L1CAM

Summary

Gene Symbol: L1CAM
Description: L1 cell adhesion molecule
Alias: CAML1, CD171, HSAS, HSAS1, MASA, MIC5, N-CAM-L1, N-CAML1, NCAM-L1, S10, SPG1, neural cell adhesion molecule L1, antigen identified by monoclonal antibody R1
Species: human
Products:     L1CAM

Top Publications

  1. Gavert N, Ben Shmuel A, Raveh S, Ben Ze ev A. L1-CAM in cancerous tissues. Expert Opin Biol Ther. 2008;8:1749-57 pubmed
    ..These results, in addition to the presence of L1-CAM on the cell surface and its restricted distribution in normal tissues, make it an ideal target for tumor therapy. ..
  2. Friedli A, Fischer E, Novak Hofer I, Cohrs S, Ballmer Hofer K, Schubiger P, et al. The soluble form of the cancer-associated L1 cell adhesion molecule is a pro-angiogenic factor. Int J Biochem Cell Biol. 2009;41:1572-80 pubmed publisher
    ..These results indicate an important role of released L1 in tumor angiogenesis and represent a novel function of antibody chCE7 in tumor therapy. ..
  3. Gast D, Riedle S, Issa Y, Pfeifer M, Beckhove P, Sanderson M, et al. The cytoplasmic part of L1-CAM controls growth and gene expression in human tumors that is reversed by therapeutic antibodies. Oncogene. 2008;27:1281-9 pubmed
    ..These findings provide a rationale for the mode of action of L1 antibodies and suggest that interference with L1 function could become a valuable target for therapy. ..
  4. Tyukhtenko S, Deshmukh L, Kumar V, Lary J, Cole J, Lemmon V, et al. Characterization of the neuron-specific L1-CAM cytoplasmic tail: naturally disordered in solution it exercises different binding modes for different adaptor proteins. Biochemistry. 2008;47:4160-8 pubmed publisher
  5. Gouveia R, Gomes C, Sousa M, Alves P, Costa J. Kinetic analysis of L1 homophilic interaction: role of the first four immunoglobulin domains and implications on binding mechanism. J Biol Chem. 2008;283:28038-47 pubmed publisher
    ..Furthermore, they are compatible with a cooperative interaction between modules Ig1-Ig4 in a horseshoe conformation. ..
  6. Reid R, Hemperly J. Variants of human L1 cell adhesion molecule arise through alternate splicing of RNA. J Mol Neurosci. 1992;3:127-35 pubmed
    ..This segment is encoded by a single exon that can be alternately spliced to give rise to the two forms, which appear to be expressed in tissue-specific patterns. ..
  7. Kiefel H, Bondong S, Hazin J, Ridinger J, Schirmer U, Riedle S, et al. L1CAM: a major driver for tumor cell invasion and motility. Cell Adh Migr. 2012;6:374-84 pubmed publisher
    The L1 cell adhesion molecule (L1CAM) plays a major role in the development of the nervous system and in the malignancy of human tumors...
  8. Gavert N, Sheffer M, Raveh S, Spaderna S, Shtutman M, Brabletz T, et al. Expression of L1-CAM and ADAM10 in human colon cancer cells induces metastasis. Cancer Res. 2007;67:7703-12 pubmed
    ..These results indicate that there is a gene program induced by L1-CAM in colon cancer cells that is also present in colorectal cancer tissue and suggest that L1-CAM can serve as target for colon cancer therapy. ..
  9. Geismann C, Morscheck M, Koch D, Bergmann F, Ungefroren H, Arlt A, et al. Up-regulation of L1CAM in pancreatic duct cells is transforming growth factor beta1- and slug-dependent: role in malignant transformation of pancreatic cancer. Cancer Res. 2009;69:4517-26 pubmed publisher
    ..Previously, we observed high expression of the adhesion molecule L1CAM (CD171) in PDAC cells accounting for chemoresistance...

More Information

Publications83

  1. Ito T, Yamada S, Tanaka C, Ito S, Murai T, Kobayashi D, et al. Overexpression of L1CAM is associated with tumor progression and prognosis via ERK signaling in gastric cancer. Ann Surg Oncol. 2014;21:560-8 pubmed publisher
    L1 cell adhesion molecule (L1CAM), which belongs to the immunoglobulin superfamily, has recently been observed in a variety of human malignancies. However, its clinical implication in gastric cancer remains unclear...
  2. Marx M, Diestel S, Bozon M, Keglowich L, Drouot N, Bouché E, et al. Pathomechanistic characterization of two exonic L1CAM variants located in trans in an obligate carrier of X-linked hydrocephalus. Neurogenetics. 2012;13:49-59 pubmed publisher
    Mutations in the gene encoding the neural cell adhesion molecule L1CAM cause several neurological disorders collectively referred to as L1 syndrome...
  3. Kiefel H, Pfeifer M, Bondong S, Hazin J, Altevogt P. Linking L1CAM-mediated signaling to NF-?B activation. Trends Mol Med. 2011;17:178-87 pubmed publisher
    The cell adhesion molecule L1 (L1CAM) was originally identified as a neural adhesion molecule essential for neurite outgrowth and axon guidance...
  4. Grage Griebenow E, Jerg E, Gorys A, Wicklein D, Wesch D, Freitag Wolf S, et al. L1CAM promotes enrichment of immunosuppressive T cells in human pancreatic cancer correlating with malignant progression. Mol Oncol. 2014;8:982-97 pubmed publisher
    ..Likewise, the adhesion molecule L1CAM is upregulated during PDAC progression in the pancreatic ductal epithelium also being associated with poor ..
  5. Kamiguchi H, Lemmon V. A neuronal form of the cell adhesion molecule L1 contains a tyrosine-based signal required for sorting to the axonal growth cone. J Neurosci. 1998;18:3749-56 pubmed
    The neural cell adhesion molecule L1, which is present on axons and growth cones, plays a crucial role in the formation of major axonal tracts such as the corticospinal tract and corpus callosum...
  6. Stoeck A, Schlich S, Issa Y, Gschwend V, Wenger T, Herr I, et al. L1 on ovarian carcinoma cells is a binding partner for Neuropilin-1 on mesothelial cells. Cancer Lett. 2006;239:212-26 pubmed
    ..The L1-NRP-1 binding pathway could contribute to the growth of ovarian carcinomas and to reciprocal signalling between mesothelial cells and tumors. ..
  7. Held Feindt J, Schmelz S, Hattermann K, Mentlein R, Mehdorn H, Sebens S. The neural adhesion molecule L1CAM confers chemoresistance in human glioblastomas. Neurochem Int. 2012;61:1183-91 pubmed publisher
    ..GBM tissues exhibit elevated expression of the transforming growth factor-beta1 (TGF-?1) and the adhesion molecule L1CAM. This study investigated the mechanism of L1CAM regulation in GBM cells and its role in the mediation of ..
  8. Itoh K, Fujisaki K, Watanabe M. Human L1CAM carrying the missense mutations of the fibronectin-like type III domains is localized in the endoplasmic reticulum and degraded by polyubiquitylation. J Neurosci Res. 2011;89:1637-45 pubmed publisher
    Any mutations in the human neural cell adhesion molecule L1 (hL1CAM) gene might cause various types of serious neurological syndromes in humans, characterized by increased mortality, mental retardation, and various malformations of the ..
  9. Kaifi J, Reichelt U, Quaas A, Schurr P, Wachowiak R, Yekebas E, et al. L1 is associated with micrometastatic spread and poor outcome in colorectal cancer. Mod Pathol. 2007;20:1183-90 pubmed
    ..It may have a role in early metastatic spread, as L1 is associated with micrometastases to both the lymph nodes and bone marrow. Thus, L1 should be explored further as a target for adjuvant therapy for micrometastatic disease. ..
  10. Olive S, Dubois C, Schachner M, Rougon G. The F3 neuronal glycosylphosphatidylinositol-linked molecule is localized to glycolipid-enriched membrane subdomains and interacts with L1 and fyn kinase in cerebellum. J Neurochem. 1995;65:2307-17 pubmed
    ..More important is that our study provides information on the molecular machinery likely to be involved in F3 signaling. ..
  11. Finas D, Huszar M, Agic A, Dogan S, Kiefel H, Riedle S, et al. L1 cell adhesion molecule (L1CAM) as a pathogenetic factor in endometriosis. Hum Reprod. 2008;23:1053-62 pubmed publisher
    ..The L1 cell adhesion molecule (L1CAM) is over expressed in ovarian and endometrial carcinomas and is associated with a bad prognosis...
  12. Hlavin M, Lemmon V. Molecular structure and functional testing of human L1CAM: an interspecies comparison. Genomics. 1991;11:416-23 pubmed
    ..We have also cloned and sequenced the entire coding region of human L1CAM and found that it shows a very high degree of homology to mouse L1cam, with 92% identity at the amino acid level...
  13. Okamoto N, Del Maestro R, Valero R, Monros E, Poo P, Kanemura Y, et al. Hydrocephalus and Hirschsprung's disease with a mutation of L1CAM. J Hum Genet. 2004;49:334-7 pubmed
    Abnormalities of the L1CAM gene, a member of the immunoglobulin gene superfamily of neural-cell adhesion molecules, are associated with X-linked hydrocephalus and some allelic disorders...
  14. Schäfer M, Altevogt P. L1CAM malfunction in the nervous system and human carcinomas. Cell Mol Life Sci. 2010;67:2425-37 pubmed publisher
    ..Mutations of the human L1CAM gene have been shown to cause neurodevelopmental disorders such as X-linked hydrocephalus, spastic paraplegia and ..
  15. Kaifi J, Strelow A, Schurr P, Reichelt U, Yekebas E, Wachowiak R, et al. L1 (CD171) is highly expressed in gastrointestinal stromal tumors. Mod Pathol. 2006;19:399-406 pubmed
    ..L1 cell adhesion molecule (CD171) plays an essential role in tumor progression...
  16. Min J, Kim J, Li S, Lee J, Yoon H, Ryu C, et al. L1 cell adhesion molecule is a novel therapeutic target in intrahepatic cholangiocarcinoma. Clin Cancer Res. 2010;16:3571-80 pubmed publisher
    ..We identified that L1 is expressed in ICC. L1 plays an important role in the tumor progression of ICC by enhancing cell proliferation, migration, invasion, and survival. L1 may represent a novel therapeutic target for ICC. ..
  17. Fransen E, Van Camp G, Vits L, Willems P. L1-associated diseases: clinical geneticists divide, molecular geneticists unite. Hum Mol Genet. 1997;6:1625-32 pubmed
    The neuronal cell adhesion molecule L1 (L1CAM) is a transmembrane glycoprotein belonging to the immunoglobulin superfamily and is essential in the development of the nervous system...
  18. Dickson T, Mintz C, Benson D, Salton S. Functional binding interaction identified between the axonal CAM L1 and members of the ERM family. J Cell Biol. 2002;157:1105-12 pubmed
    ..Together, our data indicate that L1 binds directly to members of the ERM family and suggest this association may coordinate aspects of axonal morphogenesis. ..
  19. Schirmer U, Doberstein K, Rupp A, Bretz N, Wuttig D, Kiefel H, et al. Role of miR-34a as a suppressor of L1CAM in endometrial carcinoma. Oncotarget. 2014;5:462-72 pubmed
    b>L1CAM promotes cell motility, invasion and metastasis formation in various human cancers and can be considered as a driver of tumor progression...
  20. Wong E, Schaefer A, Landreth G, Lemmon V. Involvement of p90rsk in neurite outgrowth mediated by the cell adhesion molecule L1. J Biol Chem. 1996;271:18217-23 pubmed
    ..These data demonstrate that the membrane-proximal 15 amino acids of the cytoplasmic domain of L1 are important for neurite outgrowth on L1, and the interactions it mediates may be regulated by phosphorylation of Ser1152. ..
  21. Cheng L, Itoh K, Lemmon V. L1-mediated branching is regulated by two ezrin-radixin-moesin (ERM)-binding sites, the RSLE region and a novel juxtamembrane ERM-binding region. J Neurosci. 2005;25:395-403 pubmed
    We investigated how the neural cell adhesion molecule L1 mediates neurite outgrowth through L1-L1 homophilic interactions...
  22. Islam R, Kristiansen L, Romani S, Garcia Alonso L, Hortsch M. Activation of EGF receptor kinase by L1-mediated homophilic cell interactions. Mol Biol Cell. 2004;15:2003-12 pubmed
    ..Thus L1-type CAMs are able to promote the adhesion-dependent activation of EGF receptor signaling in vitro and in vivo. ..
  23. Fransen E, Lemmon V, Van Camp G, Vits L, Coucke P, Willems P. CRASH syndrome: clinical spectrum of corpus callosum hypoplasia, retardation, adducted thumbs, spastic paraparesis and hydrocephalus due to mutations in one single gene, L1. Eur J Hum Genet. 1995;3:273-84 pubmed
    ..We review here the evidence that several X-linked mental retardation syndromes including X-linked hydrocephalus (HSAS), MASA syndrome, X-linked complicated spastic paraparesis (SP1) and X-linked corpus callosum agenesis (ACC) are all ..
  24. Mikulak J, Negrini S, Klajn A, D Alessandro R, Mavilio D, Meldolesi J. Dual REST-dependence of L1CAM: from gene expression to alternative splicing governed by Nova2 in neural cells. J Neurochem. 2012;120:699-709 pubmed publisher
    L1 cell adhesion molecule (L1CAM), an adhesion/signaling protein encoded by a gene target of the transcription repressor RE-1-Silencing Transcription factor (REST), is expressed in two alternatively spliced isoforms...
  25. Kajiwara Y, Ueno H, Hashiguchi Y, Shinto E, Shimazaki H, Mochizuki H, et al. Expression of l1 cell adhesion molecule and morphologic features at the invasive front of colorectal cancer. Am J Clin Pathol. 2011;136:138-44 pubmed publisher
    ..between morphologic features in the invasive fronts of colorectal cancer (CRC) and L1 cell adhesion molecule (L1CAM) expression, 275 CRCs were assessed with L1CAM immunostaining and 29 CRCs were examined for L1CAM messenger RNA (..
  26. Kanemura Y, Okamoto N, Sakamoto H, Shofuda T, Kamiguchi H, Yamasaki M. Molecular mechanisms and neuroimaging criteria for severe L1 syndrome with X-linked hydrocephalus. J Neurosurg. 2006;105:403-12 pubmed
    Mutations in the gene that codes for the human neural cell adhesion molecule L1 (L1CAM), are known to cause a wide variety of anomalies, now understood as phenotypic expressions of L1 syndrome...
  27. Jung J, Son Y, Park H, Jeon S, Lee J, Choi S, et al. The cell adhesion molecule L1 promotes gallbladder carcinoma progression in vitro and in vivo. Oncol Rep. 2011;25:945-52 pubmed publisher
    ..Taken together, these results suggest that L1 plays a crucial role in GBC progression and may be a novel therapeutic target in GBC treatment. ..
  28. Basel Vanagaite L, Straussberg R, Friez M, Inbar D, Korenreich L, Shohat M, et al. Expanding the phenotypic spectrum of L1CAM-associated disease. Clin Genet. 2006;69:414-9 pubmed
    Mutations in the L1CAM gene cause neurological abnormalities of variable severity, including congenital hydrocephalus, agenesis of the corpus callosum, spastic paraplegia, bilaterally adducted thumbs, aphasia, and mental retardation...
  29. Nagaraj K, Kristiansen L, Skrzynski A, Castiella C, Garcia Alonso L, Hortsch M. Pathogenic human L1-CAM mutations reduce the adhesion-dependent activation of EGFR. Hum Mol Genet. 2009;18:3822-31 pubmed publisher
    ..Either by reducing or abolishing L1-CAM protein expression, by interfering with L1-CAM's cell surface expression, by reducing L1-CAM's adhesive ability or by impeding further downstream adhesion-dependent signaling processes. ..
  30. Weller S, Gartner J. Genetic and clinical aspects of X-linked hydrocephalus (L1 disease): Mutations in the L1CAM gene. Hum Mutat. 2001;18:1-12 pubmed
    ..The responsible gene, L1CAM, encodes the L1 protein which is a member of the immunoglobulin superfamily of neuronal cell adhesion molecules...
  31. Kato K, Maesawa C, Itabashi T, Fujisawa K, Otsuka K, Kanno S, et al. DNA hypomethylation at the CpG island is involved in aberrant expression of the L1 cell adhesion molecule gene in colorectal cancer. Int J Oncol. 2009;35:467-76 pubmed
    The L1 cell adhesion molecule (L1CAM) has been identified as a target gene of beta-catenin-TCF signaling in colorectal cancer (CRC) and associated with aggressive tumor behavior such as invasion and metastasis...
  32. Parisi M, Kapur R, Neilson I, Hofstra R, Holloway L, Michaelis R, et al. Hydrocephalus and intestinal aganglionosis: is L1CAM a modifier gene in Hirschsprung disease?. Am J Med Genet. 2002;108:51-6 pubmed
    ..aqueductal stenosis and/or agenesis of the corpus callosum has been described in newborn males with mutations in L1CAM, a gene that encodes a neural cell adhesion molecule...
  33. Issa Y, Nummer D, Seibel T, Müerköster S, Koch M, Schmitz Winnenthal F, et al. Enhanced L1CAM expression on pancreatic tumor endothelium mediates selective tumor cell transmigration. J Mol Med (Berl). 2009;87:99-112 pubmed publisher
    L1 cell adhesion molecule (L1CAM) is a transmembrane cell adhesion molecule initially defined as a promigratory molecule in the developing nervous system that appears to be also expressed in some endothelial cells...
  34. Schäfer M, Nam Y, Moumen A, Keglowich L, Bouché E, Küffner M, et al. L1 syndrome mutations impair neuronal L1 function at different levels by divergent mechanisms. Neurobiol Dis. 2010;40:222-37 pubmed publisher
    Mutations in the human L1CAM gene cause neurodevelopmental disorders collectively referred to as L1 syndrome. Here, we investigated cellular pathomechanisms underlying two L1 syndrome mutations, R184Q and W1036L...
  35. Ebeling O, Duczmal A, Aigner S, Geiger C, Schöllhammer S, Kemshead J, et al. L1 adhesion molecule on human lymphocytes and monocytes: expression and involvement in binding to alpha v beta 3 integrin. Eur J Immunol. 1996;26:2508-16 pubmed
    ..MED-B1 cells could also be stained with the 6.L1-Fc fusion protein. Our results suggest that human L1 binds predominantly to alpha v beta 3 and that its presence on leukocytes could be important for adhesion and migration. ..
  36. Rosenthal A, Jouet M, Kenwrick S. Aberrant splicing of neural cell adhesion molecule L1 mRNA in a family with X-linked hydrocephalus. Nat Genet. 1992;2:107-12 pubmed
    ..and enlarged brain ventricles, maps to the same subchromosomal region (Xq28) as the gene for neural cell adhesion molecule L1. We have found novel L1 mRNA species in cells from affected members of a HSAS family containing ..
  37. Wei C, Lee E, Jeon J, Heo Y, Kim S, Jeon Y, et al. Structural mechanism of the antigen recognition by the L1 cell adhesion molecule antibody A10-A3. FEBS Lett. 2011;585:153-8 pubmed publisher
    The L1CAM antibody A10-A3 efficiently reduces tumor growth in a nude mouse model. Here, we describe the crystal structure of the Fab fragment of A10-A3 determined at 2.0 angstrom resolution...
  38. Fogel M, Mechtersheimer S, Huszar M, Smirnov A, Abu Dahi A, Tilgen W, et al. L1 adhesion molecule (CD 171) in development and progression of human malignant melanoma. Cancer Lett. 2003;189:237-47 pubmed
    The L1 adhesion molecule (CD171) plays an important role in axon guidance and cell migration in the nervous system. In the human, L1 is expressed on tumors derived from neurocrest and on certain carcinomas...
  39. Wong E, Schaefer A, Landreth G, Lemmon V. Casein kinase II phosphorylates the neural cell adhesion molecule L1. J Neurochem. 1996;66:779-86 pubmed
    ..These data show that CKII is associated with and able to phosphorylate L1. This phosphorylation may be important in regulating certain aspects of L1 function, such as adhesivity or signal transduction. ..
  40. Meli M, Carrel F, Waibel R, Amstutz H, Crompton N, Jaussi R, et al. Anti-neuroblastoma antibody chCE7 binds to an isoform of L1-CAM present in renal carcinoma cells. Int J Cancer. 1999;83:401-8 pubmed
    ..In normal adult kidney tissue, very low levels of protein expression were found. Northern blot analysis confirmed that in renal carcinoma and neuroblastoma cell lines L1-CAM mRNA levels are correlated with protein expression. ..
  41. Hoja Łukowicz D, Link Lenczowski P, Carpentieri A, Amoresano A, Pochec E, Artemenko K, et al. L1CAM from human melanoma carries a novel type of N-glycan with Gal?1-4Gal?1- motif. Involvement of N-linked glycans in migratory and invasive behaviour of melanoma cells. Glycoconj J. 2013;30:205-25 pubmed publisher
    ..We analysed the N-linked glycans of L1CAM from different stages of melanoma progression, using high-performance liquid chromatography combined with ..
  42. Silletti S, Mei F, Sheppard D, Montgomery A. Plasmin-sensitive dibasic sequences in the third fibronectin-like domain of L1-cell adhesion molecule (CAM) facilitate homomultimerization and concomitant integrin recruitment. J Cell Biol. 2000;149:1485-502 pubmed
  43. Needham L, Thelen K, Maness P. Cytoplasmic domain mutations of the L1 cell adhesion molecule reduce L1-ankyrin interactions. J Neurosci. 2001;21:1490-500 pubmed
  44. Stoeck A, Keller S, Riedle S, Sanderson M, Runz S, Le Naour F, et al. A role for exosomes in the constitutive and stimulus-induced ectodomain cleavage of L1 and CD44. Biochem J. 2006;393:609-18 pubmed
    ..However, it is unknown how cleaved soluble molecules get access to the extracellular space. By analysing L1 (CD171) and CD44 in ovarian carcinoma cells, we show in the present paper that the cleavage induced by ionomycin, APMA (4-..
  45. Haspel J, Grumet M. The L1CAM extracellular region: a multi-domain protein with modular and cooperative binding modes. Front Biosci. 2003;8:s1210-25 pubmed
    b>L1CAM is a neural cell adhesion molecule (CAM) that is critical for proper CNS development in humans...
  46. Schaefer A, Kamei Y, Kamiguchi H, Wong E, Rapoport I, Kirchhausen T, et al. L1 endocytosis is controlled by a phosphorylation-dephosphorylation cycle stimulated by outside-in signaling by L1. J Cell Biol. 2002;157:1223-32 pubmed
    ..Thus, the regulation of L1 endocytosis through dephosphorylation of Y1176 is a critical regulatory point of L1-mediated adhesion and signaling. ..
  47. Yoon H, Min J, Lee D, Kim D, Koh S, Hong H. L1 cell adhesion molecule and epidermal growth factor receptor activation confer cisplatin resistance in intrahepatic cholangiocarcinoma cells. Cancer Lett. 2012;316:70-6 pubmed publisher
    ..Here, we report that epidermal growth factor receptor (EGFR) signaling and L1 cell adhesion molecule (L1CAM) conferred cisplatin resistance in SCK(R) cells in an additive fashion...
  48. Schäfer M, Frotscher M. Role of L1CAM for axon sprouting and branching. Cell Tissue Res. 2012;349:39-48 pubmed publisher
    ..The immunoglobulin superfamily member L1CAM has been shown to promote the capability of neurons for regenerative axon sprouting and to improve behavioral ..
  49. Wolff J, Frank R, Mujoo K, Spiro R, Reisfeld R, Rathjen F. A human brain glycoprotein related to the mouse cell adhesion molecule L1. J Biol Chem. 1988;263:11943-7 pubmed
    ..These findings provide a basis for studying the role of the human L1 homologue in human diseases. ..
  50. Schirmer U, Fiegl H, Pfeifer M, Zeimet A, Muller Holzner E, Bode P, et al. Epigenetic regulation of L1CAM in endometrial carcinoma: comparison to cancer-testis (CT-X) antigens. BMC Cancer. 2013;13:156 pubmed publisher
    b>L1CAM was originally identified as an adhesion molecule involved in neural development. In many human carcinomas L1CAM is over-expressed and is associated with a bad prognosis...
  51. Van Camp G, Fransen E, Vits L, Raes G, Willems P. A locus-specific mutation database for the neural cell adhesion molecule L1CAM (Xq28). Hum Mutat. 1996;8:391 pubmed
  52. Li S, Jo Y, Lee J, Min J, Lee E, Park T, et al. L1 cell adhesion molecule is a novel independent poor prognostic factor of extrahepatic cholangiocarcinoma. Clin Cancer Res. 2009;15:7345-51 pubmed publisher
    ..7% of ECC and its expression was significantly associated with perineural invasion. High expression of L1 and nodal metastasis were independent poor prognostic factors predicting overall survival in patients with ECC. ..
  53. Gavert N, Ben Shmuel A, Lemmon V, Brabletz T, Ben Ze ev A. Nuclear factor-kappaB signaling and ezrin are essential for L1-mediated metastasis of colon cancer cells. J Cell Sci. 2010;123:2135-43 pubmed publisher
    ..The cell-neural adhesion molecule L1CAM (hereafter referred to as L1) is a target of beta-catenin-TCF, exclusively expressed at the CRC invasive front in ..
  54. Schröder C, Schumacher U, Fogel M, Feuerhake F, Muller V, Wirtz R, et al. Expression and prognostic value of L1-CAM in breast cancer. Oncol Rep. 2009;22:1109-17 pubmed
    ..Given the emerging functional role of L1 in promoting tumor cell migration, invasion, tumor growth and metastasis, our results suggest that L1 may have this function in breast cancer as well. ..
  55. Gavert N, Conacci Sorrell M, Gast D, Schneider A, Altevogt P, Brabletz T, et al. L1, a novel target of beta-catenin signaling, transforms cells and is expressed at the invasive front of colon cancers. J Cell Biol. 2005;168:633-42 pubmed
    ..The transmembrane localization and shedding of L1 by metalloproteases could be useful for detection and as target for colon cancer therapy. ..
  56. Godenschwege T, Kristiansen L, Uthaman S, Hortsch M, Murphey R. A conserved role for Drosophila Neuroglian and human L1-CAM in central-synapse formation. Curr Biol. 2006;16:12-23 pubmed
    ..Finally, our findings suggest that some aspects of L1-CAM-related neurological disorders in humans may result from a disruption in synapse formation rather than in axon pathfinding. ..
  57. Vits L, Van Camp G, Coucke P, Fransen E, De Boulle K, Reyniers E, et al. MASA syndrome is due to mutations in the neural cell adhesion gene L1CAM. Nat Genet. 1994;7:408-13 pubmed
    ..Since it has been shown that X-linked hydrocephalus can be caused by mutations in L1CAM, a neuronal cell adhesion molecule, we performed an L1CAM mutation analysis in eight unrelated patients with MASA ..
  58. Meier F, Busch S, Gast D, Göppert A, Altevogt P, Maczey E, et al. The adhesion molecule L1 (CD171) promotes melanoma progression. Int J Cancer. 2006;119:549-55 pubmed
    ..Altogether, L1 plays a critical role in melanoma invasion and progression and offers therapeutic potential in combination with conventional anticancer agents. ..
  59. Boo Y, Park J, Kim J, Chae Y, Min B, Um J, et al. L1 expression as a marker for poor prognosis, tumor progression, and short survival in patients with colorectal cancer. Ann Surg Oncol. 2007;14:1703-11 pubmed
    ..L1 expression is associated with tumor progression and poor survival in patients with colorectal cancer and may be clinically useful as a marker for poor prognosis. ..
  60. Coutelle O, Nyakatura G, Taudien S, Elgar G, Brenner S, Platzer M, et al. The neural cell adhesion molecule L1: genomic organisation and differential splicing is conserved between man and the pufferfish Fugu. Gene. 1998;208:7-15 pubmed
    The human gene for the neural cell adhesion molecule L1 is located on Xq28 between the ALD and MeCP2 loci...
  61. Scotland P, Zhou D, Benveniste H, Bennett V. Nervous system defects of AnkyrinB (-/-) mice suggest functional overlap between the cell adhesion molecule L1 and 440-kD AnkyrinB in premyelinated axons. J Cell Biol. 1998;143:1305-15 pubmed
    ..These findings provide the first evidence for a role of ankyrinB in the nervous system and support an interaction between 440-kD ankyrinB and L1 that is essential for maintenance of premyelinated axons in vivo. ..
  62. Zeimet A, Reimer D, Huszar M, Winterhoff B, Puistola U, Azim S, et al. L1CAM in early-stage type I endometrial cancer: results of a large multicenter evaluation. J Natl Cancer Inst. 2013;105:1142-50 pubmed publisher
    ..We analyzed the value of immunohistochemical L1CAM determination to predict clinical outcome...
  63. Fryns J, Spaepen A, Cassiman J, Van den Berghe H. X linked complicated spastic paraplegia, MASA syndrome, and X linked hydrocephalus owing to congenital stenosis of the aqueduct of Sylvius: variable expression of the same mutation at Xq28. J Med Genet. 1991;28:429-31 pubmed
  64. Kiefel H, Bondong S, Pfeifer M, Schirmer U, Erbe Hoffmann N, Schäfer H, et al. EMT-associated up-regulation of L1CAM provides insights into L1CAM-mediated integrin signalling and NF-?B activation. Carcinogenesis. 2012;33:1919-29 pubmed publisher
    Expression of L1 cell adhesion molecule (L1CAM) is associated with poor prognosis in a variety of human carcinomas including breast, ovarian and pancreatic ductal adenocarcinoma (PDAC)...
  65. Bondong S, Kiefel H, Hielscher T, Zeimet A, Zeillinger R, Pils D, et al. Prognostic significance of L1CAM in ovarian cancer and its role in constitutive NF-?B activation. Ann Oncol. 2012;23:1795-802 pubmed publisher
    Overexpression of L1-cell adhesion molecule (L1CAM) has been observed for various carcinomas and correlates with poor prognosis and late-stage disease. In vitro, L1CAM enhances proliferation, cell migration, adhesion and chemoresistance...
  66. Djabali M, Mattei M, Nguyen C, Roux D, Demengeot J, Denizot F, et al. The gene encoding L1, a neural adhesion molecule of the immunoglobulin family, is located on the X chromosome in mouse and man. Genomics. 1990;7:587-93 pubmed
    ..This location is compatible with the implication of the L1 molecule in one of the X-linked neuromuscular diseases mapped to this region. ..
  67. Kulahin N, Li S, Hinsby A, Kiselyov V, Berezin V, Bock E. Fibronectin type III (FN3) modules of the neuronal cell adhesion molecule L1 interact directly with the fibroblast growth factor (FGF) receptor. Mol Cell Neurosci. 2008;37:528-36 pubmed publisher
    ..Furthermore, ATP modulated L1-induced neuronal differentiation and FGFR1 phosphorylation through regulation of the L1-FGFR1 interaction. ..
  68. Gast D, Riedle S, Kiefel H, Müerköster S, Schäfer H, Schäfer M, et al. The RGD integrin binding site in human L1-CAM is important for nuclear signaling. Exp Cell Res. 2008;314:2411-8 pubmed publisher
    ..Mutant L1 was unable to translocate to the nucleus. Our findings highlight the importance of the RGD site in L1 for human tumors and suggest that nuclear signaling of L1 is dependent on integrins. ..
  69. Choi S, Jo Y, Huang S, Liang Z, Min J, Hong H, et al. L1 cell adhesion molecule as a novel independent poor prognostic factor in gallbladder carcinoma. Hum Pathol. 2011;42:1476-83 pubmed publisher
    ..Taken together, our findings suggest that L1 cell adhesion molecule expression could be used as a novel prognostic factor for patient survival and might be a potential therapeutic target in gallbladder carcinomas. ..
  70. Jouet M, Rosenthal A, Armstrong G, Macfarlane J, Stevenson R, Paterson J, et al. X-linked spastic paraplegia (SPG1), MASA syndrome and X-linked hydrocephalus result from mutations in the L1 gene. Nat Genet. 1994;7:402-7 pubmed
    ..We have previously shown that X-linked hydrocephalus is caused by mutations in the gene for neural cell adhesion molecule L1 (L1CAM), an axonal glycoprotein involved in neuronal migration and differentiation...
  71. Rawnaq T, Quaas A, Zander H, Gros S, Reichelt U, Blessmann M, et al. L1 is highly expressed in tumors of the nervous system: a study of over 8000 human tissues. J Surg Res. 2012;173:314-9 pubmed publisher
    L1 cell adhesion molecule (CD171) has been detected in different malignant tumors and is associated with unfavorable outcome. It thus represents a target for tumor diagnosis and therapy...
  72. Bao S, Wu Q, Li Z, Sathornsumetee S, Wang H, McLendon R, et al. Targeting cancer stem cells through L1CAM suppresses glioma growth. Cancer Res. 2008;68:6043-8 pubmed publisher
    ..We interrogated the role of a neuronal cell adhesion molecule, L1CAM, in glioma stem cells as L1CAM regulates brain development and is expressed in gliomas...
  73. Silletti S, Yebra M, Perez B, Cirulli V, McMahon M, Montgomery A. Extracellular signal-regulated kinase (ERK)-dependent gene expression contributes to L1 cell adhesion molecule-dependent motility and invasion. J Biol Chem. 2004;279:28880-8 pubmed
    ..This study provides a novel translational mechanism to account for the association between L1 expression and motile processes involved in metastasis and development. ..
  74. Pfeifer M, Schirmer U, Geismann C, Schäfer H, Sebens S, Altevogt P. L1CAM expression in endometrial carcinomas is regulated by usage of two different promoter regions. BMC Mol Biol. 2010;11:64 pubmed publisher
    The L1 cell adhesion molecule (L1CAM) was originally identified as a neural adhesion molecule involved in axon guidance...