KITLG

Summary

Gene Symbol: KITLG
Description: KIT ligand
Alias: DCUA, DFNA69, FPH2, FPHH, KL-1, Kitl, MGF, SCF, SHEP7, SLF, kit ligand, c-Kit ligand, familial progressive hyperpigmentation 2, mast cell growth factor, steel factor, stem cell factor
Species: human
Products:     KITLG

Top Publications

  1. Yasuda A, Sawai H, Takahashi H, Ochi N, Matsuo Y, Funahashi H, et al. Stem cell factor/c-kit receptor signaling enhances the proliferation and invasion of colorectal cancer cells through the PI3K/Akt pathway. Dig Dis Sci. 2007;52:2292-300 pubmed
    ..In KIT-positive lines, KIT was activated by stem cell factor (SCF). SCF enhanced cellular proliferation of positive lines as demonstrated by the WST-1 proliferation assay...
  2. Huang E, Nocka K, Buck J, Besmer P. Differential expression and processing of two cell associated forms of the kit-ligand: KL-1 and KL-2. Mol Biol Cell. 1992;3:349-62 pubmed
    The c-kit ligand, KL, and its receptor, the proto-oncogene c-kit are encoded, respectively, at the steel (Sl) and white spotting (W) loci of the mouse...
  3. Rapley E, Turnbull C, Al Olama A, Dermitzakis E, Linger R, Huddart R, et al. A genome-wide association study of testicular germ cell tumor. Nat Genet. 2009;41:807-10 pubmed publisher
    ..50 (95% CI = 1.28-1.75), P = 10(-13)) and chromosome 12 (OR = 2.55 (95% CI = 2.05-3.19), P = 10(-31)). KITLG, encoding the ligand for the receptor tyrosine kinase KIT, which has previously been implicated in the ..
  4. Han Z, Ren H, Zhao H, Chi Y, Chen K, Zhou B, et al. Hypoxia-inducible factor (HIF)-1 alpha directly enhances the transcriptional activity of stem cell factor (SCF) in response to hypoxia and epidermal growth factor (EGF). Carcinogenesis. 2008;29:1853-61 pubmed publisher
    b>Stem cell factor (SCF) plays important roles in tumor growth and angiogenesis. However, its regulatory mechanism remains largely undefined...
  5. Galan J, De Felici M, Buch B, Rivero M, Segura A, Royo J, et al. Association of genetic markers within the KIT and KITLG genes with human male infertility. Hum Reprod. 2006;21:3185-92 pubmed
    There is much evidence involving the KIT tyrosine kinase receptor and its ligand KITLG in the survival and proliferation of germ cells...
  6. Zeron Medina J, Wang X, Repapi E, Campbell M, Su D, Castro Giner F, et al. A polymorphic p53 response element in KIT ligand influences cancer risk and has undergone natural selection. Cell. 2013;155:410-22 pubmed publisher
    ..p53-binding site and establish its influence on the ability of p53 to bind to and regulate transcription of the KITLG gene...
  7. Levina V, Marrangoni A, Wang T, Parikh S, Su Y, Herberman R, et al. Elimination of human lung cancer stem cells through targeting of the stem cell factor-c-kit autocrine signaling loop. Cancer Res. 2010;70:338-46 pubmed publisher
    ..In this study, we provide evidence that blocking stem cell factor (SCF)-c-kit signaling is sufficient to inhibit CSC proliferation and survival promoted by chemotherapy...
  8. Jiang X, Gurel O, Mendiaz E, Stearns G, Clogston C, Lu H, et al. Structure of the active core of human stem cell factor and analysis of binding to its receptor kit. EMBO J. 2000;19:3192-203 pubmed
    b>Stem cell factor (SCF) is an early-acting hematopoietic cytokine that elicits multiple biological effects. SCF is dimeric and occurs in soluble and membrane-bound forms...
  9. Pircher T, Geiger J, Zhang D, Miller C, Gaines P, Wojchowski D. Integrative signaling by minimal erythropoietin receptor forms and c-Kit. J Biol Chem. 2001;276:8995-9002 pubmed
    Erythroid homeostasis depends critically upon erythropoietin (Epo) and stem cell factor cosignaling in late progenitor cells...

More Information

Publications94

  1. Dentelli P, Rosso A, Balsamo A, Colmenares Benedetto S, Zeoli A, Pegoraro M, et al. C-KIT, by interacting with the membrane-bound ligand, recruits endothelial progenitor cells to inflamed endothelium. Blood. 2007;109:4264-71 pubmed
    ..Thus, our results provide new insights into the mechanisms underlying EPC recruitment and the bases for novel strategies to hinder pathological angiogenesis. ..
  2. Ronnstrand L. Signal transduction via the stem cell factor receptor/c-Kit. Cell Mol Life Sci. 2004;61:2535-48 pubmed
    Together with its ligand, stem cell factor, the receptor tyrosine kinase c-Kit is a key controlling receptor for a number of cell types, including hematopoietic stem cells, mast cells, melanocytes and germ cells...
  3. Broudy V. Stem cell factor and hematopoiesis. Blood. 1997;90:1345-64 pubmed
  4. Turnbull C, Rapley E, Seal S, Pernet D, Renwick A, Hughes D, et al. Variants near DMRT1, TERT and ATF7IP are associated with testicular germ cell cancer. Nat Genet. 2010;42:604-7 pubmed publisher
    ..Finally, we identified a locus on chromosome 9 (rs755383, OR=1.37, P=1.12x10(-23)), containing the sex determination gene DMRT1, which has been linked to teratoma susceptibility in mice. ..
  5. Sun L, Hui A, Su Q, Vortmeyer A, Kotliarov Y, Pastorino S, et al. Neuronal and glioma-derived stem cell factor induces angiogenesis within the brain. Cancer Cell. 2006;9:287-300 pubmed
    b>Stem cell factor (SCF) is overexpressed by neurons following brain injury as well as by glioma cells; however, its role in gliomagenesis remains unclear...
  6. Kratz C, Han S, Rosenberg P, Berndt S, Burdett L, Yeager M, et al. Variants in or near KITLG, BAK1, DMRT1, and TERT-CLPTM1L predispose to familial testicular germ cell tumour. J Med Genet. 2011;48:473-6 pubmed publisher
    ..The study genotyped 106 single nucleotide polymorphisms (SNPs) in four regions (BAK1, DMRT1, KITLG, TERT-CLPTM1L) previously identified from genome-wide association studies of TGCT, including risk single ..
  7. Da Silva C, Kassel O, Lebouquin R, Lacroix E, Frossard N. Paradoxical early glucocorticoid induction of stem cell factor (SCF) expression in inflammatory conditions. Br J Pharmacol. 2004;141:75-84 pubmed
    1. Stem cell factor (SCF) is a major growth factor for mast cells, promoting their differentiation and chemotaxis...
  8. Pedersen M, Löfstedt T, Sun J, Holmquist Mengelbier L, Påhlman S, Ronnstrand L. Stem cell factor induces HIF-1alpha at normoxia in hematopoietic cells. Biochem Biophys Res Commun. 2008;377:98-103 pubmed publisher
    Signaling by the receptor for stem cell factor (SCF), c-Kit, is of major importance for hematopoiesis, melanogenesis and reproduction, and the biological responses are commonly proliferation and cell survival...
  9. Dalgaard M, Weinhold N, Edsgard D, Silver J, Pers T, Nielsen J, et al. A genome-wide association study of men with symptoms of testicular dysgenesis syndrome and its network biology interpretation. J Med Genet. 2012;49:58-65 pubmed publisher
    ..The incidence of these disorders has increased over the last few decades, and testicular cancer now affects 1% of the Danish and Norwegian male population...
  10. Wang X, Ren H, Zhao T, Chen J, Sun W, Sun Y, et al. Stem cell factor is a novel independent prognostic biomarker for hepatocellular carcinoma after curative resection. Carcinogenesis. 2014;35:2283-90 pubmed publisher
    b>Stem cell factor (SCF), a ligand of c-kit, is a hematopoietic growth factor. Uncontrolled activity of SCF/c-kit signaling pathway contributes to the formation of a variety of human malignancies...
  11. Mashour G, Driever P, Hartmann M, Drissel S, Zhang T, Scharf B, et al. Circulating growth factor levels are associated with tumorigenesis in neurofibromatosis type 1. Clin Cancer Res. 2004;10:5677-83 pubmed
    ..Concentrations of midkine (MK) and stem cell factor, but not epidermal growth factor, were substantially increased in serum of NF1 patients when compared with ..
  12. Krasagakis K, Kruger Krasagakis S, Eberle J, Tsatsakis A, Tosca A, Stathopoulos E. Co-expression of KIT receptor and its ligand stem cell factor in Merkel cell carcinoma. Dermatology. 2009;218:37-43 pubmed publisher
    ..Merkel cell carcinoma (MCC) is a rare KIT-positive cutaneous tumor. We investigated the co-expression of KIT and its ligand stem cell factor (SCF) in MCC.
  13. Zhang M, Ma Q, Hu H, Zhang D, Li J, Ma G, et al. Stem cell factor/c-kit signaling enhances invasion of pancreatic cancer cells via HIF-1? under normoxic condition. Cancer Lett. 2011;303:108-17 pubmed publisher
    The SCF/c-kit signaling plays an important role in invasion of c-kit-expressing tumor cells, however, the molecular mechanisms have not been studied yet...
  14. Ferlin A, Pengo M, Pizzol D, Carraro U, Frigo A, Foresta C. Variants in KITLG predispose to testicular germ cell cancer independently from spermatogenic function. Endocr Relat Cancer. 2012;19:101-8 pubmed publisher
    ..Genome-wide studies identified that TGCT susceptibility is associated with KITLG (c-KIT ligand), which regulates the formation of primordial germ cells, from which TGCT is believed to arise and ..
  15. Gibbs B, Yasinska I, Oniku A, Sumbayev V. Effects of stem cell factor on hypoxia-inducible factor 1 alpha accumulation in human acute myeloid leukaemia and LAD2 mast cells. PLoS ONE. 2011;6:e22502 pubmed publisher
    b>Stem cell factor (SCF) is a hematopoietic growth factor that exerts its activity by signalling through the tyrosine kinase receptor known as Kit or CD117...
  16. Hirano K, Shishido Hara Y, Kitazawa A, Kojima K, Sumiishi A, Umino M, et al. Expression of stem cell factor (SCF), a KIT ligand, in gastrointestinal stromal tumors (GISTs): a potential marker for tumor proliferation. Pathol Res Pract. 2008;204:799-807 pubmed publisher
    ..Some mesenchymal and epithelial tumors have been reported to co-express KIT and its ligand, stem cell factor (SCF), for autonomous proliferation by the autocrine mechanism...
  17. Kanetsky P, Mitra N, Vardhanabhuti S, Li M, Vaughn D, Letrero R, et al. Common variation in KITLG and at 5q31.3 predisposes to testicular germ cell cancer. Nat Genet. 2009;41:811-5 pubmed publisher
    ..a genome-wide scan among 277 TGCT cases and 919 controls and found that seven markers at 12p22 within KITLG (c-KIT ligand) reached genome-wide significance (P < 5.0 x 10(-8) in discovery)...
  18. Zhang Z, Zhang R, Joachimiak A, Schlessinger J, Kong X. Crystal structure of human stem cell factor: implication for stem cell factor receptor dimerization and activation. Proc Natl Acad Sci U S A. 2000;97:7732-7 pubmed
    b>Stem cell factor (SCF) plays important roles in hematopoiesis and the survival, proliferation, and differentiation of mast cells, melanocytes, and germ cells...
  19. Maraldi T, Fiorentini D, Prata C, Landi L, Hakim G. Glucose-transport regulation in leukemic cells: how can H2O2 mimic stem cell factor effects?. Antioxid Redox Signal. 2007;9:271-9 pubmed
    In leukemic cells, glucose transport is activated by SCF and H2O2 through a common signal cascade involving Akt, PLCgamma, Syk, and the Src family, in this order...
  20. Matsui J, Wakabayashi T, Asada M, Yoshimatsu K, Okada M. Stem cell factor/c-kit signaling promotes the survival, migration, and capillary tube formation of human umbilical vein endothelial cells. J Biol Chem. 2004;279:18600-7 pubmed
    ..c-kit is expressed in mature endothelial cells, but its role there is unclear. Stem cell factor, a c-kit ligand, dose-dependently promoted survival, migration, and capillary tube formation of human ..
  21. Lefevre G, Glotin A, Calipel A, Mouriaux F, Tran T, Kherrouche Z, et al. Roles of stem cell factor/c-Kit and effects of Glivec/STI571 in human uveal melanoma cell tumorigenesis. J Biol Chem. 2004;279:31769-79 pubmed
    ..Mouriaux, F., Eychene, A., and Mascarelli, F. (2003) J. Biol. Chem. 278, 42409-42418). We have shown that stem cell factor (SCF) is involved in the proliferation of normal uveal melanocytes and that c-Kit is expressed in 75% of ..
  22. Xiao H, Xiong L, Song X, Jin P, Chen L, Chen X, et al. Angelica sinensis Polysaccharides Ameliorate Stress-Induced Premature Senescence of Hematopoietic Cell via Protecting Bone Marrow Stromal Cells from Oxidative Injuries Caused by 5-Fluorouracil. Int J Mol Sci. 2017;18: pubmed publisher
    ..Oxidative damage of HS-5 cells resulted in declined hematopoietic stimulating factors including stem cell factor (SCF), stromal cell-derived factor (SDF), and granulocyte-macrophage colony-stimulating factor (GM-CSF), ..
  23. Hsiao C, Ji A, Chang C, Cheng C, Lee L, Ho J. Local injection of mesenchymal stem cells protects testicular torsion-induced germ cell injury. Stem Cell Res Ther. 2015;6:113 pubmed publisher
    ..Western blot analysis for superoxide dismutase 2, Bax, Caspase-3, human insulin growth factor-1 and human stem cell factor, malondialdehyde (MDA) assay in testis and plasma, hormones level including testosterone, follicle-..
  24. Lindblad O, Kazi J, Rönnstrand L, Sun J. PI3 kinase is indispensable for oncogenic transformation by the V560D mutant of c-Kit in a kinase-independent manner. Cell Mol Life Sci. 2015;72:4399-407 pubmed publisher
    ..Phosphorylation of downstream signaling proteins induced by the ligand for c-Kit, stem cell factor, was stronger in c-Kit/V560D expressing cells than in cells expressing c-kit/D816V...
  25. Zhao Y, Liu Q, Acharya P, Stengel K, Sheng Q, Zhou X, et al. High-Resolution Mapping of RNA Polymerases Identifies Mechanisms of Sensitivity and Resistance to BET Inhibitors in t(8;21) AML. Cell Rep. 2016;16:2003-16 pubmed publisher
    ..over 1,400 genes showing impaired release of promoter-proximal paused RNA polymerases, including the stem cell factor receptor tyrosine kinase KIT that is mutated in t(8;21) AML. PRO-seq also identified an enhancer 3' to KIT...
  26. Saito S, Enomoto M, Sakakura S, Ishii Y, Sudo T, Ichijo M. Localization of stem cell factor (SCF) and c-kit mRNA in human placental tissue and biological effects of SCF on DNA synthesis in primary cultured cytotrophoblasts. Biochem Biophys Res Commun. 1994;205:1762-9 pubmed
    ..homogenized human placental tissues at early and late stages of pregnancy were found to contain 40-100 pg of stem cell factor (SCF)/mg of total protein by enzyme linked immunosorbent assay...
  27. Zhang W, Shen Y, Meng Y, Gong M. Quasi-single-crystal-fiber acousto-optic Q-switched tandem dual Nd:YVO4 thin rods laser. Appl Opt. 2017;56:7512-7517 pubmed publisher
    An 888 nm pumped quasi-single-crystal-fiber (quasi-SCF) acousto-optic Q-switched Nd:YVO4 laser is experimentally demonstrated for the first time, where two closely jointed crystals with different side surface styles serve as ..
  28. Borriello A, Naviglio S, Bencivenga D, Caldarelli I, Tramontano A, Speranza M, et al. Histone Deacetylase Inhibitors Increase p27(Kip1) by Affecting Its Ubiquitin-Dependent Degradation through Skp2 Downregulation. Oxid Med Cell Longev. 2016;2016:2481865 pubmed publisher
    ..p27(Kip1) removal requires a preliminary ubiquitination step due to the Skp2-SCF E3 ligase complex...
  29. Rao T, Gao R, Takada S, Al Abo M, Chen X, Walters K, et al. Novel TDP2-ubiquitin interactions and their importance for the repair of topoisomerase II-mediated DNA damage. Nucleic Acids Res. 2016;44:10201-10215 pubmed
    ..However, the absence of the highly conserved MGF motif and the presence of a fourth α-helix make TDP2 UBA distinct from other known UBAs...
  30. Shimoto M, Sugiyama T, Nagasawa T. Numerous niches for hematopoietic stem cells remain empty during homeostasis. Blood. 2017;129:2124-2131 pubmed publisher
    ..Additionally, stem cell factor that is produced by CXC chemokine ligand 12-abundant reticular cells is involved in HSC engraftment...
  31. Xu J, Nie H, Nie K, Jin W. Fixed-pattern noise correction method based on improved moment matching for a TDI CMOS image sensor. J Opt Soc Am A Opt Image Sci Vis. 2017;34:1500-1510 pubmed publisher
    In this paper, an improved moment matching method based on a spatial correlation filter (SCF) and bilateral filter (BF) is proposed to correct the fixed-pattern noise (FPN) of a time-delay-integration CMOS image sensor (TDI-CIS)...
  32. Talenti A, Bertolini F, Williams J, Moaeen ud Din M, Frattini S, Coizet B, et al. Genomic analysis suggests KITLG is responsible for a roan pattern in two Pakistani goat breeds. J Hered. 2017;: pubmed publisher
    ..The molecular mechanisms and inheritance that underlie this pattern are known for some species and the KITLG gene has been shown associated with this phenotype...
  33. Zewdu R, Risolino M, Barbulescu A, Ramalingam P, Butler J, Selleri L. Spleen hypoplasia leads to abnormal stress hematopoiesis in mice with loss of Pbx homeoproteins in splenic mesenchyme. J Anat. 2016;229:153-69 pubmed publisher
    ..following sublethal irradiation displayed significant downregulation of multiple cytokine-encoding genes, including KitL/SCF, Cxcl12/SDF-1, IL-3, IL-4, GM-CSF/Csf2 IL-10, and Igf-1, compared with controls...
  34. Dionizio A, Melo C, Sabino Arias I, Ventura T, Leite A, Souza S, et al. Chronic treatment with fluoride affects the jejunum: insights from proteomics and enteric innervation analysis. Sci Rep. 2018;8:3180 pubmed publisher
    ..Wistar rats received water containing 0, 10 or 50 mgF/L during 30 days...
  35. Yin J, Liang Y, Wang D, Yan Z, Yin H, Wu D, et al. Naringenin induces laxative effects by upregulating the expression levels of c-Kit and SCF, as well as those of aquaporin 3 in mice with loperamide-induced constipation. Int J Mol Med. 2018;41:649-658 pubmed publisher
    ..factor (GDNF), transient receptor potential vanilloid 1 (TRPV1), nitric oxide synthase (NOS), c-Kit, stem cell factor (SCF) and aquaporin 3 (AQP3) were examined by western blot analysis and RT-PCR analysis...
  36. Jia F, Wang C, Huang J, Yang G, Wu C, Zheng C. SCF E3 ligase PP2-B11 plays a positive role in response to salt stress in Arabidopsis. J Exp Bot. 2015;66:4683-97 pubmed publisher
    Skp1-Cullin-F-box (SCF) E3 ligases are essential to the post-translational regulation of many important factors involved in cellular signal transduction...
  37. Barbosa S, Carreira S, Bailey D, Abaitua F, O Hare P. Phosphorylation and SCF-mediated degradation regulate CREB-H transcription of metabolic targets. Mol Biol Cell. 2015;26:2939-54 pubmed publisher
    ..that this region is subject to multiple phosphorylations, which regulate CREB-H stability by targeting it to the SCF(Fbw1a) E3 ubiquitin ligase...
  38. Yoon K, Son Y, Choi Y, Kim J, Cho J. Fibroblast growth factor 2 supports osteoblastic niche cells during hematopoietic homeostasis recovery after bone marrow suppression. Cell Commun Signal. 2017;15:25 pubmed publisher
    ..cells isolated from 5FU-treated mice showed increased expression of the niche-related genes Sdf-1, Jagged-1, Scf, N-cad, Angpt1 and Vcam-1 and the osteoblast marker genes Osx, Opn, Runx2, and Alp, indicating that BM stress upon ..
  39. Manne R, Agrawal Y, Bargale A, Patel A, Paul D, Gupta N, et al. A MicroRNA/Ubiquitin Ligase Feedback Loop Regulates Slug-Mediated Invasion in Breast Cancer. Neoplasia. 2017;19:483-495 pubmed publisher
    ..The tumor suppressor protein FBXO31 is a component of the SCF E3 ubiquitin ligase and is required to arrest cells at G1 following genotoxic stresses...
  40. Bussell R, Nichol R, Toumba K. Fluoride levels in UK infant milks. Eur Arch Paediatr Dent. 2016;17:177-85 pubmed publisher
    ..017 ppmF) products. The daily fluoride contribution from infant milks was low; 0.0034 mgF/kg body weight per day was estimated between birth and 6 months of age, further decreasing as intake of infant ..
  41. Sun Y, Zhang Y, Zhang D, Xu C, Chen S, Zhang J, et al. XCI-escaping gene KDM5C contributes to ovarian development via downregulating miR-320a. Hum Genet. 2017;136:227-239 pubmed publisher
    ..In addition, we demonstrated that KITLG, an essential gene for ovarian development and primordial germ cell survival, was a direct target of miR-320a and ..
  42. Tam I, Ng C, Tam S, Lau H. Novel six-week protocol for generating functional human connective tissue-type (MCTC) mast cells from buffy coats. Inflamm Res. 2017;66:25-37 pubmed publisher
    ..cells isolated from fresh human buffy coats were sequentially cultured with different combinations of SCF, IL-6, IL-3, IL-9 and IL-4 under selected culturing conditions and time periods...
  43. Perumal D, Pillai S, Nguyen J, Schaal C, Coppola D, Chellappan S. Nicotinic acetylcholine receptors induce c-Kit ligand/Stem Cell Factor and promote stemness in an ARRB1/ β-arrestin-1 dependent manner in NSCLC. Oncotarget. 2014;5:10486-502 pubmed
    ..Among the identified genes, SCF (Stem cell factor) strongly differentiated smokers from non-smokers in the Director's Challenge Set expression data and its ..
  44. Wojda U, Leigh K, Njoroge J, Jackson K, Natarajan B, Stitely M, et al. Fetal hemoglobin modulation during human erythropoiesis: stem cell factor has "late" effects related to the expression pattern of CD117. Blood. 2003;101:492-7 pubmed
    ..Among the 12 erythroid growth-promoting cytokines tested, stem cell factor (SCF) at a concentration of 50 ng/mL resulted in the most significant increase in cell proliferation and HbF ..
  45. Krieg A, Schulte Am Esch J, Schmelzle M, Tustas R, el Karmi A, Hosch S, et al. Stem cell factor levels do increase in patients subsequent to hepatectomy with the extent of parenchymal loss. Transplant Proc. 2006;38:3556-8 pubmed
  46. Lee S, Kim W, Ko C, Ryu W. Hepatitis B virus X protein enhances Myc stability by inhibiting SCF(Skp2) ubiquitin E3 ligase-mediated Myc ubiquitination and contributes to oncogenesis. Oncogene. 2016;35:1857-67 pubmed publisher
    The stability of Myc oncoprotein is regulated by Skp/cullin/F-box (SCF) ubiquitin E3 ligase, in particular, via either SCF(Skp2) or SCF(Fbw7) ubiquitin E3 ligases...
  47. Vavrova J, Vokurkova D, Marekova M, Blaha M, Jebavy L, Filip S. Antiapoptotic cytokine IL-3 + SCF + FLT3L influence on proliferation of gamma-irradiated AC133+/CD34+ progenitor cells. Folia Biol (Praha). 2002;48:51-7 pubmed
    ..We proved a high expansion efficiency of cytokine combination SCF + IL-3 + FLT3L in comparison with the combination SCF + IL-3 + IL-11 in both, non-irradiated cells and cells ..
  48. von Kopylow K, Schulze W, Salzbrunn A, Spiess A. Isolation and gene expression analysis of single potential human spermatogonial stem cells. Mol Hum Reprod. 2016;22:229-39 pubmed publisher
    ..Furthermore, isolated cells exhibit strong immunocytochemical staining for the stem cell factor UTF1 and are viable...
  49. Walter D, Hoffmann S, Komseli E, Rappsilber J, Gorgoulis V, Sørensen C. SCF(Cyclin F)-dependent degradation of CDC6 suppresses DNA re-replication. Nat Commun. 2016;7:10530 pubmed publisher
    ..Here we report that the SCF(Cyclin F) ubiquitin ligase complex prevents DNA re-replication by targeting CDC6 for proteasomal degradation late ..
  50. Kraiem H, Zouari F, Abderrazek R, Manon Y, El Ayeb M, Fillaudeau L, et al. Two-Dimensional Isoelectric Focusing OFFGEL, Micro-fluidic Lab-on-Chip Electrophoresis and FTIR for assessment of long-term stability of rhG-CSF formulation. IEEE Trans Nanobioscience. 2017;:1 pubmed publisher
    ..Indeed, changes in charge from glutamine deamination may alter the way rhG-SCF will refold and the structure of resulting molecule...
  51. He Y, Zeng H, Yu Y, Zhang J, Liu Q, Yang B. Resveratrol improved detrusor fibrosis induced by mast cells during progression of chronic prostatitis in rats. Eur J Pharmacol. 2017;815:495-500 pubmed publisher
    ..Western blot and immunohistochemical staining are used to examine the expression of c-kit, SCF?tryptase, TGF-?, Wnt and ?-SMA...
  52. Schrimpf C, Wrede C, Glage S, Hegermann J, Backhaus S, Blasczyk R, et al. Differentiation of induced pluripotent stem cell-derived neutrophil granulocytes from common marmoset monkey (Callithrix jacchus). Transfusion. 2017;57:60-69 pubmed publisher
    ..growth factor receptor-2 (VEGFR2)- cells were sorted, treated with interleukin (IL-3), thrombopoietin, and stem cell factor for 20 days and further cultivated with granulocyte-colony-stimulating factor (G-CSF) and IL-3 for 10 days...
  53. Geissler E, Liao M, Brook J, Martin F, Zsebo K, Housman D, et al. Stem cell factor (SCF), a novel hematopoietic growth factor and ligand for c-kit tyrosine kinase receptor, maps on human chromosome 12 between 12q14.3 and 12qter. Somat Cell Mol Genet. 1991;17:207-14 pubmed
    Recently a novel hematopoietic growth factor, stem cell factor (SCF), was cloned and demonstrated to be the ligand for the c-kit tyrosine kinase receptor...
  54. Takenaka Y, Hoshino Y, Nakajima H, Hayashi N, Kawashima M, Imokawa G. Paracrine cytokine mechanisms underlying the hyperpigmentation of seborrheic keratosis in covered skin areas. J Dermatol. 2013;40:533-42 pubmed publisher
    We previously reported that increased expression of the endothelin (EDN)1/EDNB receptor (EDNBR) as well as the stem cell factor (SCF)/SCF receptor (c-KIT) linkages is mainly responsible for the activation of melanocytes in the epidermal ..
  55. Galper J, Rayner S, Hogan A, Fifita J, Lee A, Chung R, et al. Cyclin F: A component of an E3 ubiquitin ligase complex with roles in neurodegeneration and cancer. Int J Biochem Cell Biol. 2017;89:216-220 pubmed publisher
    ..Cyclin F, encoded by CCNF, is the substrate recognition component of the Skp1-Cul1-F-box E3 ubiquitin ligase complex, SCFcyclin F...
  56. Sulem P, Gudbjartsson D, Stacey S, Helgason A, Rafnar T, Magnusson K, et al. Genetic determinants of hair, eye and skin pigmentation in Europeans. Nat Genet. 2007;39:1443-52 pubmed
    ..A variant in SLC24A4 is associated with eye and hair color, a variant near KITLG is associated with hair color, two coding variants in TYR are associated with eye color and freckles, and a ..
  57. Lin G, Tseng H, Yang C, Hou M, Chuang L, Tai H, et al. Combinational polymorphisms of seven CXCL12-related genes are protective against breast cancer in Taiwan. OMICS. 2009;13:165-72 pubmed publisher
  58. Whisner C, Martin B, Nakatsu C, Story J, MacDonald Clarke C, McCabe L, et al. Soluble Corn Fiber Increases Calcium Absorption Associated with Shifts in the Gut Microbiome: A Randomized Dose-Response Trial in Free-Living Pubertal Females. J Nutr. 2016;146:1298-306 pubmed publisher
    Soluble corn fiber (SCF; 12 g fiber/d) is shown to increase calcium absorption efficiency, associated with shifts in the gut microbiota in adolescent males and females who participated in a controlled feeding study...
  59. Collart C, Smith J, Zegerman P. Chk1 Inhibition of the Replication Factor Drf1 Guarantees Cell-Cycle Elongation at the Xenopus laevis Mid-blastula Transition. Dev Cell. 2017;42:82-96.e3 pubmed publisher
    ..we show in Xenopus laevis that developmental activation of the checkpoint kinase Chk1 at the MBT results in the SCFβ-TRCP-dependent degradation of a limiting replication initiation factor Drf1...
  60. Lim J, Lima P, Salehi R, Lee D, Tsang B. Regulation of androgen receptor signaling by ubiquitination during folliculogenesis and its possible dysregulation in polycystic ovarian syndrome. Sci Rep. 2017;7:10272 pubmed publisher
    ..the possible dysregulation in the expression and actions of growth differentiation factor 9 (GDF9) and kit-ligand (Kitlg) in a chronic androgenized PCOS rat model...
  61. Vasiliades G, Kopanakis N, Vasiloglou M, Zografos G, Margaris H, Masselou K, et al. Role of the hematopoietic cytokines SCF, IL-3, GM-CSF and M-CSF in the diagnosis of pancreatic and ampullary cancer. Int J Biol Markers. 2012;27:e186-94 pubmed publisher
    ..Previous studies have demonstrated altered levels of hematopoietic cytokines in the serum of patients with different types of cancer...
  62. Micu B, Andercou O, Micu C, Militaru V, Jeican I, Bungărdean C, et al. Spontaneous cholecystocutaneous fistula as a primary manifestation of gallbladder adenocarcinoma associated with gallbladder lithiasis - case report. Rom J Morphol Embryol. 2017;58:575-583 pubmed
    Spontaneous cholecystocutaneous fistula (SCF) is a rare complication of neglected calculous biliary disease and also an extremely rare complication of gallbladder neoplasm...
  63. Serimbetov Z, Baxter N, Cliff M, Waltho J. 1H, 15N, 13C backbone resonance assignments of human phosphoglycerate kinase in a transition state analogue complex with ADP, 3-phosphoglycerate and magnesium trifluoride. Biomol NMR Assign. 2017;11:251-256 pubmed publisher
    ..X-ray crystallography using magnesium trifluoride (MgF3-) as a isoelectronic and near-isosteric mimic of the transferring phosphoryl group (PO3<..
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    ..the 13 mapped genes: cen-->COL2A1-->(VDR-D12S15)-->(D12S17-D12S4++ +-D12S14-D12S6)-->D12S8-->(IAPP-MGF- D12S7-D12S12)-->IGF1-->qter...
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    ..lentigos is associated with the increased production of melanogenic cytokines, such as endothelin (EDN)-1 and stem cell factor (SCF), by keratinocytes in those areas of the skin...
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    Low subjective cognitive function (SCF), which is associated with APOE4 genotype, adversely impacts quality of life and has predicted clinical dementia...
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    ..The gene products of these loci are a peptide growth factor, called here stem cell factor (SCF), and its tyrosine kinase receptor, the proto-oncogene c-kit...
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    ..Melatonin increased the expression of stem cell factor and insulin-like growth factor-1 and decreased estrogen synthesis in Sertoli cells...
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    ..transiently treated with a pharmacological concentration of dasatinib, for a short time in the presence of stem cell factor. A dasatinib resistant counterpart (K562 RES) was developed...
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    ..for the presence of mast cells using toluidine blue staining and immunohistochemical detection of CD117 (stem cell factor receptor)...
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    ..Western blotting and immunohistochemical staining examined the expression level of C-kit, stem cell factor (SCF), Sirt1, apoptosis associated proteins...
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    b>Stem cell factor (SCF), an important stem cell cytokine, has multiple functions. Fibroblasts (FBs), mature mast cells, endothelial cells (ECs), and eosinophil granulocytes can produce SCF in the inflammatory process...
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    ..Leydig cell number initially increased exponentially but slowed toward 19 wk. Transcripts encoding Sertoli (KITL, FGF9, SOX9, FSHR, WT1) and germ (CKIT, TFAP2C) cell-specific products increased per testis through the second ..
  74. Cordeiro Gomes A, Hara T, Lim V, Herndler Brandstetter D, Nevius E, Sugiyama T, et al. Hematopoietic Stem Cell Niches Produce Lineage-Instructive Signals to Control Multipotent Progenitor Differentiation. Immunity. 2016;45:1219-1231 pubmed publisher
    ..IL-7+ cells expressed CXCL12 and the cytokine SCF, were mesenchymal progenitors capable of differentiation into osteoblasts and adipocytes, and comprised a minor ..
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    ..gastric fluid (SGF) and simulated intestinal fluid (SIF) prior to drug release in simulated colonic fluid (SCF) to a higher extent than homogenized microparticles...
  76. Lee Y, Jung J, Cho K, Lee S, Park J, Oh I, et al. Increased SCF/c-kit by hypoxia promotes autophagy of human placental chorionic plate-derived mesenchymal stem cells via regulating the phosphorylation of mTOR. J Cell Biochem. 2013;114:79-88 pubmed publisher
    ..The expression of self-renewal markers (e.g., Oct4, Nanog, Sox2) was assessed in both cell lines. PI3K and stem cell factor (SCF) expression gradually increased in CP-MSCs but were markedly downregulated in BM-MSCs by hypoxia...
  77. Klimchenko O, Di Stefano A, Geoerger B, Hamidi S, Opolon P, Robert T, et al. Monocytic cells derived from human embryonic stem cells and fetal liver share common differentiation pathways and homeostatic functions. Blood. 2011;117:3065-75 pubmed publisher
    ..Trophic and immunosuppressive functions of M2-polarized macrophages link fetus and tumor development, and hESCs offer a valuable experimental model for in vitro studies of mechanisms sustaining these processes. ..
  78. Rolland A, Guyon L, Gill M, Cai Y, Banchereau J, McClain K, et al. Increased blood myeloid dendritic cells and dendritic cell-poietins in Langerhans cell histiocytosis. J Immunol. 2005;174:3067-71 pubmed
    ..Finally, patients with bone lesions had relatively higher levels of M-CSF and of stem cell factor. Thus, early hemopoietic cytokines such as FLT3-L, stem cell factor, and M-CSF maybe relevant in LCH ..
  79. Enomoto A, Yoshihisa Y, Yamakoshi T, Ur Rehman M, Norisugi O, Hara H, et al. UV-B radiation induces macrophage migration inhibitory factor-mediated melanogenesis through activation of protease-activated receptor-2 and stem cell factor in keratinocytes. Am J Pathol. 2011;178:679-87 pubmed publisher
    ..In addition, we showed that MIF stimulated stem cell factor (SCF) release in keratinocytes; however, MIF had no effect on the release of endothelin-1 or prostaglandin E2 ..
  80. Li J, Goodyer C, Fellows F, Wang R. Stem cell factor/c-Kit interactions regulate human islet-epithelial cluster proliferation and differentiation. Int J Biochem Cell Biol. 2006;38:961-72 pubmed
    b>Stem cell factor (SCF), a progenitor cell growth factor, binds to and activates the c-Kit receptor tyrosine kinase, which is critical for early stem cell differentiation in haematopoiesis and gametogenesis...
  81. Lee J, Park C, Jang S, Kim J, Kim S, Song S, et al. Tolerogenic dendritic cells are efficiently generated using minocycline and dexamethasone. Sci Rep. 2017;7:15087 pubmed publisher
    ..was generated when minocycline and dexamethasone were used together with granulocyte colony-stimulating factor (GM-SCF) and IL-4...
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    ..regarding the final differentiation of NCC into neurons and glial cells with neurons subsequently excreting stem cell factor (SCF) and other signalling molecules...
  83. Kasamatsu S, Hachiya A, Higuchi K, Ohuchi A, Kitahara T, Boissy R. Production of the soluble form of KIT, s-KIT, abolishes stem cell factor-induced melanogenesis in human melanocytes. J Invest Dermatol. 2008;128:1763-72 pubmed publisher
    The signaling of stem cell factor (SCF) and its receptor KIT (membrane-bound KIT; m-KIT) plays an important role in melanocyte development, survival, proliferation, and melanogenesis...
  84. Debes J, van Tilborg M, Groothuismink Z, Hansen B, Schulze zur Wiesch J, von Felden J, et al. Levels of Cytokines in Serum Associate With Development of Hepatocellular Carcinoma in Patients With HCV Infection Treated With Direct-Acting Antivirals. Gastroenterology. 2018;154:515-517.e3 pubmed publisher
    ..A panel of 9 cytokines, measured in serum before treatment (MIG, IL22, TRAIL, APRIL, VEGF, IL3, TWEAK, SCF, IL21), identified patients who developed de novo HCC with an area under the receiver operating characteristic ..
  85. Kaczmarek M, Lagiedo M, Masztalerz A, Kozlowska M, Nowicka A, Brajer B, et al. Concentrations of SP-A and HSP70 are associated with polarization of macrophages in pleural effusions of non-small cell lung cancer. Immunobiology. 2018;223:200-209 pubmed publisher
    ..In 34 PE samples, we estimated concentration of SP-A, Hsp70, IL-6, IL-18, G-CSF, M-CSF, SCF, SDF1?, VEGF as well as the fraction of macrophages and their pattern of polarization...