KRT23

Summary

Gene Symbol: KRT23
Description: keratin 23
Alias: CK23, HAIK1, K23, keratin, type I cytoskeletal 23, CK-23, cytokeratin 23, histone deacetylase inducible keratin 23, hyperacetylation-inducible type I keratin, keratin 23 (histone deacetylase inducible), keratin 23, type I, type I intermediate filament cytokeratin
Species: human
Products:     KRT23

Top Publications

  1. Hesse M, Magin T, Weber K. Genes for intermediate filament proteins and the draft sequence of the human genome: novel keratin genes and a surprisingly high number of pseudogenes related to keratin genes 8 and 18. J Cell Sci. 2001;114:2569-75 pubmed
    ..We describe the limits of our analysis and discuss the striking unevenness of pseudogene derivation in the IF multigene family. Finally, we propose to extend the nomenclature of Moll and colleagues to any novel keratin. ..
  2. Tolstonog G, Sabasch M, Traub P. Cytoplasmic intermediate filaments are stably associated with nuclear matrices and potentially modulate their DNA-binding function. DNA Cell Biol. 2002;21:213-39 pubmed
  3. Zhang J, Wang L, Huang H, Nelson M, Smith D. Keratin 23 (K23), a novel acidic keratin, is highly induced by histone deacetylase inhibitors during differentiation of pancreatic cancer cells. Genes Chromosomes Cancer. 2001;30:123-35 pubmed
    ..The gene is named K23 (for human type I Keratin 23, KRT23). K23 mRNA was highly induced by NaBu in different pancreatic cancer cells...
  4. Birkenkamp Demtroder K, Mansilla F, Sørensen F, Kruhøffer M, Cabezon T, Christensen L, et al. Phosphoprotein Keratin 23 accumulates in MSS but not MSI colon cancers in vivo and impacts viability and proliferation in vitro. Mol Oncol. 2007;1:181-95 pubmed publisher
    ..Keratin23 expression correlated significantly with transcription factor CEBPB. In conclusion, Keratin23 expression is a novel and important difference between microsatellite-stable and microsatellite-instable colon cancers. ..
  5. Liffers S, Maghnouj A, Munding J, Jackstadt R, Herbrand U, Schulenborg T, et al. Keratin 23, a novel DPC4/Smad4 target gene which binds 14-3-3?. BMC Cancer. 2011;11:137 pubmed publisher
    ..8 and 18, heat shock proteins 60 and 70, plectin 1, as well as 14-3-3? and ? as novel proteins present in the KRT23-interacting complex...
  6. Wang P, Correia K, Ho H, Venayak N, Nemr K, Flick R, et al. An interspecies malate-pyruvate shuttle reconciles redox imbalance in an anaerobic microbial community. ISME J. 2019;13:1042-1055 pubmed publisher
    ..restrictus strain PER-K23 cultures were performed to validate the model predictions. The model resolved that the amino acid dependency of D...
  7. Tsushima K, Tsuge M, Hiraga N, Uchida T, Murakami E, Makokha G, et al. Comparison of intracellular responses between HBV genotype A and C infection in human hepatocyte chimeric mice. J Gastroenterol. 2019;: pubmed publisher
    ..In HBV genotype A-infected hepatocytes, 172 genes, including KRT23 and C10orf54, were significantly more highly expressed than in HBV genotype C-infected cells, whereas 10 genes, ..
  8. Brix D, Tvingsholm S, Hansen M, Clemmensen K, Ohman T, Siino V, et al. Release of transcriptional repression via ErbB2-induced, SUMO-directed phosphorylation of myeloid zinc finger-1 serine 27 activates lysosome redistribution and invasion. Oncogene. 2019;38:3170-3184 pubmed publisher
    ..The phosphorylation of MZF1-S27 is preceded by poly-SUMOylation of K23, which can make S27 accessible to efficient phosphorylation by PAK4...
  9. Zhao P, Kavarthapu R, Anbazhagan R, Liao M, Dufau M. Interaction of positive coactivator 4 with histone 3.3 protein is essential for transcriptional activation of the luteinizing hormone receptor gene. Biochim Biophys Acta Gene Regul Mech. 2018;1861:971-981 pubmed publisher
    ..3 acetylated at K9, K14, K18, K23 and K27 as a PC4 interacting protein. The association of PC4 with H3.3 was corroborated by IP and re-ChIP using H3...

More Information

Publications47

  1. Ebbensgaard A, Mordhorst H, Overgaard M, Aarestrup F, Hansen E. Dissection of the antimicrobial and hemolytic activity of Cap18: Generation of Cap18 derivatives with enhanced specificity. PLoS ONE. 2018;13:e0197742 pubmed publisher
    ..29 to be essential for the inherent low hemolytic activity of Cap18 and that substitution of the residues K16, K23, or G21 by any hydrophobic residues enhances the hemolytic activity...
  2. Martinez Abad A, Pinero D, Chorro E, Bataille L, Alio J. Development of a Reference Model for Keratoconus Progression Prediction Based on Characterization of the Course of Nonsurgically Treated Cases. Cornea. 2018;37:1497-1505 pubmed publisher
    ..39 ± 51.09% and a median of 1.85%. This parameter was significantly related to the baseline sphere, K23 mm (steepest central keratometry), and Q80 mm (P < 0.001, R = 0.429)...
  3. Yao Z, Guo Z, Wang Y, Li W, Fu Y, Lin Y, et al. Integrated Succinylome and Metabolome Profiling Reveals Crucial Role of S-Ribosylhomocysteine Lyase in Quorum Sensing and Metabolism of Aeromonas hydrophila. Mol Cell Proteomics. 2019;18:200-215 pubmed publisher
    ..mutagenesis, we observed that the succinylation of lysines on S-ribosylhomocysteine lyase (LuxS) at the K23 and K30 sites positively regulate the production of the quorum sensing autoinducer AI-2, and that these PTMs ..
  4. Abdelkrim S, Jebara S, Jebara M. Antioxidant systems responses and the compatible solutes as contributing factors to lead accumulation and tolerance in Lathyrus sativus inoculated by plant growth promoting rhizobacteria. Ecotoxicol Environ Saf. 2018;166:427-436 pubmed publisher
    ..leguminosarum (M5) + B. simplex + Luteibacter sp + Variovorax sp) and I5 (R. leguminosarum (M5) + P. fluorescens (K23) + Luteibacter sp + Variovorax sp) in plant mechanisms responses. Pb application induced its immediate uptake by L...
  5. Kang S, Chatterjee S, Alam S, Salzberg A, Milici J, van der Burg S, et al. Effect of Productive Human Papillomavirus 16 Infection on Global Gene Expression in Cervical Epithelium. J Virol. 2018;92: pubmed publisher
    ..protein association network of immune response genes, and top downregulated genes RPTN, SERPINB4, KRT23, and KLK8 In particular, KLK8 and SERPINB4 were shown to be upregulated in cancer, which ..
  6. Sam S, Scoccia B, Yalamanchi S, Mazzone T. Metabolic dysfunction in obese Hispanic women with polycystic ovary syndrome. Hum Reprod. 2015;30:1358-64 pubmed publisher
    ..This project was supported by the following National Institutes of Health grants: K23 DK080988-01A1 to S.S. and UL1RR029879 to CTSA at University of Illinois...
  7. Kibbe M, Dardik A, Velazquez O, Conte M. The vascular surgeon-scientist: a 15-year report of the Society for Vascular Surgery Foundation/National Heart, Lung, and Blood Institute-mentored Career Development Award Program. J Vasc Surg. 2015;61:1050-7 pubmed publisher
    ..career development program that provides a financial supplement to surgeon-scientists receiving NIH K08 or K23 career development awards...
  8. Weissbach F, Hirsch H. Comparison of Two Commercial Tick-Borne Encephalitis Virus IgG Enzyme-Linked Immunosorbent Assays. Clin Vaccine Immunol. 2015;22:754-60 pubmed publisher
    ..Both assays use whole TBEV antigens, but they differ in viral strains (Neudoerfl for ELISA-1 and K23 for ELISA-2) and cutoff values...
  9. Schmid D, Zeis T, Sobrio M, Schaeren Wiemers N. MAL overexpression leads to disturbed expression of genes that influence cytoskeletal organization and differentiation of Schwann cells. ASN Neuro. 2014;6: pubmed publisher
    ..A number of those, including S100a4, RhoU and Krt23, are implicated in cytoskeletal organization and plasma membrane dynamics...
  10. Rothrock R, Steinberger J, Badgery H, Hecht A, Cho S, Caridi J, et al. Frailty status as a predictor of 3-month cognitive and functional recovery following spinal surgery: a prospective pilot study. Spine J. 2019;19:104-112 pubmed publisher
    ..Frailty screening can help preoperatively identify patients who may experience protracted cognitive and functional recovery. ..
  11. Ge Y, Zhu J, Wang X, Zheng N, Tu C, Qu J, et al. Mapping dynamic histone modification patterns during arsenic-induced malignant transformation of human bladder cells. Toxicol Appl Pharmacol. 2018;355:164-173 pubmed publisher
    ..MMAIII exposure caused a time-dependent increase in histone H3 acetylation on lysine K4, K9, K14, K18, K23, and K27, but a decrease in acetylation on lysine K5, K8, K12, and K16 of histone H4...
  12. Oarada M, Takahashi Nakaguchi A, Abe T, Nikawa T, Miki T, Gonoi T. Refeeding with glucose rather than fructose elicits greater hepatic inflammatory gene expression in mice. Nutrition. 2015;31:757-65 pubmed publisher
    ..Gadd45 a, Perk, Inhbe), detoxification genes (Hmox1, Gsta1, Abca8b), genes involved in tissue regeneration (Gdf15, Krt23, Myc, Tnfrsf12a, Mthfd2), and genes involved in tumor suppression (p53, Txnrd1, Btg2)...
  13. Liu D, Ji L, Zhao M, Wang Y, Guo Y, Li L, et al. Lysine glycation of apolipoprotein A-I impairs its anti-inflammatory function in type 2 diabetes mellitus. J Mol Cell Cardiol. 2018;122:47-57 pubmed publisher
    ..We identified seven specific lysine (Lys, K) residues of apoA-I (K12, K23, K40, K96, K106, K107 and K238) that were susceptible to be glycated either in vitro or in vivo...
  14. Kaltezioti V, Antoniou D, Stergiopoulos A, Rozani I, Rohrer H, Politis P. Prox1 regulates Olig2 expression to modulate binary fate decisions in spinal cord neurons. J Neurosci. 2014;34:15816-31 pubmed publisher
    ..showed that endogenous Prox1 directly binds to the proximal promoter of the Olig2 gene locus, as well as to the K23 enhancer, which drives Olig2 expression in the pMN domain...
  15. Voßmann S, Wieseler J, Kerber R, Kümmerer B. A basic cluster in the N terminus of yellow fever virus NS2A contributes to infectious particle production. J Virol. 2015;89:4951-65 pubmed publisher
    ..In fact, a region just upstream of R22-K23-R24 was mapped to be critical for NS2A-NS3 interaction...
  16. Strnad P, Guldiken N, Helenius T, Misiorek J, Nyström J, Lähdeniemi I, et al. Simple Epithelial Keratins. Methods Enzymol. 2016;568:351-88 pubmed publisher
    ..SEK filaments are composed of obligate heteropolymers of type II (K7, K8) and type I (K18-K20, K23) keratins...
  17. Walser R, Renshaw J, Milbradt A. Backbone resonance assignments for the PHD-Bromo dual-domain of the human chromatin reader TRIM24. Biomol NMR Assign. 2016;10:207-11 pubmed publisher
    ..histone 3 (H3) N-terminal tails with a specific modification pattern, namely unmethylated at K4 and acetylated at K23 (H3-K4me0K23ac)...
  18. Myers T, Amendola P, Lussi Y, Salcini A. JMJD-1.2 controls multiple histone post-translational modifications in germ cells and protects the genome from replication stress. Sci Rep. 2018;8:3765 pubmed publisher
    ..in the germline where it controls the level of histone 3 lysine 9, lysine 23 and lysine 27 di-methylation (H3K9/K23/K27me2) both in mitotic and meiotic cells. Loss of jmjd-1...
  19. Min L, Zhao Y, Zhu S, Qiu X, Cheng R, Xing J, et al. Integrated Analysis Identifies Molecular Signatures and Specific Prognostic Factors for Different Gastric Cancer Subtypes. Transl Oncol. 2017;10:99-107 pubmed publisher
    ..067] were identified as independent prognostic factors only in diffuse GC but not in intestinal GC patients. KRT23 [RR (95% CI)=1.616 (0.938-2.785), P=...
  20. Kur Piotrowska A, Kopcewicz M, Kozak L, Sachadyn P, Grabowska A, Gawronska Kozak B. Neotenic phenomenon in gene expression in the skin of Foxn1- deficient (nude) mice - a projection for regenerative skin wound healing. BMC Genomics. 2017;18:56 pubmed publisher
    ..E14 and nude mice exhibit prominent up-regulation of keratin (Krt23, -73, -82, -16, -17), involucrin (Ivl) and filaggrin (Flg2) genes...
  21. Okeigwe I, Wang C, Politch J, Heffner L, Kuohung W. Physician-scientists in obstetrics and gynecology: predictors of success in obtaining independent research funding. Am J Obstet Gynecol. 2017;217:84.e1-84.e8 pubmed publisher
    ..of this study is to describe the cohort of obstetrics and gynecology physician-scientists who were K08, K12, and K23 recipients from 1988 through 2015 and to identify predictors of success in obtaining independent federal funding, ..
  22. Jagsi R, Griffith K, Jones R, Stewart A, Ubel P. Factors Associated With Success of Clinician-Researchers Receiving Career Development Awards From the National Institutes of Health: A Longitudinal Cohort Study. Acad Med. 2017;92:1429-1439 pubmed publisher
    ..In 2010-2011 (T1) and 2014 (T2), 1,719 clinician-researchers who received new K08 and K23 awards in 2006-2009 were longitudinally surveyed...
  23. Assrir N, Pavelkova A, Dazzoni R, Ducasse R, Morellet N, Guittet E, et al. Initial Molecular Recognition Steps of McjA Precursor during Microcin J25 Lasso Peptide Maturation. Chembiochem. 2016;17:1851-1858 pubmed publisher
    ..Moreover, we demonstrated that residues K23-Q34 in the N-terminal McjA leader peptide tend to adopt a helical conformation in the presence of membrane mimics, ..
  24. Guldiken N, Kobazi Ensari G, Lahiri P, Couchy G, Preisinger C, Liedtke C, et al. Keratin 23 is a stress-inducible marker of mouse and human ductular reaction in liver disease. J Hepatol. 2016;65:552-9 pubmed publisher
    ..In the present study we aimed to characterize K23 in the liver...
  25. Prabhakaran D, Chowdhury G, Pazhani G, Ramamurthy T, Thomas S. Draft Genome Sequence of an Environmental trh+ Vibrio parahaemolyticus K23 Strain Isolated from Kerala, India. Genome Announc. 2016;4: pubmed publisher
    ..Here, we report the draft genome sequence of atrh(+)strain,V. parahaemolyticusK23, isolated from seafood. The sequence will be useful for comparative analysis between environmental and clinical isolates ofV. parahaemolyticus. ..
  26. Beck Y, Fritz R, Orlinger K, Kiermayr S, Ilk R, Portsmouth D, et al. Molecular Basis of the Divergent Immunogenicity of Two Pediatric Tick-Borne Encephalitis Virus Vaccines. J Virol. 2016;90:1964-72 pubmed publisher
    ..FSME-Immun Junior is based on the Neudörfl (Nd) strain, whereas Encepur Children is based on the Karlsruhe (K23) strain...
  27. Smeeton J, Dhir P, Hu D, Feeney M, Chen L, Rosenblum N. Integrin-linked Kinase Controls Renal Branching Morphogenesis via Dual Specificity Phosphatase 8. J Am Soc Nephrol. 2016;27:1465-77 pubmed publisher
    ..of p38MAPK activity in murine inner medullary collecting duct 3 (mIMCD3) cells decreased expression of Wnt11, Krt23, and Slo4c1 DUSP8 overexpression in mIMCD3 cells significantly inhibited p38MAPK activation and the expression of ..
  28. Narahari A, Mehaffey J, Hawkins R, Baderdinni P, Chandrabhatla A, Tribble C, et al. Cardiothoracic and Vascular Surgeons Achieve High Rates of K Award Conversion Into R01 Funding. Ann Thorac Surg. 2018;106:602-607 pubmed publisher
    ..All K (K08 and K23) grants awarded to surgeons by the NIH between 1992 and 2017 were identified through NIH Research Portfolio Online ..
  29. Li P, Zhang Y, Xie B, Zhang Y, Hao J, Wang Y, et al. Structural and Mechanistic Insights into the Improvement of the Halotolerance of a Marine Microbial Esterase by Increasing Intra- and Interdomain Hydrophobic Interactions. Appl Environ Microbiol. 2017;83: pubmed publisher
    ..M3" represents a mutation in loop 1 of the CAP domain in which residues R22-K23-T24 of E40 are replaced by residues Y22-K23-H24-L25-S26 of Est2...
  30. Buehl C, Deng X, Luo J, Buranasudja V, Hazbun T, Kuo M. A Failsafe for Sensing Chromatid Tension in Mitosis with the Histone H3 Tail in Saccharomyces cerevisiae. Genetics. 2018;208:565-578 pubmed publisher
    ..Mutations to K14 and K23 ameliorate the mitotic defects resulting from TSM mutations...
  31. Broussard E, Kim R, Wiley J, Marquez J, Annis J, Pritchard D, et al. Identification of putative immunologic targets for colon cancer prevention based on conserved gene upregulation from preinvasive to malignant lesions. Cancer Prev Res (Phila). 2013;6:666-74 pubmed publisher
    ..Silencing the most highly upregulated genes, CDH3, CLDN1, KRT23, and MMP7, in adenoma and CRC cell lines resulted in a significant decrease in viability (P < 0...
  32. Yang Q, Feng M, Ma X, Li H, Xie W. Gene expression profile comparison between colorectal cancer and adjacent normal tissues. Oncol Lett. 2017;14:6071-6078 pubmed publisher
    ..However, subsequent gene function studies are required to verify these findings...
  33. Régnier M, Polizzi A, Lippi Y, Fouché E, Michel G, Lukowicz C, et al. Insights into the role of hepatocyte PPARα activity in response to fasting. Mol Cell Endocrinol. 2018;471:75-88 pubmed publisher
    ..Interestingly, we identified novel PPARα-sensitive genes, including Cxcl-10, Rab30, and Krt23. We also found that liver phospholipid remodelling was a novel fasting-sensitive pathway regulated by PPARα...
  34. Wang P, Tang S, Nemr K, Flick R, Yan J, Mahadevan R, et al. Refined experimental annotation reveals conserved corrinoid autotrophy in chloroform-respiring Dehalobacter isolates. ISME J. 2017;11:626-640 pubmed publisher
    ..Similar to D. restrictus strain PER-K23, strains CF and DCA require arginine, histidine and threonine for growth, although the corresponding biosynthesis ..
  35. Birkenkamp Demtroder K, Hahn S, Mansilla F, Thorsen K, Maghnouj A, Christensen R, et al. Keratin23 (KRT23) knockdown decreases proliferation and affects the DNA damage response of colon cancer cells. PLoS ONE. 2013;8:e73593 pubmed publisher
    Keratin 23 (KRT23) is strongly expressed in colon adenocarcinomas but absent in normal colon mucosa...
  36. Fatehi M, Raja M, Carter C, Soliman D, Holt A, Light P. The ATP-sensitive K(+) channel ABCC8 S1369A type 2 diabetes risk variant increases MgATPase activity. Diabetes. 2012;61:241-9 pubmed publisher
    ..human K(ATP) channels or glutathione S-transferase and NBD2 fusion proteins containing the E23/S1369 (nonrisk) or K23/A1369 (risk) variant haplotypes...
  37. Lang V, Fatehi M, Light P. Pharmacogenomic analysis of ATP-sensitive potassium channels coexpressing the common type 2 diabetes risk variants E23K and S1369A. Pharmacogenet Genomics. 2012;22:206-14 pubmed publisher
    ..Our previous studies showed that KATP channel inhibition by the A-site sulfonylurea gliclazide was increased in the K23/A1369 haplotype...
  38. Suzuki A, Ji G, Numabe Y, Muramatsu M, Gomi K, Kanazashi M, et al. Single nucleotide polymorphisms associated with aggressive periodontitis and severe chronic periodontitis in Japanese. Biochem Biophys Res Commun. 2004;317:887-92 pubmed
    ..with severe chronic periodontitis), but also in structural factors of periodontal tissues (COL4A1, COL1A1, and KRT23, associated with aggressive periodontitis; and HSPG2, COL17A1, and EGF, associated with severe chronic ..