (LfcinB) and human lactoferricin (LfcinH) are produced from the respective lactoferrin, but are more active than their precursors...
  62. pmc Recognition of lactoferrin and aminopeptidase M-modified lactoferrin by the liver: involvement of proteoglycans and the remnant receptor
    G J Ziere
    Division of Biopharmaceutics, Leiden Amsterdam Center for Drug Research, University of Leiden, Sylvius Laboratory, The Netherlands
    Biochem J 313:289-95. 1996
    1. Lactoferrin and aminopeptidase M-modified lactoferrin (APM-lactoferrin; which lacks its 14 N-terminal amino acids) inhibit the liver uptake of lipoprotein remnant...
  63. ncbi Biochemical analysis of lactoferrin receptors in the Neisseriaceae: identification of a second bacterial lactoferrin receptor protein
    R A Bonnah
    Department of Microbiology and Infectious Diseases, University of Calgary, Alberta, Canada
    Microb Pathog 19:285-97. 1995
    ..In contrast, bacterial lactoferrin receptors have only been described for human pathogens in the family Neisseriaceae, and were believed to ..
  64. ncbi [Muramidase and lactoferrin in adenoidal hypertrophies, hypertrophic and chronic infected tonsil tissue--a quantitative analysis]
    M Schwaab
    Universitätsklinik für Hals Nasen Ohrenheilkunde und Kopf und Halschirurgie, Ruhr Universitat Bochum
    Laryngorhinootologie 84:660-4. 2005
    Muramidase and lactoferrin are important components of the antimicrobial defense system. Muramidase has the ability of opsonization and immunopotentiation and therefore a close relation to the lymphatic tissue...
  65. ncbi Effect of dietary lactoferrin on the immune functions and serum iron level of weanling piglets
    T Shan
    Institute of Feed Science, Zhejiang University, The Key Laboratory of Molecular Animal Nutrition, Ministry of Education, No 164 Qiutao North Road, Hangzhou 310029, PR China
    J Anim Sci 85:2140-6. 2007
    ..female pigs (Duroc x Landrace x Yorkshire) were used in a 30-d growth experiment to investigate the effect of lactoferrin (LF) on growth performance, immune function, and serum iron concentrations...
  66. ncbi Lactoferrin given in food facilitates dermatophytosis cure in guinea pig models
    H Wakabayashi
    Nutritional Science Laboratory, Morinaga Milk Industry Co Ltd, Zama, Kanagawa 228 8583, Japan
    J Antimicrob Chemother 46:595-602. 2000
    ..Human and bovine lactoferrin, and a bovine lactoferrin-derived peptide, lactoferricin B, showed in vitro antifungal activity that was dependent on the test strain and medium used...
  67. ncbi Effect of lactoferrin on Helicobacter felis induced gastritis
    Elizabeth J Dial
    Department of Integrative Biology and Pharmacology, University of Texas Health Science Center, Houston Medical School, 77225, USA
    Biochem Cell Biol 80:113-7. 2002
    b>Lactoferrin possesses antibiotic, antiinflammatory, and immune-modulating properties that may be active against the gastritis-, ulcer- and cancer-inducing bacterium Helicobacter pylori...
  68. doi The lactoferrin receptor complex in Gram negative bacteria
    Amanda J Beddek
    Department of Microbiology and Infectious Diseases, University of Calgary, Rm G503A Health Sciences Center, 3330 Hospital Drive N W, Calgary, AB, Canada T2N 4N1
    Biometals 23:377-86. 2010
    ..is also present in high concentrations at sites of inflammation where the cationic anti-microbial peptide lactoferricin is produced by proteolysis of lactoferrin...
  69. ncbi Lactoferrin sequestration and its contribution to iron-deficiency anemia in Helicobacter pylori-infected gastric mucosa
    Yon Ho Choe
    Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
    J Gastroenterol Hepatol 18:980-5. 2003
    It is known that lactoferrin serves as a source of iron for Helicobacter pylori in gastric mucosa. The present study was undertaken to investigate the relationship between lactoferrin and H...
  70. ncbi The synergistic effect of nisin and lactoferrin on the inhibition of Listeria monocytogenes and Escherichia coli O157:H7
    C A Murdock
    Rutgers, The State University of New Jersey, New Brunswick, New Jersey 08901 8520, USA
    Lett Appl Microbiol 44:255-61. 2007
    The goal of this study was to determine whether nisin and lactoferrin would act synergistically to inhibit the growth of Listeria monocytogenes and Escherichia coli O157:H7.
  71. ncbi Comparative analysis of the transferrin and lactoferrin binding proteins in the family Neisseriaceae
    A B Schryvers
    Department of Microbiology and Infectious Diseases, University of Calgary, Alta, Canada
    Can J Microbiol 35:409-15. 1989
    Intact cells of several bacterial species were tested for their ability to bind human transferrin and lactoferrin by a solid-phase binding assay using horseradish peroxidase conjugated transferrin and lactoferrin...
  72. pmc Lactoferrin binding to the rat asialoglycoprotein receptor requires the receptor's lectin properties
    D D McAbee
    Department of Chemistry and Biochemistry, California State University, Long Beach 90840 3903, USA
    Biochem J 348:113-7. 2000
    b>Lactoferrin binds to rat hepatic lectin 1 (RHL1), the major subunit of the asialoglycoprotein (ASGP) receptor, with high affinity, by a galactose-independent mechanism...
  73. ncbi Characterization of estrogen-responsive mouse lactoferrin promoter
    Y H Liu
    Developmental Endocrinology and Pharmacology Section, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709
    J Biol Chem 266:21880-5. 1991
    Mouse lactoferrin is expressed in a variety of tissues under different types of control...
  74. pmc Lactoferrin protects against development of hepatitis caused by sensitization of Kupffer cells by lipopolysaccharide
    M Yamaguchi
    Department of Nutritional Research, Nutrition Science Institute, Meiji Dairies Corporation, Odawara, Kanagawa, 250 0862 Japan
    Clin Diagn Lab Immunol 8:1234-9. 2001
    ..05 microg/g of body weight) 7 days after being primed with zymosan. Recombinant human lactoferrin (250 microg/g of body weight), intravenously administered 1 day before the injection of LPS, significantly ..
  75. ncbi Methoxychlor stimulates the mouse lactoferrin gene promoter through a GC-rich element
    Zhiping Zhang
    Gene Regulation Section, Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Biochem Cell Biol 80:23-6. 2002
    The lactoferrin gene in the mouse uterus is a target gene for natural estrogens and xenoestrogens. One of the xenoestrogens is methyoxychlor, an insecticide that displays both estrogenic and antiandrogenic activities...
  76. doi Bactericidal effect of lactoferrin and lactoferrin chimera against halophilic Vibrio parahaemolyticus
    Nidia León-Sicairos
    Departamento de Investigacion, Hospital Pediátrico de Sinaloa, Blvd Constitución S N, Culiacan, Sin 80200, Mexico
    Biochimie 91:133-40. 2009
    ..Whereas both peptides lactoferricin (17-30) and lactoferrampin (265-284) did not have bactericidal activity, 40 microM of lactoferrin chimera (a ..
  77. doi Efficacy and tolerability of oral bovine lactoferrin compared to ferrous sulfate in pregnant women with iron deficiency anemia: a prospective controlled randomized study
    Carmine Nappi
    Department of Gynecology and Obstetrics, University of Naples Federico II, Via S Pansini 5, Naples, Italy
    Acta Obstet Gynecol Scand 88:1031-5. 2009
    To compare the effects of bovine lactoferrin with ferrous sulfate on iron nutritional status and to evaluate their tolerability in 100 pregnant women with iron deficiency anemia.
  78. ncbi A prospective study of faecal calprotectin and lactoferrin in the monitoring of acute radiation proctitis in prostate cancer treatment
    Andrea Hille
    Department of Radiotherapy and Radio Oncology, University of Gottingen, Gottingen, Germany
    Scand J Gastroenterol 43:52-8. 2008
    ..Acute radiation proctitis is a relevant complication of pelvic radiation. The purpose of this study was to investigate two markers of gut inflammation as non-invasive diagnostic tools to evaluate acute radiation proctitis...
  79. ncbi Activated lactoferrin's ability to inhibit Candida growth and block yeast adhesion to the vaginal epithelial monolayer
    A Satyanarayan Naidu
    N terminus Research Laboratory, USA
    J Reprod Med 49:859-66. 2004
    To study in vitro growth-inhibitory effects of activated lactoferrin (ALF) against vaginal isolates of Candida species and to measure the ability of ALF to block interactions of Candida albicans and Candida glabrata to the vaginal ..
  80. ncbi Recombinant human lactoferrin treatment for global health issues: iron deficiency and acute diarrhea
    Delia R Bethell
    Ventria Bioscience, 4110 N Freeway Boulevard, Sacramento, California 95834, USA
    Biometals 17:337-42. 2004
    ..Recombinant human lactoferrin (rhLF), expressed and extracted from rice seed, is being evaluated by Ventria Bioscience for use as a dietary ..
  81. ncbi Recombinant human lactoferrin has a potential to suppresses uterine cervical ripening in preterm delivery in animal model
    K Yakuwa
    Department of Obstetrics and Gynecology, Showa University School of Medicine, 1 5 8 Hatanodai, Shinagawa ku, Tokyo 142 8666, Japan
    Arch Gynecol Obstet 275:331-4. 2007
    To investigate the effect of recombinant human lactoferrin (rhLF) on cervical ripening using a rabbit model in which preterm labor was induced by bacterial endotoxin lipopolysaccharide (LPS).
  82. ncbi Expression of bovine lactoferrin and lactoferrin N-lobe by recombinant baculovirus and its antimicrobial activity against Prototheca zopfii
    Tetsuya Tanaka
    Graduate School of Agriculture, Hokkaido University, Sapporo, Japan
    Biochem Cell Biol 81:349-54. 2003
    b>Lactoferrin (LF) is a multifunctional, iron-binding glycoprotein found in secretory fluids of mammals...
  83. doi Human recombinant lactoferrin acts synergistically with antimicrobials commonly used in neonatal practice against coagulase-negative staphylococci and Candida albicans causing neonatal sepsis
    Mohan Pammi Venkatesh
    Baylor College of Medicine and Texas Children s Hospital, 6621 Fannin, MC WT 6 104, Houston, TX 77030, USA
    J Med Microbiol 57:1113-21. 2008
    ..Coagulase-negative staphylococci (CoNS) and Candida frequently cause neonatal sepsis at >72 h of age. Lactoferrin, which is present in human milk, is a component of innate immunity and has broad-spectrum antimicrobial ..
  84. ncbi Quadruple therapy with lactoferrin for Helicobacter pylori eradication: a randomised, multicentre study
    A Zullo
    Gastroenterology and Digestive Endoscopy, Nuovo Regina Margherita Hospital, Rome, Italy
    Dig Liver Dis 37:496-500. 2005
    Helicobacter pylori eradication rate with standard triple therapies is decreasing. Recently, lactoferrin administration has been shown to significantly increase the cure rate of 7-day rabeprazole, clarithromycin and tinidazole triple ..
  85. doi Microbicidal effect of the lactoferrin peptides lactoferricin17-30, lactoferrampin265-284, and lactoferrin chimera on the parasite Entamoeba histolytica
    Fernando López-Soto
    Laboratorio de Bioquímica de Proteínas, Departamento de Medicina y Ciencias de la Salud, Universidad de Sonora, Blvd Luis Encinas y Rosales, Col Centro, 83000 Hermosillo, Sonora, Mexico
    Biometals 23:563-8. 2010
    ..Recently, lactoferrin and lactoferricin B have been shown to be amoebicidal in axenic cultures...
  86. ncbi Effect of lactoferrin on the growth performance, intestinal morphology, and expression of PR-39 and protegrin-1 genes in weaned piglets
    Y Wang
    Institute of Feed Science, Zhejiang University, The Key Laboratory of Molecular Animal Nutrition, Ministry of Education, No 164 Qiutao North Road, Hangzhou 310029, P R China
    J Anim Sci 84:2636-41. 2006
    ..female pigs (Duroc x Landrace x Yorkshire) were used in a 15-d growth experiment to investigate the effect of lactoferrin on growth performance, intestinal morphology, and expression of PR-39 and protegrin-1 genes...
  87. doi Attenuated phrenic long-term facilitation in orexin neuron-ablated mice
    Shinichi Toyama
    Department of Molecular and Integrative Physiology, Chiba University Graduate School of Medicine, Chiba, Japan
    Respir Physiol Neurobiol 168:295-302. 2009
    ..This study also showed, for the first time, phrenic LTF following IH in WT mice. Characteristics of phrenic and ventilatory LTF in mice were similar to those in rats...
  88. pmc 5-HT evokes sensory long-term facilitation of rodent carotid body via activation of NADPH oxidase
    Ying Jie Peng
    Department of Physiology and Biophysics, School of Medicine, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44019, USA
    J Physiol 576:289-95. 2006
    ....
  89. ncbi Intelectin: a novel lipid raft-associated protein in the enterocyte brush border
    Uta Wrackmeyer
    Department of Medical Biochemistry and Genetics, Panum Institute, University of Copenhagen, Blegdamsvej 3, DK 2200 Copenhagen N, Denmark
    Biochemistry 45:9188-97. 2006
    ..In addition, it is structurally identical to the intestinal lactoferrin receptor known to reside in the enterocyte brush border...
  90. ncbi Double esterase staining and other neutrophilic granule abnormalities in 237 patients with the myelodysplastic syndrome studied by the cancer and leukemia group B
    M T Elghetany
    University of Texas Medical Branch, Galveston, TX, USA
    Acta Haematol 100:13-6. 1998
    ..were examined cytochemically and immunocytochemically for myeloperoxidase activity and antigen elastase, lactoferrin and CD15 granule-membrane glycoproteins...
  91. pmc Phylogenetic analyses uncover a novel clade of transferrin in nonmammalian vertebrates
    Hirzahida Mohd-Padil
    School of Biosciences and Biotechnology, Faculty of Science Technology, Universiti Kebangsaan Malaysia, Selangor, Malaysia
    Mol Biol Evol 30:894-905. 2013
    ..transferrin members have diversified into distinct subfamilies including serotransferrin, ovotransferrin, lactoferrin, melanotransferrin, the inhibitor of carbonic anhydrase, pacifastin, and the major yolk protein in sea urchin...
  92. doi Nitric oxide is necessary for long-term facilitation of synaptic responses and for development of context memory in terrestrial snails
    T A Korshunova
    Koltzov Institute of Developmental Biology, Russian Academy of Sciences, Vavilova 26 Street, 119334 Moscow, Russian Federation Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, Butlerova 5a Street, 117485 Moscow, Russian Federation Electronic address
    Neuroscience 266:127-35. 2014
    ..This suggests that NO influences the behavior via regulation of synaptic plasticity. ..
  93. doi Longitudinal analysis of protein glycosylation and β-casein phosphorylation in term and preterm human milk during the first 2 months of lactation
    Claire E Molinari
    School of Chemistry and Biochemistry, The University of Western Australia, M310, 35 Stirling Highway, Crawley, WA 6009, Australia
    Br J Nutr 110:105-15. 2013
    ..Using gel electrophoresis, the relative concentration and glycosylation status of lactoferrin, secretory Ig A, β-casein, α-lactalbumin, serum albumin, bile salt-stimulated lipase, xanthine oxidoreductase,..
  94. ncbi The interaction between saliva and Actinobacillus actinomycetemcomitans influenced by the zeta potential
    J Groenink
    Dept of Oral Biology, Academic Centre for Dentistry Amsterdam ACTA, Amsterdam, The Netherlands
    Antonie Van Leeuwenhoek 73:279-88. 1998
    ..actinomycetemcomitans. Under these conditions, binding of the low-molecular-weight salivary mucin, lactoferrin, and S-IgA was confirmed using salivary samples and purified salivary fractions in liquid-phase and in ELISA...
  95. pmc Persistent long-term facilitation at an identified synapse becomes labile with activation of short-term heterosynaptic plasticity
    Jiang Yuan Hu
    Department of Neuroscience, Columbia University College of Physicians and Surgeons, and New York State Psychiatric Institute, New York, New York 10032
    J Neurosci 34:4776-85. 2014
    ..Activity-selective induction of a labile state at synapses expressing persistent plasticity may facilitate the development of therapies for reversing inappropriate memories. ..
  96. ncbi Modulation of neutrophil and inflammation markers in chronic obstructive pulmonary disease by short-term azithromycin treatment
    Michael J Parnham
    PLIVA Research Institute Ltd, Prilaz baruna Filipovica 29, HR 10 000 Zagreb, Croatia
    Eur J Pharmacol 517:132-43. 2005
    ..platelet counts, serum acute phase protein (including C reactive protein) and soluble E-selectin and blood neutrophil lactoferrin concentrations and a transient decrease in serum interleukin-8 were observed...
  97. doi The impact of the Maillard reaction on the in vitro proteolytic breakdown of bovine lactoferrin in adults and infants
    Alice M Moscovici
    Department of Biotechnology and Food Engineering, Technion Israel Institute of Technology, Haifa 32000, Israel
    Food Funct 5:1898-908. 2014
    ..fate of Maillard reaction products (MRPs) still exist, especially regarding bioactive proteins such as lactoferrin (LF)...
  98. doi Effect of lactoferrin-impregnated porous poly(lactide-co-glycolide) (PLGA) microspheres on osteogenic differentiation of rabbit adipose-derived stem cells (rADSCs)
    Sung Eun Kim
    Department of Orthopedic Surgery and Rare Diseases Institute, Korea University Medical College, Guro Hospital, 80, Guro Dong, Guro Gu, Seoul 152 703, Republic of Korea
    Colloids Surf B Biointerfaces 122:457-64. 2014
    The aim of this study was to develop lactoferrin (LF)-impregnated porous poly(lactide-co-glycolide) (PLGA) microspheres (PMs) to induce osteogenic differentiation of rabbit adipose-derived stem cells (rADSCs)...
  99. doi Protein functionalized tramadol-loaded PLGA nanoparticles: preparation, optimization, stability and pharmacodynamic studies
    Jigar Lalani
    Pharmacy Department, Faculty of Technology and Engineering, Drug Delivery Laboratory, TIFAC Centre of Relevance and Excellence in NDDS, G H Patel Building of Pharmacy, The Maharaja Sayajirao University of Baroda, Vadodara, India
    Drug Dev Ind Pharm 39:854-64. 2013
    ..This can be overcome by anchoring endogenous ligand like Transferrin (Tf) and Lactoferrin (Lf) on the surface of NPs, allowing efficient brain delivery via receptor-mediated endocytosis...
  100. ncbi Bactericidal domain of lactoferrin: detection, quantitation, and characterization of lactoferricin in serum by SELDI affinity mass spectrometry
    H Kuwata
    Department of Food Science and Technology, University of California, Davis 95616, USA
    Biochem Biophys Res Commun 245:764-73. 1998
    b>Lactoferricin is a bioactive peptide fragment (3196 Da) derived from lactoferrin (80 kDa) that contains the bactericidal domain and the lymphocyte receptor-binding domain of lactoferrin...
  101. ncbi Lipid raft organization and function in the small intestinal brush border
    E M Danielsen
    Department of Cellular and Molecular Medicine, The Panum Institute, University of Copenhagen, Copenhagen, Denmark
    J Physiol Biochem 64:377-82. 2008
    ..complexes are further stabilized by intelectin, a 35 kDa trimeric lectin that also functions as an intestinal lactoferrin receptor...

Research Grants64

  1. Recombinant Lactoferrin and Necrotizing Enterocolitis
    Karel Petrak; Fiscal Year: 2004
    This feasibility study is based on our hypothesis that recombinant human lactoferrin [rhLF] can prevent or reduce severity of necrotizing enterocolitis [NEC]. NEC is mainly a disease of very low birth weight [VLBW] human infants...
  2. Randomonized controlled trial-lactoferrin prevention of diarrhea in children
    THOMAS GEORGE CLEARY; Fiscal Year: 2010
    ..The proposed study is meant to begin addressing this important gap by a clinical trial of lactoferrin supplementation in previously weaned children...
  3. Lactoferrin for prevention of sepsis in infants
    Theresa J Ochoa; Fiscal Year: 2013
    ..We hypothesize that lactoferrin, an iron binding protein present in mammalian milk, is the major factor responsible for this effect due to its ..
  4. Iron Acquisition by Mycobacterium tuberculosis Within Phagocytes
    Bradley E Britigan; Fiscal Year: 2013
    ..tb growth. In vivo, most extracellular Fe is chelated to transferrin (TF) and lactoferrin (LF), decreasing microbial access to Fe. We find that M...
  5. IRON ACQUISITION IN BORDETELLA PERTUSSIS
    SANDRA KAY ARMSTRONG; Fiscal Year: 2013
    ..means by which Bordetella cells use host neuroendocrine stress hormones to obtain the iron from transferrin and lactoferrin. PUBLIC HEALTH RELEVANCE: Nearly all bacteria require iron for growth and pathogenic bacteria must be able to ..
  6. Iron acquisition mechanisms utilized by Neisseria gonorrhoeae
    Cynthia Nau Cornelissen; Fiscal Year: 2010
    ..iron from a variety of host-specific sources, including from the iron-binding glycoproteins, transferrin and lactoferrin. Iron transport from these iron-binding proteins is accomplished by an integral, outer membrane transporter, ..
  7. Lactoferrin for Immunomodulation of Systemic Inflammatory Response Syndrome
    Marian L Kruzel; Fiscal Year: 2011
    ..a biologic therapeutic to treat systemic inflammatory response syndrome (SIRS) using a novel human recombinant lactoferrin that contains "humanized" glycosylation patterns...
  8. Formula with antimicrobials to decrease infant mortality
    Koteswara Chintalacharuvu; Fiscal Year: 2006
    ..S-IgA, lactoferrin and lysozyme in breast milk are the major antimicrobial factors...
  9. Lactoferrin Enhances Growth and Reduces Nosocomial Infection in Preterm Infants
    Karel Petrak; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): This project aims to develop talactoferrin (TLF, recombinant human lactoferrin) as a therapeutic agent to treat prematurely born neonates...
  10. Metabolomic Analysis as a Tool to Understanding the Use of Novel Therapeutics in
    MARY CLOUD BOSWORTH AMMONS; Fiscal Year: 2013
    ..metabolic patterns and that the biofilms are especially sensitive to iron deprivation by the immune molecule lactoferrin, document that exposure to P...
  11. X RAY STRUCTURAL STUDIES OF LACTOFERRIN
    Edward Baker; Fiscal Year: 2000
    DESCRIPTION (Adapted from applicant's abstract): Lactoferrin is a prominent iron-binding protein from human milk, other secretions, and leukocytes and possesses a wide variety of established or proposed biological activities...
  12. Human Lactoferrin in Acetaminophen Overdose-Induced Liver Failure
    Cynthia Ju; Fiscal Year: 2012
    ..In our preliminary study with milk- derived lactoferrin, we demonstrate that the lactoferrin has a profound hepato-protective effect in a murine model of AILI...
  13. Role of C/EBPepsilon in myeloid differentiation
    Stephanie Halene; Fiscal Year: 2010
    ..The appearance of the secondary granule proteins (SGP) lactoferrin (LF), transcobalamin I (TCI), neutrophil collagenase (NC) and neutrophil gelatinase (NG) marks the commitment ..
  14. BACTERICIDAL ACTIVITY OF LACTOFERRIN ON ORAL FLORA
    Roland Arnold; Fiscal Year: 1993
    b>Lactoferrin (LF), a principal glycoprotein component of secretions that bathe mucosal surfaces and of the specific granules of neutrophils (PMN), is capable of high affinity coordinate binding of Fe3+ and CO3 2- It has been shown to have ..
  15. PATHOPHYSIOLOGY OF THE LACTOFERRINS
    PHILIP FURMANSKI; Fiscal Year: 1999
    DESCRIPTION: (adapted from the investigator's abstract) Lactoferrin (Lf) is the most avid Fe-binding protein in human milk and other epithelial secretions and is the major constituent of the specific granules of neutrophils...
  16. Determinants of Treatment Response in Cancers
    PHILIP FURMANSKI; Fiscal Year: 2003
    b>Lactoferrin (Lf), a multifunctional molecule first identified as a major constituent of human milk, has become the subject of intensive and widespread study...
  17. Expression of Human Transferrin in Rice Grain
    Deshui Zhang; Fiscal Year: 2009
    ..Ventria Bioscience already has produced the human lactoferrin, a close relative to human transferrin, in rice grains on large scale and at low lost...
  18. Targeting Pneumococcal Virulence Factors in Otitis Media
    Honggao Yan; Fiscal Year: 2012
    ..to bind human complement factor H (FH) and the ectodomain of pIgR and the ability of PspA to bind apo- and holo-lactoferrin (LF) and to inhibit complement deposition...
  19. Effect of Lactoferrin on Alcohol-Induced Dysbiosis and Gut Barrier Dysfunction
    Cynthia Ju; Fiscal Year: 2013
    ..Our preliminary studies demonstrate that lactoferrin (LF) suppresses alcohol-induced gut hyper-permeability...
  20. Injectable Anabolic Biomaterials for Bone Regeneration
    LAKSHMI SREEDHARAN NAIR; Fiscal Year: 2013
    ..The aim of the proposed study is to evaluate the efficacy of an injectable biomaterial based on lactoferrin as an artificial microenvironment to increase the survival and osteogenic activity of encapsulated rat ..
  21. Female Genital Innate Immune Response to Vaginal Microbiota
    Caroline M Mitchell; Fiscal Year: 2013
    ..of antimicrobial peptides(beta-defensins, cathelicidin, secretory leukocyte protease inhibitor[SLPI], lactoferrin);2) that some individuals are more vulnerable to colonization due to low baseline levels of those antimicrobial ..
  22. PspA: A Potential Pneumococcal Vaccine Component
    David E Briles; Fiscal Year: 2012
    ..PspA also keeps apolactoferrin from killing Sp by neutralizing lactoferrin and its cationic peptide lactoferricin. Ab to PspA prevents the PspA-lactoferrin interaction and, thus, enhances apolactoferrin's ability to ..
  23. Microbiomes and Inflammation in Chronic Fatigue Syndrome
    RUTH EMILY LEY; Fiscal Year: 2013
    ..The amount of lactoferrin in stool samples will be determined as a measure of inflammation and bacterial endotoxin as an indication of ..
  24. Epithelial PLUNC as a determinant of Airway Mucosal Antimicrobial Activity
    YUANPU PETER DI; Fiscal Year: 2012
    ..ducts and submucosal glands, sites that express high levels of other host defense proteins such as lysozyme and lactoferrin. PLUNC is abundant in airway fluid of normal individuals and our preliminary results demonstrate that it ..
  25. Evaluation of Recombinant Human Lactoferrin as an Osteogenic Biomaterial
    Ashley A Amini; Fiscal Year: 2013
    ..b>Lactoferrin (LF), a multifunctional "moonlighting" glycoprotein, is also a potent anabolic effector of the skeleton...
  26. Clinical Research in HSV Infections
    Anna Wald; Fiscal Year: 2013
    ..mediators of inflammation, such as secretory leukocyte protease inhibitor, human neutrophil peptides 1-3 and lactoferrin,...
  27. Probiotics to Improve Outcomes of Clostridium difficile
    Nasia Safdar; Fiscal Year: 2013
    ..rhamnosus HN001, when compared with placebo, will reduce CDI recurrence, fecal lactoferrin levels, and quantity of C. difficile toxin while improving functional status...
  28. Functions of Lactoferrin Polymorphisms in an Oral Infection
    Kabilan Velliyagounder; Fiscal Year: 2011
    ..We recently have identified two new polymorphisms of the lactoferrin (Lf) gene that are involved in LAP...
  29. Lactoferrin as an Adjuvant for Cellular Immunity
    Jeffrey K Actor; Fiscal Year: 2010
    ..Regarding AIM III: the Aim III to investigate the systemic effects of the recombinant human lactoferrin using pre-IND, repeat dose toxicology protocols in two species (rat and dog) will be eliminated from the study...
  30. Innate Resistance to Mucosal HSV Infection in Humans
    Christine M Posavad; Fiscal Year: 2010
    ..and proteins in the mucosal samples with a focus on defensins, secretory leukocyte protease inhibitor (SLPI), lactoferrin and lysozyme, mediators linked to defense against HSV infection...
  31. Lactoferrin for the prevention of antibiotic-associated diarrhea in adult
    Ning Huang; Fiscal Year: 2012
    ..in vitro and preliminary in vivo studies lead us to hypothesize that oral administration of recombinant human lactoferrin as a medical food might be able to prevent and reduce antibiotic associated diarrhea in adults...
  32. ANTIMICROBIAL EFFECT OF PEROXIDASE IN LEUKOCYTES
    SEYMOUR KLEBANOFF; Fiscal Year: 1999
    ..The binding of the released iron by lactoferrin will be investigated since this iron-binding protein is present in neutrophil granules and may serve as a ..
  33. A TRANSCRIPTIONAL PROGRAM REGULATING MYELOPOIESIS
    Alan Friedman; Fiscal Year: 2004
    ..32D cl3 myeloid cells were developed expressing C/EBPa-ER or PU.1-ER. Activation of C/EBPa-ER increased MPO, lactoferrin, and G-CSF receptor mRNA expression and induced a neutrophilic morphology and a G1 cell cycle arrest...
  34. Structure/function studies of lactoferrin as a protease
    Andrew Plaut; Fiscal Year: 2005
    DESCRIPTION: We have recently discovered that human lactoferrin, a member of the lactotransferrin family of iron binding proteins, has proteolytic activity...
  35. APOE3 AND APOE4 EFFECTS ON CELLULAR PATHOBIOLOGY
    ROBERT PITAS; Fiscal Year: 1999
    ..the apoE isoforms will be explored using: neurons from LDL receptor knockout animals; competition studies with lactoferrin and the 39-kDa protein; and mutants of apoE (apoE2, apoE(Arg142 yieldsCys), apoE Leiden) with various degrees ..
  36. CDP/CUT AND MYELOID DIFFERENTIATION
    Nancy Berliner; Fiscal Year: 2001
    ..We have identified a region within the human lactoferrin (LF) gene promoter which confers a silencing effect on the expression of reporter gene plasmids in LF non-..
  37. CRYSTALLOGRAPHIC STUDIES OF NEISSERIA FE BINDING PROTEIN
    Duncan McRee; Fiscal Year: 1999
    ..Increasing evidence indicates that FBP shares a common fold and Fe-binding mechanism with lactoferrin, transferrin and bacterial periplasmic binding proteins...
  38. Iron acquisition systems in Neisseria gonorrhoeae
    CYNTHIA CORNELISSEN; Fiscal Year: 2007
    ..Although mechanisms for utilization of host iron-binding proteins, including transferrin and lactoferrin, have been most thoroughly characterized, expression of these receptors is not required for growth of the ..
  39. CASE CONTROL/STUDY OF PARKINSONS DISEASE IN THE ELDERLY
    Richard Mayeux; Fiscal Year: 1999
    ..Iron accumulates in the substantia nigra in IPD and lactoferrin receptors are increased whereas ferritin concentrations are reduced...
  40. INVESTIGATIONS OF THE BIOCHEMISTRY OF VANADIUM
    Alison Butler; Fiscal Year: 1992
    ..the naturally occurring V-bromoperoxidase and V substituted derivatives of transferrin, lactoferrin, ovotransferrin, carboxypeptidase A, carbonic anhydrase B, thermolysin, bleomycin, etc), and to examine the ..
  41. HOST DEFENSE FACTORS IN ORAL ECOLOGY
    JOEL RUDNEY; Fiscal Year: 1991
    Saliva contains a number of proteins which display antinicrobial activity in vitro. These include lysozyme (Lz), lactoferrin (Lf), salivary peroxidase (Spx), secretory immunoglobulin A (sIgA), the mucin glycoproteins (MG1 and MG2), and ..
  42. MONOCYTE/MACROPHAGE FREE RADICAL BIOLOGY ASSESSED BY EPR
    Bradley Britigan; Fiscal Year: 1993
    ..Even with iron supplementation, PMN lactoferrin and myeloperoxidase (MPO) release inhibited OH generation...
  43. Adenovirus Modulation of Lacrimal Gland Function
    SARAH HAMM ALVAREZ; Fiscal Year: 2005
    ..acinar cells of the lacrimal gland is the production and release of a variety of proteins including hormones, lactoferrin and lysosomal hydrolases into tear fluid...
  44. Use of recombinant human lactoferrin for wounds by stimulating cell growth
    Ning Huang; Fiscal Year: 2006
    ..We propose to use lactoferrin (LF) as a novel wound healing agent based on its ability to promote cell growth and its antimicrobial ..
  45. REGULATORY ROLES OF LACTOFERRIN IN HEMOSTASIS
    Haifeng Wu; Fiscal Year: 2003
    b>Lactoferrin is a prominent component of neutrophil secondary granules and can be released when neutrophils are activated. The concentration of lactoferrin in blood has been demonstrated to be increased in certain inflammatory diseases...
  46. NATURE OF INHIBITORS OF HIV IN HUMAN SECRETORY FLUIDS
    JOSEPH KINKADE; Fiscal Year: 1992
    ..saliva, parotid saliva, and submandibular/sublingual saliva) and of a number of purified secretory components (lactoferrin, IgA, lactoferrin-IgA complexes, lysozyme, peroxidase, agglutinins and secretory leukocyte protease inhibitor) ..
  47. Treatment of Sepsis using Recombinant Human Lactoferrin
    Karel Petrak; Fiscal Year: 2006
    ..b>Lactoferrin has been shown to provide protection in several models of sepsis...
  48. LACTOFERRIN AND MUCOSAL IMMUNITY
    Larry Thomas; Fiscal Year: 2001
    DESCRIPTION (Adapted from applicant's abstract): The important role of lactoferrin in innate mucosal immunity is well described...
  49. NEUTROPHIL INTERACTIONS WITH BACTEROIDES GINGIVALIS
    Christopher Cutler; Fiscal Year: 1991
    ..gingivalis by neurtophils will be determined and may involve myeloperoxidase (MPO), lactoferrin (LF), H202, hydroxy radical, singlet oxygen and superoxide production, and may occur intracellularly and ..
  50. Effects of Tobacco Smoke on Airway Bactericidal Activity
    Yuan Pu Di; Fiscal Year: 2004
    ..is specifically expressed in serous cells of submucosal glands where bactericidal proteins such as lysozyme and lactoferrin are secreted...
  51. PREVENTION/TREATMENT OF H. PYLORI WITH LACTOFERRIN
    BRUCE SCHRODER; Fiscal Year: 2001
    ..pylori). Preliminary research has found that bovine lactoferrin, a native antibiotic in bovine milk, is inhibitory to the growth of H...
  52. Lactoferrin as an Adjuvant for Cellular Immunity
    Jeffrey Actor; Fiscal Year: 2002
    ..We will specifically address the efficacy of Lactoferrin as an adjuvant to augment efficacy of BCG vaccination to subsequent challenge with virulent Mycobacterium ..
  53. Structure of Surface Antigens of S. Pneumoniae
    Debasish Chattopadhyay; Fiscal Year: 2005
    ..PspA inhibits killing of pneumococci by lactoferrin by binding to it...
  54. DIAGNOSIS OF INFLAMMATORY DIARRHEA
    ROBERT CARMAN; Fiscal Year: 1992
    ..The following project will evaluate assays designed to detect lactoferrin released from leukocytes in fecal specimens from patients with inflammatory diarrhea...
  55. Lactoferrin in Primate and Mouse Models of Asthma
    Atul Varadhachary; Fiscal Year: 2004
    ..purpose of this research is to extend work to determine the efficacy of orally administered recombinant human lactoferrin (rhLF) in an established primate model of asthma...
  56. ANALYSIS OF M CATARRHLIS RECEPTORS AS VACCINE ANTIGENS
    ANTHONY CAMPAGNARI; Fiscal Year: 2003
    ..We have reported studies demonstrating that M. catarrhalis can obtain iron from human transferrin and lactoferrin for in vitro growth, an the absence of any detectable siderophore specific proteins on the bacterial surface...
  57. GENERATION OF AN ANTIBIOTIC POLYPEPTIDE FROM LACTOFERRIN
    David Mann; Fiscal Year: 1999
    DESCRIPTION: Dr. Mann has identified a 6 kDa N-terminal domain of human lactoferrin (LF), derived from neutrophil lysosomes, that has both glycosaminoglycan (GAG)-binding and antibacterial activities...
  58. LACTOFERRIN AND DEVELOPMENT OF INFLAMMATION
    Marian Kruzel; Fiscal Year: 2000
    ..One of these mediators is lactoferrin, an iron binding protein found in high concentration in most exocrine secretions in humans...
  59. Innate Immunity and exacerbations of COPD
    Sanjay Sethi; Fiscal Year: 2009
    ..2 sputum and bronchoalveolar lavage concentrations of airway antimicrobial polypeptides, specifically lysozyme, lactoferrin, secretory leucocyte protease inhibitor (SLPI) and surfactant proteins A (SP-A) and D (SP-D) will be determined ..
  60. THERAPY FOR GASTROINTESTINAL DISORDERS
    Elizabeth Dial; Fiscal Year: 1999
    The main objective of this research proposal is to determine the efficacy of recombinant human lactoferrin (hLF) to treat gastrointestinal disorders induced by Helicobacter pylori infection or NSAID toxicity...
  61. Conference on Lactoferrin: Functions and Applications
    ORLA CONNEELY; Fiscal Year: 2001
    The 5th international conference on Lactoferrin will be held at the Banff Conference Center, Canada from May 4-9, 2001...
  62. 4-Hydroxyestradiol Receptor in Breast Cancer
    Jose Russo; Fiscal Year: 2005
    ..of 4-hydroxyestradiol include induction of blastocyst implantation in the uterus and upregulation of uterine lactoferrin gene expression 60 fold over vehicle controls compared to less than a doubling by E2...
  63. Bioactivity and Vitamins in Flash-heated Breastmilk
    Caroline Chantry; Fiscal Year: 2005
    ..1) vitamin content and protein digestibility; 2) key bioactive proteins (immunoglobulin A, lysozyme and lactoferrin); 3) antibacterial activity...
  64. Mammalian Lactoferrin Receptors: Structure and Function
    Bo Lonnerdal; Fiscal Year: 2007
    b>Lactoferrin (Lf), an 80 kD glycoprotein that can bind two atoms of Fe(lll), is a major protein in human milk, and also present in exocrine secretions, e.g. pancreatic fluid and bile, and in neutrophils...