KLK6

Summary

Gene Symbol: KLK6
Description: kallikrein related peptidase 6
Alias: Bssp, Klk7, PRSS18, PRSS9, SP59, hK6, kallikrein-6, kallikrein 6, neurosin, protease M, serine protease 18, serine protease 9, zyme
Species: human
Products:     KLK6

Top Publications

  1. Talieri M, Zoma M, Devetzi M, Scorilas A, Ardavanis A. Kallikrein-related peptidase 6 (KLK6)gene expression in intracranial tumors. Tumour Biol. 2012;33:1375-83 pubmed publisher
    ..Kallikrein-related peptidase 6 (KLK6) has the highest expression in normal brain among other tissues...
  2. Pampalakis G, Kurlender L, Diamandis E, Sotiropoulou G. Cloning and characterization of novel isoforms of the human kallikrein 6 gene. Biochem Biophys Res Commun. 2004;320:54-61 pubmed
    Human kallikrein 6 (protease M/zyme/neurosin) was originally identified based on its aberrant expression in tumor cells and is considered a biomarker for ovarian cancer...
  3. Nagahara H, Mimori K, Utsunomiya T, Barnard G, Ohira M, Hirakawa K, et al. Clinicopathologic and biological significance of kallikrein 6 overexpression in human gastric cancer. Clin Cancer Res. 2005;11:6800-6 pubmed
    ..Herein, we investigated the clinicopathologic and biological significance of KLK6 gene expression in human gastric cancer...
  4. Henkhaus R, Gerner E, Ignatenko N. Kallikrein 6 is a mediator of K-RAS-dependent migration of colon carcinoma cells. Biol Chem. 2008;389:757-64 pubmed publisher
    b>Kallikrein 6 (KLK6) is a trypsin-like serine peptidase whose relevance in various types of cancers is currently being explored...
  5. Scarisbrick I, Blaber S, Lucchinetti C, Genain C, Blaber M, Rodriguez M. Activity of a newly identified serine protease in CNS demyelination. Brain. 2002;125:1283-96 pubmed
    ..These studies support the hypothesis that excess MSP, as is present in inflammatory CNS lesions, promotes demyelination. ..
  6. Zarghooni M, Soosaipillai A, Grass L, Scorilas A, Mirazimi N, Diamandis E. Decreased concentration of human kallikrein 6 in brain extracts of Alzheimer's disease patients. Clin Biochem. 2002;35:225-31 pubmed
    The human kallikrein 6 gene (KLK6) encodes for a secreted serine protease, hK6, which is highly expressed in brain. Previous reports have associated hK6 with the pathogenesis of Alzheimer's disease...
  7. Rezze G, Fregnani J, Duprat J, Landman G. Cell adhesion and communication proteins are differentially expressed in melanoma progression model. Hum Pathol. 2011;42:409-18 pubmed publisher
    ..expression of the adhesion and communication molecules connexin 43, desmocollin 3, cytokeratin 5, kallikrein 6, and kallikrein 7 in a melanoma progression model...
  8. Oikonomopoulou K, Hansen K, Saifeddine M, Tea I, Blaber M, Blaber S, et al. Proteinase-activated receptors, targets for kallikrein signaling. J Biol Chem. 2006;281:32095-112 pubmed
    ..Our data indicate that in physiological settings, hKs may represent important endogenous regulators of the PARs and that different hKs can have differential actions on PAR(1), PAR(2), and PAR(4). ..
  9. White N, Mathews M, Yousef G, Prizada A, Popadiuk C, Doré J. KLK6 and KLK13 predict tumor recurrence in epithelial ovarian carcinoma. Br J Cancer. 2009;101:1107-13 pubmed publisher
    ..The aim of this study was to determine the prognostic significance of kallikrein-related peptidase 6 (KLK6) and kallikrein-related peptidase 13 (KLK13) in epithelial ovarian cancer by quantifying gene expression levels ..

More Information

Publications75

  1. Pampalakis G, Prosnikli E, Agalioti T, Vlahou A, Zoumpourlis V, Sotiropoulou G. A tumor-protective role for human kallikrein-related peptidase 6 in breast cancer mediated by inhibition of epithelial-to-mesenchymal transition. Cancer Res. 2009;69:3779-87 pubmed publisher
    Human kallikrein-related peptidase 6 (KLK6) was cloned as a putative class II tumor suppressor based on its inactivated expression in metastatic breast cancer...
  2. Ashby E, Kehoe P, Love S. Kallikrein-related peptidase 6 in Alzheimer's disease and vascular dementia. Brain Res. 2010;1363:1-10 pubmed publisher
    Human kallikrein-related peptidase 6 (KLK6) is highly expressed in the central nervous system...
  3. Petraki C, Karavana V, Skoufogiannis P, Little S, Howarth D, Yousef G, et al. The spectrum of human kallikrein 6 (zyme/protease M/neurosin) expression in human tissues as assessed by immunohistochemistry. J Histochem Cytochem. 2001;49:1431-41 pubmed
    The KLK6 gene is a new member of the human kallikrein gene family and encodes for a secreted protease, human kallikrein 6 (hK6; also known as zyme/protease M/neurosin)...
  4. Bayani J, Diamandis E. The physiology and pathobiology of human kallikrein-related peptidase 6 (KLK6). Clin Chem Lab Med. 2011;50:211-33 pubmed publisher
    The human kallikrein-related peptidase 6 (KLK6) gene belongs to the 15-member kallikrein (KLK) gene family mapping to chromosome 19q13.3-13.4...
  5. Kountourakis P, Psyrri A, Scorilas A, Camp R, Markakis S, Kowalski D, et al. Prognostic value of kallikrein-related peptidase 6 protein expression levels in advanced ovarian cancer evaluated by automated quantitative analysis (AQUA). Cancer Sci. 2008;99:2224-9 pubmed publisher
    ..In the present study, we sought to determine the prognostic value of kallikrein-related peptidase 6 (KLK6) in ovarian cancer using a novel method of compartmentalized in situ protein analysis...
  6. Kim J, Song E, Chung K, Kang M, Kim J, Kim S, et al. Up-regulation and clinical significance of serine protease kallikrein 6 in colon cancer. Cancer. 2011;117:2608-19 pubmed publisher
    Kallikrein-related peptidase 6 (KLK6) encodes a trypsin-like serine protease that is up-regulated in several cancers, although the putative functions of KLK6 in cancer have not been elucidated...
  7. Angelo P, Lima A, Alves F, Blaber S, Scarisbrick I, Blaber M, et al. Substrate specificity of human kallikrein 6: salt and glycosaminoglycan activation effects. J Biol Chem. 2006;281:3116-26 pubmed
    Human kallikrein 6 (hK6) is abundantly expressed in the central nervous system and is implicated in demyelinating disease...
  8. Petraki C, Dubinski W, Scorilas A, Saleh C, Pasic M, Komborozos V, et al. Evaluation and prognostic significance of human tissue kallikrein-related peptidase 6 (KLK6) in colorectal cancer. Pathol Res Pract. 2012;208:104-8 pubmed publisher
    ..The aim of this study was to investigate the expression of human tissue kallikrein-related peptidase 6 (KLK6) by immunohistochemistry in CRC to correlate this expression with various histopathological and clinical variables, ..
  9. Santin A, Diamandis E, Bellone S, Soosaipillai A, Cane S, Palmieri M, et al. Human kallikrein 6: a new potential serum biomarker for uterine serous papillary cancer. Clin Cancer Res. 2005;11:3320-5 pubmed
    ..The discovery of novel biomarkers might greatly contribute to improve clinical management and outcomes in uterine serous papillary carcinoma (USPC), a highly aggressive variant of endometrial cancer...
  10. Magklara A, Mellati A, Wasney G, Little S, Sotiropoulou G, Becker G, et al. Characterization of the enzymatic activity of human kallikrein 6: Autoactivation, substrate specificity, and regulation by inhibitors. Biochem Biophys Res Commun. 2003;307:948-55 pubmed
    Human kallikrein 6 (hK6) is a trypsin-like serine protease, member of the human kallikrein gene family. Studies suggested a potential involvement of hK6 in the development and progression of Alzheimer's disease...
  11. Bayes A, Tsetsenis T, Ventura S, Vendrell J, Aviles F, Sotiropoulou G. Human kallikrein 6 activity is regulated via an autoproteolytic mechanism of activation/inactivation. Biol Chem. 2004;385:517-24 pubmed
    Human kallikrein 6 (protease M/zyme/neurosin) is a serine protease that has been suggested to be a serum biomarker for ovarian cancer and may also be involved in pathologies of the CNS...
  12. Tatebe H, Watanabe Y, Kasai T, Mizuno T, Nakagawa M, Tanaka M, et al. Extracellular neurosin degrades ?-synuclein in cultured cells. Neurosci Res. 2010;67:341-6 pubmed publisher
    Neurosin, also called kallikrein 6, is a trypsin-like serine protease predominantly expressed in the central nervous system...
  13. Scarisbrick I, Epstein B, Cloud B, Yoon H, Wu J, Renner D, et al. Functional role of kallikrein 6 in regulating immune cell survival. PLoS ONE. 2011;6:e18376 pubmed publisher
    b>Kallikrein 6 (KLK6) is a newly identified member of the kallikrein family of secreted serine proteases that prior studies indicate is elevated at sites of central nervous system (CNS) inflammation and which shows regulated expression with ..
  14. Seiz L, Dorn J, Kotzsch M, Walch A, Grebenchtchikov N, Gkazepis A, et al. Stromal cell-associated expression of kallikrein-related peptidase 6 (KLK6) indicates poor prognosis of ovarian cancer patients. Biol Chem. 2012;393:391-401 pubmed publisher
    Several members of the human kallikrein-related peptidase family, including KLK6, are up-regulated in ovarian cancer...
  15. Kim J, Kim J, Yoon H, Kang M, Kim J, Lee Y, et al. Upregulation and secretion of kallikrein-related peptidase 6 (KLK6) in gastric cancer. Tumour Biol. 2012;33:731-8 pubmed publisher
    b>KLK6 encoding kallikrein-related peptidase 6, a trypsin-like serine protease, has been shown to be upregulated in several cancers, although the tumorigenic role of KLK6 has not been elucidated...
  16. Christodoulou S, Alexopoulou D, Kontos C, Scorilas A, Papadopoulos I. Kallikrein-related peptidase-6 (KLK6) mRNA expression is an independent prognostic tissue biomarker of poor disease-free and overall survival in colorectal adenocarcinoma. Tumour Biol. 2014;35:4673-85 pubmed publisher
    ..Moreover, the oncogenic role of kallikrein-related peptidase-6 (KLK6) in colorectal cancer has been well documented so far...
  17. Yamashiro K, Tsuruoka N, Kodama S, Tsujimoto M, Yamamura Y, Tanaka T, et al. Molecular cloning of a novel trypsin-like serine protease (neurosin) preferentially expressed in brain. Biochim Biophys Acta. 1997;1350:11-4 pubmed
    A cDNA encoding a precursor for a novel serine protease (neurosin) was cloned from a cDNA library prepared from a human colon adenocarcinoma cell line, COLO 201...
  18. Little S, Dixon E, Norris F, Buckley W, Becker G, Johnson M, et al. Zyme, a novel and potentially amyloidogenic enzyme cDNA isolated from Alzheimer's disease brain. J Biol Chem. 1997;272:25135-42 pubmed
    ..A cDNA clone was identified as one out of one million that encodes Zyme, a serine protease...
  19. Yousef G, Luo L, Scherer S, Sotiropoulou G, Diamandis E. Molecular characterization of zyme/protease M/neurosin (PRSS9), a hormonally regulated kallikrein-like serine protease. Genomics. 1999;62:251-9 pubmed
    The cDNA for the zyme/protease M/neurosin gene (HGMW-approved symbol PRSS9) has recently been identified. Zyme appears to play a role in Alzheimer disease as well as in breast cancer...
  20. Ogawa K, Utsunomiya T, Mimori K, Tanaka F, Inoue H, Nagahara H, et al. Clinical significance of human kallikrein gene 6 messenger RNA expression in colorectal cancer. Clin Cancer Res. 2005;11:2889-93 pubmed
    Human kallikrein gene 6 (KLK6) is a member of the human kallikrein gene family, and recent studies have found that many kallikreins have altered expression patterns in various malignancies...
  21. Bernett M, Blaber S, Scarisbrick I, Dhanarajan P, Thompson S, Blaber M. Crystal structure and biochemical characterization of human kallikrein 6 reveals that a trypsin-like kallikrein is expressed in the central nervous system. J Biol Chem. 2002;277:24562-70 pubmed
    ..Human kallikrein 6 has been proposed as the homologue to rat myelencephalon-specific protease, an arginine-specific degradative-..
  22. Christophi G, Isackson P, Blaber S, Blaber M, Rodriguez M, Scarisbrick I. Distinct promoters regulate tissue-specific and differential expression of kallikrein 6 in CNS demyelinating disease. J Neurochem. 2004;91:1439-49 pubmed
    b>Kallikrein 6 is a serine protease expressed abundantly in normal adult human and rodent CNS, and therein is regulated by injury...
  23. Ghosh M, Grass L, Soosaipillai A, Sotiropoulou G, Diamandis E. Human kallikrein 6 degrades extracellular matrix proteins and may enhance the metastatic potential of tumour cells. Tumour Biol. 2004;25:193-9 pubmed
    Human kallikrein 6 (hK6), a trypsin-like serine protease, is a newly identified member of the kallikrein gene family. Its involvement in inflammatory CNS lesions and in demyelination has been reported...
  24. Iwata A, Maruyama M, Akagi T, Hashikawa T, Kanazawa I, Tsuji S, et al. Alpha-synuclein degradation by serine protease neurosin: implication for pathogenesis of synucleinopathies. Hum Mol Genet. 2003;12:2625-35 pubmed
    ..In view of proteolytic degradation, we have found that the serine protease neurosin (kallikrein-6) degrades alpha-synuclein and co-localizes with pathological inclusions such as Lewy bodies and ..
  25. Mitsui S, Okui A, Uemura H, Mizuno T, Yamada T, Yamamura Y, et al. Decreased cerebrospinal fluid levels of neurosin (KLK6), an aging-related protease, as a possible new risk factor for Alzheimer's disease. Ann N Y Acad Sci. 2002;977:216-23 pubmed
    b>Neurosin is a kallikrein-like serine protease expressed preferentially in the human brain...
  26. Ruckert F, Hennig M, Petraki C, Wehrum D, Distler M, Denz A, et al. Co-expression of KLK6 and KLK10 as prognostic factors for survival in pancreatic ductal adenocarcinoma. Br J Cancer. 2008;99:1484-92 pubmed publisher
    ..Previous studies suggested an upregulation of KLK10 and KLK6 in pancreatic ductal adenocarcinoma (PDAC)...
  27. Nathalie H, Chris P, Serge G, Catherine C, Benjamin B, Claire B, et al. High kallikrein-related peptidase 6 in non-small cell lung cancer cells: an indicator of tumour proliferation and poor prognosis. J Cell Mol Med. 2009;13:4014-22 pubmed publisher
    ..We have analysed the production of KLK6 in normal lung and tumour tissues from patients with non-small cell lung cancer (NSCLC)...
  28. Hoffman B, Katsaros D, Scorilas A, Diamandis P, Fracchioli S, Rigault de la Longrais I, et al. Immunofluorometric quantitation and histochemical localisation of kallikrein 6 protein in ovarian cancer tissue: a new independent unfavourable prognostic biomarker. Br J Cancer. 2002;87:763-71 pubmed
    Human kallikrein 6 protein is a newly discovered human kallikrein...
  29. Koh S, Razvi K, Chan Y, Narasimhan K, Ilancheran A, Low J, et al. The association with age, human tissue kallikreins 6 and 10 and hemostatic markers for survival outcome from epithelial ovarian cancer. Arch Gynecol Obstet. 2011;284:183-90 pubmed publisher
    To assess known cancer biomarkers CA-125, human tissue kallikreins KLK6 and KLK10, hemostatic markers and age with 5-year survival outcome from epithelial ovarian cancer...
  30. Anisowicz A, Sotiropoulou G, Stenman G, Mok S, Sager R. A novel protease homolog differentially expressed in breast and ovarian cancer. Mol Med. 1996;2:624-36 pubmed
    ..display (DD), we discovered a new member of the serine protease family of protein-cleaving enzymes, named protease M. The gene is most closely related by sequence to the kallikreins, to prostate-specific antigen (PSA), and to ..
  31. Yousef G, Kishi T, Diamandis E. Role of kallikrein enzymes in the central nervous system. Clin Chim Acta. 2003;329:1-8 pubmed
    ..KLK6 (zyme/protease M/neurosin) seems to be down regulated in serum and tissues of Alzheimer's disease patients and may be involved in ..
  32. Ahmed N, Dorn J, Napieralski R, Drecoll E, Kotzsch M, Goettig P, et al. Clinical relevance of kallikrein-related peptidase 6 (KLK6) and 8 (KLK8) mRNA expression in advanced serous ovarian cancer. Biol Chem. 2016;397:1265-1276 pubmed publisher
    ..In the present study, we assessed the mRNA expression levels of KLK6 and KLK8 by quantitative PCR in 100 patients with advanced serous ovarian cancer FIGO stage III/IV...
  33. Bayani J, Kuzmanov U, Saraon P, Fung W, Soosaipillai A, Squire J, et al. Copy number and expression alterations of miRNAs in the ovarian cancer cell line OVCAR-3: impact on kallikrein 6 protein expression. Clin Chem. 2013;59:296-305 pubmed publisher
    Kallikrein-related peptidase 6 (KLK6), a member of the serine protease family of kallikrein (KLK) genes, is dysregulated in ovarian carcinomas (OCa) and its overexpression is associated with poor prognosis...
  34. Tamir A, Jag U, Sarojini S, Schindewolf C, Tanaka T, Gharbaran R, et al. Kallikrein family proteases KLK6 and KLK7 are potential early detection and diagnostic biomarkers for serous and papillary serous ovarian cancer subtypes. J Ovarian Res. 2014;7:109 pubmed publisher
    ..Two kallikrein (KLK) serine protease family members (KLK6 and KLK7) were found to be significantly overexpressed relative to normal controls in most of the ovarian cancer ..
  35. Ripert G, Racedo S, Elie A, Jacquot C, Bressollier P, Urdaci M. Secreted Compounds of the Probiotic Bacillus clausii Strain O/C Inhibit the Cytotoxic Effects Induced by Clostridium difficile and Bacillus cereus Toxins. Antimicrob Agents Chemother. 2016;60:3445-54 pubmed publisher
    ..difficile and B. cereus strains. This extracellular compound could be responsible, at least in part, for the protective effects observed for this human probiotic in antibiotic-associated diarrhea. ..
  36. Gan L, Lee I, Smith R, Argonza Barrett R, Lei H, McCuaig J, et al. Sequencing and expression analysis of the serine protease gene cluster located in chromosome 19q13 region. Gene. 2000;257:119-30 pubmed
    ..The proteases, excluding the kallikrein genes, share approximately 40% of their sequences suggesting that the serine protease gene cluster on chromosome 19q13 arose from ancient gene duplications. ..
  37. Cheong K, Lee T, Lee A. Complementary effect of hydroquinone and retinoic acid on corneocyte desquamation with their combination use. J Dermatol Sci. 2017;87:192-200 pubmed publisher
    ..Expression levels of corneodesmosin (CDSN), desmocollin1 (DSC1), kallikrein5 (KLK5), KLK7, and SPINK5/LEKTI, and proteolysis activity against extracted human skin epidermal protein were determined using ..
  38. Ulbricht D, Pippel J, Schultz S, Meier R, Sträter N, Heiker J. A unique serpin P1' glutamate and a conserved β-sheet C arginine are key residues for activity, protease recognition and stability of serpinA12 (vaspin). Biochem J. 2015;470:357-67 pubmed publisher
    ..b>KLK7 (kallikrein 7) is the only known protease target of vaspin to date and is inhibited with a moderate inhibition rate...
  39. Yu W, Field C, Wu J. Purification and identification of anti-inflammatory peptides from spent hen muscle proteins hydrolysate. Food Chem. 2018;253:101-107 pubmed publisher
    ..This study explored the use of spent hens as a source of bioactive peptides. Spent hen hydrolysates prepared by Protease M or Protex 50FP exhibited interleukin (IL)-6 inhibitory activity in endotoxin-activated macrophage-like U937 ..
  40. Williams M, Nakatsuji T, Sanford J, Vrbanac A, Gallo R. Staphylococcus aureus Induces Increased Serine Protease Activity in Keratinocytes. J Invest Dermatol. 2017;137:377-384 pubmed publisher
    ..This increased protease activity coincided with increased expression of mRNA for kallikreins (KLKs), with KLK6, 13, and 14 showing the greatest induction after exposure to S. aureus...
  41. Klein R, Hallden C, Cronin A, Ploner A, Wiklund F, Bjartell A, et al. Blood biomarker levels to aid discovery of cancer-related single-nucleotide polymorphisms: kallikreins and prostate cancer. Cancer Prev Res (Phila). 2010;3:611-9 pubmed publisher
    ..874 versus 0.866), providing proof in principle to clinical application for our findings. ..
  42. Miners J, Renfrew R, Swirski M, Love S. Accumulation of α-synuclein in dementia with Lewy bodies is associated with decline in the α-synuclein-degrading enzymes kallikrein-6 and calpain-1. Acta Neuropathol Commun. 2014;2:164 pubmed publisher
    ..Our results indicate that reductions in kallikrein-6 and calpain-1 may contribute to the accumulation of α-synuclein in DLB. ..
  43. Singh H, Rajeswari M. Role of long purine stretches in controlling the expression of genes associated with neurological disorders. Gene. 2015;572:175-83 pubmed publisher
    ..four PR-genes in signaling pathways whose dysregulation is correlated directly with pathogenesis: GRK5 and KLK6 in Alzheimer's disease; FGF14 in craniosynostosis, mental retardation and FLT1 in neuroferritinopathy...
  44. Radulovic M, Yoon H, Wu J, Mustafa K, Fehlings M, Scarisbrick I. Genetic targeting of protease activated receptor 2 reduces inflammatory astrogliosis and improves recovery of function after spinal cord injury. Neurobiol Dis. 2015;83:75-89 pubmed publisher
    ..was further investigated in primary astrocytes to reveal that the SCI-related serine protease, neurosin (kallikrein 6) promotes IL-6 secretion in a PAR2 and STAT3-dependent manner...
  45. Yoon H, Scarisbrick I. Kallikrein-related peptidase 6 exacerbates disease in an autoimmune model of multiple sclerosis. Biol Chem. 2016;397:1277-1286 pubmed publisher
    Kallikrein-related peptidase 6 (Klk6) is elevated in the serum of multiple sclerosis (MS) patients and is hypothesized to participate in inflammatory and neuropathogenic aspects of the disease...
  46. Sardana G, Diamandis E. The kallikrein family of proteins as urinary biomarkers for the detection of prostate cancer. Clin Biochem. 2009;42:1483-6 pubmed publisher
    ..We were unable to distinguish men with and without prostate cancer using multiple kallikreins as urinary biomarkers. These results highlight the difficulties in diagnosing prostate cancer via urine testing for soluble biomarkers. ..
  47. Teo C, Casey P, Rasheed S. The GNA13-RhoA signaling axis suppresses expression of tumor protective Kallikreins. Cell Signal. 2016;28:1479-88 pubmed publisher
    ..down-regulation of several members of the Kallikrein-related peptidases (KLK) gene family, namely KLK5, KLK6, KLK7, KLK8 and KLK10, in MCF-10a lines with enhanced GNA13 protein expression...
  48. Li H, Hwang B, Laxmikanthan G, Blaber S, Blaber M, Golubkov P, et al. Substrate specificity of human kallikreins 1 and 6 determined by phage display. Protein Sci. 2008;17:664-72 pubmed publisher
    ..b>KLK6 is overexpressed in breast and ovarian cancer tissues and has been shown to cleave peptide derived from human ..
  49. Briollais L, Ozcelik H, Xu J, Kwiatkowski M, Lalonde E, Sendorek D, et al. Germline Mutations in the Kallikrein 6 Region and Predisposition for Aggressive Prostate Cancer. J Natl Cancer Inst. 2017;109: pubmed publisher
    ..15, 95% CI = 1.57 to 6.34, P = .001). Our fine-mapping study has identified novel loci in the KLK 6 region strongly associated with aggressive PCa. ..
  50. Sinharay S, Randtke E, Howison C, Ignatenko N, Pagel M. Detection of Enzyme Activity and Inhibition during Studies in Solution, In Vitro and In Vivo with CatalyCEST MRI. Mol Imaging Biol. 2018;20:240-248 pubmed publisher
    ..We tested the ability of this agent to detect the activity of kallikrein 6 (KLK6) in biochemical solutions, in vitro and in vivo, with and without a KLK6 inhibitor...
  51. Kempuraj D, Selvakumar G, Zaheer S, Thangavel R, Ahmed M, Raikwar S, et al. Cross-Talk between Glia, Neurons and Mast Cells in Neuroinflammation Associated with Parkinson's Disease. J Neuroimmune Pharmacol. 2018;13:100-112 pubmed publisher
    ..mediators mouse mast cell protease-6 (MMCP-6), MMCP-7 or tryptase/brain-specific serine protease-4 (tryptase/BSSP-4)...
  52. Zhang Y, Zhang Z, Yang L, Xu B, Li W, Tang P, et al. Identification of human tissue kallikrein 6 as a potential marker of laryngeal cancer based on the relevant secretory/releasing protein database. Dis Markers. 2014;2014:594093 pubmed publisher
    ..Of these, human tissue kallikrein 6 (KLK6) was verified...
  53. Michel N, Heuzé Vourc h N, Lavergne E, Parent C, Jourdan M, Vallet A, et al. Growth and survival of lung cancer cells: regulation by kallikrein-related peptidase 6 via activation of proteinase-activated receptor 2 and the epidermal growth factor receptor. Biol Chem. 2014;395:1015-25 pubmed publisher
    The dysregulated expression of kallikrein-related peptidase 6 (KLK6) is involved in non-small cancer (NSCLC) cell growth. However, the mechanism that sustains KLK6 signaling remains unknown...
  54. Hu C, Zhang F, Chen Y, Sun X, Zheng J. [Correlation of hK6 expression with clinicopathological features and prognosis in epithelial ovarian cancer]. Zhonghua Zhong Liu Za Zhi. 2009;31:520-3 pubmed
    To approach the relationship between the expression of hK6 in ovarian neoplasm and clinicopathological variables and prognosis in ovarian cancer patients for finding a new tumor marker of the ovarian cancer...
  55. Srivastava D, Razzaghi M, Henzl M, Dey M. Structural Investigation of a Dimeric Variant of Pyruvate Kinase M2. Biochemistry. 2017;: pubmed publisher
    ..FBP stabilizes the tetrameric form of the en-zyme. In its absence, the PKM2 tetramers dissociate, yield-ing a dimer-monomer mixture having lower enzymatic ac-tivity...
  56. Siau K, Yew A, Ishaq S, Jewes S, S S, Brookes M, et al. Colonoscopy conversion after flexible sigmoidoscopy screening: results from the uk bowel scope screening programme. Colorectal Dis. 2017;: pubmed publisher
    In the UK Bowel Scope screening programme (BSSP), patients progress to colonoscopy based on high-risk features on flexible sigmoidoscopy (FS).
  57. Krenzer S, Peterziel H, Mauch C, Blaber S, Blaber M, Angel P, et al. Expression and function of the kallikrein-related peptidase 6 in the human melanoma microenvironment. J Invest Dermatol. 2011;131:2281-8 pubmed publisher
    ..We investigated the expression pattern of the kallikrein-related peptidase 6 (KLK6) in human melanoma tissue sections throughout tumor development...
  58. . Proceedings of the 1st International Symposium on Kallikreins, Lausanne, Switzerland, September 1-3 , 2005. Biol Chem. 2006;387:635-824 pubmed
  59. Pampalakis G, Sotiropoulou G. Multiple mechanisms underlie the aberrant expression of the human kallikrein 6 gene in breast cancer. Biol Chem. 2006;387:773-82 pubmed
    Human kallikrein 6 (KLK6) was identified based on its transient upregulation in a primary breast tumor and its subsequent silencing in a metastatic tumor from the same patient...
  60. Drucker K, Gianinni C, Decker P, Diamandis E, Scarisbrick I. Prognostic significance of multiple kallikreins in high-grade astrocytoma. BMC Cancer. 2015;15:565 pubmed publisher
    ..We previously demonstrated that kallikrein 6 is expressed at higher levels in grade IV compared to grade III astrocytoma and is associated with reduced ..
  61. Kuzmanov U, Jiang N, Smith C, Soosaipillai A, Diamandis E. Differential N-glycosylation of kallikrein 6 derived from ovarian cancer cells or the central nervous system. Mol Cell Proteomics. 2009;8:791-8 pubmed publisher
    ..Perturbed glycosylation is one of the hallmarks of this malignancy. Kallikrein 6 (KLK6) elevation in serum is a diagnostic and prognostic indicator in ovarian cancer...
  62. Schrader C, Kolb M, Zaoui K, Flechtenmacher C, Grabe N, Weber K, et al. Kallikrein-related peptidase 6 regulates epithelial-to-mesenchymal transition and serves as prognostic biomarker for head and neck squamous cell carcinoma patients. Mol Cancer. 2015;14:107 pubmed publisher
    Dysregulated expression of Kallikrein-related peptidase 6 (KLK6) is a common feature for many human malignancies and numerous studies evaluated KLK6 as a promising biomarker for early diagnosis or unfavorable prognosis...
  63. Laouirem S, Le Faouder J, Alexandrov T, Mestivier D, Léger T, Baudin X, et al. Progression from cirrhosis to cancer is associated with early ubiquitin post-translational modifications: identification of new biomarkers of cirrhosis at risk of malignancy. J Pathol. 2014;234:452-63 pubmed publisher
    ..We showed that kallikrein-related peptidase 6 (KLK6) catalysed the production of Ubi(1-74) from monomeric ubiquitin...
  64. Spencer B, Michael S, Shen J, Kosberg K, Rockenstein E, Patrick C, et al. Lentivirus mediated delivery of neurosin promotes clearance of wild-type ?-synuclein and reduces the pathology in an ?-synuclein model of LBD. Mol Ther. 2013;21:31-41 pubmed publisher
    b>Neurosin is a predominant serine protease in the central nervous system (CNS) and has been shown to play a role in the clearance of ?-synuclein (?-syn) which is centrally involved in the pathogenesis of Parkinson's disease (PD) and ..
  65. Rovelet Lecrux A, Legallic S, Wallon D, Flaman J, Martinaud O, Bombois S, et al. A genome-wide study reveals rare CNVs exclusive to extreme phenotypes of Alzheimer disease. Eur J Hum Genet. 2012;20:613-7 pubmed publisher
    ..Strikingly, 4 out of 7 rearrangements target genes (KLK6, SLC30A3, MEOX2, and FPR2) encoding proteins that are tightly related to amyloid-? peptide metabolism or signalling...
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