KLK5

Summary

Gene Symbol: KLK5
Description: kallikrein-related peptidase 5
Alias: KLK-L2, KLKL2, SCTE, kallikrein 5, kallikrein-5, kallikrein-like protein 2, stratum corneum tryptic enzyme
Species: human

Top Publications

  1. ncbi Human kallikrein gene 5 (KLK5) expression is an indicator of poor prognosis in ovarian cancer
    H Kim
    Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, 600 University Ave, Toronto, M5G 1X5, Canada
    Br J Cancer 84:643-50. 2001
  2. ncbi Spink5-deficient mice mimic Netherton syndrome through degradation of desmoglein 1 by epidermal protease hyperactivity
    Pascal Descargues
    INSERM U563, Paul Sabatier University, Place du Dr Baylac, 31059 Toulouse, Cedex 3, France
    Nat Genet 37:56-65. 2005
  3. ncbi Human tissue kallikreins: the cancer biomarker family
    Miltiadis Paliouras
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, ON, Canada
    Cancer Lett 249:61-79. 2007
  4. ncbi Activation of hepatocyte growth factor activator zymogen (pro-HGFA) by human kallikrein 1-related peptidases
    Shoichiro Mukai
    Section of Oncopathology and Regenerative Biology, Department of Pathology, Faculty of Medicine, University of Miyazaki, Japan
    FEBS J 275:1003-17. 2008
  5. ncbi Human tissue kallikrein expression in the stratum corneum and serum of atopic dermatitis patients
    Nahoko Komatsu
    Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, ON, Canada
    Exp Dermatol 16:513-9. 2007
  6. ncbi High-throughput screening identifies cardiac glycosides as potent inhibitors of human tissue kallikrein expression: implications for cancer therapies
    Ioannis Prassas
    Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada
    Clin Cancer Res 14:5778-84. 2008
  7. ncbi Aberrant human tissue kallikrein levels in the stratum corneum and serum of patients with psoriasis: dependence on phenotype, severity and therapy
    N Komatsu
    Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, Ontario, Canada
    Br J Dermatol 156:875-83. 2007
  8. ncbi Skin barrier disruption by sodium lauryl sulfate-exposure alters the expressions of involucrin, transglutaminase 1, profilaggrin, and kallikreins during the repair phase in human skin in vivo
    Hans Torma
    Dermatology and Venereology Section, Department of Medical Sciences, Uppsala University, Uppsala, Sweden
    J Invest Dermatol 128:1212-9. 2008
  9. ncbi Human tissue kallikreins as promiscuous modulators of homeostatic skin barrier functions
    Azza Eissa
    Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto M5G 1L5, ON, Canada
    Biol Chem 389:669-80. 2008
  10. ncbi Glutathione peroxidase 2 and aquaporin 8 as new markers for colonic inflammation in experimental colitis and inflammatory bowel diseases: an important role for H2O2?
    Anje A te Velde
    Center for Experimental and Molecular Medicine, Academic Medical Center, Amsterdam, The Netherlands
    Eur J Gastroenterol Hepatol 20:555-60. 2008

Research Grants

  1. Molecular Diagnostics for Malignant Effusion
    Ie Ming Shih; Fiscal Year: 2006
  2. NATURE OF MAMMALIAN CUTANEOUS PERMEABILITY BARRIER
    Peter Elias; Fiscal Year: 2006

Scientific Experts

Detail Information

Publications98

  1. ncbi Human kallikrein gene 5 (KLK5) expression is an indicator of poor prognosis in ovarian cancer
    H Kim
    Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, 600 University Ave, Toronto, M5G 1X5, Canada
    Br J Cancer 84:643-50. 2001
    Kallikrein gene 5 (KLK5, also known as KLK-L2), located on chromosome 19q13.4, is one of the newly identified members of the kallikrein gene family, which is a subgroup of the serine protease enzyme family...
  2. ncbi Spink5-deficient mice mimic Netherton syndrome through degradation of desmoglein 1 by epidermal protease hyperactivity
    Pascal Descargues
    INSERM U563, Paul Sabatier University, Place du Dr Baylac, 31059 Toulouse, Cedex 3, France
    Nat Genet 37:56-65. 2005
    ..abnormal desmosome cleavage in the upper granular layer through degradation of desmoglein 1 due to stratum corneum tryptic enzyme and stratum corneum chymotryptic enzyme-like hyperactivity...
  3. ncbi Human tissue kallikreins: the cancer biomarker family
    Miltiadis Paliouras
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, ON, Canada
    Cancer Lett 249:61-79. 2007
    ..Along with these kallikreins, several others have been implicated in the other cancers. For example, KLK5, 6, 7, 10, 11, and 14 are emerging biomarkers for ovarian cancer...
  4. ncbi Activation of hepatocyte growth factor activator zymogen (pro-HGFA) by human kallikrein 1-related peptidases
    Shoichiro Mukai
    Section of Oncopathology and Regenerative Biology, Department of Pathology, Faculty of Medicine, University of Miyazaki, Japan
    FEBS J 275:1003-17. 2008
    ..Among the KLKs examined (KLK2, KLK3, KLK4 and KLK5), we identified KLK4 and KLK5 as novel activators of pro-HGFA...
  5. ncbi Human tissue kallikrein expression in the stratum corneum and serum of atopic dermatitis patients
    Nahoko Komatsu
    Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, ON, Canada
    Exp Dermatol 16:513-9. 2007
    ..We report quantification by enzyme-linked immunosorbent assay (ELISA) of KLK5, KLK6, KLK7, KLK8, KLK10, KLK11, KLK13 and KLK14 in the SC and serum of atopic dermatitis (AD) patients by ELISA, ..
  6. ncbi High-throughput screening identifies cardiac glycosides as potent inhibitors of human tissue kallikrein expression: implications for cancer therapies
    Ioannis Prassas
    Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada
    Clin Cancer Res 14:5778-84. 2008
    ..Therefore, the identification of compounds that would modulate expression of KLKs might be of considerable therapeutic value...
  7. ncbi Aberrant human tissue kallikrein levels in the stratum corneum and serum of patients with psoriasis: dependence on phenotype, severity and therapy
    N Komatsu
    Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, Ontario, Canada
    Br J Dermatol 156:875-83. 2007
    ..Multiple KLKs have been quantitatively identified in normal stratum corneum (SC) and sweat as candidate desquamation-related proteases...
  8. ncbi Skin barrier disruption by sodium lauryl sulfate-exposure alters the expressions of involucrin, transglutaminase 1, profilaggrin, and kallikreins during the repair phase in human skin in vivo
    Hans Torma
    Dermatology and Venereology Section, Department of Medical Sciences, Uppsala University, Uppsala, Sweden
    J Invest Dermatol 128:1212-9. 2008
    ..Changes in protein expression of KLK-5 were also found. In conclusion, SLS-induced skin barrier defects induce altered mRNA expression of keratinocyte differentiation markers and enzymes degrading corneodesmosomes...
  9. ncbi Human tissue kallikreins as promiscuous modulators of homeostatic skin barrier functions
    Azza Eissa
    Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto M5G 1L5, ON, Canada
    Biol Chem 389:669-80. 2008
    ..Until recently, kallikrein proteolytic activity in the skin was exclusively attributed to KLK5 and KLK7...
  10. ncbi Glutathione peroxidase 2 and aquaporin 8 as new markers for colonic inflammation in experimental colitis and inflammatory bowel diseases: an important role for H2O2?
    Anje A te Velde
    Center for Experimental and Molecular Medicine, Academic Medical Center, Amsterdam, The Netherlands
    Eur J Gastroenterol Hepatol 20:555-60. 2008
    ..We looked for overlapping gene expression profiles in three different mouse models of experimental colitis and analysed whether these overlapping genes are of help to find new genes that could be used as general markers in human IBD...
  11. ncbi LEKTI fragments specifically inhibit KLK5, KLK7, and KLK14 and control desquamation through a pH-dependent interaction
    Celine Deraison
    Institut National de la Sante et de la Recherche Medicale, U563, Toulouse, F 31300 France
    Mol Biol Cell 18:3607-19. 2007
    ..The strongest inhibition was observed with D8-D11, toward KLK5. Kinetics analysis revealed that this interaction is rapid and irreversible, reflecting an extremely tight binding ..
  12. ncbi Prediction of ovarian cancer prognosis and response to chemotherapy by a serum-based multiparametric biomarker panel
    K Oikonomopoulou
    Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON M5G1L5, Canada
    Br J Cancer 99:1103-13. 2008
    ..A multiparametric model (c(0) of CA125, KLK5, KLK7 and rc(1) of CA125) provided predictive accuracy with area under the ROC curve (AUC) of 0.82 (0...
  13. ncbi Premature terminal differentiation and a reduction in specific proteases associated with loss of ABCA12 in Harlequin ichthyosis
    Anna C Thomas
    Queen Mary University of London, Barts and the London School of Medicine and Dentistry, London, E1 2AT, UK
    Am J Pathol 174:970-8. 2009
    ..Expression of the proteases kallikrein 5 and cathepsin D was dramatically reduced in both HI epidermis and the OTCC model...
  14. ncbi Acute skin eruptions that are positive for herpes simplex virus DNA polymerase in patients with stem cell transplantation: a new manifestation within the erythema multiforme reactive dermatoses
    Joseph W Burnett
    Department of Dermatology, University of Maryland, 4401 Roland Ave, Baltimore, MD 21210, USA
    Arch Dermatol 144:902-7. 2008
    Patients with stem cell transplantation (SCT) develop erythematous eruptions (SCTE) that are often misdiagnosed and poorly treated. Latent herpes simplex virus (HSV) is likely to be reactivated by SCT-associated immunosuppression...
  15. ncbi Analyzing the protease web in skin: meprin metalloproteases are activated specifically by KLK4, 5 and 8 vice versa leading to processing of proKLK7 thereby triggering its activation
    Anke Ohler
    Institute of Zoology, Cell and Matrix Biology, Johannes Gutenberg University, Mainz, Germany
    Biol Chem 391:455-60. 2010
    ..Here, we identify human kallikrein-related peptidases (KLKs) 4, 5, and 8 to be specific activators of meprins. KLK5 is capable of activating both metalloproteases...
  16. ncbi Increased serine protease activity and cathelicidin promotes skin inflammation in rosacea
    Kenshi Yamasaki
    Division of Dermatology, University of California, San Diego, and VA San Diego Health Care System, 3350 La Jolla Village Drive, San Diego, California 92161, USA
    Nat Med 13:975-80. 2007
    ..peptides are a result of a post-translational processing abnormality associated with an increase in stratum corneum tryptic enzyme (SCTE) in the epidermis...
  17. ncbi Trapping efficiencies of cultivated and natural riparian vegetation of northern Laos
    Olga Vigiak
    International Water Management Institute, IWMI Laos, Vientiane, Lao PDR
    J Environ Qual 37:889-97. 2008
    ..Water trapping efficiency (WTE) and sediment concentration trapping efficiency (SCTE) were calculated on an event basis; means and 95% confidence intervals (CIs) were estimated with a bootstrapping ..
  18. ncbi Defining the extended substrate specificity of kallikrein 1-related peptidases
    Carla A Borgono
    Department of Laboratory Medicine and Pathobiology, University of Toronto and Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, ON, Canada
    Biol Chem 388:1215-25. 2007
    ..recognition motifs based on optimal subsite occupancy were as follows: VI-QSAV-QL-R for KLK4; YFWGPV-RK-NSFAM-R for KLK5; VY-R-LFM-R for KLK13; and YW-KRSAM-HNSPA-R for KLK14...
  19. ncbi Kallikrein 5 induces atopic dermatitis-like lesions through PAR2-mediated thymic stromal lymphopoietin expression in Netherton syndrome
    Anaïs Briot
    Institut National de la Sante et de la Recherche Medicale, U563, Toulouse F 31300, France
    J Exp Med 206:1135-47. 2009
    ..Collectively, these data establish that uncontrolled KLK5 activity in NS epidermis can trigger atopic dermatitis (AD)-like lesions, independently of the environment and the ..
  20. ncbi Human kallikrein 3 (prostate specific antigen) and human kallikrein 5 expression in salivary gland tumors
    M R Darling
    Division of Oral Pathology, Department of Pathology, University of Western Ontario, London, Ontario N6A 5C1, Canada
    Int J Biol Markers 21:201-5. 2006
    The human kallikrein 5 protein (hK5) is expressed in many normal tissues, most notably in skin, breast, salivary gland and esophagus. It has also been shown to be a potential biomarker for breast, ovarian and testicular cancer...
  21. ncbi Alternative splicing variant of kallikrein-related peptidase 8 as an independent predictor of unfavorable prognosis in lung cancer
    Chris Planque
    Universite Francois Rabelais de Tours, Tours, France
    Clin Chem 56:987-97. 2010
    ..We undertook this study to evaluate the usefulness of mRNA isoforms encoded by the KLK8 (kallikrein-related peptidase 8) gene as prognostic markers for lung cancer...
  22. ncbi Long-term treatment with moisturizers affects the mRNA levels of genes involved in keratinocyte differentiation and desquamation
    Izabela Buraczewska
    Department of Medical Sciences, Dermatology and Venereology, University Hospital, 751 85 Uppsala, Sweden
    Arch Dermatol Res 301:175-81. 2009
    ..Treatment with one test moisturizer increased gene expression of involucrin, transglutaminase 1, kallikrein 5, and kallikrein 7, while the other moisturizer affected only expression of cyclin-dependent kinase inhibitor 1A...
  23. ncbi A heterozygous null mutation combined with the G1258A polymorphism of SPINK5 causes impaired LEKTI function and abnormal expression of skin barrier proteins
    W L Di
    Immunobiology Unit, UCL Institute of Child Health, 30 Guilford Street, London, UK
    Br J Dermatol 161:404-12. 2009
    ..G1258A polymorphism in SPINK5 may be associated with atopic dermatitis, which shares several clinical features with NS...
  24. ncbi Pygo1 and Pygo2 roles in Wnt signaling in mammalian kidney development
    Kristopher R Schwab
    Division of Developmental Biology, Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    BMC Biol 5:15. 2007
    ..To better understand the functions of Pygopus-mediated canonical Wnt signaling in kidney development, targeted mutations were made in the two mammalian orthologs, Pygo1 and Pygo2...
  25. ncbi The protein therapy of kallikrein in cerebral ischemic reperfusion injury
    Yuping Tang
    Department of Neurology, Huashan Hospital, Fudan University, Number 12 Wulumuqi Mid Road, Shanghai, PR China
    Curr Med Chem 16:4502-10. 2009
    ..We constructed the Protein Transduction Domain-Kallikrein (PTD-Kallikrein), checked its function of penetration and biotoxicity, and observed its influence on neurons and ischemic brain tissues...
  26. ncbi Role of tissue kallikrein-related peptidases in cervical mucus remodeling and host defense
    Julie L V Shaw
    Department of Pathology and Laboratory Medicine and Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto M5T 3L9, ON, Canada and Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto M5G 1L5, ON, Canada
    Biol Chem 389:1513-22. 2008
    ..b>KLK5 can digest defensin-1alpha, suggesting it may aid in cervico-vaginal host defense...
  27. ncbi Dichotomous effect of ultraviolet B on the expression of corneodesmosomal enzymes in human epidermal keratinocytes
    Megumi Nin
    Department of Dermatology, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Kawaramachi Hirokoji, Kamigyo ku, Kyoto 602 8566, Japan
    J Dermatol Sci 54:17-24. 2009
    The stratum corneum chymotryptic enzyme (SCCE) and the stratum corneum tryptic enzyme (SCTE) are serine proteases of the kallikrein family that are encoded by the KLK7 and KLK5 genes, respectively...
  28. ncbi Circulating biomarker tissue kallikrein-related peptidase KLK5 impacts ovarian cancer patients' survival
    J Dorn
    Department of Obstetrics and Gynecology, Technical University of Munich, Munich, Germany
    Ann Oncol 22:1783-90. 2011
    ..Kallikrein-related peptidases, including KLK5, have been reported to play an important role in the course of the disease.
  29. ncbi α2 Integrin-Dependent Suppression of Pancreatic Adenocarcinoma Cell Invasion Involves Ectodomain Regulation of Kallikrein-Related Peptidase-5
    Chia Yao Lee
    Moores Cancer Center, University of California, San Diego, La Jolla, CA 92093, USA
    J Oncol 2011:365651. 2011
    ..Affymetrix profiling revealed that kallikrein-related peptidase-5 (KLK5) was specifically upregulated by α2, and reduced α2 and KLK5 expression was observed in poorly differentiated ..
  30. ncbi Proteolytic activation cascade of the Netherton syndrome-defective protein, LEKTI, in the epidermis: implications for skin homeostasis
    Paola Fortugno
    Laboratory of Molecular and Cell Biology, Istituto Dermopatico dell Immacolata IDI IRCCS, Rome, Italy
    J Invest Dermatol 131:2223-32. 2011
    ..LEKTI fragments in the uppermost epidermis, showing that the ratios between LEKTI polypeptides and active KLK5 are compatible with a fine-tuned inhibition...
  31. ncbi Multiple kallikrein (KLK 5, 7, 8, and 10) expression in squamous cell carcinoma of the oral cavity
    Jason R Pettus
    Department of Pathology and Anatomical Sciences, University of Missouri School of Medicine, Columbia, MO 65212, USA
    Histol Histopathol 24:197-207. 2009
    ..qPCR analysis revealed 2.8-, 5.3-, 4.0-, and 3.5-fold increases in gene expression for KLK5, 7, 8, and 10, respectively, in SCC25-uPAR+ versus SCC25-uPAR-KD...
  32. ncbi Down-regulation of kallikrein-related peptidase 5 (KLK5) expression in breast cancer patients: a biomarker for the differential diagnosis of breast lesions
    Margaritis Avgeris
    Department of Biochemistry and Molecular Biology, University of Athens, Panepistimiopolis, 15701 Athens, Greece
    Clin Proteomics 8:5. 2011
    ..abstract:..
  33. ncbi Two new compounds, β-ScTe and Y(3)Au(2), and a reassessment of Y(2)Au
    Ping Chai
    Department of Chemistry, Iowa State University, Ames, IA 50010, USA
    Acta Crystallogr C 67:i53-i55. 2011
    Two new compounds, β-ScTe (scandium telluride) and Y(3)Au(2) (triyttrium digold), have been synthesized by high-temperature solid-state techniques and their crystal structures, along with that of Y(2)Au (diyttrium gold), have been ..
  34. ncbi Inhibition of transcription factor specificity protein 1 alters the gene expression profile of keratinocytes leading to upregulation of kallikrein-related peptidases and thymic stromal lymphopoietin
    Lianghua Bin
    Department of Pediatrics, National Jewish Health, Denver, Colorado 80206, USA
    J Invest Dermatol 131:2213-22. 2011
    ..Strikingly, six kallikrein (KLK)-related peptidase genes, namely KLK5, KLK6, KLK7, KLK8, KLK10, and KLK12, were upregulated in NHKs following Sp1 silencing...
  35. ncbi Molecular signatures associated with transformation and progression to breast cancer in the isogenic MCF10 model
    Dong Keun Rhee
    Department of Biology, College of Life Science and Biotechnology, Yonsei University, Seoul 120 749, Republic of Korea
    Genomics 92:419-28. 2008
    ..The data presented here may facilitate the identification and functional analyses of prognostic biomarkers for breast cancer...
  36. ncbi Inhibition of kallikrein-related peptidases by the serine protease inhibitor of Kazal-type 6
    Tomasz Kantyka
    Department of Dermatology, University Hospital Schleswig Holstein, Campus Kiel, Schittenhelmstr 7, D 24105 Kiel, Germany
    Peptides 32:1187-92. 2011
    ..Recently, we discovered that SPINK6 is expressed in human skin and inhibits KLK5, KLK7, KLK14 but not KLK8...
  37. ncbi Biological evaluation and docking studies of natural isocoumarins as inhibitors for human kallikrein 5 and 7
    Thiago S P Teixeira
    Instituto de Ciências Biológicas e Naturais, Universidade Federal do Triangulo Mineiro, Uberaba, MG, Brazil
    Bioorg Med Chem Lett 21:6112-5. 2011
    Human kallikrein 5 and 7 (KLK5 and KLK7) are trypsin-like and chymotrypsin-like serine proteases, respectively, and promising targets for the treatment of skin desquamation, inflammation and cancer...
  38. ncbi Depth profiling of stratum corneum biophysical and molecular properties
    D Mohammed
    Department of Pharmaceutics, School of Pharmacy, 29 39 Brunswick Square, London WC1N 1AX, UK
    Br J Dermatol 164:957-65. 2011
    ..The barrier function of the skin may be characterized by a number of biophysical and molecular methods. Variation in the barrier properties as a function of depth has not been explored in detail...
  39. ncbi TLR2 expression is increased in rosacea and stimulates enhanced serine protease production by keratinocytes
    Kenshi Yamasaki
    Division of Dermatology, Department of Medicine, University of California, San Diego, VA San Diego Health Care System, San Diego, California, USA
    J Invest Dermatol 131:688-97. 2011
    ..treatment with TLR2 ligands, and analysis of TLR2-deficient mice resulted in a calcium-dependent release of kallikrein 5 from keratinocytes, a critical protease involved in the pathogenesis of rosacea...
  40. ncbi Identification of lympho-epithelial Kazal-type inhibitor 2 in human skin as a kallikrein-related peptidase 5-specific protease inhibitor
    Ulf Meyer-Hoffert
    Department of Dermatology, University Hospital Schleswig Holstein, Campus Kiel, Kiel, Germany
    PLoS ONE 4:e4372. 2009
    ..Since many KLKs are expressed in human skin with KLK5 being considered as one of the most important KLKs in skin desquamation, we proposed that more inhibitors are ..
  41. ncbi Self-improvement of keratinocyte differentiation defects during skin maturation in ABCA12-deficient harlequin ichthyosis model mice
    Teruki Yanagi
    Department of Dermatology, Hokkaido University Graduate School of Medicine, N15 W7, Kita ku, Sapporo 060 8638, Japan
    Am J Pathol 177:106-18. 2010
    ..conversion and reduced protein expression of the differentiation-specific molecules, loricrin, kallikrein 5, and transglutaminase 1, although their mRNA expression was up-regulated...
  42. ncbi Blood biomarker levels to aid discovery of cancer-related single-nucleotide polymorphisms: kallikreins and prostate cancer
    Robert J Klein
    Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Cancer Prev Res (Phila) 3:611-9. 2010
    ..874 versus 0.866), providing proof in principle to clinical application for our findings...
  43. ncbi Gene expression signatures differentiate ovarian/peritoneal serous carcinoma from breast carcinoma in effusions
    Ben Davidson
    Division of Pathology, Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway
    J Cell Mol Med 15:535-44. 2011
    ..Genes overexpressed in ovarian/peritoneal carcinoma included SPON1, RBP1, MFGE8, TM4SF12, MMP7, KLK5/6/7, FOLR1/3,PAX8, APOL2 and NRCAM...
  44. ncbi KLK5 gene expression is severely upregulated in androgen-independent prostate cancer cells after treatment with the chemotherapeutic agents docetaxel and mitoxantrone
    Konstantinos Mavridis
    Department of Biochemistry and Molecular Biology, University of Athens, Greece
    Biol Chem 391:467-74. 2010
    Kallikrein-related peptidases (KLKs), including KLK5, have been proposed as promising biomarkers for prostate cancer diagnosis and prognosis. In the present study, we report that distinct augmentations (up to 6...
  45. ncbi Isolation of SPINK6 in human skin: selective inhibitor of kallikrein-related peptidases
    Ulf Meyer-Hoffert
    Department of Dermatology, University Hospital Schleswig Holstein, D 24105 Kiel, Germany
    J Biol Chem 285:32174-81. 2010
    ..SPINK6 expression was decreased in lesions of atopic dermatitis. Using KLK5, KLK7, KLK8, KLK14, thrombin, trypsin, plasmin, matriptase, prostasin, mast cell chymase, cathepsin G, neutrophil ..
  46. ncbi Kallikrein expression and cathelicidin processing are independently controlled in keratinocytes by calcium, vitamin D(3), and retinoic acid
    Shin Morizane
    Division of Dermatology, Department of Medicine, University of California, San Diego, San Diego, CA, USA
    J Invest Dermatol 130:1297-306. 2010
    ..The serine proteases kallikrein 5 (KLK5) and kallikrein 7 (KLK7) control enzymatic processing of cathelicidin precursor in the skin and regulate ..
  47. ncbi Circumscribed palmo-plantar hypokeratosis: a disease of desquamation? Immunohistological study of five cases and literature review
    J Kanitakis
    Department of Dermatology Pav R and Laboratory of Dermatopathology Bldg 10, Ed Herriot Hospital, Lyon cx 03, France
    J Eur Acad Dermatol Venereol 25:296-301. 2011
    ..Circumscribed palmoplantar hypokeratosis (CPH) is a recently recognized, rarely reported dermatosis that shows characteristic clinicopathological features; however, its pathogenesis remains unknown...
  48. ncbi Association between kallikrein-related peptidases (KLKs) and macroscopic indicators of semen analysis: their relation to sperm motility
    Nashmil Emami
    Department of Laboratory Medicine and Pathobiology, University of Toronto, ON, Canada
    Biol Chem 390:921-9. 2009
    ..In conclusion, the expression level of several seminal plasma KLKs correlates with liquefaction and viscosity indicators of semen quality and may aid in their differential diagnosis and etiology...
  49. ncbi Parallel underexpression of kallikrein 5 and kallikrein 7 mRNA in breast malignancies
    Xiaoqing Li
    Department of Biochemistry and Molecular Biology, Tianjin Medical University Cancer Institute and Hospital, Tianjin, 300060 China
    Cancer Sci 100:601-7. 2009
    ..However, the expression levels of KLK5 and KLK7 in benign breast tissues and metastases, and the relationship between KLK5 and KLK7, have not been ..
  50. ncbi Structural characterization and expression of five novel canine kallikrein-related peptidases in mammary cancer
    Katerina Angelopoulou
    Laboratory of Biochemistry and Toxicology, School of Veterinary Medicine, Aristotle University of Thessaloniki, Thessaloniki, 54124, Greece
    Mamm Genome 21:516-24. 2010
    ..We demonstrated that the GenBank sequences that were predicted in silico to represent the canine orthologs of human KLK5, KLK6, KLK7, and KLK8 mRNAs were correct, whereas the one corresponding to the canine KLK4 had a major ..
  51. ncbi Impact of cytogenetic and genomic aberrations of the kallikrein locus in ovarian cancer
    Jane Bayani
    Department of Applied Molecular Oncology, Ontario Cancer Institute, Princess Margaret Hospital, University Health Network, Toronto, Ontario, M5G 2M9, Canada
    Mol Oncol 2:250-60. 2008
    ..In this initial study, we introduce the potential for long-range chromosomal effects and copy number as a mechanism for the previously reported aberrant expression of many KLK genes in ovarian cancers...
  52. ncbi Quantitative analysis of human kallikrein 5 (KLK5) expression in prostate needle biopsies: an independent cancer biomarker
    Dimitrios Korbakis
    Department of Biochemistry and Molecular Biology, Faculty of Biology, University of Athens, Athens, Greece
    Clin Chem 55:904-13. 2009
    b>Kallikrein 5 (KLK5), a recently cloned member of the kallikrein family, codes for the secreted protein KLK5. Active KLK5 protein has a trypsin activity, and the expression of KLK5 gene seems to be regulated by steroid hormones...
  53. ncbi SPINK9: a selective, skin-specific Kazal-type serine protease inhibitor
    Maria Brattsand
    Department of Dermatology and Venereology, Public Health and Clinical Medicine, Umea University, Umea, Sweden
    J Invest Dermatol 129:1656-65. 2009
    ..KLKs) 5, 7, 8, and 14, thrombin, trypsin, and chymotrypsin, inhibition with recombinant SPINK9 was seen only for KLK5 using low molecular weight substrates, with an apparent K(i) of 65 nM...
  54. ncbi The use of kallikrein-related peptidases as adjuvant prognostic markers in colorectal cancer
    M Talieri
    Department of Cellular Physiology, G Papanicolaou Research Center of Oncology, Saint Savvas Hospital, Athens, Greece
    Br J Cancer 100:1659-65. 2009
    ..Nine KLKs (KLK5-8, KLK10, KLK11, KLK13-15) were measured using ELISA assays in cytosolic extracts of 122 colon cancer tissues and ..
  55. ncbi Kallikrein-related peptidase-8 (KLK8) is an active serine protease in human epidermis and sweat and is involved in a skin barrier proteolytic cascade
    Azza Eissa
    Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario M5S 1A8, Canada
    J Biol Chem 286:687-706. 2011
    ..We also demonstrated that KLK5 and lysyl endopeptidase activate latent pro-KLK8, whereas active KLK8 targets pro-KLK11, pro-KLK1, and LL-37 ..
  56. ncbi Rosacea - global diversity and optimized outcome: proposed international consensus from the Rosacea International Expert Group
    B E Elewski
    Department of Dermatology, University of Alabama, Birmingham, AL, USA
    J Eur Acad Dermatol Venereol 25:188-200. 2011
    ....
  57. ncbi Stratum corneum tryptic enzyme in normal epidermis: a missing link in the desquamation process?
    I E Ekholm
    Department of Public Health and Clinical Medicine, Dermatology and Venereology, Umea University, Sweden
    J Invest Dermatol 114:56-63. 2000
    ..It has also been suggested that other proteases, especially stratum corneum tryptic enzyme, may be involved. Stratum corneum tryptic enzyme has been purified and its cDNA has been cloned...
  58. ncbi Identification of murine uterine genes regulated in a ligand-dependent manner by the progesterone receptor
    Jae Wook Jeong
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Endocrinology 146:3490-505. 2005
    ..P 450 26a1 (Cyp26a1), alcohol dehydrogenase 5, and aldehyde dehydrogenase 1a1 (Aldh1a1); kallikrein genes, Klk5 and Klk6; and specific transcription factors, GATA-2 and Cited2 [cAMP-corticosterone-binding protein/p300-..
  59. ncbi KLK5 and KLK7, two members of the human tissue kallikrein family, are differentially expressed in lung cancer
    Chris Planque
    INSERM, U618, Protéases et Vectorisation Pulmonaires, Universite Francois Rabelais, Tours 37032, France
    Biochem Biophys Res Commun 329:1260-6. 2005
    ..Using RT-PCR and Western blotting, we demonstrated the expression of both KLK5 and KLK7, and their respective proteins (hK5 and hK7) in tumoral and nontumoral lung tissues...
  60. ncbi Biochemical and enzymatic characterization of human kallikrein 5 (hK5), a novel serine protease potentially involved in cancer progression
    Iacovos P Michael
    Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada
    J Biol Chem 280:14628-35. 2005
    Human kallikrein 5 (KLK5) is a member of the human kallikrein gene family of serine proteases. Preliminary results indicate that the protein, hK5, may be a potential serological marker for breast and ovarian cancer...
  61. ncbi LEKTI is localized in lamellar granules, separated from KLK5 and KLK7, and is secreted in the extracellular spaces of the superficial stratum granulosum
    Akemi Ishida-Yamamoto
    Department of Dermatology, Asahikawa Medical College, Midorigaoka Higashi 2 1 1 1, Asahikawa 078 8510, Japan
    J Invest Dermatol 124:360-6. 2005
    ..understand the functional role of LEKTI, we examined the localization of LEKTI together with kallikrein (KLK)7 and KLK5, possible targets of LEKTI, in the human epidermis, by confocal laser scanning microscopy and immunoelectron ..
  62. ncbi A proteolytic cascade of kallikreins in the stratum corneum
    Maria Brattsand
    Department of Public Health and Clinical Medicine, Dermatology and Venereology, Umea University, Umea, Sweden
    J Invest Dermatol 124:198-203. 2005
    ..We conclude that the enzymes studied may be part of a protease cascade in the stratum corneum, and that the observed pH effects may have physiological relevance...
  63. ncbi Kallikrein gene downregulation in breast cancer
    G M Yousef
    Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, Ontario, Canada
    Br J Cancer 90:167-72. 2004
    ..Our results indicate that at least four kallikrein genes (KLK5, 6, 8, 10) are downregulated in breast cancer...
  64. ncbi Expression and localization of tissue kallikrein mRNAs in human epidermis and appendages
    Nahoko Komatsu
    Department of Dermatology, Graduate School of Medical Science, School of Medicine, Kanazawa University, 13 1 Takara machi, Kanazawa 920 8641, Japan
    J Invest Dermatol 121:542-9. 2003
    ..Quantitative RT-PCR analysis showed abundant expression of KLK1 and KLK11 mRNA, moderate expression of KLK4, KLK5, KLK6, KLK7, and KLK13 mRNA, and low expression of KLK8 mRNA in normal human skin...
  65. ncbi Par2 inactivation inhibits early production of TSLP, but not cutaneous inflammation, in Netherton syndrome adult mouse model
    Anaïs Briot
    INSERM, U563, Toulouse, France
    J Invest Dermatol 130:2736-42. 2010
    ..This signaling is initiated by unrestricted kallikrein 5 (KLK5) activity, which directly activates proteinase-activated receptor 2 (PAR2)-mediated expression of TSLP ..
  66. ncbi Differential splicing of KLK5 and KLK7 in epithelial ovarian cancer produces novel variants with potential as cancer biomarkers
    Ying Dong
    The Center of Molecular Biotechnology, School of Life Sciences, Queensland University of Technology, Brisbane, Australia
    Clin Cancer Res 9:1710-20. 2003
    ..Two of these KLK genes (KLK5 and KLK7) and their proteins (hK5 and hK7) were first identified in the skin epidermis, where hK5 may be the ..
  67. ncbi Temporal and tissue-specific expression of kallikrein (Klk) genes and identification of a novel Klk messenger ribonucleic acid transcript during early development in the mouse
    C S Chan
    Centre for Molecular Biotechnology, School of Life Sciences, Queensland University of Technology, Brisbane, Queensland 4001, Australia
    Biol Reprod 61:621-8. 1999
    ..to elucidate the temporal and tissue-specific expression patterns of the mouse kallikreins Klk1, Klk3, Klk5, Klk9, and Klk21 during early development in the embryo, uterus, and decidua...
  68. ncbi Sequencing and expression analysis of the serine protease gene cluster located in chromosome 19q13 region
    L Gan
    Chiroscience R and D Inc 1631 220th St SE Bothell, WA 98021, USA
    Gene 257:119-30. 2000
    ..The proteases, excluding the kallikrein genes, share approximately 40% of their sequences suggesting that the serine protease gene cluster on chromosome 19q13 arose from ancient gene duplications...
  69. ncbi The new human kallikrein gene family: implications in carcinogenesis
    E P Diamandis
    Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, Ontario, Canada
    Trends Endocrinol Metab 11:54-60. 2000
    ..This brief review summarizes recent developments and possible applications of the newly defined and expanded human kallikrein gene locus...
  70. ncbi Identification of novel human kallikrein-like genes on chromosome 19q13.3-q13.4
    G M Yousef
    Department of Pathology, Mount Sinai Hospital, Toronto, Ontario, Canada
    Anticancer Res 19:2843-52. 1999
    ..These new genes, like the already known kallikreins, may have utility for diagnosis, monitoring and therapeutics of various cancers including those of the breast, prostate and testis...
  71. ncbi Expression analysis and prognostic significance of human kallikrein 11 in prostate cancer
    Panagiota Stavropoulou
    Department of Biochemistry and Molecular Biology, Faculty of Biology, University of Athens, 157 01 Athens, Greece
    Clin Chim Acta 357:190-5. 2005
    ..KLK11 has two alternative splicing isoforms, known as the brain type and prostate type. Many members of the human kallikrein gene family are differentially expressed in cancer and a few have potential as diagnostic/prognostic markers...
  72. ncbi Immunofluorometric quantification of human kallikrein 5 expression in ovarian cancer cytosols and its association with unfavorable patient prognosis
    Eleftherios P Diamandis
    Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, Canada
    Tumour Biol 24:299-309. 2003
    Human kallikrein 5 (hK5; encoded by the KLK5 gene) is a secreted serine protease expressed in hormonally regulated tissues, including the breast and ovary...
  73. ncbi Tissue-specific promoter utilisation of the kallikrein-related peptidase genes, KLK5 and KLK7, and cellular localisation of the encoded proteins suggest roles in exocrine pancreatic function
    Ying Dong
    Hormone Dependent Cancer Program, Institute of Health and Biomedical Innovation, Queensland University of Technology, Kelvin Grove, QLD 4059, Australia
    Biol Chem 389:99-109. 2008
    ..for expression of KLK4 to KLK15 identified pancreas as a common expression site for the gene cluster spanning KLK5 to KLK13, as well as for KLK15 which is located adjacent to KLK1...
  74. ncbi Association of kallikrein gene polymorphisms with intracranial aneurysms
    Shantel Weinsheimer
    Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, 3309 Gordon H Scott Hall of Basic Medical Sciences, 540 East Canfield Avenue, Detroit, MI 48201, USA
    Stroke 38:2670-6. 2007
    ..We investigated the association of single nucleotide polymorphisms (SNPs) in the kallikrein gene cluster with IA in the Finnish population...
  75. ncbi Proteomics analysis of conditioned media from three breast cancer cell lines: a mine for biomarkers and therapeutic targets
    Vathany Kulasingam
    Department of Laboratory Medicine and Pathobiology, Mount Sinai Hospital, University of Toronto, Toronto, Ontario M5G 1X5, Canada
    Mol Cell Proteomics 6:1997-2011. 2007
    ..a protease inhibitor, identified in the conditioned media of BT474 and MDA-MB-468 and the three kallikreins (KLK5, KLK6, and KLK10) were validated using an immunoassay on various serum and biological samples...
  76. ncbi A multiparametric serum kallikrein panel for diagnosis of non-small cell lung carcinoma
    Chris Planque
    Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada
    Clin Cancer Res 14:1355-62. 2008
    ..Here, we examined the clinical value of 11 members of the tissue kallikrein family as potential biomarkers for lung cancer diagnosis...
  77. ncbi Distribution of 15 human kallikreins in tissues and biological fluids
    Julie L V Shaw
    Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, Ontario, Canada
    Clin Chem 53:1423-32. 2007
    ..We characterized the protein and mRNA abundance patterns of all 15 KLKs in multiple panels of human tissues and biological fluids...
  78. ncbi Association of KLK5 overexpression with invasiveness of urinary bladder carcinoma cells
    Yasuo Shinoda
    Department of Molecular Cytogenetics, Medical Research Institute and School of Biomedical Science, Tokyo Medical and Dental University, Tokyo, Japan
    Cancer Sci 98:1078-86. 2007
    ..Expression levels of KLK5, -6, -8 and -9 were significantly increased in three cell lines with copy number gains of these KLK genes...
  79. ncbi Kallikreins as microRNA targets: an in silico and experimental-based analysis
    Tsz fung F Chow
    Department of Laboratory Medicine, and the Keenan Research Centre in the Li Ka Shing Knowledge Institute, St Michael s Hospital, Toronto M5B 1W8, Canada
    Biol Chem 389:731-8. 2008
    ..KLK10 is the most frequently targeted kallikrein, followed by KLK5 and KLK13. KLK1, KLK3, KLK8 and KLK12 do not have strongly predicted miRNA/KLK interactions...
  80. ncbi Structures and specificity of the human kallikrein-related peptidases KLK 4, 5, 6, and 7
    Mekdes Debela
    Max Planck Institut fur Biochemie, Proteinase Research Group, Am Klopferspitz 18, D 82152 Martinsried, Germany
    Biol Chem 389:623-32. 2008
    ..advances in the purification of 'new type' recombinant KLKs allowed solution of the crystal structures of KLK4, KLK5, KLK6, and KLK7...
  81. ncbi Characterization of mouse tissue kallikrein 5
    Sanath Rajapakse
    Laboratory of Molecular and Cellular Interactions, Faculty of Advanced Life Science, Hokkaido University, Sapporo, Japan
    Zoolog Sci 23:963-8. 2006
    ..Mouse tissue kallikrein 5 (Klk5) has long been thought to be one of these functional genes, but the gene product, mK5, has not been ..
  82. ncbi A potential role for multiple tissue kallikrein serine proteases in epidermal desquamation
    Carla A Borgono
    Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, University of Toronto, Toronto, Ontario M5G 1X5, Canada
    J Biol Chem 282:3640-52. 2007
    ..Two members of the human tissue kallikrein (KLK) family of (chymo)tryptic-like serine proteases, KLK5 and KLK7, are implicated in desquamation by digestion of (corneo)desmosomes and inhibition by desquamation-related ..
  83. ncbi Kallikrein-mediated proteolysis regulates the antimicrobial effects of cathelicidins in skin
    Kenshi Yamasaki
    Division of Dermatology, University of California, San Diego, and VA San Diego Health Care System, San Diego, California, USA
    FASEB J 20:2068-80. 2006
    ..Through the use of selective inhibitors, SELDI-TOF-MS, Western blot, and siRNA, the serine proteases stratum corneum tryptic enzyme (SCTE, kallikrein 5) and stratum corneum chymotryptic protease (SCCE, kallikrein 7) were shown to ..
  84. ncbi Proteinase-activated receptors, targets for kallikrein signaling
    Katerina Oikonomopoulou
    Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario M5G 1L5, Canada
    J Biol Chem 281:32095-112. 2006
    ..Our data indicate that in physiological settings, hKs may represent important endogenous regulators of the PARs and that different hKs can have differential actions on PAR(1), PAR(2), and PAR(4)...
  85. ncbi Kallikrein-related peptidase 14 may be a major contributor to trypsin-like proteolytic activity in human stratum corneum
    Kristina Stefansson
    Department of Public Health and Clinical Medicine, Dermatology and Venereology, Umea University, S 901 85 Umea, Sweden
    Biol Chem 387:761-8. 2006
    We have previously presented evidence that two human kallikrein-related peptidases, KLK5 (hK5, stratum corneum tryptic enzyme, SCTE) and KLK7 (hK7, stratum corneum chymotryptic enzyme, SCCE), which are abundant in the stratum corneum, may ..
  86. ncbi The new kallikrein-like gene, KLK-L2. Molecular characterization, mapping, tissue expression, and hormonal regulation
    G M Yousef
    Department of Pathology, Mount Sinai Hospital, Toronto M5G 1X5, Toronto, Ontario M5G 1L5, Canada
    J Biol Chem 274:37511-6. 1999
    ..KLK-L2 is expressed mainly in breast, brain, and testis and to a lesser extent in many other tissues. KLK-L2 is up-regulated by estrogens and progestins in the breast cancer cell line BT-474...
  87. ncbi Tissue-specific expression patterns and fine mapping of the human kallikrein (KLK) locus on proximal 19q13.4
    T J Harvey
    Centre for Molecular Biotechnology, School of Life Sciences, Queensland University of Technology, Brisbane, Queensland 4001, Australia
    J Biol Chem 275:37397-406. 2000
    ..In addition, like the rat, these genes are expressed at varying levels in a diverse range of tissues although they exhibit quite distinct patterns of expression...
  88. ncbi Purification, molecular cloning, and expression of a human stratum corneum trypsin-like serine protease with possible function in desquamation
    M Brattsand
    Department of Public Health, Umea University, SE 901 85 Umea, Sweden
    J Biol Chem 274:30033-40. 1999
    ..The function of this new protease, tentatively named stratum corneum tryptic enzyme, may be related to stratum corneum turnover and desquamation in the epidermis.
  89. ncbi Corneodesmosomal cadherins are preferential targets of stratum corneum trypsin- and chymotrypsin-like hyperactivity in Netherton syndrome
    Pascal Descargues
    Department of Functional Genetics of Epithelial Diseases, INSERM U563, Toulouse Cedex, France
    J Invest Dermatol 126:1622-32. 2006
    ..These defects were associated with premature degradation of corneodesmosomes. Stratum corneum tryptic enzyme (SCTE)-like and stratum corneum chymotryptic enzyme (SCCE)-like activities were increased, suggesting ..
  90. ncbi Structural basis of the zinc inhibition of human tissue kallikrein 5
    Mekdes Debela
    Max Planck Institut fur Biochemie, Proteinase Research Group, Am Klopferspitz 18, 82152 Martinsried, Germany
    J Mol Biol 373:1017-31. 2007
    Human kallikrein 5 (hK5) is a member of the tissue kallikrein family of serine peptidases...
  91. ncbi Down-regulation of the human kallikrein gene 5 (KLK5) in prostate cancer tissues
    George M Yousef
    Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, 600 University Avenue, Toronto, Ontario M5G 1X5, Canada
    Prostate 51:126-32. 2002
    ..Human glandular kallikrein (hK2; encoded by the KLK2 gene) is an emerging tumor marker for prostate cancer. KLK5 is a newly discovered human kallikrein gene which shares a high degree of homology and is located adjacent to KLK2 ..
  92. ncbi The human kallikrein protein 5 (hK5) is enzymatically active, glycosylated and forms complexes with two protease inhibitors in ovarian cancer fluids
    George M Yousef
    Department of Pathology and Laboratory Medicine, Division of Clinical Biochemistry, Mount Sinai Hospital, 600 University Avenue, M5G 1X5, Toronto, ON, Canada
    Biochim Biophys Acta 1628:88-96. 2003
    ..Human kallikrein gene 5 (KLK5) is a member of this family and encodes for a secreted serine protease (hK5)...
  93. ncbi Activation of proteinase-activated receptor-2 by human kallikrein-related peptidases
    Kristina Stefansson
    Department of Public Health and Clinical Medicine, Dermatology and Venereology, Umea University, Umea, Sweden
    J Invest Dermatol 128:18-25. 2008
    ..We found that KLK5 and KLK14, but neither KLK7 nor KLK8, induced PAR2 signalling...
  94. ncbi Degradation of corneodesmosome proteins by two serine proteases of the kallikrein family, SCTE/KLK5/hK5 and SCCE/KLK7/hK7
    Cecile Caubet
    UMR5165 Epidermis Differentiation and Rheumatoid Autoimmunity, CNRS P Sabatier University Institut Fédératif de Recherche 30 and INSERM CNRS Université P Sabatier Centre Hospitalier Universitaire, Toulouse, France
    J Invest Dermatol 122:1235-44. 2004
    ..have been implicated in this process: the stratum corneum chymotryptic enzyme (SCCE/KLK7/hK7) and the stratum corneum tryptic enzyme (SCTE/KLK5/hK5)...
  95. ncbi Treatment of PC3 prostate cancer cells with mitoxantrone, etoposide, doxorubicin and carboplatin induces distinct alterations in the expression of kallikreins 5 and 11
    Hellinida Thomadaki
    Department of Biochemistry and Molecular Biology, Faculty of Biology, University of Athens, Panepistimiopolis, 15701 Athens, Greece
    Thromb Haemost 101:373-80. 2009
    ..research approach, our objective was to investigate the possible alterations in the mRNA expression levels of KLK5 and KLK11 genes in prostate cancer cells PC3 as a response to treatment with mitoxantrone, etoposide, doxorubicin ..
  96. ncbi Human tissue kallikrein 5 is a member of a proteolytic cascade pathway involved in seminal clot liquefaction and potentially in prostate cancer progression
    Iacovos P Michael
    Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada
    J Biol Chem 281:12743-50. 2006
    ..Several lines of evidence suggest that hKs participate in proteolytic cascade pathways. Human kallikrein 5 (hK5) has trypsin-like activity, is able to self-activate, and is co-expressed in various tissues with other ..
  97. ncbi Differential expression of Kallikrein gene 5 in cancerous and normal testicular tissues
    George M Yousef
    Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, Ontario, Canada
    Urology 60:714-8. 2002
    Kallikrein gene 5 (KLK5; formerly designated as kallikrein-like gene 2, or human stratum corneum tryptic enzyme) is one of the new members of the human kallikrein gene family on chromosome 19q13.4...

Research Grants10

  1. Molecular Diagnostics for Malignant Effusion
    Ie Ming Shih; Fiscal Year: 2006
    ..allelic imbalance and increased DNA integrity) in tumor-released DNA and the secreted protein markers (HLA-G, kallikrein 5 and kallikrein 8) alone or in combination provide novel molecular approaches to increase the sensitivity and ..
  2. NATURE OF MAMMALIAN CUTANEOUS PERMEABILITY BARRIER
    Peter Elias; Fiscal Year: 2006
    ..possible pH-dependent SC function, regulated by two serine proteases: the SC chymotryptic (SCCE) and tryptic (SCTE) enzymes...