Gene Symbol: KNSTRN
Description: kinetochore localized astrin (SPAG5) binding protein
Alias: C15orf23, HSD11, SKAP, TRAF4AF1, small kinetochore-associated protein, TRAF4 associated factor 1, kinastrin, kinetochore-localized astrin-binding protein, small kinetochore associated protein, small kinetochore-associated protein, kinetochore-localized astrin-binding protein, TRAF4 associated factor 1
Species: human
Products:     KNSTRN

Top Publications

  1. Fang L, Seki A, Fang G. SKAP associates with kinetochores and promotes the metaphase-to-anaphase transition. Cell Cycle. 2009;8:2819-27 pubmed
    ..We report here the identification and characterization of a G(2)-induced gene, SKAP, as a regulator for the anaphase onset. SKAP localizes to spindle MTs and kinetochores in mitosis...
  2. Dunsch A, Linnane E, Barr F, Gruneberg U. The astrin-kinastrin/SKAP complex localizes to microtubule plus ends and facilitates chromosome alignment. J Cell Biol. 2011;192:959-68 pubmed publisher
    ..Here we describe an astrin complex containing kinastrin/SKAP, a novel kinetochore and mitotic spindle protein, and three minor interaction partners: dynein light chain, ..
  3. Huang Y, Wang W, Yao P, Wang X, Liu X, Zhuang X, et al. CENP-E kinesin interacts with SKAP protein to orchestrate accurate chromosome segregation in mitosis. J Biol Chem. 2012;287:1500-9 pubmed publisher
    ..Here, we identify a novel interaction between CENP-E and SKAP that functions synergistically in governing dynamic kinetochore-microtubule interactions...
  4. Liu Y, Xu S, Zhang C, Zhu X, Hammad M, Zhang X, et al. Hydroxysteroid dehydrogenase family proteins on lipid droplets through bacteria, C. elegans, and mammals. Biochim Biophys Acta Mol Cell Biol Lipids. 2018;1863:881-894 pubmed publisher
    ..elegans, and 17?-HSD11 in human cells. In C...
  5. Boullu Ciocca S, Tassistro V, Dutour A, Grino M. Pioglitazone in adult rats reverses immediate postnatal overfeeding-induced metabolic, hormonal, and inflammatory alterations. Endocrine. 2015;50:608-19 pubmed publisher
    ..alterations (increased fasting insulinemia and free fatty acids) and mesenteric overexpression of GR, 11β-HSD11, CD 68, and proinflammatory cytokines mRNAs, including plasminogen-activator inhibitor type 1...
  6. LEE C, Bhaduri A, Mah A, Johnson W, Ungewickell A, Aros C, et al. Recurrent point mutations in the kinetochore gene KNSTRN in cutaneous squamous cell carcinoma. Nat Genet. 2014;46:1060-2 pubmed publisher
    Here we report the discovery of recurrent mutations concentrated at an ultraviolet signature hotspot in KNSTRN, which encodes a kinetochore protein, in 19% of cutaneous squamous cell carcinomas (SCCs)...
  7. Lee J, Kim M, Yoo N, Lee S. Absence of KNSTRN Mutation, a Cutaneous Squamous Carcinoma-Specific Mutation, in Other Solid Tumors and Leukemias. Pathol Oncol Res. 2016;22:227-8 pubmed publisher
  8. Turpaev K, Bouton C, Diet A, Glatigny A, Drapier J. Analysis of differentially expressed genes in nitric oxide-exposed human monocytic cells. Free Radic Biol Med. 2005;38:1392-400 pubmed
    ..PTIO-mediated increase in nitrosating species remarkably enhanced *NO-dependent induction of IL-8, p21/Cip1, and MKP-1 and built a specific gene expression profile. ..
  9. Gironella M, Malicet C, Cano C, Sandi M, Hamidi T, Tauil R, et al. p8/nupr1 regulates DNA-repair activity after double-strand gamma irradiation-induced DNA damage. J Cell Physiol. 2009;221:594-602 pubmed publisher
    ..MSL1-dependent HAT activity, which is negatively regulated by the stress protein p8, induces chromatin remodeling and relaxation allowing access to DNA of the repair machinery. ..

More Information


  1. Wang X, Zhuang X, Cao D, Chu Y, Yao P, Liu W, et al. Mitotic regulator SKAP forms a link between kinetochore core complex KMN and dynamic spindle microtubules. J Biol Chem. 2012;287:39380-90 pubmed publisher
    ..Our recent study shows that mitotic motor CENP-E cooperates with SKAP to orchestrate an accurate chromosome movement in mitosis...
  2. Lu S, Wang R, Cai C, Liang J, Xu L, Miao S, et al. Small kinetochore associated protein (SKAP) promotes UV-induced cell apoptosis through negatively regulating pre-mRNA processing factor 19 (Prp19). PLoS ONE. 2014;9:e92712 pubmed publisher
    ..Previous studies have shown that small kinetochore associated protein (SKAP) cooperates with kinetochore and mitotic spindle proteins to regulate mitosis...
  3. Cao D, Su Z, Wang W, Wu H, Liu X, Akram S, et al. Signaling Scaffold Protein IQGAP1 Interacts with Microtubule Plus-end Tracking Protein SKAP and Links Dynamic Microtubule Plus-end to Steer Cell Migration. J Biol Chem. 2015;290:23766-80 pubmed publisher
    ..that IQGAP1 links dynamic microtubules to steer cell migration via interacting with the plus-end tracking protein, SKAP. Biochemical characterizations revealed that IQGAP1 and SKAP form a cognate complex and that their binding ..
  4. Jaju P, Nguyen C, Mah A, Atwood S, Li J, Zia A, et al. Mutations in the Kinetochore Gene KNSTRN in Basal Cell Carcinoma. J Invest Dermatol. 2015;135:3197-3200 pubmed publisher
  5. Friese A, Faesen A, Huis In t Veld P, Fischböck J, Prumbaum D, Petrovic A, et al. Molecular requirements for the inter-subunit interaction and kinetochore recruitment of SKAP and Astrin. Nat Commun. 2016;7:11407 pubmed publisher
    ..The SKAP:Astrin heterodimer localizes to spindle microtubules and to mature microtubule-kinetochore attachments during ..
  6. Moretti R, Montagnani Marelli M, Mai S, Cariboni A, Scaltriti M, Bettuzzi S, et al. Clusterin isoforms differentially affect growth and motility of prostate cells: possible implications in prostate tumorigenesis. Cancer Res. 2007;67:10325-33 pubmed
    ..Thus, the antimotility activity of nCLU and its ability to cause dismantling of the actin cytoskeleton seem to be mediated by its binding to alpha-actinin. ..
  7. Shrestha R, Conti D, Tamura N, Braun D, Ramalingam R, Cieśliński K, et al. Aurora-B kinase pathway controls the lateral to end-on conversion of kinetochore-microtubule attachments in human cells. Nat Commun. 2017;8:150 pubmed publisher
    ..Finally, we uncover a novel role for Aurora-B regulated Astrin-SKAP complex in ensuring the correct plane of kinetochore-microtubule attachment...