Gene Symbol: Kim-1
Description: hepatitis A virus cellular receptor 1
Alias: CD365, HAVCR, HAVCR-1, KIM-1, KIM1, TIM, TIM-1, TIM1, TIMD-1, TIMD1, hepatitis A virus cellular receptor 1, T cell immunoglobin domain and mucin domain protein 1, T-cell immunoglobulin mucin family member 1, T-cell immunoglobulin mucin receptor 1, T-cell membrane protein 1, kidney injury molecule 1
Species: human
Products:     Kim-1

Top Publications

  1. Kuehn E, Hirt M, John A, Muehlenhardt P, Boehlke C, Pütz M, et al. Kidney injury molecule 1 (Kim1) is a novel ciliary molecule and interactor of polycystin 2. Biochem Biophys Res Commun. 2007;364:861-6 pubmed publisher
    ..We have previously shown that overexpression of mutated forms of the chemosensor kidney injury molecule 1 (Kim1) abolishes the flow response in ciliated MDCK cells...
  2. Thompson P, Lu J, Kaplan G. The Cys-rich region of hepatitis A virus cellular receptor 1 is required for binding of hepatitis A virus and protective monoclonal antibody 190/4. J Virol. 1998;72:3751-61 pubmed
    The hepatitis A virus cellular receptor 1 (HAVcr-1) cDNA codes for a class I integral membrane glycoprotein, termed havcr-1, of unknown natural function which serves as an African green monkey kidney (AGMK) cell receptor for HAV...
  3. Nogare A, Dalpiaz T, Veronese F, Goncalves L, Manfro R. Noninvasive analyses of kidney injury molecule-1 messenger RNA in kidney transplant recipients with graft dysfunction. Transplant Proc. 2012;44:2297-9 pubmed publisher
    ..A significant correlation between gene expression in samples of urine and tissue cells was found (P < .01). These initial data suggests that KIM-1 gene mRNA quantification can be used as a noninvasive biomarker of IF/TA. ..
  4. Feigelstock D, Thompson P, Mattoo P, Zhang Y, Kaplan G. The human homolog of HAVcr-1 codes for a hepatitis A virus cellular receptor. J Virol. 1998;72:6621-8 pubmed
    The hepatitis A virus cellular receptor 1 (HAVcr-1) cDNA was isolated from a cDNA expression library of African green monkey kidney (AGMK) cells by using protective monoclonal antibody (MAb) 190/4, which blocks the binding of hepatitis A ..
  5. Xu P, Zhang J, Chen M, LV J, Liu G, Zou W, et al. Urinary kidney injury molecule-1 in patients with IgA nephropathy is closely associated with disease severity. Nephrol Dial Transplant. 2011;26:3229-36 pubmed publisher
    ..553, P = 0.032). Renal survival was significantly worse in patients with elevated urinary KIM-1 (P = 0.020). Urinary KIM-1 may be a useful biomarker to evaluate kidney injury in IgAN. ..
  6. Kondratowicz A, Lennemann N, Sinn P, Davey R, Hunt C, Moller Tank S, et al. T-cell immunoglobulin and mucin domain 1 (TIM-1) is a receptor for Zaire Ebolavirus and Lake Victoria Marburgvirus. Proc Natl Acad Sci U S A. 2011;108:8426-31 pubmed publisher
    ..Here, we show that T-cell Ig and mucin domain 1 (TIM-1) binds to the receptor binding domain of the Zaire Ebola virus (EBOV) glycoprotein, and ectopic TIM-1 expression ..
  7. de Souza A, Oak J, Jordanhazy R, DeKruyff R, Fruman D, Kane L. T cell Ig and mucin domain-1-mediated T cell activation requires recruitment and activation of phosphoinositide 3-kinase. J Immunol. 2008;180:6518-26 pubmed
    Ligation of the transmembrane protein T cell Ig and mucin domain (Tim)-1 can costimulate T cell activation. Agonistic Abs to Tim-1 are also capable of inducing T cell activation without additional stimuli...
  8. Nepal M, Bock G, Sehic A, Schultz M, Zhang P. Kidney injury molecule-1 expression identifies proximal tubular injury in urate nephropathy. Ann Clin Lab Sci. 2008;38:210-4 pubmed
    ..In their renal biopsies, we demonstrate upregulation of kidney injury molecule-1 (KIM-1), a specific injury marker, in proximal tubular cells. This finding implicates a role for proximal tubular injury in urate nephropathy. ..
  9. Kwon S, Park M, Jeon J, Noh H, Choi S, Kim J, et al. KIM-1 expression predicts renal outcomes in IgA nephropathy. Clin Exp Nephrol. 2013;17:359-64 pubmed publisher
    ..The concentration of urinary KIM-1/Cr in patients with IgAN was significantly higher than that in the normal controls. Tissue KIM-1 expression is an independent predictor of adverse renal outcomes in IgA nephropathy patients. ..

More Information

Publications119 found, 100 shown here

  1. Kobayashi N, Karisola P, Pena Cruz V, Dorfman D, Jinushi M, Umetsu S, et al. TIM-1 and TIM-4 glycoproteins bind phosphatidylserine and mediate uptake of apoptotic cells. Immunity. 2007;27:927-40 pubmed
    The T cell immunoglobulin mucin (TIM) proteins regulate T cell activation and tolerance...
  2. Vaidya V, Ford G, Waikar S, Wang Y, Clement M, Ramirez V, et al. A rapid urine test for early detection of kidney injury. Kidney Int. 2009;76:108-14 pubmed publisher
  3. Liangos O, Tighiouart H, Perianayagam M, Kolyada A, Han W, Wald R, et al. Comparative analysis of urinary biomarkers for early detection of acute kidney injury following cardiopulmonary bypass. Biomarkers. 2009;14:423-31 pubmed publisher
    ..006). In this small pilot cohort, KIM-1 performed best as an early biomarker for AKI. Larger studies are needed to explore further the role of biomarkers for early detection of AKI following cardiac surgery. ..
  4. Peters H, Waanders F, Meijer E, van den Brand J, Steenbergen E, van Goor H, et al. High urinary excretion of kidney injury molecule-1 is an independent predictor of end-stage renal disease in patients with IgA nephropathy. Nephrol Dial Transplant. 2011;26:3581-8 pubmed publisher
    ..KIM-1 and NGAL excretion are increased in patients with IgAN and correlate with proteinuria but not with eGFR. Baseline serum creatinine and urinary KIM-1, but not proteinuria, are independent predictors of ESRD. ..
  5. Shao X, Tian L, Xu W, Zhang Z, Wang C, Qi C, et al. Diagnostic value of urinary kidney injury molecule 1 for acute kidney injury: a meta-analysis. PLoS ONE. 2014;9:e84131 pubmed publisher
    Urinary Kidney Injury Molecule 1 (KIM-1) is a proximal tubular injury biomarker for early detection of acute kidney injury (AKI), with variable performance characteristics depending on clinical and population settings...
  6. McIntire J, Umetsu D, DeKruyff R. TIM-1, a novel allergy and asthma susceptibility gene. Springer Semin Immunopathol. 2004;25:335-48 pubmed
    ..asthma, we simplified this complex trait and identified the novel T cell immunoglobulin domain, mucin-like domain (TIM) gene family, that encodes transmembrane proteins expressed by CD4 T cells...
  7. Parikh C, Thiessen Philbrook H, Garg A, Kadiyala D, Shlipak M, Koyner J, et al. Performance of kidney injury molecule-1 and liver fatty acid-binding protein and combined biomarkers of AKI after cardiac surgery. Clin J Am Soc Nephrol. 2013;8:1079-88 pubmed publisher
    ..Postoperative elevations of KIM-1 associate with AKI and adverse outcmes in adults but were not independent of other AKI biomarkers. A panel of multiple biomarkers provided moderate discrimination for AKI. ..
  8. Bailly V, Zhang Z, Meier W, Cate R, Sanicola M, Bonventre J. Shedding of kidney injury molecule-1, a putative adhesion protein involved in renal regeneration. J Biol Chem. 2002;277:39739-48 pubmed
  9. Liang X, Liu S, Chen Y, Yan L, Li H, Xuan H, et al. Combination of urinary kidney injury molecule-1 and interleukin-18 as early biomarker for the diagnosis and progressive assessment of acute kidney injury following cardiopulmonary bypass surgery: a prospective nested case-control study. Biomarkers. 2010;15:332-9 pubmed publisher
    ..The combination of these two biomarkers facilitates the early diagnosis and assessment of the likely progression of AKI after CPB. ..
  10. Kotsis F, Nitschke R, Boehlke C, Bashkurov M, Walz G, Kuehn E. Ciliary calcium signaling is modulated by kidney injury molecule-1 (Kim1). Pflugers Arch. 2007;453:819-29 pubmed
    ..We show that a novel interactor of TRPP2, kidney injury molecule-1 (Kim1), which is expressed at low levels in the normal kidney and upregulated after ischemia, in renal cell cancer and in ..
  11. Cen C, Aziz M, Yang W, Zhou M, Nicastro J, Coppa G, et al. Milk fat globule-epidermal growth factor-factor VIII attenuates sepsis-induced acute kidney injury. J Surg Res. 2017;213:281-289 pubmed publisher
    ..Thus, MFG-E8 may have a therapeutic potential for treating AKI induced by sepsis. ..
  12. Gooding J, Cao L, Whitaker C, Mwiza J, Fernander M, Ahmed F, et al. Meprin β metalloproteases associated with differential metabolite profiles in the plasma and urine of mice with type 1 diabetes and diabetic nephropathy. BMC Nephrol. 2019;20:141 pubmed publisher
    ..Taken together, the annotated metabolites suggest that meprin β impacts complications of diabetes such as DKD by altering distinct metabolite profiles. ..
  13. Naguib Y, Azmy R, Samaka R, Salem M. Pleurotus ostreatus opposes mitochondrial dysfunction and oxidative stress in acetaminophen-induced hepato-renal injury. BMC Complement Altern Med. 2014;14:494 pubmed publisher
    ..We report here that the antioxidant effect of Pleurotus ostreatus opposes mitochondrial dysfunction and oxidative stress accompanying APAP over-dose, with subsequent clinically beneficial effects on liver and kidney tissues. ..
  14. Trujillo J, Molina Jijón E, Medina Campos O, Rodríguez Muñoz R, Reyes J, Loredo M, et al. Curcumin prevents cisplatin-induced decrease in the tight and adherens junctions: relation to oxidative stress. Food Funct. 2016;7:279-93 pubmed publisher
  15. Mahgoub E, Kumaraswamy S, Kader K, Venkataraman B, Ojha S, Adeghate E, et al. Genipin attenuates cisplatin-induced nephrotoxicity by counteracting oxidative stress, inflammation, and apoptosis. Biomed Pharmacother. 2017;93:1083-1097 pubmed publisher
    ..Thus, our results suggest that the use of GP may be a promising new protective strategy against cisplatin-induced nephrotoxicity. ..
  16. Lock E, Keane P, Rowe P, Foster J, Antoine D, Morris C. Trichloroethylene-induced formic aciduria in the male C57 Bl/6 mouse. Toxicology. 2017;378:76-85 pubmed publisher
    ..Thus, TCE-induced formic aciduria may be a contributor factor in the chronic renal injury seen in male and female rats and mice. ..
  17. Kristensen B. Regulatory B and T cell responses in patients with autoimmune thyroid disease and healthy controls. Dan Med J. 2016;63: pubmed
    ..Several phenotypes have been associated with B10 cells such as CD5+, CD25+, TIM-1+, CD24hiCD38hi and CD27+CD43+...
  18. Wang Y, Han R, Song S, Yuan X, Ren X. Inhibition of PARP overactivation protects acute kidney injury of septic shock. Eur Rev Med Pharmacol Sci. 2018;22:6049-6056 pubmed publisher
    ..Inhibition of PARP overactivation alleviated pathological kidney lesions, improved kidney energy metabolism and inhibited inflammatory response resulted from AKI. ..
  19. Wildemann T, Siciliano S, Weber L. The mechanisms associated with the development of hypertension after exposure to lead, mercury species or their mixtures differs with the metal and the mixture ratio. Toxicology. 2016;339:1-8 pubmed publisher
  20. Manne N, Arvapalli R, Nepal N, Shokuhfar T, Rice K, Asano S, et al. Cerium oxide nanoparticles attenuate acute kidney injury induced by intra-abdominal infection in Sprague-Dawley rats. J Nanobiotechnology. 2015;13:75 pubmed publisher
    ..Taken together, the data indicate that CeO2 nanoparticles may be useful as an alternative therapeutic agent or in conjunction with standard medical care for the treatment of peritonitis induced acute kidney injury. ..
  21. Hamel R, Dejarnac O, Wichit S, Ekchariyawat P, Neyret A, Luplertlop N, et al. Biology of Zika Virus Infection in Human Skin Cells. J Virol. 2015;89:8880-96 pubmed publisher
    ..Several entry and/or adhesion factors, including DC-SIGN, AXL, Tyro3, and, to a lesser extent, TIM-1, permitted ZIKV entry, with a major role for the TAM receptor AXL...
  22. Teksen Y, Kadıoglu E, Koçak C, Koçak H. Effect of Hydrogen Sulfide on Kidney Injury in Rat Model of Crush Syndrome. J Surg Res. 2019;235:470-478 pubmed publisher
    ..NaHS decreased renal damage and apoptosis in crush-related acute kidney injury. These results suggest that H2S could reduce crush-related acute kidney injury via anti-inflammatory, antioxidant, and antiapoptotic effects. ..
  23. Kankuri E, Mervaala E, Storvik M, Ahola A, Levijoki J, Müller D, et al. Exacerbation of acute kidney injury by bone marrow stromal cells from rats with persistent renin-angiotensin system activation. Clin Sci (Lond). 2015;128:735-47 pubmed publisher
    ..Our results demonstrate that early persistent RAS activation can dramatically compromise therapeutic potential of BMSCs by causing a shift into a pro-inflammatory phenotype with mitochondrial dysfunction. ..
  24. Kong D, Hao L, Zhang L, Li Q, Zhou J, Shi S, et al. Comparison of two fluid solutions for resuscitation in a rabbit model of crush syndrome. Clin Exp Nephrol. 2015;19:1015-23 pubmed publisher
    ..There was no significant difference in the ability of preventing AKI after a crush injury between the two fluid solutions, while SAL/HES can improve the survival rate. ..
  25. Adil M, Kandhare A, Ghosh P, Venkata S, Raygude K, Bodhankar S. Ameliorative effect of naringin in acetaminophen-induced hepatic and renal toxicity in laboratory rats: role of FXR and KIM-1. Ren Fail. 2016;38:1007-20 pubmed publisher
    ..Naringin treatment also reduced histological alteration induced by APAP in the liver and kidney. Naringin exerts its hepato- and nephroprotective effect via modulation of oxido-nitrosative stress, FXR and KIM-1 mRNA expression. ..
  26. Sampaio T, Menezes R, da Costa M, Meneses G, Arrieta M, Chaves Filho A, et al. Nephroprotective effects of (-)-?-bisabolol against ischemic-reperfusion acute kidney injury. Phytomedicine. 2016;23:1843-1852 pubmed publisher
    ..Bisabolol has a nephroprotective effect in kidney I/R, with antioxidant effect. Moreover, this result seems to be associated to a direct protective effect on tubular epithelia. ..
  27. Schindler K, Bondeva T, Schindler C, Claus R, Franke S, Wolf G. Preconditioned suppression of prolyl-hydroxylases attenuates renal injury but increases mortality in septic murine models. Nephrol Dial Transplant. 2016;31:1100-13 pubmed publisher
  28. Mou Z, Shi J, Tan Y, Xu R, Zhao Z, Xu G, et al. Association between TIM-1 gene polymorphisms and allergic rhinitis in a Han Chinese population. J Investig Allergol Clin Immunol. 2010;20:3-8 pubmed
    b>TIM-1, a member of the T cell immunoglobulin and mucin (TIM) domain family, is involved in T-cell differentiation and has been implicated in allergic diseases...
  29. Moller Tank S, Albritton L, Rennert P, Maury W. Characterizing functional domains for TIM-mediated enveloped virus entry. J Virol. 2014;88:6702-13 pubmed publisher
    T-cell immunoglobulin and mucin domain 1 (TIM-1) and other TIM family members were recently identified as phosphatidylserine (PtdSer)-mediated virus entry-enhancing receptors (PVEERs)...
  30. Medić B, Rovčanin B, Basta Jovanović G, Radojević Škodrić S, Prostran M. Kidney Injury Molecule-1 and Cardiovascular Diseases: From Basic Science to Clinical Practice. Biomed Res Int. 2015;2015:854070 pubmed publisher
    ..The aim of this review article is to summarize the literature data concerning KIM-1 as a potential novel marker in the early diagnosis and prediction of clinical outcome of certain cardiovascular diseases. ..
  31. Mir M, Pavan N, Parekh D. Current Paradigm for Ischemia in Kidney Surgery. J Urol. 2016;195:1655-63 pubmed publisher
    ..Indications for partial nephrectomy could be significantly expanded as the safety of limited renal ischemia is now better understood. ..
  32. Hisamichi M, Kamijo Ikemori A, Sugaya T, Ichikawa D, Hoshino S, Hirata K, et al. Increase in urinary markers during the acute phase reflects the degree of chronic tubulointerstitial injury after ischemia-reperfusion renal injury. Biomarkers. 2017;22:5-13 pubmed publisher
    ..These markers could detect higher risk of progression to CKD. ..
  33. Cárdenas González M, Osorio Yáñez C, Gaspar Ramírez O, Pavkovic M, Ochoa Martinez A, López Ventura D, et al. Environmental exposure to arsenic and chromium in children is associated with kidney injury molecule-1. Environ Res. 2016;150:653-662 pubmed publisher
    ..We conclude that KIM-1 might serve as a sensitive biomarker to screen children for kidney damage induced by environmental toxic agents. ..
  34. Gunes A, Aktar F, Tan I, Soker M, Uluca U, Balik H, et al. Urinary levels of early kidney injury molecules in children with vitamin B12 deficiency. Arch Argent Pediatr. 2016;114:453-7 pubmed publisher
  35. Hsu C, Xie D, Waikar S, Bonventre J, Zhang X, Sabbisetti V, et al. Urine biomarkers of tubular injury do not improve on the clinical model predicting chronic kidney disease progression. Kidney Int. 2017;91:196-203 pubmed publisher
  36. Khan H, Singh R, Tiwari R, Gangopadhyay S, Roy S, SINGH D, et al. Mercury exposure induces cytoskeleton disruption and loss of renal function through epigenetic modulation of MMP9 expression. Toxicology. 2017;386:28-39 pubmed publisher
    ..Our studies thus show how MeHg could epigenetically modulate MMP9 to promote cytoskeleton disruption leading to loss of renal function. ..
  37. Seifert H, Benedek G, Nguyen H, Kent G, Vandenbark A, Offner H. Estrogen protects both sexes against EAE by promoting common regulatory cell subtypes independent of endogenous estrogen. Metab Brain Dis. 2017;32:1747-1754 pubmed publisher
    ..CD19+CD138+CD44hi and CD19+Tim-1+ Breg cells, CD8+CD122+ Treg cells and CD11b+CD 206+ARG-1<..
  38. Ahmad T, Jackson K, Rao V, Tang W, Brisco Bacik M, Chen H, et al. Worsening Renal Function in Patients With Acute Heart Failure Undergoing Aggressive Diuresis Is Not Associated With Tubular Injury. Circulation. 2018;137:2016-2028 pubmed publisher
    ..injury biomarkers, N-acetyl-β-d-glucosaminidase, neutrophil gelatinase-associated lipocalin, and kidney injury molecule 1, are now available that can quantify the degree of renal tubular injury...
  39. Chung H, Pellegrini K, Chung J, Wanigasuriya K, Jayawardene I, Lee K, et al. Nanoparticle Detection of Urinary Markers for Point-of-Care Diagnosis of Kidney Injury. PLoS ONE. 2015;10:e0133417 pubmed publisher
    ..Thus, we show that the μUNPD technology enables point of care and non-invasive detection of kidney injury, and has potential for applications in diagnosing kidney injury with high sensitivity in resource-limited settings. ..
  40. Shiozuru D, Ichii O, Kimura J, Nakamura T, Elewa Y, Otsuka Kanazawa S, et al. MRL/MpJ mice show unique pathological features after experimental kidney injury. Histol Histopathol. 2016;31:189-204 pubmed publisher
    ..histopathological injury scores and number of interleukin (IL)-1F6-positive damaged distal tubules and kidney injury molecule 1 (KIM-1)-positive damaged proximal tubules drastically increased 1 day after AKI induction...
  41. Wang N, Wang Z, Niu X, Yang X. Synthesis, characterization and anti-diabetic therapeutic potential of novel aminophenol-derivatized nitrilotriacetic acid vanadyl complexes. J Inorg Biochem. 2015;152:104-13 pubmed publisher
    ..In overall, the present results suggest VOphpada as a novel hypoglycemic agent with improved efficacy-over-toxicity index. ..
  42. Bansal N, Carpenter M, Weiner D, Levey A, Pfeffer M, Kusek J, et al. Urine Injury Biomarkers and Risk of Adverse Outcomes in Recipients of Prevalent Kidney Transplants: The Folic Acid for Vascular Outcome Reduction in Transplantation Trial. J Am Soc Nephrol. 2016;27:2109-21 pubmed publisher
    ..Urine L-FABP did not associate with any study outcomes. In conclusion, among prevalent KTRs, higher urine NGAL, KIM-1, and IL-18 levels independently and differentially associated with greater risk of adverse outcomes. ..
  43. Gu L, Zhang X, Xing W, Xu J, Lu H. Andrographolide-induced apoptosis in human renal tubular epithelial cells: Roles of endoplasmic reticulum stress and inflammatory response. Environ Toxicol Pharmacol. 2016;45:257-64 pubmed publisher
    ..It provided evidence that ER stress and inflammation would be significant mechanisms responsible for AD-induced apoptosis in addition to oxidative stress. ..
  44. Chen C, Yang X, Lei Y, Zha Y, Liu H, Ma C, et al. Urinary Biomarkers at the Time of AKI Diagnosis as Predictors of Progression of AKI among Patients with Acute Cardiorenal Syndrome. Clin J Am Soc Nephrol. 2016;11:1536-44 pubmed publisher
    ..uAGT, uNGAL, and uIL-18 measured at time of AKI diagnosis improved risk stratification and identified CRS patients at highest risk of adverse outcomes. ..
  45. Krievina G, Tretjakovs P, Skuja I, Silina V, Keisa L, Krievina D, et al. Ectopic Adipose Tissue Storage in the Left and the Right Renal Sinus is Asymmetric and Associated With Serum Kidney Injury Molecule-1 and Fibroblast Growth Factor-21 Levels Increase. EBioMedicine. 2016;13:274-283 pubmed publisher
    ..Thus, primarily RS adipose tissue effects should be assessed on the left kidney. Accumulation of adipose tissue in the RS is related with the visceral adipose amount, KIM-1 and FGF-21 concentration increase in the blood serum. ..
  46. Tasdemir M, Fuçucuoğlu D, Kucuk S, Erol M, Yiğit O, Bilge I. Urinary biomarkers in the early detection and follow-up of tubular injury in childhood urolithiasis. Clin Exp Nephrol. 2018;22:133-141 pubmed publisher
  47. Sangoi A, McKenney J, Brooks J, Bonventre J, Higgins J. Evaluation of putative renal cell carcinoma markers PAX-2, PAX-8, and hKIM-1 in germ cell tumors: a tissue microarray study of 100 cases. Appl Immunohistochem Mol Morphol. 2012;20:451-3 pubmed publisher
  48. Kristensen B, Hegedüs L, Lundy S, Brimnes M, Smith T, Nielsen C. Characterization of Regulatory B Cells in Graves' Disease and Hashimoto's Thyroiditis. PLoS ONE. 2015;10:e0127949 pubmed publisher
    ..IL-10+ B cells from both patient groups displayed CD25 or TIM-1 more frequently than did those from healthy donors...
  49. Stewart I, Glass K, Howard J, Morrow B, Sosnov J, Siew E, et al. The potential utility of urinary biomarkers for risk prediction in combat casualties: a prospective observational cohort study. Crit Care. 2015;19:252 pubmed publisher
    ..Larger multicenter studies will be required to determine how urinary biomarkers can best be used in future prediction models. ..
  50. Zhang J, Zeng H, Wang N, Tian X, Dou W, Shi P. Beneficial effects of creatine phosphate sodium for the treatment of Henoch-Schönlein purpura in patients with early renal damage detected using urinary kidney injury molecule-1 levels. Eur J Pediatr. 2016;175:49-55 pubmed publisher
    ..Preconditioning with CP may also be a useful adjunct for preventing early renal damage in HSPN patients. ..
  51. Deininger S, Hoenicka M, Müller Eising K, Rupp P, Liebold A, Koenig W, et al. Renal Function and Urinary Biomarkers in Cardiac Bypass Surgery: A Prospective Randomized Trial Comparing Three Surgical Techniques. Thorac Cardiovasc Surg. 2016;64:561-568 pubmed
    ..However, late changes of renal function parameters occur irrespective of extracorporeal perfusion mode and even in off-pump surgery. ..
  52. Funamoto M, Masumoto H, Takaori K, Taki T, Setozaki S, Yamazaki K, et al. Green Tea Polyphenol Prevents Diabetic Rats From Acute Kidney Injury After Cardiopulmonary Bypass. Ann Thorac Surg. 2016;101:1507-13 pubmed publisher
    ..This simple method could be applied in a clinical setting as a prophylactic renal protection against AKI after CPB, especially for high-risk patients with diabetes mellitus. ..
  53. Gerber C, Harel M, Lynch M, Herbst K, Ferrer F, Shapiro L. Proximal tubule proteins are significantly elevated in bladder urine of patients with ureteropelvic junction obstruction and may represent novel biomarkers: A pilot study. J Pediatr Urol. 2016;12:120.e1-7 pubmed publisher
    ..Proximal tubule brush border proteins are reliably detected in the urine of obstructed patients and may be more effective at predicting UPJO. ..
  54. Carter J, Parker C, Stevens P, Eaglestone G, Knight S, Farmer C, et al. Biological Variation of Plasma and Urinary Markers of Acute Kidney Injury in Patients with Chronic Kidney Disease. Clin Chem. 2016;62:876-83 pubmed publisher
    ..lipocalin (111%, 59%, and 693%, respectively), plasma cystatin C (14%), creatinine (17%), and urinary kidney injury molecule 1 (497%), tissue inhibitor of metalloproteinases 2 (454%), N-acetyl-?-d-glucosaminidase (361%), interleukin-..
  55. Tuuminen R, Jouppila A, Salvail D, Laurent C, Benoit M, Syrjälä S, et al. Dual antiplatelet and anticoagulant APAC prevents experimental ischemia-reperfusion-induced acute kidney injury. Clin Exp Nephrol. 2017;21:436-445 pubmed publisher
    ..APAC and UFH were similarly eliminated via kidneys and liver. In contrast to UFH, APAC (0.13 mg/kg) was reno-protective in moderate and even severe IRI by attenuating vascular injury and innate immune activation. ..
  56. Helmersson Karlqvist J, Arnlov J, Carlsson A, Lind L, Larsson A. Urinary KIM-1, but not urinary cystatin C, should be corrected for urinary creatinine. Clin Biochem. 2016;49:1164-1166 pubmed publisher
    ..This study supports the use of U-KIM-1/Cr ratio in clinical population studies. Data supporting the use of U-CysC/U-Cr ratio were less convincing and the possible confounding of UCr has to be acknowledged in clinical settings. ..
  57. Aggarwal D, Gautam D, Sharma M, Singla S. Bergenin attenuates renal injury by reversing mitochondrial dysfunction in ethylene glycol induced hyperoxaluric rat model. Eur J Pharmacol. 2016;791:611-621 pubmed publisher
    ..Hence, it presented itself as an effective remedy in combating urolithiasis. ..
  58. Dobrek Ł, Thor P. [Selected proteins as biomarkers of kidney injury used in the nephrological diagnosis]. Postepy Biochem. 2016;62:482-494 pubmed
  59. Mansour S, Verma G, Pata R, Martin T, Perazella M, Parikh C. Kidney Injury and Repair Biomarkers in Marathon Runners. Am J Kidney Dis. 2017;70:252-261 pubmed publisher
    ..6 injury urine biomarkers (IL-6, IL-8, IL-18, kidney injury molecule 1, neutrophil gelatinase-associated lipocalin, and tumor necrosis factor ?) and 2 repair urine biomarkers (..
  60. Hu Y, Yu P, Yu X, Hu X, Kawai T, Han X. IL-21/anti-Tim1/CD40 ligand promotes B10 activity in vitro and alleviates bone loss in experimental periodontitis in vivo. Biochim Biophys Acta Mol Basis Dis. 2017;1863:2149-2157 pubmed publisher
    ..were isolated from C57BL/6J mice and cultured for 48h under the following conditions: control, CD40L, IL-21, anti-Tim1, CD40L+IL-21, CD40L+anti-Tim1, CD40L+IL-21+anti-Tim1...
  61. Tavernier Q, Tinel C, Rabant M, Morin L, Anglicheau D, Pallet N. A Comparative Study of the Predictive Values of Urinary Acute Kidney Injury Markers Angiogenin and Kidney Injury Molecule 1 for the Outcomes of Kidney Allografts. Transplant Direct. 2017;3:e204 pubmed publisher
    ..Whether injury-related molecules in urines of individuals with ischemia-reperfusion injury (IRI) are independent predictors of graft outcomes and provide additional information compared with usual risk factors remains to be established...
  62. Nagase M, Kurihara H, Aiba A, Young M, Sakai T. Deletion of Rac1GTPase in the Myeloid Lineage Protects against Inflammation-Mediated Kidney Injury in Mice. PLoS ONE. 2016;11:e0150886 pubmed publisher
    ..Our data suggest that Rac1 in macrophage is a novel target for the treatment of kidney disease through inhibition of cytokine production. ..
  63. Downes K, Dong M, Fukuda T, Clancy J, Haffner C, Bennett M, et al. Urinary kidney injury biomarkers and tobramycin clearance among children and young adults with cystic fibrosis: a population pharmacokinetic analysis. J Antimicrob Chemother. 2017;72:254-260 pubmed
    ..Our findings suggest that patient weight and urinary NGAL or RBP could be used to individualize tobramycin therapy in patients with CF. ..
  64. Ascher S, Scherzer R, Peralta C, Tien P, Grunfeld C, Estrella M, et al. Association of Kidney Function and Early Kidney Injury With Incident Hypertension in HIV-Infected Women. Hypertension. 2017;69:304-313 pubmed publisher
    ..The associations of tubular markers with hypertension in HIV-uninfected women should be validated in other studies. ..
  65. Maeda A, Ando H, Ura T, Muro K, Aoki M, Saito K, et al. Differences in Urinary Renal Failure Biomarkers in Cancer Patients Initially Treated with Cisplatin. Anticancer Res. 2017;37:5235-5239 pubmed
    ..Conversely, all markers were significantly higher 5 days after receiving chemotherapy in the CDDP group when compared to baseline. Urinary NAG, Kim-1, and NGAL can detect renal injury more sensitively than sCr. ..
  66. Kim K, Lim H, Lim J, Son J, Lee J, Lee B, et al. Curcumin ameliorates cadmium-induced nephrotoxicity in Sprague-Dawley rats. Food Chem Toxicol. 2018;114:34-40 pubmed publisher
    ..The administration of curcumin provided a significant protective effect against Cd-induced nephrotoxicity. ..
  67. Furuya S, Chappell G, Iwata Y, Uehara T, Kato Y, Kono H, et al. A mouse model of alcoholic liver fibrosis-associated acute kidney injury identifies key molecular pathways. Toxicol Appl Pharmacol. 2016;310:129-139 pubmed publisher
    ..Interestingly, Havcr1 and Lcn2, biomarkers of AKI, were markedly up-regulated. Overall, this study established a novel mouse model of fibrosis- and alcohol-associated AKI and identified key mechanistic pathways. ..
  68. Opotowsky A, Baraona F, Mc Causland F, Loukas B, Landzberg E, Landzberg M, et al. Estimated glomerular filtration rate and urine biomarkers in patients with single-ventricle Fontan circulation. Heart. 2017;103:434-442 pubmed publisher
    ..The Fontan circulation is commonly associated with reduced estimated GFR and evidence for glomerular and tubular injury. Those with lower cystatin C GFR and tubular injury are at increased risk of adverse outcomes. ..
  69. Chuang K, Pan C, Su C, Lai C, Lin W, Ma C, et al. Urinary neutrophil gelatinase-associated lipocalin is associated with heavy metal exposure in welding workers. Sci Rep. 2015;5:18048 pubmed publisher
    ..657, p < 0.001) than was KIM-1, suggesting that NGAL may be a urinary biomarker for welding PM2.5 exposure. Nephrotoxicity (e.g., renal tubular injury) may be an emerging concern in occupational health. ..
  70. Kim H, Eyheramonho M, Pichavant M, Gonzalez Cambaceres C, Matangkasombut P, Cervio G, et al. A polymorphism in TIM1 is associated with susceptibility to severe hepatitis A virus infection in humans. J Clin Invest. 2011;121:1111-8 pubmed publisher
    ..We found that HAV-induced severe liver disease was associated with a 6-amino-acid insertion in TIM1/HAVCR1 (157insMTTTVP), the gene encoding the HAV receptor...
  71. Wichukchinda N, Nakajima T, Saipradit N, Nakayama E, Ohtani H, Rojanawiwat A, et al. TIM1 haplotype may control the disease progression to AIDS in a HIV-1-infected female cohort in Thailand. AIDS. 2010;24:1625-31 pubmed publisher
    To investigate association of TIM1 sequence variations with HIV/AIDS progression. : HIV-1 infected individuals have wide variations in disease progression including AIDS...
  72. Kishimoto W, Nishikori M, Arima H, Miyoshi H, Sasaki Y, Kitawaki T, et al. Expression of Tim-1 in primary CNS lymphoma. Cancer Med. 2016;5:3235-3245 pubmed publisher
    ..We intended in this study to clarify whether Tim-1, a molecule known as a marker for regulatory B cells in mice, is expressed in PCNSL...
  73. Das A, Hirai Yuki A, Gonzalez Lopez O, Rhein B, Moller Tank S, Brouillette R, et al. TIM1 (HAVCR1) Is Not Essential for Cellular Entry of Either Quasi-enveloped or Naked Hepatitis A Virions. MBio. 2017;8: pubmed publisher
    ..A virus (HAV), a picornavirus in the Hepatovirus genus, resulting in its designation as "hepatitis A virus cellular receptor 1" (HAVCR1) by the Human Genome Organization Gene Nomenclature Committee...
  74. Zhao X, Jiang C, Olufade R, Liu D, Emmett N. Kidney Injury Molecule-1 Enhances Endocytosis of Albumin in Renal Proximal Tubular Cells. J Cell Physiol. 2016;231:896-907 pubmed publisher
    ..Taken together, our data indicate that KIM-1 increases albumin endocytosis in renal tubule epithelial cells, at least partially via a clathrin-dependent mechanism. J. Cell. Physiol. 231: 896-907, 2016. © 2015 Wiley Periodicals, Inc. ..
  75. Aydin H, Irkilata L, Aydin M, Dağgülli M, Taskin M, Demirel H, et al. The Application of Kidney Injury Molecule-1 to Determine the Duration Between Shockwave Lithotripsy Sessions. J Endourol. 2016;30:109-13 pubmed publisher
    ..KIM-1 is a noninvasive biomarker that may be used to show renal damage because of stones and early-stage renal damage linked to SWL. In addition, post-SWL KIM-1 values may be used to determine the interval between SWL sessions. ..
  76. Sayanthooran S, Magana Arachchi D, Gunerathne L, Abeysekera T. Potential diagnostic biomarkers for chronic kidney disease of unknown etiology (CKDu) in Sri Lanka: a pilot study. BMC Nephrol. 2017;18:31 pubmed publisher
    ..012) and kidney injury molecule-1 (KIM1; p = 0...
  77. Wang Y, Meng J, Wang X, Liu S, Shu Q, Gao L, et al. Expression of human TIM-1 and TIM-3 on lymphocytes from systemic lupus erythematosus patients. Scand J Immunol. 2008;67:63-70 pubmed
    ..b>TIM-3 is expressed on T helper type 1 (Th1) cells and implicated in the pathogenesis of Th1-driven auto- and allo-..
  78. Rhein B, Brouillette R, Schaack G, Chiorini J, Maury W. Characterization of Human and Murine T-Cell Immunoglobulin Mucin Domain 4 (TIM-4) IgV Domain Residues Critical for Ebola Virus Entry. J Virol. 2016;90:6097-6111 pubmed publisher
    ..The PtdSer receptors human and murine T-cell immunoglobulin mucin (TIM) domain proteins TIM-1 and TIM-4 mediate filovirus entry by binding to PtdSer on the virion surface via a conserved ..
  79. Loeffler I, Liebisch M, Allert S, Kunisch E, Kinne R, Wolf G. FSP1-specific SMAD2 knockout in renal tubular, endothelial, and interstitial cells reduces fibrosis and epithelial-to-mesenchymal transition in murine STZ-induced diabetic nephropathy. Cell Tissue Res. 2018;372:115-133 pubmed publisher
    ..mice, diabetic SMAD2 knockout mice showed the following features: (1) significantly reduced DN and TIF (shown by KIM1 expression; periodic acid Schiff staining; collagen I and III, fibronectin, and connective tissue growth factor ..
  80. McIntire J, Umetsu S, Macaubas C, Hoyte E, Cinnioglu C, Cavalli Sforza L, et al. Immunology: hepatitis A virus link to atopic disease. Nature. 2003;425:576 pubmed
  81. Jemielity S, Wang J, Chan Y, Ahmed A, Li W, Monahan S, et al. TIM-family proteins promote infection of multiple enveloped viruses through virion-associated phosphatidylserine. PLoS Pathog. 2013;9:e1003232 pubmed publisher
    Human T-cell Immunoglobulin and Mucin-domain containing proteins (TIM1, 3, and 4) specifically bind phosphatidylserine (PS)...
  82. Eltounali S, Moodley J, Naicker T. Role of kidney biomarkers [Kidney injury molecule-1, Calbindin, Interleukin-18 and Monocyte chemoattractant protein-1] in HIV associated pre-eclampsia. Hypertens Pregnancy. 2017;36:288-294 pubmed publisher
    ..We propose that studies with larger sample sizes using these markers be conducted to establish their use as markers of diagnosing kidney injury in PE. ..
  83. Vila M, Kaplan G, Feigelstock D, Nadal M, Morote J, Porta R, et al. Hepatitis A virus receptor blocks cell differentiation and is overexpressed in clear cell renal cell carcinoma. Kidney Int. 2004;65:1761-73 pubmed
    ..This work reports on the identification of human hepatitis A virus cellular receptor 1 (hHAVcr-1) as a differentially expressed gene in ccRCC using RNA-based arbitrarily primed ..
  84. Li W, Chen G, Yuan H, Yao Y, Li R, Pan H, et al. Polymorphisms of the TIM-1 and TIM-3 genes are not associated with systemic lupus erythematosus in a Chinese population. Mutagenesis. 2011;26:507-11 pubmed publisher
    ..The T-cell immunoglobulin mucin (TIM) proteins comprise a family of cell surface molecules expressed on T cells that regulate Th1- and Th2-cell-mediated ..
  85. Aravena O, Ferrier A, Menon M, Mauri C, Aguillon J, Soto L, et al. TIM-1 defines a human regulatory B cell population that is altered in frequency and function in systemic sclerosis patients. Arthritis Res Ther. 2017;19:8 pubmed publisher
    ..It has been described in mice that T cell Ig and mucin domain protein 1 (TIM-1) is an inclusive marker for Bregs, and that TIM-1+ B cells are able to prevent the development of autoimmunity...
  86. Gu X, He H, Lin L, Luo G, Wen Y, Xiang D, et al. Tim-1+ B cells suppress T cell interferon-gamma production and promote Foxp3 expression, but have impaired regulatory function in coronary artery disease. APMIS. 2017;125:872-879 pubmed publisher
    ..Here, we investigated one subset of Bregs, Tim-1+ B cell, and its role in atherosclerosis and CAD patients...
  87. Belcher J, Sanyal A, Peixoto A, Perazella M, Lim J, Thiessen Philbrook H, et al. Kidney biomarkers and differential diagnosis of patients with cirrhosis and acute kidney injury. Hepatology. 2014;60:622-32 pubmed publisher
    ..Further research is required to document biomarkers specific to HRS. ..
  88. Wen Y, Li Z, Chang C, Zhang P, Lyu Y. [Diagnostic significance of urinary neutrophil gelatin enzyme-related lipid delivery protein and kidney injury molecule-1 in acute kidney injury after cardiac operation with cardiopulmonary bypass operation in children]. Zhonghua Wei Zhong Bing Ji Jiu Yi Xue. 2017;29:1112-1116 pubmed publisher
    ..90 μmol/L, the sensitivity was 90.6%, the specificity was 95.0%, and the accuracy was 95.7%. Urine NGAL and KIM-1 can be used as biomarkers for early diagnosis of AKI after CPB for the non-cyanotic CHD in children. ..
  89. Egli P, Aeschbacher S, Bossard M, Eggimann L, Blum S, Meyre P, et al. Relationships of kidney injury molecule-1 with renal function and cardiovascular risk factors in the general population. Clin Chim Acta. 2018;478:13-17 pubmed publisher
    ..12 (0.07; 0.17), p<0.0001). Among healthy adults from the general population, plasma levels of KIM-1 were not associated with renal function but were independently related to multiple cardiovascular risk factors. ..
  90. McWilliam S, Antoine D, Smyth R, Pirmohamed M. Aminoglycoside-induced nephrotoxicity in children. Pediatr Nephrol. 2017;32:2015-2025 pubmed publisher
    ..Recommendations for future directions are provided. ..
  91. Sivertsson E, Friederich Persson M, Oberg C, Fasching A, Hansell P, Rippe B, et al. Inhibition of mammalian target of rapamycin decreases intrarenal oxygen availability and alters glomerular permeability. Am J Physiol Renal Physiol. 2017;:ajprenal.00033.2017 pubmed publisher
    ..Since hypoxia has been suggested as a common pathway to development of chronic kidney disease, mTOR inhibition to patients with pre-existing nephropathy should be used with caution since it may accelerate the progression of disease...
  92. Fufaa G, Weil E, Nelson R, Hanson R, Bonventre J, Sabbisetti V, et al. Association of urinary KIM-1, L-FABP, NAG and NGAL with incident end-stage renal disease and mortality in American Indians with type 2 diabetes mellitus. Diabetologia. 2015;58:188-98 pubmed publisher
    b>Kidney injury molecule 1 (KIM-1), liver fatty acid-binding protein (L-FABP), N-acetyl-β-D-glucosaminidase (NAG) and neutrophil gelatinase-associated lipocalin (NGAL) are urinary biomarkers of renal tubular injury...