KRIT1

Summary

Gene Symbol: KRIT1
Description: KRIT1, ankyrin repeat containing
Alias: CAM, CCM1, krev interaction trapped protein 1, ankyrin repeat-containing protein Krit1, cerebral cavernous malformations 1 protein, krev interaction trapped 1
Species: human
Products:     KRIT1

Top Publications

  1. Tsutsumi S, Ogino I, Miyajima M, Ikeda T, Shindo N, Yasumoto Y, et al. Genomic causes of multiple cerebral cavernous malformations in a Japanese population. J Clin Neurosci. 2013;20:667-9 pubmed publisher
    ..of CCM are thought to arise in association with genomic mutations in the cerebral cavernous malformation 1 (CCM1) (KRIT1), CCM2 (MGC4607), and CCM3 (PDCD10) genes...
  2. Sahoo T, Johnson E, Thomas J, Kuehl P, Jones T, Dokken C, et al. Mutations in the gene encoding KRIT1, a Krev-1/rap1a binding protein, cause cerebral cavernous malformations (CCM1). Hum Mol Genet. 1999;8:2325-33 pubmed
    ..Using a genomic sequence-based positional cloning strategy, we have identified KRIT1, encoding a protein that interacts with the Krev-1/rap1a tumor suppressor, as the CCM1 gene...
  3. D Angelo R, Marini V, Rinaldi C, Origone P, Dorcaratto A, Avolio M, et al. Mutation analysis of CCM1, CCM2 and CCM3 genes in a cohort of Italian patients with cerebral cavernous malformation. Brain Pathol. 2011;21:215-24 pubmed publisher
    ..Familial cases are associated with mutations in CCM1[K-Rev interaction trapped 1 (KRIT1)], CCM2 (MGC4607) and CCM3 (PDCD10) genes...
  4. Eerola I, Plate K, Spiegel R, Boon L, Mulliken J, Vikkula M. KRIT1 is mutated in hyperkeratotic cutaneous capillary-venous malformation associated with cerebral capillary malformation. Hum Mol Genet. 2000;9:1351-5 pubmed
    ..The first mutations were identified in the CCM1 gene (located on 7q21-22), which encodes KRIT1 protein (KREV1 interaction trapped 1), presumably a membrane-bound protein with signalling activity...
  5. Zhang J, Clatterbuck R, Rigamonti D, Dietz H. Cloning of the murine Krit1 cDNA reveals novel mammalian 5' coding exons. Genomics. 2000;70:392-5 pubmed
    Human KRIT1 (Krev interaction trapped 1), a defective gene product in cerebral cavernous malformation, was cloned from a HeLa cell cDNA library by virtue of its interaction with Krev/rap1A, a small ras-family GTPase...
  6. Voss K, Stahl S, Schleider E, Ullrich S, Nickel J, Mueller T, et al. CCM3 interacts with CCM2 indicating common pathogenesis for cerebral cavernous malformations. Neurogenetics. 2007;8:249-56 pubmed
    Individuals carrying a mutation in one of the three cerebral cavernous malformation genes (CCM1/KRIT1, CCM2, CCM3) cannot be clinically distinguished, raising the possibility that they act within common molecular pathways...
  7. Denier C, Gasc J, Chapon F, Domenga V, Lescoat C, Joutel A, et al. Krit1/cerebral cavernous malformation 1 mRNA is preferentially expressed in neurons and epithelial cells in embryo and adult. Mech Dev. 2002;117:363-7 pubmed
    ..Three CCM loci have been mapped, and the sole gene identified so far, CCM1, has been shown to encode KRIT1, a protein of unknown function...
  8. Laberge Le Couteulx S, Jung H, Labauge P, Houtteville J, Lescoat C, Cecillon M, et al. Truncating mutations in CCM1, encoding KRIT1, cause hereditary cavernous angiomas. Nat Genet. 1999;23:189-93 pubmed
    ..Here we report a physical and transcriptional map of this interval and that CCM1, a gene whose protein product, KRIT1, interacts with RAP1A (also known as KREV1; ref...
  9. Lampugnani M, Orsenigo F, Rudini N, Maddaluno L, Boulday G, Chapon F, et al. CCM1 regulates vascular-lumen organization by inducing endothelial polarity. J Cell Sci. 2010;123:1073-80 pubmed publisher
    ..b>CCM1 is encoded by the CCM1 gene, which is mutated in 60% of patients affected by cerebral cavernous malformation (CCM)...

More Information

Publications82

  1. Sirvente J, Enjolras O, Wassef M, Tournier Lasserve E, Labauge P. Frequency and phenotypes of cutaneous vascular malformations in a consecutive series of 417 patients with familial cerebral cavernous malformations. J Eur Acad Dermatol Venereol. 2009;23:1066-72 pubmed publisher
    ..Three genes (KRIT1/CCM1, MGC4607/CCM2, PDCD10/CCM3) have been identified so far...
  2. Akers A, Johnson E, Steinberg G, Zabramski J, Marchuk D. Biallelic somatic and germline mutations in cerebral cavernous malformations (CCMs): evidence for a two-hit mechanism of CCM pathogenesis. Hum Mol Genet. 2009;18:919-30 pubmed publisher
    ..Familial cases follow autosomal-dominant inheritance due to mutations in one of three genes, CCM1/KRIT1, CCM2/malcavernin or CCM3/PDCD10...
  3. Gunel M, Laurans M, Shin D, DiLuna M, Voorhees J, Choate K, et al. KRIT1, a gene mutated in cerebral cavernous malformation, encodes a microtubule-associated protein. Proc Natl Acad Sci U S A. 2002;99:10677-82 pubmed
    Mutations in Krev1 interaction trapped gene 1 (KRIT1) cause cerebral cavernous malformation, an autosomal dominant disease featuring malformation of cerebral capillaries resulting in cerebral hemorrhage, strokes, and seizures...
  4. Zhang J, Clatterbuck R, Rigamonti D, Chang D, Dietz H. Interaction between krit1 and icap1alpha infers perturbation of integrin beta1-mediated angiogenesis in the pathogenesis of cerebral cavernous malformation. Hum Mol Genet. 2001;10:2953-60 pubmed
    ..b>Krev Interaction Trapped 1 (krit1) was originally identified through its interaction with the Ras-family GTPase krev1/rap1a in a ..
  5. Zawistowski J, Serebriiskii I, Lee M, Golemis E, Marchuk D. KRIT1 association with the integrin-binding protein ICAP-1: a new direction in the elucidation of cerebral cavernous malformations (CCM1) pathogenesis. Hum Mol Genet. 2002;11:389-96 pubmed
    Mutations in KRIT1, a protein initially identified based on a yeast two-hybrid interaction with the RAS-family GTPase RAP1A, are responsible for the development of the inherited vascular disorder cerebral cavernous malformations (CCM1)...
  6. Stahl S, Gaetzner S, Voss K, Brackertz B, Schleider E, Sürücü O, et al. Novel CCM1, CCM2, and CCM3 mutations in patients with cerebral cavernous malformations: in-frame deletion in CCM2 prevents formation of a CCM1/CCM2/CCM3 protein complex. Hum Mutat. 2008;29:709-17 pubmed publisher
    ..a combination of direct sequencing and MLPA analyses, we identified 15 novel and eight previously published CCM1 (KRIT1), CCM2, and CCM3 (PDCD10) mutations...
  7. Serebriiskii I, Estojak J, Sonoda G, Testa J, Golemis E. Association of Krev-1/rap1a with Krit1, a novel ankyrin repeat-containing protein encoded by a gene mapping to 7q21-22. Oncogene. 1997;15:1043-9 pubmed
    ..multiple isolates coding for a previously undescribed protein which we have designated Kritl (for Krev Interaction Trapped 1)...
  8. Liu J, Stockton R, Gingras A, Ablooglu A, Han J, Bobkov A, et al. A mechanism of Rap1-induced stabilization of endothelial cell--cell junctions. Mol Biol Cell. 2011;22:2509-19 pubmed publisher
    ..of Rap1 small GTPases stabilizes cell--cell junctions, and this activity requires Krev Interaction Trapped gene 1 (KRIT1)...
  9. Glading A, Han J, Stockton R, Ginsberg M. KRIT-1/CCM1 is a Rap1 effector that regulates endothelial cell cell junctions. J Cell Biol. 2007;179:247-54 pubmed
    ..malformation (CCM), a disease associated with defective endothelial junctions, result from autosomal dominant CCM1 mutations that cause loss of KRIT-1 protein function, though how the loss of KRIT-1 leads to CCM is obscure...
  10. Béraud Dufour S, Gautier R, Albiges Rizo C, Chardin P, Faurobert E. Krit 1 interactions with microtubules and membranes are regulated by Rap1 and integrin cytoplasmic domain associated protein-1. FEBS J. 2007;274:5518-32 pubmed
    ..b>Krev interaction trapped 1 (Krit1), a protein with FERM (band four-point-one/ezrin/radixin/moesin) domain, was identified as a Rap1 ..
  11. Penco S, Ratti R, Bianchi E, Citterio A, Patrosso M, Marocchi A, et al. Molecular screening test in familial forms of cerebral cavernous malformation: the impact of the Multiplex Ligation-dependent Probe Amplification approach. J Neurosurg. 2009;110:929-34 pubmed publisher
    ..Ligation-dependent Probe Amplification analysis integrates the consecutive sequence analysis of the 3 genes (Krit1/CCM1, MGC4607/CCM2, and PDCD10/CCM3) known to be responsible for cerebral cavernous malformation lesions...
  12. Gianfrancesco F, Cannella M, Martino T, Maglione V, Esposito T, Innocenzi G, et al. Highly variable penetrance in subjects affected with cavernous cerebral angiomas (CCM) carrying novel CCM1 and CCM2 mutations. Am J Med Genet B Neuropsychiatr Genet. 2007;144B:691-5 pubmed
    ..origin and investigating the genetic basis of the disorder we disclosed two novel molecular variations in the KRIT1 and MGC4607 genes...
  13. Zhang J, Rigamonti D, Dietz H, Clatterbuck R. Interaction between krit1 and malcavernin: implications for the pathogenesis of cerebral cavernous malformations. Neurosurgery. 2007;60:353-9; discussion 359 pubmed
    ..Mutations in krit1 and malcavernin, the proteins encoded by the genes at the CCM1 and CCM2 loci, respectively, are responsible for ..
  14. Stockton R, Shenkar R, Awad I, Ginsberg M. Cerebral cavernous malformations proteins inhibit Rho kinase to stabilize vascular integrity. J Exp Med. 2010;207:881-96 pubmed publisher
    ..malformations (CCMs) in humans result from mutations of CCM2 (malcavernin, OSM, MGC4607), PDCD10 (CCM3), or KRIT1 (CCM1), a Rap1 effector which stabilizes endothelial cell-cell junctions...
  15. Verlaan D, Davenport W, Stefan H, Sure U, Siegel A, Rouleau G. Cerebral cavernous malformations: mutations in Krit1. Neurology. 2002;58:853-7 pubmed
    To find mutations in the recently identified additional exons of the Krit1 gene that causes CCM1, a disease characterized by the formation of cerebral cavernous malformations (CCM)...
  16. Kitzmann A, Pulido J, Ferber M, Highsmith W, Babovic Vuksanovic D. A splice-site mutation in CCM1/KRIT1 is associated with retinal and cerebral cavernous hemangioma. Ophthalmic Genet. 2006;27:157-9 pubmed
    To report a case of a unilateral retinal cavernous hemangioma associated with a novel splice-site mutation in CCM1/KRIT1.
  17. Guarnieri V, Muscarella L, Amoroso R, Quattrone A, Abate M, Coco M, et al. Identification of two novel mutations and of a novel critical region in the KRIT1 gene. Neurogenetics. 2007;8:29-37 pubmed
    ..Mutations in three genes (KRIT1, MGC4607, and PDCD10) have been associated with CCMs...
  18. Wüstehube J, Bartol A, Liebler S, Brütsch R, Zhu Y, Felbor U, et al. Cerebral cavernous malformation protein CCM1 inhibits sprouting angiogenesis by activating DELTA-NOTCH signaling. Proc Natl Acad Sci U S A. 2010;107:12640-5 pubmed publisher
    ..CCM1 (also known as KRIT1) stabilizes endothelial junctions and is essential for vascular morphogenesis in mouse embryos...
  19. Verlaan D, Laurent S, Sure U, Bertalanffy H, Andermann E, Andermann F, et al. CCM1 mutation screen of sporadic cases with cerebral cavernous malformations. Neurology. 2004;62:1213-5 pubmed
    ..The CCM1 gene was screened in 35 sporadic cases with either single or multiple CCM...
  20. Guzeloglu Kayisli O, Amankulor N, Voorhees J, Luleci G, Lifton R, Gunel M. KRIT1/cerebral cavernous malformation 1 protein localizes to vascular endothelium, astrocytes, and pyramidal cells of the adult human cerebral cortex. Neurosurgery. 2004;54:943-9; discussion 949 pubmed
    Mutations in KRIT1 cause familial cerebral cavernous malformation, an autosomal dominant disorder affecting primarily the central nervous system vasculature...
  21. Sahoo T, Goenaga Diaz E, Serebriiskii I, Thomas J, Kotova E, Cuellar J, et al. Computational and experimental analyses reveal previously undetected coding exons of the KRIT1 (CCM1) gene. Genomics. 2001;71:123-6 pubmed
    ..An important such case has been found with KRIT1, the cerebral cavernous malformation type 1 (CCM1) gene...
  22. Goitre L, Balzac F, Degani S, Degan P, Marchi S, Pinton P, et al. KRIT1 regulates the homeostasis of intracellular reactive oxygen species. PLoS ONE. 2010;5:e11786 pubmed publisher
    b>KRIT1 is a gene responsible for Cerebral Cavernous Malformations (CCM), a major cerebrovascular disease characterized by abnormally enlarged and leaky capillaries that predispose to seizures, focal neurological deficits, and fatal ..
  23. Verlaan D, Siegel A, Rouleau G. Krit1 missense mutations lead to splicing errors in cerebral cavernous malformation. Am J Hum Genet. 2002;70:1564-7 pubmed
    At least 40% of families affected with cerebral cavernous malformation have a mutation in Krit1. We previously identified two point mutations in Krit1 leading to changes in amino acids (D137G and Q210E) in two different families...
  24. Pagenstecher A, Stahl S, Sure U, Felbor U. A two-hit mechanism causes cerebral cavernous malformations: complete inactivation of CCM1, CCM2 or CCM3 in affected endothelial cells. Hum Mol Genet. 2009;18:911-8 pubmed publisher
    ..Familial cerebral cavernous malformations (CCMs) have been associated with germline mutations in CCM1/KRIT1, CCM2 or CCM3/PDCD10...
  25. Zhang J, Basu S, Rigamonti D, Dietz H, Clatterbuck R. Krit1 modulates beta 1-integrin-mediated endothelial cell proliferation. Neurosurgery. 2008;63:571-8; discussion 578 pubmed publisher
    Using ribonucleic acid interference on cultured cell lines, we examined the role of Krev interaction trapped 1 (krit1) and integrin cytoplasmic domain-associated protein-1 alpha (icap1alpha) in beta1-integrin-mediated cell proliferation...
  26. Zawistowski J, Stalheim L, Uhlik M, Abell A, Ancrile B, Johnson G, et al. CCM1 and CCM2 protein interactions in cell signaling: implications for cerebral cavernous malformations pathogenesis. Hum Mol Genet. 2005;14:2521-31 pubmed
    ..Familial CCM is caused by mutations in KRIT1 (CCM1) or in malcavernin (CCM2), the murine ortholog of which was concurrently characterized as osmosensing ..
  27. Gault J, Shenkar R, Recksiek P, Awad I. Biallelic somatic and germ line CCM1 truncating mutations in a cerebral cavernous malformation lesion. Stroke. 2005;36:872-4 pubmed
    ..CCMs are sporadic or inherited and 3 genes (CCM1, CCM2, and CCM3) have been identified. However, the role of somatic mutation in CCM genesis has been disputed...
  28. Reich P, Winkler J, Straube A, Steiger H, Peraud A. Molecular genetic investigations in the CCM1 gene in sporadic cerebral cavernomas. Neurology. 2003;60:1135-8 pubmed
    ..Mutations in Krit1, a gene located at the CCM1 locus on chromosome 7q21, account for the majority of familial CCM cases...
  29. Kehrer Sawatzki H, Wilda M, Braun V, Richter H, Hameister H. Mutation and expression analysis of the KRIT1 gene associated with cerebral cavernous malformations (CCM1). Acta Neuropathol. 2002;104:231-40 pubmed
    ..In patients with cavernomas, constitutional mutations of the KRIT1 gene have been identified...
  30. Couteulx S, Brezin A, Fontaine B, Tournier Lasserve E, Labauge P. A novel KRIT1/CCM1 truncating mutation in a patient with cerebral and retinal cavernous angiomas. Arch Ophthalmol. 2002;120:217-8 pubmed
  31. Labauge P, Krivosic V, Denier C, Tournier Lasserve E, Gaudric A. Frequency of retinal cavernomas in 60 patients with familial cerebral cavernomas: a clinical and genetic study. Arch Ophthalmol. 2006;124:885-6 pubmed
    ..To define the frequency of retinal lesions in a large panel of patients with familial cerebral cavernomas and to screen the cerebral cavernous malformation genes in patients with cerebral and retinal lesions...
  32. Seker A, Pricola K, Guclu B, Ozturk A, Louvi A, Gunel M. CCM2 expression parallels that of CCM1. Stroke. 2006;37:518-23 pubmed
    ..tissues by Western blot analysis as well as immunohistochemistry and compared these results with CCM1 (KRIT1) protein expression...
  33. Lyngby J, Court M, Lee P. Validation of a method for quantitation of the clopidogrel active metabolite, clopidogrel, clopidogrel carboxylic acid, and 2-oxo-clopidogrel in feline plasma. J Vet Cardiol. 2017;19:384-395 pubmed publisher
    The clopidogrel active metabolite (CAM) is unstable and challenging to quantitate...
  34. Shepherd M, Rouse E. The VSPA Foot: A Quasi-Passive Ankle-Foot Prosthesis With Continuously Variable Stiffness. IEEE Trans Neural Syst Rehabil Eng. 2017;25:2375-2386 pubmed publisher
    ..The customizable torque-angle curve is obtained with a cam-based transmission and a fiberglass leaf spring...
  35. Radi I, Alfahd A. A technique for retrieving cement-retained implant prostheses. J Prosthet Dent. 2016;116:848-850 pubmed publisher
    ..The procedure could be extrapolated to computer-aided designed and computer-aided manufactured (CAD-CAM) implant prostheses, whereby a CAD-CAM index could be fabricated on the digital model.
  36. Kania Richmond A, Metcalfe A. Integrative health care - What are the relevant health outcomes from a practice perspective? A survey. BMC Complement Altern Med. 2017;17:548 pubmed publisher
    ..An online survey of Canadian IHC clinics. Survey questions were informed by the IN-CAM Health Outcomes Database. Descriptive statistics were used to summarize the data...
  37. Tran Q, Firkins R, Giles J, Francis S, Matnishian V, Tran P, et al. Estrogen Enhances Linkage in the Vascular Endothelial Calmodulin Network via a Feedforward Mechanism at the G Protein-coupled Estrogen Receptor 1. J Biol Chem. 2016;291:10805-23 pubmed publisher
    Estrogen exerts many effects on the vascular endothelium. Calmodulin (CaM) is the transducer of Ca(2+) signals and is a limiting factor in cardiovascular tissues...
  38. Murray I, Lease H, Hetem R, Mitchell D, Fuller A, Woodborne S. Stable isotope analysis of diet confirms niche separation of two sympatric species of Namib Desert lizard. Integr Zool. 2016;11:60-75 pubmed publisher
    ..data estimating the trophic transfer of nutrients in ectotherms in mixed C3 and C4 /crassulacean acid metabolism (CAM) plant landscapes, we found that our lizard species primarily acquired nutrients that originated from C4 /CAM ..
  39. Pedrollo Lise D, Van Ende A, De Munck J, Umeda Suzuki T, Cardoso Vieira L, Van Meerbeek B. Biomechanical behavior of endodontically treated premolars using different preparation designs and CAD/CAM materials. J Dent. 2017;59:54-61 pubmed publisher
    ..5-mm deep endocrown', '5-mm deep endocrown' or '5-mm deep post&crown') and CAD/CAM material type (composite or lithium disilicate glass-ceramic) on the load-to-failure of endodontically treated ..
  40. Sorrentino R, Triulzio C, Tricarico M, Bonadeo G, Gherlone E, Ferrari M. In vitro analysis of the fracture resistance of CAD-CAM monolithic zirconia molar crowns with different occlusal thickness. J Mech Behav Biomed Mater. 2016;61:328-333 pubmed publisher
    To compare the fracture resistance and mode of failure of CAD-CAM monolithic zirconia crowns with different occlusal thickness...
  41. Nguyen T, Combarnous Y, Praud C, Duittoz A, Blesbois E. Ca2+/Calmodulin-Dependent Protein Kinase Kinases (CaMKKs) Effects on AMP-Activated Protein Kinase (AMPK) Regulation of Chicken Sperm Functions. PLoS ONE. 2016;11:e0147559 pubmed publisher
    ..changes in the AMPK regulation pathway, sperm motility and AR related to Ca(2+) entry in sperm through the Ca(2+)/CaM/CaMKKs/CaMKI pathway...
  42. Rhee T, Ng J, Dusek J. Utilization and perceived benefits of homeopathy and herbal therapies in U.S. adults: Implications of patient-centered care. Complement Ther Clin Pract. 2017;29:9-15 pubmed publisher
    ..combination of both treatment and wellness had higher likelihood of reporting benefits, compared to those who used CAM for treatment only (p < 0.001)...
  43. Åžeker E, Ozcelik T, Rathi N, Yilmaz B. Evaluation of marginal fit of CAD/CAM restorations fabricated through cone beam computerized tomography and laboratory scanner data. J Prosthet Dent. 2016;115:47-51 pubmed publisher
    ..tomography (CBCT) images can be used for the fabrication of computer-aided design/computer-aided manufacturing (CAD/CAM) restorations is unknown...
  44. Popov S, Krishna U, Falck J, Wilkie T. Ca2+/Calmodulin reverses phosphatidylinositol 3,4, 5-trisphosphate-dependent inhibition of regulators of G protein-signaling GTPase-activating protein activity. J Biol Chem. 2000;275:18962-8 pubmed
    ..Ca(2+)/calmodulin competition with PIP(3) may provide an intracellular mechanism for feedback regulation of Ca(2+) signaling evoked by G protein-coupled agonists. ..
  45. Altman E, Chandan V, Harrison B, Vinogradov E. Structural and immunological characterization of a glycoconjugate based on the delipidated lipopolysaccharide from a nontypeable Helicobacter pylori strain PJ1 containing an extended d-glycero-d-manno-heptan. Carbohydr Res. 2018;456:19-23 pubmed publisher
    ..LPS) from a nontypeable Helicobacter pylori strain PJ1 and two corresponding mutants, PJ1 HP1283:cam and PJ1 HP1284:cam, was performed using a combination of NMR and mass spectrometric techniques...
  46. Chkheidze R, Sanders M, Haley B, Leitch A, Sahoo S. Isolated Contralateral Axillary Lymph Node Involvement in Breast Cancer Represents a Locally Advanced Disease Not Distant Metastases. Clin Breast Cancer. 2018;18:298-304 pubmed publisher
    ..Breast cancer metastatic to contralateral axillary lymph node (CAM) without metastases to any other distant organ is currently assigned M1 status (stage IV) instead of N3 (stage III)...
  47. Strizich G, Gammon M, Jacobson J, Wall M, Abrahamson P, Bradshaw P, et al. Latent class analysis suggests four distinct classes of complementary medicine users among women with breast cancer. BMC Complement Altern Med. 2015;15:411 pubmed publisher
    Breast cancer patients commonly report using >1 form of complementary and alternative medicine (CAM). However, few studies have attempted to analyze predictors and outcomes of multiple CAM modalities...
  48. da Cunha L, Gonzaga C, Pissaia J, Correr G. Lithium silicate endocrown fabricated with a CAD-CAM system: A functional and esthetic protocol. J Prosthet Dent. 2017;118:131-134 pubmed publisher
    ..Computer-aided design and computer-aided manufacturing (CAD-CAM) systems can generate and store libraries of teeth with various anatomies in their database, and diagnostic tooth ..
  49. Crawford A, Liekens S, Kamuhabwa A, Maes J, Munck S, Busson R, et al. Zebrafish bioassay-guided natural product discovery: isolation of angiogenesis inhibitors from East African medicinal plants. PLoS ONE. 2011;6:e14694 pubmed publisher
    ..migration, and tube formation in vitro, as well as angiogenesis in the chick chorioallantoic membrane (CAM) assay...
  50. Wang N, Chen L, Wang Y. Mathematical Modeling and Deconvolution of Molecular Heterogeneity Identifies Novel Subpopulations in Complex Tissues. Methods Mol Biol. 2018;1751:223-236 pubmed publisher
    ..novel) subpopulations, we develop a novel unsupervised deconvolution method, Convex Analysis of Mixtures (CAM), within a well-grounded mathematical framework, to dissect mixed gene expressions in heterogeneous tissue samples...
  51. Ziemba B, Swisher G, Masson G, Burke J, Williams R, Falke J. Regulation of a Coupled MARCKS-PI3K Lipid Kinase Circuit by Calmodulin: Single-Molecule Analysis of a Membrane-Bound Signaling Module. Biochemistry. 2016;55:6395-6405 pubmed
    ..This study asks whether calmodulin (CaM), which is known to directly bind MARCKS, also stimulates PIP3 production by releasing free PIP2
  52. Xu J, Yu L, Minobe E, Lu L, Lei M, Kameyama M. PKA and phosphatases attached to the Ca(V)1.2 channel regulate channel activity in cell-free patches. Am J Physiol Cell Physiol. 2016;310:C136-41 pubmed publisher
    Calmodulin (CaM) + ATP can reprime voltage-gated L-type Ca(2+) channels (Ca(V)1.2) in inside-out patches for activation, but this effect decreases time dependently. This suggests that the Ca(V)1...
  53. Richert R, Goujat A, Venet L, Viguie G, Viennot S, Robinson P, et al. Intraoral Scanner Technologies: A Review to Make a Successful Impression. J Healthc Eng. 2017;2017:8427595 pubmed publisher
    To overcome difficulties associated with conventional techniques, impressions with IOS (intraoral scanner) and CAD/CAM (computer-aided design and manufacturing) technologies were developed for dental practice...
  54. Henshall D, Araki T, Schindler C, Shinoda S, Lan J, Simon R. Expression of death-associated protein kinase and recruitment to the tumor necrosis factor signaling pathway following brief seizures. J Neurochem. 2003;86:1260-70 pubmed
    ..In contrast, within surviving fields of the hippocampus, DAP kinase interacted with the molecular chaperone 14-3-3. These data suggest DAP kinase is involved in the molecular pathways activated during seizure-induced neuronal death. ..
  55. River J, McKenzie H, Levy D, Pavlakis N, Back M, Oh B. Convergent priorities and tensions: a qualitative study of the integration of complementary and alternative therapies with conventional cancer treatment. Support Care Cancer. 2018;26:1791-1797 pubmed publisher
    Demand for complementary and alternative medicine (CAM) is high among cancer patients...
  56. Sieck G, Han Y, Pabelick C, Prakash Y. Temporal aspects of excitation-contraction coupling in airway smooth muscle. J Appl Physiol (1985). 2001;91:2266-74 pubmed
    ..When calmodulin (CaM) was added, this delay was shortened to approximately 500 ms...
  57. Baatsch B, Zimmer S, Rodrigues Recchia D, Büssing A. Complementary and alternative therapies in dentistry and characteristics of dentists who recommend them. Complement Ther Med. 2017;35:64-69 pubmed publisher
    The aims of this study were to analyse whether dentists offer or recommend complementary and alternative medicine (CAM) remedies in their clinical routine, and how effective these are rated by proponents and opponents...
  58. Lin M, Alnaggar M, Liang S, Shi J, Niu L, Chen J, et al. Using circulating tumor cells to evaluate the efficacy of irreversible electroporation for unresectasble pancreatic cancer. Immunol Res. 2018;66:172-178 pubmed publisher
    ..01). Delta cycle threshold values for the CTC-related genes CEA, Ep-CAM, and CK19 increased significantly after IRE...
  59. Bai Y, Bai L, Zhou J, Chen H, Zhang L. Sequential delivery of VEGF, FGF-2 and PDGF from the polymeric system enhance HUVECs angiogenesis in vitro and CAM angiogenesis. Cell Immunol. 2018;323:19-32 pubmed publisher
    ..human umbilical vein endothelial cells (HUVECs) angiogenic differentiation in vitro and chorioallantoic membrane (CAM) angiogenesis in vivo...
  60. Kwok J, Kwan J, Auyeung M, Mok V, Chan H. The effects of yoga versus stretching and resistance training exercises on psychological distress for people with mild-to-moderate Parkinson's disease: study prxotocol for a randomized controlled trial. Trials. 2017;18:509 pubmed publisher
    ..Thus, adopting a Complementary and Alternative Management (CAM) approach to address this problem is important...
  61. Ates S, Yesil Duymus Z, Çağlar İ, Hologlu B. The effect of veneering on the marginal fit of CAD/CAM-generated, copy-milled, and cast metal copings. Clin Oral Investig. 2017;21:2553-2560 pubmed publisher
    ..Using CAD/CAM, ten (n = 10) each s/c zirconia (NZ) copings and ten (n = 10) each s/c metal (MM) copings were generated...
  62. Kim M, Yoo S, Kang S, Kwon J, Choi I, Lee C. TNF? and IL-1? in the synovial fluid facilitate mucosal-associated invariant T (MAIT) cell migration. Cytokine. 2017;99:91-98 pubmed publisher
    ..elevated in synovial fluid (SF) of RA patients, which resulted in increased expression of E-selectin, ICAM-1 and V-CAM-1 on blood vessel endothelial cells...
  63. Zhang J, Dubey P, Padarti A, Zhang A, Patel R, Patel V, et al. Novel functions of CCM1 delimit the relationship of PTB/PH domains. Biochim Biophys Acta Proteins Proteom. 2017;1865:1274-1286 pubmed publisher
    Three NPXY motifs and one FERM domain in CCM1 makes it a versatile scaffold protein for tethering the signaling components together within the CCM signaling complex (CSC). The cellular role of CCM1 protein remains inadequately expounded...
  64. Oberortner E, Cheng J, Hillson N, Deutsch S. Streamlining the Design-to-Build Transition with Build-Optimization Software Tools. ACS Synth Biol. 2017;6:485-496 pubmed publisher
    ..Current biological computer-aided design and manufacture tools (bioCAD/CAM) do not adequately consider the limitations of DNA synthesis technologies when generating their outputs...
  65. Khan M, Alrawashdeh A, Aljohani S, Zhao Y, Lagowski J. DFT investigation of the interaction between single-walled carbon nanotubes and fluorene-based conjugated oligomers. Phys Chem Chem Phys. 2017;19:28071-28082 pubmed publisher
    ..Four DFT methods are used in this work: the long range (LR)-corrected CAM-B3LYP, the dispersion (D)-corrected B97D, the LR- and D-corrected wB97XD, and the hybrid B3LYP...
  66. Signal L, Stanley J, Smith M, Barr M, Chambers T, Zhou J, et al. Children's everyday exposure to food marketing: an objective analysis using wearable cameras. Int J Behav Nutr Phys Act. 2017;14:137 pubmed publisher
    ..This paper reports on innovative research, Kids'Cam, in which children wore cameras to examine the frequency and nature of everyday exposure to food marketing across ..
  67. Zhang R, Chen C, Xiao L, Sun J, Ma Y, Yang X, et al. Aberrant alterations of the expressions and S-nitrosylation of calmodulin and the downstream factors in the brains of the rodents during scrapie infection. Prion. 2017;11:352-367 pubmed publisher
    The aberrant alterations of calmodulin (CaM) and its downstream substrates have been reported in some neurodegenerative diseases, but rarely described in prion disease...
  68. Kattge S, Goetz K, Glassen K, Steinhäuser J. Job Profile of Non-Medical Practitioners: A Cross- Sectional Study from the Health Service Perspective. Complement Med Res. 2017;24:285-289 pubmed publisher
    The demand for complementary and alternative medicine (CAM) is rising. The German 'Heilpraktiker' is a non-medical naturopathic practitioner (NMNP) providing CAM...
  69. Kambappa V, Chandrashekara G, Rekha N, Shivaramu P, Palle K. Synthesis, anti-angiogenic and DNA cleavage studies of novel N-(4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)piperidine-4-carboxamide derivatives. Chem Cent J. 2017;11:122 pubmed publisher
    ..efficacy of these derivatives to inhibit in vivo angiogenesis was evaluated using chick chorioallantoic membrane (CAM) model and their DNA cleavage abilities were evaluated after incubating with calf thymus DNA followed by gel ..
  70. Zhang X, Yang W, Wang J, Meng Y, Guan Y, Yang J. FAM3 gene family: A promising therapeutical target for NAFLD and type 2 diabetes. Metabolism. 2018;81:71-82 pubmed publisher
    ..FAM3C is a new hepatokine that activates HSF1-CaM-Akt pathway and represses mTOR-SREBP1-FAS pathway to suppress hepatic gluconeogenesis and lipogenesis...
  71. Rosentritt M, Preis V, Behr M, Hahnel S. Influence of preparation, fitting, and cementation on the vitro performance and fracture resistance of CAD/CAM crowns. J Dent. 2017;65:70-75 pubmed publisher
    To investigate debonding and stability of CAD/CAM composite crowns as a function of (a) preparation design, (b) fitting parameters of the milling process, and (c) type of cementation...
  72. Fukui T, Rahman M, Ohde S, Hoshino E, Kimura T, Urayama K, et al. Reassessing the Ecology of Medical Care in Japan. J Community Health. 2017;: pubmed publisher
    ..visit a physician's office, 117 seek help from a professional provider of complementary or alternative medicine (CAM), 70 visit a hospital outpatient clinic (60 community-based and 10 university-based), 6 are hospitalized, and 4 ..
  73. Cooper R, Mengoni M, Groves D, Williams S, Bankes M, Robinson P, et al. Three-dimensional assessment of impingement risk in geometrically parameterised hips compared with clinical measures. Int j numer method biomed eng. 2017;33: pubmed publisher
    ..Standard 2-dimensional radiographic measurements for diagnosis of hip deformities, such as cam deformities on the femoral neck, do not capture the full joint geometry and are not indicative of symptomatic ..