KIF5C

Summary

Gene Symbol: KIF5C
Description: kinesin family member 5C
Alias: CDCBM2, KINN, NKHC, NKHC-2, NKHC2, kinesin heavy chain isoform 5C, kinesin heavy chain, kinesin heavy chain neuron-specific 2
Species: human
Products:     KIF5C

Top Publications

  1. Di Donato N, Timms A, Aldinger K, Mirzaa G, Bennett J, Collins S, et al. Analysis of 17 genes detects mutations in 81% of 811 patients with lissencephaly. Genet Med. 2018;20:1354-1364 pubmed publisher
    ..targeted panel of 17 genes (ACTB, ACTG1, ARX, CRADD, DCX, LIS1, TUBA1A, TUBA8, TUBB2B, TUBB, TUBB3, TUBG1, KIF2A, KIF5C, DYNC1H1, RELN, and VLDLR) or by whole-exome sequencing...
  2. Almeida J, Costa J, Coelho P, Cea V, Galesio M, Noronha J, et al. Adipocyte proteome and secretome influence inflammatory and hormone pathways in glioma. Metab Brain Dis. 2019;34:141-152 pubmed publisher
    ..Contrariwise, RFC1, KIF5C, ANXA2, N-RAP and RACK1 are overexpressed in GL261 cell the in the presence of the adipokines-enriched medium...
  3. Heisler F, Pechmann Y, Wieser I, Altmeppen H, Veenendaal L, Muhia M, et al. Muskelin Coordinates PrPC Lysosome versus Exosome Targeting and Impacts Prion Disease Progression. Neuron. 2018;99:1155-1169.e9 pubmed publisher
    ..PrPC associates with muskelin, dynein, and KIF5C at transport vesicles...
  4. Morikawa M, Yajima H, Nitta R, Inoue S, Ogura T, Sato C, et al. X-ray and Cryo-EM structures reveal mutual conformational changes of Kinesin and GTP-state microtubules upon binding. EMBO J. 2015;34:1270-86 pubmed publisher
    ..In neurons, kinesin-1/KIF5C preferentially binds to the GTP-state microtubules over GDP-state microtubules to selectively enter an axon among ..
  5. Jamuar S, Lam A, Kircher M, D Gama A, Wang J, Barry B, et al. Somatic mutations in cerebral cortical malformations. N Engl J Med. 2014;371:733-43 pubmed publisher
    ..We found potentially causal mutations in the candidate genes DYNC1H1, KIF5C, and other kinesin genes in persons with pachygyria...
  6. Baxter P, Lin Q, Mao H, Kogiso M, Zhao X, Liu Z, et al. Silencing BMI1 eliminates tumor formation of pediatric glioma CD133+ cells not by affecting known targets but by down-regulating a novel set of core genes. Acta Neuropathol Commun. 2014;2:160 pubmed publisher
    ..the activated BMI1, but modulated a novel set of core genes, including RPS6KA2, ALDH3A2, FMFB, DTL, API5, EIF4G2, KIF5c, LOC650152, C20ORF121, LOC203547, LOC653308, and LOC642489, to mediate the elimination of tumor formation...
  7. DuRaine G, Wisner T, Howard P, Johnson D. Kinesin-1 Proteins KIF5A, -5B, and -5C Promote Anterograde Transport of Herpes Simplex Virus Enveloped Virions in Axons. J Virol. 2018;92: pubmed publisher
    ..Fluorescent kinesin-1 protein KIF5C extensively colocalized with HSV particles, while fluorescent kinesin-1 KIF1A did not...
  8. Liu X, Kadakkuzha B, Pascal B, Steckler C, Akhmedov K, Yan L, et al. New approach to capture and characterize synaptic proteome. Proc Natl Acad Sci U S A. 2014;111:16154-9 pubmed publisher
    ..We used this approach to identify and compare proteins transported to synapses by kinesin (Kif) complexes Kif5C and Kif3A in the mouse hippocampus and prefrontal cortex...
  9. Shaydurov V, Kasianov A, Bolshakov A. Analysis of Housekeeping Genes for Accurate Normalization of qPCR Data During Early Postnatal Brain Development. J Mol Neurosci. 2018;64:431-439 pubmed publisher
    ..as well as a novel approach, we compared stability of expression of GAPDH, YWHAZ, TFR1, RPS18, Rn18S, HPRT1, KIF5C, OSBP, and UQCRFS1...

More Information

Publications28

  1. Oksdath M, Guil A, Grassi D, Sosa L, Quiroga S. The Motor KIF5C Links the Requirements of Stable Microtubules and IGF-1 Receptor Membrane Insertion for Neuronal Polarization. Mol Neurobiol. 2017;54:6085-6096 pubmed publisher
    ..enrichment of the plasma membrane with activatable IGF-1r, and (iii) polarized transport of the microtubular motor KIF5C. Here, we studied the possible relationship between these three phenomena...
  2. Bergen S, O Dushlaine C, Lee P, Fanous A, Ruderfer D, Ripke S, et al. Genetic modifiers and subtypes in schizophrenia: investigations of age at onset, severity, sex and family history. Schizophr Res. 2014;154:48-53 pubmed publisher
    ..002). Family history positive analyses showed the greatest association with KIF5C (p=1.96×10(-8)), however, genetic risk burden overall does not differ by family history...
  3. Iworima D, Pasqualotto B, Rintoul G. Kif5 regulates mitochondrial movement, morphology, function and neuronal survival. Mol Cell Neurosci. 2016;72:22-33 pubmed publisher
    ..We evaluated the consequences of disrupted kif5c-mediated mitochondrial trafficking on mitochondrial form and function in primary rat cortical neurons...
  4. Baguma Nibasheka M, Fracassi A, Costain W, Moreno S, Kablar B. Role of skeletal muscle in motor neuron development. Histol Histopathol. 2016;31:699-719 pubmed publisher
    ..Several follow-up steps revealed that Kif5c, Stxbp1 and Polb, differentially expressed in the MyoD-/- limb muscle, and Ppargc1a, Glrb and Hoxd10, ..
  5. Padzik A, Deshpande P, Hollos P, Franker M, Rannikko E, Cai D, et al. KIF5C S176 Phosphorylation Regulates Microtubule Binding and Transport Efficiency in Mammalian Neurons. Front Cell Neurosci. 2016;10:57 pubmed publisher
    ..JNK phosphorylates KIF5C on S176 in the motor domain; a site that we show is phosphorylated in brain...
  6. Willemsen M, Ba W, Wissink Lindhout W, de Brouwer A, Haas S, Bienek M, et al. Involvement of the kinesin family members KIF4A and KIF5C in intellectual disability and synaptic function. J Med Genet. 2014;51:487-94 pubmed publisher
    ..applying next-generation sequencing (NGS) in ID patients, we identified likely pathogenic mutations in KIF4A and KIF5C. To further confirm the pathogenicity of these mutations, we performed functional studies at the level of synaptic ..
  7. Chen Q, Hao W, Xiao C, Wang R, Xu X, Lu H, et al. SIRT6 Is Essential for Adipocyte Differentiation by Regulating Mitotic Clonal Expansion. Cell Rep. 2017;18:3155-3166 pubmed publisher
    ..Analysis of gene expression during adipogenesis reveals that KIF5C, which belongs to the kinesin family, is negatively regulated by SIRT6...
  8. Engelender S, Sharp A, Colomer V, Tokito M, Lanahan A, Worley P, et al. Huntingtin-associated protein 1 (HAP1) interacts with the p150Glued subunit of dynactin. Hum Mol Genet. 1997;6:2205-12 pubmed
    ..Thus, HAP1 and huntingtin may play a role in vesicle trafficking within the cell and disruption of this function could contribute to the neuronal dysfunction and death seen in HD. ..
  9. Cho K, Cai Y, Yi H, Yeh A, Aslanukov A, Ferreira P. Association of the kinesin-binding domain of RanBP2 to KIF5B and KIF5C determines mitochondria localization and function. Traffic. 2007;8:1722-35 pubmed
    ..in the central nervous system (CNS), and directly, with the ubiquitous and CNS-specific kinesins, KIF5B and KIF5C, respectively, but not with the highly homologous KIF5A...
  10. Rahman A, Friedman D, Goldstein L. Two kinesin light chain genes in mice. Identification and characterization of the encoded proteins. J Biol Chem. 1998;273:15395-403 pubmed
    ..The presence of multiple kinesin light chain genes in mice is especially interesting, since there are two kinesin heavy chain genes in humans (Niclas, J., Navone, F., Hom-Booher, N., and Vale, R. D. (1994) Neuron 12, 1059-1072)...
  11. Michels S, Foss K, Park K, Golden Grant K, Saneto R, Lopez J, et al. Mutations of KIF5C cause a neurodevelopmental disorder of infantile-onset epilepsy, absent language, and distinctive malformations of cortical development. Am J Med Genet A. 2017;173:3127-3131 pubmed publisher
    ..Here, we report two individuals with the same de novo KIF5C mutation who present with subtle MCDs, early onset epilepsy and significant neurodevelopmental and behavioral ..
  12. Kuźma Kozakiewicz M, Kaźmierczak B, Chudy A, Gajewska B, Barańczyk Kuźma A. Alteration of Motor Protein Expression Involved in Bidirectional Transport in Peripheral Blood Mononuclear Cells of Patients with Amyotrophic Lateral Sclerosis. Neurodegener Dis. 2016;16:235-44 pubmed publisher
    ..We evaluated the expression of motor proteins involved in the anterograde (kinesins KIF1B, KIF5C) and retrograde (KIFC3, dynactin subunits DCTN1 and DCTN3) intracellular transport in peripheral blood mononuclear ..
  13. Niclas J, Navone F, Hom Booher N, Vale R. Cloning and localization of a conventional kinesin motor expressed exclusively in neurons. Neuron. 1994;12:1059-72 pubmed
    ..motor has been thought to serve all cell types, we document here that neurons express a second conventional kinesin heavy chain (nKHC) that is 65% identical in amino acid sequence to the ubiquitously expressed kinesin heavy chain (uKHC)..
  14. Smith M, Pozo K, Brickley K, Stephenson F. Mapping the GRIF-1 binding domain of the kinesin, KIF5C, substantiates a role for GRIF-1 as an adaptor protein in the anterograde trafficking of cargoes. J Biol Chem. 2006;281:27216-28 pubmed
    ..Here we have studied in more detail the interaction between the prototypic kinesin heavy chain, KIF5C, kinesin light chain, and GRIF-1...
  15. Wang X, Schwarz T. The mechanism of Ca2+ -dependent regulation of kinesin-mediated mitochondrial motility. Cell. 2009;136:163-74 pubmed publisher
    ..Disrupting Ca(2+)-dependent regulation diminishes neuronal resistance to excitotoxicity. ..
  16. Schafer B, Gotz C, Dudek J, Hessenauer A, Matti U, Montenarh M. KIF5C: a new binding partner for protein kinase CK2 with a preference for the CK2alpha' subunit. Cell Mol Life Sci. 2009;66:339-49 pubmed publisher
    ..We identified the motor neuron protein KIF5C as a new binding partner for CK2...
  17. Schäfer B, Götz C, Montenarh M. The kinesin I family member KIF5C is a novel substrate for protein kinase CK2. Biochem Biophys Res Commun. 2008;375:179-83 pubmed publisher
    ..Here, we report a new substrate, KIF5C, which is a member of the kinesin 1 family of motor neuron proteins...
  18. Brickley K, Smith M, Beck M, Stephenson F. GRIF-1 and OIP106, members of a novel gene family of coiled-coil domain proteins: association in vivo and in vitro with kinesin. J Biol Chem. 2005;280:14723-32 pubmed
    ..GRIF-1 and OIP106 were shown by co-immunoprecipitation to be specifically associated with an endogenous kinesin heavy chain species of 115 kDa and exogenous KIF5C...
  19. Xia C, Rahman A, Yang Z, Goldstein L. Chromosomal localization reveals three kinesin heavy chain genes in mouse. Genomics. 1998;52:209-13 pubmed
    ..The kinesin superfamily was first defined by kinesin heavy chain, which is the principal component of "true" kinesin...