KRT20

Summary

Gene Symbol: KRT20
Description: keratin 20
Alias: CD20, CK-20, CK20, K20, KRT21, keratin, type I cytoskeletal 20, cytokeratin 20, keratin 20, type I, protein IT
Species: human
Products:     KRT20

Top Publications

  1. Saad R, Silverman J, Khalifa M, Rowsell C. CDX2, cytokeratins 7 and 20 immunoreactivity in rectal adenocarcinoma. Appl Immunohistochem Mol Morphol. 2009;17:196-201 pubmed publisher
    There are limited data regarding CDX2 expression in rectal carcinoma. The CK20/CK7 immunoprofile of colorectal adenocarcinoma has been described in studies, which have mostly lumped colonic and rectal tumors together...
  2. Bayrak R, Yenidunya S, Haltas H. Cytokeratin 7 and cytokeratin 20 expression in colorectal adenocarcinomas. Pathol Res Pract. 2011;207:156-60 pubmed publisher
    Cytokeratin 7 (CK7) and cytokeratin 20 (CK20) are low molecular weight cytokeratins. The expressions of CK7 and CK20 have been studied in various primary and metastatic carcinomas...
  3. Rados J, Jerković Gulin S, Dotlic S, Basic Kinda S, Ceović R. Folliculotropic Mycosis Fungoides Associated with Autoimmune Hepatitis. Acta Dermatovenerol Croat. 2017;25:248-250 pubmed
    ..analysis of the cells in ascites revealed atypical lymphocytes with convoluted nuclei - LCA+, CD3+, CD20-. The patient died in December 2015 due to sepsis with febrile neutropenia...
  4. Anai S, Hashisako M, Ikegame S, Wakamatsu K, Nagata N, Nakanishi Y, et al. Mantle cell lymphoma involvement of the pleura and tuberculous pleurisy with pulmonary tuberculosis: a case report and literature review. J Infect Chemother. 2012;18:258-64 pubmed publisher
    ..Immunophenotypes were CD5(+), CD10(-), CD19(+), CD20(+), λ(+), CD25(+) by flow cytometry and CD20(+), CD45RO(-), cyclin D1(+), bcl2(+), bcl6(-) by ..
  5. Ram N, Rashid O, Farooq S, Ulhaq I, Islam N. Primary adrenal non-Hodgkin lymphoma: a case report and review of the literature. J Med Case Rep. 2017;11:108 pubmed publisher
    ..Immunohistochemical stains were strongly positive for CD20 and negative for CD3, CD5, CD10, and cyclin D1. The patient's Ki-67 (Mib-1) index was approximately 80%...
  6. Fortofoiu M, Popescu D, Pădureanu V, Dobrinescu A, Dobrinescu A, Mită A, et al. Difficulty in positive diagnosis of ascites and in differential diagnosis of a pulmonary tumor. Rom J Morphol Embryol. 2017;58:1057-1064 pubmed
    ..HRP) method, as well as the antibodies: cytokeratin (CK) cocktail (AE1÷AE3), vimentin, calretinin, CK7, CK5÷6, CK20, epithelial specific antigen/epithelial cell adhesion molecule (Ep-CAM) (BerEP4), thyroid transcription factor-1 (..
  7. Ferrandina G, Palluzzi E, Fanfani F, Gentileschi S, Valentini A, Mattoli M, et al. Endometriosis-associated clear cell carcinoma arising in caesarean section scar: a case report and review of the literature. World J Surg Oncol. 2016;14:300 pubmed
    ..EMA, CKAE1/AE3, CD15, CA-125, while immunoreaction for Calretinin, WT1, estrogen, and progesterone receptors, cytokeratin 20, CD10, alpha fetoprotein, CDX2, TTF1, and thyroglobulin were all negative...
  8. Iwagami M, Furuya R, Tsutsumi D, Mochida Y, Ishioka K, Oka M, et al. True identity of endocapillary proliferation: a case of intravascular large B cell lymphoma diagnosed with immunohistochemical study of kidney biopsy and literature review. CEN Case Rep. 2012;1:61-68 pubmed publisher
    ..staining of the kidney biopsy specimen taken previously to find that endocapillary infiltrating cells were CD20-positive B lymphocytes...
  9. Shimada A, Kohara Y, Naota M, Kobayashi Y, Morita T, Inoue K, et al. Pathological study of chronic pulmonary toxicity induced by intratracheally instilled Asian sand dust (Kosa): possible association of fibrosis with the development of granulomatous lesions. Folia Histochem Cytobiol. 2015;53:294-306 pubmed publisher
    ..actin, collagen III, matrix metalloproteinase-9 (MMP-9), tissue inhibitor of metalloproteinases-1 (TIMP-1), CD3, CD20, immunoglobulin G, interleukin-1β and inducible nitric oxide synthase...

More Information

Publications150 found, 100 shown here

  1. Tajima S, Waki M, Yamazaki H, Nagata Y, Fukano H, Hossen M, et al. Intravascular large B-cell lymphoma manifesting as cholecystitis: report of an Asian variant showing gain of chromosome 18 with concurrent deletion of chromosome 6q. Int J Clin Exp Pathol. 2014;7:8181-9 pubmed
    ..to be localized in the vasculature in both the spleen and gallbladder; the atypical cells expressed high levels of CD20, CD5, and CD10, immunohistochemically. These findings were consistent with IVLBCL...
  2. Foster W, Bischin A, Dorer R, Aboulafia D. Human Herpesvirus Type 8-associated Large B-cell Lymphoma: A Nonserous Extracavitary Variant of Primary Effusion Lymphoma in an HIV-infected Man: A Case Report and Review of the Literature. Clin Lymphoma Myeloma Leuk. 2016;16:311-21 pubmed publisher
    ..biopsy specimen showed malignant large cells with prominent cytoplasm that were positive for pan-B cell antigen CD20, HHV-8, and EBV and negative for CD138, CD10, BCL-6, CD3, and CD30. The Ki-67 labeling index was 90%...
  3. Paolino G, Panetta C, Didona D, Donati M, Donati P. Folliculotropic Cutaneous Metastases and Lymphangitis Carcinomatosa: When Cutaneous Metastases of Breast Carcinoma Are Mistaken for Cutaneous Infections. Acta Dermatovenerol Croat. 2016;24:154-7 pubmed
    ..The tumor cells were positive to cytokeratin (CK) 7, CK19, and carcinoembryonic antigen (CEA) and negative for CK20, CK5/6, CD10, and thyroid transcription factor-1 (TTF-1) (Figure 4)...
  4. Liu R, Lu Z, Gu J, Liu J, Huang E, Liu X, et al. MicroRNAs 15A and 16-1 Activate Signaling Pathways That Mediate Chemotaxis of Immune Regulatory B cells to Colorectal Tumors. Gastroenterology. 2018;154:637-651.e7 pubmed publisher
    ..Mice were given anti-CD20 to delete B cells, or injections of agomir to increase MIR15A and MIR16-1...
  5. Mori R, Futamura M, Morimitsu K, Saigo C, Miyazaki T, Yoshida K. The diagnosis of a metastatic breast tumor from ovarian cancer by the succession of a p53 mutation: a case report. World J Surg Oncol. 2017;15:117 pubmed publisher
    ..of an immunohistochemical analysis were as follows: cancer antigen 125 (CA125 (+)), cytokeratin 7 (CK7 (+)), cytokeratin 20 (CK20 (-)), p53 (+) and CDX2 (-), estrogen receptor (ER (slightly +)), progesterone receptor (PR (slightly +)),..
  6. Moreira D, da Silva R, Vieira J, Fattah T, Lueneberg M, Gottschall C. Role of vascular inflammation in coronary artery disease: potential of anti-inflammatory drugs in the prevention of atherothrombosis. Inflammation and anti-inflammatory drugs in coronary artery disease. Am J Cardiovasc Drugs. 2015;15:1-11 pubmed publisher
    ..The blockage of other potential targets, such as the IL-6 receptor, CC2 chemokine receptor and CD20, could bring benefits in CAD.
  7. Astorri E, Nerviani A, Bombardieri M, Pitzalis C. Towards a stratified targeted approach with biologic treatments in rheumatoid arthritis: role of synovial pathobiology. Curr Pharm Des. 2015;21:2216-24 pubmed
    ..The same limitation can be applied to the use of rituximab, a chimeric monoclonal antibody directed against CD20, which is uniquely expressed by all B-lymphocytes during the maturation process from late stage pro-B cells to ..
  8. Samoon Z, Idrees R, Masood N, Ansari T. Plasmablastic lymphoma of the oral cavity with breast recurrence: a case report. BMC Res Notes. 2015;8:180 pubmed publisher
    ..An excisional biopsy revealed CD20, CD3, and CD117 negative and CD138, CD79a, CD56, MUM1/IFR4 and CD30 positive lesion with Ki-67 of 60% with cells ..
  9. Waisberg J, Anderi A, Cardoso P, Borducchi J, Germini D, Franco M, et al. Extensive colorectal lymphomatous polyposis complicated by acute intestinal obstruction: a case report. J Med Case Rep. 2017;11:190 pubmed publisher
    ..Immunohistochemical analysis revealed positive immunostaining for CD79a, CD20, and CD45. These results were consistent with the diagnosis of mantle cell lymphoma...
  10. Wotherspoon A, Attygalle A, Mendes L. Bone marrow and splenic histology in hairy cell leukaemia. Best Pract Res Clin Haematol. 2015;28:200-7 pubmed publisher
    ..In this context staining for CD20 may be used in conjunction with morphological assessment and staining of serial sections for cyclin D1 and DBA44 to ..
  11. Dammacco F, Racanelli V, Russi S, Sansonno D. The expanding spectrum of HCV-related cryoglobulinemic vasculitis: a narrative review. Clin Exp Med. 2016;16:233-42 pubmed publisher
    ..In those with refractory and relapsing disease, addition of the anti-CD20 monoclonal antibody rituximab has significantly increased the overall response rates...
  12. Zhang X, Ma Z, Cui W, Pang X, Chen R, Wang L, et al. [Impact of PRDM1 gene inactivation on C-MYC regulation in diffuse large B-cell lymphoma]. Zhonghua Bing Li Xue Za Zhi. 2018;47:25-31 pubmed publisher
    ..Immunohistochemical methods were used to detect the expression of CD20, CD10, MUM1, Ki-67, bcl-6, PRDM1/Blimp1, C-MYC and PAX5 protein...
  13. Gajendra S, Sharma R, Sahoo M. Triple cancer: chronic lymphocytic leukemia with bladder and prostate carcinoma. Malays J Pathol. 2015;37:159-63 pubmed
    ..immunophenotyping revealed 75% abnormal lymphoid cells which were positive for CD 19, CD5, CD23, CD22, CD200, CD20 (moderate) with lambda light chain restriction and negative for CD3, CD10, FMC7, CD38, CD138, IgM, CD103, CD123...
  14. Matsuo T, Tanaka T, Ichimura K, Meguri Y. Intraocular Relapse with Hypopyon and Retinal Infiltrates after Chemotherapy and Peripheral Blood Stem Cell Transplantation for Extranodal NK/T-Cell Lymphoma. J Clin Exp Hematop. 2015;55:157-61 pubmed publisher
    ..by anterior chamber paracentesis, were positive for CD3, CD56, and Epstein-Barr virus-encoded RNA, but negative for CD20 by immunocytochemical staining...
  15. Grajales Cruz A, Bacó Viera F, Rive Mora E, Ramirez Tanchez C, Tasso D, Arroyo Portela N, et al. Primary Adrenal Angiosarcoma: A Rare and Potentially Misdiagnosed Tumor. Cancer Control. 2017;24:198-201 pubmed
    ..negative for S100, protein Melan-A, CD34, synaptophysin, chromogranin, desmin, muscle specific actin, ETFA (EMA), KRT20 (CK20), CDX2, TTF1, LNPEP (PLAP), inhibin, ?-fetoprotein, CD30, hepatocyte paraffin, and aberrant expression of ..
  16. Kapoor P, Paludo J, Ansell S. Waldenstrom Macroglobulinemia: Familial Predisposition and the Role of Genomics in Prognosis and Treatment Selection. Curr Treat Options Oncol. 2016;17:16 pubmed publisher
    Waldenstrom macroglobulinemia (WM) is a non-Hodgkin lymphoma (NHL) characterized by the presence of a CD20 + lymphoplasmacytic bone marrow (BM) infiltrate and serum immunoglobulin M monoclonal protein...
  17. Zhao K, Dai G, Zhu J. Ascites as the initial characteristic manifestation in a patient with primary gastric CD8-positive diffuse large B-cell lymphoma. Eur Rev Med Pharmacol Sci. 2016;20:1707-11 pubmed
    ..Pathology test showed lymphocytes with atypical hyperplasia, and immunohistochemistry test resulted CD20+, CD10-, CD79α+, κ+, bcl-6+, Ki-67+ (approximately 95%), λ-, bcl-2-, CD3-, CD43-...
  18. El Khadragy M, Nabil H, Hassan B, Tohamy A, Waaer H, Yehia H, et al. Bone Marrow Cell Therapy on 1,2-Dimethylhydrazine (DMH)-Induced Colon Cancer in Rats. Cell Physiol Biochem. 2018;45:1072-1083 pubmed publisher
    ..Gene expression in rat colon tissue demonstrated that BMCs down-regulated survivin, β-catenin, MDR-1 and cytokeratin 20 genes expression in colon tissues after colon cancer induction...
  19. Niculescu Z, Ulmeanu V, Ghinea M, Mocanu L, Niculescu C, Grigorian M. Gallbladder carcinoma - a rare cause of pyloric-duodenal stenosis. Rom J Morphol Embryol. 2016;57:1165-1170 pubmed
    ..Immunohistochemical tests [cytokeratin (CK) 7, CK17, CK19, CK20, CDX2, mucin (MUC) 1, MUC2, MUC5AC, MUC6, epithelial membrane antigen (EMA) and carcinoembryonic antigen (CEA)] ..
  20. Demir E, Karaoglan C, Yegen G, Sair B, Yazici H, Turkmen A, et al. Extreme hypercalcemia in a kidney transplant recipient. CEN Case Rep. 2018;: pubmed publisher
    ..A bone marrow biopsy showed diffuse interstitial infiltration of CD20 + neoplastic B cells and, thus, post transplant lymphoproliferative disease (PTLD) was diagnosed...
  21. Bonamichi Santos R, Castells M. Diagnoses and Management of Drug Hypersensitivity and Anaphylaxis in Cancer and Chronic Inflammatory Diseases: Reactions to Taxanes and Monoclonal Antibodies. Clin Rev Allergy Immunol. 2018;54:375-385 pubmed publisher
    ..Monoclonal antibody targets include CD20, HER-2, EGFR, IL-6 receptor, TNF-?, CD30, VEGF-A, IgE, and more, and examples of immune-mediated and inflammatory ..
  22. Zhou H, Liu L, Yu G, Qu G, Gong P, Yu X, et al. Analysis of Clinicopathological Features and Prognostic Factors in 39 Cases of Bladder Neuroendocrine Carcinoma. Anticancer Res. 2017;37:4529-4537 pubmed
    ..In contrast, cytokeratin 20 (CK20), protein 63 (P63), human melanoma black 45 (HMB45), S-lfln protein 100 (S-100) and leukocyte common ..
  23. Srikakulapu P, Hu D, Yin C, Mohanta S, Bontha S, Peng L, et al. Artery Tertiary Lymphoid Organs Control Multilayered Territorialized Atherosclerosis B-Cell Responses in Aged ApoE-/- Mice. Arterioscler Thromb Vasc Biol. 2016;36:1174-85 pubmed publisher
    ..ATLOs versus atherosclerotic lesions: ATLOs showed upregulation of bona fide B-cell genes, including Cd19, Ms4a1 (Cd20), Cd79a/b, and Ighm although intima plaques preferentially expressed molecules involved in non-B effector responses ..
  24. Chiereghin A, Bertuzzi C, Piccirilli G, Gabrielli L, Squarzoni D, Turello G, et al. Successful management of EBV-PTLD in allogeneic bone marrow transplant recipient by virological-immunological monitoring of EBV infection, prompt diagnosis and early treatment. Transpl Immunol. 2016;34:60-4 pubmed publisher
    ..load equal to 119,039copies/mL whole blood, +56day after transplant) led to administration of pre-emptive anti-CD20 monoclonal antibody (rituximab) and close clinical monitoring...
  25. Zhang C, Yi Y, Chen C, Wang J, Liu Z. Discordant lymphoma consisting of mediastinal large B-cell lymphoma and nodular sclerosis Hodgkin lymphoma in the right supraclavicular lymph nodes: a case report. Diagn Pathol. 2015;10:215 pubmed publisher
    ..nuclei as well as a high percentage of mitotic cells; strongly positive immunohistochemical staining for PAX5, CD20, and CD79a also was observed...
  26. Yin L, Xu J, Li M, Reddy V, Zhou Q, Liu H, et al. Oct2 and Bob1 are sensitive and specific markers in lineage determination of B cell lymphomas with no expression of conventional B cell markers. Histopathology. 2016;69:775-783 pubmed publisher
    Rare cases of B cell lymphomas do not express conventional B cell markers (CD20, CD79a and PAX5), and these types of lymphomas include anaplastic lymphoma kinase (ALK)-positive large B cell lymphoma, plasmablastic lymphoma, primary ..
  27. Bonifant C, Szöor A, Torres D, Joseph N, Velasquez M, Iwahori K, et al. CD123-Engager T Cells as a Novel Immunotherapeutic for Acute Myeloid Leukemia. Mol Ther. 2016;24:1615-26 pubmed publisher
    ..We therefore introduced the CD20 suicide gene that can be targeted in vivo with rituximab into CD123-ENG T cells...
  28. Slot L, Hoogeboom R, Smit L, Wormhoudt T, Biemond B, Oud M, et al. B-Lymphoblastic Lymphomas Evolving from Follicular Lymphomas Co-Express Surrogate Light Chains and Mutated Gamma Heavy Chains. Am J Pathol. 2016;186:3273-3284 pubmed publisher
    ..We describe four extraordinary cases of FL, which progressed to TdT+CD20- precursor B-lymphoblastic lymphoma (B-LBL)...
  29. Mohajeri G, Hejab K, Sheikhbahaei S, Mohajeri M, Niknam N, Mohammadi A. Micrometastasis in colorectal cancer: does it affect staging?. ANZ J Surg. 2016;: pubmed publisher
    ..Liver and BM biopsy were obtained during the surgery to be looked for tissue-specific marker of CRC, CK20. CK20 expression in BM and liver was assessed by the two methods of reverse transcriptase polymerase chain reaction ..
  30. Remo A, Grillo F, Mastracci L, Fassan M, Sina S, Zanella C, et al. Clear cell colorectal carcinoma: Time to clarify diagnosis. Pathol Res Pract. 2017;213:447-452 pubmed publisher
    ..of an aggressive neoplasm, affecting mainly adult men, characterized by an intestinal-type immunoprofile (CK20+, CK7-, CEA+, CDX-2+) and b) Müllerian CCC consisting of an indolent carcinoma of the sigmoid-rectum, affecting ..
  31. López Montañés M, Alari Pahissa E, Sintes J, Martinez Rodriguez J, Muntasell A, Lopez Botet M. Antibody-Dependent NK Cell Activation Differentially Targets EBV-Infected Cells in Lytic Cycle and Bystander B Lymphocytes Bound to Viral Antigen-Containing Particles. J Immunol. 2017;199:656-665 pubmed publisher
    ..In that case, target cell damage appeared marginal compared with the effect of a control anti-CD20 Ab (rituximab) at concentrations that triggered similar NK cell activation, indicating that cell-associated gp350<..
  32. Dinescu Å, ForÅ¢ofoiu M, Bumbea A, Ciurea P, Busuioc C, MuÅŸetescu A. Histopathological and immunohistochemical profile in primary Sjögren's syndrome. Rom J Morphol Embryol. 2017;58:409-417 pubmed
    ..Specimens with important CD20+ B-cell component of lymphocytic infiltrate were associated with intermediate and severe FS grade...
  33. Thota R, Gonzalez R, Berlin J, Cardin D, Shi C. Could the PD-1 Pathway Be a Potential Target for Treating Small Intestinal Adenocarcinoma?. Am J Clin Pathol. 2017;148:208-214 pubmed publisher
    ..Tumors were immunohistochemically stained for CD3, CD4, CD8, CD20, PD-1, and programmed death ligand 1 (PD-L1) expression...
  34. Badr G, Ramadan N, Abdel Tawab H, Ahmed S, Mahmoud M. Camel whey protein protects lymphocytes from apoptosis via the PI3K/AKT, NF-?B, ATF-3 and HSP-70 signaling pathways in heat-stressed male mice. Biochem Cell Biol. 2017;: pubmed publisher
    ..AKT and I?B-? phosphorylation; increased ATF-3 and HSP70 expression; and aberrant distribution of CD3+ T cells and CD20+ B cells in the thymus and spleen...
  35. Eichenauer D, Engert A. Nodular lymphocyte-predominant Hodgkin lymphoma: a unique disease deserving unique management. Hematology Am Soc Hematol Educ Program. 2017;2017:324-328 pubmed publisher
    ..Histologically, the disease-defining lymphocyte predominant cells consistently express CD20 but lack CD30...
  36. Hu J, Guo X, Yang L. Morin inhibits proliferation and self-renewal of CD133+ melanoma cells by upregulating miR-216a. J Pharmacol Sci. 2018;136:114-120 pubmed publisher
    ..miR-216a overexpression reduced cell viability, sphere formation ability and expressions of stem cell marker genes CD20, CD44, CD133 and Wnt-3A. MiR-216a was induced by Morin treatment in CD133+ melanoma cells...
  37. Canioni D, Deau Fischer B, Taupin P, Ribrag V, Delarue R, Bosq J, et al. Prognostic significance of new immunohistochemical markers in refractory classical Hodgkin lymphoma: a study of 59 cases. PLoS ONE. 2009;4:e6341 pubmed publisher
    ..We evaluated 59 patients (18 with primary refractory or early relapse disease and 41 responders) for bcl2, Ki67, CD20, TiA1 and c-kit expression by semi-quantitative immunohistochemical study and correlated the results with the ..
  38. Kamei K, Yasuda T, Satoi S, Ishikawa H, Sakamoto H, Kitano M, et al. Intrapancreatic gastric duplication cyst mimicking pancreatic cystic tumor. Clin J Gastroenterol. 2013;6:156-9 pubmed publisher
    ..analysis revealed the columnar epithelium to be immunopositive for cytokeratin 7 (CK7) and immunonegative for cytokeratin 20 (CK20) and the glands to be immunonegative for CK 7 and immunopositive for CK 20...
  39. Fujii H, Yamaguchi K, Ohnishi N, Sakamoto M, Ohkawara T, Sawa Y, et al. Adenoendocrine cell carcinoma of the gallbladder producing a high level of alpha-fetoprotein. Clin J Gastroenterol. 2012;5:261-7 pubmed publisher
    ..positive for cytokeratin 19, focally positive for cytokeratin 7, but negative for hepatocyte paraffin 1 and cytokeratin 20, suggestive of biliary tract carcinoma...
  40. Lidický O, Janoušková O, Strohalm J, Alam M, Klener P, Etrych T. Anti-Lymphoma Efficacy Comparison of Anti-Cd20 Monoclonal Antibody-Targeted and Non-Targeted Star-Shaped Polymer-Prodrug Conjugates. Molecules. 2015;20:19849-64 pubmed publisher
    ..high-molecular-weight (HMW) polymer prodrugs with a dendrimer core and a targeted conjugate with the anti-CD20 monoclonal antibody (mAb) rituximab (RTX)...
  41. Galletti G, Scielzo C, Barbaglio F, Rodriguez T, Riba M, Lazarevic D, et al. Targeting Macrophages Sensitizes Chronic Lymphocytic Leukemia to Apoptosis and Inhibits Disease Progression. Cell Rep. 2016;14:1748-1760 pubmed publisher
    ..CSF1R inhibition reduces leukemic cell load, especially in the bone marrow, and increases circulating CD20(+) leukemic cells...
  42. England C, Rui L, Cai W. Lymphoma: current status of clinical and preclinical imaging with radiolabeled antibodies. Eur J Nucl Med Mol Imaging. 2017;44:517-532 pubmed publisher
    ..Currently, there are two common biomarkers for molecular imaging of lymphoma, CD20 and CD30, both of which have been considered for investigation in preclinical imaging studies...
  43. Camacho X, Machado C, Garcia M, Gambini J, Banchero A, Fernandez M, et al. Technetium-99m- or Cy7-Labeled Rituximab as an Imaging Agent for Non-Hodgkin Lymphoma. Oncology. 2017;92:229-242 pubmed publisher
    ..was the first monoclonal antibody approved for the treatment of B-cell non-Hodgkin lymphoma (NHL) expressing CD20 antigen...
  44. Skenderi F, Ulamec M, Vanecek T, Martinek P, Alaghehbandan R, Foix M, et al. Warthin-like papillary renal cell carcinoma: Clinicopathologic, morphologic, immunohistochemical and molecular genetic analysis of 11 cases. Ann Diagn Pathol. 2017;27:48-56 pubmed publisher
    ..Tumors were mostly negative for carboanhydrase 9, CD117, CK20, and TTF-1...
  45. Fillatreau S. B cells and their cytokine activities implications in human diseases. Clin Immunol. 2018;186:26-31 pubmed publisher
    ..Together with current data on the effect of anti-CD20 B cell-depleting reagents in the clinic, this novel knowledge on B cell heterogeneity opens the way for novel safer ..
  46. Jovanovic I, Tzardi M, Mouzas I, Micev M, Pesko P, Milosavljevic T, et al. Changing pattern of cytokeratin 7 and 20 expression from normal epithelium to intestinal metaplasia of the gastric mucosa and gastroesophageal junction. Histol Histopathol. 2002;17:445-54 pubmed publisher
    ..Data from recent studies regarding the expression of cytokeratin CK7 and CK20 in intestinal metaplasia (IM) found at the gastroesophageal junction are conflicting...
  47. Hartley J, Chu T, Peterson E, Zhang R, Yang J, Harris J, et al. Super-Resolution Imaging and Quantitative Analysis of Membrane Protein/Lipid Raft Clustering Mediated by Cell-Surface Self-Assembly of Hybrid Nanoconjugates. Chembiochem. 2015;16:1725-9 pubmed publisher
    ..The nanoconjugates crosslinked CD20 on the surface of malignant B cells, thereby inducing apoptosis...
  48. Fleury I, Chevret S, Pfreundschuh M, Salles G, Coiffier B, van Oers M, et al. Rituximab and risk of second primary malignancies in patients with non-Hodgkin lymphoma: a systematic review and meta-analysis. Ann Oncol. 2016;27:390-7 pubmed publisher
    Addition of the anti-CD20 monoclonal antibody rituximab to chemotherapy improves response rates and survival in patients with B-cell non-Hodgkin lymphoma (NHL)...
  49. Audoly G, Fenollar F, Lagier J, Lepidi H, Raoult D. Deglycosylation of Tropheryma whipplei biofilm and discrepancies between diagnostic results during Whipple's disease progression. Sci Rep. 2016;6:23883 pubmed publisher
    ..We showed the presence of bacteria in both CK20(+) epithelial cells and CD68(+) macrophages. Bacteria are found embedded in a biofilm hindering the detection of T...
  50. Bortolotti M, Bolognesi A, Battelli M, Polito L. High in Vitro Anti-Tumor Efficacy of Dimeric Rituximab/Saporin-S6 Immunotoxin. Toxins (Basel). 2016;8: pubmed publisher
    The anti-CD20 mAb Rituximab has revolutionized lymphoma therapy, in spite of a number of unresponsive or relapsing patients...
  51. Farhadfar N, Litzow M. New monoclonal antibodies for the treatment of acute lymphoblastic leukemia. Leuk Res. 2016;49:13-21 pubmed publisher
    ..The antigens CD19, CD20, CD22 and CD52, are the most common antigens to which monoclonal antibodies in B-cell ALL have been directed...
  52. Aguado Domínguez E, Gómez L, Sousa J, Gómez Bravo M, Núñez Roldán A, Aguilera I. Identification of the cellular components involved in de novo immune hepatitis: a quantitative immunohistochemical analysis. J Transl Med. 2018;16:62 pubmed publisher
    ..6% in the dnIH group versus 49.4% in the CR group. CD20+ B lymphocytes represented 14.9% in the dnIH group and 29.1% in the CR group...
  53. Dharan M. The adjunctive value of CD10 immunostaining on cell block preparations in pelvic endometriosis. Acta Cytol. 2009;53:625-9 pubmed
    ..Immunocytochemistry using monoclonal antibodies for cytokeratin (CK) 7, CK20, CD10, estrogen receptor (ER), progesterone receptor (PR) and CA125 was performed on sections from cell blocks ..
  54. Chatzipantelis P, Mastorakis E, Tzortzakakis D, Salla C. Fine needle aspiration cytology diagnosis of primary renal lymphoma involving the pleura: a case report. Acta Cytol. 2010;54:71-4 pubmed
    ..Immunocytochemically, the neoplastic cells were: CD45 (LCA) (+), CD20 (+), CK7 (-), CK20 (-), NSE (-), CD45 RO (UCHL-1) (-) and CD30 (-)...
  55. Tanaka S, Martling A, Lindholm J, Holm T, Palmer G. Remaining cancer cells within the fibrosis after neo-adjuvant treatment for locally advanced rectal cancer. Eur J Surg Oncol. 2015;41:1204-9 pubmed publisher
    ..In addition, immunohistochemical staining with CK20 was done to examine if cancer cells were missed by routine pathological work up...
  56. Visoná I, Sementilli A, Kuschnaroff L, Franco M. Medullary nephritis in the diagnosis of acute cellular rejection. Pathol Res Pract. 2015;211:811-5 pubmed publisher
    ..We performed immunohistochemistry (IHC) of the cells composing the inflammatory foci, using anti-CD4, CD8, CD20, CD68, and CD138 antibodies, respectively for T-helper cells, cytotoxic T cells, B lymphocytes, macrophages and ..
  57. Hirpara J, Loh T, Ng S, Chng W, Pervaiz S. Aberrant localization of apoptosis protease activating factor-1 in lipid raft sub-domains of diffuse large B cell lymphomas. Oncotarget. 2016;7:83964-83975 pubmed publisher
    ..in the clinical management of diffuse B cell lymphomas despite aggressive chemotherapy such as CHOP and monoclonal CD20. Here we provide evidence that the apoptosome adaptor protein, Apaf-1, is mislocalized in primary cells derived ..
  58. Tang T, Yang Z, Zhang D, Qu J, Liu G, Zhang S. Clinicopathological study of 9 cases of prostate cancer involving the rectal wall. Diagn Pathol. 2017;12:8 pubmed publisher
    ..analysis for CDX-2, prostate-specific antigen (PSA), P504s, villin, carcinoembryonic antigen, CK-pan, cytokeratin 20, and Ki-67...
  59. Baumer T, Fry C, Luppe S, Gunawardena H, Sieradzan K. Human herpes virus-6 encephalitis causing severe anterograde amnesia associated with rituximab, azathioprine and prednisolone combination therapy for dermatomyositis. J Neurovirol. 2017;23:508-510 pubmed publisher
    ..The anti-CD20 B cell depleting monoclonal antibody, rituximab is now increasingly used, often in combination with conventional ..
  60. Choi J, Cho H, Kang S, Jang S, Yoo E, Cho H, et al. Intravascular large B-cell lymphoma associated with myelofibrosis: A case report. Mol Clin Oncol. 2017;7:798-802 pubmed publisher
    ..result for CD79a and negative results for terminal deoxynucleotidyl transferase, myeloperoxidase, CD3, CD10, CD20, B-cell lymphoma (Bcl)-2, Bcl-6 and cytomegalovirus. The patient was diagnosed with IVLBCL complicated by MF...
  61. Niknam F, Chen J, Napaki S, Aghmesheh M. Approach to multiple pulmonary nodules: a case report and review of literature. ScientificWorldJournal. 2011;11:760-5 pubmed publisher
    ..reported scant atypical epithelial cells that stained positive for TTF-1 and cytokeratin 7, but negative for cytokeratin 20. Thus, it was suspicious for large cell carcinoma...
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    ..We observed that the density of HEV blood vessels was increased in CLL LNs and that CD20(+) CLL cells accumulated within HEV pockets, suggesting intense trafficking...
  63. Gil deeva G, Kudlai D, Luk yanov S. [THE MECHANISMS OF ACTION OF RITUXIMAB]. Eksp Klin Farmakol. 2015;78:51-6 pubmed
    ..This modified immunoglobulin structure makes rituximab capable of specifically recognizing CD20 antigen that is mainly expressed on B-lymphocytes...
  64. Richter M, Yumul R, Saydaminova K, Wang H, Gough M, Baldessari A, et al. Preclinical safety, pharmacokinetics, pharmacodynamics, and biodistribution studies with Ad35K++ protein: a novel rituximab cotherapeutic. Mol Ther Methods Clin Dev. 2016;5:16013 pubmed publisher
    Rituximab is a mouse/human chimeric monoclonal antibody targeted toward CD20. It is efficient as first-line therapy of CD20-positive B-cell malignancies...
  65. Zhu M, Wan W, Li H, Wang Y, Wang J, Ling H, et al. [Correlation between Expression of CD200 and Regulatory T Cells in Multiple Myeloma and Its Significance in Prognostic Stratification]. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2016;24:1427-1432 pubmed publisher
    ..CD200 and other immunophenotypes, including CD38, CD138, CD56, CD19, CD20, CD117, cytoplasm light chain Kappa and Lambda in bone marrow samples, and Tregs in peripheral blood were detected ..
  66. Garcia Sanz R, Jimenez C, Puig N, Paiva B, Gutierrez N, Rodriguez Otero P, et al. Origin of Waldenstrom's macroglobulinaemia. Best Pract Res Clin Haematol. 2016;29:136-147 pubmed publisher
    ..This immunophenotype matches memory B cells (smIgM-/+/CD10-/CD19+/CD20+/CD27+/CD38low+/CD45+), representing 30% of B cells in the blood...
  67. Vivarelli M, Massella L, Ruggiero B, Emma F. Minimal Change Disease. Clin J Am Soc Nephrol. 2017;12:332-345 pubmed publisher
    ..Recent therapeutic advances, such as the use of anti-CD20 antibodies, have provided long-term remission off-therapy and suggest new hypotheses for disease pathogenesis.
  68. Khomula E, Ferrari L, Araldi D, Levine J. Sexual Dimorphism in a Reciprocal Interaction of Ryanodine and IP3 Receptors in the Induction of Hyperalgesic Priming. J Neurosci. 2017;37:2032-2044 pubmed publisher
    ..depolarization-induced transients produced by extracellular application of high-potassium solution (20 mm, K20), in nociceptors incubated with ?-estradiol...
  69. Gales J, Prayson R. Chronic inflammation in refractory hippocampal sclerosis-related temporal lobe epilepsy. Ann Diagn Pathol. 2017;30:12-16 pubmed publisher
    ..inflammation observed on hematoxylin and eosin stained sections, there was a mixture of both T (CD3+) and B (CD20+) lymphocytes located around blood vessels and interspersed within the brain parenchyma and a predominance of CD4 ..
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    ..including biopsy of the lesion (histological study, immunohistochemistry for CD68 + , CD4 + , CD8 + , CD20 + , MCT +, and cytomegalovirus, PAS, Grocott-Gomori and Zielh-Neelsen staining, and in situ hybridization for ..
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    ..Similar to breast cancer, basal and luminal subtype UCas are designated by basal (CK5/14) and luminal (CK20) markers...
  72. Mochizuki K, Kondo T, Tahara I, Inoue T, Kasai K, Oishi N, et al. Signet ring cell carcinoma of the non-ampullary duodenum: A case report. Pathol Res Pract. 2015;211:801-4 pubmed publisher
    ..Cytokeratin 7 was focally positive, but cytokeratin 20 was negative. Nuclear staining of p53 was diffusely and weakly positive...
  73. Bae J, Rhee Y, Kim K, Wen X, Song Y, Cho N, et al. Are clinicopathological features of colorectal cancers with methylation in half of CpG island methylator phenotype panel markers different from those of CpG island methylator phenotype-high colorectal cancers?. Hum Pathol. 2016;47:85-94 pubmed publisher
    ..8/8 methylated markers in terms of sex distribution, mucin production, serration, nodal metastasis, CK7 expression, CK20 loss, and CDX2 loss frequencies and overall survival rate...
  74. Kroeger D, Milne K, Nelson B. Tumor-Infiltrating Plasma Cells Are Associated with Tertiary Lymphoid Structures, Cytolytic T-Cell Responses, and Superior Prognosis in Ovarian Cancer. Clin Cancer Res. 2016;22:3005-15 pubmed publisher
    ..However, the prognostic effect of CD8(+) TIL is markedly higher in the presence of CD20(+) B cells, suggesting that cooperative interactions between these lymphocyte subsets lead to more potent antitumor ..
  75. Marshall D, Harried S, Murphy J, Hall C, Shekhani M, Pain C, et al. Extracellular Antibody Drug Conjugates Exploiting the Proximity of Two Proteins. Mol Ther. 2016;24:1760-1770 pubmed publisher
    ..We demonstrate that a potent small molecule inhibitor of the NKA can be covalently attached to antibodies targeting CD20, CD38, CD56, CD147, or dysadherin, to create a series of selective and powerful EDCs that kill cancer cells ..
  76. Tommola P, Unkila Kallio L, Paetau A, Meri S, Kalso E, Paavonen J. Immune activation enhances epithelial nerve growth in provoked vestibulodynia. Am J Obstet Gynecol. 2016;215:768.e1-768.e8 pubmed publisher
    ..Nerve growth factor was analyzed by counting the staining-positive immune cells. Antibodies against CD20 (B lymphocytes) and CD3 (T lymphocytes) were used to identify and locate mucosal areas with increased density of ..
  77. Willcox A, Richardson S, Walker L, Kent S, Morgan N, Gillespie K. Germinal centre frequency is decreased in pancreatic lymph nodes from individuals with recent-onset type 1 diabetes. Diabetologia. 2017;60:1294-1303 pubmed publisher
    ..5 years duration) type 1 diabetes (n=13), and longer-duration type 1 diabetes (n=15). Staining for CD3, CD20 and Ki67 was used to detect primary and secondary (germinal centre-containing) follicles and CD21 and CD35 to ..
  78. Polito L, Mercatelli D, Bortolotti M, Maiello S, Djemil A, Battelli M, et al. Two Saporin-Containing Immunotoxins Specific for CD20 and CD22 Show Different Behavior in Killing Lymphoma Cells. Toxins (Basel). 2017;9: pubmed publisher
    ..The cytotoxicity of two immunotoxins obtained by chemical conjugation of the plant toxin saporin-S6 with the anti-CD20 chimeric antibody rituximab and the anti-CD22 murine antibody OM124 were evaluated on the CD20-/CD22-positive cell ..
  79. Li L, Molberg K, Cheedella N, Thibodeaux J, Hinson S, Lucas E. The diagnostic utility of Merkel cell polyomavirus immunohistochemistry in a fine needle aspirate of metastatic Merkel cell carcinoma of unknown primary to the pancreas. Diagn Cytopathol. 2018;46:67-71 pubmed publisher
    ..The tumor cells were positive with pancytokeratin AE1/AE3, CK20, CD56, synatophysin, chromogranin, and Merkel cell polyomavirus (MCPyV)...
  80. Malara N, Trunzo V, Foresta U, Amodio N, De Vitis S, Roveda L, et al. Ex-vivo characterization of circulating colon cancer cells distinguished in stem and differentiated subset provides useful biomarker for personalized metastatic risk assessment. J Transl Med. 2016;14:133 pubmed publisher
    ..blood of seven patients affected by colon cancer, expressing CD133(pos)CD45(neg) (5 ± 1) and (2 ± 1) and CK20(pos)CD45(neg) of (29 ± 3) (11 ± 1) cells/ml in Dukes D and A stage respectively...
  81. Kronbichler A, Windpessl M, Pieringer H, Jayne D. Rituximab for immunologic renal disease: What the nephrologist needs to know. Autoimmun Rev. 2017;16:633-643 pubmed publisher
    Rituximab (RTX), a chimeric, monoclonal anti-CD20 antibody, is increasingly used in immune-mediated renal diseases...
  82. Yoon J, Wang H, Kim Y, Yoshimoto M, Abbasi S, Morse Iii H. Plasma cell alloantigen ENPP1 is expressed by a subset of human B cells with potential regulatory functions. Immunol Cell Biol. 2016;94:719-28 pubmed publisher
    ..characteristics of human PC1(+) B cells differ from mouse peritoneal B-1a subsets and from features of the human CD20(+)CD27(+)CD43(+)CD70(-) B-cell subset proposed to be human B-1 cells...
  83. Mine S, Hishima T, Suganuma A, Fukumoto H, Sato Y, Kataoka M, et al. Interleukin-6-dependent growth in a newly established plasmablastic lymphoma cell line and its therapeutic targets. Sci Rep. 2017;7:10188 pubmed publisher
    ..Morphological assessment of PBL-1 indicated plasma-cell differentiation with a CD20(-) CD38(+) CD138(+) immunophenotype and IgH/c-myc translocation...
  84. Innocenti I, Autore F, Pasquale R, Morelli F, Efremov D, Laurenti L. Treatment approach for elderly and unfit patients with chronic lymphocytic leukemia. Expert Rev Hematol. 2017;:1-8 pubmed publisher
    ..The addition of a monoclonal anti-CD20 antibody to Chl substantially increases response rates and prolongs progression-free survival (PFS) in these ..
  85. Qiao J, Meng X, Zhang J, Qi L, Liang Y, Sun J. [Expression of CK20 mRNA in the peripheral blood around postoperative chemotherapy in patients with gastric cancer and its clinical significance]. Zhonghua Wei Chang Wai Ke Za Zhi. 2009;12:32-5 pubmed
    To investigate whether CK20 mRNA expression level could be considered as an effective molecular indicator for evaluation of chemotherapy sensitivity...
  86. AbdullGaffar B, Seliem R. De Novo Unclassifiable CD20-Negative Diffuse Large B-Cell Lymphoma: A Diagnostic and Therapeutic Challenge. Int J Surg Pathol. 2017;:1066896917735170 pubmed publisher
    b>CD20-negative diffuse large B-cell lymphomas (DLBCLs) constitute a rare and heterogeneous group of aggressive lymphomas...
  87. Suzuki Y, Tanaka H, Suyama K, Mochida H, Suzuki Y. Secondary Central Nerve System Lymphoma With Intratumoral Hemorrhage Suggested as Intravascular Lymphoma by Autopsy: A Case Report. J Clin Med Res. 2017;9:953-957 pubmed publisher
    ..Furthermore, the autopsy revealed a discrepancy in the CD20 immunostaining of lymphoma cells between the brain and other organs...
  88. McCormick S, Tong Z, Ivask A, Morozesk M, Voelcker N, Lombi E, et al. Optimization of binding B-lymphocytes in a microfluidic channel: surface modification, stasis time and shear response. Biofabrication. 2017;: pubmed publisher
    ..a self-assembled monolayer of 3-(glycidyloxypropyl)trimethoxysilane (GPTMS) before covalently immobilizing anti-CD20 antibody...
  89. Krüger R, Borte S, von Weizsäcker K, Wahn V, Feiterna Sperling C. Positive KREC newborn screening in a neonate with intrauterine exposure to rituximab. Scand J Immunol. 2017;: pubmed publisher
    ..Newborns exposed to rituximab (RTX; anti-CD20-antibody) due to maternal therapy during pregnancy may be identified as immunodeficient with B-cell lymphopenia ..
  90. Gerdes M, Gokmen Polar Y, Sui Y, Pang A, LaPlante N, Harris A, et al. Single-cell heterogeneity in ductal carcinoma in situ of breast. Mod Pathol. 2017;: pubmed publisher
    ..analysis of 11 disease-related markers (EGFR, HER2, HER4, S6, pmTOR, CD44v6, SLC7A5 and CD10, CD4, CD8 and CD20, plus pan-cytokeratin, pan-cadherin, DAPI, and Na+K+ATPase for cell segmentation)...
  91. Barrett A, Cort E, Patel P, Berkovitz B. An immunohistological study of cytokeratin 20 in human and mammalian oral epithelium. Arch Oral Biol. 2000;45:879-87 pubmed
    ..In addition, double-labelling experiments were undertaken to determine the association between CK 20 expression and that of CK 8/18 or S100 protein...
  92. Wirt T, Rosskopf S, Rösner T, Eichholz K, Kahrs A, Lutz S, et al. An Fc Double-Engineered CD20 Antibody with Enhanced Ability to Trigger Complement-Dependent Cytotoxicity and Antibody-Dependent Cell-Mediated Cytotoxicity. Transfus Med Hemother. 2017;44:292-300 pubmed publisher
    ..whether complement-dependent cytotoxicity (CDC) and antibody-dependent cell-mediated cytotoxicity (ADCC) of CD20 antibodies could be improved simultaneously by combining Fc protein engineering and glyco-engineering technologies.