Gene Symbol: KIF5B
Description: kinesin family member 5B
Alias: HEL-S-61, KINH, KNS, KNS1, UKHC, kinesin-1 heavy chain, conventional kinesin heavy chain, epididymis secretory protein Li 61, kinesin 1 (110-120kD), kinesin heavy chain, ubiquitous kinesin heavy chain
Species: human
Products:     KIF5B

Top Publications

  1. Navone F, Niclas J, Hom Booher N, Sparks L, Bernstein H, McCaffrey G, et al. Cloning and expression of a human kinesin heavy chain gene: interaction of the COOH-terminal domain with cytoplasmic microtubules in transfected CV-1 cells. J Cell Biol. 1992;117:1263-75 pubmed
    ..between the microtubule-based motor protein kinesin and intracellular components, we have expressed the kinesin heavy chain and its different domains in CV-1 monkey kidney epithelial cells and examined their distributions by ..
  2. Schepis A, Stauber T, Krijnse Locker J. Kinesin-1 plays multiple roles during the vaccinia virus life cycle. Cell Microbiol. 2007;9:1960-73 pubmed
    ..In the present study we present a novel kinesin-1 construct, encompassing the first 330 amino acids of kinesin heavy chain fused to GFP (kin330-GFP) that does not alter microtubules upon its overexpression...
  3. Tanaka Y, Kanai Y, Okada Y, Nonaka S, Takeda S, Harada A, et al. Targeted disruption of mouse conventional kinesin heavy chain, kif5B, results in abnormal perinuclear clustering of mitochondria. Cell. 1998;93:1147-58 pubmed
    ..5-11.5 days postcoitum. To analyze the significance of this conventional kinesin heavy chain in organelle transport, we studied the distribution of major organelles in the extraembryonic cells...
  4. Setou M, Seog D, Tanaka Y, Kanai Y, Takei Y, Kawagishi M, et al. Glutamate-receptor-interacting protein GRIP1 directly steers kinesin to dendrites. Nature. 2002;417:83-7 pubmed
    ..These results indicate that directly binding proteins can determine the traffic direction of a motor protein. ..
  5. Brickley K, Smith M, Beck M, Stephenson F. GRIF-1 and OIP106, members of a novel gene family of coiled-coil domain proteins: association in vivo and in vitro with kinesin. J Biol Chem. 2005;280:14723-32 pubmed
    ..GRIF-1 and OIP106 were shown by co-immunoprecipitation to be specifically associated with an endogenous kinesin heavy chain species of 115 kDa and exogenous KIF5C...
  6. Wong D, Leung E, Wong S, Tin V, Sihoe A, Cheng L, et al. A novel KIF5B-ALK variant in nonsmall cell lung cancer. Cancer. 2011;117:2709-18 pubmed publisher
    ..The authors identified a novel gene resulting from the fusion of kinesin family member 5B (KIF5B) exon 15 to ALK exon 20 in a primary lung adenocarcinoma...
  7. Kohno T, Ichikawa H, Totoki Y, Yasuda K, Hiramoto M, Nammo T, et al. KIF5B-RET fusions in lung adenocarcinoma. Nat Med. 2012;18:375-7 pubmed publisher
    We identified in-frame fusion transcripts of KIF5B (the kinesin family 5B gene) and the RET oncogene, which are present in 1-2% of lung adenocarcinomas (LADCs) from people from Japan and the United States, using whole-transcriptome ..
  8. Cai W, Su C, Li X, Fan L, Zheng L, Fei K, et al. KIF5B-RET fusions in Chinese patients with non-small cell lung cancer. Cancer. 2013;119:1486-94 pubmed publisher
    ..The objective of the current study was to determine the prevalence and clinicopathologic characteristics of KIF5B-RET fusions (fusions of the RET and kinesin family member 5B [KIF5B] genes) in Chinese patients with NSCLC...
  9. Niclas J, Navone F, Hom Booher N, Vale R. Cloning and localization of a conventional kinesin motor expressed exclusively in neurons. Neuron. 1994;12:1059-72 pubmed
    ..motor has been thought to serve all cell types, we document here that neurons express a second conventional kinesin heavy chain (nKHC) that is 65% identical in amino acid sequence to the ubiquitously expressed kinesin heavy chain ..

More Information

Publications115 found, 100 shown here

  1. Su Q, Cai Q, Gerwin C, Smith C, Sheng Z. Syntabulin is a microtubule-associated protein implicated in syntaxin transport in neurons. Nat Cell Biol. 2004;6:941-53 pubmed
    ..These findings suggest that syntabulin functions as a linker molecule that attaches syntaxin-cargo vesicles to kinesin I, enabling the transport of syntaxin-1 to neuronal processes. ..
  2. Boucrot E, Henry T, Borg J, Gorvel J, Méresse S. The intracellular fate of Salmonella depends on the recruitment of kinesin. Science. 2005;308:1174-8 pubmed
    ..Among these effectors, SifA targeted SKIP, a host protein that down-regulated the recruitment of kinesin on the bacterial vacuole and, in turn, controlled vacuolar membrane dynamics. ..
  3. Cho K, Cai Y, Yi H, Yeh A, Aslanukov A, Ferreira P. Association of the kinesin-binding domain of RanBP2 to KIF5B and KIF5C determines mitochondria localization and function. Traffic. 2007;8:1722-35 pubmed
    ..selectively in the central nervous system (CNS), and directly, with the ubiquitous and CNS-specific kinesins, KIF5B and KIF5C, respectively, but not with the highly homologous KIF5A...
  4. Jaulin F, Xue X, Rodriguez Boulan E, Kreitzer G. Polarization-dependent selective transport to the apical membrane by KIF5B in MDCK cells. Dev Cell. 2007;13:511-22 pubmed
    ..We demonstrate that KIF5B mediates post-Golgi transport of an apical protein in epithelial cells, but only after polarity has developed...
  5. Kull F, Sablin E, Lau R, Fletterick R, Vale R. Crystal structure of the kinesin motor domain reveals a structural similarity to myosin. Nature. 1996;380:550-5 pubmed
  6. Rahman A, Friedman D, Goldstein L. Two kinesin light chain genes in mice. Identification and characterization of the encoded proteins. J Biol Chem. 1998;273:15395-403 pubmed
    ..The presence of multiple kinesin light chain genes in mice is especially interesting, since there are two kinesin heavy chain genes in humans (Niclas, J., Navone, F., Hom-Booher, N., and Vale, R. D. (1994) Neuron 12, 1059-1072)...
  7. Kanai Y, Okada Y, Tanaka Y, Harada A, Terada S, Hirokawa N. KIF5C, a novel neuronal kinesin enriched in motor neurons. J Neurosci. 2000;20:6374-84 pubmed
    ..chains of conventional kinesin (KHC), are originally identified members of KIFs, and neuronal KIF5A and ubiquitous KIF5B have been identified so far...
  8. Piton N, Ruminy P, Gravet C, Marchand V, Colasse É, Lamy A, et al. Ligation-dependent RT-PCR: a new specific and low-cost technique to detect ALK, ROS, and RET rearrangements in lung adenocarcinoma. Lab Invest. 2017;: pubmed publisher
    ..cases (gene partners: CD74 in 8 cases and SLC34A2 in 1 case) and 1 (100%) in the single RET case (gene partner: KIF5B). No rearrangement was found in the 14 negative control cases...
  9. Santos Ledo A, García Macia M, Campbell P, Gronska M, Marlow F. Kinesin-1 promotes chondrocyte maintenance during skeletal morphogenesis. PLoS Genet. 2017;13:e1006918 pubmed publisher
    ..Chimeric and mosaic analyses indicate that Kif5B functions cell-autonomously in secretion, nuclear position, cell elongation and maintenance of hypertrophic ..
  10. Dacic S, Luvison A, Evdokimova V, Kelly L, Siegfried J, Villaruz L, et al. RET rearrangements in lung adenocarcinoma and radiation. J Thorac Oncol. 2014;9:118-20 pubmed publisher
    ..All fusions identified were between RET and KIF5B genes, and no RET fusions to CCDC6 or NCOA4 genes, characteristic for thyroid cancer, were identified in the ..
  11. Nguyen K, Abdelkreem E, Colombo R, Hasegawa Y, Can N, Bui T, et al. Characterization and outcome of 41 patients with beta-ketothiolase deficiency: 10 years' experience of a medical center in northern Vietnam. J Inherit Metab Dis. 2017;40:395-401 pubmed publisher
    ..622C>T) are consistent with an ancient common founder of mutation-bearing chromosomes belonging to the Kinh ethnic population...
  12. Saiki M, Kitazono S, Yoshizawa T, Dotsu Y, Ariyasu R, Koyama J, et al. Characterization of Computed Tomography Imaging of Rearranged During Transfection-rearranged Lung Cancer. Clin Lung Cancer. 2018;19:435-440.e1 pubmed publisher
    ..The fusion partner genes were identified as KIF5B (57%), CCDC6 (19%), and unknown (24%)...
  13. Novas R, Cardenas Rodriguez M, Lepanto P, Fabregat M, Rodao M, Fariello M, et al. Kinesin 1 regulates cilia length through an interaction with the Bardet-Biedl syndrome related protein CCDC28B. Sci Rep. 2018;8:3019 pubmed publisher
    ..CCDC28B interacts with kinesin light chain 1 (KLC1) and the heavy chain KIF5B. Notably, depletion of these kinesin 1 components results in abnormally elongated cilia...
  14. Wang R, Hu H, Pan Y, Li Y, Ye T, Li C, et al. RET fusions define a unique molecular and clinicopathologic subtype of non-small-cell lung cancer. J Clin Oncol. 2012;30:4352-9 pubmed publisher
    ..Of the 13 patients, nine patients had KIF5B-RET, three patients had CCDC6-RET, and one patient had a novel NCOA4-RET fusion...
  15. Hout D, Schweitzer B, Lawrence K, Morris S, Tucker T, Mazzola R, et al. Performance of a RT-PCR Assay in Comparison to FISH and Immunohistochemistry for the Detection of ALK in Non-Small Cell Lung Cancer. Cancers (Basel). 2017;9: pubmed publisher
    ..Sequencing of RNA detected full-length ALK transcripts or EML4-ALK and KIF5B-ALK fusion variants in discordant cases in which ALK expression was detected by the ALK RT-PCR test but ..
  16. Chen L, Wang Y, Tseng G. Cortical compression rapidly trimmed transcallosal projections and altered axonal anterograde transport machinery. Neuroscience. 2017;362:79-94 pubmed publisher
    ..b>Kinesin heavy chain (KHC) level in CC was temporarily increased 1week after compression...
  17. Hou H, Yang X, Zhang J, Zhang Z, Xu X, Zhang X, et al. Discovery of targetable genetic alterations in advanced non-small cell lung cancer using a next-generation sequencing-based circulating tumor DNA assay. Sci Rep. 2017;7:14605 pubmed publisher
    ..included 25 EGFR mutations, 5 BRAF mutations, and 1 MET mutation, as well as 1 EML4-ALK gene fusion and 1 KIF5B-RET gene fusion. In 19...
  18. Blakeslee W, Lin Y, Stratton M, Tatman P, Hu T, Ferguson B, et al. Class I HDACs control a JIP1-dependent pathway for kinesin-microtubule binding in cardiomyocytes. J Mol Cell Cardiol. 2017;112:74-82 pubmed publisher
    ..Instead, HDAC inhibitor-mediated induction of JIP1 was required to stimulate expression of the kinesin heavy chain family member, KIF5A...
  19. Bao L. Trafficking regulates the subcellular distribution of voltage-gated sodium channels in primary sensory neurons. Mol Pain. 2015;11:61 pubmed publisher
    ..Axonal transport and localization of Navs in afferent fibers involves the motor protein KIF5B and scaffold proteins, including contactin and PDZ domain containing 2. Localization of Nav1...
  20. Takeuchi K, Soda M, Togashi Y, Suzuki R, Sakata S, Hatano S, et al. RET, ROS1 and ALK fusions in lung cancer. Nat Med. 2012;18:378-81 pubmed publisher
    ..unidentified kinase fusions that may be promising for molecular-targeted therapy, kinesin family member 5B (KIF5B)-ret proto-oncogene (RET) and coiled-coil domain containing 6 (CCDC6)-RET, in 14 adenocarcinomas...
  21. Kato S, Subbiah V, Marchlik E, Elkin S, Carter J, Kurzrock R. RET Aberrations in Diverse Cancers: Next-Generation Sequencing of 4,871 Patients. Clin Cancer Res. 2017;23:1988-1997 pubmed publisher
    ..Two cases with lung (KIF5B-RET) and medullary thyroid carcinoma (RET M918T) that responded to a vandetanib (multikinase RET ..
  22. Wang Q, Yang X, He Y, Ma Q, Lin L, Fu P, et al. Droplet Digital PCR for Absolute Quantification of EML4-ALK Gene Rearrangement in Lung Adenocarcinoma. J Mol Diagn. 2015;17:515-20 pubmed publisher
    ..The case missed by ddPCR was identified as KIF5B-ALK gene rearrangement by PCR-based direct sequencing...
  23. Robert A, Tian P, Adam S, Kittisopikul M, Jaqaman K, Goldman R, et al. Kinesin-dependent transport of keratin filaments: a unified mechanism for intermediate filament transport. FASEB J. 2019;33:388-399 pubmed publisher
    ..Furthermore, we found that the same domain of the kinesin heavy chain tail is involved in keratin and vimentin IF transport, strongly suggesting that multiple types of IFs move ..
  24. Xuan L, Hoat L. Handwashing among schoolchildren in an ethnically diverse population in northern rural Vietnam. Glob Health Action. 2013;6:1-8 pubmed publisher
    ..14 (2.00-8.56), grade 7 vs. grade 1: OR=7.76 (3.67-16.4)] and less common in ethnic minority groups [Xa Phó vs. Kinh-Tay: OR=0.28 (0.11-0.70)]...
  25. Kodama T, Tsukaguchi T, Satoh Y, Yoshida M, Watanabe Y, Kondoh O, et al. Alectinib shows potent antitumor activity against RET-rearranged non-small cell lung cancer. Mol Cancer Ther. 2014;13:2910-8 pubmed publisher
    ..inhibitory activity against RET gatekeeper mutations (RET V804L and V804M) and blocked cell growth driven by the KIF5B-RET V804L and V804M. Our results suggest that alectinib is effective against RET fusion-positive tumors...
  26. Pu J, Keren Kaplan T, Bonifacino J. A Ragulator-BORC interaction controls lysosome positioning in response to amino acid availability. J Cell Biol. 2017;216:4183-4197 pubmed publisher
    ..found to promote lysosome dispersal through coupling to the small GTPase Arl8 and the kinesins KIF1B and KIF5B. Interaction with Ragulator exerts a negative regulatory effect on BORC that is independent of mTORC1 activity...
  27. Nemani N, Carvalho E, Tomar D, Dong Z, Ketschek A, Breves S, et al. MIRO-1 Determines Mitochondrial Shape Transition upon GPCR Activation and Ca2+ Stress. Cell Rep. 2018;23:1005-1019 pubmed publisher
    ..Moreover, Ca2+-dependent disruption of Miro1/KIF5B/tubulin complex is determined by Miro1 EF1 domain...
  28. Nguyen P, Hoang M, Hajeebhoy N, Tran L, Le C, Menon P, et al. Maternal willingness to pay for infant and young child nutrition counseling services in Vietnam. Glob Health Action. 2015;8:28001 pubmed publisher
    ..In multiple regression models, WTP rates were higher among younger women, the Kinh majority group, and better educated and wealthier women...
  29. Rouvière D, Bousquet E, Pons E, Milia J, Guibert N, Mazieres J. [New targets and new drugs in thoracic oncology]. Rev Mal Respir. 2015;32:867-76 pubmed publisher
    ..have been highlighted recently including BRAF mutations, HER2 or PI3K, new translocations such as ROS1 or KIF5B-RET...
  30. Gache V, Gomes E, Cadot B. Microtubule motors involved in nuclear movement during skeletal muscle differentiation. Mol Biol Cell. 2017;28:865-874 pubmed publisher
    ..We further focus on Kif1c, Kif5b, kif9, kif21b, and Kif1a, which affect nuclear alignment...
  31. Mauvezin C, Neisch A, Ayala C, Kim J, Beltrame A, Braden C, et al. Coordination of autophagosome-lysosome fusion and transport by a Klp98A-Rab14 complex in Drosophila. J Cell Sci. 2016;129:971-82 pubmed publisher
    ..In contrast, depletion of the conventional kinesin heavy chain caused a similar mislocalization of autophagosomes without perturbing their fusion with lysosomes, ..
  32. Beschin A, Van den Abbeele J, De Baetselier P, Pays E. African trypanosome control in the insect vector and mammalian host. Trends Parasitol. 2014;30:538-47 pubmed publisher
    ..Tsetse fly saliva and various trypanosome components including adenylate cyclases, DNA, a kinesin heavy chain, and variant surface glycoprotein (VSG) interfere with resistance and tolerance to infection.
  33. Hicks J, Saller J, Wang E, Boyle T, Gray J. Cell-free circulating tumor DNA supplementing tissue biopsies for identification of targetable mutations: Implications for precision medicine and considerations for reconciling results. Lung Cancer. 2017;111:135-138 pubmed publisher describes a patient who was negative for RET rearrangements by tissue interrogation, but positive for a RET-KIF5B fusion by ctDNA NGS. Further tissue analysis demonstrated heterogeneity was the cause of differing results...
  34. Kikuchi K, Nakamura A, Arata M, Shi D, Nakagawa M, Tanaka T, et al. Map7/7D1 and Dvl form a feedback loop that facilitates microtubule remodeling and Wnt5a signaling. EMBO Rep. 2018;19: pubmed publisher
    ..Wnt5a signaling also promotes Map7/7D1 movement toward MT plus-ends, and depletion of the Kinesin-1 member Kif5b abolishes the Map7/7D1 dynamics and Disheveled localization. Furthermore, Disheveled stabilizes Map7/7D1...
  35. Ishida M, Ohbayashi N, Fukuda M. Rab1A regulates anterograde melanosome transport by recruiting kinesin-1 to melanosomes through interaction with SKIP. Sci Rep. 2015;5:8238 pubmed publisher
    ..Rab1A on melanosomes recruits SKIP/PLEKHM2 as a Rab1A-specific effector and that Rab1A, SKIP, and a kinesin-1/(Kif5b+KLC2) motor form a transport complex that mediates anterograde melanosome transport in melanocytes...
  36. Wiszniewski W, Hunter J, Hanchard N, Willer J, Shaw C, Tian Q, et al. TM4SF20 ancestral deletion and susceptibility to a pediatric disorder of early language delay and cerebral white matter hyperintensities. Am J Hum Genet. 2013;93:197-210 pubmed publisher
    ..Finally, we report this deletion to be enriched in individuals of Vietnamese Kinh descent, with an allele frequency of about 1%, embedded in an ancestral haplotype...
  37. Viglianisi C, Amorati R, Di Pietro L, Menichetti S. A Straightforward Route to Potent Phenolic Chain-Breaking Antioxidants by Acid-Promoted Transposition of 1,4-Benzo[b]oxathiines to Dihydrobenzo[b]thiophenes. Chemistry. 2015;21:16639-45 pubmed publisher
    ..with a sulfide sulfur ortho to the phenolic OH, have a rate constant of reaction with alkylperoxyl radicals (kinh ) comparable to that of α-tocopherol...
  38. Pham H, Constant J. A new species of the cicada genus Semia Matsumura, 1917 (Hemiptera: Cicadidae) from Vietnam, with a key to the species of the genus. Zootaxa. 2013;3709:494-500 pubmed
    A new species of cicada, Semia gialaiensis, is described from Kon Ka Kinh National Park in central Vietnam. Photos of the adult, illustrations of the male genitalia, a distribution map and biological data are provided...
  39. Chuong N, Van Minh H, Thi Thuy Duong D, Duc D, Anh Dao L, Duy Anh N. Progress on maternal health care in Vietnam: Findings from Vietnam Multiple Indicator Cluster Survey 2000, 2006, 2011, and 2014. Health Care Women Int. 2017;:1-9 pubmed publisher
    ..with the assistance of a skilled health personnel were much higher among those with higher education, belonged to Kinh majority tribe, had better economic status, and lived in an urban area...
  40. Diefenbach R, Diefenbach E, Douglas M, Cunningham A. The ribosome receptor, p180, interacts with kinesin heavy chain, KIF5B. Biochem Biophys Res Commun. 2004;319:987-92 pubmed
    ..In this study we employed a yeast two-hybrid assay to identify additional binding partners of the kinesin heavy chain isoform KIF5B...
  41. Nguyen T, Nguyen P, Hajeebhoy N, Nguyen H, Frongillo E. Infant and young child feeding practices differ by ethnicity of Vietnamese mothers. BMC Pregnancy Childbirth. 2016;16:214 pubmed publisher
    ..We used data on 1875 women who came from the ethnic majority, Kinh (n?=?989, randomly sampled from 9875 surveyed Kinh mothers, 10 % from each province) and three ethnic minorities: ..
  42. Li J, Fu X, Cao S, Li J, Xing S, Li D, et al. Membrane-associated androgen receptor (AR) potentiates its transcriptional activities by activating heat shock protein 27 (HSP27). J Biol Chem. 2018;293:12719-12729 pubmed publisher
    ..Disruption of the function of kinesin 5B (KIF5B), but not of kinesin C3 (KIFC3), interfered with AR membrane association and signaling...
  43. Wong Y, Dietrich K, Naber N, Cooke R, Rice S. The Kinesin-1 tail conformationally restricts the nucleotide pocket. Biophys J. 2009;96:2799-807 pubmed publisher
  44. Wang Q, Feng H, Zheng P, Shen B, Chen L, Liu L, et al. The intracellular transport and secretion of calumenin-1/2 in living cells. PLoS ONE. 2012;7:e35344 pubmed publisher
    ..required microtubule integrity, and that calu-1/2-EGFP-containing vesicles were transported by the motor proteins Kif5b and cytoplasmic dynein...
  45. Munoz I, Danelli L, Claver J, Goudin N, Kurowska M, Madera Salcedo I, et al. Kinesin-1 controls mast cell degranulation and anaphylaxis through PI3K-dependent recruitment to the granular Slp3/Rab27b complex. J Cell Biol. 2016;215:203-216 pubmed
    ..In this study, we demonstrate that mice lacking Kif5b (the heavy chain of kinesin-1) in hematopoietic cells are less sensitive to IgE-mediated, passive, systemic ..
  46. Kim J, Shin J, Kim M, Son K, Jung C, Kim T, et al. Detection of RET (rearranged during transfection) variants and their downstream signal molecules in RET rearranged lung adenocarcinoma patients. Surg Oncol. 2018;27:106-113 pubmed publisher
    ..rearranged during transfection (RET) gene variants (including RET rearrangements and the Kinesin Family Member 5B (KIF5B)-RET fusion gene) using various methods including reverse transcription polymerase chain reaction (RT-PCR), ..
  47. Velizheva N, Rechsteiner M, Valtcheva N, Freiberger S, Wong C, Vrugt B, et al. Targeted next-generation-sequencing for reliable detection of targetable rearrangements in lung adenocarcinoma-a single center retrospective study. Pathol Res Pract. 2018;214:572-578 pubmed publisher
    ..Besides EML4-ALK (11/52 cases), we detected EZR-ROS1 (1/52 cases), KIF5B-RET (1/52 cases) and MET-MET (4/52 cases) fusions...
  48. Melkov A, Simchoni Y, Alcalay Y, Abdu U. Dynamic microtubule organization and mitochondrial transport are regulated by distinct Kinesin-1 pathways. Biol Open. 2015;4:1696-706 pubmed publisher
    The microtubule (MT) plus-end motor kinesin heavy chain (Khc) is well known for its role in long distance cargo transport...
  49. Drilon A, Rekhtman N, Arcila M, Wang L, Ni A, Albano M, et al. Cabozantinib in patients with advanced RET-rearranged non-small-cell lung cancer: an open-label, single-centre, phase 2, single-arm trial. Lancet Oncol. 2016;17:1653-1660 pubmed publisher
    ..b>KIF5B-RET was the predominant fusion type identified in 16 (62%) patients...
  50. Sarfaty M, Moore A, Neiman V, Dudnik E, Ilouze M, Gottfried M, et al. RET Fusion Lung Carcinoma: Response to Therapy and Clinical Features in a Case Series of 14 Patients. Clin Lung Cancer. 2017;18:e223-e232 pubmed publisher
    ..In contrast, KIF5B-RET and CCDC6-RET fusion genes have been identified in 70% to 90% and 10% to 25% of tumors, respectively...
  51. Ichimura T, Wakamiya Tsuruta A, Itagaki C, Taoka M, Hayano T, Natsume T, et al. Phosphorylation-dependent interaction of kinesin light chain 2 and the 14-3-3 protein. Biochemistry. 2002;41:5566-72 pubmed
    ..Among them are several proteins in the membrane traffic pathway, such as the heavy and light chains (KHC/KIF5B and KLC2) of conventional kinesin, a heterotetrameric mechanochemical motor involved in the ATP-dependent movement ..
  52. Goes F, Hamshere M, Seifuddin F, Pirooznia M, Belmonte Mahon P, Breuer R, et al. Genome-wide association of mood-incongruent psychotic bipolar disorder. Transl Psychiatry. 2012;2:e180 pubmed publisher
    ..The results of our polygenic analysis provides support for a modest degree of genetic overlap between BP with MICP and SZ, highlighting that phenotypic correlations across syndromes may be due to the influence of polygenic risk factors. ..
  53. Li M, Zheng W. Probing the structural and energetic basis of kinesin-microtubule binding using computational alanine-scanning mutagenesis. Biochemistry. 2011;50:8645-55 pubmed publisher
    ..The mutations of these residues are predicted to fine-tune the motility of kinesin by modulating the conformational transition between the ADP state and the ATP state of kinesin. ..
  54. López E, Casasnovas C, Giménez J, Santamaría R, Terrazas J, Volpini V. Identification of two novel KIF5A mutations in hereditary spastic paraplegia associated with mild peripheral neuropathy. J Neurol Sci. 2015;358:422-7 pubmed publisher
    ..This study adds to the evidence associating the known occurrence of mild peripheral neuropathy in the adult onset SPG10 type of AD-HSP. ..
  55. Lee C. Identification of Kinesin-1 Cargos Using Fluorescence Microscopy. J Vis Exp. 2016;:53632 pubmed publisher
    Fluorescence microscopy is employed to identify Kinesin-1 cargos. Recently, the heavy chain of Kinesin-1 (KIF5B) was shown to transport the nuclear transcription factor c-MYC for proteosomal degradation in the cytoplasm...
  56. Amorati R, Baschieri A, Morroni G, Gambino R, Valgimigli L. Peroxyl Radical Reactions in Water Solution: A Gym for Proton-Coupled Electron-Transfer Theories. Chemistry. 2016;22:7924-34 pubmed publisher
    ..With this method we measured the rate constants kinh for the reactions of 2-tetrahydrofuranylperoxyl radicals with reference compounds: urate, ascorbate, ferrocenes, 2,..
  57. Adam F, Kauskot A, Kurowska M, Goudin N, Munoz I, Bordet J, et al. Kinesin-1 Is a New Actor Involved in Platelet Secretion and Thrombus Stability. Arterioscler Thromb Vasc Biol. 2018;38:1037-1051 pubmed publisher
    ..By studying a mouse model (cKO [conditional knockout]Kif5b) lacking Kif5b (kinesin-1 heavy chain) in its megakaryocytes and platelets, we evidenced unstable hemostasis ..
  58. Roux K, Crisp M, Liu Q, Kim D, Kozlov S, Stewart C, et al. Nesprin 4 is an outer nuclear membrane protein that can induce kinesin-mediated cell polarization. Proc Natl Acad Sci U S A. 2009;106:2194-9 pubmed publisher
    ..These effects can be accounted for entirely by Nesp4's kinesin-binding function. The implication is that Nesp4 may contribute to microtubule-dependent nuclear positioning. ..
  59. CYRUS B, Muller W. A Unique Role for Endothelial Cell Kinesin Light Chain 1, Variant 1 in Leukocyte Transendothelial Migration. Am J Pathol. 2016;186:1375-86 pubmed publisher
    ..In complementary experiments, knocking down KIF5B, a ubiquitous kinesin-1 isoform, in endothelial cells significantly decreased targeted recycling of the LBRC and ..
  60. Guardia C, Farías G, Jia R, Pu J, Bonifacino J. BORC Functions Upstream of Kinesins 1 and 3 to Coordinate Regional Movement of Lysosomes along Different Microtubule Tracks. Cell Rep. 2016;17:1950-1961 pubmed publisher
    ..Here, we show that BORC and Arl8 function upstream of two structurally distinct kinesin types: kinesin-1 (KIF5B) and kinesin-3 (KIF1Bβ and KIF1A)...
  61. Kawano Y, Yoshimura T, Tsuboi D, Kawabata S, Kaneko Kawano T, Shirataki H, et al. CRMP-2 is involved in kinesin-1-dependent transport of the Sra-1/WAVE1 complex and axon formation. Mol Cell Biol. 2005;25:9920-35 pubmed
    ..These results suggest that CRMP-2 transports the Sra-1/WAVE1 complex to axons in a kinesin-1-dependent manner and thereby regulates axon outgrowth and formation. ..
  62. Cho K, Yi H, Desai R, Hand A, Haas A, Ferreira P. RANBP2 is an allosteric activator of the conventional kinesin-1 motor protein, KIF5B, in a minimal cell-free system. EMBO Rep. 2009;10:480-6 pubmed publisher
    ..The RAN-binding protein 2 (RANBP2), through its kinesin-binding domain (KBD), associates in vivo with kinesin-1, KIF5B/KIF5C...
  63. MacDonald J, Dietrich A, Gamble S, Hryciw T, Grant R, Meakin S. Nesca, a novel neuronal adapter protein, links the molecular motor kinesin with the pre-synaptic membrane protein, syntaxin-1, in hippocampal neurons. J Neurochem. 2012;121:861-80 pubmed publisher
    ..Nesca co-immunoprecipitates with kinesin heavy chain (KIF5B) and kinesin light-chain motors as well as with the synaptic membrane precursor protein, syntaxin-1, ..
  64. McCoach C, Blakely C, Banks K, Levy B, Chue B, Raymond V, et al. Clinical Utility of Cell-Free DNA for the Detection of ALK Fusions and Genomic Mechanisms of ALK Inhibitor Resistance in Non-Small Cell Lung Cancer. Clin Cancer Res. 2018;24:2758-2770 pubmed publisher
    ..b>Results: Identified fusion partners included EML4 (85.4%), STRN (6%), and KCNQ, KLC1, KIF5B, PPM1B, and TGF (totaling 8.3%)...
  65. Rahman A, Kamal A, Roberts E, Goldstein L. Defective kinesin heavy chain behavior in mouse kinesin light chain mutants. J Cell Biol. 1999;146:1277-88 pubmed
    Conventional kinesin, kinesin-I, is a heterotetramer of two kinesin heavy chain (KHC) subunits (KIF5A, KIF5B, or KIF5C) and two kinesin light chain (KLC) subunits. While KHC contains the motor activity, the role of KLC remains unknown...
  66. Gupta V, Palmer K, Spence P, Hudson A, Stephens D. Kinesin-1 (uKHC/KIF5B) is required for bidirectional motility of ER exit sites and efficient ER-to-Golgi transport. Traffic. 2008;9:1850-66 pubmed publisher
    ..Bidirectionality depends on both kinesin-1 and dynein. Suppression of kinesin-1 (KIF5B) also inhibits ER-to-Golgi transport and affects the morphology of ER-to-Golgi transport carriers...
  67. She Z, Yang W. Molecular mechanisms of kinesin-14 motors in spindle assembly and chromosome segregation. J Cell Sci. 2017;130:2097-2110 pubmed publisher
  68. Hakimi M, Speicher D, Shiekhattar R. The motor protein kinesin-1 links neurofibromin and merlin in a common cellular pathway of neurofibromatosis. J Biol Chem. 2002;277:36909-12 pubmed
    ..core-NF1 complex followed by mass spectrometric analysis revealed the motor protein, kinesin-1 heavy chain (HsuKHC/KIF5B), as a catalytic subunit of both NF-1-containing complexes...
  69. Trejo H, Lecuona E, Grillo D, Szleifer I, Nekrasova O, Gelfand V, et al. Role of kinesin light chain-2 of kinesin-1 in the traffic of Na,K-ATPase-containing vesicles in alveolar epithelial cells. FASEB J. 2010;24:374-82 pubmed publisher
    ..Thus, a specific isoform of kinesin-1 is required for microtubule-dependent recruitment of Na,K-ATPase to the plasma membrane, which is of physiological significance. ..
  70. Dodding M, Mitter R, Humphries A, Way M. A kinesin-1 binding motif in vaccinia virus that is widespread throughout the human genome. EMBO J. 2011;30:4523-38 pubmed publisher
    ..Our observations demonstrate that KLC binding can be conferred by a common set of features that are found in a wide range of proteins associated with diverse cellular functions and human diseases...
  71. Lee C. Transport of c-MYC by Kinesin-1 for proteasomal degradation in the cytoplasm. Biochim Biophys Acta. 2014;1843:2027-36 pubmed publisher
    ..Transport studies showed that the c-MYC aggregates moved from the nucleus to the cytoplasm and KIF5B is responsible for the transport in the cytoplasm...
  72. Veeranan Karmegam R, Boggupalli D, Liu G, Gonsalvez G. A new isoform of Drosophila non-muscle Tropomyosin 1 interacts with Kinesin-1 and functions in oskar mRNA localization. J Cell Sci. 2016;129:4252-4264 pubmed
    ..Unlike most Kinesin-1 cargoes, localization of osk mRNA requires the Kinesin heavy chain (Khc) motor subunit, but not the Kinesin light chain (Klc) adaptor...
  73. Wang Z, Zhang F, He J, Wu P, Tay L, Cai M, et al. Binding of PLD2-Generated Phosphatidic Acid to KIF5B Promotes MT1-MMP Surface Trafficking and Lung Metastasis of Mouse Breast Cancer Cells. Dev Cell. 2017;43:186-197.e7 pubmed publisher
    ..A liposome pull-down screen identifies KIF5B, the heavy chain of the motor protein kinesin-1, as a new PA-binding protein...
  74. Diefenbach R, Diefenbach E, Douglas M, Cunningham A. The heavy chain of conventional kinesin interacts with the SNARE proteins SNAP25 and SNAP23. Biochemistry. 2002;41:14906-15 pubmed
    ..A human brain cDNA library was screened, using as bait residues 814-963 of human ubiquitous kinesin heavy chain. This screen initially identified synaptosome-associated protein of 25 kDa (SNAP25) as a kinesin-..
  75. Cai Q, Gerwin C, Sheng Z. Syntabulin-mediated anterograde transport of mitochondria along neuronal processes. J Cell Biol. 2005;170:959-69 pubmed
  76. Mori T, Vale R, Tomishige M. How kinesin waits between steps. Nature. 2007;450:750-4 pubmed
    ..On the basis of these results, we suggest a model for how transitions in the ATPase cycle position the two kinesin heads and drive their hand-over-hand motion. ..
  77. Cardoso C, Groth Pedersen L, Høyer Hansen M, Kirkegaard T, Corcelle E, Andersen J, et al. Depletion of kinesin 5B affects lysosomal distribution and stability and induces peri-nuclear accumulation of autophagosomes in cancer cells. PLoS ONE. 2009;4:e4424 pubmed publisher
    ..Mass spectrometry analysis identified kinesin heavy chain protein KIF5B as the only microtubule motor associated with the lysosomes in MCF-7 cells, and ectopic ..
  78. Milewska M, McRedmond J, Byrne P. Identification of novel spartin-interactors shows spartin is a multifunctional protein. J Neurochem. 2009;111:1022-30 pubmed publisher
    ..We also show for the first time interaction between spartin and a nucleolar protein, nucleolin. ..
  79. Lukic Z, Dharan A, Fricke T, Diaz Griffero F, Campbell E. HIV-1 uncoating is facilitated by dynein and kinesin 1. J Virol. 2014;88:13613-25 pubmed publisher
    ..that pharmacological or small interfering RNA (siRNA)-mediated inhibition of cytoplasmic dynein or the kinesin 1 heavy chain KIF5B delays uncoating, providing detailed insight into how microtubules facilitate the uncoating process...
  80. Wilson M, Holzbaur E. Nesprins anchor kinesin-1 motors to the nucleus to drive nuclear distribution in muscle cells. Development. 2015;142:218-28 pubmed publisher
    ..Here, we test the hypothesis that an ensemble of Kif5B motors acts from the nuclear envelope to distribute nuclei throughout the length of syncytial myotubes...
  81. Viola D, Giani C, Mazzeo S, Ugolini C, Ciampi R, Molinaro E, et al. KIF5B/RET Rearrangement in a Carcinoma of the Thyroid Gland: A Case Report of a Fatal Disease. J Clin Endocrinol Metab. 2017;102:3091-3096 pubmed publisher
    ..revision of the thyroid tumor confirmed the diagnosis of DSV-PTC, and its molecular analysis revealed a KIF5B/RET rearrangement that, until now, was described only in a minority of lung adenocarcinoma...
  82. Arai S, Kita K, Tanimoto A, Takeuchi S, Fukuda K, Sato H, et al. In vitro and in vivo anti-tumor activity of alectinib in tumor cells with NCOA4-RET. Oncotarget. 2017;8:73766-73773 pubmed publisher
    ..To date, RET fusions that involve at least six fusion partners in NSCLC, such as KIF5B, CCDC6, NCOA4, TRIM33, CLIP1, and ERC1, have been identified...
  83. Tomishige M, Stuurman N, Vale R. Single-molecule observations of neck linker conformational changes in the kinesin motor protein. Nat Struct Mol Biol. 2006;13:887-94 pubmed
    ..During ATP-driven motility, the neck linkers switch between these conformational states. These results support the notion that neck linker movements accompany the 'hand-over-hand' motion of the two motor domains. ..
  84. Dietrich K, Sindelar C, Brewer P, Downing K, Cremo C, Rice S. The kinesin-1 motor protein is regulated by a direct interaction of its head and tail. Proc Natl Acad Sci U S A. 2008;105:8938-43 pubmed publisher
    ..The interaction of the Switch I region of the kinesin-1 head with the tail is strikingly similar to the interactions of small GTPases with their regulators, indicating that other kinesin motors may share similar regulatory mechanisms. ..
  85. Seeger M, Rice S. Microtubule-associated protein-like binding of the kinesin-1 tail to microtubules. J Biol Chem. 2010;285:8155-62 pubmed publisher
  86. Rosa Ferreira C, Munro S. Arl8 and SKIP act together to link lysosomes to kinesin-1. Dev Cell. 2011;21:1171-8 pubmed publisher
    ..A splice variant of SKIP that lacks a light chain binding motif does not stimulate movement, suggesting fine-tuning by alternative splicing. ..
  87. Cochran J, Zhao Y, Wilcox D, Kull F. A metal switch for controlling the activity of molecular motor proteins. Nat Struct Mol Biol. 2011;19:122-7 pubmed publisher
    ..In human kinesin-1 and kinesin-5 as well as Drosophila melanogaster kinesin-10 and kinesin-14, this defect is rescued by Mn(2+), providing a way to control both the enzymatic activity and force-generating ability of these nanomachines. ..
  88. Pauli E, Chan Y, Davis M, Gableske S, Wang M, Feister K, et al. The ubiquitin-specific protease USP15 promotes RIG-I-mediated antiviral signaling by deubiquitylating TRIM25. Sci Signal. 2014;7:ra3 pubmed publisher
    ..Together, these data identify USP15 as a critical regulator of the TRIM25- and RIG-I-mediated antiviral immune response, thereby highlighting the intricate regulation of innate immune signaling. ..
  89. Du W, Su Q, Chen Y, Zhu Y, Jiang D, Rong Y, et al. Kinesin 1 Drives Autolysosome Tubulation. Dev Cell. 2016;37:326-336 pubmed publisher
    ..using an approach combining in vivo studies and in vitro reconstitution, we found that the kinesin motor protein KIF5B is required for autolysosome tubulation and that KIF5B drives autolysosome tubulation by pulling on the ..
  90. Sanger A, Yip Y, Randall T, Pernigo S, Steiner R, Dodding M. SKIP controls lysosome positioning using a composite kinesin-1 heavy and light chain-binding domain. J Cell Sci. 2017;130:1637-1651 pubmed publisher
    ..Thus, cargo recognition and concurrent activation of kinesin-1 proceed in hierarchical stepwise fashion driven by a dynamic network of inter- and intra-molecular interactions. ..
  91. Liu Y, Wang L, Zhang T, Yang X, Li D. Functional characterization of KS-type dehydrin ZmDHN13 and its related conserved domains under oxidative stress. Sci Rep. 2017;7:7361 pubmed publisher
    ..and order of the Y-, S- and K-segments, dehydrins are classified into five subclasses: YnSKn, YnKn, SKn, Kn and KnS. Here, the maize (Zea mays L.) KS-type dehydrin gene, ZmDHN13, was identified and later characterized...
  92. Zadeh A, Cheng Y, Xu H, Wong N, Wang Z, Goonasekara C, et al. Kif5b is an essential forward trafficking motor for the Kv1.5 cardiac potassium channel. J Physiol. 2009;587:4565-74 pubmed publisher
    We have investigated the role of the kinesin I isoform Kif5b in the trafficking of a cardiac voltage-gated potassium channel, Kv1.5. In Kv1...