KLF11

Summary

Gene Symbol: KLF11
Description: Kruppel-like factor 11
Alias: FKLF, FKLF1, MODY7, TIEG2, Tieg3, Krueppel-like factor 11, TGFB-inducible early growth response protein 2, TIEG-2, transforming growth factor-beta-inducible early growth response protein 2
Species: human

Top Publications

  1. ncbi Dual functions of transcription factors, transforming growth factor-beta-inducible early gene (TIEG)2 and Sp3, are mediated by CACCC element and Sp1 sites of human monoamine oxidase (MAO) B gene
    Xiao Ming Ou
    Department of Molecular Pharmacology and Toxicology, School of Pharmacy, University of Southern California, 1985 Zonal Avenue, Los Angeles, CA 90033, USA
    J Biol Chem 279:21021-8. 2004
  2. ncbi The tumor suppressor KLF11 mediates a novel mechanism in transforming growth factor beta-induced growth inhibition that is inactivated in pancreatic cancer
    Anita Buck
    Department of Internal Medicine I, University of Ulm, Germany
    Mol Cancer Res 4:861-72. 2006
  3. doi Molecular pharmacological basis of the YiSui ShenXu Granule in beta-thalassemia therapy
    Chong Zhang
    Molecular Biology Laboratory of Guang anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, China
    J Ethnopharmacol 120:437-41. 2008
  4. pmc Disruption of a novel Kruppel-like transcription factor p300-regulated pathway for insulin biosynthesis revealed by studies of the c.-331 INS mutation found in neonatal diabetes mellitus
    Amelie Bonnefond
    CNRS UMR 8199, Lille Pasteur Institute, Lille Nord de France University, F 59800 Lille, France
    J Biol Chem 286:28414-24. 2011
  5. pmc Role of transcription factor KLF11 and its diabetes-associated gene variants in pancreatic beta cell function
    Bernadette Neve
    Centre National de la Recherche Scientifique, Unité Mixte de Recherche 8090, Institute Pasteur de Lille, F 59019 Lille, France
    Proc Natl Acad Sci U S A 102:4807-12. 2005
  6. pmc MODY7 gene, KLF11, is a novel p300-dependent regulator of Pdx-1 (MODY4) transcription in pancreatic islet beta cells
    Martin E Fernandez-Zapico
    Schulze Center for Novel Therapeutics, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Biol Chem 284:36482-90. 2009
  7. pmc A conserved alpha-helical motif mediates the interaction of Sp1-like transcriptional repressors with the corepressor mSin3A
    J S Zhang
    Gastroenterology Research Unit, Mayo Clinic, Rochester, Minnesota 55901, USA
    Mol Cell Biol 21:5041-9. 2001
  8. pmc Sequence-specific recruitment of heterochromatin protein 1 via interaction with Krüppel-like factor 11, a human transcription factor involved in tumor suppression and metabolic diseases
    Gwen Lomberk
    Department of Biochemistry and Molecular Biology, Laboratory of Epigenetics and Chromatin Dynamics, GIH Division, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Biol Chem 287:13026-39. 2012
  9. ncbi Molecular cloning and characterization of TIEG2 reveals a new subfamily of transforming growth factor-beta-inducible Sp1-like zinc finger-encoding genes involved in the regulation of cell growth
    T Cook
    Gastroenterology Research Unit, Saint Marys Hospital, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Biol Chem 273:25929-36. 1998
  10. pmc Distinct role of Kruppel-like factor 11 in the regulation of prostaglandin E2 biosynthesis
    Navtej S Buttar
    Division of Gastroenterology, Mayo Clinic, Rochester, Minnesota 55902, USA
    J Biol Chem 285:11433-44. 2010

Scientific Experts

  • Sheng Cao
  • Xiao Ming Ou
  • Gaurang S Daftary
  • Gwen A Lomberk
  • Björn Spittau
  • Barbara Renga
  • Volker Ellenrieder
  • Toshihito Tanahashi
  • Li Kwan Chang
  • Navtej S Buttar
  • David Emery
  • JOSE CARLOS FLOREZ
  • Chao Zhong Song
  • George Stamatoyannopoulos
  • Heather Murray
  • Raul Urrutia
  • Martin E Fernandez-Zapico
  • Raul A Urrutia
  • Malayannan Subramaniam
  • Bernadette Neve
  • Philippe Froguel
  • Angela Mathison
  • Seungmae Seo
  • Ayako Mitsuma
  • Ruth Gutierrez-Aguilar
  • Thomas C Spelsberg
  • Ke Jie Yin
  • Huabing Zhang
  • Wei Zhang
  • Christine J Jung
  • Wensheng Zhang
  • Marta Faryna
  • Nikolaos Perakakis
  • Matthew Grunewald
  • Jeremy Duncan
  • Shakevia Johnson
  • Juan Iovanna
  • Amelie Bonnefond
  • Steven A Johnsen
  • Ken ichi Yamamoto
  • Lei Jiang
  • Ping Yin
  • John R Hawse
  • Masato Miyake
  • Anna Potapova
  • Roland Stein
  • Hendrik Wermann
  • Eiji Kuroda
  • H Asano
  • Maryam Rakhshandehroo
  • Gabriele Gohla
  • Emmanuel Vaillant
  • Martine Vaxillaire
  • Chong Zhang
  • Lijun Ma
  • Timothy E Cullingford
  • R Gutierrez-Aguilar
  • X Niu
  • Z Wang
  • Yamina Benmezroua
  • Torben Hansen
  • Oluf Pedersen
  • Yasmin H Hamid
  • Anita Buck
  • Kerstin Krieglstein
  • C Anthony Blau
  • Ping Zhang
  • A Daisy Narayan
  • Ziyuan Wang
  • Bo Jiang
  • Xiao Yun Ma
  • Libin Jia
  • Ning Gong
  • Tainqing Zhu
  • Yongsheng Chang
  • Zhijian Cai
  • Min Li
  • Jing Guo
  • Jianli Wang
  • Min Yang
  • Fude Fang
  • Y Eugene Chen
  • Zhaoyuan Hui
  • Gabriel Velez
  • Wenqiang Cao
  • Xia Liu
  • Gregory Gores
  • Lian Shen
  • Shutian Zhang
  • Bin Zhu

Detail Information

Publications69

  1. ncbi Dual functions of transcription factors, transforming growth factor-beta-inducible early gene (TIEG)2 and Sp3, are mediated by CACCC element and Sp1 sites of human monoamine oxidase (MAO) B gene
    Xiao Ming Ou
    Department of Molecular Pharmacology and Toxicology, School of Pharmacy, University of Southern California, 1985 Zonal Avenue, Los Angeles, CA 90033, USA
    J Biol Chem 279:21021-8. 2004
    ..Mutation of the CACCC element increased the MAO B promoter activity, and cotransfection with TIEG2 further increased the promoter activity, suggesting that CACCC was a repressor element...
  2. ncbi The tumor suppressor KLF11 mediates a novel mechanism in transforming growth factor beta-induced growth inhibition that is inactivated in pancreatic cancer
    Anita Buck
    Department of Internal Medicine I, University of Ulm, Germany
    Mol Cancer Res 4:861-72. 2006
    ..Here, we assessed the role of the repressor, KLF11, in TGFbeta-induced growth inhibition in normal epithelial as well as pancreatic carcinoma cells...
  3. doi Molecular pharmacological basis of the YiSui ShenXu Granule in beta-thalassemia therapy
    Chong Zhang
    Molecular Biology Laboratory of Guang anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, China
    J Ethnopharmacol 120:437-41. 2008
    ..To study the molecular pharmacological basis of the YiSui ShenXu Granule, a complex prescription of the Chinese traditional medicine used to treat beta-thalassemia...
  4. pmc Disruption of a novel Kruppel-like transcription factor p300-regulated pathway for insulin biosynthesis revealed by studies of the c.-331 INS mutation found in neonatal diabetes mellitus
    Amelie Bonnefond
    CNRS UMR 8199, Lille Pasteur Institute, Lille Nord de France University, F 59800 Lille, France
    J Biol Chem 286:28414-24. 2011
    ..reporter experiments, and chromatin immunoprecipitation demonstrates that, among 16 different KLF proteins tested, KLF11 is the most reliable activator of this site. Congruently, the c...
  5. pmc Role of transcription factor KLF11 and its diabetes-associated gene variants in pancreatic beta cell function
    Bernadette Neve
    Centre National de la Recherche Scientifique, Unité Mixte de Recherche 8090, Institute Pasteur de Lille, F 59019 Lille, France
    Proc Natl Acad Sci U S A 102:4807-12. 2005
    KLF11 (TIEG2) is a pancreas-enriched transcription factor that has elicited significant attention because of its role as negative regulator of exocrine cell growth in vitro and in vivo...
  6. pmc MODY7 gene, KLF11, is a novel p300-dependent regulator of Pdx-1 (MODY4) transcription in pancreatic islet beta cells
    Martin E Fernandez-Zapico
    Schulze Center for Novel Therapeutics, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Biol Chem 284:36482-90. 2009
    ..SP/Krüppel-like (SP/KLF) transcription factor, mutated in French maturity onset diabetes of the young patients (MODY7), regulates Pdx-1 transcription in beta cells through two evolutionarily conserved GC-rich motifs in conserved ..
  7. pmc A conserved alpha-helical motif mediates the interaction of Sp1-like transcriptional repressors with the corepressor mSin3A
    J S Zhang
    Gastroenterology Research Unit, Mayo Clinic, Rochester, Minnesota 55901, USA
    Mol Cell Biol 21:5041-9. 2001
    ..Here we report that TIEG2, a transforming growth factor beta-inducible Sp1-like protein with antiproliferative functions, represses ..
  8. pmc Sequence-specific recruitment of heterochromatin protein 1 via interaction with Krüppel-like factor 11, a human transcription factor involved in tumor suppression and metabolic diseases
    Gwen Lomberk
    Department of Biochemistry and Molecular Biology, Laboratory of Epigenetics and Chromatin Dynamics, GIH Division, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Biol Chem 287:13026-39. 2012
    ..A PXVXL HP1-interacting domain identified at position 487-491 of KLF11 mediates the binding of HP1α and KLF11 in vitro and in cultured cells...
  9. ncbi Molecular cloning and characterization of TIEG2 reveals a new subfamily of transforming growth factor-beta-inducible Sp1-like zinc finger-encoding genes involved in the regulation of cell growth
    T Cook
    Gastroenterology Research Unit, Saint Marys Hospital, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Biol Chem 273:25929-36. 1998
    ..nuclear localization, DNA binding activity, transcriptional repression activity, and growth inhibitory effects of TIEG2, a novel TGF-beta-inducible gene related to TIEG...
  10. pmc Distinct role of Kruppel-like factor 11 in the regulation of prostaglandin E2 biosynthesis
    Navtej S Buttar
    Division of Gastroenterology, Mayo Clinic, Rochester, Minnesota 55902, USA
    J Biol Chem 285:11433-44. 2010
    ..in this study a comprehensive investigation at the cellular, biochemical, and molecular levels reveal that KLF11 inhibits prostaglandin E(2) synthesis via transcriptional silencing of the promoter of its biosynthetic enzyme, ..
  11. doi Transcriptional regulation of a brown adipocyte-specific gene, UCP1, by KLF11 and KLF15
    Ken ichi Yamamoto
    Department of Cell Biology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700 8558, Japan
    Biochem Biophys Res Commun 400:175-80. 2010
    ..In this study, we focused on KLF11 and KLF15, which were expressed highly in brown adipose tissue...
  12. pmc Mechanistic role for a novel glucocorticoid-KLF11 (TIEG2) protein pathway in stress-induced monoamine oxidase A expression
    Matthew Grunewald
    Department of Psychiatry and Human Behavior, University of Mississippi Medical Center, Jackson, Mississippi 39216, USA
    J Biol Chem 287:24195-206. 2012
    ..relationship between stress-induced MAO A and the transcription factor Kruppel-like factor 11 (KLF11, also called TIEG2, a member of the Sp/KLF- family), which inhibits cell growth...
  13. doi Epigenetic inactivation of tumour suppressor gene KLF11 in myelodysplastic syndromes*
    Anna Potapova
    Institute of Pathology, Medizinische Hochschule Hannover, Hannover, Germany
    Eur J Haematol 84:298-303. 2010
    ..We therefore investigated the methylation status of transcription factor genes KLF5, KLF11, and MAFB, shown to be aberrantly methylated in myelogeneous leukaemia cells, in a series of 115 MDS patient as ..
  14. pmc Krüppel-like factor 11 differentially couples to histone acetyltransferase and histone methyltransferase chromatin remodeling pathways to transcriptionally regulate dopamine D2 receptor in neuronal cells
    Seungmae Seo
    Mayo Graduate School, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Biol Chem 287:12723-35. 2012
    ..we report the characterization of two antagonistic, chromatin-mediated mechanisms by which KLF11, also known as TIEG2 (transforming growth factor-β-inducible early gene 2) and MODY VII (maturity onset diabetes of the young VII), ..
  15. ncbi KLF11 mediates a critical mechanism in TGF-beta signaling that is inactivated by Erk-MAPK in pancreatic cancer cells
    Volker Ellenrieder
    Department of Internal Medicine, University of Ulm, Germany
    Gastroenterology 127:607-20. 2004
    ..Like the Smads, KLF11 is an early response transcription factor that mediates TGF-beta-induced growth inhibition in untransformed ..
  16. doi Genetic analysis of Kruppel-like zinc finger 11 variants in 5864 Danish individuals: potential effect on insulin resistance and modified signal transducer and activator of transcription-3 binding by promoter variant -1659G>C
    Ruth Gutierrez-Aguilar
    Centre National de la Recherche Scientifique Unit Mixte de Recherche 8090 Institute of Biology, Lille, France
    J Clin Endocrinol Metab 93:3128-35. 2008
    The transcription factor Krüppel-like zinc finger 11 (KLF11) has been suggested to contribute to genetic risk of type 2 diabetes (T2D)...
  17. ncbi KLF11-mediated repression antagonizes Sp1/sterol-responsive element-binding protein-induced transcriptional activation of caveolin-1 in response to cholesterol signaling
    Sheng Cao
    Gastroenterology Research Unit and Tumor Biology Program, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    J Biol Chem 280:1901-10. 2005
    ..describe a novel pathway distinct from the prototypical SREBP/Sp1 regulatory loop involving the Sp1-like protein, KLF11. Through a combination of RNA interference, chromatin immunoprecipitation assays, electrophoretic mobility shift ..
  18. ncbi The Krüppel-like factor 11 (KLF11) Q62R polymorphism is not associated with type 2 diabetes in 8,676 people
    Jose C Florez
    Simches Research Building, CPZN 6820, Diabetes Unit Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA 02114, USA
    Diabetes 55:3620-4. 2006
    ..A common glutamine-to-arginine change at codon 62 (Q62R) in its gene KLF11 has been recently associated with type 2 diabetes in two independent samples...
  19. pmc A novel role of the Sp/KLF transcription factor KLF11 in arresting progression of endometriosis
    Gaurang S Daftary
    Laboratory of Translational Epigenetics in Reproduction, Department of Obstetrics and Gynecology, Mayo Clinic, Rochester, MN, USA
    PLoS ONE 8:e60165. 2013
    ..In this study, we evaluated the role of the Sp/KLF transcription factor KLF11/Klf11 in the pathogenesis of endometriosis...
  20. doi Human Krüppel-like factor 11 differentially regulates human insulin promoter activity in β-cells and non-β-cells via p300 and PDX1 through the regulatory sites A3 and CACCC box
    Nikolaos Perakakis
    Division of Endocrinology and Diabetology, Department of Internal Medicine II, University Hospital of Freiburg, Hugstetter Strasse 55, 79106 Freiburg, Germany
    Mol Cell Endocrinol 363:20-6. 2012
    ..Since KLF11 is capable to differentially regulate genes dependent on recruited cofactors, we investigated the effects of ..
  21. pmc Krüppel-like factor 11 regulates the expression of metabolic genes via an evolutionarily conserved protein interaction domain functionally disrupted in maturity onset diabetes of the young
    Gwen Lomberk
    Laboratory of Epigenetics and Chromatin Dynamics, Epigenomics Translational Program, Mayo Clinic Center for Individualized Medicine, Division of Gastroenterology and Hepatology, and Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Biol Chem 288:17745-58. 2013
    ..Alterations in KLF11 function result in maturity onset diabetes of the young 7 (MODY7) and neonatal diabetes; however, the mechanisms underlying the role of this protein in metabolic disorders remain ..
  22. pmc KLF11 mediates PPARγ cerebrovascular protection in ischaemic stroke
    Ke Jie Yin
    Cardiovascular Centre, Department of Internal Medicine, University of Michigan Medical Centre, NCRC Bld 26, Rm 361S, 2800 Plymouth Rd, Ann Arbor, MI 48109, USA
    Brain 136:1274-87. 2013
    ..we screened for (PPARγ) co-regulators using a genome-wide and high-throughput co-activation system and revealed KLF11 as a novel (PPARγ) co-regulator, which interacted with (PPARγ) and regulated its function in mouse cerebral ..
  23. doi Mouse KLF11 regulates hepatic lipid metabolism
    Huabing Zhang
    National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
    J Hepatol 58:763-70. 2013
    Missense mutations in human Krüppel-like factor 11 (KLF11) lead to the development of diabetes, as a result of impaired insulin synthesis in the pancreas. However, the role of KLF11 in peripheral tissues is largely unknown...
  24. pmc Klf10 inhibits IL-12p40 production in macrophage colony-stimulating factor-induced mouse bone marrow-derived macrophages
    Wei Zhang
    Institute of Immunology, Zhejiang University School of Medicine, Hangzhou, China
    Eur J Immunol 43:258-69. 2013
    ..b>Klf11, another member of the Krüppel-like factor family, can also repress the production of IL-12p40...
  25. doi Genome-wide methylation screen in low-grade breast cancer identifies novel epigenetically altered genes as potential biomarkers for tumor diagnosis
    Marta Faryna
    German Cancer Research Center DKFZ, Division of Epigenomics and Cancer Risk Factors, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    FASEB J 26:4937-50. 2012
    ..In tumors, median methylation levels of BCAN, HOXD1, KCTD8, KLF11, NXPH1, POU4F1, SIM1, and TCF7L1 were ≥30% higher than in normal samples, representing potential biomarkers for ..
  26. pmc Role for Krüppel-like transcription factor 11 in mesenchymal cell function and fibrosis
    Angela Mathison
    Laboratory of Epigenetics and Chromatin Dynamics, Mayo Clinic, Rochester, Minnesota, United States of America Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota, United States of America
    PLoS ONE 8:e75311. 2013
    Krüppel-like factor 11 (KLF11) and the highly homologous KLF10 proteins are transcription factors originating from duplication of the Drosophila melanogaster ancestor cabut...
  27. ncbi Monoamine oxidases in major depressive disorder and alcoholism
    Jeremy Duncan
    Department of Psychiatry and Human Behavior, University of Mississippi Medical Center, Jackson, MS 39216, USA
    Drug Discov Ther 6:112-22. 2012
    ..KLF11 (a Krüppel-like factor; also referred to as transforming growth factor-beta early inducible gene 2, TIEG2), for both MAO-A and MAO-B, by binding to Sp/KLF sites in the core promoters of MAO and regulating MAO gene ..
  28. doi Human ESC self-renewal promoting microRNAs induce epithelial-mesenchymal transition in hepatocytes by controlling the PTEN and TGFβ tumor suppressor signaling pathways
    Christine J Jung
    Transplant Research Program and UC Davis Institute for Regenerative Cures, University of California Davis, Sacramento, CA 95817, USA
    Mol Cancer Res 10:979-91. 2012
    ..Proliferation in hepatocytes is mediated through translational repression of Pten, Tgfbr2, Klf11, and Cdkn1a, which collectively dysregulates the PI3K/AKT/mTOR and TGFβ tumor suppressor signaling pathways...
  29. pmc miRNA-mediated relationships between Cis-SNP genotypes and transcript intensities in lymphocyte cell lines
    Wensheng Zhang
    Department of Computer Science, Xavier University of Louisiana, New Orleans, Louisiana, United States of America
    PLoS ONE 7:e31429. 2012
    ..Among the cognate genes, six including ALG8, DGKE, GNA12, KLF11, LRPAP1, and MMAB are related to multiple genetic diseases such as depressive disorder and Type-II diabetes...
  30. ncbi Growth inhibitory signalling by TGFbeta is blocked in Ras-transformed intestinal epithelial cells at a post-receptor locus
    Bo Jiang
    Department of Pediatrics, Children s Hospital and The Ohio State University, Columbus, OH 43205, USA
    Cell Signal 15:699-708. 2003
    ..Nuclear translocation of Smad2 and Smad4 occurred equally in RIE-Ras and parental RIE cells. The activity of TIEG2, a TGFbeta-inducible SP1-like transcription factor, was reduced in RIE-Ras cells, implying that resistance in Ras-..
  31. ncbi [Functional importance of FKLF-2 in erythroid cell development]
    Ayako Mitsuma
    Rinsho Ketsueki 44:70-5. 2003
  32. ncbi [Transcriptional regulation of gamma- and epsilon-globin genes by basic Krüppel-like factor]
    Xiao Yun Ma
    Beijing Institute of Radiation Medicine, Beijing 100850, China
    Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (Shanghai) 35:271-6. 2003
    ..The stimulatory function of FKLF on gamma- and epsilon-globin gene promoters was also significantly reduced by hBKLF...
  33. doi Klf10 and Klf11 as mediators of TGF-beta superfamily signaling
    Björn Spittau
    Institute for Anatomy and Cell Biology, Department of Molecular Embryology, Albert Ludwigs University Freiburg, Albertstrasse 17, 79104 Freiburg, Germany
    Cell Tissue Res 347:65-72. 2012
    Klf10 and Klf11 belong to the family of Sp1/Krüppel-like zinc finger transcription factors that play important roles in a variety of cell types and tissues...
  34. doi Role of Penaeus monodon Kruppel-like factor (PmKLF) in infection by white spot syndrome virus
    Li Kwan Chang
    Department of Biochemical Science and Technology, National Taiwan University, Taipei 106, Taiwan, ROC
    Dev Comp Immunol 36:121-9. 2012
    ..Sequence analysis revealed that the sequence of PmKLF is similar to that of KLF11 in humans, mice and zebrafish. RT-PCR analysis indicated that PmKLF mRNA is expressed in all examined tissues...
  35. ncbi The effect of hypoxia and stem cell source on haemoglobin switching
    A Daisy Narayan
    Department of Animal Biotechnology, University of Nevada, Reno, NV 89557, USA
    Br J Haematol 128:562-70. 2005
    ..mRNA expression for the transcription factors erythroid Kruppel-like factor (EKLF) and fetal Kruppel-like factor (FKLF) as a function of time in cultures under hypoxia and normoxia...
  36. pmc Transcriptional regulation of FKLF-2 (KLF13) gene in erythroid cells
    Ayako Mitsuma
    Department of Hematology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Biochim Biophys Acta 1727:125-33. 2005
    b>FKLF-2 (KLF13) was cloned from fetal globin-expressing tissues and has been shown to be abundantly expressed in erythroid cells. In this study we examined the transcriptional regulation of the KLF13 gene. A 5...
  37. pmc A functional family-wide screening of SP/KLF proteins identifies a subset of suppressors of KRAS-mediated cell growth
    Martin E Fernandez-Zapico
    Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Rochester, MN 55901, USA
    Biochem J 435:529-37. 2011
    ..a comprehensive family-wide screening of the 24 SP/KLF members, we discovered that SP5, SP8, KLF2, KLF3, KLF4, KLF11, KLF13, KLF14, KLF15 and KLF16 inhibit cellular growth and suppress transformation mediated by oncogenic KRAS...
  38. ncbi A functional screen for Krüppel-like factors that regulate the human gamma-globin gene through the CACCC promoter element
    Ping Zhang
    Department of Human Genetics, Virginia Commonwealth University, PO Box 980033, 1101 E Marshall Street, Richmond, VA 23298 0033, USA
    Blood Cells Mol Dis 35:227-35. 2005
    ..KLF2/LKLF, KLF3/BKLF, KLF4/GKLF, KLF5/IKLF, KLF8/BKLF3, KLF11/FKLF, KLF12/AP-2rep and KLF13/FKLF2 were chosen for functional screening...
  39. doi Global DNA methylation in fetal human germ cells and germ cell tumours: association with differentiation and cisplatin resistance
    Hendrik Wermann
    Department of Pathology, Erasmus MC Erasmus University Medical Center, Daniel den Hoed Cancer Center, Josephine Nefkens Institute, Rotterdam, The Netherlands
    J Pathol 221:433-42. 2010
    ..Among the genes revealing changes, interesting targets were identified: ie demethylation of KLF11, a putative tumour suppressor gene, and hypermethylation of CFLAR, a gene previously described in treatment ..
  40. pmc Functional study of transcription factor KLF11 by targeted gene inactivation
    Chao Zhong Song
    Department of Medicine, Division of Medical Genetics, University of Washington, Seattle, WA 98195, USA
    Blood Cells Mol Dis 34:53-9. 2005
    ..b>KLF11 has been implicated in the regulation of cell growth and gene expression...
  41. ncbi Gene structure and evolution of Tieg3, a new member of the Tieg family of proteins
    Ziyuan Wang
    Center of Anatomy, Department of Neuroanatomy, University of Goettingen, Kreuzbergring 36, 37075 Goettingen, Germany
    Gene 325:25-34. 2004
    ..So far, Tieg1 and Tieg2 have been identified in human and mouse...
  42. pmc An mSin3A interaction domain links the transcriptional activity of KLF11 with its role in growth regulation
    Martin E Fernandez-Zapico
    Gastroenterology Research Unit, Saint Mary s Hospital, Mayo Clinic, Rochester, MN 55905, USA
    EMBO J 22:4748-58. 2003
    b>KLF11 is a biochemical paradigm for a subset of proteins that repress transcription via a Mad1-like mSin3A interacting domain (SID)...
  43. pmc Association analysis of Krüppel-like factor 11 variants with type 2 diabetes in Pima Indians
    Lijun Ma
    Diabetes Molecular Genetics Section, Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes, Digestive and Kidney Diseases, NIH, Phoenix, Arizona 85004, USA
    J Clin Endocrinol Metab 93:3644-9. 2008
    Krüppel-like factor 11 (KLF11) is a transcription factor of the zinc finger domain family that has been shown to regulate expression of the insulin gene...
  44. ncbi Modulation of transforming growth factor beta (TGFbeta)/Smad transcriptional responses through targeted degradation of TGFbeta-inducible early gene-1 by human seven in absentia homologue
    Steven A Johnsen
    Department of Biochemistry and Molecular Biology, Mayo Clinic and Foundation, 200 First Street SW, Rochester, MN 55905, USA
    J Biol Chem 277:30754-9. 2002
    ..Co-expression of SIAH1 results in proteasomal degradation of TIEG1 but not of the related factor TIEG2. Importantly, co-expression of SIAH1 completely reverses repression of Smad7 promoter activity by TIEG1...
  45. pmc Signaling disrupts mSin3A binding to the Mad1-like Sin3-interacting domain of TIEG2, an Sp1-like repressor
    Volker Ellenrieder
    Gastroenterology Research Unit, Mayo Clinic, Rochester, MN 55905, USA
    EMBO J 21:2451-60. 2002
    ..a structurally and functionally related Mad1-like SID is also present in five Sp1-like repressor proteins (TIEG1, TIEG2, BTEB1, BTEB3 and BTEB4), demonstrating that SID-mSin3A interactions have a wider functional impact on ..
  46. ncbi Identification of KLF13 and KLF14 (SP6), novel members of the SP/XKLF transcription factor family
    S Scohy
    Universite Libre de Bruxelles, IBMM, Rue Professeurs Jeener and Brachet, 12, Gosselies, B 6041, Belgium
    Genomics 70:93-101. 2000
    ..of this family was also identified in a human EST database; this sequence was found to be identical to KLF11 (TIEG2), recently identified by Cook et al. (1998, J. Biol. Chem. 273: 25929-25936)...
  47. ncbi FKLF-2: a novel Krüppel-like transcriptional factor that activates globin and other erythroid lineage genes
    H Asano
    Division of Medical Genetics, University of Washington, Seattle, WA 98195, USA
    Blood 95:3578-84. 2000
    b>FKLF-2, a novel Krüppel-type zinc finger protein, was cloned from murine yolk sac...
  48. pmc FKLF, a novel Krüppel-like factor that activates human embryonic and fetal beta-like globin genes
    H Asano
    Division of Medical Genetics, University of Washington, Seattle, Washington, USA
    Mol Cell Biol 19:3571-9. 1999
    A cDNA encoding a novel Krüppel-type zinc finger protein, FKLF, was cloned from fetal globin-expressing human fetal erythroid cells...
  49. pmc Ethanol increases TIEG2-MAO B cell death cascade in the prefrontal cortex of ethanol-preferring rats
    Xiao Ming Ou
    Division of Neurobiology and Behavioral Research, Department of Psychiatry and Human Behavior, University of Mississippi Medical Center, 2500 N State Street, Jackson, MS 39216, USA
    Neurotox Res 19:511-8. 2011
    ..GAPDH interacts with the transcriptional activator, transforming growth factor-beta-inducible early gene 2 (TIEG2), to augment TIEG2-mediated MAO B activation, resulting in neuronal cell damage due to ethanol exposure...
  50. doi Dynamic transcriptional changes of TIEG1 and TIEG2 during mouse tissue development
    Lei Jiang
    Institute of Cell Biology, Zhejiang University, Hangzhou, People s Republic of China
    Anat Rec (Hoboken) 293:858-64. 2010
    ..In this study, we aimed to investigate the transcriptional level of both TIEG1 and TIEG2 during development in various mice organs, including the brain cortex, cerebellum and stem, brain striatum, muscle,..
  51. ncbi TGFbeta regulated gene expression by Smads and Sp1/KLF-like transcription factors in cancer
    Volker Ellenrieder
    Signal Transduction Laboratory, Internal Medicine, Department of Gastroenterology and Endocrinology, University of Marburg, Marburg, Germany
    Anticancer Res 28:1531-9. 2008
    ..of a novel family of TGFbeta-inducible Sp1/KLF-(Krüppel-like factors) like transcription factors (KLF10 and KLF11) which play remarkable roles in TGFbeta mediated cell growth control and differentiation...
  52. ncbi Human TIEG2/KLF11 induces oligodendroglial cell death by downregulation of Bcl-XL expression
    Z Wang
    Center of Anatomy, Department of Neuroanatomy, University of Goettingen, Goettingen, Germany
    J Neural Transm 114:867-75. 2007
    ..b>TIEG2/KLF11 is a recently identified human TGF-beta-inducible zinc finger protein belonging to the family of Sp1/KLF-..
  53. ncbi Human Krüppel-like factor 11 inhibits human proinsulin promoter activity in pancreatic beta cells
    X Niu
    Laboratory B9, Division of Endocrinology and Diabetology, Department of Internal Medicine II, University Hospital of Freiburg, 79106, Freiburg, Germany
    Diabetologia 50:1433-41. 2007
    The Krüppel-like factor 11 (KLF11; TIEG2), a pancreas-enriched Sp1-like transcription factor, is a known negative regulator of pancreatic exocrine cell growth...
  54. pmc Differential regulation of Krüppel-like factor family transcription factor expression in neonatal rat cardiac myocytes: effects of endothelin-1, oxidative stress and cytokines
    Timothy E Cullingford
    National Heart and Lung Institute NHLI Division, Faculty of Medicine, Imperial College London, Flowers Building 4th Floor, Armstrong Road, London SW7 2AZ, UK
    Biochim Biophys Acta 1783:1229-36. 2008
    ..Of the Klfs which repress transcription, endothelin-1 rapidly downregulated expression of Klf3, Klf11 and Klf15...
  55. pmc The association of genetic variants in Krüppel-like factor 11 and Type 2 diabetes in the Japanese population
    T Tanahashi
    Division of Genetic Information, Institute for Genome Research, University of Tokushima, Tokushima, Japan
    Diabet Med 25:19-26. 2008
    Krüppel-like factor 11 (KLF11) is a transcriptional factor of the zinc finger domain family that regulates the expression of insulin...
  56. doi Tieg3/Klf11 induces apoptosis in OLI-neu cells and enhances the TGF-beta signaling pathway by transcriptional repression of Smad7
    Gabriele Gohla
    Department of Neuroanatomy, Center of Anatomy, Georg August University of Gottingen, Gottingen, Germany
    J Cell Biochem 104:850-61. 2008
    ..The recently identified TGF-beta-inducible zinc finger protein Tieg3/Klf11 belongs to the family of Sp1/Klf-like transcription factors and shares all structural and functional ..
  57. ncbi Minor contribution of SMAD7 and KLF10 variants to genetic susceptibility of type 2 diabetes
    R Gutierrez-Aguilar
    CNRS, UMR8090, Institute of Biologie, Institut Pasteur de Lille and Université de Lille 2, Lille, France
    Diabetes Metab 33:372-8. 2007
    ..The expression of SMAD7 is affected by KLF11, which contains gene variants that have previously been shown to be involved in genetic susceptibility to T2D, and ..
  58. ncbi Identification of minimal promoter and genetic variants of Kruppel-like factor 11 gene and association analysis with type 2 diabetes in Japanese
    Eiji Kuroda
    Department of Diabetes and Endocrinology, Division of Molecule and Structure, Gifu University School of Medicine, Gifu, Japan
    Endocr J 56:275-86. 2009
    Genetic analysis of the KLF11 gene revealed two rare variants, A347S and T220M, segregating in families with early-onset type 2 diabetes, and one frequent polymorphic Q62R variant significantly associated with type 2 diabetes in Northern ..
  59. pmc Glyceraldehyde-3-phosphate dehydrogenase-monoamine oxidase B-mediated cell death-induced by ethanol is prevented by rasagiline and 1-R-aminoindan
    Xiao Ming Ou
    Division of Neurobiology and Behavioral Research, Department of Psychiatry and Human Behavior G 109, University of Mississippi Medical Center, 2500 N State Street, Jackson, MS 39216, USA
    Neurotox Res 16:148-59. 2009
    ..In addition, GAPDH interacts with transforming growth factor-beta-inducible early gene (TIEG2), a transcriptional activator for MAO B, and this interaction is increased in the nucleus by ethanol but reduced ..
  60. doi Possible role of TIEG1 as a feedback regulator of myostatin and TGF-beta in myoblasts
    Masato Miyake
    Laboratory of Functional Morphology, Department of Animal Biology, Graduate School of Agricultural Science, Tohoku University, 1 1 Tsutsumidori Amamiyamachi, Aoba ku, Sendai 981 8555, Japan
    Biochem Biophys Res Commun 393:762-6. 2010
    ..Myostatin and TGF-beta induced the expression of TIEG1 and Smad7 mRNAs, but not TIEG2 mRNA, in proliferating C2C12 cells...
  61. ncbi {gamma}-Globin gene expression in chemical inducer of dimerization (CID)-dependent multipotential cells established from human {beta}-globin locus yeast artificial chromosome ({beta}-YAC) transgenic mice
    C Anthony Blau
    Division of Hematology, Department of Medicine, University of Washington Medical Center, Seattle, Washington 98195, USA
    J Biol Chem 280:36642-7. 2005
    ..transcription factor and the previously identified fetal globin transactivators fetal Krüppel-like factor (FKLF) and fetal globin-increasing factor (FGIF)...
  62. pmc Transcription factor KLF11 integrates progesterone receptor signaling and proliferation in uterine leiomyoma cells
    Ping Yin
    Division of Reproductive Biology Research, Department of Obstetrics and Gynecology, Feinberg School of Medicine at Northwestern University, Chicago, IL 60611, USA
    Cancer Res 70:1722-30. 2010
    ..5 kb upstream of the transcriptional start site of the Krüppel-like transcription factor 11 (KLF11) gene...
  63. doi The bile acid sensor FXR regulates insulin transcription and secretion
    Barbara Renga
    Department of Experimental and Clinical Medicine, University of Perugia, Perugia, Italy
    Biochim Biophys Acta 1802:363-72. 2010
    ..Genomic effects of FXR activation relay on the induction of the glucose regulated transcription factor KLF11. Indeed, results from silencing experiments of KLF11 demonstrate that this transcription factor is essential for ..
  64. pmc A novel role for glyceraldehyde-3-phosphate dehydrogenase and monoamine oxidase B cascade in ethanol-induced cellular damage
    Xiao Ming Ou
    Department of Psychiatry and Human Behavior, University of Mississippi Medical Center, Jackson, Mississippi 39216, USA
    Biol Psychiatry 67:855-63. 2010
    ..Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) and monoamine oxidase B (MAO B) reportedly play a role in cellular dysfunction under stressful conditions and might contribute to EtOH-induced cell damage...
  65. ncbi The transcription factor KLF11 can induce gamma-globin gene expression in the setting of in vivo adult erythropoiesis
    David W Emery
    University of Washington Department of Medicine, Division of Medical Genetics, Seattle, WA 98195 7720, USA
    J Cell Biochem 100:1045-55. 2007
    ..Previous studies in a fetal erythroid cell line demonstrated that the transcription factor, Krüppel-like factor 11 (KLF11), could specifically induce transcription from a gamma-globin gene promoter, and that this induction was mediated ..
  66. ncbi Functional domains of the TGF-beta-inducible transcription factor Tieg3 and detection of two putative nuclear localization signals within the zinc finger DNA-binding domain
    Björn Spittau
    Center of Anatomy, Department of Neuroanatomy, University of Gottingen, Kreuzbergring, Germany
    J Cell Biochem 101:712-22. 2007
    The recently identified TGF-beta-inducible early gene 3 (Tieg3) belongs to the gene family of Sp1/Klf-like transcription factors and is upregulated immediately after TGF-beta treatment...
  67. pmc Comparative analysis of gene regulation by the transcription factor PPARalpha between mouse and human
    Maryam Rakhshandehroo
    Nutrigenomics Consortium, Top Institute TI Food and Nutrition, Wageningen, The Netherlands
    PLoS ONE 4:e6796. 2009
    ..However, little information is available on the role of PPARalpha in human liver. Here we set out to compare the function of PPARalpha in mouse and human hepatocytes via analysis of target gene regulation...
  68. ncbi Role of TIEG1 in biological processes and disease states
    Malayannan Subramaniam
    Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    J Cell Biochem 102:539-48. 2007
    ..Other closely related factors [TIEG2 (KLF11) and TIEG3/TIEG2b] have been reported and are briefly compared...
  69. ncbi Gene expression profile of human bone marrow stromal cells: high-throughput expressed sequence tag sequencing analysis
    Libin Jia
    Medical Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Genomics 79:7-17. 2002
    ..It is expected that high-throughput EST sequencing and data mining analysis will greatly promote our understanding of gene expression in these cells and of growth and development of the skeleton...

Research Grants33

  1. OVERCOMING POSITION EFFECTS WITH CHROMATIN INSULATORS
    David Emery; Fiscal Year: 2007
    ..abstract_text> ..
  2. The Role of Zinc Finger Genes in Pancreatic Cell Growth
    Raul Urrutia; Fiscal Year: 2009
    ..a unifying theme by which these three areas may be linked, namely studies on novel coregulator molecules for KLF11 (the structural and functional paradigm of this subfamily of TGF-inducible KLF repressors) and their role in ..
  3. The Role of Zinc Finger Genes in Pancreatic Cell Growth
    Raul A Urrutia; Fiscal Year: 2010
    ..a unifying theme by which these three areas may be linked, namely studies on novel coregulator molecules for KLF11 (the structural and functional paradigm of this subfamily of TGF-inducible KLF repressors) and their role in ..
  4. CELLULAR MECHANISMS OF HB F REGULATION
    George Stamatoyannopoulos; Fiscal Year: 2007
    ..Our Specific Aims are: 1) Investigate the interaction of two transcriptional factors, FKLF-1 and 2 with the gamma globin gene promoter in vivo using chromatin immunoprecipitation (CHIP) assays...
  5. Transcriptional Network Controlling the Human Cell Cycle
    Heather Murray; Fiscal Year: 2005
    ..members of the E2F family, human Forkhead proteins (FKHR and FKHRL1), Serum Responsive Factor (SRF), TIEG, and TIEG2. The genomic targets of these regulators will be identified in synchronized human cells using the genome-wide ..
  6. Fine-mapping and Characterization of Metabolic Loci in the DPP Outcomes Study
    JOSE CARLOS FLOREZ; Fiscal Year: 2010
    ..In the DPP, we will test the association of select variants with baseline diabetes-related quantitative traits, incidence of metabolic outcomes, response to the lifestyle intervention, and the effects of metformin and troglitazone. ..
  7. Study to Understand the Genetics of the Acute Response to Metformin & Glipizide
    JOSE CARLOS FLOREZ; Fiscal Year: 2010
    ....
  8. Constitutive NFKB and Carcinogenesis in Barrett's Esophagus
    Navtej Buttar; Fiscal Year: 2007
    ..Moreover, the information obtained from this study may help us understand the mechanisms involved in chronic injury-related cancers elsewhere in the body. ..
  9. Pharmacogenetics of the acute response to sulfonylurea and metformin treatment in
    Jose Florez; Fiscal Year: 2007
    ..In addition, this pilot study will lay the groundwork for a long-term, outcomes-based pharmacogenetic clinical trial. ..
  10. Activation of gamma globin expression by transactivators
    Chao Zhong Song; Fiscal Year: 2004
    ..The long-term objectives of this proposal are to validate the in vivo role of the candidate globin transactivators FKLF1 and FKLF2 in globin gene expression, study the mechanisms by which they activate globin gene expression and ..
  11. Combinational Chemoprevention of Esophageal Adenocarcin*
    Navtej Buttar; Fiscal Year: 2005
    ..abstract_text> ..
  12. Genetic variation in drug targets for type 2 diabetes
    Jose Florez; Fiscal Year: 2007
    ..This proposal should serve as the foundation for a large pharmacogenomics trial designed to evaluate the feasibility of genetically-tailored therapy in T2DM. ..
  13. Growth Regulatory Mechanisms of KLF in Barrett's Epithelium
    Navtej Buttar; Fiscal Year: 2007
    ..In preliminary studies, we made the following novel observations that 1) KLF11 acts as a repressor of the cPLA2-( promoter activity and decreases PGE2 production, 2) KLF11 down-regulates the ..