KLLN

Summary

Gene Symbol: KLLN
Description: killin, p53-regulated DNA replication inhibitor
Alias: CWS4, KILLIN, killin
Species: human

Top Publications

  1. pmc Germline epigenetic regulation of KILLIN in Cowden and Cowden-like syndrome
    Kristi L Bennett
    Genomic Medicine Institute, Cleveland Clinic, 9500 Euclid Ave, Cleveland, OH 44195, USA
    JAMA 304:2724-31. 2010
  2. pmc Incidence and clinical characteristics of thyroid cancer in prospective series of individuals with Cowden and Cowden-like syndrome characterized by germline PTEN, SDH, or KLLN alterations
    Joanne Ngeow
    Genomic Medicine Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, Ohio 44195, USA
    J Clin Endocrinol Metab 96:E2063-71. 2011
  3. doi Analysis of KLLN as a high-penetrance breast cancer predisposition gene
    Ella R Thompson
    VBCRC Cancer Genetics Laboratory, Peter MacCallum Cancer Centre, Locked Bag 1, A Beckett St, East Melbourne, VIC 8006, Australia
    Breast Cancer Res Treat 134:543-7. 2012
  4. pmc Transcription factor KLLN inhibits tumor growth by AR suppression, induces apoptosis by TP53/TP73 stimulation in prostate carcinomas, and correlates with cellular differentiation
    Yu Wang
    Genomic Medicine Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA
    J Clin Endocrinol Metab 98:E586-94. 2013
  5. pmc Killin is a p53-regulated nuclear inhibitor of DNA synthesis
    Yong Jig Cho
    Department of Cancer Biology, Vanderbilt Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Proc Natl Acad Sci U S A 105:5396-401. 2008
  6. doi S-phase-coupled apoptosis in tumor suppression
    Yong Jig Cho
    Department of Cancer Biology, Vanderbilt Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Cell Mol Life Sci 68:1883-96. 2011
  7. pmc Germline and somatic DNA methylation and epigenetic regulation of KILLIN in renal cell carcinoma
    Kristi L Bennett
    Genomic Medicine Institute, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA
    Genes Chromosomes Cancer 50:654-61. 2011

Scientific Experts

  • Yong Jig Cho
  • GARY JAY BRENNER
  • Charis Eng
  • Kristi L Bennett
  • Yu Wang
  • Ella R Thompson
  • Joanne Ngeow
  • Jessica Mester
  • Donna M Peehl
  • Xin He
  • Deepa Radhakrishnan
  • Gillian Mitchell
  • Kylie L Gorringe
  • David Y H Choong
  • Diana M Eccles
  • Ian G Campbell
  • Hartmut P H Neumann
  • Shireen Ganapathi
  • Lisa A Rybicki
  • Brian Rini
  • Ming Zhou
  • Rebecca Campbell
  • Mira Milas
  • Ram Ganapathi
  • Ying Ni

Detail Information

Publications7

  1. pmc Germline epigenetic regulation of KILLIN in Cowden and Cowden-like syndrome
    Kristi L Bennett
    Genomic Medicine Institute, Cleveland Clinic, 9500 Euclid Ave, Cleveland, OH 44195, USA
    JAMA 304:2724-31. 2010
    ..mechanisms of loss of function such as hypermethylation, which should result in underexpression of PTEN or of KILLIN, a novel tumor suppressor transcribed in the opposite direction, may account for the remainder of Cowden syndrome ..
  2. pmc Incidence and clinical characteristics of thyroid cancer in prospective series of individuals with Cowden and Cowden-like syndrome characterized by germline PTEN, SDH, or KLLN alterations
    Joanne Ngeow
    Genomic Medicine Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, Ohio 44195, USA
    J Clin Endocrinol Metab 96:E2063-71. 2011
    ..Thyroid cancer is believed to be an important component of Cowden syndrome (CS). Germline PTEN and SDHx mutations and KLLN epimutation cause CS and CS-like phenotypes...
  3. doi Analysis of KLLN as a high-penetrance breast cancer predisposition gene
    Ella R Thompson
    VBCRC Cancer Genetics Laboratory, Peter MacCallum Cancer Centre, Locked Bag 1, A Beckett St, East Melbourne, VIC 8006, Australia
    Breast Cancer Res Treat 134:543-7. 2012
    b>KLLN is a p53 target gene with DNA binding function and represents a highly plausible candidate breast cancer predisposition gene...
  4. pmc Transcription factor KLLN inhibits tumor growth by AR suppression, induces apoptosis by TP53/TP73 stimulation in prostate carcinomas, and correlates with cellular differentiation
    Yu Wang
    Genomic Medicine Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA
    J Clin Endocrinol Metab 98:E586-94. 2013
    b>KLLN is a newly identified gene with unknown function and shares a bidirectional promoter with PTEN.
  5. pmc Killin is a p53-regulated nuclear inhibitor of DNA synthesis
    Yong Jig Cho
    Department of Cancer Biology, Vanderbilt Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Proc Natl Acad Sci U S A 105:5396-401. 2008
    ..Here, we report the discovery of a p53 target gene dubbed killin, which lies in close proximity to pten on human chromosome 10 and encodes a 20-kDa nuclear protein...
  6. doi S-phase-coupled apoptosis in tumor suppression
    Yong Jig Cho
    Department of Cancer Biology, Vanderbilt Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Cell Mol Life Sci 68:1883-96. 2011
    ..This review focuses on accumulating evidence, with the emphasis on recently discovered Killin, that S-phase checkpoint control is crucial for a mammalian cell to make a life and death decision in order to ..
  7. pmc Germline and somatic DNA methylation and epigenetic regulation of KILLIN in renal cell carcinoma
    Kristi L Bennett
    Genomic Medicine Institute, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA
    Genes Chromosomes Cancer 50:654-61. 2011
    We recently identified germline methylation of KILLIN, a novel p53-regulated tumor suppressor proximal to PTEN, in >1/3 Cowden or Cowden syndrome-like (CS/CSL) individuals who are PTEN mutation negative...