Gene Symbol: KLC1
Description: kinesin light chain 1
Alias: KLC, KNS2, KNS2A, kinesin light chain 1, kinesin 2 60/70kDa, medulloblastoma antigen MU-MB-2.50
Species: human
Products:     KLC1

Top Publications

  1. Verhey K, Meyer D, Deehan R, Blenis J, Schnapp B, Rapoport T, et al. Cargo of kinesin identified as JIP scaffolding proteins and associated signaling molecules. J Cell Biol. 2001;152:959-70 pubmed
  2. Nguyen Q, Lee C, Le A, Reddy E. JLP associates with kinesin light chain 1 through a novel leucine zipper-like domain. J Biol Chem. 2005;280:30185-91 pubmed
    ..We have identified kinesin light chain 1 (KLC1) as a binding partner for the second leucine zipper domain of JLP using yeast two-hybrid screening...
  3. Kamm C, Boston H, Hewett J, Wilbur J, Corey D, Hanson P, et al. The early onset dystonia protein torsinA interacts with kinesin light chain 1. J Biol Chem. 2004;279:19882-92 pubmed
    ..We identified the light chain subunit (KLC1) of kinesin-I as an interacting partner for torsinA, with binding occurring between the tetratricopeptide repeat ..
  4. Matsuda S, Matsuda Y, D ADAMIO L. Amyloid beta protein precursor (AbetaPP), but not AbetaPP-like protein 2, is bridged to the kinesin light chain by the scaffold protein JNK-interacting protein 1. J Biol Chem. 2003;278:38601-6 pubmed
    ..AbetaPP transport is supposedly mediated by the direct AbetaPP-Klc1 interaction...
  5. Araki Y, Kawano T, Taru H, Saito Y, Wada S, Miyamoto K, et al. The novel cargo Alcadein induces vesicle association of kinesin-1 motor components and activates axonal transport. EMBO J. 2007;26:1475-86 pubmed
    ..Inappropriate interactions of Alc- and APP-containing vesicles with kinesin-1 may promote aberrant APP metabolism in Alzheimer's disease. ..
  6. Andersson M, Sjölander A, Andreasen N, Minthon L, Hansson O, Bogdanovic N, et al. Kinesin gene variability may affect tau phosphorylation in early Alzheimer's disease. Int J Mol Med. 2007;20:233-9 pubmed
    ..In man, one study suggests that a polymorphism (rs8702, 56,836G>C) in the kinesin light chain 1 gene (KNS2) may affect the risk of Alzheimer's disease (AD)...
  7. Andersson M, Zetterberg M, Tasa G, Seibt Palmér M, Juronen E, Teesalu P, et al. Variability in the kinesin light chain 1 gene may influence risk of age-related cataract. Mol Vis. 2007;13:993-6 pubmed
    ..Here, we test the hypothesis that the rs8702 polymorphism in the kinesin light chain 1 gene (KLC1), previously linked to Alzheimer disease (AD), may play a role in cataractogenesis...
  8. von Otter M, Landgren S, Nilsson S, Lundvall C, Minthon L, Bogdanovic N, et al. Kinesin light chain 1 gene haplotypes in three conformational diseases. Neuromolecular Med. 2010;12:229-36 pubmed publisher
    ..Genetic variation in the kinesin light chain 1-encoding gene (KLC1) was tagged by six tag single nucleotide polymorphisms (SNPs)...
  9. Kamal A, Stokin G, Yang Z, Xia C, Goldstein L. Axonal transport of amyloid precursor protein is mediated by direct binding to the kinesin light chain subunit of kinesin-I. Neuron. 2000;28:449-59 pubmed
    ..and axonal transport of APP is greatly decreased in a gene-targeted mouse mutant of the neuronally enriched KLC1 gene...

More Information


  1. Bowman A, Kamal A, Ritchings B, Philp A, McGrail M, Gindhart J, et al. Kinesin-dependent axonal transport is mediated by the sunday driver (SYD) protein. Cell. 2000;103:583-94 pubmed
    ..reveal that SYD directly binds kinesin-I via the tetratricopeptide repeat (TPR) domain of kinesin light chain (KLC) with K(d) congruent with 200 nM...
  2. Khodjakov A, Lizunova E, Minin A, Koonce M, Gyoeva F. A specific light chain of kinesin associates with mitochondria in cultured cells. Mol Biol Cell. 1998;9:333-43 pubmed
    ..To test this hypothesis, we isolated KLC cDNA clones from a CHO-K1 expression library...
  3. Vagnoni A, Rodriguez L, Manser C, De Vos K, Miller C. Phosphorylation of kinesin light chain 1 at serine 460 modulates binding and trafficking of calsyntenin-1. J Cell Sci. 2011;124:1032-42 pubmed publisher
    b>Kinesin light chain 1 (KLC1) binds to the intracellular cytoplasmic domain of the type-1 membrane-spanning protein calsyntenin-1 (also known as alcadein-?) to mediate transport of a subset of vesicles...
  4. Cabeza Arvelaiz Y, Shih L, Hardman N, Asselbergs F, Bilbe G, Schmitz A, et al. Cloning and genetic characterization of the human kinesin light-chain (KLC) gene. DNA Cell Biol. 1993;12:881-92 pubmed
    We report the isolation, sequence, and identification of a cDNA encoding the human kinesin light-chain (KLC) protein...
  5. Gyoeva F, Bybikova E, Minin A. An isoform of kinesin light chain specific for the Golgi complex. J Cell Sci. 2000;113 ( Pt 11):2047-54 pubmed
    ..Thus, the results of this and previous studies demonstrate that different kinesin light chains are associated with different organelles in cells. ..
  6. Rahman A, Kamal A, Roberts E, Goldstein L. Defective kinesin heavy chain behavior in mouse kinesin light chain mutants. J Cell Biol. 1999;146:1277-88 pubmed
    ..D.S. Friedman, and L.S. Goldstein. 1998. J. Biol. Chem. 273:15395-15403). Of the two characterized gene products, KLC1 was predominant in neuronal tissues, whereas KLC2 showed a more ubiquitous pattern of expression...
  7. Rahman A, Friedman D, Goldstein L. Two kinesin light chain genes in mice. Identification and characterization of the encoded proteins. J Biol Chem. 1998;273:15395-403 pubmed
    ..These results indicate that the mammalian nervous system contains multiple kinesin light chain gene products with potentially distinct functions. ..
  8. McCart A, Mahony D, Rothnagel J. Alternatively spliced products of the human kinesin light chain 1 (KNS2) gene. Traffic. 2003;4:576-80 pubmed
    ..We have identified 19 variants of the human KNS2 gene (KLC1) that are generated by alternative splicing of downstream exons, but calculate that KNS2 has the ..
  9. Dhaenens C, Van Brussel E, Schraen Maschke S, Pasquier F, Delacourte A, Sablonniere B. Association study of three polymorphisms of kinesin light-chain 1 gene with Alzheimer's disease. Neurosci Lett. 2004;368:290-2 pubmed
    The transport of amyloid precursor protein is mediated through its interaction with kinesin light-chain 1 (KNS2). We hypothesized that kinesin light-chain dysfunction might be involved in the pathogenesis of Alzheimer's disease (AD)...
  10. Prots I, Grosch J, Brazdis R, Simmnacher K, Veber V, Havlicek S, et al. ?-Synuclein oligomers induce early axonal dysfunction in human iPSC-based models of synucleinopathies. Proc Natl Acad Sci U S A. 2018;115:7813-7818 pubmed publisher
    ..Furthermore, ?-Syn oligomers were associated with a subcellular relocation of transport-regulating proteins Miro1, KLC1, and Tau as well as reduced ATP levels, underlying axonal transport deficits...
  11. Liang Y, Yang W. Kinesins in MAPK cascade: How kinesin motors are involved in the MAPK pathway?. Gene. 2019;684:1-9 pubmed publisher
    ..Studies have indicated that Kinesin-1 light chain KLC1, Kinesin-1 heavy chain KIF5B and Kinesin-11 family motor KIF26B interact with extracellular signal-regulated kinase ..
  12. Nakano Y, Tomiyama A, Kohno T, Yoshida A, Yamasaki K, Ozawa T, et al. Identification of a novel KLC1-ROS1 fusion in a case of pediatric low-grade localized glioma. Brain Tumor Pathol. 2019;36:14-19 pubmed publisher
    ..We describe a novel KLC1-ROS1 fusion identified in a case of pediatric low-grade glioma...
  13. DuRaine G, Wisner T, Howard P, Johnson D. Kinesin-1 Proteins KIF5A, -5B, and -5C Promote Anterograde Transport of Herpes Simplex Virus Enveloped Virions in Axons. J Virol. 2018;92: pubmed publisher
    ..Silencing of kinesin-1 proteins KIF5A, -5B, and -5C or light chains KLC1 and KLC2 inhibited the majority of HSV anterograde transport, while silencing of KIF1A had little effect on HSV ..
  14. Chiba K, Araseki M, Nozawa K, Furukori K, Araki Y, Matsushima T, et al. Quantitative analysis of APP axonal transport in neurons: role of JIP1 in enhanced APP anterograde transport. Mol Biol Cell. 2014;25:3569-80 pubmed publisher
    ..to JIP1 function, located in the central region of JIP1b, that interact with the coiled-coil domain of kinesin light chain 1 (KLC1), in addition to the conventional interaction of the JIP1b 11-amino acid C-terminal (C11) region ..
  15. Yip Y, Pernigo S, Sanger A, Xu M, Parsons M, Steiner R, et al. The light chains of kinesin-1 are autoinhibited. Proc Natl Acad Sci U S A. 2016;113:2418-23 pubmed publisher
    ..Through their tetratricopeptide repeat domain (KLC(TPR)), they can recognize short linear peptide motifs found in many cargo proteins characterized by a central ..
  16. Konecna A, Frischknecht R, Kinter J, Ludwig A, Steuble M, Meskenaite V, et al. Calsyntenin-1 docks vesicular cargo to kinesin-1. Mol Biol Cell. 2006;17:3651-63 pubmed
    ..a direct interaction between the neuronal transmembrane protein calsyntenin-1 and the light chain of Kinesin-1 (KLC1)...
  17. Yu L, Wang J, Guo D, You W, Liu M, Zhang L, et al. The kinetics and mechanism of photo-assisted Ag(I)-catalysed water oxidation with S2O8(2-). Dalton Trans. 2015;44:710-7 pubmed publisher
    ..The rate law is expressed as -dc(S2O8(2-))/dt = 2dc(O2)/dt = kLc(S2O8(2-))c(Ag(+)), where kL is 12.4 ± 1 mol(-1) L h(-1) at 24.5 °C and the activation energy is 3...
  18. Zheng Q, Zheng M, Jin Y, Shen X, Shan L, Shen L, et al. ALK-rearrangement neuroendocrine carcinoma of the lung: a comprehensive study of a rare case series and review of literature. Onco Targets Ther. 2018;11:4991-4998 pubmed publisher
    ..One case of combined LCNEC with adenocarcinoma harboring KLC1-ALK (K9:A20) fusion genes was confirmed by NGS of both components, while only the LCNEC component presented ..
  19. Jiang M, Esteve Rudd J, Lopes V, Diemer T, Lillo C, Rump A, et al. Microtubule motors transport phagosomes in the RPE, and lack of KLC1 leads to AMD-like pathogenesis. J Cell Biol. 2015;210:595-611 pubmed publisher
    ..showed that the phagosomes moved bidirectionally along microtubules in RPE cells, with kinesin-1 light chain 1 (KLC1) remaining associated in both directions and during pauses...
  20. Cockburn J, Hesketh S, Mulhair P, Thomsen M, O Connell M, Way M. Insights into Kinesin-1 Activation from the Crystal Structure of KLC2 Bound to JIP3. Structure. 2018;26:1486-1498.e6 pubmed publisher
    Kinesin-1 transports numerous cellular cargoes along microtubules. The kinesin-1 light chain (KLC) mediates cargo binding and regulates kinesin-1 motility...
  21. Morgan G, Hollinshead M, Ferguson B, Murphy B, Carpentier D, Smith G. Vaccinia protein F12 has structural similarity to kinesin light chain and contains a motor binding motif required for virion export. PLoS Pathog. 2010;6:e1000785 pubmed publisher
    ..Here we show that F12 has structural similarity to kinesin light chain (KLC), a subunit of the kinesin-1 motor that binds cargo...
  22. Wang M, Zhu X, Sha Z, Li N, Li D, Chen L. High expression of kinesin light chain-2, a novel target of miR-125b, is associated with poor clinical outcome of elderly non-small-cell lung cancer patients. Br J Cancer. 2015;112:874-82 pubmed publisher
    ..Kinesin-1 light chain (KLC)-2 was predicted as one of miR-125b's targets by bioinformatics analysis...
  23. Wilson M, Holzbaur E. Nesprins anchor kinesin-1 motors to the nucleus to drive nuclear distribution in muscle cells. Development. 2015;142:218-28 pubmed publisher
    ..Second, we identify a conserved kinesin light chain (KLC)-binding motif in the nuclear envelope proteins nesprin-1 and nesprin-2, and show that recruitment of the motor ..
  24. Nguyen T, Aumont Nicaise M, Andreani J, Velours C, Chenon M, Vilela F, et al. Characterization of the binding mode of JNK-interacting protein 1 (JIP1) to kinesin-light chain 1 (KLC1). J Biol Chem. 2018;293:13946-13960 pubmed publisher
    ..JIP1 is specifically recruited by the kinesin-light chain 1 (KLC1) of kinesin1, but the details of this interaction are not yet fully elucidated...
  25. Carpentier D, Gao W, Ewles H, Morgan G, Smith G. Vaccinia virus protein complex F12/E2 interacts with kinesin light chain isoform 2 to engage the kinesin-1 motor complex. PLoS Pathog. 2015;11:e1004723 pubmed publisher
    ..in the outer membrane of IEVs, and over-expressed fragments of this protein interact with kinesin light chain (KLC). However, no interaction of F12 or E2 with the kinesin complex has been reported hitherto...
  26. Wen Z, Zhang M. Salsola laricifolia, another C3-C 4 intermediate species in tribe Salsoleae s.l. (Chenopodiaceae). Photosynth Res. 2015;123:33-43 pubmed publisher
    ..arbusculiformis, a relatively low CO2 compensation point (30.4 μmol mol(-1)) and mesophyll (M)-to KLC tissue ratio, mitochondria in KLCs primarily occurring along the centripetal wall, and specific localization of P-..
  27. Bayés García L, Calvet T, Cuevas Diarte M, Ueno S. In situ crystallization and transformation kinetics of polymorphic forms of saturated-unsaturated-unsaturated triacylglycerols: 1-palmitoyl-2,3-dioleoyl glycerol, 1-stearoyl-2,3-dioleoyl glycerol, and 1-palmitoyl-2-oleoyl-3-linoleoyl glycerol. Food Res Int. 2016;85:244-258 pubmed publisher
    ..Transient disordered phases, defined as kinetic liquid crystal (KLC) phases, were determined in POO and SOO for the first time...
  28. Watt D, Dixit R, Cavalli V. JIP3 Activates Kinesin-1 Motility to Promote Axon Elongation. J Biol Chem. 2015;290:15512-25 pubmed publisher
    ..heavy chains (KHC), which harbor the motor domain, or as a tetramer in combination with two accessory light chains (KLC). To ensure proper cargo distribution, kinesin-1 activity is precisely regulated...
  29. Zheng Y, Tian S, Peng X, Yang J, Fu Y, Jiao Y, et al. Kinesin-1 inhibits the aggregation of amyloid-? peptide as detected by fluorescence cross-correlation spectroscopy. FEBS Lett. 2016;590:1028-37 pubmed publisher
    ..that two kinds of enhanced green fluorescent protein (EGFP)-tagged kinesin light-chain subunits of kinesin-1(KLCs), KLC-E and E-KLC inhibited the aggregation of A? over a period of time, providing additional insight into the mechanism ..
  30. Novas R, Cardenas Rodriguez M, Lepanto P, Fabregat M, Rodao M, Fariello M, et al. Kinesin 1 regulates cilia length through an interaction with the Bardet-Biedl syndrome related protein CCDC28B. Sci Rep. 2018;8:3019 pubmed publisher
    ..CCDC28B interacts with kinesin light chain 1 (KLC1) and the heavy chain KIF5B...
  31. Medina C, Biris O, Falzone T, Zhang X, Zimmerman A, Bearer E. Hippocampal to basal forebrain transport of Mn2+ is impaired by deletion of KLC1, a subunit of the conventional kinesin microtubule-based motor. Neuroimage. 2017;145:44-57 pubmed publisher
    ..nervous system, focusing on the hippocampal-forebrain circuit, and comparing kinesin-1 light chain 1 knock-out (KLC-KO) mice with age-matched wild-type littermates...
  32. Okuda H, Deboer K, O Connor A, Merriner D, Jamsai D, O Bryan M. LRGUK1 is part of a multiprotein complex required for manchette function and male fertility. FASEB J. 2017;31:1141-1152 pubmed publisher
    ..HOOK family of proteins (HOOK-1-3), Rab3-interacting molecule binding protein (RIMBP)-3 and kinesin light chain (KLC)-3, all of which are associated with intracellular protein transport as cargo adaptor proteins and are localized to ..
  33. Akiyama M, Takeichi T, McGrath J, Sugiura K. Autoinflammatory keratinization diseases: An emerging concept encompassing various inflammatory keratinization disorders of the skin. J Dermatol Sci. 2018;90:105-111 pubmed publisher
    ..pustular psoriasis, pityriasis rubra pilaris (PRP) type V, and familial keratosis lichenoides chronica (KLC)...
  34. Sanger A, Yip Y, Randall T, Pernigo S, Steiner R, Dodding M. SKIP controls lysosome positioning using a composite kinesin-1 heavy and light chain-binding domain. J Cell Sci. 2017;130:1637-1651 pubmed publisher
    ..Mutational separation of KHC and KLC binding shows that both interactions are important for SKIP-kinesin-1 interaction in vitro and that KHC ..
  35. Sherman M, LaCroix M, Amar F, Larson M, Forster C, Aguzzi A, et al. Soluble Conformers of Aβ and Tau Alter Selective Proteins Governing Axonal Transport. J Neurosci. 2016;36:9647-58 pubmed publisher
    ..with the intracellular accumulation of the precursor protein of Aβ, APP, as a result of the selective decrease in kinesin light chain 1 expression. Our findings suggest that Aβ trimers might cause axonal transport deficits in AD.
  36. Melkov A, Simchoni Y, Alcalay Y, Abdu U. Dynamic microtubule organization and mitochondrial transport are regulated by distinct Kinesin-1 pathways. Biol Open. 2015;4:1696-706 pubmed publisher
    ..We found that mutations in Khc and the gene of its adaptor protein, kinesin light chain (Klc) resulted in identical bristle morphology defects, with the upper part of the bristle being thinner and flatter ..
  37. Dogan S, Kılınç E, Özaygen G, Atakan N, Gokoz O, Evans S. Childhood-Onset Keratosis Lichenoides Chronica Accompanied by Severe Hair Loss. Skinmed. 2017;15:211-213 pubmed
    ..Hyalinization and abundant melanin in the papillary dermis and marked congestion of blood vessels were noted (Figure 2). Clinicopathologic correlation of the case was consistent with keratosis lichenoides chronica (KLC).
  38. CYRUS B, Muller W. A Unique Role for Endothelial Cell Kinesin Light Chain 1, Variant 1 in Leukocyte Transendothelial Migration. Am J Pathol. 2016;186:1375-86 pubmed publisher
    ..variant 1 (KLC1C) significantly decreased LBRC-targeted recycling and TEM, whereas knocking down other isoforms of KLC1 had no effect. Re-expression of KLC1C resistant to the knockdown shRNA restored targeted recycling and TEM...
  39. Sun J, Pan C, Chew T, Liang F, Burmeister M, Low B. BNIP-H Recruits the Cholinergic Machinery to Neurite Terminals to Promote Acetylcholine Signaling and Neuritogenesis. Dev Cell. 2015;34:555-68 pubmed publisher
    ..Here, we demonstrate that ataxia-related protein BNIP-H/Caytaxin links kinesin-1 (KLC1) to ATP citrate lyase (ACL), a key enzyme for ACh synthesis, and transports it toward neurite terminals...
  40. Biswas S, Blissard G, Theilmann D. Trichoplusia ni Kinesin-1 Associates with Autographa californica Multiple Nucleopolyhedrovirus Nucleocapsid Proteins and Is Required for Production of Budded Virus. J Virol. 2016;90:3480-95 pubmed publisher
    ..by fluorescence lifetime imaging to interact directly with the Drosophila melanogaster kinesin-1 light chain (KLC) tetratricopeptide repeat (TPR) domain...
  41. McCoach C, Blakely C, Banks K, Levy B, Chue B, Raymond V, et al. Clinical Utility of Cell-Free DNA for the Detection of ALK Fusions and Genomic Mechanisms of ALK Inhibitor Resistance in Non-Small Cell Lung Cancer. Clin Cancer Res. 2018;24:2758-2770 pubmed publisher
    ..b>Results: Identified fusion partners included EML4 (85.4%), STRN (6%), and KCNQ, KLC1, KIF5B, PPM1B, and TGF (totaling 8.3%)...
  42. Wobst H, Schmitz B, Schachner M, Diestel S, Leshchyns ka I, Sytnyk V. Kinesin-1 promotes post-Golgi trafficking of NCAM140 and NCAM180 to the cell surface. J Cell Sci. 2015;128:2816-29 pubmed publisher
    ..We used a protein macroarray and identified the kinesin light chain 1 (KLC1), a component of the kinesin-1 motor protein, as a binding partner of the intracellular domains of ..
  43. Alborghetti M, Furlan A, da Silva J, Sforça M, Honorato R, Granato D, et al. Structural analysis of intermolecular interactions in the kinesin adaptor complex fasciculation and elongation protein zeta 1/ short coiled-coil protein (FEZ1/SCOCO). PLoS ONE. 2013;8:e76602 pubmed publisher
  44. Diefenbach R, Diefenbach E, Douglas M, Cunningham A. The heavy chain of conventional kinesin interacts with the SNARE proteins SNAP25 and SNAP23. Biochemistry. 2002;41:14906-15 pubmed
    ..In support of separate binding sites on heavy chain for light chain and SNAPs, a complex of heavy and light chains was observed to interact with SNAP25 and SNAP23. ..
  45. Pu J, Schindler C, Jia R, Jarnik M, Backlund P, Bonifacino J. BORC, a multisubunit complex that regulates lysosome positioning. Dev Cell. 2015;33:176-88 pubmed publisher
    ..In turn, this causes reduced cell spreading and migration, highlighting the importance of BORC-dependent centrifugal transport for non-degradative functions of lysosomes. ..
  46. Szolnoki Z, Kondacs A, Mandi Y, Somogyvari F. A genetic variant in cytoskeleton motors amplifies susceptibility to leukoaraiosis in hypertensive smokers: gene-environmental interactions behind vascular white matter demyelinization. J Mol Neurosci. 2007;33:173-9 pubmed
    ..Setting out from this assumption, we examined how the kinesin light-chain 1 (KNS2) G56836C single nucleotide polymorphism in intron 13 affects the susceptibility to LA...
  47. Szolnoki Z, Kondacs A, Mandi Y, Somogyvari F. Evaluation of the roles of the A185C and C406T kinesin light-chain 1 variants in the development of leukoaraiosis. Neurosci Lett. 2007;429:101-4 pubmed
    ..Setting out from this assumption, we earlier found that the kinesin light-chain 1 (KNS2) cytoskeleton motor protein 56836CC single nucleotide polymorphism conferred a risk of LA in hypertensive smokers...
  48. Szolnoki Z, Kondacs A, Mandi Y, Somogyvari F. Gene-environmental effects behind leukoaraiosis: a silent genetic variant of the kinesin protein can be activated in a subject with poorly controlled long-lasting hypertension. Clin Biochem. 2009;42:630-3 pubmed publisher
    The rs8702 variant of the kinesin light chain 1 was earlier found to be a risk factor for vascular white matter demyelinization, referred to as leukoaraiosis (LA), in hypertensive smokers...
  49. Killian R, Flippin J, Herrera C, Almenar Queralt A, Goldstein L. Kinesin light chain 1 suppression impairs human embryonic stem cell neural differentiation and amyloid precursor protein metabolism. PLoS ONE. 2012;7:e29755 pubmed publisher
    ..to address this issue, we generated human embryonic stem cells (hESC) expressing reduced levels of the kinesin light chain 1 (KLC1) Kinesin-1 subunit to use as a source of human neural cultures...
  50. Goedert M, Marsh S, Carter N. Localization of the human kinesin light chain gene (KNS2) to chromosome 14q32.3 by fluorescence in situ hybridization. Genomics. 1996;32:173-5 pubmed
  51. Chiba K, Chien K, Sobu Y, Hata S, Kato S, Nakaya T, et al. Phosphorylation of KLC1 modifies interaction with JIP1 and abolishes the enhanced fast velocity of APP transport by kinesin-1. Mol Biol Cell. 2017;28:3857-3869 pubmed publisher
    ..we showed that EFV requires conventional interaction between the JIP1b C-terminal region and the kinesin light chain 1 (KLC1) tetratricopeptide repeat, whereas EHF requires a novel interaction between the central region of ..
  52. Sobu Y, Furukori K, Chiba K, Nairn A, Kinjo M, Hata S, et al. Phosphorylation of multiple sites within an acidic region of Alcadein α is required for kinesin-1 association and Golgi exit of Alcadein α cargo. Mol Biol Cell. 2017;28:3844-3856 pubmed publisher
    ..in its cytoplasmic domain directly bind the tetratricopeptide repeat (TPR) motifs of the kinesin light chain (KLC), which activate kinesin-1 and recruit kinesin-1 to Alcα cargo...
  53. Chen L, Wang Y, Tseng G. Cortical compression rapidly trimmed transcallosal projections and altered axonal anterograde transport machinery. Neuroscience. 2017;362:79-94 pubmed publisher
    ..III-tubulin and kinesin light chain (KLC) expressions in the corpus callosum (CC) where transcallosal axons traveled were also decreased...
  54. Miki H, Okada Y, Hirokawa N. Analysis of the kinesin superfamily: insights into structure and function. Trends Cell Biol. 2005;15:467-76 pubmed
    ..This comprehensive classification builds on the recently proposed standardized nomenclature for kinesins and allows systematic analysis of the structural and functional relationships within the kinesin superfamily. ..
  55. Woods W, Boettcher J, Zhou D, Kloepper K, Hartman K, Ladror D, et al. Conformation-specific binding of alpha-synuclein to novel protein partners detected by phage display and NMR spectroscopy. J Biol Chem. 2007;282:34555-67 pubmed
    ..These results confirm that the helical N terminus of AS can mediate specific interactions with other proteins and suggest that membrane binding may regulate the physiological activity of AS in vivo. ..
  56. Szolnoki Z, Serly J, Kondacs A, Mandi Y, Somogyvari F. Evaluation of the genetic variants of kinesin motor protein in ischemic stroke. J Stroke Cerebrovasc Dis. 2009;18:360-2 pubmed publisher
    ..The examined 3 genetic variants seem to influence the responses of the glial cells to a slight chronic hypoxia state, rather than the mechanisms resulting in cerebral infarcts themselves. ..
  57. Behrends U, Schneider I, Rössler S, Frauenknecht H, Golbeck A, Lechner B, et al. Novel tumor antigens identified by autologous antibody screening of childhood medulloblastoma cDNA libraries. Int J Cancer. 2003;106:244-51 pubmed
    ..These findings indicate that the humoral immune response against medulloblastoma is directed against diverse antigens that may be useful as diagnostic markers or targets for immunotherapy. ..
  58. Bhullar B, Zhang Y, Junco A, Oko R, van der Hoorn F. Association of kinesin light chain with outer dense fibers in a microtubule-independent fashion. J Biol Chem. 2003;278:16159-68 pubmed
    ..The interaction between the heavy and light chains is mediated by the KLC heptad repeat (HR), a leucine zipper-like motif...
  59. Atherton J, Farabella I, Yu I, Rosenfeld S, Houdusse A, Topf M, et al. Conserved mechanisms of microtubule-stimulated ADP release, ATP binding, and force generation in transport kinesins. elife. 2014;3:e03680 pubmed publisher
    ..Our data thus provide evidence for a conserved ATP-driven mechanism for kinesins and reveal the critical mechanistic contribution of the microtubule interface. ..
  60. Bernat A, Massimi P, Banks L. Complementation of a p300/CBP defective-binding mutant of adenovirus E1a by human papillomavirus E6 proteins. J Gen Virol. 2002;83:829-33 pubmed
    ..In contrast, a mutant of HPV-16 E6 which does not bind p300 failed to rescue the E1a mutant. These results suggest that the E6-p300 interaction may be important for the ability of HPV E6 to contribute towards cell transformation. ..
  61. Taylor C, Miller B, Shah S, Parish C. A molecular dynamics study of the binary complexes of APP, JIP1, and the cargo binding domain of KLC. Proteins. 2017;85:221-234 pubmed publisher
    ..The cargo binding domain of the kinesin-1 light chain motor protein (KLC1) may be responsible for transporting APP either directly or via interaction with C-jun N-terminal kinase-..
  62. Sun T, Li Y, Li T, Ma H, Guo Y, Jiang X, et al. JIP1 and JIP3 cooperate to mediate TrkB anterograde axonal transport by activating kinesin-1. Cell Mol Life Sci. 2017;74:4027-4044 pubmed publisher
    ..kinesin-1 autoinhibition, which depends on the binding of JIP1 to kinesin-1 heavy chain (KHC) and light chain (KLC) and the binding of JIP3 to KLC and is essential for TrkB anterograde axonal transport and BDNF-induced TrkB ..
  63. Muresan Z, Muresan V. Coordinated transport of phosphorylated amyloid-beta precursor protein and c-Jun NH2-terminal kinase-interacting protein-1. J Cell Biol. 2005;171:615-25 pubmed
    ..These results indicate that the phosphorylation of APP regulates the formation of a pAPP-JIP-1 complex that accumulates in neurites independent of nonphosphorylated APP. ..
  64. Figl A, Scherer D, Nagore E, Bermejo J, Botella Estrada R, Gast A, et al. Single-nucleotide polymorphisms in DNA-repair genes and cutaneous melanoma. Mutat Res. 2010;702:8-16 pubmed publisher
    ..additional polymorphisms together with T241M XRCC3 that tagged the entire gene region and the neighbouring genes KLC1, ZFYVE21 and PPP1R13B were not associated with the disease risk; neither were the inferred haplotypes...
  65. Henry T, Couillault C, Rockenfeller P, Boucrot E, Dumont A, Schroeder N, et al. The Salmonella effector protein PipB2 is a linker for kinesin-1. Proc Natl Acad Sci U S A. 2006;103:13497-502 pubmed
    ..Taken together, our data indicate that the TTSS-2-mediated fine-tuning of kinesin-1 activity associated with the bacterial vacuole is crucial for the virulence of Salmonella. ..
  66. Szolnoki Z, Kondacs A, Mandi Y, Somogyvari F. A cytoskeleton motor protein genetic variant may exert a protective effect on the occurrence of multiple sclerosis: the janus face of the kinesin light-chain 1 56836CC genetic variant. Neuromolecular Med. 2007;9:335-9 pubmed
    ..In this study, we examined how the kinesin light-chain 1 (KLC1) G56836C (rs8702) single nucleotide polymorphism (SNP) in intron 13 affects the occurrence of MS...
  67. Akamatsu R, Ishida Kitagawa N, Aoyama T, Oka C, Kawaichi M. BNIP-2 binds phosphatidylserine, localizes to vesicles, and is transported by kinesin-1. Genes Cells. 2015;20:135-52 pubmed publisher
    ..BNIP-2 interacts with KLC through the conserved WED motif in the N-terminal region of BNIP-2...
  68. Wu M, Zheng C, Yuan R, Sun M, Xu Y, Ye J. The link between apolipoprotein E, presenilin 1, and kinesin light chain 1 gene polymorphisms and age-related cortical cataracts in the Chinese population. Mol Vis. 2015;21:412-6 pubmed
    To study whether presenilin 1 (PSEN1), apolipoprotein E (APOE), and kinesin light chain 1 (KLC1) genotypes are associated with the risk of developing age-related cortical cataracts in the Han Chinese population...
  69. Boucrot E, Henry T, Borg J, Gorvel J, Méresse S. The intracellular fate of Salmonella depends on the recruitment of kinesin. Science. 2005;308:1174-8 pubmed
    ..Among these effectors, SifA targeted SKIP, a host protein that down-regulated the recruitment of kinesin on the bacterial vacuole and, in turn, controlled vacuolar membrane dynamics. ..
  70. Chernajovsky Y, Brown A, Clark J. Human kinesin light (beta) chain gene: DNA sequence and functional characterization of its promoter and first exon. DNA Cell Biol. 1996;15:965-74 pubmed
    ..Its deletion decreases the efficiency of in vitro translation of beta kinesin mRNA and confers increased translation to a CAT reporter gene. ..
  71. Lolkema M, Mans D, Snijckers C, van Noort M, van Beest M, Voest E, et al. The von Hippel-Lindau tumour suppressor interacts with microtubules through kinesin-2. FEBS Lett. 2007;581:4571-6 pubmed
    ..The interaction with kinesin-2 facilitates pVHL binding to microtubules. These data suggest that microtubule-dependent functions of pVHL are influenced by kinesin-2. ..
  72. Aoyama T, Hata S, Nakao T, Tanigawa Y, Oka C, Kawaichi M. Cayman ataxia protein caytaxin is transported by kinesin along neurites through binding to kinesin light chains. J Cell Sci. 2009;122:4177-85 pubmed publisher
    ..The tetratricopeptide-repeat region of KLC1 recognizes the ELEWED sequence (amino acids 115-120) of caytaxin...
  73. Nguyen T, Chenon M, Vilela F, Velours C, Aumont Nicaise M, Andreani J, et al. Structural plasticity of the N-terminal capping helix of the TPR domain of kinesin light chain. PLoS ONE. 2017;12:e0186354 pubmed publisher
    ..We determined crystal structures of the TPR domain of both KLC1 and KLC2 encompassing the N-terminal capping helix and show that this helix exhibits two distinct and defined ..
  74. Dodding M, Mitter R, Humphries A, Way M. A kinesin-1 binding motif in vaccinia virus that is widespread throughout the human genome. EMBO J. 2011;30:4523-38 pubmed publisher
    ..proteins interact with the kinesin light chain outside the context of infection and have distinct preferences for KLC1 and KLC2...
  75. Zhou C, Li C, Zhou B, Sun H, Koullourou V, Holt I, et al. Novel nesprin-1 mutations associated with dilated cardiomyopathy cause nuclear envelope disruption and defects in myogenesis. Hum Mol Genet. 2017;26:2258-2276 pubmed publisher
    ..During C2C12 muscle cell differentiation, nesprin-1 levels are increased concomitantly with kinesin light chain (KLC-1/2) and immunoprecipitation and GST pull-down showed that these proteins interacted via a recently identified LEWD ..
  76. Zhu H, Lee H, Tong Y, Hong B, Kim K, Shen Y, et al. Crystal structures of the tetratricopeptide repeat domains of kinesin light chains: insight into cargo recognition mechanisms. PLoS ONE. 2012;7:e33943 pubmed publisher
    ..Despite a high sequence identity between their TPR domains (87%), KLC1 and KLC2 isoforms exhibit differential binding properties towards some cargos...
  77. Veeranan Karmegam R, Boggupalli D, Liu G, Gonsalvez G. A new isoform of Drosophila non-muscle Tropomyosin 1 interacts with Kinesin-1 and functions in oskar mRNA localization. J Cell Sci. 2016;129:4252-4264 pubmed
    ..localization of osk mRNA requires the Kinesin heavy chain (Khc) motor subunit, but not the Kinesin light chain (Klc) adaptor...
  78. Morihara T, Hayashi N, Yokokoji M, Akatsu H, Silverman M, Kimura N, et al. Transcriptome analysis of distinct mouse strains reveals kinesin light chain-1 splicing as an amyloid-? accumulation modifier. Proc Natl Acad Sci U S A. 2014;111:2638-43 pubmed publisher
    ..Additional transcriptome analysis of APP-Tg mice with mixed genetic backgrounds revealed kinesin light chain-1 (Klc1) as an A? modifier, indicating a role for intracellular trafficking in A? accumulation...
  79. Jang W, Jeong Y, Choi S, Kim S, Urm S, Seog D. Dynamin-1-like protein (Dnm1L) interaction with kinesin light chain 1 (KLC1) through the tetratricopeptide repeat (TPR) domains. Biosci Biotechnol Biochem. 2014;78:2069-72 pubmed publisher
    b>Kinesin light chain 1 (KLC1) mediates binding of KIF5 motor to specific cargo. Using the yeast two-hybrid screening, we found that mitochondrial fission protein dynamin-1-like protein (Dnm1L) interacted with KLC1, but not KIF5...
  80. Zhang L, Xu J, Qu X, Liu D, Liu P, Zhao X. Association of a rare haplotype in Kinesin light chain 1 gene with age-related cataract in a han chinese population. PLoS ONE. 2013;8:e64052 pubmed publisher
    ..In the haplotypic analysis, the haplotypes consisting of rs7154572, rs7150141 and rs12432994 in Kinesin Light Chain 1 Gene (KLC1) showed significant association with ARC (p?=?0.000878)...