KLF5

Summary

Gene Symbol: KLF5
Description: Kruppel like factor 5
Alias: BTEB2, CKLF, IKLF, Krueppel-like factor 5, (intestinal Kruppel-like factor, BTE-binding protein 2, GC box binding protein 2, Klf5C isoform, Kruppel-like factor 5 (intestinal), basic transcription element binding protein 2, colon krueppel-like factor, colon kruppel-like factor, intestinal-enriched krueppel-like factor, intestinal-enriched kruppel-like factor, transcription factor BTEB2
Species: human
Products:     KLF5

Top Publications

  1. Diakiw S, Kok C, To L, Lewis I, Brown A, D Andrea R. The granulocyte-associated transcription factor Krüppel-like factor 5 is silenced by hypermethylation in acute myeloid leukemia. Leuk Res. 2012;36:110-6 pubmed publisher
    Krüppel-like factor 5 (KLF5) has been implicated as a tumor suppressor in various solid tumors such as breast and prostate, and recent studies have demonstrated a role for this protein in neutrophil differentiation of acute promyelocytic ..
  2. Tong D, Czerwenka K, Heinze G, Ryffel M, Schuster E, Witt A, et al. Expression of KLF5 is a prognostic factor for disease-free survival and overall survival in patients with breast cancer. Clin Cancer Res. 2006;12:2442-8 pubmed
    Kruppel-like factor (KLF5) is a cell growth mediator in various epithelial cells. Higher KLF5 increases cell growth rate and leads to transformed phenotypes...
  3. Sur I, Undén A, Toftgard R. Human Krüppel-like factor5/KLF5: synergy with NF-kappaB/Rel factors and expression in human skin and hair follicles. Eur J Cell Biol. 2002;81:323-34 pubmed
    In this report we describe the identification of Krüppel-like factor 5 (KLF5/BTEB2) in a yeast one-hybrid screen using a keratinocyte-specific, NF-kappaB binding site as bait...
  4. Humbert M, Halter V, Shan D, Laedrach J, Leibundgut E, Baerlocher G, et al. Deregulated expression of Kruppel-like factors in acute myeloid leukemia. Leuk Res. 2011;35:909-13 pubmed publisher
    ..We found that KLF2, KLF3, KLF5 and KLF6 are significantly lower expressed in AML blast and CD34+ progenitor cells as compared to normal ..
  5. Chen C, Benjamin M, Sun X, Otto K, Guo P, Dong X, et al. KLF5 promotes cell proliferation and tumorigenesis through gene regulation and the TSU-Pr1 human bladder cancer cell line. Int J Cancer. 2006;118:1346-55 pubmed
    b>KLF5 is a transcription factor that plays important roles in multiple physical and pathological processes, including cell growth, cell cycle regulation, and angiogenesis...
  6. Nandan M, McConnell B, Ghaleb A, Bialkowska A, Sheng H, Shao J, et al. Krüppel-like factor 5 mediates cellular transformation during oncogenic KRAS-induced intestinal tumorigenesis. Gastroenterology. 2008;134:120-30 pubmed
    Krüppel-like factor 5 (KLF5) is a zinc finger-transcription factor that regulates cell proliferation. Oncogenic KRAS mutations are commonly found in colorectal cancers...
  7. Oishi Y, Manabe I, Tobe K, Tsushima K, Shindo T, Fujiu K, et al. Krüppel-like transcription factor KLF5 is a key regulator of adipocyte differentiation. Cell Metab. 2005;1:27-39 pubmed
    Krüppel-like factor 5 (KLF5) is a zinc-finger transcription factor known to play a pivotal role in the pathogenesis of cardiovascular disease...
  8. Chanchevalap S, Nandan M, McConnell B, Charrier L, Merlin D, Katz J, et al. Kruppel-like factor 5 is an important mediator for lipopolysaccharide-induced proinflammatory response in intestinal epithelial cells. Nucleic Acids Res. 2006;34:1216-23 pubmed
    ..We previously demonstrated that the Krüppel-like factor 5 [KLF5; also known as intestine-enriched Krüppel-like factor (IKLF)] is activated by the MAPK...
  9. Chen C, Bhalala H, Vessella R, Dong J. KLF5 is frequently deleted and down-regulated but rarely mutated in prostate cancer. Prostate. 2003;55:81-8 pubmed
    ..Mutations of KLF5 were detected by the approaches of single strand conformational polymorphism (SSCP) and direct sequencing...

More Information

Publications83

  1. Kumekawa M, Fukuda G, Shimizu S, Konno K, Odawara M. Inhibition of monocyte chemoattractant protein-1 by Krüppel-like factor 5 small interfering RNA in the tumor necrosis factor- alpha-activated human umbilical vein endothelial cells. Biol Pharm Bull. 2008;31:1609-13 pubmed
    Krüppel-like factor 5 (KLF5) is one of the pivotal transcriptional factors communicating with inflammatory cytokines...
  2. Liu R, Zheng H, Zhou Z, Dong J, Chen C. KLF5 promotes breast cell survival partially through fibroblast growth factor-binding protein 1-pERK-mediated dual specificity MKP-1 protein phosphorylation and stabilization. J Biol Chem. 2009;284:16791-8 pubmed publisher
    Krüpple-like transcription factor 5 (KLF5) is a zinc-finger transcription factor promoting cell survival and tumorigenesis in multiple cancers...
  3. Yang Y, Goldstein B, Chao H, Katz J. KLF4 and KLF5 regulate proliferation, apoptosis and invasion in esophageal cancer cells. Cancer Biol Ther. 2005;4:1216-21 pubmed
    KLF4 and KLF5, members of the KLF family of transcription factors, play key roles in proliferation, differentiation, and carcinogenesis in a number of gastrointestinal tissues...
  4. Shindo T, Manabe I, Fukushima Y, Tobe K, Aizawa K, Miyamoto S, et al. Krüppel-like zinc-finger transcription factor KLF5/BTEB2 is a target for angiotensin II signaling and an essential regulator of cardiovascular remodeling. Nat Med. 2002;8:856-63 pubmed
    We recently isolated a Krüppel-like zinc-finger transcription factor 5 (KLF5; also known as BTEB2 and IKLF), which is markedly induced in activated vascular smooth-muscle cells and fibroblasts...
  5. Nandan M, Yoon H, Zhao W, Ouko L, Chanchevalap S, Yang V. Krüppel-like factor 5 mediates the transforming activity of oncogenic H-Ras. Oncogene. 2004;23:3404-13 pubmed
    Previous studies indicate that Krüppel-like factor 5 (KLF5), also known as intestinal-enriched Krüppel-like factor (IKLF), is a positive regulator of cell proliferation and gives rise to a transformed phenotype when overexpressed...
  6. Sakamoto H, Sakamaki T, Kanda T, Hoshino Y, Sawada Y, Sato M, et al. Smooth muscle cell outgrowth from coronary atherectomy specimens in vitro is associated with less time to restenosis and expression of a key Transcription factor KLF5/BTEB2. Cardiology. 2003;100:80-5 pubmed
    ..We also examined expression of a Kruppel-like zinc-finger transcription factor 5 (KLF; also known as BTEB2 and IKLF), which is markedly induced in activated SMCs, in the same specimens...
  7. Fujiu K, Manabe I, Ishihara A, Oishi Y, Iwata H, Nishimura G, et al. Synthetic retinoid Am80 suppresses smooth muscle phenotypic modulation and in-stent neointima formation by inhibiting KLF5. Circ Res. 2005;97:1132-41 pubmed
    ..Am80, a synthetic retinoic acid receptor alpha-specific agonist, inhibits the activity of the transcription factor KLF5, which is essential for neointima formation after vascular injury...
  8. Mori A, Moser C, Lang S, Hackl C, Gottfried E, Kreutz M, et al. Up-regulation of Krüppel-like factor 5 in pancreatic cancer is promoted by interleukin-1beta signaling and hypoxia-inducible factor-1alpha. Mol Cancer Res. 2009;7:1390-8 pubmed publisher
    Krüppel-like factor 5 (KLF5) is a transcription factor involved in cell transformation, proliferation, and carcinogenesis that can be up-regulated by RAS mutations...
  9. Kojima S, Kobayashi A, Gotoh O, Ohkuma Y, Fujii Kuriyama Y, Sogawa K. Transcriptional activation domain of human BTEB2, a GC box-binding factor. J Biochem. 1997;121:389-96 pubmed
    b>BTEB2 is a GC box-binding transcription factor containing proline-rich and zinc finger domains as transactivation and DNA binding domains, respectively...
  10. Chanchevalap S, Nandan M, Merlin D, Yang V. All-trans retinoic acid inhibits proliferation of intestinal epithelial cells by inhibiting expression of the gene encoding Kruppel-like factor 5. FEBS Lett. 2004;578:99-105 pubmed
    ..Previous studies indicate that Kruppel-like factor 5 (KLF5) is a pro-proliferative transcription factor...
  11. McConnell B, Ghaleb A, Nandan M, Yang V. The diverse functions of Krüppel-like factors 4 and 5 in epithelial biology and pathobiology. Bioessays. 2007;29:549-57 pubmed
    ..KLF4 and KLF5 are two closely related members of this family and are both highly expressed in epithelial tissues...
  12. Kanazawa A, Kawamura Y, Sekine A, Iida A, Tsunoda T, Kashiwagi A, et al. Single nucleotide polymorphisms in the gene encoding Krüppel-like factor 7 are associated with type 2 diabetes. Diabetologia. 2005;48:1315-22 pubmed
    ..These results indicate that the gene encoding KLF7 is a novel candidate for conferring genetic susceptibility to type 2 diabetes. ..
  13. Conkright M, Wani M, Anderson K, Lingrel J. A gene encoding an intestinal-enriched member of the Krüppel-like factor family expressed in intestinal epithelial cells. Nucleic Acids Res. 1999;27:1263-70 pubmed
    ..member of the Krüppel-like family of transcription factors, named intestinal-enriched Krüppel-like factor (IKLF)...
  14. Aizawa K, Suzuki T, Kada N, Ishihara A, Kawai Kowase K, Matsumura T, et al. Regulation of platelet-derived growth factor-A chain by Krüppel-like factor 5: new pathway of cooperative activation with nuclear factor-kappaB. J Biol Chem. 2004;279:70-6 pubmed
    The transcription factor Krüppel-like factor 5 (KLF5) and its genetically downstream target gene platelet-derived growth factor-A (PDGF-A) chain are key factors in regulation of cardiovascular remodeling in response to stress...
  15. Zheng H, Zhou Z, Huang J, Chaudhury L, Dong J, Chen C. Krüppel-like factor 5 promotes breast cell proliferation partially through upregulating the transcription of fibroblast growth factor binding protein 1. Oncogene. 2009;28:3702-13 pubmed publisher
    The Krüppel-like factor 5 (KLF5) is a zinc-finger transcription factor promoting cell proliferation, cell-cycle progression and survival...
  16. Bateman N, Tan D, Pestell R, Black J, Black A. Intestinal tumor progression is associated with altered function of KLF5. J Biol Chem. 2004;279:12093-101 pubmed
    ..In the intestinal epithelium, expression of KLF5 (IKLF/BTEB2) is limited to proliferating crypt cells, indicating a growth-promoting role...
  17. Chen C, Bhalala H, Qiao H, Dong J. A possible tumor suppressor role of the KLF5 transcription factor in human breast cancer. Oncogene. 2002;21:6567-72 pubmed
    The 13q21 tumor suppressor locus, as defined by chromosomal deletion, harbors the KLF5 transcription factor which may have tumor suppressor function...
  18. Wan H, Luo F, Wert S, Zhang L, Xu Y, Ikegami M, et al. Kruppel-like factor 5 is required for perinatal lung morphogenesis and function. Development. 2008;135:2563-72 pubmed publisher
    ..In the present study, transgenic mice were generated in which the Kruppel-like factor 5 gene (Klf5) was conditionally deleted in respiratory epithelial cells in the fetal lung...
  19. Dong J, Chen C. Essential role of KLF5 transcription factor in cell proliferation and differentiation and its implications for human diseases. Cell Mol Life Sci. 2009;66:2691-706 pubmed publisher
    b>KLF5 (Kruppel-like factor 5) is a basic transcription factor binding to GC boxes at a number of gene promoters and regulating their transcription...
  20. He M, Han M, Zheng B, Shu Y, Wen J. Angiotensin II stimulates KLF5 phosphorylation and its interaction with c-Jun leading to suppression of p21 expression in vascular smooth muscle cells. J Biochem. 2009;146:683-91 pubmed publisher
    Krüppel-like factor 5 (KLF5) and c-Jun are involved in angiotensin II (Ang II)-induced cell proliferation and play an important role in p21 expression...
  21. Nandan M, Chanchevalap S, Dalton W, Yang V. Krüppel-like factor 5 promotes mitosis by activating the cyclin B1/Cdc2 complex during oncogenic Ras-mediated transformation. FEBS Lett. 2005;579:4757-62 pubmed
    We previously showed that the zinc finger-containing transcription factor Krüppel-like factor 5 (KLF5) is important in mediating transformation by oncogenic H-Ras through induction of cyclin D1 expression and acceleration of the G1/S ..
  22. Sun R, Chen X, Yang V. Intestinal-enriched Krüppel-like factor (Krüppel-like factor 5) is a positive regulator of cellular proliferation. J Biol Chem. 2001;276:6897-900 pubmed
    Intestinal-enriched Krüppel-like factor (IKLF or KLF5) belongs to the family of mammalian Krüppel-like transcription factors...
  23. Chen C, Zhou Y, Zhou Z, Sun X, Otto K, Uht R, et al. Regulation of KLF5 involves the Sp1 transcription factor in human epithelial cells. Gene. 2004;330:133-42 pubmed
    ..In the majority of cancer samples examined, a significant loss of expression for KLF5 has been detected...
  24. Liu R, Zhou Z, Zhao D, Chen C. The induction of KLF5 transcription factor by progesterone contributes to progesterone-induced breast cancer cell proliferation and dedifferentiation. Mol Endocrinol. 2011;25:1137-44 pubmed publisher
    ..In this study, we demonstrate that the mRNA and protein expression of Klf5, a pro-proliferation transcription factor in breast cancer, was dramatically up-regulated in mouse pregnant and ..
  25. Sogawa K, Imataka H, Yamasaki Y, Kusume H, Abe H, Fujii Kuriyama Y. cDNA cloning and transcriptional properties of a novel GC box-binding protein, BTEB2. Nucleic Acids Res. 1993;21:1527-32 pubmed
    We have cloned a cDNA for a novel GC box-binding protein designated BTEB2 from a human placenta cDNA library using rat BTEB cDNA (Imataka et al. (1992). EMBO J. 11,3663-3671. as a hybridization probe...
  26. Zhao D, Zhi X, Zhou Z, Chen C. TAZ antagonizes the WWP1-mediated KLF5 degradation and promotes breast cell proliferation and tumorigenesis. Carcinogenesis. 2012;33:59-67 pubmed publisher
    Krüppel-like factor 5 (KLF5) is a PY motif-containing transcription factor promoting breast cell proliferation...
  27. Ghaleb A, Nandan M, Chanchevalap S, Dalton W, Hisamuddin I, Yang V. Krüppel-like factors 4 and 5: the yin and yang regulators of cellular proliferation. Cell Res. 2005;15:92-6 pubmed
    ..KLF4 and KLF5 are two closely related members of the KLF family that have a similar tissue distribution in embryos and adults...
  28. Zhu N, Gu L, Findley H, Chen C, Dong J, Yang L, et al. KLF5 Interacts with p53 in regulating survivin expression in acute lymphoblastic leukemia. J Biol Chem. 2006;281:14711-8 pubmed
    The Kruppel-like factor 5 (KLF5) is a transcription factor that regulates cellular signaling involved in cell proliferation and oncogenesis...
  29. Nagai R, Suzuki T, Aizawa K, Shindo T, Manabe I. Significance of the transcription factor KLF5 in cardiovascular remodeling. J Thromb Haemost. 2005;3:1569-76 pubmed
    ..We previously isolated KLF5/basic transcription element-binding (BTEB)2, a Krüppel-like factor, as a transcription factor that binds the ..
  30. McConnell B, Bialkowska A, Nandan M, Ghaleb A, Gordon F, Yang V. Haploinsufficiency of Krüppel-like factor 5 rescues the tumor-initiating effect of the Apc(Min) mutation in the intestine. Cancer Res. 2009;69:4125-33 pubmed publisher
    ..Krüppel-like factor 5 (KLF5), a proproliferative transcription factor, is highly expressed in the proliferating intestinal crypt epithelial ..
  31. Ivy J, Drechsler M, Catterson J, Bodmer R, Ocorr K, Paululat A, et al. Klf15 Is Critical for the Development and Differentiation of Drosophila Nephrocytes. PLoS ONE. 2015;10:e0134620 pubmed publisher
    ..It was found that expression of Drosophila Klf15 (dKlf15, previously known as Bteb2) was restricted to the only two nephrocyte populations in Drosophila, the garland cells and pericardial ..
  32. Zhao T, Liu C, Chen L. Roles of Klf5 Acetylation in the Self-Renewal and the Differentiation of Mouse Embryonic Stem Cells. PLoS ONE. 2015;10:e0138168 pubmed publisher
    Transcription factor Krüppel-like factor 5 (Klf5) plays important roles in the formation of the inner cell mass (ICM) and the trophectoderm during embryogenesis, as well as the self-renewal and the differentiation of mouse embryonic ..
  33. Shain A, Salari K, Giacomini C, Pollack J. Integrative genomic and functional profiling of the pancreatic cancer genome. BMC Genomics. 2013;14:624 pubmed publisher
    ..functions of nucleoporin NUP153 (ostensibly by modulating TGFβ signaling) and Kruppel-like transcription factor KLF5 in pancreatic cancer...
  34. Zhang M, Zheng B, Tong F, Yang Z, Wang Z, Yang B, et al. iNOS-derived peroxynitrite mediates high glucose-induced inflammatory gene expression in vascular smooth muscle cells through promoting KLF5 expression and nitration. Biochim Biophys Acta Mol Basis Dis. 2017;1863:2821-2834 pubmed publisher
    ..Transcription factor KLF5 activates iNOS gene transcription and is involved in vascular inflammatory injury and remodeling...
  35. Frigo D, Sherk A, Wittmann B, Norris J, Wang Q, Joseph J, et al. Induction of Kruppel-like factor 5 expression by androgens results in increased CXCR4-dependent migration of prostate cancer cells in vitro. Mol Endocrinol. 2009;23:1385-96 pubmed publisher
    ..CXCR4 is not directly regulated by androgens but rather is positively up-regulated by Krüppel-like factor 5 (KLF5), a transcription factor that we have shown to be an early, direct target of AR...
  36. Nakajima Y, Osakabe A, Waku T, Suzuki T, Akaogi K, Fujimura T, et al. Estrogen Exhibits a Biphasic Effect on Prostate Tumor Growth through the Estrogen Receptor β-KLF5 Pathway. Mol Cell Biol. 2016;36:144-56 pubmed publisher
    ..by knockdown of either estrogen receptor β (ERβ) or Krüppel-like zinc finger transcription factor 5 (KLF5)...
  37. Chen C, Lin S, Lin Y, Lin S, Chen D, Chen C. Association of expression of kruppel-like factor 4 and kruppel-like factor 5 with the clinical manifestations of breast cancer. Pathol Oncol Res. 2012;18:161-8 pubmed publisher
    ..In this study, we investigated the correlation between KLF4 and KLF5 expression and the clinical manifestations of breast cancer by immunohistochemical analysis...
  38. Sato T, Kanda T, Iida T, Takahashi T, Kishi S, Hoshino Y. Immunohistochemical study of surgically excised choroidal neovascular membranes. J Int Med Res. 2003;31:402-6 pubmed
  39. Drosatos K, Pollak N, Pol C, Ntziachristos P, Willecke F, Valenti M, et al. Cardiac Myocyte KLF5 Regulates Ppara Expression and Cardiac Function. Circ Res. 2016;118:241-53 pubmed publisher
    ..Many of the transcriptional regulators of Ppara are unknown. To determine the role of Krüppel-like factor 5 (KLF5) in transcriptional regulation of Ppara...
  40. Zhang X, Choi P, FRANCIS J, Imielinski M, Watanabe H, Cherniack A, et al. Identification of focally amplified lineage-specific super-enhancers in human epithelial cancers. Nat Genet. 2016;48:176-82 pubmed publisher
    ..Copy number gains of noncoding regions harboring super-enhancers near KLF5, USP12, PARD6B and MYC are associated with overexpression of these cancer-related genes...
  41. Pattison J, Posternak V, Cole M. Transcription Factor KLF5 Binds a Cyclin E1 Polymorphic Intronic Enhancer to Confer Increased Bladder Cancer Risk. Mol Cancer Res. 2016;14:1078-1086 pubmed
    ..assays, a novel enhancer element was identified within the first intron of CCNE1 that binds Kruppel-like Factor 5 (KLF5), a known transcriptional activator in bladder cancer...
  42. Hammoud A, Kirstein N, Mournetas V, Darracq A, Broc S, Blanchard C, et al. Murine Embryonic Stem Cell Plasticity Is Regulated through Klf5 and Maintained by Metalloproteinase MMP1 and Hypoxia. PLoS ONE. 2016;11:e0146281 pubmed publisher
    ..By employing a LIF-dependent 'plasticity' test, that we set up, we show that Klf5, but not JunB is a key LIF effector...
  43. Yang Y, Tarapore R, Jarmel M, Tetreault M, Katz J. p53 mutation alters the effect of the esophageal tumor suppressor KLF5 on keratinocyte proliferation. Cell Cycle. 2012;11:4033-9 pubmed publisher
    Krüppel-like factor 5 (KLF5) is a key transcriptional regulator that is typically pro-proliferative in non-transformed epithelial cells but inhibits proliferation in transformed epithelial cells...
  44. Fujii Y, Yoshihashi K, Suzuki H, Tsutsumi S, Mutoh H, Maeda S, et al. CDX1 confers intestinal phenotype on gastric epithelial cells via induction of stemness-associated reprogramming factors SALL4 and KLF5. Proc Natl Acad Sci U S A. 2012;109:20584-9 pubmed publisher
    ..activated by CDX1 in gastric epithelial cells and identified stemness-associated reprogramming factors SALL4 and KLF5. Indeed, SALL4 and KLF5 were aberrantly expressed in the CDX1(+) intestinal metaplasia of the stomach in both ..
  45. Abjalimov I, Zinovyeva M, Nikolaev L, Kopantzeva M, Kopantzev E, Sverdlov E. Expression of transcription factor genes in cell lines corresponding to different stages of pancreatic cancer progression. Dokl Biochem Biophys. 2017;475:267-270 pubmed publisher
    ..best models of quasi-mesenchymal and epithelial, respectively, types of progression of the pancreatic ductal adenocarcinoma, according to the content of E-cadherin and vimentin and the expression of KLF5 and ZEB1 transcription factors.
  46. Suzuki S, Nozawa Y, Tsukamoto S, Kaneko T, Manabe I, Imai H, et al. CHD1 acts via the Hmgpi pathway to regulate mouse early embryogenesis. Development. 2015;142:2375-84 pubmed publisher
    ..Moreover, expression of Hmgpi and Klf5, which regulate Pou5f1, Nanog and Cdx2, was also significantly suppressed at zygotic gene activation (ZGA)...
  47. Guo P, Dong X, Zhao K, Sun X, Li Q, Dong J. Estrogen-induced interaction between KLF5 and estrogen receptor (ER) suppresses the function of ER in ER-positive breast cancer cells. Int J Cancer. 2010;126:81-9 pubmed publisher
    Kruppel-like factor 5 (KLF5) is implicated in human breast cancer by frequent genomic deletion and expressional deregulation, but the molecular mechanisms by which KLF5 affects breast tumorigenesis are still unknown...
  48. Zhao D, Zheng H, Zhou Z, Chen C. The Fbw7 tumor suppressor targets KLF5 for ubiquitin-mediated degradation and suppresses breast cell proliferation. Cancer Res. 2010;70:4728-38 pubmed publisher
    Fbw7 is a tumor suppressor frequently inactivated in cancers. The KLF5 transcription factor promotes breast cell proliferation and tumorigenesis through upregulating FGF-BP...
  49. Li X, He Y, Xu Y, Huang X, Liu J, Xie M, et al. KLF5 mediates vascular remodeling via HIF-1α in hypoxic pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol. 2016;310:L299-310 pubmed publisher
    Hypoxic pulmonary hypertension (HPH) is characterized by active vasoconstriction and profound vascular remodeling. KLF5, a zinc-finger transcription factor, is involved in the excessive proliferation and apoptotic resistance phenotype ..
  50. Oishi Y, Manabe I, Imai Y, Hara K, Horikoshi M, Fujiu K, et al. Regulatory polymorphism in transcription factor KLF5 at the MEF2 element alters the response to angiotensin II and is associated with human hypertension. FASEB J. 2010;24:1780-8 pubmed publisher
    Krüppel-like factor 5 (KLF5) is a zinc-finger-type transcription factor that mediates the tissue remodeling in cardiovascular diseases, such as atherosclerosis, restenosis, and cardiac hypertrophy...
  51. Yang W, Xu T, Qiu P, Xu G. Caveolin-1 promotes pituitary adenoma cells migration and invasion by regulating the interaction between EGR1 and KLF5. Exp Cell Res. 2018;367:7-14 pubmed publisher
    ..showed that cav-1 knockdown inhibited the nuclear translocation of EGR1, reducing the interaction between EGR1 and KLF5. The resulting free KLF5 promoted the expression of miR-145, miR-124 and miR-183 by binding to their promoters, ..
  52. Liu R, Dong J, Chen C. Role of KLF5 in hormonal signaling and breast cancer development. Vitam Horm. 2013;93:213-25 pubmed publisher
    ..Krüppel-like factor 5 (KLF5) is a transcription factor playing significant roles in breast carcinogenesis, whose expression has been shown to ..
  53. Chen B, Gao S, Ji C, Song G. Integrated analysis reveals candidate genes and transcription factors in lung adenocarcinoma. Mol Med Rep. 2017;16:8371-8379 pubmed publisher
    ..In conclusion, the present study provided for further studies a list of candidate genes and TFs for the detection and treatment of lung adenocarcinoma...
  54. Chen C, Sun X, Ran Q, Wilkinson K, Murphy T, Simons J, et al. Ubiquitin-proteasome degradation of KLF5 transcription factor in cancer and untransformed epithelial cells. Oncogene. 2005;24:3319-27 pubmed
    ..The Kruppel-like factor 5 (KLF5) transcription factor regulates biological processes involved in carcinogenesis, angiogenesis, and smooth muscle ..
  55. Zheng B, Yin W, Suzuki T, Zhang X, Zhang Y, Song L, et al. Exosome-Mediated miR-155 Transfer from Smooth Muscle Cells to Endothelial Cells Induces Endothelial Injury and Promotes Atherosclerosis. Mol Ther. 2017;25:1279-1294 pubmed publisher
    ..Here, we show that miR-155, which is significantly expressed and secreted in Krüppel-like factor 5 (KLF5)-overexpressing vascular smooth muscle cells (VSMCs), is a potent regulator of endothelium barrier function through ..
  56. Gao Y, Wu K, Chen Y, Zhou J, Du C, Shi Q, et al. Beyond proliferation: KLF5 promotes angiogenesis of bladder cancer through directly regulating VEGFA transcription. Oncotarget. 2015;6:43791-805 pubmed publisher
    Abundant evidence has demonstrated critical roles of KLF5 in regulating cell proliferation in various cancers, however, its additional roles in other aspects of cancer development remain to be further clarified...
  57. Noda S, Asano Y, Nishimura S, Taniguchi T, Fujiu K, Manabe I, et al. Simultaneous downregulation of KLF5 and Fli1 is a key feature underlying systemic sclerosis. Nat Commun. 2014;5:5797 pubmed publisher
    ..suppressed in SSc dermal fibroblasts, Friend leukaemia integration 1 (Fli1) and Krüppel-like factor 5 (KLF5)...
  58. Courboulin A, Tremblay V, Barrier M, Meloche J, Jacob M, Chapolard M, et al. Krüppel-like factor 5 contributes to pulmonary artery smooth muscle proliferation and resistance to apoptosis in human pulmonary arterial hypertension. Respir Res. 2011;12:128 pubmed publisher
    ..Krüppel-like factor 5 (KLF5), is a zinc-finger-type transcription factor implicated in the regulation of cell differentiation, proliferation, ..
  59. Zhang X, Zheng B, Yang Z, He M, Yue L, Zhang R, et al. TMEM16A and myocardin form a positive feedback loop that is disrupted by KLF5 during Ang II-induced vascular remodeling. Hypertension. 2015;66:412-21 pubmed publisher
    ..Angiotensin II inhibits TMEM16A expression via Krüppel-like factor 5 (KLF5) in cultured HASMCs...
  60. Guo L, He P, No Y, Yun C. Krüppel-like factor 5 incorporates into the β-catenin/TCF complex in response to LPA in colon cancer cells. Cell Signal. 2015;27:961-8 pubmed publisher
    ..LPA stimulates proliferation of colon cancer cells by activation of β-catenin or Krüppel-like factor 5 (KLF5), but the functional relationship between these two transcription factors is not clear...
  61. Soon M, Hsu L, Chen C, Chu P, Liou J, Lin S, et al. Expression of Kr?ppel-like factor 5 in gastric cancer and its clinical correlation in Taiwan. Virchows Arch. 2011;459:161-6 pubmed publisher
    ..Here, we investigated the expression of KLF5 in gastric cancers and its correlation with clinicopathological parameters and overall survival rates...
  62. Xie N, Chen M, Dai R, Zhang Y, Zhao H, Song Z, et al. SRSF1 promotes vascular smooth muscle cell proliferation through a Δ133p53/EGR1/KLF5 pathway. Nat Commun. 2017;8:16016 pubmed publisher
    ..133p53, which has an equal proliferative effect and in turn transcriptionally activates Krüppel-like factor 5 (KLF5) via the Δ133p53-EGR1 complex, resulting in an accelerated cell-cycle progression and increased VSMC proliferation...
  63. Li H, Miao S, Dong L, Shu Y, Shao D, Chen B, et al. Clinicopathological correlation of Krüppel-like factor 5 and matrix metalloproteinase-9 expression and cartilage degeneration in human osteoarthritis. Pathol Res Pract. 2012;208:9-14 pubmed publisher
    The present study was designed to investigate the clinicopathological correlation between the expression of KLF5 and MMP-9, which are associated with extracellular matrix degradation and cartilage degeneration in human knee osteoarthritis ..
  64. Ge F, Chen W, Qin J, Zhou Z, Liu R, Liu L, et al. Ataxin-3 like (ATXN3L), a member of the Josephin family of deubiquitinating enzymes, promotes breast cancer proliferation by deubiquitinating Krüppel-like factor 5 (KLF5). Oncotarget. 2015;6:21369-78 pubmed
    The Krüppel-like factor 5 (KLF5) has been suggested to promote breast cell proliferation, survival and tumorigenesis...
  65. Ma D, Zhang R, Wen Y, Yin W, Bai D, Zheng G, et al. 1, 25(OH)2D3-induced interaction of vitamin D receptor with p50 subunit of NF-?B suppresses the interaction between KLF5 and p50, contributing to inhibition of LPS-induced macrophage proliferation. Biochem Biophys Res Commun. 2017;482:366-374 pubmed publisher
    b>KLF5 and nuclear factor ?B (NF-?B) regulate cell proliferation and inflammation. Vitamin D signaling through vitamin D receptor (VDR) exerts anti-proliferative and anti-inflammatory actions...
  66. Chia N, Deng N, Das K, Huang D, Hu L, Zhu Y, et al. Regulatory crosstalk between lineage-survival oncogenes KLF5, GATA4 and GATA6 cooperatively promotes gastric cancer development. Gut. 2015;64:707-19 pubmed publisher
    ..Three transcription factors, KLF5, GATA4 and GATA6, have been previously reported to exhibit genomic amplification in GC...
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    b>KLF5 possesses both tumor suppressing and tumor promoting activities, though the mechanism controlling these opposing functions is unknown...
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    ..1 (2 times), NR5A2 (2.5 times), KLF5 (1.8 times), ZEB1 (3 times), and ONECUT1 (1...
  69. Dang D, Zhao W, Mahatan C, Geiman D, Yang V. Opposing effects of Krüppel-like factor 4 (gut-enriched Krüppel-like factor) and Krüppel-like factor 5 (intestinal-enriched Krüppel-like factor) on the promoter of the Krüppel-like factor 4 gene. Nucleic Acids Res. 2002;30:2736-41 pubmed
    ..Krüppel-like factor, GKLF) and KLF5 (Krüppel-like factor 5 or intestinal-enriched Krüppel-like factor, IKLF) are two closely related members of the zinc finger-containing Krüppel-like factor family of transcription factors...
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    ..Recently, we have shown that Krüppel-like factor KLF5, a member of the Sp/KLF family of zinc finger factors and a key regulator of cardiovascular remodeling, is ..
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    ..We investigated the role of the transcription factor Krüppel-like factor 5 (KLF5) in ADM and KRAS-mediated formation of PanINs...
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    The Kruppel-like factor 5 (KLF5) transcription factor is highly expressed in high-grade and basal-like breast cancers. However, the mechanism by which KLF5 promotes cell migration and invasion is still not completely understood...
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    Krüppel-like zinc-finger transcription factor 5 (KLF5), known as BTEB2 and IKLF, has several biological functions that involve cell proliferation, development, and apoptosis...