KLK10

Summary

Gene Symbol: KLK10
Description: kallikrein related peptidase 10
Alias: NES1, PRSSL1, kallikrein-10, breast normal epithelial cell associated serine protease, kallikrein 10 protein 1, kallikrein 10 protein 12, kallikrein 10 protein 13, kallikrein 10 protein 2, kallikrein 10 protein 3, kallikrein 10 protein 4, kallikrein 10 protein 5, kallikrein 10 protein 7, kallikrein 10 protein 8, kallikrein 10 protein 9, normal epithelial cell-specific 1, protease serine-like 1
Species: human
Products:     KLK10

Top Publications

  1. Liu X, Wazer D, Watanabe K, Band V. Identification of a novel serine protease-like gene, the expression of which is down-regulated during breast cancer progression. Cancer Res. 1996;56:3371-9 pubmed
    ..Based on its selective expression in MECs compared with fibroblasts, the corresponding gene is designated NES1 (normal epithelial cell-specific 1)...
  2. Huang W, Tian X, Wu Y, Zhong J, Yu L, Hu S, et al. Suppression of gastric cancer growth by baculovirus vector-mediated transfer of normal epithelial cell specific-1 gene. World J Gastroenterol. 2008;14:5810-5 pubmed
    To study the inhibitory effect of baculovirus-mediated normal epithelial cell specific-1 (NES1) gene therapy on gastric cancer (GC) in vitro and in vivo...
  3. Koh S, Razvi K, Chan Y, Narasimhan K, Ilancheran A, Low J, et al. The association with age, human tissue kallikreins 6 and 10 and hemostatic markers for survival outcome from epithelial ovarian cancer. Arch Gynecol Obstet. 2011;284:183-90 pubmed publisher
    To assess known cancer biomarkers CA-125, human tissue kallikreins KLK6 and KLK10, hemostatic markers and age with 5-year survival outcome from epithelial ovarian cancer...
  4. Zhang Y, Bhat I, Zeng M, Jayal G, Wazer D, Band H, et al. Human kallikrein 10, a predictive marker for breast cancer. Biol Chem. 2006;387:715-21 pubmed
    ..NES1 is located on chromosome 19q13.4 within the kallikrein locus and thus was designated as human kallikrein 10 (hK10), although we have been unable to detect any protease activity...
  5. Sidiropoulos M, Pampalakis G, Sotiropoulou G, Katsaros D, Diamandis E. Downregulation of human kallikrein 10 (KLK10/NES1) by CpG island hypermethylation in breast, ovarian and prostate cancers. Tumour Biol. 2005;26:324-36 pubmed
    The human kallikrein 10 (KLK10)/normal epithelial cell-specific-1 (NES1) gene is highly expressed in normal mammary, ovary and prostate cells, but its expression is dramatically decreased in cancer cell lines...
  6. Petraki C, Gregorakis A, Papanastasiou P, Karavana V, Luo L, Diamandis E. Immunohistochemical localization of human kallikreins 6, 10 and 13 in benign and malignant prostatic tissues. Prostate Cancer Prostatic Dis. 2003;6:223-7 pubmed
    ..Expression levels did not correlate with aggressiveness and they do not seem to have value for prostate cancer prognosis. ..
  7. Petraki C, Karavana V, Luo L, Diamandis E. Human kallikrein 10 expression in normal tissues by immunohistochemistry. J Histochem Cytochem. 2002;50:1247-61 pubmed
    ..name kallikrein gene 10, KLK10) was recently cloned and encodes for a putative secreted serine protease (human kallikrein 10, hK10)...
  8. Luo L, Herbrick J, Scherer S, Beatty B, Squire J, Diamandis E. Structural characterization and mapping of the normal epithelial cell-specific 1 gene. Biochem Biophys Res Commun. 1998;247:580-6 pubmed
    The normal epithelial cell-specific 1 (NES1) gene is a recently identified novel serine protease-like gene which is down-regulated during breast cancer progression...
  9. Goyal J, Smith K, Cowan J, Wazer D, Lee S, Band V. The role for NES1 serine protease as a novel tumor suppressor. Cancer Res. 1998;58:4782-6 pubmed
    ..56: 3371-3379, 1996), we isolated a novel serine protease-like gene--Normal Epithelial Cell Specific-1 (NES1)--that is expressed in normal mammary epithelial cells but is down-regulated in most breast cancer cell lines...

More Information

Publications78

  1. Sugimoto S, Morizane S, Nomura H, Kobashi M, Sugihara S, Iwatsuki K. Toll-like receptor signaling induces the expression of lympho-epithelial Kazal-type inhibitor in epidermal keratinocytes. J Dermatol Sci. 2018;92:181-187 pubmed publisher
    ..The gene expressions of KLK6, KLK10, KLK11, and KLK13 were also increased by poly (I:C)...
  2. Panagopoulou M, Karaglani M, Balgkouranidou I, Biziota E, Koukaki T, Karamitrousis E, et al. Circulating cell-free DNA in breast cancer: size profiling, levels, and methylation patterns lead to prognostic and predictive classifiers. Oncogene. 2019;: pubmed publisher
    ..The methylation status of a panel of cancer-related genes chosen based on previous expression and epigenetic data (KLK10, SOX17, WNT5A, MSH2, GATA3) was assessed by quantitative methylation-specific PCR...
  3. Hu Y, Liu X, Zhang A, Zhou H, Liu Z, Chen H, et al. CHD3 facilitates vRNP nuclear export by interacting with NES1 of influenza A virus NS2. Cell Mol Life Sci. 2015;72:971-82 pubmed publisher
    ..However, even though the nuclear export signal 1 (NES1) of NS2 does not play a requisite role in NS2-Crm1 interaction, there is no doubt that NES1 is crucial for vRNP ..
  4. El Sherbini M, Sallam M, Shaban E, El Shalakany A. Diagnostic value of serum kallikrein-related peptidases 6 and 10 versus CA125 in ovarian cancer. Int J Gynecol Cancer. 2011;21:625-32 pubmed publisher
    To assess the diagnostic value of serum KLK6 and KLK10 in patients with ovarian tumor in comparison to serum CA125...
  5. Ehrenfeld P, Manso L, Pavicic M, Matus C, Borquez C, Lizama A, et al. Bioregulation of kallikrein-related peptidases 6, 10 and 11 by the kinin B₁ receptor in breast cancer cells. Anticancer Res. 2014;34:6925-38 pubmed
    ..whether stimulation of breast cancer cells with a B1R agonist would modify the cellular levels of KLK6, KLK10 and KLK11, three kallikrein-related peptidases with a still poorly-understood biological role in breast cancer...
  6. Månberg A, Bradley F, Qundos U, Guthrie B, Birse K, Noël Romas L, et al. A high throughput bead-based affinity assay enables analysis of genital protein signatures in women at risk of HIV infection. Mol Cell Proteomics. 2018;: pubmed publisher
    ..By combining several methods of analysis, a total of five proteins (CAPG, KLK10, SPRR3, elafin/PI3, CSTB) were consistently associated with this study group...
  7. Dai J, Bercury K, Jin W, Macklin W. Olig1 Acetylation and Nuclear Export Mediate Oligodendrocyte Development. J Neurosci. 2015;35:15875-93 pubmed publisher
    ..NES) localized in the basic helix-loop-helix domain and one specific acetylation site at Lys 150 (human Olig1) in NES1. Olig1 acetylation and deacetylation are regulated by the acetyltransferase CREB-binding protein and the histone ..
  8. Xu L, Duan Y, Wang P, Yin H. MiR-199b-5p promotes tumor growth and metastasis in cervical cancer by down-regulating KLK10. Biochem Biophys Res Commun. 2018;503:556-563 pubmed publisher
    MiR-199 b-5p and kallikrein-related peptidase 10 (KLK10) are related to various disease processes and pathogenesis. However, little is known about the molecular mechanisms of miR-199 b-5p and KLK10 in human cervical cancer...
  9. Lizama A, Andrade Y, Colivoro P, Sarmiento J, Matus C, Gonzalez C, et al. Expression and bioregulation of the kallikrein-related peptidases family in the human neutrophil. Innate Immun. 2015;21:575-86 pubmed publisher
    ..RT-PCR showed that blood neutrophils expressed only KLK1, KLK4, KLK10, KLK13, KLK14 and KLK15 mRNAs, whereas the non-differentiated HL-60 cells expressed most of them, with exception ..
  10. Kern R, Lindholm Perry A, Freetly H, Snelling W, Kern J, Keele J, et al. Transcriptome differences in the rumen of beef steers with variation in feed intake and gain. Gene. 2016;586:12-26 pubmed publisher
    ..Among those are KLK10, IRX3, COL1A1, CRELD2, HDAC10, IFITM3, and VIM...
  11. Cao X, Zhang X, Yang M, Hu L, Jiang S, Tian G, et al. Aberrant upregulation of KLK10 promotes metastasis via enhancement of EMT and FAK/SRC/ERK axis in PDAC. Biochem Biophys Res Commun. 2018;499:584-593 pubmed publisher
    ..In this study, by data mining of GEO datasets, we have identified KLK10 is upregulated gene in PDAC...
  12. El Sherbini M, Mansour A, Sallam M, Shaban E, Shehab ElDin Z, El Shalakany A. KLK10 exon 3 unmethylated PCR product concentration: a new potential early diagnostic marker in ovarian cancer? - A pilot study. J Ovarian Res. 2018;11:32 pubmed publisher
    b>KLK10 exon 3 hypermethylation correlated to tumor-specific lack of KLK10 expression in cancer cell lines and primary tumors...
  13. Mohammed F, Khajah M, Yang M, Brackenbury W, Luqmani Y. Blockade of voltage-gated sodium channels inhibits invasion of endocrine-resistant breast cancer cells. Int J Oncol. 2016;48:73-83 pubmed publisher
    ..At high concentrations, PHT inhibited motility while TTX reduced cell proliferation. Pharmacological or genetic blockade of Nav1.5 may serve as a potential anti-metastatic therapy for breast cancer. ..
  14. Kim J, Park S, Kwak M, Go J, Koh E, Song S, et al. Characterization of Changes in Global Genes Expression in the Distal Colon of Loperamide-Induced Constipation SD Rats in Response to the Laxative Effects of Liriope platyphylla. PLoS ONE. 2015;10:e0129664 pubmed publisher
    ..The major genes in the down-regulated categories included Slc9a5, klk10, Fgf15, and Alpi, whereas the major genes in the recovered categories were Cyp2b2, Ace, G6pc, and Setbp1...
  15. Potter C, Zhu W, Razafsky D, Ruzycki P, Kolesnikov A, Doggett T, et al. Multiple Isoforms of Nesprin1 Are Integral Components of Ciliary Rootlets. Curr Biol. 2017;27:2014-2022.e6 pubmed publisher
    ..filaments also dock to the NE through the specific recruitment of an ?600-kDa endogenous isoform of Nesprin1 (Nes1600kDa) and of Sun2...
  16. Drucker K, Gianinni C, Decker P, Diamandis E, Scarisbrick I. Prognostic significance of multiple kallikreins in high-grade astrocytoma. BMC Cancer. 2015;15:565 pubmed publisher
    ..In this study we determined KLK1, KLK6, KLK7, KLK8, KLK9 and KLK10 protein expression in two independent tissue microarrays containing 60 grade IV and 8 grade III astrocytoma ..
  17. Suarez Vega A, Gutiérrez Gil B, Arranz J. Transcriptome expression analysis of candidate milk genes affecting cheese-related traits in 2 sheep breeds. J Dairy Sci. 2016;99:6381-6390 pubmed publisher
    ..These genes were mainly linked to endogenous protease activity (CTSL, CTSK, KLK10, KLK6, SERPINE2)...
  18. Yang F, Feng S, Lai T, Hu M. A calreticulin-dependent nuclear export signal is involved in the regulation of liver receptor homologue-1 protein folding. Biochem J. 2015;471:199-209 pubmed publisher
    ..Mutation of leucine residues in NES1 or NES2 abolished nuclear export, indicating that both NES1 and NES2 motifs are essential for full nuclear export ..
  19. Geybels M, Alumkal J, Luedeke M, Rinckleb A, Zhao S, Shui I, et al. Epigenomic profiling of prostate cancer identifies differentially methylated genes in TMPRSS2:ERG fusion-positive versus fusion-negative tumors. Clin Epigenetics. 2015;7:128 pubmed publisher
    ..53E-29) were identified: C3orf14, CACNA1D, GREM1, KLK10, NT5C, PDE4D, RAB40C, SEPT9, and TRIB2, several of which had a corresponding alteration in mRNA expression...
  20. Huang W, Zhong J, Wu L, Yu L, Tian X, Zhang Y, et al. Downregulation and CpG island hypermethylation of NES1/hK10 gene in the pathogenesis of human gastric cancer. Cancer Lett. 2007;251:78-85 pubmed
    The normal epithelial cell-specific-1 (NES1)/Kallikrein 10 gene is proposed to be a novel putative tumor suppressor gene in several malignant diseases. The role of NES1 gene in gastric cancer has not been fully understood...
  21. Li L, Xu N, Fan N, Meng Q, Luo W, Lv L, et al. Upregulated KLK10 inhibits esophageal cancer proliferation and enhances cisplatin sensitivity in vitro. Oncol Rep. 2015;34:2325-32 pubmed publisher
    The kallikrein-related peptidase 10 (KLK10) gene has tumor-suppressive function in various types of human cancer. However, previous studies showed that KLK10 also acts as an oncogene and is upregulated in gastrointestinal tumors...
  22. . Proceedings of the 1st International Symposium on Kallikreins, Lausanne, Switzerland, September 1-3 , 2005. Biol Chem. 2006;387:635-824 pubmed
  23. Zeng M, Zhang Y, Bhat I, Wazer D, Band H, Band V. The human kallikrein 10 promoter contains a functional retinoid response element. Biol Chem. 2006;387:741-7 pubmed
    Human kallikrein 10 (hK10) protein is expressed in normal breast but is significantly downregulated in a majority of invasive breast cancers. Thus, understanding how hK10 expression is regulated is of substantial significance...
  24. Paliouras M, Diamandis E. Intracellular signaling pathways regulate hormone-dependent kallikrein gene expression. Tumour Biol. 2008;29:63-75 pubmed publisher
    ..RT-PCR, Western blots and immunoprecipitations were used to assess transcript and protein levels. PSA, KLK10, KLK11, KLK13 and KLK14 are upregulated upon androgen stimulation in the T47D cell line...
  25. Yousef G, White N, Michael I, Cho J, Robb J, Kurlender L, et al. Identification of new splice variants and differential expression of the human kallikrein 10 gene, a candidate cancer biomarker. Tumour Biol. 2005;26:227-35 pubmed
    The human kallikrein gene 10 (KLK10) is a member of the kallikrein gene family on chromosome 19q13.4...
  26. Diamandis E, Yousef G, Luo L, Magklara A, Obiezu C. The new human kallikrein gene family: implications in carcinogenesis. Trends Endocrinol Metab. 2000;11:54-60 pubmed
    ..two to three years, new putative members of the human kallikrein gene family have been identified, including the PRSSL1 gene [encoding normal epithelial cell-specific 1 gene (NES1)], the gene encoding zyme/protease M/neurosin, the ..
  27. Schuster H, Peper J, Bösmüller H, Röhle K, Backert L, Bilich T, et al. The immunopeptidomic landscape of ovarian carcinomas. Proc Natl Acad Sci U S A. 2017;114:E9942-E9951 pubmed publisher
    ..of a variety of benign sources has unveiled a multitude of ovarian cancer antigens (MUC16, MSLN, LGALS1, IDO1, KLK10) to be presented by HLA class I and class II molecules exclusively on ovarian cancer cells...
  28. Geng X, Liu Y, Diersch S, Kotzsch M, Grill S, Weichert W, et al. Clinical relevance of kallikrein-related peptidase 9, 10, 11, and 15 mRNA expression in advanced high-grade serous ovarian cancer. PLoS ONE. 2017;12:e0186847 pubmed publisher
    ..Pronounced correlations between KLK10/KLK11 (rs = 0.647) and between KLK9/KLK15 (rs = 0...
  29. Santin A, Diamandis E, Bellone S, Marizzoni M, Bandiera E, Palmieri M, et al. Overexpression of kallikrein 10 (hK10) in uterine serous papillary carcinomas. Am J Obstet Gynecol. 2006;194:1296-302 pubmed
    b>Kallikrein 10 is a secreted serine protease recently implicated in the growth and invasion of several human tumors...
  30. Wang Z, Ruan B, Jin Y, Zhang Y, Li J, Zhu L, et al. Identification of KLK10 as a therapeutic target to reverse trastuzumab resistance in breast cancer. Oncotarget. 2016;7:79494-79502 pubmed publisher
    ..Among them, KLK10 was verified to be a potential therapeutic target for reversing trastuzumab resistance...
  31. Emami N, Scorilas A, Soosaipillai A, Earle T, Mullen B, Diamandis E. Association between kallikrein-related peptidases (KLKs) and macroscopic indicators of semen analysis: their relation to sperm motility. Biol Chem. 2009;390:921-9 pubmed publisher
    ..In conclusion, the expression level of several seminal plasma KLKs correlates with liquefaction and viscosity indicators of semen quality and may aid in their differential diagnosis and etiology. ..
  32. Ruckert F, Hennig M, Petraki C, Wehrum D, Distler M, Denz A, et al. Co-expression of KLK6 and KLK10 as prognostic factors for survival in pancreatic ductal adenocarcinoma. Br J Cancer. 2008;99:1484-92 pubmed publisher
    ..Previous studies suggested an upregulation of KLK10 and KLK6 in pancreatic ductal adenocarcinoma (PDAC)...
  33. Gan L, Lee I, Smith R, Argonza Barrett R, Lei H, McCuaig J, et al. Sequencing and expression analysis of the serine protease gene cluster located in chromosome 19q13 region. Gene. 2000;257:119-30 pubmed
    ..The proteases, excluding the kallikrein genes, share approximately 40% of their sequences suggesting that the serine protease gene cluster on chromosome 19q13 arose from ancient gene duplications. ..
  34. Zheng H, Zhang W, Wang X, Zhao G. [Enhancement of kallikrein-related peptidase 10 expression attenuates proliferation and invasiveness of human tongue cancer cells in vitro]. Nan Fang Yi Ke Da Xue Xue Bao. 2012;32:1796-9 pubmed
    To study the effect of kallikrein-related peptidase 10 (KLK10) on the proliferation and invasiveness of human tongue cancer cell line Tca8113...
  35. Rotondo F, Di Ieva A, Kovacs K, Cusimano M, Syro L, Diamandis E, et al. Human kallikrein 10 in surgically removed human pituitary adenomas. Hormones (Athens). 2015;14:272-9 pubmed publisher
    Human kallikrein-like peptidase 10 (KLK10), a serine protease, plays an important role in the regulation of cell proliferation and tumor growth...
  36. Darling M, Hashem N, Zhang I, Mohamed A, Fung K, Kwan K, et al. Kallikrein-related peptidase 10 expression in salivary gland tissues and tumours. Int J Biol Markers. 2012;27:e381-8 pubmed publisher
    Kallikrein-related peptidase 10 (KLK10) has been implicated in the development of several types of cancer. The purpose of this study was to analyze the expression of KLK10 in 3 types of salivary gland tumour and normal salivary glands.
  37. Talieri M, Alexopoulou D, Scorilas A, Kypraios D, Arnogiannaki N, Devetzi M, et al. Expression analysis and clinical evaluation of kallikrein-related peptidase 10 (KLK10) in colorectal cancer. Tumour Biol. 2011;32:737-44 pubmed publisher
    Kallikrein-related peptidases (KLKs) represent a serine protease family having 15 members. KLK10 is a secreted protease with a trypsin-like activity...
  38. Adamopoulos P, Kontos C, Scorilas A. Identification and molecular cloning of novel transcripts of the human kallikrein-related peptidase 10 (KLK10) gene using next-generation sequencing. Biochem Biophys Res Commun. 2017;487:776-781 pubmed publisher
    ..In this study, we describe the identification and molecular cloning of eight novel transcripts of the human KLK10 gene using 3' rapid amplification of cDNA ends (3' RACE) and next-generation sequencing (NGS), as well as their ..
  39. Kulasingam V, Diamandis E. Glucocorticoid receptor-mediated expression of kallikrein 10 in human breast cancer cell lines. Biol Chem. 2007;388:1113-9 pubmed
    ..lines MCF-10A, MDA-MB-468 and T-47D, we investigated the role of various glucocorticoids in regulating human kallikrein 10 expression...
  40. Pettus J, Johnson J, Shi Z, Davis J, Koblinski J, Ghosh S, et al. Multiple kallikrein (KLK 5, 7, 8, and 10) expression in squamous cell carcinoma of the oral cavity. Histol Histopathol. 2009;24:197-207 pubmed publisher
    ..Control experiments show lack of reactivity against KLK3 (prostate specific antigen). These results demonstrate that kallikreins 5, 7, 8, and 10 are abundantly expressed in human OSCC and may be implicated in malignant progression. ..
  41. Olkhov Mitsel E, van der Kwast T, Kron K, Ozcelik H, Briollais L, Massey C, et al. Quantitative DNA methylation analysis of genes coding for kallikrein-related peptidases 6 and 10 as biomarkers for prostate cancer. Epigenetics. 2012;7:1037-45 pubmed
    ..To assess the biological effect of DNA methylation on KLK6 and KLK10 expression, we treated PC3 and 22RV1 PCa cells with a demethylating drug, 5-aza-2'deoxycytidine, and observed ..
  42. Sauter E, Lininger J, Magklara A, Hewett J, Diamandis E. Association of kallikrein expression in nipple aspirate fluid with breast cancer risk. Int J Cancer. 2004;108:588-91 pubmed
    ..hK2 and PSA, and hK6 and hK10 are highly associated. Higher premenopausal PSA levels suggest the influence of ovarian steroids. PSA shows the most promise in aiding in the early detection of breast cancer. ..
  43. Diamandis E, Scorilas A, Kishi T, Blennow K, Luo L, Soosaipillai A, et al. Altered kallikrein 7 and 10 concentrations in cerebrospinal fluid of patients with Alzheimer's disease and frontotemporal dementia. Clin Biochem. 2004;37:230-7 pubmed
    ..The possible connection between these enzymes and the pathogenesis and progression of AD and FTD needs to be further investigated. ..
  44. Wang Y, Lin Y, Hung H, Tien W, Shieh T. Polymorphisms in Kallikrein7 and 10 genes and oral cancer risks in Taiwan betel quid chewers and smokers. Oral Dis. 2013;19:824-32 pubmed publisher
    We investigated the association between mRNA levels, polymorphisms of Kallikrein7 (KLK7) and Kallikrein10 (KLK10), and the development of oral squamous cell carcinoma (OSCC). We recruited 217 OSCC patients and 138 healthy controls...
  45. Klein R, Hallden C, Cronin A, Ploner A, Wiklund F, Bjartell A, et al. Blood biomarker levels to aid discovery of cancer-related single-nucleotide polymorphisms: kallikreins and prostate cancer. Cancer Prev Res (Phila). 2010;3:611-9 pubmed publisher
    ..874 versus 0.866), providing proof in principle to clinical application for our findings. ..
  46. Tang L, Long Z, Feng G, Guo X, Yu M. NES1/KLK10 promotes trastuzumab resistance via activation of PI3K/AKT signaling pathway in gastric cancer. J Cell Biochem. 2017;: pubmed publisher
    ..The normal epithelial cell-specific-1 (NES1) gene, also named as KLK10, is recognized as a potential therapeutic target for reversing trastuzumab resistance...
  47. Polikoff D, Kuo W, Cochran J, Wernick M, Kowbel D, Myambo K, et al. Assignment of protease, serine-like 1 (PRSSL1) to human chromosome 19q13 by in situ hybridization and radiation hybrid mapping. Cytogenet Cell Genet. 1997;79:147-8 pubmed
  48. Dhar S, Bhargava R, Yunes M, Li B, Goyal J, Naber S, et al. Analysis of normal epithelial cell specific-1 (NES1)/kallikrein 10 mRNA expression by in situ hybridization, a novel marker for breast cancer. Clin Cancer Res. 2001;7:3393-8 pubmed
    Normal epithelial cell specific-1 (NES1)/kallikrein 10 gene is expressed in normal mammary and prostate epithelial cells, but the expression of NES1 mRNA and protein is markedly reduced in established breast and prostate cancer cell ..
  49. Di Meo A, Rotondo F, Kovacs K, Cusimano M, Syro L, Di Ieva A, et al. Human kallikrein 10 expression in surgically removed human pituitary corticotroph adenomas: an immunohistochemical study. Appl Immunohistochem Mol Morphol. 2015;23:433-7 pubmed publisher
    Human kallikrein 10 (hk10), a secreted serine protease, was reported to function as a tumor suppressor. hK10 immunoexpression has been demonstrated in lactrotrophs and corticotrophs of the nontumorous human adenohypophysis...
  50. Jiao X, Lu H, Zhai M, Tan Z, Zhi H, Liu X, et al. Overexpression of kallikrein gene 10 is a biomarker for predicting poor prognosis in gastric cancer. World J Gastroenterol. 2013;19:9425-31 pubmed publisher
    To analyze the expression of kallikrein gene 10 (KLK10) in gastric cancer and to determine whether KLK10 has independent prognostic value in gastric cancer...
  51. Luo L, Diamandis E, Look M, Soosaipillai A, Foekens J. Higher expression of human kallikrein 10 in breast cancer tissue predicts tamoxifen resistance. Br J Cancer. 2002;86:1790-6 pubmed
    ..3-4. Human kallikrein 6 and human kallikrein 10 are two new members of this family...
  52. Planque C, Aïnciburu M, Heuzé Vourc h N, Regina S, De Monte M, Courty Y. Expression of the human kallikrein genes 10 (KLK10) and 11 (KLK11) in cancerous and non-cancerous lung tissues. Biol Chem. 2006;387:783-8 pubmed
    Only one transcript for KLK10 was identified by RT-PCR in lung tissue, whereas KLK11 expressed at least four alternative transcripts...
  53. Feng B, Xu W, Zheng M, Ma J, Cai Q, Zhang Y, et al. Clinical significance of human kallikrein 10 gene expression in colorectal cancer and gastric cancer. J Gastroenterol Hepatol. 2006;21:1596-603 pubmed
    Recent evidence suggests that the human kallikrein 10 (KLK10) gene is differentially regulated in endocrine-related tumors and has potential as diagnostic and/or prognostic marker; however, KLK10 expression has never been investigated in ..
  54. Pépin D, Shao Z, Huppé G, Wakefield A, Chu C, Sharif Z, et al. Kallikreins 5, 6 and 10 differentially alter pathophysiology and overall survival in an ovarian cancer xenograft model. PLoS ONE. 2011;6:e26075 pubmed publisher
    ..When compared to control mice, survival of mice injected with ES-2 clones overexpressing KLK10, 10/5, 10/6, 5/6 was significantly longer, while KLK6 was shorter...
  55. Batra J, Tan O, O Mara T, Zammit R, Nagle C, Clements J, et al. Kallikrein-related peptidase 10 (KLK10) expression and single nucleotide polymorphisms in ovarian cancer survival. Int J Gynecol Cancer. 2010;20:529-36 pubmed publisher
    Kallikrein-related peptidase 10 (KLK10) overexpression is a predictor of poor disease outcome in women with late-stage ovarian cancer...
  56. Paliouras M, Diamandis E. Androgens act synergistically to enhance estrogen-induced upregulation of human tissue kallikreins 10, 11, and 14 in breast cancer cells via a membrane bound androgen receptor. Mol Oncol. 2008;1:413-24 pubmed publisher
    ..to be sensitive to both, androgens (secreting PSA) and estrogens (secreting a number of kallikreins including KLK10, 11, and KLK14)...
  57. Filippou P, Farkona S, Brinc D, Yu Y, Prassas I, Diamandis E. Biochemical and functional characterization of the human tissue kallikrein 9. Biochem J. 2017;474:2417-2433 pubmed publisher
    ..Two potential KLK9 substrates [KLK10 and midkine (MDK)] were subjected to further validation...
  58. Harvey T, Hooper J, Myers S, Stephenson S, Ashworth L, Clements J. Tissue-specific expression patterns and fine mapping of the human kallikrein (KLK) locus on proximal 19q13.4. J Biol Chem. 2000;275:37397-406 pubmed
    ..In addition, like the rat, these genes are expressed at varying levels in a diverse range of tissues although they exhibit quite distinct patterns of expression. ..
  59. Bharaj B, Luo L, Jung K, Stephan C, Diamandis E. Identification of single nucleotide polymorphisms in the human kallikrein 10 (KLK10) gene and their association with prostate, breast, testicular, and ovarian cancers. Prostate. 2002;51:35-41 pubmed
    The KLK10 gene (also known as the normal epithelial cell-specific 1 gene) is a member of the expanded human kallikrein gene family...
  60. Sardana G, Diamandis E. The kallikrein family of proteins as urinary biomarkers for the detection of prostate cancer. Clin Biochem. 2009;42:1483-6 pubmed publisher
    ..We were unable to distinguish men with and without prostate cancer using multiple kallikreins as urinary biomarkers. These results highlight the difficulties in diagnosing prostate cancer via urine testing for soluble biomarkers. ..
  61. Lu C, Hsieh S, Lu Y, Wu C, Chen L, Lo S, et al. Aberrant DNA methylation profile and frequent methylation of KLK10 and OXGR1 genes in hepatocellular carcinoma. Genes Chromosomes Cancer. 2009;48:1057-68 pubmed publisher
    ..from the hypermethylated group were validated by combined bisulfite restriction analysis; two genes, human kallikrein 10 gene (KLK10) and oxoglutarate (alpha-ketoglutarate) receptor 1 gene (OXGR1), were further analyzed by ..
  62. Papageorgis P, Lambert A, Ozturk S, Gao F, Pan H, Manne U, et al. Smad signaling is required to maintain epigenetic silencing during breast cancer progression. Cancer Res. 2010;70:968-78 pubmed publisher
    ..overactive transforming growth factor beta (TGFbeta) signaling and loss of expression of the CDH1, CGN, CLDN4, and KLK10 genes as a result of hypermethylation of their corresponding promoter regions...
  63. Jimenez L, Sharma V, Condeelis J, Harris T, Ow T, Prystowsky M, et al. MicroRNA-375 Suppresses Extracellular Matrix Degradation and Invadopodial Activity in Head and Neck Squamous Cell Carcinoma. Arch Pathol Lab Med. 2015;139:1349-61 pubmed publisher
    ..MicroRNA-375 regulates invadopodia maturation and function potentially by suppressing the expression and secretion of proteases. ..
  64. Teo C, Casey P, Rasheed S. The GNA13-RhoA signaling axis suppresses expression of tumor protective Kallikreins. Cell Signal. 2016;28:1479-88 pubmed publisher
    ..of several members of the Kallikrein-related peptidases (KLK) gene family, namely KLK5, KLK6, KLK7, KLK8 and KLK10, in MCF-10a lines with enhanced GNA13 protein expression...
  65. Petraki C, Youssef Y, Dubinski W, Lichner Z, Scorilas A, Pasic M, et al. Evaluation and prognostic significance of human tissue kallikrein-related peptidase 10 (KLK10) in colorectal cancer. Tumour Biol. 2012;33:1209-14 pubmed publisher
    ..The aim of this study was to investigate the expression of human tissue kallikrein-related peptidase 10 (KLK10) by immunohistochemistry in CRC, to correlate this expression with various histopathological and clinical ..
  66. Alexopoulou D, Papadopoulos I, Scorilas A. Clinical significance of kallikrein-related peptidase (KLK10) mRNA expression in colorectal cancer. Clin Biochem. 2013;46:1453-61 pubmed publisher
    ..The human kallikrein-related peptidase 10 (KLK10) gene is a member of the human tissue kallikrein family...
  67. Kolin D, Sy K, Rotondo F, Bassily M, Kovacs K, Brezden Masley C, et al. Prognostic significance of human tissue kallikrein-related peptidases 6 and 10 in gastric cancer. Biol Chem. 2014;395:1087-93 pubmed publisher
    ..This study assessed the prognostic utility of human tissue kallikrein-like peptidases 6 and 10 (KLK6 and KLK10) and correlated their expression with histopathological and clinical parameters in gastric cancer...
  68. Hu J, Lei H, Fei X, Liang S, Xu H, Qin D, et al. NES1/KLK10 gene represses proliferation, enhances apoptosis and down-regulates glucose metabolism of PC3 prostate cancer cells. Sci Rep. 2015;5:17426 pubmed publisher
    The normal epithelial cell-specific-1 (NES1) gene, also named as KLK10, is recognised as a novel putative tumour suppressor in breast cancer, but few studies have focused on the function of KLK10 in human prostate cancer...
  69. Grin A, Samaan S, Tripathi M, Rotondo F, Kovacs K, Bassily M, et al. Evaluation of human tissue kallikrein-related peptidases 6 and 10 expression in early gastroesophageal adenocarcinoma. Hum Pathol. 2015;46:541-8 pubmed publisher
    ..In this study, we investigated kallikrein-related peptidase 6 (KLK6) and KLK10 expression in early gastroesophageal junction adenocarcinoma and Barrett esophagus (BE) with and without dysplasia...