lactoferrin

Summary

Gene Symbol: lactoferrin
Description: lactotransferrin
Alias: GIG12, HLF2, growth-inhibiting protein 12, neutrophil lactoferrin, talalactoferrin
Species: human

Top Publications

  1. ncbi Human delta-lactoferrin is a transcription factor that enhances Skp1 (S-phase kinase-associated protein) gene expression
    Christophe Mariller
    Unite de Glycobiologie Structurale et Fonctionnelle, Unité Mixte de Recherche 8576 CNRS Université des Sciences et Technologies de Lille1, Villeneuve d Ascq, France
    FEBS J 274:2038-53. 2007
  2. ncbi Efficacy of a lactoferrin-penicillin combination to treat {beta}-lactam-resistant Staphylococcus aureus mastitis
    D Petitclerc
    Crea Biopharma Inc, Sherbrooke, Quebec, Canada J1E 4K8
    J Dairy Sci 90:2778-87. 2007
  3. ncbi Serum lactoferrin and immunoglobulin G concentrations in healthy or ill neonatal foals and healthy adult horses
    Michelle Henry Barton
    Department of Large Animal Medicine, College of Veterinary Medicine, The University of Georgia, Athens, GA, USA
    J Vet Intern Med 20:1457-62. 2006
  4. ncbi Down regulation of 3p genes, LTF, SLC38A3 and DRR1, upon growth of human chromosome 3-mouse fibrosarcoma hybrids in severe combined immunodeficiency mice
    Irina D Kholodnyuk
    Microbiology and Tumour Biology Center, Karolinska Institute, Stockholm, Sweden
    Int J Cancer 119:99-107. 2006
  5. ncbi Genetic and epigenetic inactivation of LTF gene at 3p21.3 in lung cancers
    Hironobu Iijima
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Maebashi, Gunma 371 8511, Japan
    Int J Cancer 118:797-801. 2006
  6. pmc Human lactoferrin but not lysozyme neutralizes HSV-1 and inhibits HSV-1 replication and cell-to-cell spread
    Hannamari Valimaa
    Institute of Dentistry, University of Turku, Turku, Finland
    Virol J 6:53. 2009
  7. pmc Comparison of human immunodeficiency virus type 1-specific inhibitory activities in saliva and other human mucosal fluids
    Shamim H Kazmi
    Oral AIDS Research Unit, Department of Oral Medicine and Immunology, King s College London Dental Institute at Guy s, King s College, and St Thomas Hospitals, Floor 28, Guy s Tower, King s College London, London SE1 9RT, United Kingdom
    Clin Vaccine Immunol 13:1111-8. 2006
  8. doi Lactoferrin is a novel predictor of fatal ischemic heart disease in diabetes mellitus type 2: long-term follow-up of the HUNT 1 study
    Inga Thorsen Vengen
    Department of Laboratory Medicine, Children s and Women s Health, Norwegian University of Science and Technology, and Department of Cardiology, Trondheim University Hospital, Trondheim, Norway
    Atherosclerosis 212:614-20. 2010
  9. doi Human lactoferrin suppresses TNF-α-induced intercellular adhesion molecule-1 expression via competition with NF-κB in endothelial cells
    Chan Woo Kim
    College of Life Science and Graduate School of Biotechnology, Kyung Hee University, Yongin 446 701, Republic of Korea
    FEBS Lett 586:229-34. 2012
  10. ncbi Differential modulation of human lactoferrin activity against both R5 and X4-HIV-1 adsorption on epithelial cells and dendritic cells by natural antibodies
    Hela Saidi
    Universite Rene Descartes Paris V, Unité Institut National de la Recherche et de la Santé INSERM Internationale 743 d Immunologie Humaine, Centres de Recherches Biomédicales des Cordeliers, Paris, France
    J Immunol 177:5540-9. 2006

Detail Information

Publications217 found, 100 shown here

  1. ncbi Human delta-lactoferrin is a transcription factor that enhances Skp1 (S-phase kinase-associated protein) gene expression
    Christophe Mariller
    Unite de Glycobiologie Structurale et Fonctionnelle, Unité Mixte de Recherche 8576 CNRS Université des Sciences et Technologies de Lille1, Villeneuve d Ascq, France
    FEBS J 274:2038-53. 2007
    Delta-lactoferrin is a cytoplasmic lactoferrin isoform that can locate to the nucleus, provoking antiproliferative effects and cell cycle arrest in S phase...
  2. ncbi Efficacy of a lactoferrin-penicillin combination to treat {beta}-lactam-resistant Staphylococcus aureus mastitis
    D Petitclerc
    Crea Biopharma Inc, Sherbrooke, Quebec, Canada J1E 4K8
    J Dairy Sci 90:2778-87. 2007
    ..The efficacy of intramammary (IM) treatments containing penicillin G (PG) alone or a combination of PG and bovine lactoferrin (bLF) was evaluated using a model of experimentally induced chronic bovine mastitis caused by a clinical ..
  3. ncbi Serum lactoferrin and immunoglobulin G concentrations in healthy or ill neonatal foals and healthy adult horses
    Michelle Henry Barton
    Department of Large Animal Medicine, College of Veterinary Medicine, The University of Georgia, Athens, GA, USA
    J Vet Intern Med 20:1457-62. 2006
    b>Lactoferrin is a colostral glycoprotein with antimicrobial properties.
  4. ncbi Down regulation of 3p genes, LTF, SLC38A3 and DRR1, upon growth of human chromosome 3-mouse fibrosarcoma hybrids in severe combined immunodeficiency mice
    Irina D Kholodnyuk
    Microbiology and Tumour Biology Center, Karolinska Institute, Stockholm, Sweden
    Int J Cancer 119:99-107. 2006
    ..Our data indicate these genes as putative tumour suppressor genes...
  5. ncbi Genetic and epigenetic inactivation of LTF gene at 3p21.3 in lung cancers
    Hironobu Iijima
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Maebashi, Gunma 371 8511, Japan
    Int J Cancer 118:797-801. 2006
    ..The lactotransferrin gene (LTF, also referred to as the lactoferrin gene, LF) is located at 3p21...
  6. pmc Human lactoferrin but not lysozyme neutralizes HSV-1 and inhibits HSV-1 replication and cell-to-cell spread
    Hannamari Valimaa
    Institute of Dentistry, University of Turku, Turku, Finland
    Virol J 6:53. 2009
    ..In the current study, we investigated the anti-HSV-1 activity of human lactoferrin (hLf) and lysozyme (hLz), two highly cationic polypeptides of the mucosal innate defence system...
  7. pmc Comparison of human immunodeficiency virus type 1-specific inhibitory activities in saliva and other human mucosal fluids
    Shamim H Kazmi
    Oral AIDS Research Unit, Department of Oral Medicine and Immunology, King s College London Dental Institute at Guy s, King s College, and St Thomas Hospitals, Floor 28, Guy s Tower, King s College London, London SE1 9RT, United Kingdom
    Clin Vaccine Immunol 13:1111-8. 2006
    ..Incubation of unfractionated and fractionated whole saliva with antibodies raised against human lactoferrin (hLf), secretory leukocyte protease inhibitor (SLPI), and, to a lesser extent, MG2 (high-molecular-weight ..
  8. doi Lactoferrin is a novel predictor of fatal ischemic heart disease in diabetes mellitus type 2: long-term follow-up of the HUNT 1 study
    Inga Thorsen Vengen
    Department of Laboratory Medicine, Children s and Women s Health, Norwegian University of Science and Technology, and Department of Cardiology, Trondheim University Hospital, Trondheim, Norway
    Atherosclerosis 212:614-20. 2010
    ..aim of this study was to compare the predictive values of two neutrophil degranulation products, myeloperoxidase and lactoferrin, on long-term risk for fatal ischemic heart disease in persons with newly diagnosed diabetes and controls.
  9. doi Human lactoferrin suppresses TNF-α-induced intercellular adhesion molecule-1 expression via competition with NF-κB in endothelial cells
    Chan Woo Kim
    College of Life Science and Graduate School of Biotechnology, Kyung Hee University, Yongin 446 701, Republic of Korea
    FEBS Lett 586:229-34. 2012
    b>Lactoferrin (Lf) is known to have anti-inflammatory activity, but the mechanisms of action by Lf remain to be elucidated...
  10. ncbi Differential modulation of human lactoferrin activity against both R5 and X4-HIV-1 adsorption on epithelial cells and dendritic cells by natural antibodies
    Hela Saidi
    Universite Rene Descartes Paris V, Unité Institut National de la Recherche et de la Santé INSERM Internationale 743 d Immunologie Humaine, Centres de Recherches Biomédicales des Cordeliers, Paris, France
    J Immunol 177:5540-9. 2006
    Human lactoferrin (Lf) is an iron binding glycoprotein that is present in several mucosal secretions. Many biological functions have been ascribed to Lf...
  11. doi Endocytosis and trafficking of human lactoferrin in macrophage-like human THP-1 cells (1)
    Paula Florian
    Institute of Biochemistry of the Romanian Academy, Spl Independentei 296, Bucharest 17 060031, Romania
    Biochem Cell Biol 90:449-55. 2012
    Different cell types have been reported to internalize lactoferrin (Lf) by specific or nonspecific receptors. Our studies focused on the endocytic pathway of human Lf in macrophage-like THP-1 cells...
  12. ncbi The antiviral activity of the milk protein lactoferrin against the human immunodeficiency virus type 1
    Ben Berkhout
    Department of Human Retrovirology, Academic Medical Center, University of Amsterdam, Meibergdreef 15, 1105 AZ Amsterdam, The Netherlands
    Biometals 17:291-4. 2004
    ..In this manuscript, we review the antiviral properties of the milk protein lactoferrin (LF)...
  13. ncbi Antiviral activities of lactoferrin
    B W van der Strate
    Department of Pharmacokinetics and Drug Delivery, Groningen University Institute for Drug Exploration GUIDE, A Deusinglaan 1, 9713 AV Groningen, The Netherlands
    Antiviral Res 52:225-39. 2001
    b>Lactoferrin (LF) is an iron binding glycoprotein that is present in several mucosal secretions. Many biological functions have been ascribed to LF...
  14. ncbi High prevalence of autoantibodies against carbonic anhydrase II and lactoferrin in type 1 diabetes: concept of autoimmune exocrinopathy and endocrinopathy of the pancreas
    Takao Taniguchi
    Department of Internal Medicine, Ohtsu Red Cross Hospital, Shiga, Japan
    Pancreas 27:26-30. 2003
    ..Dysfunction of the exocrine as well as the endocrine pancreas has been reported in type 1 diabetes. Lymphocytic infiltration of the exocrine pancreas is observed in approximately half of Japanese type 1 diabetic patients...
  15. ncbi Lactoferrin down-modulates the activity of the granulocyte macrophage colony-stimulating factor promoter in interleukin-1 beta-stimulated cells
    S Penco
    Institute of Biology and Genetics, University of Genova, Italy
    J Biol Chem 270:12263-8. 1995
    The human neutrophil lactoferrin (Lf), a cationic iron-binding glycoprotein, has an inhibitor role on granulocyte macrophage colony-stimulating factor (GM-CSF) production via interleukin-1 (IL-1)...
  16. pmc Human lactoferrin interacts with soluble CD14 and inhibits expression of endothelial adhesion molecules, E-selectin and ICAM-1, induced by the CD14-lipopolysaccharide complex
    S Baveye
    Laboratoire de Chimie Biologique et Unité Mixte de Recherche no 8576 du Centre National de la Recherche Scientifique, Universite des Sciences et Technologies de Lille, 59655 Villeneuve d Ascq cedex, France
    Infect Immun 68:6519-25. 2000
    ..b>Lactoferrin (Lf), a LPS-chelating glycoprotein, protects animals against septic shock...
  17. ncbi Multifunctional roles of lactoferrin: a critical overview
    P P Ward
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Cell Mol Life Sci 62:2540-8. 2005
    b>Lactoferrin (LF) is a member of the transferrin family that is expressed and secreted by glandular epithelial cells and is found in the secondary granules of neutrophils...
  18. pmc Lactoferrin prevents dendritic cell-mediated human immunodeficiency virus type 1 transmission by blocking the DC-SIGN--gp120 interaction
    Fedde Groot
    Department of Human Retrovirology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Virol 79:3009-15. 2005
    ..tested proteins from milk and serum for their ability to block DC-mediated HIV-1 transmission, of which bovine lactoferrin (bLF) is the most potent inhibitor...
  19. ncbi Identification of an import signal for, and the nuclear localization of, human lactoferrin
    S Penco
    Department of Oncology, Biology and Genetics, University of Genoa, Viale Benedetto XV, 6 Genoa, Italy
    Biotechnol Appl Biochem 34:151-9. 2001
    Many different unique functions have been attributed to lactoferrin (Lf), including DNA and RNA binding, and transport into the nucleus, where Lf binds to specific sequences and activates transcription...
  20. ncbi Surface nucleolin participates in both the binding and endocytosis of lactoferrin in target cells
    Dominique Legrand
    Institut Fédératif de Recherche n degrees 118, Universite des Sciences et Technologies de Lille, Villeneuve d Ascq, France
    Eur J Biochem 271:303-17. 2004
    b>Lactoferrin (Lf), a multifunctional molecule present in mammalian secretions and blood, plays important roles in host defense and cancer...
  21. ncbi Genetic and epigenetic alterations of LTF at 3p21.3 in nasopharyngeal carcinoma
    Hong Mei Yi
    Cancer Research Institute, Xiang Ya School of Medicine, Central South University, Changsha, Hunan, P R China
    Oncol Res 16:261-72. 2006
    To investigate the roles of lactotransferrin gene (LTF, also referred to as the lactoferrin gene, LF), located at 3p21...
  22. ncbi Bovine whey fractionation based on cation-exchange chromatography
    R Hahn
    Institute of Applied Microbiology, University of Agriculture, Forestry and Biotechnology, Vienna, Austria
    J Chromatogr A 795:277-87. 1998
    ..A fractionation scheme for the economically interesting proteins, such as IgG, lactoferrin and lactoperoxidase, based on cation exchangers was the goal of our investigations...
  23. ncbi Metal storage and transport proteins increase after exposure of the rat lung to an air pollution particle
    A J Ghio
    National Health and Environmental Effects Research Laboratory, Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Toxicol Pathol 26:388-94. 1998
    ..We tested the hypothesis that the concentrations of both lactoferrin and ferritin in the rat lung increase after exposure to a metal-rich emission source air pollution particle...
  24. ncbi [Disturbed neutrophil activation in pneumonia during medicinal immunosuppression]
    J Braun
    Medizinische Klinik II,
    Pneumologie 51:1037-42. 1997
    ..cell differential the BALF concentrations of the neutrophil degranulation products myeloperoxidase (MPO) and lactoferrin were determined using immunoluminometric assays...
  25. ncbi Subcellular distribution of urokinase and urokinase receptor in human neutrophils determined by immunoelectron microscopy
    T L Pedersen
    Department of Pathology, Herlev Hospital, University of Copenhagen, Denmark
    Ultrastruct Pathol 24:175-82. 2000
    ..markers for well-defined subtypes of granules: matrix metalloproteinase type-9 (MMP-9) for gelatinase granules, lactoferrin (LF) for specific granules, and myeloperoxidase (MPO) and neutrophil elastase (NE) for primary granules...
  26. ncbi Abnormal cell differentiation and p21 expression of endometrial epithelial cells following developmental exposure to diethylstilbestrol (DES)
    A Yoshida
    Laboratory of Experimental Pathology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Toxicol Pathol 28:237-45. 2000
    ..These cells also showed increased expression of lactoferrin, a sensitive protein marker of estrogen exposure, although the staining intensity decreased after exposure ..
  27. ncbi Immunohistochemical study of ceruloplasmin, lactoferrin and secretory component expression in neoplastic and non-neoplastic thyroid gland diseases
    A Kondi-Pafiti
    Department of Pathology, Athens University, School of Medicine, Areteion Hospital, Greece
    Acta Oncol 39:753-6. 2000
    The expression of lactoferrin (LF), ceruloplasmin (CP) and secretory component (SC) in various thyroid diseases was investigated using an immunohistochemical method...
  28. ncbi Towards a closed eye model of the pre-ocular tear layer
    R A Sack
    SUNY, College of Optometry, 100 East 20 Street, Manhattan, NY 10010, USA
    Prog Retin Eye Res 19:649-68. 2000
    ..an inducible, neurologically controlled, lacrimal secretion containing among other proteins primarily lysozyme, lactoferrin and tear specific lipocalin, to a much slower, constitutive-type of secretion, composed almost exclusively of ..
  29. ncbi [Reverting effect of cysteine on the suppression by glucose or dexamethasone of anti-Candida activity of human neutrophils]
    T Tansho
    Department of Surgery II, Teikyo University School of Medicine
    Kansenshogaku Zasshi 72:727-37. 1998
    ..Correspondingly, cysteine augmented production of lactoferrin by stimulated neutrophils; which functions as a major effector molecule in growth inhibition of Candida by ..
  30. ncbi [Myeloperoxidase, lactoferrin and elastase in bronchoalveolar lavage and plasma in pneumonia]
    J Braun
    ,
    Pneumologie 46:141-7. 1992
    ..BALF) and in plasma, the concentration of the locally produced granulocyte products myeloperoxidase (MPO), lactoferrin (LF) and elastase-alpha 1 proteinase complex (ELA) as well as of the alpha 1 proteinase inhibitor (alpha 1 Pi) ..
  31. ncbi Thin-layer ion-exchange chromatography of proteins
    Q Luo
    Department of Materials Science and Engineering, University of Utah, Salt Lake City 84112-0560, USA
    J Chromatogr A 816:97-105. 1998
    ..The net charges were calculated for four model proteins, albumin, transferrin, lactoferrin and lysozyme, under different pH values...
  32. ncbi Two ion-exchange chromatographic methods for the isolation of antibacterial peptides from lactoferrin. In situ enzymatic hydrolysis on an ion-exchange membrane
    I Recio
    Department of Product Technology, NIZO Food Research, Ede, The Netherlands
    J Chromatogr A 831:191-201. 1999
    Two ion-exchange chromatographic methods are reported for the rapid isolation of antibacterial peptides from lactoferrin (LF)...
  33. ncbi A rapid and efficient physiologic chemical method of labeling plasma proteins with indium-111
    D W Wong
    Department of Radiology, King Drew Medical Center U C L A 90059
    Int J Rad Appl Instrum A 38:1067-72. 1987
    ..Human serum albumin, IgG, fibrinogen, transferrin, lactoferrin and the enzyme bovine thrombin had been successfully labeled with exceptionally high labeling yields of greater ..
  34. ncbi Determination of the minor whey protein bovine lactoferrin in cheese whey concentrates with capillary electrophoresis
    P Riechel
    , , Germany
    J Chromatogr A 817:187-93. 1998
    In our present work we present the determination of bovine lactoferrin in whey concentrates as they are typically produced by milk and cheese industry after production of cheese...
  35. ncbi [Bacteriostatic activity of bovine colostrum]
    H Ushijima
    Department of Enteroviruses, National Institute of Health
    Kansenshogaku Zasshi 65:54-60. 1991
    ..of non immunized bovine colostrum immunoglobulin, we studied the bacteriostatic activity of the immunoglobulin, lactoferrin and lactoferrin Fe by using the automated antimicrobial susceptibility testing system...
  36. ncbi Differential spatiotemporal regulation of lactoferrin and progesterone receptor genes in the mouse uterus by primary estrogen, catechol estrogen, and xenoestrogen
    S K Das
    Department of Molecular and Integrative Physiology, University of Kansas Medical Center, Ralph L Smith Research Center, Kansas City 66160 7338, USA
    Endocrinology 139:2905-15. 1998
    ..E2) and 4-hydroxyestradiol-17beta (4-OH-E2), a catechol metabolite of E2, on uterine expression of lactoferrin (LF) and progesterone receptor (PR). These genes are estrogen responsive in the mouse uterus...
  37. ncbi Oral lactoferrin for the prevention of sepsis and necrotizing enterocolitis in preterm infants
    Mohan P Venkatesh
    Pediatrics, Section of Neonatology, Baylor College of Medicine, 6621, Fannin, MC WT 6 104, Houston, Texas, USA, 77030
    Cochrane Database Syst Rev 5:CD007137. 2010
    BACKGROUND: Lactoferrin, a normal component of human colostrum, milk, tears and saliva can enhance host defence and may be effective in the prevention of sepsis and necrotizing enterocolitis (NEC) in preterm neonates...
  38. pmc Host iron binding proteins acting as niche indicators for Neisseria meningitidis
    Philip W Jordan
    The Bacterial Pathogenesis and Functional Genomics Group, The Sir William Dunn School of Pathology, University of Oxford, Oxford, United Kingdom
    PLoS ONE 4:e5198. 2009
    ..available iron sources differ, particularly the host iron-binding proteins haemoglobin, transferrin, and lactoferrin. This study compared the transcriptional responses of N...
  39. doi Effects of colostrum replacer supplemented with lactoferrin on the blood plasma immunoglobulin G concentration and intestinal absorption of xylose in the neonatal calf
    E C Shea
    Department of Animal and Nutritional Sciences, University of New Hampshire, Durham 03824, USA
    J Anim Sci 87:2047-54. 2009
    The objective of this experiment was to determine the effect of lactoferrin (Lf) supplementation of colostrum replacer (CR) fed as 1 or 2 doses on apparent efficiency of IgG absorption, serum IgG concentrations, and xylose absorption/..
  40. ncbi Binding of extracellular matrix proteins by animal strains of staphylococcal species
    I Styriak
    Department of Microbiology, Institute of Animal Physiology, Slovak Academy of Sciences, Kosice, Slovakia
    Vet Microbiol 67:99-112. 1999
    ..Bovine lactoferrin, human vitronectin, human fibronectin, heparin, human and bovine serum albumin were immobilized on latex beads ..
  41. ncbi Lactoferrin expression in the canine uterus during the estrous cycle and with pyometra
    K Kida
    Department of Advanced Pathobiology, Graduate School of Life and Environmental Sciences, Osaka Prefecture University, Osaka 599 8531, Japan
    Theriogenology 66:1325-33. 2006
    The expression of lactoferrin, a non-specific antimicrobial defence, in the canine uterus during the normal estrous cycle and in bitches with pyometra was examined...
  42. doi A new chance of preventing winter diseases by the administration of synbiotic formulations
    Fabrizio Pregliasco
    Department of Public Health Microbiology Virology, Universita degli Studi di Milano, Milan, Italy Fabrizio
    J Clin Gastroenterol 42:S224-33. 2008
    ..containing 3 to 5 strains of Lactobacillus plantarum, Lactobacillus rhamnosus, and Bifidobacterium lactis, lactoferrin and prebiotics such as either FOS (short-chain fructooligosaccharides) or GOS (galactooligosaccharides)...
  43. ncbi Lactoferrin-enhanced anoikis: a defense against neonatal necrotizing enterocolitis
    Michael P Sherman
    Division of Neonatology, School of Medicine, University of California, Surge I, Suite 1121, Davis, CA 95616, USA
    Med Hypotheses 65:478-82. 2005
    Enteral nutrition with human milk lowers the incidence of necrotizing enterocolitis in preterm human infants. Lactoferrin, the major whey protein in human milk, has many functions related to host defense against bacterial infection...
  44. doi Use and endocytosis of iron-containing proteins by Entamoeba histolytica trophozoites
    Fernando López-Soto
    Departamento de Biologia Celular, Centro de Investigacion y de Estudios Avanzados del IPN, Mexico, DF 07000, Mexico
    Infect Genet Evol 9:1038-50. 2009
    ..all organisms; in mammals, it is part of proteins such as haemoglobin, and it is captured by transferrin and lactoferrin. Transferrin is present in serum, and lactoferrin is secreted by the mucosa and by neutrophils at infection ..
  45. pmc Diarrhea, clostridium difficile, and intestinal inflammation in residents of a long-term care facility
    Laurie Archbald-Pannone
    University of Virginia, Department of Internal Medicine, Division of General Medicine, Section of Geriatrics, Charlottesville, VA 22908, USA
    J Am Med Dir Assoc 11:263-7. 2010
    ....
  46. ncbi Utilization of lactoferrin to fight antibiotic-resistant mammary gland pathogens
    P Lacasse
    Agriculture and Agri Food Canada, Dairy and Swine Research and Development Centre, PO Box 90 STN Lennoxville, Sherbrooke, Quebec, Canada J1M 1Z3
    J Anim Sci 86:66-71. 2008
    ..b>Lactoferrin (Lf) is naturally produced by the mammary gland...
  47. doi Characterization of lactoferrin receptor on human spermatozoa
    Peng Wang
    Laboratory of Reproductive Medicine, Department of Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China
    Reprod Biomed Online 22:155-61. 2011
    b>Lactoferrin (LF) is abundant in human seminal plasma and on sperm surfaces. However, lactoferrin receptor (LFR) on human spermatozoa has not yet been reported...
  48. ncbi Characterization of the infection-responsive bovine lactoferrin promoter
    Jiamao Zheng
    Lactation and Mammary Gland Biology Group, Department of Animal Science, 213 Terrill Hall, University of Vermont, Burlington, VT 05405, USA
    Gene 353:107-17. 2005
    The concentration of lactoferrin in bovine milk is dramatically increased in response to infection. The high levels of lactoferrin may have a role in the prevention of microbial infection of the mammary gland...
  49. ncbi [The role of lactoferrin in the iron metabolism. Part II. Antimicrobial and antiinflammatory effect of lactoferrin by chelation of iron]
    Jolanta Artym
    Zakład Terapii Doświadczalnej Instytutu Immunologii i Terapii Doświadczalnej PAN im L Hirszfelda we Wrocławiu, 53 114 Wrocław
    Postepy Hig Med Dosw (Online) 64:604-16. 2010
    b>Lactoferrin (LF) is a glycoprotein widely distributed in mammalian organisms. It is synthesized by epithelial cells; hence it is present in secretions of mucous membranes...
  50. pmc Coadsorption of human milk lactoferrin into the dipalmitoylglycerolphosphatidylcholine phospholipid monolayer spread at the air/water interface
    Fausto Miano
    Società Industria Farmaceutica Italiana SpA, Lavinaio Catania, Italy
    Biophys J 92:1254-62. 2007
    The coadsorption of human milk lactoferrin into a spread monolayer of dipalmitoylglycerol phosphatidylcholine (DPPC) at the air/water interface has been studied by neutron reflection...
  51. doi Bovine lactoferrin inhibits Japanese encephalitis virus by binding to heparan sulfate and receptor for low density lipoprotein
    Yu Jung Chien
    Graduate Institute of Veterinary Public Health, College of Veterinary Medicine, National Chung Hsing University, Taichung, Taiwan
    Virology 379:143-51. 2008
    b>Lactoferrin is a natural anti-microbial protein which affects Japanese encephalitis virus (JEV) activity...
  52. ncbi Elevated free tear lactoferrin levels in leprosy are associated with Type 2 reactions
    Ebenezer Daniel
    Department of Ophthalmology, Schieffelin Leprosy Research and Training Center, Tamil Nadu, India
    Indian J Ophthalmol 52:51-6. 2004
    To determine the association of demographics, leprosy and ocular characteristics with altered levels of lactoferrin in the tears of normal subjects and leprosy patients, and to detect the presence of antibodies to lactoferrin in these ..
  53. doi Bovine lactoferrin supplementation for prevention of late-onset sepsis in very low-birth-weight neonates: a randomized trial
    Paolo Manzoni
    Neonatology and Neonatal Intensive Care Unit, S Anna Hospital, Azienda Ospedaliera Regina Margherita S Anna, C Spezia 60, 10126 Torino, Italy
    JAMA 302:1421-8. 2009
    ..Whether lactoferrin, a mammalian milk glycoprotein involved in innate immune host defenses, can reduce the incidence of sepsis is ..
  54. ncbi Rapid purification of porcine colostral whey lactoferrin by affinity chromatography on single-stranded DNA-agarose. Characterization, amino acid composition and N-terminal amino acid sequence
    T W Hutchens
    USDA ARS Children s Nutrition Research Center, Department of Pediatries, Baylor College of Medicine, Houston 77030
    Biochim Biophys Acta 999:323-9. 1989
    We have determined that the major iron-binding and DNA-binding protein in porcine colostral whey is lactoferrin. This lactoferrin was purified to homogeneity in one chromatographic step using immobilized single-stranded DNA-agarose...
  55. ncbi The low-density lipoprotein receptor-related protein 1 is a mitogenic receptor for lactoferrin in osteoblastic cells
    Andrew Grey
    Department of Medicine, University of Auckland, Private Bag 92019, Auckland, New Zealand
    Mol Endocrinol 18:2268-78. 2004
    b>Lactoferrin induces osteoblast proliferation and survival in vitro and is anabolic to bone in vivo...
  56. ncbi A curcumin-based 1-week triple therapy for eradication of Helicobacter pylori infection: something to learn from failure?
    Francesco Di Mario
    Section of Gastroenterology, Department of Clinical Sciences, University of Parma, Italy
    Helicobacter 12:238-43. 2007
    ..N-acetylcysteine and lactoferrin with their respective mucolytic and antibacterial activities might also be effective in H...
  57. ncbi Noninvasive markers in the assessment of intestinal inflammation in inflammatory bowel diseases: performance of fecal lactoferrin, calprotectin, and PMN-elastase, CRP, and clinical indices
    Jost Langhorst
    Department of Internal and Integrative Medicine, Kliniken Essen Mitte, University of Duisburg Essen, Germany
    Am J Gastroenterol 103:162-9. 2008
    The aim of this study was to compare the performance of fecal lactoferrin (Lf), calprotectin (Cal), polymorphonuclear neutrophil elastase (PMN-e), as well as serum C-reactive protein (CRP) in patients with inflammatory bowel diseases (..
  58. ncbi Anti-neutrophil cytoplasmic antibodies in patients with chronic liver diseases: prevalence, antigen specificity and predictive value for diagnosis of autoimmune liver disease. Swedish Internal Medicine Liver Club (SILK)
    S Lindgren
    Department of Medicine, University Hospital, Malmo, Sweden
    J Gastroenterol Hepatol 15:437-42. 2000
    ..As their predictive value for autoimmune liver disease remains unknown, we analysed the prevalence and antigen specificity of ANCA in patients with various chronic liver diseases (CLD)...
  59. doi Short communication: Antimicrobial effect of lactoferrin and its amidated and pepsin-digested derivatives against Salmonella Enteritidis and Pseudomonas fluorescens
    A del Olmo
    Departamento de Tecnologia de Alimentos, INIA, Carretera de la Coruña Km 7, Madrid, 28040 Spain
    J Dairy Sci 93:3965-9. 2010
    The antimicrobial effect of bovine lactoferrin (LF) and its amidated and pepsin-digested derivatives, at concentrations varying from 0...
  60. doi Glycosaminoglycans are not indispensable for the anti-herpes simplex virus type 2 activity of lactoferrin
    M Marchetti
    Department of Technology and Health, Istituto Superiore di Sanita, Viale Regina Elena 299, 00161 Rome, Italy
    Biochimie 91:155-9. 2009
    b>Lactoferrin has been recognized as a potent inhibitor of human herpetic viruses, such as herpes simplex type 1 (HSV-1) and 2 (HSV-2)...
  61. ncbi Variation in antimicrobial activity of lactoferricin-derived peptides explained by structure modelling
    Sebastien Farnaud
    Randall Division of Cell and Molecular Biophysics, King s College London, New Hunt s House, Guy s Campus, St Thomas Street, London SE1 1UL, UK
    FEMS Microbiol Lett 238:221-6. 2004
    ..peptides bovine lactoferricin (LfcinB) and human lactoferricin (LfcinH) are produced from the respective lactoferrin, but are more active than their precursors...
  62. ncbi Activated lactoferrin and fluconazole synergism against Candida albicans and Candida glabrata vaginal isolates
    A Satyanarayan Naidu
    N terminus Research Laboratory, Pomona, CA 91768, USA
    J Reprod Med 49:800-7. 2004
    To evaluate the fungistatic activity of activated lactoferrin (ALF), fluconazole (FCN) individually and in combination against Candida vaginal isolates as well as to measure the time to recovery from the fungistatic effects after ..
  63. ncbi Biochemical analysis of lactoferrin receptors in the Neisseriaceae: identification of a second bacterial lactoferrin receptor protein
    R A Bonnah
    Department of Microbiology and Infectious Diseases, University of Calgary, Alberta, Canada
    Microb Pathog 19:285-97. 1995
    ..In contrast, bacterial lactoferrin receptors have only been described for human pathogens in the family Neisseriaceae, and were believed to ..
  64. pmc Recognition of lactoferrin and aminopeptidase M-modified lactoferrin by the liver: involvement of proteoglycans and the remnant receptor
    G J Ziere
    Division of Biopharmaceutics, Leiden Amsterdam Center for Drug Research, University of Leiden, Sylvius Laboratory, The Netherlands
    Biochem J 313:289-95. 1996
    1. Lactoferrin and aminopeptidase M-modified lactoferrin (APM-lactoferrin; which lacks its 14 N-terminal amino acids) inhibit the liver uptake of lipoprotein remnant...
  65. ncbi Effect of dietary lactoferrin on the immune functions and serum iron level of weanling piglets
    T Shan
    Institute of Feed Science, Zhejiang University, The Key Laboratory of Molecular Animal Nutrition, Ministry of Education, No 164 Qiutao North Road, Hangzhou 310029, PR China
    J Anim Sci 85:2140-6. 2007
    ..female pigs (Duroc x Landrace x Yorkshire) were used in a 30-d growth experiment to investigate the effect of lactoferrin (LF) on growth performance, immune function, and serum iron concentrations...
  66. ncbi [Muramidase and lactoferrin in adenoidal hypertrophies, hypertrophic and chronic infected tonsil tissue--a quantitative analysis]
    M Schwaab
    Universitätsklinik für Hals Nasen Ohrenheilkunde und Kopf und Halschirurgie, Ruhr Universitat Bochum
    Laryngorhinootologie 84:660-4. 2005
    Muramidase and lactoferrin are important components of the antimicrobial defense system. Muramidase has the ability of opsonization and immunopotentiation and therefore a close relation to the lymphatic tissue...
  67. ncbi Lactoferrin given in food facilitates dermatophytosis cure in guinea pig models
    H Wakabayashi
    Nutritional Science Laboratory, Morinaga Milk Industry Co Ltd, Zama, Kanagawa 228 8583, Japan
    J Antimicrob Chemother 46:595-602. 2000
    ..We studied the in vitro and in vivo antifungal effects of lactoferrin against Trichophyton...
  68. ncbi Effect of lactoferrin on Helicobacter felis induced gastritis
    Elizabeth J Dial
    Department of Integrative Biology and Pharmacology, University of Texas Health Science Center, Houston Medical School, 77225, USA
    Biochem Cell Biol 80:113-7. 2002
    b>Lactoferrin possesses antibiotic, antiinflammatory, and immune-modulating properties that may be active against the gastritis-, ulcer- and cancer-inducing bacterium Helicobacter pylori...
  69. doi The lactoferrin receptor complex in Gram negative bacteria
    Amanda J Beddek
    Department of Microbiology and Infectious Diseases, University of Calgary, Rm G503A Health Sciences Center, 3330 Hospital Drive N W, Calgary, AB, Canada T2N 4N1
    Biometals 23:377-86. 2010
    ..environment on the mucosal surface where iron is complexed by the host iron-binding proteins transferrin and lactoferrin. Lactoferrin is also present in high concentrations at sites of inflammation where the cationic anti-microbial ..
  70. ncbi Lactoferrin sequestration and its contribution to iron-deficiency anemia in Helicobacter pylori-infected gastric mucosa
    Yon Ho Choe
    Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
    J Gastroenterol Hepatol 18:980-5. 2003
    It is known that lactoferrin serves as a source of iron for Helicobacter pylori in gastric mucosa. The present study was undertaken to investigate the relationship between lactoferrin and H...
  71. ncbi Salivary lactoferrin and low-Mr mucin MG2 in Actinobacillus actinomycetemcomitans-associated periodontitis
    J Groenink
    Department of Oral Biochemistry, Academic Centre for Dentistry Amsterdam ACTA, The Netherlands
    J Clin Periodontol 26:269-75. 1999
    Concentrations and output of lactoferrin and of low-Mr mucin MG2 were determined in saliva of subjects suffering from Actinobacillus actinomycetemcomitans-associated periodontal disease and healthy subjects...
  72. ncbi Comparative analysis of the transferrin and lactoferrin binding proteins in the family Neisseriaceae
    A B Schryvers
    Department of Microbiology and Infectious Diseases, University of Calgary, Alta, Canada
    Can J Microbiol 35:409-15. 1989
    Intact cells of several bacterial species were tested for their ability to bind human transferrin and lactoferrin by a solid-phase binding assay using horseradish peroxidase conjugated transferrin and lactoferrin...
  73. ncbi The synergistic effect of nisin and lactoferrin on the inhibition of Listeria monocytogenes and Escherichia coli O157:H7
    C A Murdock
    Rutgers, The State University of New Jersey, New Brunswick, New Jersey 08901 8520, USA
    Lett Appl Microbiol 44:255-61. 2007
    The goal of this study was to determine whether nisin and lactoferrin would act synergistically to inhibit the growth of Listeria monocytogenes and Escherichia coli O157:H7.
  74. ncbi Characterization of estrogen-responsive mouse lactoferrin promoter
    Y H Liu
    Developmental Endocrinology and Pharmacology Section, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709
    J Biol Chem 266:21880-5. 1991
    Mouse lactoferrin is expressed in a variety of tissues under different types of control...
  75. pmc Lactoferrin protects against development of hepatitis caused by sensitization of Kupffer cells by lipopolysaccharide
    M Yamaguchi
    Department of Nutritional Research, Nutrition Science Institute, Meiji Dairies Corporation, Odawara, Kanagawa, 250 0862 Japan
    Clin Diagn Lab Immunol 8:1234-9. 2001
    ..05 microg/g of body weight) 7 days after being primed with zymosan. Recombinant human lactoferrin (250 microg/g of body weight), intravenously administered 1 day before the injection of LPS, significantly ..
  76. pmc Lactoferrin binding to the rat asialoglycoprotein receptor requires the receptor's lectin properties
    D D McAbee
    Department of Chemistry and Biochemistry, California State University, Long Beach 90840 3903, USA
    Biochem J 348:113-7. 2000
    b>Lactoferrin binds to rat hepatic lectin 1 (RHL1), the major subunit of the asialoglycoprotein (ASGP) receptor, with high affinity, by a galactose-independent mechanism...
  77. doi Efficacy and tolerability of oral bovine lactoferrin compared to ferrous sulfate in pregnant women with iron deficiency anemia: a prospective controlled randomized study
    Carmine Nappi
    Department of Gynecology and Obstetrics, University of Naples Federico II, Via S Pansini 5, Naples, Italy
    Acta Obstet Gynecol Scand 88:1031-5. 2009
    To compare the effects of bovine lactoferrin with ferrous sulfate on iron nutritional status and to evaluate their tolerability in 100 pregnant women with iron deficiency anemia.
  78. ncbi Methoxychlor stimulates the mouse lactoferrin gene promoter through a GC-rich element
    Zhiping Zhang
    Gene Regulation Section, Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Biochem Cell Biol 80:23-6. 2002
    The lactoferrin gene in the mouse uterus is a target gene for natural estrogens and xenoestrogens. One of the xenoestrogens is methyoxychlor, an insecticide that displays both estrogenic and antiandrogenic activities...
  79. doi Bactericidal effect of lactoferrin and lactoferrin chimera against halophilic Vibrio parahaemolyticus
    Nidia León-Sicairos
    Departamento de Investigacion, Hospital Pediátrico de Sinaloa, Blvd Constitución S N, Culiacan, Sin 80200, Mexico
    Biochimie 91:133-40. 2009
    ..The aim of this work was to investigate whether lactoferrin and some lactoferrin-peptides have bactericidal activity against Vibrio parahaemolyticus ATCC 17802, the ..
  80. ncbi A prospective study of faecal calprotectin and lactoferrin in the monitoring of acute radiation proctitis in prostate cancer treatment
    Andrea Hille
    Department of Radiotherapy and Radio Oncology, University of Gottingen, Gottingen, Germany
    Scand J Gastroenterol 43:52-8. 2008
    ..Acute radiation proctitis is a relevant complication of pelvic radiation. The purpose of this study was to investigate two markers of gut inflammation as non-invasive diagnostic tools to evaluate acute radiation proctitis...
  81. ncbi Activated lactoferrin's ability to inhibit Candida growth and block yeast adhesion to the vaginal epithelial monolayer
    A Satyanarayan Naidu
    N terminus Research Laboratory, USA
    J Reprod Med 49:859-66. 2004
    To study in vitro growth-inhibitory effects of activated lactoferrin (ALF) against vaginal isolates of Candida species and to measure the ability of ALF to block interactions of Candida albicans and Candida glabrata to the vaginal ..
  82. ncbi Recombinant human lactoferrin treatment for global health issues: iron deficiency and acute diarrhea
    Delia R Bethell
    Ventria Bioscience, 4110 N Freeway Boulevard, Sacramento, California 95834, USA
    Biometals 17:337-42. 2004
    ..Recombinant human lactoferrin (rhLF), expressed and extracted from rice seed, is being evaluated by Ventria Bioscience for use as a dietary ..
  83. ncbi Recombinant human lactoferrin has a potential to suppresses uterine cervical ripening in preterm delivery in animal model
    K Yakuwa
    Department of Obstetrics and Gynecology, Showa University School of Medicine, 1 5 8 Hatanodai, Shinagawa ku, Tokyo 142 8666, Japan
    Arch Gynecol Obstet 275:331-4. 2007
    To investigate the effect of recombinant human lactoferrin (rhLF) on cervical ripening using a rabbit model in which preterm labor was induced by bacterial endotoxin lipopolysaccharide (LPS).
  84. ncbi Expression of bovine lactoferrin and lactoferrin N-lobe by recombinant baculovirus and its antimicrobial activity against Prototheca zopfii
    Tetsuya Tanaka
    Graduate School of Agriculture, Hokkaido University, Sapporo, Japan
    Biochem Cell Biol 81:349-54. 2003
    b>Lactoferrin (LF) is a multifunctional, iron-binding glycoprotein found in secretory fluids of mammals...
  85. ncbi Quadruple therapy with lactoferrin for Helicobacter pylori eradication: a randomised, multicentre study
    A Zullo
    Gastroenterology and Digestive Endoscopy, Nuovo Regina Margherita Hospital, Rome, Italy
    Dig Liver Dis 37:496-500. 2005
    Helicobacter pylori eradication rate with standard triple therapies is decreasing. Recently, lactoferrin administration has been shown to significantly increase the cure rate of 7-day rabeprazole, clarithromycin and tinidazole triple ..
  86. doi Microbicidal effect of the lactoferrin peptides lactoferricin17-30, lactoferrampin265-284, and lactoferrin chimera on the parasite Entamoeba histolytica
    Fernando López-Soto
    Laboratorio de Bioquímica de Proteínas, Departamento de Medicina y Ciencias de la Salud, Universidad de Sonora, Blvd Luis Encinas y Rosales, Col Centro, 83000 Hermosillo, Sonora, Mexico
    Biometals 23:563-8. 2010
    ..In some cases, trophozoites can travel to the liver leading to hepatic abscesses and death. Recently, lactoferrin and lactoferricin B have been shown to be amoebicidal in axenic cultures...
  87. doi Human recombinant lactoferrin acts synergistically with antimicrobials commonly used in neonatal practice against coagulase-negative staphylococci and Candida albicans causing neonatal sepsis
    Mohan Pammi Venkatesh
    Baylor College of Medicine and Texas Children s Hospital, 6621 Fannin, MC WT 6 104, Houston, TX 77030, USA
    J Med Microbiol 57:1113-21. 2008
    ..Coagulase-negative staphylococci (CoNS) and Candida frequently cause neonatal sepsis at >72 h of age. Lactoferrin, which is present in human milk, is a component of innate immunity and has broad-spectrum antimicrobial ..
  88. ncbi Effect of lactoferrin on the growth performance, intestinal morphology, and expression of PR-39 and protegrin-1 genes in weaned piglets
    Y Wang
    Institute of Feed Science, Zhejiang University, The Key Laboratory of Molecular Animal Nutrition, Ministry of Education, No 164 Qiutao North Road, Hangzhou 310029, P R China
    J Anim Sci 84:2636-41. 2006
    ..female pigs (Duroc x Landrace x Yorkshire) were used in a 15-d growth experiment to investigate the effect of lactoferrin on growth performance, intestinal morphology, and expression of PR-39 and protegrin-1 genes...
  89. doi Study of lactoferrin gene expression in human and mouse adipose tissue, human preadipocytes and mouse 3T3-L1 fibroblasts. Association with adipogenic and inflammatory markers
    José María Moreno-Navarrete
    Service of Diabetes, Endocrinology and Nutrition, Institut d Investigació Biomédica de Girona, CIBEROBN, CB06 03 010 and Instituto de Salud Carlos III, 17007 Girona, Spain
    J Nutr Biochem 24:1266-75. 2013
    b>Lactoferrin is considered an epithelial protein present in different gland secretions. Administration of exogenous lactoferrin is also known to modulate adipogenesis and insulin action in human adipocytes...
  90. ncbi Experimental immune-mediated pancreatitis in neonatally thymectomized mice immunized with carbonic anhydrase II and lactoferrin
    Kazushige Uchida
    Department of Gastroenterology and Endoscopic Medicine, Kyoto University Hospital, Kyoto, Japan
    Lab Invest 82:411-24. 2002
    We previously reported that autoantibodies against carbonic anhydrase II and lactoferrin are frequently identified in patients with autoimmune-related pancreatitis...
  91. doi The protective effects of lactoferrin against murine norovirus infection through inhibition of both viral attachment and replication
    Hiroki Ishikawa
    Department of Microbiology, Tokyo Medical University, Tokyo 160 8402, Japan
    Biochem Biophys Res Commun 434:791-6. 2013
    The purpose of this study was to evaluate the effects of bovine lactoferrin against norovirus infection using mouse norovirus (MNV) and Raw264.7 cell in vitro. When Raw264...
  92. ncbi Adsorption behaviour of lactoferrin in oil-in-water emulsions as influenced by interactions with beta-lactoglobulin
    Aiqian Ye
    Riddet Centre, Massey University, Private Bag 11 222, Palmerston North, New Zealand
    J Colloid Interface Sci 295:249-54. 2006
    Oil-in-water emulsions (pH 7.0 or pH 3.0) containing 30 wt% soya oil and various concentrations of lactoferrin were made in a two-stage valve homogenizer...
  93. pmc Induction of lactoferrin gene expression in myeloid or mammary gland cells by human T-cell leukemia virus type 1 (HTLV-1) tax: implications for milk-borne transmission of HTLV-1
    Masako Moriuchi
    Deparment of Molecular Microbiology and Immunology, Division of Medical Virology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
    J Virol 80:7118-26. 2006
    ..We have previously demonstrated that lactoferrin, a major milk protein, enhances HTLV-1 replication, at least in part by upregulating the HTLV-1 long terminal ..
  94. ncbi Crystal structure of human seminal diferric lactoferrin at 3.4 Angstrom resolution
    Janesh Kumar
    Department of Biophysics, All India Institute of Medical Sciences, New Delhi 110029, India
    Indian J Biochem Biophys 40:14-21. 2003
    b>Lactoferrin was purified from human seminal fluid obtained from the semen bank. The purified samples were saturated with Fe3+ and crystallized by microdialysis method. The crystals belong to orthorhombic space group P21212, with a = 55...
  95. doi Lactoferricin but not lactoferrin inhibit herpes simplex virus type 2 infection in mice
    Andrey Shestakov
    Department of Rheumatology and Inflammation Research, University of Gothenburg, Sweden
    Antiviral Res 93:340-5. 2012
    We have evaluated the potential of bovine lactoferrin and lactoferricin for their ability to prevent and/or treat genital HSV-2 infection in mice...
  96. doi Formation of interfacial milk protein complexation to stabilize oil-in-water emulsions against calcium
    Aiqian Ye
    Riddet Institute, Massey University, Palmerston North 4442, New Zealand
    J Colloid Interface Sci 378:184-90. 2012
    ..soya oil) stabilized by sodium caseinate or whey protein were destabilized in the presence of calcium, whereas lactoferrin-stabilized emulsion was stable under same conditions...
  97. doi Identification of lactoferrin peptides generated by digestion with human gastrointestinal enzymes
    C B Furlund
    Department of Chemistry, Biotechnology and Food Science, Norwegian University of Life Sciences, 1432 As, Norway
    J Dairy Sci 96:75-88. 2013
    b>Lactoferrin (LF) is a protein present in milk and other body fluids that plays important biological roles. As part of a diet, LF must survive gastrointestinal conditions or create bioactive fragments to exert its effects...
  98. doi Lactoferrin and its hydrolysate bind directly to the oleate-activated form of the lipolysis stimulated lipoprotein receptor
    Nazir Ahmad
    Université de Lorraine, Unité de Recherche Animal et Fonctionnalités des Produits Animaux, Vandœuvre les Nancy cedex, France
    FEBS J 279:4361-73. 2012
    ..The milk protein, lactoferrin, has been shown to inhibit hepatic chylomicron remnant removal by the liver, resulting in increased ..
  99. doi Polymorphisms in the bovine lactoferrin promoter are associated with reproductive performance and somatic cell count
    F O'Halloran
    Teagasc, Moorepark Food Research Centre, Fermoy, Co Cork, Ireland
    J Dairy Sci 93:1253-9. 2010
    b>Lactoferrin plays an important role in the innate immune system, with well-characterized antibacterial, antiviral, and immune modulatory properties...
  100. pmc Flagellum-mediated biofilm defense mechanisms of Pseudomonas aeruginosa against host-derived lactoferrin
    Jeff G Leid
    Department of Biological Sciences, Northern Arizona University, Flagstaff, Arizona 86001, USA
    Infect Immun 77:4559-66. 2009
    ..a cytokine cross talk network between mononuclear cells and neutrophils that was essential to the production of lactoferrin and bacterial killing...
  101. doi Lactoferrin increases (172Thr)AMPK phosphorylation and insulin-induced (p473Ser)AKT while impairing adipocyte differentiation
    J M Moreno-Navarrete
    Unit of Diabetes, Endocrinology and Nutrition Unit, Biomedical Research Institute of Girona, Hospital de Girona Dr Josep Trueta, and CIBER Fisiopatologia Obesidad y Nutricion CB06 03 010 Instituto de Salud Carlos III, Girona, Spain
    Int J Obes (Lond) 33:991-1000. 2009
    b>Lactoferrin is a pleiotropic glycoprotein of the innate immune system with known effects on immunomodulation and cell differentiation...

Research Grants83

  1. HEMIN UTILIZATION BY P GINGIVALIS
    Caroline Genco; Fiscal Year: 1999
    ..Iron sources will include iron bound to transferrin, lactoferrin, albumin, haptoglobin and hemopexin, sources commonly found in vivo...
  2. Recombinant Lactoferrin and Necrotizing Enterocolitis
    Karel Petrak; Fiscal Year: 2004
    This feasibility study is based on our hypothesis that recombinant human lactoferrin [rhLF] can prevent or reduce severity of necrotizing enterocolitis [NEC]. NEC is mainly a disease of very low birth weight [VLBW] human infants...
  3. IRON ACQUISITION IN BORDETELLA PERTUSSIS
    SANDRA KAY ARMSTRONG; Fiscal Year: 2010
    ..means by which Bordetella cells use host neuroendocrine stress hormones to obtain the iron from transferrin and lactoferrin. PUBLIC HEALTH RELEVANCE: Nearly all bacteria require iron for growth and pathogenic bacteria must be able ..
  4. REGULATION OF GRANULOCYTE SECRETION
    Laurence Boxer; Fiscal Year: 1993
    ..leukocytes (PMN), the NADPH oxidase can be assembled on specific granule (SG) membranes which contain lactoferrin (LF) and cytochrome b558...
  5. Iron acquisition systems in Neisseria gonorrhoeae
    CYNTHIA CORNELISSEN; Fiscal Year: 2007
    ..Although mechanisms for utilization of host iron-binding proteins, including transferrin and lactoferrin, have been most thoroughly characterized, expression of these receptors is not required for growth of the ..
  6. Localized Aggressive Periodontitis: Microbial & Host Markers for Susceptibility
    Daniel Fine; Fiscal Year: 2009
    ..These factors include: iron-saturation of lactoferrin, IgA antibody titers to Aa adhesins, a Growth Modifying Factor (GMF) that killls Gram+ pioneer plaque microbes ..
  7. Localized Aggressive Periodontitis: Microbial & Host Markers for Susceptibility
    Daniel H Fine; Fiscal Year: 2010
    ..These factors include: iron-saturation of lactoferrin, IgA antibody titers to Aa adhesins, a Growth Modifying Factor (GMF) that killls Gram+ pioneer plaque microbes ..
  8. Localized Aggressive Periodontitis: Microbial & Host Markers for Susceptibility
    Daniel Fine; Fiscal Year: 2009
    ..These factors include: iron-saturation of lactoferrin, IgA antibody titers to Aa adhesins, a Growth Modifying Factor (GMF) that killls Gram+ pioneer plaque microbes ..
  9. Formula with antimicrobials to decrease infant mortality
    Koteswara Chintalacharuvu; Fiscal Year: 2006
    ..S-IgA, lactoferrin and lysozyme in breast milk are the major antimicrobial factors...
  10. Structure/function studies of lactoferrin as a protease
    Andrew Plaut; Fiscal Year: 2005
    DESCRIPTION: We have recently discovered that human lactoferrin, a member of the lactotransferrin family of iron binding proteins, has proteolytic activity...
  11. A TRANSCRIPTIONAL PROGRAM REGULATING MYELOPOIESIS
    Alan Friedman; Fiscal Year: 2004
    ..32D cl3 myeloid cells were developed expressing C/EBPa-ER or PU.1-ER. Activation of C/EBPa-ER increased MPO, lactoferrin, and G-CSF receptor mRNA expression and induced a neutrophilic morphology and a G1 cell cycle arrest...
  12. CDP/CUT AND MYELOID DIFFERENTIATION
    Nancy Berliner; Fiscal Year: 2001
    ..We have identified a region within the human lactoferrin (LF) gene promoter which confers a silencing effect on the expression of reporter gene plasmids in LF non-..
  13. PspA: A Potential Pneumococcal Vaccine Component
    David E Briles; Fiscal Year: 2010
    ..PspA also keeps apolactoferrin from killing Sp by neutralizing lactoferrin and its cationic peptide lactoferricin...
  14. Iron acquisition mechanisms utilized by Neisseria gonorrhoeae
    Cynthia Nau Cornelissen; Fiscal Year: 2010
    ..iron from a variety of host-specific sources, including from the iron-binding glycoproteins, transferrin and lactoferrin. Iron transport from these iron-binding proteins is accomplished by an integral, outer membrane transporter, ..
  15. PspA: A Potential Pneumococcal Vaccine Component
    David Briles; Fiscal Year: 2009
    ..PspA also keeps apolactoferrin from killing Sp by neutralizing lactoferrin and its cationic peptide lactoferricin...
  16. PspA: A Potential Pneumococcal Vaccine Component
    David Briles; Fiscal Year: 2009
    ..PspA also keeps apolactoferrin from killing Sp by neutralizing lactoferrin and its cationic peptide lactoferricin...
  17. Bioactivity and Vitamins in Flash-heated Breastmilk
    Caroline Chantry; Fiscal Year: 2005
    ..1) vitamin content and protein digestibility; 2) key bioactive proteins (immunoglobulin A, lysozyme and lactoferrin); 3) antibacterial activity...
  18. Mammalian Lactoferrin Receptors: Structure and Function
    Bo Lonnerdal; Fiscal Year: 2007
    b>Lactoferrin (Lf), an 80 kD glycoprotein that can bind two atoms of Fe(lll), is a major protein in human milk, and also present in exocrine secretions, e.g. pancreatic fluid and bile, and in neutrophils...