KLC2

Summary

Gene Symbol: KLC2
Description: kinesin light chain 2
Alias: kinesin light chain 2, KLC 2
Species: human
Products:     KLC2

Top Publications

  1. Rahman A, Kamal A, Roberts E, Goldstein L. Defective kinesin heavy chain behavior in mouse kinesin light chain mutants. J Cell Biol. 1999;146:1277-88 pubmed
    ..Chem. 273:15395-15403). Of the two characterized gene products, KLC1 was predominant in neuronal tissues, whereas KLC2 showed a more ubiquitous pattern of expression...
  2. Rahman A, Friedman D, Goldstein L. Two kinesin light chain genes in mice. Identification and characterization of the encoded proteins. J Biol Chem. 1998;273:15395-403 pubmed
    ..These results indicate that the mammalian nervous system contains multiple kinesin light chain gene products with potentially distinct functions. ..
  3. Araki Y, Kawano T, Taru H, Saito Y, Wada S, Miyamoto K, et al. The novel cargo Alcadein induces vesicle association of kinesin-1 motor components and activates axonal transport. EMBO J. 2007;26:1475-86 pubmed
    ..Inappropriate interactions of Alc- and APP-containing vesicles with kinesin-1 may promote aberrant APP metabolism in Alzheimer's disease. ..
  4. Hu W, Tu Z. Functional analysis of the promoter of an early zygotic gene KLC2 in Aedes aegypti. Parasit Vectors. 2018;11:655 pubmed publisher
    ..In this study, we demonstrated through transgenic assays that the promoter of an endogenous early zygotic gene KLC2 could drive gene expression in the syncytial blastoderm and early cellular blastoderm, which is a stage that the ..
  5. de Farias A, Nunes K, Lemes R, Moura R, Fernandes G, Melo U, et al. Origin and age of the causative mutations in KLC2, IMPA1, MED25 and WNT7A unravelled through Brazilian admixed populations. Sci Rep. 2018;8:16552 pubmed publisher
    ..age and local ancestry to infer the origin of each chromosomal segments containing disorder-causing mutations in KLC2, IMPA1, MED25 and WNT7A...
  6. Cockburn J, Hesketh S, Mulhair P, Thomsen M, O Connell M, Way M. Insights into Kinesin-1 Activation from the Crystal Structure of KLC2 Bound to JIP3. Structure. 2018;26:1486-1498.e6 pubmed publisher
    ..the molecular basis for kinesin-1 recruitment and activation by cargoes, we solved the crystal structure of the KLC2 tetratricopeptide repeat (TPR) domain bound to the cargo JIP3...
  7. Manser C, Guillot F, Vagnoni A, Davies J, Lau K, McLoughlin D, et al. Lemur tyrosine kinase-2 signalling regulates kinesin-1 light chain-2 phosphorylation and binding of Smad2 cargo. Oncogene. 2012;31:2773-82 pubmed publisher
    ..Here, we show that LMTK2 regulates a known pathway that controls phosphorylation of kinesin-1 light chain-2 (KLC2) by glycogen synthase kinase-3β (GSK3β)...
  8. Ishida M, Ohbayashi N, Fukuda M. Rab1A regulates anterograde melanosome transport by recruiting kinesin-1 to melanosomes through interaction with SKIP. Sci Rep. 2015;5:8238 pubmed publisher
    ..on melanosomes recruits SKIP/PLEKHM2 as a Rab1A-specific effector and that Rab1A, SKIP, and a kinesin-1/(Kif5b+KLC2) motor form a transport complex that mediates anterograde melanosome transport in melanocytes...
  9. Di Gioia S, Farinelli P, Letteboer S, Arsenijevic Y, Sharon D, Roepman R, et al. Interactome analysis reveals that FAM161A, deficient in recessive retinitis pigmentosa, is a component of the Golgi-centrosomal network. Hum Mol Genet. 2015;24:3359-71 pubmed publisher
    ..Notable FAM161A interactors included AKAP9, FIP3, GOLGA3, KIFC3, KLC2, PDE4DIP, NIN and TRIP11...

More Information

Publications24

  1. Morgan G, Hollinshead M, Ferguson B, Murphy B, Carpentier D, Smith G. Vaccinia protein F12 has structural similarity to kinesin light chain and contains a motor binding motif required for virion export. PLoS Pathog. 2010;6:e1000785 pubmed publisher
    ..Moreover, molecular modeling of F12 TPRs upon the crystal structure of KLC2 TPRs showed a striking conservation of structure. We also identified multiple TPRs in VACV proteins E2 and A36...
  2. Du J, Wei Y, Liu L, Wang Y, Khairova R, Blumenthal R, et al. A kinesin signaling complex mediates the ability of GSK-3beta to affect mood-associated behaviors. Proc Natl Acad Sci U S A. 2010;107:11573-8 pubmed publisher
    ..AMPA)-induced GluR1 and GluR2 internalization via phosphorylation of kinesin light chain 2 (KLC2), the key molecule of the kinesin cargo delivery system...
  3. DuRaine G, Wisner T, Howard P, Johnson D. Kinesin-1 Proteins KIF5A, -5B, and -5C Promote Anterograde Transport of Herpes Simplex Virus Enveloped Virions in Axons. J Virol. 2018;92: pubmed publisher
    ..Silencing of kinesin-1 proteins KIF5A, -5B, and -5C or light chains KLC1 and KLC2 inhibited the majority of HSV anterograde transport, while silencing of KIF1A had little effect on HSV transport in ..
  4. Trejo H, Lecuona E, Grillo D, Szleifer I, Nekrasova O, Gelfand V, et al. Role of kinesin light chain-2 of kinesin-1 in the traffic of Na,K-ATPase-containing vesicles in alveolar epithelial cells. FASEB J. 2010;24:374-82 pubmed publisher
    ..Knockdown of kinesin-1 heavy chain (KHC) or the light chain-2 (KLC2), but not of the light chain-1 (KLC1), decreased the movement of Na,K-ATPase-containing vesicles when compared to ..
  5. Shi P, Strom A, Gal J, Zhu H. Effects of ALS-related SOD1 mutants on dynein- and KIF5-mediated retrograde and anterograde axonal transport. Biochim Biophys Acta. 2010;1802:707-16 pubmed publisher
  6. Milewska M, McRedmond J, Byrne P. Identification of novel spartin-interactors shows spartin is a multifunctional protein. J Neurochem. 2009;111:1022-30 pubmed publisher
    ..We also show for the first time interaction between spartin and a nucleolar protein, nucleolin. ..
  7. Zhu H, Lee H, Tong Y, Hong B, Kim K, Shen Y, et al. Crystal structures of the tetratricopeptide repeat domains of kinesin light chains: insight into cargo recognition mechanisms. PLoS ONE. 2012;7:e33943 pubmed publisher
    ..Despite a high sequence identity between their TPR domains (87%), KLC1 and KLC2 isoforms exhibit differential binding properties towards some cargos...
  8. Newsome T, Scaplehorn N, Way M. SRC mediates a switch from microtubule- to actin-based motility of vaccinia virus. Science. 2004;306:124-9 pubmed
    ..Thus, Src activity regulates the transition between cytoplasmic microtubule transport and actin-based motility at the plasma membrane. ..
  9. Nguyen T, Chenon M, Vilela F, Velours C, Aumont Nicaise M, Andreani J, et al. Structural plasticity of the N-terminal capping helix of the TPR domain of kinesin light chain. PLoS ONE. 2017;12:e0186354 pubmed publisher
    ..We determined crystal structures of the TPR domain of both KLC1 and KLC2 encompassing the N-terminal capping helix and show that this helix exhibits two distinct and defined orientations ..
  10. Wang M, Zhu X, Sha Z, Li N, Li D, Chen L. High expression of kinesin light chain-2, a novel target of miR-125b, is associated with poor clinical outcome of elderly non-small-cell lung cancer patients. Br J Cancer. 2015;112:874-82 pubmed publisher
    ..This study is to identify the function of KLC2 and its interaction with miR-125b in NSCLC...
  11. Yip Y, Pernigo S, Sanger A, Xu M, Parsons M, Steiner R, et al. The light chains of kinesin-1 are autoinhibited. Proc Natl Acad Sci U S A. 2016;113:2418-23 pubmed publisher
    ..biochemical, and biophysical approaches, we describe how an intramolecular interaction between the KLC2(TPR) domain and a conserved peptide motif within an unstructured region of the molecule, partly occludes the W-..
  12. Melo U, Macedo Souza L, Figueiredo T, Muotri A, Gleeson J, Coux G, et al. Overexpression of KLC2 due to a homozygous deletion in the non-coding region causes SPOAN syndrome. Hum Mol Genet. 2015;24:6877-85 pubmed publisher
    ..hg19:g.66,024,557_66,024,773del) located at the non-coding upstream region of the KLC2 gene...
  13. Raiborg C, Wenzel E, Pedersen N, Olsvik H, Schink K, Schultz S, et al. Repeated ER-endosome contacts promote endosome translocation and neurite outgrowth. Nature. 2015;520:234-8 pubmed publisher
    ..Thus, protrudin-containing ER-LE contact sites are platforms for kinesin-1 loading onto LEs, and kinesin-1-mediated translocation of LEs to the plasma membrane, fuelled by repeated ER contacts, promotes protrusion and neurite outgrowth. ..
  14. Ligon L, Tokito M, Finklestein J, Grossman F, Holzbaur E. A direct interaction between cytoplasmic dynein and kinesin I may coordinate motor activity. J Biol Chem. 2004;279:19201-8 pubmed
    ..There is also a vesicle population with both dynein and kinesin I bound that may be capable of bi-directional motility along cellular microtubules. ..
  15. Bowman A, Kamal A, Ritchings B, Philp A, McGrail M, Gindhart J, et al. Kinesin-dependent axonal transport is mediated by the sunday driver (SYD) protein. Cell. 2000;103:583-94 pubmed
    ..We propose that SYD mediates the axonal transport of at least one class of vesicles by interacting directly with KLC. ..