KISS1R

Summary

Gene Symbol: KISS1R
Description: KISS1 receptor
Alias: AXOR12, CPPB1, GPR54, HH8, HOT7T175, KISS-1R, kiSS-1 receptor, G protein-coupled receptor 54, G-protein coupled receptor OT7T175, hypogonadotropin-1, kisspeptins receptor, metastin receptor
Species: human
Products:     KISS1R

Top Publications

  1. Kotani M, Detheux M, Vandenbogaerde A, Communi D, Vanderwinden J, Le Poul E, et al. The metastasis suppressor gene KiSS-1 encodes kisspeptins, the natural ligands of the orphan G protein-coupled receptor GPR54. J Biol Chem. 2001;276:34631-6 pubmed
    Natural peptides displaying agonist activity on the orphan G protein-coupled receptor GPR54 were isolated from human placenta...
  2. Ikeguchi M, Hirooka Y, Kaibara N. Quantitative reverse transcriptase polymerase chain reaction analysis for KiSS-1 and orphan G-protein-coupled receptor (hOT7T175) gene expression in hepatocellular carcinoma. J Cancer Res Clin Oncol. 2003;129:531-5 pubmed
    KiSS-1 has been cloned as a human metastasis suppressor gene and an orphan G-protein-coupled receptor (hOT7T175) identified as the endogenous receptor of the KiSS-1 product...
  3. Mead E, Maguire J, Kuc R, Davenport A. Kisspeptins are novel potent vasoconstrictors in humans, with a discrete localization of their receptor, G protein-coupled receptor 54, to atherosclerosis-prone vessels. Endocrinology. 2007;148:140-7 pubmed
    The G protein-coupled receptor GPR54 (also designated KISS1) is activated by cleavage products of the KiSS1 protein, the kisspeptins (KP), to act as a molecular switch for puberty...
  4. Ohtaki T, Shintani Y, Honda S, Matsumoto H, Hori A, Kanehashi K, et al. Metastasis suppressor gene KiSS-1 encodes peptide ligand of a G-protein-coupled receptor. Nature. 2001;411:613-7 pubmed
    ..which we have isolated from human placenta as the endogenous ligand of an orphan G-protein-coupled receptor (hOT7T175) and have named 'metastin'...
  5. Muir A, Chamberlain L, Elshourbagy N, Michalovich D, Moore D, Calamari A, et al. AXOR12, a novel human G protein-coupled receptor, activated by the peptide KiSS-1. J Biol Chem. 2001;276:28969-75 pubmed
    A novel human G protein-coupled receptor named AXOR12, exhibiting 81% homology to the rat orphan receptor GPR54, was cloned from a human brain cDNA library...
  6. Breuer O, Abdulhadi Atwan M, Zeligson S, Fridman H, Renbaum P, Levy Lahad E, et al. A novel severe N-terminal splice site KISS1R gene mutation causes hypogonadotropic hypogonadism but enables a normal development of neonatal external genitalia. Eur J Endocrinol. 2012;167:209-16 pubmed publisher
    Kisspeptin 1 receptor (KISS1R) gene mutations are rare but have recently become an important etiology of normosmic isolated hypogonadotropic hypogonadism (IHH).
  7. Ikeguchi M, Yamaguchi K, Kaibara N. Clinical significance of the loss of KiSS-1 and orphan G-protein-coupled receptor (hOT7T175) gene expression in esophageal squamous cell carcinoma. Clin Cancer Res. 2004;10:1379-83 pubmed
    ..Recently, KiSS-1 was cloned as a human metastasis suppressor gene, and an orphan G-protein-coupled receptor (hOT7T175) was identified as the endogenous receptor of the KiSS-1 product...
  8. Lanfranco F, Gromoll J, von Eckardstein S, Herding E, Nieschlag E, Simoni M. Role of sequence variations of the GnRH receptor and G protein-coupled receptor 54 gene in male idiopathic hypogonadotropic hypogonadism. Eur J Endocrinol. 2005;153:845-52 pubmed
    ..of mutations of the gonadotropin-releasing hormone receptor (GnRHR) and of the G protein-coupled receptor 54 (GPR54) genes in normosmic idiopathic hypogonadotropic hypogonadism (IHH)...
  9. Clements M, McDonald T, Wang R, Xie G, O Dowd B, George S, et al. FMRFamide-related neuropeptides are agonists of the orphan G-protein-coupled receptor GPR54. Biochem Biophys Res Commun. 2001;284:1189-93 pubmed
    ..and determined the coding sequences of human and mouse orthologs of the rat orphan G-protein-coupled receptor GPR54. Mouse and rat GPR54 are nearly 95% identical to each other, and both are approximately 85% identical to human ..

More Information

Publications107 found, 100 shown here

  1. Seminara S, Messager S, Chatzidaki E, Thresher R, Acierno J, Shagoury J, et al. The GPR54 gene as a regulator of puberty. N Engl J Med. 2003;349:1614-27 pubmed
    ..pubertal development (idiopathic hypogonadotropic hypogonadism) was examined for mutations in a candidate gene, GPR54, which encodes a G protein-coupled receptor...
  2. Lee D, Nguyen T, O Neill G, Cheng R, Liu Y, Howard A, et al. Discovery of a receptor related to the galanin receptors. FEBS Lett. 1999;446:103-7 pubmed
    We report the isolation of a cDNA clone named GPR54, which encodes a novel G protein-coupled receptor (GPCR). A PCR search of rat brain cDNA retrieved a clone partially encoding a GPCR...
  3. Janneau J, Maldonado Estrada J, Tachdjian G, Miran I, Motté N, Saulnier P, et al. Transcriptional expression of genes involved in cell invasion and migration by normal and tumoral trophoblast cells. J Clin Endocrinol Metab. 2002;87:5336-9 pubmed
    ..These transcriptional expression profiles are in favor of a predominant role of INSL4, KiSS-1 and KiSS-1R in the control of the invasive and migratory properties of trophoblast cells. ..
  4. Nimri R, Lebenthal Y, Lazar L, Chevrier L, Phillip M, Bar M, et al. A novel loss-of-function mutation in GPR54/KISS1R leads to hypogonadotropic hypogonadism in a highly consanguineous family. J Clin Endocrinol Metab. 2011;96:E536-45 pubmed publisher
    The G protein-coupled receptor 54 (GPR54), the kisspeptin receptor, is essential for stimulation of GnRH secretion and induction of puberty...
  5. de Roux N, Genin E, Carel J, Matsuda F, Chaussain J, Milgrom E. Hypogonadotropic hypogonadism due to loss of function of the KiSS1-derived peptide receptor GPR54. Proc Natl Acad Sci U S A. 2003;100:10972-6 pubmed
    ..region showed that all affected siblings of the family carried a homozygous deletion of 155 nucleotides in the GPR54 gene. This deletion encompassed the splicing acceptor site of intron 4-exon 5 junction and part of exon 5...
  6. Bilban M, Ghaffari Tabrizi N, Hintermann E, Bauer S, Molzer S, Zoratti C, et al. Kisspeptin-10, a KiSS-1/metastin-derived decapeptide, is a physiological invasion inhibitor of primary human trophoblasts. J Cell Sci. 2004;117:1319-28 pubmed
    ..These results identified Kp-10 as a novel paracrine/endocrine regulator in fine-tuning trophoblast invasion generated by the trophoblast itself. ..
  7. Seminara S. Metastin and its G protein-coupled receptor, GPR54: critical pathway modulating GnRH secretion. Front Neuroendocrinol. 2005;26:131-8 pubmed
    ..The recent identification of loss-of-function mutations in GPR54, a receptor for kisspeptin-1, has highlighted a new pathway for the timing of puberty and reproductive control.
  8. Hori A, Honda S, Asada M, Ohtaki T, Oda K, Watanabe T, et al. Metastin suppresses the motility and growth of CHO cells transfected with its receptor. Biochem Biophys Res Commun. 2001;286:958-63 pubmed
    We recently reported having identified of the ligand for an orphan G-protein-coupled receptor, hOT7T175, as the gene product (68-121)-amide of the metastasis suppressor gene KiSS-1...
  9. Navenot J, Fujii N, Peiper S. Activation of Rho and Rho-associated kinase by GPR54 and KiSS1 metastasis suppressor gene product induces changes of cell morphology and contributes to apoptosis. Mol Pharmacol. 2009;75:1300-6 pubmed publisher
    The mechanism of action of the metastasis suppressor KiSS1 and its receptor GPR54 is still incompletely characterized...
  10. Ringel M, Hardy E, Bernet V, Burch H, Schuppert F, Burman K, et al. Metastin receptor is overexpressed in papillary thyroid cancer and activates MAP kinase in thyroid cancer cells. J Clin Endocrinol Metab. 2002;87:2399 pubmed
    ..product, metastin, was recently identified as the endogenous agonist for a novel Gq/11 coupled receptor (metastin receptor)...
  11. Teles M, Trarbach E, Noel S, Guerra Junior G, Jorge A, Beneduzzi D, et al. A novel homozygous splice acceptor site mutation of KISS1R in two siblings with normosmic isolated hypogonadotropic hypogonadism. Eur J Endocrinol. 2010;163:29-34 pubmed publisher
    Loss-of-function mutations of the kisspeptin-1 receptor gene, KISS1R, have been identified in patients with normosmic isolated hypogonadotropic hypogonadism (nIHH). To investigate KISS1R defects in patients with absent or delayed puberty...
  12. Park D, Lee S, Hong S, Han A, Kwak Kim J, Yang K. Expression of Kisspeptin and its receptor GPR54 in the first trimester trophoblast of women with recurrent pregnancy loss. Am J Reprod Immunol. 2012;67:132-9 pubmed publisher
    Kisspeptin and its receptor GPR54 play a major role in trophoblast invasion...
  13. Takino T, Koshikawa N, Miyamori H, Tanaka M, Sasaki T, Okada Y, et al. Cleavage of metastasis suppressor gene product KiSS-1 protein/metastin by matrix metalloproteinases. Oncogene. 2003;22:4617-26 pubmed
    ..KiSS-1 protein is known to be processed to peptide ligand of a G-protein-coupled receptor (hOT7T175) named metastin, and suppresses metastasis of tumors expressing the receptor...
  14. Semple R, Achermann J, Ellery J, Farooqi I, Karet F, Stanhope R, et al. Two novel missense mutations in g protein-coupled receptor 54 in a patient with hypogonadotropic hypogonadism. J Clin Endocrinol Metab. 2005;90:1849-55 pubmed
    ..We examined the genes encoding GPR54 and its putative endogenous ligand, kisspeptin-1, for mutations in a cohort of 30 patients with normosmic HH or ..
  15. Yue Z, Yu M, Zhang X, Wang J, Ru S. The anti-androgenic effect of chronic exposure to semicarbazide on male Japanese flounder (Paralichthys olivaceus) and its potential mechanisms. Comp Biochem Physiol C Toxicol Pharmacol. 2018;210:30-34 pubmed publisher
    ..by reduced mRNA levels of seabream gonadotropin-releasing hormone (sbgnrh), g-protein-coupled receptor 54 (gpr54) in the kisspeptin/gpr54 system, as well as the gamma-aminobutyric acid (GABA) synthesis enzyme glutamic acid ..
  16. Renukanthan A, Quinton R, Turner B, MacCallum P, Seal L, Davies A, et al. Kallmann syndrome patient with gender dysphoria, multiple sclerosis, and thrombophilia. Endocrine. 2015;50:496-503 pubmed publisher
    ..remains unknown: his screening tests were negative for mutations in CHD7, FGF8, FGFR1, GNRH1, GNRHR, HS6ST1, KAL1, KISS1R, KISS1, NELF, PROK2, PROKR2, TAC3, and TACR3...
  17. Saedi S, Khoradmehr A, Mohammad Reza J, Tamadon A. The role of neuropeptides and neurotransmitters on kisspeptin/kiss1r-signaling in female reproduction. J Chem Neuroanat. 2018;92:71-82 pubmed publisher
  18. Navarro V. Interactions between kisspeptins and neurokinin B. Adv Exp Med Biol. 2013;784:325-47 pubmed publisher
    ..have revealed that loss-of-function mutations in the genes encoding either kisspeptin and NKB or their receptors, Kiss1r and neurokinin 3 receptor (NK3R), lead to impaired sexual maturation and infertility...
  19. Ciechanowska M, Kowalczyk M, Lapot M, Malewski T, Antkowiak B, Brytan M, et al. Effect of corticotropin releasing hormone and corticotropin releasing hormone nist on biosynthesis of gonadotropin relasing hormone and gonadotropin relasing hormone receptor in the hypothalamic-pituitary unit of follicular-phase ewes and contributio. J Physiol Pharmacol. 2018;69: pubmed publisher
    ..the levels of kisspeptin (Kiss1) mRNA in POA and VMH including arcuate nucleus (VMH/ARC), and on Kiss1 receptor (Kiss1r) mRNA abundance in POA-hypothalamic structures...
  20. Jin S, Sun D, Xi Q, Dong X, Song D, Fu H, et al. Identification of genes in the hypothalamus-pituitary-gonad axis in the brain of Amur sturgeons (Acipenser schrenckii) by comparative transcriptome analysis in relation to kisspeptin treatment. Gene. 2016;595:53-61 pubmed publisher
    ..These results support important roles for KISS1 in the regulation of the HPG axis, and in sex differentiation and reproduction in the Amur sturgeon. ..
  21. Roselli C, Amodei R, Gribbin K, Corder K, Stormshak F, Estill C. Excess Testosterone Exposure Alters Hypothalamic-Pituitary-Testicular Axis Dynamics and Gene Expression in Sheep Fetuses. Endocrinology. 2016;157:4234-4245 pubmed
    ..additional differences in the gene expression of GnRH, estrogen receptor-?, and kisspeptin receptor (G protein coupled receptor 54) emerged between the treatment cohorts...
  22. Jing X, Peng Q, Hu R, Wang H, Yu X, Degen A, et al. Effect of supplements during the cold season on the reproductive system in prepubertal Tibetan sheep ewes. Anim Sci J. 2017;88:1269-1278 pubmed publisher
    ..05). The messenger RNA (mRNA) expression of KiSS-1, GPR54 (G protein-coupled receptor 54), ER? (estradiol receptor ?) in the hypothalamic anteroventral periventricular area ..
  23. Yap C, Wharfe M, Mark P, Waddell B, Smith J. Diurnal regulation of hypothalamic kisspeptin is disrupted during mouse pregnancy. J Endocrinol. 2016;229:307-18 pubmed publisher
    ..We aimed to characterize hypothalamic Kiss1 and Kiss1r mRNA expression in nonpregnant and pregnant mice, and investigate potential circadian regulation...
  24. Sukhbaatar U, Mijiddorj T, Oride A, Kanasaki H. Stimulation of δ subunit-containing GABAA receptor by DS1 increases GnRH receptor expression but reduces GnRH mRNA expression in GnRH-producing GT1-7 cells. Endocrine. 2015;49:222-30 pubmed publisher
    ..In G protein-coupled receptor 54 (GPR54)-overexpressing GT1-7 cells, both DS1 and kisspeptin-10 stimulated SRE promoter activity, and combined treatment ..
  25. Han X, Zhou Y, Zeng Y, Sui F, Liu Y, Tan Y, et al. Effects of active immunization against GnRH versus surgical castration on hypothalamic-pituitary function in boars. Theriogenology. 2017;97:89-97 pubmed publisher
    ..05) mRNA expressions of GnRH, GnRH up-stream gatekeeper genes kiss1 and its receptor (GPR54), and androgen receptor in the hypothalamic arcuate nucleus (ARC) and anteroventral periventricular nucleus (AVPV),..
  26. Leka Emiri S, Chrousos G, Kanaka Gantenbein C. The mystery of puberty initiation: genetics and epigenetics of idiopathic central precocious puberty (ICPP). J Endocrinol Invest. 2017;40:789-802 pubmed publisher
    ..or autosomal forms of Kallmann syndrome and in precocious puberty have been identified (GNRH1, GNRHR, KISS1, GPR54, FGFR1, FGF8, PROK2, PROKR2, TAC3, TACR3, KAL1, PROK2, PROKR2, CHD7, LEP, LEPR, PC1, DAX1, SF-1, HESX-1, LHX3, ..
  27. Gahete M, Vázquez Borrego M, Martinez Fuentes A, Tena Sempere M, Castaño J, Luque R. Role of the Kiss1/Kiss1r system in the regulation of pituitary cell function. Mol Cell Endocrinol. 2016;438:100-106 pubmed publisher
    ..regulates reproductive events, including puberty and ovulation, primarily by activating the surface receptor Kiss1r (aka GPR54), at hypothalamic gonadotropin-releasing hormone (GnRH) neurons...
  28. Jiang J, He Z, Peng Y, Jin W, Wang Z, Han R, et al. Kisspeptin-13 enhances memory and mitigates memory impairment induced by Aβ1-42 in mice novel object and object location recognition tasks. Neurobiol Learn Mem. 2015;123:187-95 pubmed publisher
    Kisspeptin (KP), the endogenous ligand of GPR54, is a recently discovered neuropeptide shown to be involved in regulating reproductive system, anxiety-related behavior, locomotion, food intake, and suppression of metastasis across a ..
  29. Uenoyama Y, Pheng V, Tsukamura H, Maeda K. The roles of kisspeptin revisited: inside and outside the hypothalamus. J Reprod Dev. 2016;62:537-545 pubmed publisher
    ..in the direct activation of gonadotropin-releasing hormone (GnRH) neurons after binding to its cognate receptor, GPR54. Ever since the discovery of kisspeptin, intensive studies on hypothalamic expression of KISS1/Kiss1 and on ..
  30. Higo S, Iijima N, Ozawa H. Characterisation of Kiss1r (Gpr54)-Expressing Neurones in the Arcuate Nucleus of the Female Rat Hypothalamus. J Neuroendocrinol. 2017;29: pubmed publisher
    ..Our recent research using in situ hybridisation (ISH) clarified the histological distribution of Kiss1r (Gpr54)-expressing neurones in the rat brain that were presumed to be putative targets of kisspeptin...
  31. Evans B, Wang Z, Mobley L, Khosravi D, Fujii N, Navenot J, et al. Physical association of GPR54 C-terminal with protein phosphatase 2A. Biochem Biophys Res Commun. 2008;377:1067-71 pubmed publisher
    ..gene and subsequently found to encode kisspeptins (KP), ligands for a G protein coupled receptor (GPCR), GPR54. This ligand-receptor pair was later shown to play a critical role in the neuro-endocrine regulation of puberty...
  32. Li X, Kinsey Jones J, Cheng Y, Knox A, Lin Y, Petrou N, et al. Kisspeptin signalling in the hypothalamic arcuate nucleus regulates GnRH pulse generator frequency in the rat. PLoS ONE. 2009;4:e8334 pubmed publisher
    ..known to be the site of the gonadotropin-releasing hormone (GnRH) pulse generator we explored whether kisspeptin-GPR54 signalling in the ARC regulates GnRH pulses...
  33. Shoji S, Nakano M, Tomonaga T, Kim H, Hanai K, Usui Y, et al. Value of metastin receptor immunohistochemistry in predicting metastasis after radical nephrectomy for pT1 clear cell renal cell carcinoma. Clin Exp Metastasis. 2013;30:607-14 pubmed publisher
    ..of human melanoma, and encodes metastin, which was identified as the ligand of a G-protein-coupled receptor (metastin receptor)...
  34. Yaron M, Renner U, Gilad S, Stalla G, Stern N, Greenman Y. KISS1 receptor is preferentially expressed in clinically non-functioning pituitary tumors. Pituitary. 2015;18:306-11 pubmed publisher
    KISS1 is a metastasis suppressor gene involved in cancer biology. Given the high expression levels of KISS1 and KISS1R in the hypothalamus and the pituitary respectively, we hypothesized that this system could possibly affect tumor ..
  35. Qiu W, Zhao Y, Yang M, Farajzadeh M, Pan C, Wayne N. Actions of Bisphenol A and Bisphenol S on the Reproductive Neuroendocrine System During Early Development in Zebrafish. Endocrinology. 2016;157:636-47 pubmed publisher
    ..GnRH3 neurons in both terminal nerve and hypothalamus, increased expression of reproduction-related genes (kiss1, kiss1r, gnrh3, lhβ, fshβ, and erα), and a marker for synaptic transmission (sv2)...
  36. Morelli A, Marini M, Mancina R, Luconi M, Vignozzi L, Fibbi B, et al. Sex steroids and leptin regulate the "first Kiss" (KiSS 1/G-protein-coupled receptor 54 system) in human gonadotropin-releasing-hormone-secreting neuroblasts. J Sex Med. 2008;5:1097-1113 pubmed publisher
    The G-protein-coupled receptor 54 (GPR54) and its ligand kisspeptin, encoded by the KiSS-1 gene, have been involved in the molecular mechanisms underlying the reawakening of gonadotropin-releasing hormone (GnRH) neurons at puberty...
  37. Trarbach E, Teles M, Costa E, Abreu A, Garmes H, Guerra G, et al. Screening of autosomal gene deletions in patients with hypogonadotropic hypogonadism using multiplex ligation-dependent probe amplification: detection of a hemizygosis for the fibroblast growth factor receptor 1. Clin Endocrinol (Oxf). 2010;72:371-6 pubmed publisher
    ..MLPA) assay to evaluate the potential contribution of heterozygous deletions of FGFR1, GnRH1, GnRHR, GPR54 and NELF genes in the aetiology of GnRH deficiency...
  38. Teles M, Silveira L, BIANCO S, Latronico A. Human diseases associated with GPR54 mutations. Prog Mol Biol Transl Sci. 2009;88:33-56 pubmed publisher
    G protein-coupled receptor 54 (GPR54) was first described as an orphan receptor in the rat brain one decade ago...
  39. Bianco S, Vandepas L, Correa Medina M, Gereben B, Mukherjee A, Kuohung W, et al. KISS1R intracellular trafficking and degradation: effect of the Arg386Pro disease-associated mutation. Endocrinology. 2011;152:1616-26 pubmed publisher
    The goal of this study was to investigate how the Arg386Pro mutation prolongs KiSS-1 receptor (KISS1R) responsiveness to kisspeptin, contributing to human central precocious puberty...
  40. Neocleous V, Shammas C, Phelan M, Nicolaou S, Phylactou L, Skordis N. In silico analysis of a novel MKRN3 missense mutation in familial central precocious puberty. Clin Endocrinol (Oxf). 2016;84:80-4 pubmed publisher
    ..secretion in central precocious puberty (CPP) may arise either from gain-of-function mutations of the KISS1 and KISS1R genes or from loss-of-function manner mutations of the MKRN3 gene leading to MKRN3 deficiency...
  41. Fairgrieve M, Shibata Y, Smith E, Hayman E, Luckenbach J. Molecular characterization of the gonadal kisspeptin system: Cloning, tissue distribution, gene expression analysis and localization in sablefish (Anoplopoma fimbria). Gen Comp Endocrinol. 2016;225:212-223 pubmed publisher
    ..of four kisspeptin system mRNAs (kisspeptin 1 (kiss1), kiss2, and G protein-coupled receptor 54-1 (gpr54-1) and gpr54-2) in sablefish, Anoplopoma fimbria...
  42. De Bond J, Tolson K, Nasamran C, Kauffman A, Smith J. Unaltered Hypothalamic Metabolic Gene Expression in Kiss1r Knockout Mice Despite Obesity and Reduced Energy Expenditure. J Neuroendocrinol. 2016;28: pubmed publisher
    Kisspeptin controls reproduction by stimulating gonadotrophin-releasing hormone neurones via its receptor Kiss1r. Kiss1r is also expressed other brain areas and in peripheral tissues, suggesting additional nonreproductive roles...
  43. Zhai J, Liu J, Zhao S, Zhao H, Chen Z, Du Y, et al. Kisspeptin-10 inhibits OHSS by suppressing VEGF secretion. Reproduction. 2017;154:355-362 pubmed publisher
    ..OHSS is a systemic disorder with high vascular permeability (VP) and ovarian enlargement. KISS1R (KISS1 receptor) is the specific receptor of kisspeptin...
  44. Zhu Z, Huang F, Wang F, Zhang Y, Zhao X, Wang W. Morinda Officinalis Polysaccharides Stimulate Hypothalamic GnRH Secretion in Varicocele Progression. Evid Based Complement Alternat Med. 2017;2017:9057959 pubmed publisher
    ..Moreover, MOP-mediated Kisspeptin-GPR54 pathway upregulation and MAPK phosphorylation activation may have been responsible for increases in GnRH synthesis ..
  45. Bo Abbas Y, Acierno J, Shagoury J, Crowley W, Seminara S. Autosomal recessive idiopathic hypogonadotropic hypogonadism: genetic analysis excludes mutations in the gonadotropin-releasing hormone (GnRH) and GnRH receptor genes. J Clin Endocrinol Metab. 2003;88:2730-7 pubmed
  46. Babwah A, Navarro V, Ahow M, Pampillo M, Nash C, Fayazi M, et al. GnRH Neuron-Specific Ablation of Gαq/11 Results in Only Partial Inactivation of the Neuroendocrine-Reproductive Axis in Both Male and Female Mice: In Vivo Evidence for Kiss1r-Coupled Gαq/11-Independent GnRH Secretion. J Neurosci. 2015;35:12903-16 pubmed publisher
    ..KP signals via KISS1R, a Gαq/11-coupled receptor, and mice bearing a global deletion of Kiss1r (Kiss1r(-/-)) or a GnRH neuron-..
  47. Escobar S, Felip A, Zanuy S, Carrillo M. Is the kisspeptin system involved in responses to food restriction in order to preserve reproduction in pubertal male sea bass (Dicentrarchus labrax)?. Comp Biochem Physiol A Mol Integr Physiol. 2016;199:38-46 pubmed publisher
    ..glimpse of these regulatory mechanisms, kiss1 and kiss2 mRNA expression levels and those of their kiss receptors (kiss1r, kiss2r) were analyzed in different areas of the brain and in the pituitary of pubertal male sea bass during ..
  48. Garcia J, Guerriero K, Keen K, Kenealy B, Seminara S, Terasawa E. Kisspeptin and Neurokinin B Signaling Network Underlies the Pubertal Increase in GnRH Release in Female Rhesus Monkeys. Endocrinology. 2017;158:3269-3280 pubmed publisher
    Loss-of-function or inactivating mutations in the genes coding for kisspeptin and its receptor (KISS1R) or neurokinin B (NKB) and the NKB receptor (NK3R) in humans result in a delay in or the absence of puberty...
  49. Alavi M, Shamsizadeh A, Azhdari Zarmehri H, Roohbakhsh A. Orphan G protein-coupled receptors: The role in CNS disorders. Biomed Pharmacother. 2018;98:222-232 pubmed publisher
    ..GPR3, GPR6, GPR17, GPR26, GPR37, GPR39, GPR40, GPR50, GPR52, GPR54, GPR55, GPR85, GPR88, GPR103, and GPR139 are the selected orphan GPCRs for this article...
  50. Zmora N, Stubblefield J, Wong T, Levavi Sivan B, Millar R, Zohar Y. Kisspeptin Antagonists Reveal Kisspeptin 1 and Kisspeptin 2 Differential Regulation of Reproduction in the Teleost, Morone saxatilis. Biol Reprod. 2015;93:76 pubmed publisher
    ..Pep 234 (a mammalian KISS1 antagonist) antagonizes Kiss1r signaling activated by Kiss1 and Kiss2, and pep 359 (a novel analog) antagonizes Kiss2 activation of both ..
  51. Zhu C, Takasu C, Morine Y, Bando Y, Ikemoto T, Saito Y, et al. KISS1 Associates with Better Outcome via Inhibiting Matrix Metalloproteinase-9 in Colorectal Liver Metastasis. Ann Surg Oncol. 2015;22 Suppl 3:S1516-23 pubmed publisher
    ..KISS1, originally identified to be a metastasis suppressor, couples to its receptor KISS1R and plays a pivotal role in suppressing cancer metastasis...
  52. Chianese R, Cobellis G, Chioccarelli T, Ciaramella V, Migliaccio M, Fasano S, et al. Kisspeptins, Estrogens and Male Fertility. Curr Med Chem. 2016;23:4070-4091 pubmed
    ..Kisspeptins, via the activation of kisspeptin receptor Gpr54 represent the main gatekeeper of the hypothalamic Gonadotropin Releasing Hormone (GnRH) centrally modulating the ..
  53. Sarchielli E, Comeglio P, Squecco R, Ballerini L, Mello T, Guarnieri G, et al. Tumor Necrosis Factor-α Impairs Kisspeptin Signaling in Human Gonadotropin-Releasing Hormone Primary Neurons. J Clin Endocrinol Metab. 2017;102:46-56 pubmed publisher
    ..primary hfHypo showed a high percentage of GnRH-positive cells (80%), expressing a functional kisspeptin receptor (KISS1R) and able to release GnRH in response to kisspeptin...
  54. Nikitina I, Khoduleva Y, Masel A, Bairamov A, Shabanov P. System of KISS-KISS1R: focus on peripheral signaling in androgen-dependent tissues in the experimentally induced model hypogonadotropic hypogonadism. Patol Fiziol Eksp Ter. 2016;60:24-33 pubmed
    Kisspeptins, ligands of G protein-coupled receptor 54 (GPR54) encoded by the KiSS-1 gene, have recently emerged as key gatekeepers of the gonadotropic axis...
  55. Fayazi M, Calder M, Bhattacharya M, Vilos G, Power S, Babwah A. The pregnant mouse uterus exhibits a functional kisspeptin/KISS1R signaling system on the day of embryo implantation. Reprod Biol Endocrinol. 2015;13:105 pubmed publisher
    Expression of kisspeptin (protein) and Kiss1r (mRNA) was recently documented in the mouse uterus on D4 of pregnancy (the day of embryo implantation) suggesting that the uterine-based kisspeptin (KP)/kisspeptin receptor (KISS1R) signaling ..
  56. León S, Barroso A, Vázquez M, García Galiano D, Manfredi Lozano M, Ruiz Pino F, et al. Direct Actions of Kisspeptins on GnRH Neurons Permit Attainment of Fertility but are Insufficient to Fully Preserve Gonadotropic Axis Activity. Sci Rep. 2016;6:19206 pubmed publisher
    Kisspeptins, ligands of the receptor, Gpr54, are potent stimulators of puberty and fertility. Yet, whether direct kisspeptin actions on GnRH neurons are sufficient for the whole repertoire of their reproductive effects remains debatable...
  57. Leon S, Fernandois D, Sull A, Sull J, Calder M, Hayashi K, et al. Beyond the brain-Peripheral kisspeptin signaling is essential for promoting endometrial gland development and function. Sci Rep. 2016;6:29073 pubmed publisher
    ..Kisspeptin, which signals via Kiss1r, is essential for fertility, primarily through its central control of the hypothalamic-pituitary-ovarian axis, but ..
  58. Yang J, Yasrebi A, Snyder M, Roepke T. The interaction of fasting, caloric restriction, and diet-induced obesity with 17?-estradiol on the expression of KNDy neuropeptides and their receptors in the female mouse. Mol Cell Endocrinol. 2016;437:35-50 pubmed publisher
    ..Diet-induced obesity decreased Kiss1 in oil-treated animals and the kisspeptin receptor, Kiss1r and Tac3r in the ARC of E2B-treated animals...
  59. Rather M, Basha S, Bhat I, Sharma N, Nandanpawar P, Badhe M, et al. Characterization, molecular docking, dynamics simulation and metadynamics of kisspeptin receptor with kisspeptin. Int J Biol Macromol. 2017;101:241-253 pubmed publisher
    We report molecular characterization of the kisspeptin receptor (kiss1r), an essential gatekeeper for reproduction and onset of puberty in vertebrates...
  60. Abreu A, Trarbach E, de Castro M, Frade Costa E, Versiani B, Matias Baptista M, et al. Loss-of-function mutations in the genes encoding prokineticin-2 or prokineticin receptor-2 cause autosomal recessive Kallmann syndrome. J Clin Endocrinol Metab. 2008;93:4113-8 pubmed publisher
    ..Physiological activation of the prokineticin pathway has a critical role in olfactory bulb morphogenesis and GnRH secretion in mice...
  61. Cartwright J, Williams P. Altered placental expression of kisspeptin and its receptor in pre-eclampsia. J Endocrinol. 2012;214:79-85 pubmed publisher
    ..current study therefore sets out to characterise placental expression of both kisspeptin (KISS1) and its receptor (KISS1R) throughout pregnancy and in PE...
  62. Chianese R, Ciaramella V, Fasano S, Pierantoni R, Meccariello R. Kisspeptin regulates steroidogenesis and spermiation in anuran amphibian. Reproduction. 2017;154:403-414 pubmed publisher
    ..model, we demonstrate - for the first time in non-mammalian vertebrate - that testis expresses both Kiss-1 and Gpr54 proteins during the annual sexual cycle and that ex vivo 17B-estradiol (E2, 10-6?M) ..
  63. Nakajo M, Kanda S, Karigo T, Takahashi A, Akazome Y, Uenoyama Y, et al. Evolutionally Conserved Function of Kisspeptin Neuronal System Is Nonreproductive Regulation as Revealed by Nonmammalian Study. Endocrinology. 2018;159:163-183 pubmed publisher
    The kisspeptin neuronal system, which consists of a neuropeptide kisspeptin and its receptor Gpr54, is considered in mammals a key factor of reproductive regulation, the so-called hypothalamic-pituitary-gonadal (HPG) axis...
  64. Hatef A, Unniappan S. Gonadotropin-releasing hormone, kisspeptin, and gonadal steroids directly modulate nucleobindin-2/nesfatin-1 in murine hypothalamic gonadotropin-releasing hormone neurons and gonadotropes. Biol Reprod. 2017;96:635-651 pubmed publisher
    ..Synthetic nesfatin-1 increased Kiss1r and Gnrh expression in GT1-7 cells and Lh? in L?T2...
  65. Kaiser U, Kuohung W. KiSS-1 and GPR54 as new players in gonadotropin regulation and puberty. Endocrine. 2005;26:277-84 pubmed
    The recent identification of loss-of-function mutations in the gene encoding GPR54, the receptor for the KiSS-1-derived peptides, kisspeptins, has highlighted a previously unrecognized pathway in the physiologic regulation of puberty and ..
  66. Pedersen White J, Chorich L, Bick D, Sherins R, Layman L. The prevalence of intragenic deletions in patients with idiopathic hypogonadotropic hypogonadism and Kallmann syndrome. Mol Hum Reprod. 2008;14:367-70 pubmed publisher
    ..patients were studied for KAL1 deletions and 100 were studied for an autosomal panel of FGFR1, GNRH1, GNRHR, GPR54 and NELF gene deletions. Of all male and female subjects screened, 4/54 (7.4%) had KAL1 deletions...
  67. Liu Y, Bai J, Xu X, Chen Z, Spicer L, Feng T. Effects of N-carbamylglutamate and l-arginine on gonadotrophin-releasing hormone (GnRH) gene expression and secretion in GT1-7 cells. Reprod Fertil Dev. 2017;: pubmed publisher
    ..GT1-7 cells express GnRH, Kiss-1 metastasis-suppressor (Kiss1), G-protein coupled receptor 54 (GPR54), neuronal nitric oxide synthase (nNOS) and estrogen receptor ? (ER?) genes. High concentrations of NCG (1...
  68. Marot D, Bieche I, Aumas C, Esselin S, Bouquet C, Vacher S, et al. High tumoral levels of Kiss1 and G-protein-coupled receptor 54 expression are correlated with poor prognosis of estrogen receptor-positive breast tumors. Endocr Relat Cancer. 2007;14:691-702 pubmed
    ..a marker of breast cancer, raising the question of whether expression of KiSS1 and its G-protein-coupled receptor (GPR54) is down- or upregulated by estrogens in breast cancer cells...
  69. Kanda S, Oka Y. Structure, synthesis, and phylogeny of kisspeptin and its receptor. Adv Exp Med Biol. 2013;784:9-26 pubmed publisher
    ..Furthermore, in nonmammalian species, there are two subtypes of receptors, Gpr54-1 (known as GPR54 or Kiss1R in mammals) and Gpr54-2...
  70. Luan X, Yu H, Wei X, Zhou Y, Wang W, Li P, et al. GPR54 polymorphisms in Chinese girls with central precocious puberty. Neuroendocrinology. 2007;86:77-83 pubmed
    The GPR54 gene has been proved to be important in the process of puberty onset, yet no association study has been performed to evaluate the effect of polymorphisms in the gene on central precocious puberty (CPP)...
  71. Makri A, Pissimissis N, Lembessis P, Polychronakos C, Koutsilieris M. The kisspeptin (KiSS-1)/GPR54 system in cancer biology. Cancer Treat Rev. 2008;34:682-92 pubmed publisher
    ..peptides (kp-54, kp-14, kp-13, kp-10), which are endogenous ligands to a G protein-coupled receptor, referred as hOT7T175 or AXOR12 or GPR54...
  72. Papaoiconomou E, Lymperi M, Petraki C, Philippou A, Msaouel P, Michalopoulou F, et al. Kiss-1/GPR54 protein expression in breast cancer. Anticancer Res. 2014;34:1401-7 pubmed
    ..Herein, we investigated the protein expression of Kiss-1 and its receptor GPR54 in breast cancer tissues compared to non-cancerous mammary tissues.
  73. Baba T, Kang H, Hosoe Y, Kharma B, Abiko K, Matsumura N, et al. Menstrual cyclic change of metastin/GPR54 in endometrium. Med Mol Morphol. 2015;48:76-84 pubmed publisher
    Metastin/kisspeptin is encoded by KISS1 and functions as an endogenous ligand of GPR54. Interaction of metastin with GPR54 suppresses metastasis and also regulates release of gonadotropin-releasing hormone, which promotes secretion of ..
  74. Rouméas L, Humbert J, Schneider S, Doebelin C, Bertin I, Schmitt M, et al. Effects of systematic N-terminus deletions and benzoylations of endogenous RF-amide peptides on NPFF1R, NPFF2R, GPR10, GPR54 and GPR103. Peptides. 2015;71:156-61 pubmed publisher
    ..Kisspeptins and RFa peptides are currently considered endogenous peptides for the GPCRs NPFF1R, NPFF2R, GPR10, GPR54 and GPR103, respectively...
  75. Makri A, Msaouel P, Petraki C, Milingos D, Protopapas A, Liapi A, et al. KISS1/KISS1R expression in eutopic and ectopic endometrium of women suffering from endometriosis. In Vivo. 2012;26:119-27 pubmed
    The KISS1/KISS1R system has been implicated in the physiology of reproduction and many studies have documented the stimulatory effect of kisspeptin on Gonadotropin-releasing Hormone (GnRH) and gonadotropin secretion...
  76. Guimiot F, Chevrier L, Dreux S, Chevenne D, Caraty A, Delezoide A, et al. Negative fetal FSH/LH regulation in late pregnancy is associated with declined kisspeptin/KISS1R expression in the tuberal hypothalamus. J Clin Endocrinol Metab. 2012;97:E2221-9 pubmed publisher
    ..neuropeptides that control GnRH release at pubertal onset and in adults via the activation of KISS-1 receptor (KISS1R)...
  77. Sato K, Shirai R, Hontani M, Shinooka R, Hasegawa A, Kichise T, et al. Potent Vasoconstrictor Kisspeptin-10 Induces Atherosclerotic Plaque Progression and Instability: Reversal by its Receptor GPR54 Antagonist. J Am Heart Assoc. 2017;6: pubmed publisher
    Kisspeptin-10 (KP-10), a potent vasoconstrictor and inhibitor of angiogenesis, and its receptor, GPR54, have currently received much attention in relation to pre-eclampsia...
  78. Rothenbuhler A, Lotton C, Fradin D. Three common variants of LEP, NPY1R and GPR54 show no association with age at menarche. Horm Res. 2009;71:331-5 pubmed publisher
    ..suspected to have a prominent role in reproductive physiology: leptin (LEP), neuropeptide Y receptor 1 (NPY1R) and GPR54. We selected the -2459 LEP, the rs7687423 NPY1R and thers350132 GPR54 variants as the more common coding or ..
  79. Yue Z, Yu M, Zhao H, Wang J, Zhang X, Tian H, et al. The anti-estrogenicity of chronic exposure to semicarbazide in female Japanese flounders (Paralichthys olivaceus), and its potential mechanisms. Mar Pollut Bull. 2018;129:806-812 pubmed publisher
    ..Furthermore, the kisspeptin/g protein-coupled receptor 54 (kiss/gpr54) system and gamma-aminobutyric acid-ergic (GABAergic) system were also affected by SMC: SMC significantly down-..
  80. Ji K, Ye L, Mason M, Jiang W. The Kiss-1/Kiss-1R complex as a negative regulator of cell motility and cancer metastasis (Review). Int J Mol Med. 2013;32:747-54 pubmed publisher
    ..are endogenous ligands of the Kiss?1 receptor (Kiss-1R), a G protein-coupled receptor (GPR) also known as hOT7T175, AXOR12 or GPR54...
  81. Francou B, Paul C, Amazit L, Cartes A, Bouvattier C, Albarel F, et al. Prevalence of KISS1 Receptor mutations in a series of 603 patients with normosmic congenital hypogonadotrophic hypogonadism and characterization of novel mutations: a single-centre study. Hum Reprod. 2016;31:1363-74 pubmed publisher
    What is the exact prevalence of Kisspeptin Receptor (KISS1R) mutations in the population of patients with normosmic congenital hypogonadotrophic hypogonadism (nCHH) by comparison with other genes, involved in gonadotrophin-releasing ..
  82. Bianco S, Kaiser U. Molecular biology of the kisspeptin receptor: signaling, function, and mutations. Adv Exp Med Biol. 2013;784:133-58 pubmed publisher
    Kisspeptin receptor (KISS1R) signaling is essential for the hallmark increase in pulsatile GnRH secretion characteristic of the onset of puberty in humans and experimental animals...
  83. Chevrier L, de Brevern A, Hernandez E, Leprince J, Vaudry H, Guedj A, et al. PRR repeats in the intracellular domain of KISS1R are important for its export to cell membrane. Mol Endocrinol. 2013;27:1004-14 pubmed publisher
    Inactivating mutations of KISS-1 receptor (KISS1R) have been recently described as a rare cause of isolated hypogonadotropic hypogonadism transmitted as a recessive trait...
  84. Brioude F, Bouligand J, Francou B, Fagart J, Roussel R, Viengchareun S, et al. Two families with normosmic congenital hypogonadotropic hypogonadism and biallelic mutations in KISS1R (KISS1 receptor): clinical evaluation and molecular characterization of a novel mutation. PLoS ONE. 2013;8:e53896 pubmed publisher
    b>KISS1R mutations have been reported in few patients with normosmic congenital hypogonadotropic hypogonadism (nCHH) (OMIM #146110)...
  85. Tesema B, Zhao J, Jiang X, Liu G, Han Y, Wassie T. Kisspeptin recombinant oral vaccine: A master gene vaccine inhibiting the reproductive physiology and behavior of ram lambs. Vaccine. 2017;: pubmed publisher
    ..stimulates gonadotrophic steroid hormone (GNRH) neuronal signaling through the G-protein coupled receptor, kiss1r. Disturbance of this signaling pathway causes hypogonadotropic hypogonadism in mammals...
  86. Wu S, Zhang H, Tian J, Liu L, Dong Y, Mao T. Expression of kisspeptin/GPR54 and PIBF/PR in the first trimester trophoblast and decidua of women with recurrent spontaneous abortion. Pathol Res Pract. 2014;210:47-54 pubmed publisher
    Kisspeptin and its receptor GPR54 play a major role in trophoblast invasion, and progesterone-induced blocking factor (PIBF) is needed for maintaining pregnancy...
  87. Roufidou C, Schmitz M, Mayer I, Sebire M, Katsiadaki I, Shao Y, et al. Hormonal changes over the spawning cycle in the female three-spined stickleback, Gasterosteus aculeatus. Gen Comp Endocrinol. 2018;257:97-105 pubmed publisher
    ..gonadotropin-releasing hormones (GnRHs: gnrh2, gnrh3) and kisspeptin (kiss2) and its G protein-coupled receptor (gpr54) in the brain were measured by real-time qPCR...
  88. Beltramo M, Decourt C. Towards new strategies to manage livestock reproduction using kisspeptin analogs. Theriogenology. 2018;112:2-10 pubmed publisher
    The discovery of the hypothalamic neuropeptide kisspeptin and its receptor (KISS1R) have dramatically improved our knowledge about the central mechanisms controlling reproduction...
  89. Sills E, Walsh A. The GPR54-Kisspeptin complex in reproductive biology: neuroendocrine significance and implications for ovulation induction and contraception. Neuro Endocrinol Lett. 2008;29:846-51 pubmed
    ..amide peptides, KP-54, was subsequently identified as the natural ligand for the G-protein coupled receptor-54 (GPR54)...
  90. Hata K, Watanabe Y, Nakai H, Minami T, Ohsaki H, Hirakawa E, et al. Association of metastin/a G-protein-coupled receptor signaling and Down syndrome critical region 1 in epithelial ovarian cancer. Anticancer Res. 2009;29:617-23 pubmed
    It has been revealed that metastin/a G-protein-coupled receptor (AXOR12) signaling enhances the expression of Down syndrome critical region 1 (DSCR1), known to be duplicated in Down syndrome, and suppresses tumor metastasis in in vitro ..
  91. Cvetkovic D, Dragan M, Leith S, Mir Z, Leong H, Pampillo M, et al. KISS1R induces invasiveness of estrogen receptor-negative human mammary epithelial and breast cancer cells. Endocrinology. 2013;154:1999-2014 pubmed publisher
    ..peptide products of the KISS1 metastasis-suppressor gene, are endogenous ligands for a G protein-coupled receptor (KISS1R). KISS1 acts as a metastasis suppressor in numerous human cancers...
  92. Pankov Y. [Kisspeptin and leptin in the regulation of fertility]. Mol Biol (Mosk). 2015;49:707-15 pubmed publisher
    Kisspeptin (KISS1) and its receptor (KISS1R) are important regulators of the reproductive function, along with gonadoliberin (GnRH), gonadotropins (luteinizing hormone (LH) and follicle-stimulating hormone (FSH)), and sex steroid hormones...