Kv1.1

Summary

Gene Symbol: Kv1.1
Description: potassium voltage-gated channel, shaker-related subfamily, member 1 (episodic ataxia with myokymia)
Alias: AEMK, EA1, HBK1, HUK1, KV1.1, MBK1, MK1, RBK1, potassium voltage-gated channel subfamily A member 1, voltage-gated K(+) channel HuKI, voltage-gated potassium channel HBK1, voltage-gated potassium channel subunit Kv1.1
Species: human

Top Publications

  1. pmc Voltage-gated K+ channels in rat small cerebral arteries: molecular identity of the functional channels
    Sulayma Albarwani
    Department of Physiology, College of Medicine, Sultan Qaboos University, Al Khod, Sultanate of Oman
    J Physiol 551:751-63. 2003
  2. pmc Functional coupling of intracellular calcium and inactivation of voltage-gated Kv1.1/Kvbeta1.1 A-type K+ channels
    Flora Jow
    Neuroscience Discovery Research, Wyeth Research, CN 8000, Princeton, NJ 08543, USA
    Proc Natl Acad Sci U S A 101:15535-40. 2004
  3. pmc Low-voltage activated Kv1.1 subunits are crucial for the processing of sound source location in the lateral superior olive in mice
    Anita Karcz
    Institute of Biology, Faculty of Biosciences, Pharmacy and Psychology, University of Leipzig, Talstrasse 33, 04103 Leipzig, Germany
    J Physiol 589:1143-57. 2011
  4. ncbi Episodic ataxia/myokymia syndrome is associated with point mutations in the human potassium channel gene, KCNA1
    D L Browne
    Department of Biochemistry and Molecular Biology, Oregon Health Sciences University, Portland 97201
    Nat Genet 8:136-40. 1994
  5. pmc Nerve excitability studies characterize Kv1.1 fast potassium channel dysfunction in patients with episodic ataxia type 1
    Susan E Tomlinson
    Institute of Neurology, University College London, London WC1N 3BG, UK
    Brain 133:3530-40. 2010
  6. ncbi Expanding the phenotype of potassium channelopathy: severe neuromyotonia and skeletal deformities without prominent Episodic Ataxia
    M Kinali
    Dubowitz Neuromuscular Centre, Hammersmith Hospital, Imperial College School of Medicine, London, UK
    Neuromuscul Disord 14:689-93. 2004
  7. ncbi Clinical, genetic, and expression studies of mutations in the potassium channel gene KCNA1 reveal new phenotypic variability
    L H Eunson
    University Department of Clinical Neurology, Institute of Neurology University College of London, Queen Square, UK
    Ann Neurol 48:647-56. 2000
  8. ncbi A novel mutation in the human voltage-gated potassium channel gene (Kv1.1) associates with episodic ataxia type 1 and sometimes with partial epilepsy
    S M Zuberi
    Department of Neurology and Child Development, Royal Hospital for Sick Children, Glasgow, UK
    Brain 122:817-25. 1999
  9. ncbi Nervous system targets of RNA editing identified by comparative genomics
    Barry Hoopengardner
    Department of Genetics and Developmental Biology, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030, USA
    Science 301:832-6. 2003
  10. pmc The human Kv1.1 channel is palmitoylated, modulating voltage sensing: Identification of a palmitoylation consensus sequence
    Rose A Gubitosi-Klug
    Division of Bioorganic Chemistry and Molecular Pharmacology, Department of Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 102:5964-8. 2005

Detail Information

Publications160 found, 100 shown here

  1. pmc Voltage-gated K+ channels in rat small cerebral arteries: molecular identity of the functional channels
    Sulayma Albarwani
    Department of Physiology, College of Medicine, Sultan Qaboos University, Al Khod, Sultanate of Oman
    J Physiol 551:751-63. 2003
    ..The findings of this study suggest that KV1.2/1.5 heterotetramers are preferentially expressed in rat cerebral VSMCs, and that these channels contribute to the resting membrane potential and diameter of rat small cerebral arteries...
  2. pmc Functional coupling of intracellular calcium and inactivation of voltage-gated Kv1.1/Kvbeta1.1 A-type K+ channels
    Flora Jow
    Neuroscience Discovery Research, Wyeth Research, CN 8000, Princeton, NJ 08543, USA
    Proc Natl Acad Sci U S A 101:15535-40. 2004
    ....
  3. pmc Low-voltage activated Kv1.1 subunits are crucial for the processing of sound source location in the lateral superior olive in mice
    Anita Karcz
    Institute of Biology, Faculty of Biosciences, Pharmacy and Psychology, University of Leipzig, Talstrasse 33, 04103 Leipzig, Germany
    J Physiol 589:1143-57. 2011
    ..These results imply a fundamental role for Kv1.1 in temporal integration of excitation and inhibition during sound source localization...
  4. ncbi Episodic ataxia/myokymia syndrome is associated with point mutations in the human potassium channel gene, KCNA1
    D L Browne
    Department of Biochemistry and Molecular Biology, Oregon Health Sciences University, Portland 97201
    Nat Genet 8:136-40. 1994
    ..Mutation analysis of the KCNA1 coding region in these families identified four different missense point mutations present in the heterozygous state, indicating that EA/myokymia can result from mutations in this gene...
  5. pmc Nerve excitability studies characterize Kv1.1 fast potassium channel dysfunction in patients with episodic ataxia type 1
    Susan E Tomlinson
    Institute of Neurology, University College London, London WC1N 3BG, UK
    Brain 133:3530-40. 2010
    ..1 dysfunction in patients with episodic ataxia type 1. The simple 15 min test may be useful in diagnosis, since it can differentiate patients with episodic ataxia type 1 from normal controls with high sensitivity and specificity...
  6. ncbi Expanding the phenotype of potassium channelopathy: severe neuromyotonia and skeletal deformities without prominent Episodic Ataxia
    M Kinali
    Dubowitz Neuromuscular Centre, Hammersmith Hospital, Imperial College School of Medicine, London, UK
    Neuromuscul Disord 14:689-93. 2004
    ..His mother presented some years later with typical features of Episodic Ataxia type 1 (EA1), with episodes of ataxia lasting a few minutes provoked by exercise...
  7. ncbi Clinical, genetic, and expression studies of mutations in the potassium channel gene KCNA1 reveal new phenotypic variability
    L H Eunson
    University Department of Clinical Neurology, Institute of Neurology University College of London, Queen Square, UK
    Ann Neurol 48:647-56. 2000
    Episodic ataxia type 1 (EA1) is an autosomal dominant central nervous system potassium channelopathy characterized by brief attacks of cerebellar ataxia and continuous interictal myokymia...
  8. ncbi A novel mutation in the human voltage-gated potassium channel gene (Kv1.1) associates with episodic ataxia type 1 and sometimes with partial epilepsy
    S M Zuberi
    Department of Neurology and Child Development, Royal Hospital for Sick Children, Glasgow, UK
    Brain 122:817-25. 1999
    Episodic ataxia type 1 (EA1) is a rare autosomal dominant disorder characterized by brief episodes of ataxia associated with continuous interattack myokymia. Point mutations in the human voltage-gated potassium channel (Kv1...
  9. ncbi Nervous system targets of RNA editing identified by comparative genomics
    Barry Hoopengardner
    Department of Genetics and Developmental Biology, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030, USA
    Science 301:832-6. 2003
    ..These results point to a pivotal role for RNA editing in nervous system function...
  10. pmc The human Kv1.1 channel is palmitoylated, modulating voltage sensing: Identification of a palmitoylation consensus sequence
    Rose A Gubitosi-Klug
    Division of Bioorganic Chemistry and Molecular Pharmacology, Department of Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 102:5964-8. 2005
    ....
  11. ncbi Episodic ataxia and myokymia syndrome: a new mutation of potassium channel gene Kv1.1
    S Comu
    Department of Pediatrics, University of Pittsburgh, PA, USA
    Ann Neurol 40:684-7. 1996
    ..This disease has been associated with point mutations in the potassium channel gene Kv1.1 (KCNA1), located at chromosome 12p13. Here, we describe a novel mutation within this gene in a newly diagnosed family...
  12. ncbi Three novel KCNA1 mutations in episodic ataxia type I families
    H Scheffer
    Department of Medical Genetics, University of Groningen, The Netherlands
    Hum Genet 102:464-6. 1998
    ..By direct sequence analysis, a different missense mutation of the potassium channel gene (KCNA1) has been identified in three families with EA...
  13. ncbi Characterization of the outer pore region of the apamin-sensitive Ca2+-activated K+ channel rSK2
    Heike Jäger
    Department of Applied Physiology, University of Ulm, Albert Einstein Allee 11, 89081 Ulm, Germany
    Toxicon 43:951-60. 2004
    ..From mutant cycle analysis of KTX position H34 and SK2 position V342G, S344E, and G348D we could deduce that KTX binds in a similar way to SK2 channel mutant pore than to the Kv1.1 pore...
  14. ncbi In vivo selection of Enterobacter aerogenes with reduced susceptibility to cefepime and carbapenems associated with decreased expression of a 40 kDa outer membrane protein and hyperproduction of AmpC beta-lactamase
    Felipe Fernandez-Cuenca
    Department of Microbiology, University of Seville, and University Hospital Virgen Macarena, Seville, Spain
    Int J Antimicrob Agents 27:549-52. 2006
    ..susceptibility to cefepime (FEP) and/or imipenem (IMP) in three consecutive isolates of Enterobacter aerogenes (Ea1, Ea2 and Ea3) cultured from bronchial aspirates of the same patient after treatment with ceftriaxone and FEP were ..
  15. ncbi Ataxias with autosomal, X-chromosomal or maternal inheritance
    Josef Finsterer
    Krankenanstalt Rudolfstiftung, Vienna, Austria, Europe
    Can J Neurol Sci 36:409-28. 2009
    ..spinocerebellar ataxias (SCA1-8, 10-15, 17-23, 25-30, and dentato-rubro-pallido-luysian atrophy), episodic ataxias (EA1-7), and autosomal dominant mitochondrial heredoataxias (Leigh syndrome, MIRAS, ADOAD, and AD-CPEO)...
  16. ncbi The abnormal occurrence and the differentiation-dependent distribution of N-acetyl and N-glycolyl species of the ganglioside GM2 in human germ cell tumors. A study with specific monoclonal antibodies
    M Miyake
    Department of Laboratory Medicine and Clinical Science, School of Medicine, Kyoto University, Japan
    Cancer 65:499-505. 1990
    ..specific monoclonal antibodies which can distinguish the molecular species of the sialic acid moiety: the antibody MK1-16 is specific for N-acetyl GM2, MK2-34 is specific for N-glycolyl GM2, and MK1-17 detects both N-acetyl and N-..
  17. ncbi Identification of mK1, a true tissue (glandular) kallikrein of mouse submandibular gland: tissue distribution and a comparison of kinin-releasing activity with other submandibular kallikreins
    K Hosoi
    Department of Oral Physiology, Meikai University School of Dentistry, Saitama
    J Biochem 115:137-43. 1994
    ..The present results revealed that the former proteinase F is identical to mK1, tissue/renal kallikrein, and confirmed its characteristics as a true kallikrein on the basis of its kinin-..
  18. pmc Differences in substrate and inhibitor sequence specificity of human, mouse and rat tissue kallikreins
    Sandro E Fogaça
    Department of Biophysics, Escola Paulista de Medicina, Universidade Federal de Sao Paulo, Rua Tres de Maio 100, São Paulo 04044 20, Brazil
    Biochem J 380:775-81. 2004
    The kininogenase activities of mouse (mK1), rat (rK1) and human (hK1) tissue kallikreins were assayed with the bradykinin-containing synthetic peptides Abz-MTEMARRPPGFSPFRSVTVQNH2 (where Abz stands for o-aminobenzoyl) and Abz-..
  19. pmc Molecular cloning of a glibenclamide-sensitive, voltage-gated potassium channel expressed in rabbit kidney
    X Yao
    Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    J Clin Invest 97:2525-33. 1996
    ..We conclude that rabKv1.3 is a novel member of the Shaker superfamily that may play an important role in renal potassium transport...
  20. pmc Methylamine and benzylamine induced hypophagia in mice: modulation by semicarbazide-sensitive benzylamine oxidase inhibitors and aODN towards Kv1.1 channels
    R Pirisino
    Department of Preclinical and Clinical Pharmacology, Viale Pieraccini, 6, 50134 Florence, Italy
    Br J Pharmacol 134:880-6. 2001
    ..1 blocking activity. Through a reduction of the endogenous breakdown of MET, Bz-SSAO inhibitors enhance the central pharmacological activity of this amine...
  21. ncbi Episodic ataxia type 1 mutations in the KCNA1 gene impair the fast inactivation properties of the human potassium channels Kv1.4-1.1/Kvbeta1.1 and Kv1.4-1.1/Kvbeta1.2
    Paola Imbrici
    University of Perugia School of Medicine, Department of Internal Medicine, Section of Human Physiology, Via del Giochetto, I 06126 Perugia, Italy
    Eur J Neurosci 24:3073-83. 2006
    Episodic ataxia type 1 (EA1) is an autosomal dominant neurological disorder characterized by constant muscle rippling movements (myokymia) and episodic attacks of ataxia...
  22. ncbi The role of Kv1.2-containing potassium channels in serotonin-induced glutamate release from thalamocortical terminals in rat frontal cortex
    E K Lambe
    Interdepartmental Neuroscience Program and Departments of Psychiatry and Pharmacology, Yale University School of Medicine, New Haven Connecticut 06508, USA
    J Neurosci 21:9955-63. 2001
    ..These results indicate that blockade of Kv1.2-containing potassium channels is part of the mechanism underlying 5-HT-induced glutamate release from thalamocortical terminals...
  23. pmc Presynaptic rat Kv1.2 channels suppress synaptic terminal hyperexcitability following action potential invasion
    Paul D Dodson
    Department of Cell Physiology and Pharmacology, University of Leicester, PO Box 138, Leicester LE1 9HN, UK
    J Physiol 550:27-33. 2003
    ..We conclude that Kv1.2 channels have a general presynaptic function in suppressing terminal hyperexcitability during the depolarising after-potential...
  24. ncbi The glycosylation state of Kv1.2 potassium channels affects trafficking, gating, and simulated action potentials
    Itaru Watanabe
    Department of Biological Sciences, Fordham University, Bronx, New York 10458, USA
    Brain Res 1144:1-18. 2007
    ..Thus altering the native Kv1.2 glycosylation state affected its trafficking, gating, and simulated action potentials. Differential glycosylation of ion channels could be used by excitable cells to modify cell signaling...
  25. ncbi Engineering-specific pharmacological binding sites for peptidyl inhibitors of potassium channels into KcsA
    Christian Legros
    Institut für Neurale Signalverarbeitung, ZMNH, Universitat Hamburg, Martinistrasse 52, D 20246 Hamburg, Germany
    Biochemistry 41:15369-75. 2002
    ..X chimeras containing the subregion I of the corresponding mammalian Kv1.X channels. This innovative approach may facilitate the high-throughput screening of ligand libraries aimed at the discovery of novel potassium channel modulators...
  26. ncbi New roles for renal potassium channels
    Carsten A Wagner
    Institute of Physiology and Zurich Center for Integrative Human Physiology, University of Zurich, Zurich, Switzerland
    J Nephrol 23:5-8. 2010
    ..Moreover, defects of 2 different potassium channels expressed on opposing membrane domains of the same cells cause distinct symptoms...
  27. ncbi Role of disulfide bonds in the structure and potassium channel blocking activity of ShK toxin
    M W Pennington
    Bachem Bioscience Inc, 3700 Horizon Drive, King of Prussia, Pennsylvania 19406, USA
    Biochemistry 38:14549-58. 1999
    ..The possible interactions of this analogue with the channel and the distinction between native secondary and tertiary structure on one hand and global topology imposed by the disulfide bridges on the other are discussed...
  28. ncbi Peptidyl inhibitors of shaker-type Kv1 channels elicit twitches in guinea pig ileum by blocking kv1.1 at enteric nervous system and enhancing acetylcholine release
    G Suarez-Kurtz
    Coordenação de Pesquisa, Instituto Nacional de Cancer, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil
    J Pharmacol Exp Ther 289:1517-22. 1999
    ..1. The data taken together suggest that high-affinity blockade of Kv1.1 underlies the ability of MgTX, kaliotoxin, agitoxin-1, agitoxin-2, alpha-dendrotoxin, and stichodactylatoxin to elicit TTX-sensitive twitches in guinea pig ileum...
  29. ncbi Involvement of kv1 potassium channels in spreading acidification and depression in the cerebellar cortex
    Gang Chen
    Department of Neuroscience, University of Minnesota, Minneapolis, MN 55455, USA
    J Neurophysiol 94:1287-98. 2005
    ..The dramatic effects of DTX-K suggest a possible connection between SAD and episodic ataxia type 1 (EA1), a Kv1.1 potassium channelopathy. The threshold for evoking SAD was significantly lowered in the Kv1...
  30. ncbi [Expression and properties of potassium channels in human mammary epithelial cell line MCF10A and its possible role in proliferation]
    Jia Liu
    College of Life Science, Liaoning Normal University, Dalian, China
    Sheng Li Xue Bao 62:203-9. 2010
    ....
  31. pmc A homeobox gene with potential developmental control function in the meristem of the conifer Picea abies
    A Sundås-Larsson
    Department of Physiological Botany, Uppsala University, Villavagen 6, S 752 36, Uppsala, Sweden
    Proc Natl Acad Sci U S A 95:15118-22. 1998
    ..In this report, we describe the first cDNA corresponding to a homeobox gene isolated from a gymnosperm, the HBK1 gene from the conifer Picea abies (L.) Karst (Norway spruce)...
  32. pmc Contribution of Kv1.2 voltage-gated potassium channel to D2 autoreceptor regulation of axonal dopamine overflow
    Stephanie Fulton
    Department of Pharmacology and Groupe de Recherche sur le Système Nerveux Central, Universite de Montreal, Quebec H3C 3J7, Canada
    J Biol Chem 286:9360-72. 2011
    ..2-containing channels in striatal tissue. These findings underline the contribution of Kv1.2 in the regulation of nigrostriatal DA release by the D2-AR and thereby offer a novel mechanism by which DA release is regulated...
  33. ncbi Differential distribution of Shaker-like and Shab-like K+-channel subunits in goldfish retina and retinal bipolar cells
    S Yazulla
    Department of Neurobiology and Behavior, University at Stony Brook, New York 11794 5230, USA
    J Comp Neurol 396:131-40. 1998
    ....
  34. ncbi Role of K(+) channel expression in polyamine-dependent intestinal epithelial cell migration
    J Y Wang
    Department of Surgery, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Am J Physiol Cell Physiol 278:C303-14. 2000
    ..1 channel expression. The subsequent membrane hyperpolarization raises [Ca(2+)](cyt) by increasing the driving force (the electrochemical gradient) for Ca(2+) influx and thus stimulates cell migration...
  35. ncbi Structure-activity relationships of the Kvbeta1 inactivation domain and its putative receptor probed using peptide analogs of voltage-gated potassium channel alpha- and beta-subunits
    S J Lombardi
    Wyeth Ayerst Research, CNS Disorders, Princeton, New Jersey 08543 8000, USA
    J Biol Chem 273:30092-6. 1998
    ..1 alpha subunit is the likely acceptor for the Kvbeta1 inactivation domain and provide information about residues that may underlie the protein-protein interactions responsible for beta-subunit mediated Kv channel inactivation...
  36. pmc Phylogenomic analyses of KCNA gene clusters in vertebrates: why do gene clusters stay intact?
    Simone Hoegg
    Lehrstuhl fur Zoologie und Evolutionsbiologie, Department of Biology, University of Konstanz, 78457 Konstanz, Germany
    BMC Evol Biol 7:139. 2007
    ..Interestingly, this hypothesis does not appear to apply to the KCNA clusters, as too few conserved putative regulatory elements are retained...
  37. ncbi Additive and/or synergistic action (downregulation) of androgens and thyroid hormones on the cellular distribution and localization of a true tissue kallikrein, mK1, in the mouse submandibular gland
    Shingo Kurabuchi
    Dept of Histology, Nippon Dental University School of Dentistry at Tokyo, Fujimi 1 9 20, Chiyoda ku, Tokyo 102 8159, Japan
    J Histochem Cytochem 52:1437-46. 2004
    ..5alpha-dihydrotestosterone (DHT), 3,5,3'-triiodo-l-thyronine (T(3)), and dexamethasone (Dex) on the expression of mK1 in the granular convoluted tubule (GCT) cells of the submandibular gland (SMG) of hypophysectomized (Hypox) male ..
  38. doi Recent advances in the genetics of recurrent vertigo and vestibulopathy
    Joanna C Jen
    Department of Neurology, UCLA School of Medicine, Los Angeles, CA 90095 1769, USA
    Curr Opin Neurol 21:3-7. 2008
    ..To focus on recent advances in the genetics of recurrent vertigo, with an overview on episodic ataxia, benign recurrent vertigo (mainly migraine-associated vertigo), bilateral vestibulopathy, and Ménière's disease...
  39. ncbi Kv1.1/1.2 channels are downstream effectors of nitric oxide on synaptic GABA release to preautonomic neurons in the paraventricular nucleus
    Q Yang
    Department of Anesthesiology and Pain Medicine, Unit 110, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Neuroscience 149:315-27. 2007
    ..These findings suggest that NO increases GABAergic input to PVN presympathetic neurons through a downstream mechanism involving the Kv1.1 and Kv1.2 channels at the nerve terminals...
  40. ncbi Molecular docking of the scorpion toxin Tc1 to the structural model of the voltage-gated potassium channel Kv1.1 from human Homo sapiens
    Hsuan Liang Liu
    Department of Chemical Engineering, Graduate Institute of Biotechnology, National Taipei University of Technology, No 1 Sec 3 Chung Hsiao E Rd, Taipei, Taiwan 10608
    J Biomol Struct Dyn 21:639-50. 2004
    ..1. Furthermore, surface complementarity of the outer vestibules of the channels to the Tc1 spatial conformations also plays an important role in stabilizing both the Tc1/KcsA and Tc1/Kv1.1 complexes...
  41. ncbi Truncation of the Shaker-like voltage-gated potassium channel, Kv1.1, causes megencephaly
    Susanna Petersson
    Neurogenetic Unit, Department of Molecular Medicine, CMM, L8 00, Karolinska Institutet, 171 76 Stockholm, Sweden
    Eur J Neurosci 18:3231-40. 2003
    ..However, in contrast to the commonly demonstrated epilepsy-induced neurodegeneration, we find that the mceph mutation leads to seizures with a concomitant increase in brain size, without overt neural atrophy...
  42. ncbi Sensitivity of native and cloned hippocampal delayed-rectifier potassium channels to verapamil
    M Madeja
    Institut fur Physiologie, Munster, Germany
    Neuropharmacology 39:202-10. 2000
    ..1 channel, 98 micromol/l for the Kv1.2 channel, 12 micromol/l for the Kv1.3 channel, 226 micromol/l for the Kv2.1 channel, 6 micromol/l for the Kv3.1 channel and 11 micromol/l for the Kv3.2 channel...
  43. pmc Glycosylation affects rat Kv1.1 potassium channel gating by a combined surface potential and cooperative subunit interaction mechanism
    Itaru Watanabe
    Department of Biological Sciences, Fordham University, Bronx, NY 10458, USA
    J Physiol 550:51-66. 2003
    ..Differences in glycosylation pattern among closely related channels may contribute to their functional differences and affect their physiological roles...
  44. ncbi A novel beta subunit increases rate of inactivation of specific voltage-gated potassium channel alpha subunits
    M J Morales
    Department of Pharmacology, Duke University Medical Center, Durham, North Carolina 27710
    J Biol Chem 270:6272-7. 1995
    ..This study shows that voltage-gated K+ channel beta subunits are present outside the central nervous system, and that at least one member of this family selectively modulates inactivation of K+ channel alpha subunits...
  45. ncbi Both N- and C-terminal regions contribute to the assembly and functional expression of homo- and heteromultimeric voltage-gated K+ channels
    W F Hopkins
    Geriatric Research Education and Clinical Center, Veterans Affairs Medical Center, Seattle, Washington 98108
    J Neurosci 14:1385-93. 1994
    ..1 (MBK1), a mouse Shaker-like K+ channel...
  46. ncbi The D-diastereomer of ShK toxin selectively blocks voltage-gated K+ channels and inhibits T lymphocyte proliferation
    Christine Beeton
    Department of Physiology and Biophysics, University of California, California, Irvine, 92697 4560, USA
    J Biol Chem 283:988-97. 2008
    ..Being resistant to proteolysis and nonantigenic, this analogue should be useful in K(+) channel studies; all-d analogues with improved Kv1.3 potency and specificity may have therapeutic advantages...
  47. ncbi The investigation of interactions of kappa-Hefutoxin1 with the voltage-gated potassium channels: a computational simulation
    M Zarrabi
    Department of Biophysics, Faculty of Science, Tarbiat Modares University, Tehran, Iran
    Proteins 71:1441-9. 2008
    ....
  48. ncbi Lack of potassium channel induces proliferation and survival causing increased neurogenesis and two-fold hippocampus enlargement
    Malin Almgren
    Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden
    Hippocampus 17:292-304. 2007
    ..This phenotype is a result, at least in DG, from increased proliferation, neurogenesis, and enhanced general hippocampal cell survival...
  49. pmc Arrangement of Kv1 alpha subunits dictates sensitivity to tetraethylammonium
    Ahmed Al-Sabi
    International Centre for Neurotherapeutics, Dublin City University, Dublin 9, Ireland
    J Gen Physiol 136:273-82. 2010
    ..These collective findings indicate that assembly of alpha subunits can be directed by this optimized concatenation, and that subunit arrangement in heteromeric Kv channels affects TEA affinity...
  50. ncbi Amino-terminal determinants of U-type inactivation of voltage-gated K+ channels
    Harley T Kurata
    Department of Physiology, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada
    J Biol Chem 277:29045-53. 2002
    ..1. These data suggest that intersubunit T1 domain interactions influence U-type inactivation in Kv1 channels, and suggest a generalized influence of the T1 domain on U-type inactivation between Kv channel subfamilies...
  51. doi Respiratory syncytial virus, human bocavirus and rhinovirus bronchiolitis in infants
    F Midulla
    Department of Pediatrics, Sapienza University of Rome, Viale Regina Elena 324, 00165 Rome, Italy
    Arch Dis Child 95:35-41. 2010
    ..To investigate the prevalence of 14 viruses in infants with bronchiolitis and to study demographic and clinical differences in those with respiratory syncytial virus (RSV), human bocavirus (hBoV) and rhinovirus (RV) infection...
  52. doi Lipophilic and stereospecific interactions of amino-amide local anesthetics with human Kv1.1 channels
    Mark A Punke
    Department of Anesthesiology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Anesthesiology 109:895-904. 2008
    ..1. The use of stereoisomers allowed testing of the role of polar drug actions...
  53. ncbi Differences in androgen-dependent induction of mk1, true tissue kallikrein in C3H/HeN and ICR mouse submandibular gland
    K Kurihara
    Department of Oral Physiology, Meikai University School of Dentistry, Sakado, Saitama, Japan
    Horm Metab Res 31:370-4. 1999
    Androgen-dependent induction of mk1, true tissue kallikrein, in submandibular gland was studied in C3H/HeN and ICR mice and their F1 progeny...
  54. ncbi The distribution of ganglioside-like moieties in peripheral nerves
    K A Sheikh
    Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Brain 122:449-60. 1999
    ..1 and Kv1.5 and are thus not likely carried by these ion channels. In contrast with Gal(beta1-3)GalNAc, GT1b-like moieties are restricted to the axolemma...
  55. ncbi Tissue kallikrein mK13 is a candidate processing enzyme for the precursor of interleukin-1beta in the submandibular gland of mice
    Chenjuan Yao
    Department of Molecular Oral Physiology, Institute of Health Biosciences, The University of Tokushima Graduate School, 3 18 15, Kuramoto Cho, Tokushima shi, Tokushima 770 8504, Japan
    J Biol Chem 281:7968-76. 2006
    ..On the other hand, mK1, mK9, mK13, and mK22, members of the kallikrein family, were detected strongly in the SMG but not in other tissues...
  56. ncbi Estrogen-dependent expression of the tissue kallikrein gene (Klk1) in the mouse uterus and its implications for endometrial tissue growth
    Sanath Rajapakse
    Division of Biological Sciences, Graduate School of Science, Hokkaido University, Sapporo, Japan
    Mol Reprod Dev 74:1053-63. 2007
    Tissue kallikrein mK1 is a serine protease involved in the generation of bioactive kinins for normal cardiac and arterial function in the mouse...
  57. doi Identification of amino acids in the pore region of Kv1.2 potassium channel that regulate its glycosylation and cell surface expression
    Iku Utsunomiya
    Department of Pharmacotherapeutics, Showa Pharmaceutical University, Tokyo, Japan
    J Neurochem 112:913-23. 2010
    ..2 is regulated by specific amino acids in the pore region in a similar manner to Kv1.1 and Kv1.4, and that the cell surface expression of Kv1.2, a channel intermediate between Kv1.1 and Kv1.4, can be attributed to these specific residues...
  58. ncbi Deranged Kv channel regulation in fibroblasts from mice lacking the serum and glucocorticoid inducible kinase SGK1
    Ekaterina Shumilina
    Department of Physiology, University of Tuebingen, Germany
    J Cell Physiol 204:87-98. 2005
    ..In conclusion, lack of SGK1 does not abrogate Kv channel activity but abolishes regulation of those channels by serum, glucocorticoids and IGF-1, an effect influencing capacitative Ca(2+) entry...
  59. ncbi A family of three mouse potassium channel genes with intronless coding regions
    K G Chandy
    Department of Medicine, University of California, Irvine 92717
    Science 247:973-5. 1990
    ..channels in mammalian cells, mouse genomic clones have been isolated with a potassium channel complementary DNA, MBK1, that is homologous to the Drosophila potassium channel gene, Shaker...
  60. ncbi Neuromyotonia and limbic encephalitis sera target mature Shaker-type K+ channels: subunit specificity correlates with clinical manifestations
    Kleopas A Kleopa
    Department of Clinical Neurosciences, Cyprus Institute of Neurology and Genetics, Nicosia, Cyprus, PA, USA
    Brain 129:1570-84. 2006
    ..Although more than one type of antibody is often detectable in individual sera, higher affinity for certain subunits or subunit combinations may determine the range of clinical manifestations...
  61. ncbi Fast apoptosis and erythroid differentiation induced by imatinib mesylate in JURL-MK1 cells
    Katerina Kuzelova
    Institute of Hematology and Blood Transfusion, U Nemocnice 1, 128 20 Prague 2, Czech Republic
    J Cell Biochem 95:268-80. 2005
    We compare the effects of Imatinib mesylate (Glivec) on chronic myeloid leukemia derived cell lines K562 and JURL-MK1. In both cell lines, the cell cycle arrests in G(1)/G(0) phase within 24 h after the addition of 1 microM Imatinib...
  62. doi Real time detection of anthrax spores using highly specific anti-EA1 recombinant antibodies produced by competitive panning
    Tracey E Love
    Detection Department, Dstl Porton Down, Salisbury, Wiltshire, SP4 OJQ, United Kingdom
    J Immunol Methods 334:1-10. 2008
    ..The aim was to produce single chain antibodies (scFvs) to EA1, a Bacillus anthracis S-layer protein that is also present, although not identical, in related to Bacillus species...
  63. ncbi Kv1.1 and Kv1.3 channels contribute to the delayed-rectifying K+ conductance in rat choroid plexus epithelial cells
    Tracey Speake
    School of Biological Sciences, University of Manchester, Manchester M13 9PT, United Kingdom
    Am J Physiol Cell Physiol 286:C611-20. 2004
    ..In conclusion, Kv1.1 and Kv1.3 channels make a significant contribution to K+ efflux at the apical membrane of the choroid plexus...
  64. doi Kv1.1 and Kv1.3 channels contribute to the degeneration of retinal ganglion cells after optic nerve transection in vivo
    P D Koeberle
    Division of Anatomy, Department of Surgery, University of Toronto, Ontario, Canada
    Cell Death Differ 17:134-44. 2010
    ..Kv1.1 depletion increased the antiapoptotic gene, Bcl-X(L), whereas Kv1.3 depletion reduced the proapoptotic genes, caspase-3, caspase-9 and Bad...
  65. doi Immuno capture PCR for rapid and sensitive identification of pathogenic Bacillus anthracis
    Shivakiran S Makam
    Microbiology Division, Defence Food Research Laboratory, Siddartha Nagar, Mysore, 570011, Karnataka, India
    World J Microbiol Biotechnol 29:2379-88. 2013
    ..Rapid and accurate detection of Bacillus anthracis was achieved using anti-EA1 antibodies to capture the cells and two primer sets targeting the virulence factors of the pathogen i.e...
  66. ncbi A variable residue in the pore of Kv1 channels is critical for the high affinity of blockers from sea anemones and scorpions
    Bernard Gilquin
    Departement d Ingenierie et d Etudes des Proteines, Commissariat à l Energie Atomique Saclay, 91191 Gif sur Yvette Cedex, France
    J Biol Chem 280:27093-102. 2005
    ..Altogether, our data suggest that the residue at position 379 of Kv1 channels controls the affinity of a number of blocking toxins...
  67. ncbi Altered expression of potassium channel subunit mRNA and alpha-dendrotoxin sensitivity of potassium currents in rat dorsal root ganglion neurons after axotomy
    E K Yang
    Department of Physiology, Kyungpook National University, Daegu 700 422, South Korea
    Neuroscience 123:867-74. 2004
    ....
  68. pmc Low-threshold potassium currents stabilize IID-sensitivity in the inferior colliculus
    Anita Karcz
    Carl Ludwig Institute for Physiology, University of Leipzig, Medical School Leipzig, Germany
    Front Neural Circuits 6:60. 2012
    ..1...
  69. ncbi Temporal and spatial patterns of Kv1.1 and Kv1.2 protein and gene expression in spinal cord white matter after acute and chronic spinal cord injury in rats: implications for axonal pathophysiology after neurotrauma
    Soheila Karimi-Abdolrezaee
    Division of Neurosurgery, Toronto Western Research Institute, Krembil Neuroscience Center, University of Toronto, Toronto, Ontario, Canada M5T 2S8
    Eur J Neurosci 19:577-89. 2004
    ..In contrast, the redistribution of the axonal K+ channel subunits occurs very early postinjury and probably reflects a disruption of the juxtaparanodal axonal region due to physical trauma, as shown by altered localization of Caspr...
  70. doi Episodic ataxia type 1 without episodic ataxia: the diagnostic utility of nerve excitability studies in individuals with KCNA1 mutations
    S Veronica Tan
    Department of Neurology and Neurophysiology, St Thomas Hospital, Guy s and St Thomas NHS Foundation Trust, King s Health Partners Academic Health Science Centre, London, UK Institute of Neurology, University College London, Queen Square, London, UK
    Dev Med Child Neurol 55:959-62. 2013
    Episodic ataxia type 1 (EA1) is caused by mutations in the KCNA1 gene encoding the fast potassium channel Kv1.1 and is characterized clinically by brief episodes of ataxia and continuous and spontaneous motor unit activity...
  71. ncbi Developmental and androgenic regulation of the immunocytochemical distribution of mK1, a true tissue kallikrein, in the granular convoluted tubule of the mouse submandibular gland
    Shingo Kurabuchi
    Department of Cell Biology and Anatomical Sciences, The City University of New York Medical School, New York 10031, USA
    J Histochem Cytochem 50:135-45. 2002
    The action of androgens on the immunocytochemical distribution of mK1, a true tissue kallikrein, was examined in the submandibular gland (SMG) of developing and adult mice by indirect enzyme-labeled and immunogold-labeled antibody ..
  72. ncbi Purification, characterization and biosynthesis of parabutoxin 3, a component of Parabuthus transvaalicus venom
    Isabelle Huys
    Laboratory of Toxicology, University of Leuven, Leuven, Belgium
    Eur J Biochem 269:1854-65. 2002
    ..The scaffold of PBTx3 is homologous to most other alpha-KTx scorpion toxins...
  73. ncbi Two heteromeric Kv1 potassium channels differentially regulate action potential firing
    Paul D Dodson
    Department of Cell Physiology and Pharmacology, University of Leicester, Leicester, LE1 9HN, United Kingdom
    J Neurosci 22:6953-61. 2002
    ..Our results show that heteromeric channels containing Kv1.2 subunits govern AP firing and suggest that their localization at the initial segment of MNTB axons can explain their dominance of AP firing behavior...
  74. ncbi Developmental switch of S-layer protein synthesis in Bacillus anthracis
    Tâm Mignot
    Toxines et Pathogénie Bactériennes URA 2172, CNRS, Paris, France
    Mol Microbiol 43:1615-27. 2002
    ..Bacillus anthracis has two S-layer genes, sap and eag, encoding the S-layer proteins Sap and EA1 respectively...
  75. ncbi Heteromultimeric potassium channels formed by members of the Kv2 subfamily
    J T Blaine
    Department of Physiology and Biophysics, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    J Neurosci 18:9585-93. 1998
    ..1 and Kv2.2 subunits are capable of heteromultimerization. Thus, in native cells either Kv2.1 and Kv2.2 subunits are targeted at an early stage to different biosynthetic compartments or heteromultimerization otherwise is inhibited...
  76. pmc Identification of selective inhibitors of the potassium channel Kv1.1-1.2((3)) by high-throughput virtual screening and automated patch clamp
    Sören J Wacker
    Max Planck Institute for Biophysical Chemistry, Computational Biomolecular Dynamics Group, Am Fassberg 11, 37077 Gottingen, Germany
    ChemMedChem 7:1775-83. 2012
    ....
  77. pmc Structural basis of the selective block of Kv1.2 by maurotoxin from computer simulations
    Rong Chen
    Research School of Biology, Australian National University, Canberra, Australian Capital Territory, Australia
    PLoS ONE 7:e47253. 2012
    ..Potential of mean force calculations show that MTx blocks Kv1.1, Kv1.2 and Kv1.3 with an IC(50) value of 6 µM, 0.6 nM and 18 µM, respectively...
  78. pmc KCNE4 is an inhibitory subunit to Kv1.1 and Kv1.3 potassium channels
    Morten Grunnet
    Department of Medical Physiology, The Panum Institute, University of Copenhagen, DK 2200 Copenhagen N, Denmark
    Biophys J 85:1525-37. 2003
    ..Having the broad distribution of Kv1 channels in mind, the demonstrated inhibitory property of KCNE4-subunits could locally and/or transiently have a dramatic influence on cellular excitability and on setting resting membrane potentials...
  79. pmc Functional analysis of the Kv1.1 N255D mutation associated with autosomal dominant hypomagnesemia
    Jenny van der Wijst
    Department of Physiology, Radboud University Nijmegen Medical Centre, 6500 HB Nijmegen, The Netherlands
    J Biol Chem 285:171-8. 2010
    ..Taken together, our data showed that an asparagine at position 255 in Kv1.1 is required for normal voltage dependence and kinetics of channel gating...
  80. doi Experimental validation of in silico predicted KCNA1, KCNA2, KCNA6 and KCNQ2 genes for association studies of peripheral nerve hyperexcitability syndrome in Jack Russell Terriers
    Mario Van Poucke
    Department of Nutrition, Genetics, and Ethology, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium
    Neuromuscul Disord 22:558-65. 2012
    ..However, the four missense sequence variations and the 14 transcript variants of KCNQ2 will contribute to the study of the functional diversity of voltage-gated potassium channels...
  81. doi A new Kaliotoxin selective towards Kv1.3 and Kv1.2 but not Kv1.1 channels expressed in oocytes
    Najwa Abbas
    CNRS UMR 6231, CRN2M, Université de la Méditerranée et Université Paul Cézanne, 51, Bd Pierre Dramard, 13916 Marseilles, France
    Biochem Biophys Res Commun 376:525-30. 2008
    ..2 was expected (EC(50) values, 1.1+/-0.02 and 10.4+/-1.5 nM, respectively) but its total inefficacy on Kv1.1 was very surprising. 3D molecular modeling of Aam-KTX brought putative answers to this difference in selectivity...
  82. doi Clinical spectrum of voltage-gated potassium channel autoimmunity
    K M Tan
    Department of Neurology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Neurology 70:1883-90. 2008
    ..To document neurologic, oncologic, and serologic associations of patients in whom voltage-gated potassium channel (VGKC) autoantibodies were detected in the course of serologic evaluation for neuronal, glial, and muscle autoantibodies...
  83. pmc K+ channels at the axon initial segment dampen near-threshold excitability of neocortical fast-spiking GABAergic interneurons
    Ethan M Goldberg
    Smilow Neuroscience Program, New York University School of Medicine, Smilow Research Building, Sixth Floor, 522 First Avenue, New York, NY 10016, USA
    Neuron 58:387-400. 2008
    ..Thus, Kv1 channels provide a key counterbalance to the established rapid-response characteristics of FS cells, regulating excitability through a unique combination of electrophysiological properties and discrete subcellular localization...
  84. doi Different residues in channel turret determining the selectivity of ADWX-1 inhibitor peptide between Kv1.1 and Kv1.3 channels
    Shi Jin Yin
    State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan 430072, PR China
    J Proteome Res 7:4890-7. 2008
    ..3 over Kv1.1. Mutation of Kv1.1 turret residues to match the sequence of Kv1.3 lead to increased inhibition of Kv1.1 activity. These studies may lead to improvements in peptide inhibitor drug development...
  85. doi A novel KCNA1 mutation associated with global delay and persistent cerebellar dysfunction
    Michelle K Demos
    Department of Pediatric Neurology, British Columbia s Children s Hospital, Vancouver, British Columbia, Canada
    Mov Disord 24:778-82. 2009
    ..Together, our data suggests that KCNA1 mutations are associated with a broader clinical phenotype, which may include persistent cerebellar dysfunction and cognitive delay...
  86. ncbi Episodic ataxia type 1 and 2 (familial periodic ataxia/vertigo)
    T Brandt
    Department of Neurology, Ludwig Maximilians Universitat Munchen, Germany
    Audiol Neurootol 2:373-83. 1997
    ..As effective as acetazolamide is in preventing attacks, prospective studies still have to prove whether it can prevent progressive ataxia in EA-2 or even improve chronic cerebellar deficits...
  87. pmc Voltage-gated potassium channel (Kv) subunits expressed in the rat cochlear nucleus
    Zoltán Rusznák
    Department of Physiology, Medical and Health Science Centre, University of Debrecen, PO Box 22, H 4012 Debrecen, Hungary
    J Histochem Cytochem 56:443-65. 2008
    ..Our data provide new information about the Kv expression of the CN and also suggest potential functional heterogeneity of the giant and pyramidal cells...
  88. ncbi Developmental seizure susceptibility of kv1.1 potassium channel knockout mice
    J M Rho
    Department of Neurology and Pediatrics, Geriatric Research, Education and Clinical Center, Puget Sound Health Care System, University of Washington, Seattle, WA, USA
    Dev Neurosci 21:320-7. 1999
    ..The Kv1. 1 knockout mouse possesses many features desirable in a developmental animal epilepsy model and represents a clinically relevant model of early-onset epilepsies...
  89. pmc Functional coupling between the Kv1.1 channel and aldoketoreductase Kvbeta1
    Yaping Pan
    Department of Physiology and Cellular Biophysics, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    J Biol Chem 283:8634-42. 2008
    ..Thus, cofactor oxidation by Kvbeta1 is regulated by membrane potential, presumably via voltage-dependent structural changes in Kv1.1 channels...
  90. pmc Long QT and ventricular arrhythmias in transgenic mice expressing the N terminus and first transmembrane segment of a voltage-gated potassium channel
    B London
    Division of Cardiology, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    Proc Natl Acad Sci U S A 95:2926-31. 1998
    ..These changes correlate with a marked decrease in the level of Kv1.5 polypeptide. Thus, overexpression of a truncated K+ channel in the heart alters native K+ channel expression and has profound effects on cardiac excitability...
  91. ncbi Hyperalgesia in mice lacking the Kv1.1 potassium channel gene
    J D Clark
    Department of Anesthesiology and Otolaryngology, The Virginia Merrill Bloedel Hearing Research Center, Seattle, WA 98195 7923, USA
    Neurosci Lett 251:121-4. 1998
    ..Morphine induced antinociception in Kv1.1 null mutant animals was blunted. These studies indicate that Kv1.1 plays an important role in nociceptive and antinociceptive signaling pathways...
  92. ncbi Temperature-sensitive neuromuscular transmission in Kv1.1 null mice: role of potassium channels under the myelin sheath in young nerves
    L Zhou
    Department of Physiology, University of Wisconsin School of Medicine, Madison, Wisconsin 53706, USA
    J Neurosci 18:7200-15. 1998
    ..This paper demonstrates that under certain situations of physiological stress, the functional role of myelin-covered K channels is dramatically enhanced as the transition zone at the neuromuscular junction is approached...
  93. ncbi Manipulation of the potassium channel Kv1.1 and its effect on neuronal excitability in rat sensory neurons
    Xian Xuan Chi
    Department of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    J Neurophysiol 98:2683-92. 2007
    ..These results demonstrate that Kv1.1 plays an important role in limiting AP firing and that siRNA may be a useful approach to establish the role of specific ion channels in the absence of selective antagonists...
  94. pmc A missense mutation in the Kv1.1 voltage-gated potassium channel-encoding gene KCNA1 is linked to human autosomal dominant hypomagnesemia
    Bob Glaudemans
    Department of Physiology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    J Clin Invest 119:936-42. 2009
    ..1 channel function. These data suggest that Kv1.1 is a renal K+ channel that establishes a favorable luminal membrane potential in DCT cells to control TRPM6-mediated Mg2+ reabsorption...
  95. ncbi Expression and function of voltage-dependent potassium channel genes in human airway smooth muscle
    S Adda
    Department of Animal Biology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6046, USA
    J Biol Chem 271:13239-43. 1996
    ..9 mM). Human airway myocytes express mRNA from several members of the Kv1 gene family; the channel that underlies the predominate voltage-dependent current and the regulation of basal tone appears to be Kv1.5...
  96. ncbi In situ hybridization reveals extensive diversity of K+ channel mRNA in isolated ferret cardiac myocytes
    M V Brahmajothi
    Department of Pharmacology, Duke University Medical Center, Durham, NC 27710, USA
    Circ Res 78:1083-9. 1996
    ....
  97. ncbi Expression of a genomic clone encoding a brain potassium channel in mammalian cells using lipofection
    S Ferroni
    Department of Biology, University of California San Diego, La Jolla 92093 0319
    Eur Biophys J 21:185-91. 1992
    A genomic clone encoding a mouse brain K+ channel (MBK1) was isolated, characterized and expressed in COS cells using the lipofection technique...
  98. doi Episodic ataxias 1 and 2
    Robert W Baloh
    Department of Neurology, University of California, Los Angeles, CA 90095 1769, USA
    Handb Clin Neurol 103:595-602. 2012
    ..Episodic ataxia type 1 (EA1) is characterized by brief episodes of ataxia, typically lasting seconds, and interictal myokymia, while episodic ..
  99. doi ImKTx1, a new Kv1.3 channel blocker with a unique primary structure
    Zongyun Chen
    State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan 430072, People s Republic of China
    J Biochem Mol Toxicol 25:244-51. 2011
    ..3 channel blocker with a unique primary structure. Our results indicate the diversity of K(+) channel toxins from scorpion venoms and also provide a new molecular template targeting Kv1.3 channel...
  100. doi Episodic ataxia type 1 mutations affect fast inactivation of K+ channels by a reduction in either subunit surface expression or affinity for inactivation domain
    Paola Imbrici
    Section of Human Physiology, Dept of Internal Medicine, University of Perugia School of Medicine, Via del Giochetto, Perugia, Italy
    Am J Physiol Cell Physiol 300:C1314-22. 2011
    Episodic ataxia type 1 (EA1) is an autosomal dominant disorder characterized by continuous myokymia and episodic attacks of ataxia. Mutations in the gene KCNA1 that encodes the voltage-gated potassium channel Kv1...
  101. doi Changes in cell adhesivity and cytoskeleton-related proteins during imatinib-induced apoptosis of leukemic JURL-MK1 cells
    K Kuzelova
    Department of Cellular Biochemistry, Institute of Hematology and Blood Transfusion, Prague, Czech Republic
    J Cell Biochem 111:1413-25. 2010
    ..of imatinib mesylate, an inhibitor of Bcr-Abl protein used in front-line CML therapy, on the adhesivity of JURL-MK1 cells to fibronectin and searched for underlying changes in the cell proteome...

Research Grants68

  1. Structures of Eukaryotic K Channels and Mistic Action
    Senyon Choe; Fiscal Year: 2007
    ..We will learn a great deal about structural mechanisms underlying voltage activation and inactivation of eukaryotic Kv channels. ..
  2. Targeting of Voltage-gated K+ Channels to Lipid Rafts
    Michael Tamkun; Fiscal Year: 2004
    ..1-containing lipid rafts from brain. This proposed research examines a new area in Kv channel research that will have important implications in multiple tissue systems. ..
  3. A Mouse Model of Mammalian Shaker Channel RNA Editing
    Tarun Bhalla; Fiscal Year: 2006
    ..Episodic Ataxia / Myokymia Syndrome Type 1 (EA1) is the only human ataxia known to be caused by dysfunction of a K+ channel...
  4. MOLECULAR AND CELLULAR PHYSIOLOGY OF EPISODIC ATAXIA
    James Maylie; Fiscal Year: 2001
    DESCRIPTION: Episodic ataxia type 1 (EA1) is an autosomal dominant human disorder which produces attacks of generalized ataxia as well as cognitive dysfunction...
  5. REGULATORY MECHANISMS OF CARDIAC REPOLARIZATION
    Michael Tamkun; Fiscal Year: 2005
    ..Given the role that both Kv channels and connexins play in cardiac and vascular smooth muscle, the proposed research will significantly advance our understanding of electrical excitability in the cardiovascular system. ..
  6. MOLECULAR AND CELLULAR PHYSIOLOGY OF EPISODIC ATAXIA
    James Maylie; Fiscal Year: 2006
    Episodic Ataxia / Myokymia Syndrome Type 1 (EA1) is an inherited autosomal dominant human neurological disorder...
  7. MOLECULAR AND CELLULAR PHYSIOLOGY OF EPISODIC ATAXIA
    James Maylie; Fiscal Year: 2003
    Episodic Ataxia / Myokymia Syndrome Type 1 (EA1) is an inherited autosomal dominant human neurological disorder...
  8. Role of LGI1 in Autosomal Dominant Lateral Temporal Lobe Epilepsy
    Matthew P Anderson; Fiscal Year: 2010
    ..The results should provide new insights into the cellular and molecular basis of human epilepsy, and help identify new potential therapeutic targets to treat this common brain disorder. ..
  9. Role of LGI1 in Autosomal Dominant Lateral Temporal Lobe Epilepsy
    Matthew Anderson; Fiscal Year: 2009
    ..The results should provide new insights into the cellular and molecular basis of human epilepsy, and help identify new potential therapeutic targets to treat this common brain disorder. ..
  10. MECHANISMS OF REPOLARIZATION-INDUCED ARRHYTHMIAS
    Guy Salama; Fiscal Year: 2002
    ..abstract_text> ..
  11. Nervous System Channelopathies: Pathogenesis & Treatment
    ROBERT GRIGGS; Fiscal Year: 2007
    ..there is no established treatment and there have been no well-designed clinical trials; (3) the episodic ataxias EA1 and EA2 for which treatment is not yet defined...
  12. Genetics of Familial Episodic Ataxia
    Joanna C Jen; Fiscal Year: 2010
    Familial episodic ataxia (EA) syndromes are rare and heterogeneous (EA1-EA7 to date) monogenic disorders, the study of which has illuminated previously unrecognized but important roles of ion channels and transporters in neuronal and ..
  13. Gene therapy against conditioned fear
    Robert Sapolsky; Fiscal Year: 2005
    ....
  14. AUDITORY SIGNALING, THE FUNCTIONAL ROLE OF KV CHANNELS
    BRUCE TEMPEL; Fiscal Year: 2003
    ..The proposed studies and models based on the Kvl.1 knockout mouse mutants should also be informative regarding the neuronal dysfunction that underlies this human disease. ..
  15. SYNAPTIC TRANSMISSION DURING NEURONAL DIFFERENTIATION
    KENNA PEUSNER; Fiscal Year: 2007
    ..abstract_text> ..
  16. ROLE OF PLEIOTROPHIN IN BREAST CANCER
    THOMAS DEUEL; Fiscal Year: 2004
    ..Both MK and MK1-3, 59-121 promote more aggressive tumor growth and perhaps tumor angiogenesis (in progress) when they are ..