KIF3A

Summary

Gene Symbol: KIF3A
Description: kinesin family member 3A
Alias: FLA10, KLP-20, kinesin-like protein KIF3A, kinesin family protein 3A, microtubule plus end-directed kinesin motor 3A
Species: human
Products:     KIF3A

Top Publications

  1. Yamazaki H, Nakata T, Okada Y, Hirokawa N. KIF3A/B: a heterodimeric kinesin superfamily protein that works as a microtubule plus end-directed motor for membrane organelle transport. J Cell Biol. 1995;130:1387-99 pubmed
    ..brain kinesin superfamily, KIF3B, and found that its amino acid sequence is highly homologous but not identical to KIF3A, which we previously cloned and named KIF3 (47% identical)...
  2. Hasegawa T, Yagi A, Isobe K. Interaction between GADD34 and kinesin superfamily, KIF3A. Biochem Biophys Res Commun. 2000;267:593-6 pubmed
    ..One cDNA clone was the C-terminal part of KIF3A gene including the tail domain...
  3. Zhang Y, Hancock W. The two motor domains of KIF3A/B coordinate for processive motility and move at different speeds. Biophys J. 2004;87:1795-804 pubmed
    b>KIF3A/B, a kinesin involved in intraflagellar transport and Golgi trafficking, is distinctive because it contains two nonidentical motor domains...
  4. Brown C, Maier K, Stauber T, Ginkel L, Wordeman L, Vernos I, et al. Kinesin-2 is a motor for late endosomes and lysosomes. Traffic. 2005;6:1114-24 pubmed
    ..might also power endosome movement in non-pigmented cells, we overexpressed dominant negative forms of the KIF3A motor subunit and KAP3 accessory subunit and knocked down KAP3 levels using RNAi...
  5. Kim J, Cha J, Cheong H, Park J, Jang A, Uh S, et al. KIF3A, a cilia structural gene on chromosome 5q31, and its polymorphisms show an association with aspirin hypersensitivity in asthma. J Clin Immunol. 2011;31:112-21 pubmed publisher
    The kinesin family number 3A (KIF3A) gene on the human chromosomal 5q31-33 region, which is known as a susceptibility locus for immune diseases including asthma, plays a crucial role in generation of cilia...
  6. Ho Wei L, Arastoo M, Georgiou I, Manning D, Riobo Del Galdo N. Activation of the Gi protein-RHOA axis by non-canonical Hedgehog signaling is independent of primary cilia. PLoS ONE. 2018;13:e0203170 pubmed publisher
    ..RHOA and Gi protein stimulation by activation of SMO or sphingosine 1-phosphate receptor (S1P) receptors in WT and KIF3A-deficient mouse embryonic fibroblasts that lack primary cilia...
  7. Kluth O, Stadion M, Gottmann P, Aga H, Jähnert M, Scherneck S, et al. Decreased Expression of Cilia Genes in Pancreatic Islets as a Risk Factor for Type 2 Diabetes in Mice and Humans. Cell Rep. 2019;26:3027-3036.e3 pubmed publisher
    ..The shRNA-mediated suppression of KIF3A, essential for ciliogenesis, impairs division of MIN6 beta cells as well as in dispersed primary mouse and human ..
  8. Engelke M, Waas B, Kearns S, Suber A, Boss A, Allen B, et al. Acute Inhibition of Heterotrimeric Kinesin-2 Function Reveals Mechanisms of Intraflagellar Transport in Mammalian Cilia. Curr Biol. 2019;: pubmed publisher
    ..Loss of function in any subunit of the heterotrimeric KIF3A/KIF3B/KAP kinesin-2 motor prevents ciliogenesis in mammalian cells and has hindered an understanding of how ..
  9. Schimert K, Budaitis B, Reinemann D, Lang M, Verhey K. Intracellular cargo transport by single-headed kinesin motors. Proc Natl Acad Sci U S A. 2019;116:6152-6161 pubmed publisher
    ..Strikingly, monomeric versions of the kinesin-2 family motors KIF3A and KIF3B are able to drive Golgi dispersion in cells, and teams of monomeric KIF3B motors can generate over 8 pN ..

More Information

Publications108 found, 100 shown here

  1. Bananis E, Nath S, Gordon K, Satir P, Stockert R, Murray J, et al. Microtubule-dependent movement of late endocytic vesicles in vitro: requirements for Dynein and Kinesin. Mol Biol Cell. 2004;15:3688-97 pubmed
    ..reduced association with receptor, Rab4, and kinesin I but were highly associated with dynein, Rab7, dynactin, and KIF3A. Dynein and KIF3A antibodies inhibited late vesicle motility, whereas kinesin I and KIFC2 antibodies had no effect...
  2. Khonsari R, Seppala M, Pradel A, Dutel H, Clément G, Lebedev O, et al. The buccohypophyseal canal is an ancestral vertebrate trait maintained by modulation in sonic hedgehog signaling. BMC Biol. 2013;11:27 pubmed publisher
    ..Polaris(fl/fl); Wnt1-Cre, Ofd1(-/-) and Kif3a(-/-) primary cilia mouse mutants have abnormal sonic hedgehog (Shh) signaling and all present with malformations ..
  3. Hsiao C, Chang C, Ibrahim R, Lin I, Wang C, Wang W, et al. Gli2 modulates cell cycle re-entry through autophagy-mediated regulation of the length of primary cilia. J Cell Sci. 2018;131: pubmed publisher
    ..Ablation of their primary cilia through Kif3a knockdown rescues the delay in cell cycle re-entry...
  4. Lin Y, Jones B, Liu A, Vazquéz Chona F, Lauritzen J, Ferrell W, et al. Rapid glutamate receptor 2 trafficking during retinal degeneration. Mol Neurodegener. 2012;7:7 pubmed publisher
    ..Immunoprecipitation analysis showed interaction between KIF3A and GRIP1 as well as PSD-95, suggesting that KIF3A may mediate transport of GluR2 and its trafficking proteins to ..
  5. Cui J, Li X, Duan Z, Xue W, Wang Z, Lu S, et al. Analysis of Kif5b expression during mouse kidney development. PLoS ONE. 2015;10:e0126002 pubmed publisher
    Recent studies showed that kidney-specific inactivation of Kif3a produces kidney cysts and renal failure, suggesting that kinesin-mediated intracellular transportation is important for the establishement and maintenance of renal ..
  6. Ichinose S, Ogawa T, Hirokawa N. Mechanism of Activity-Dependent Cargo Loading via the Phosphorylation of KIF3A by PKA and CaMKIIa. Neuron. 2015;87:1022-35 pubmed publisher
    ..To elucidate this mechanism, we investigated the activity-dependent transport of N-cadherin via its transporter, KIF3A. First, by comparing KIF3A-bound cargo vesicles with unbound KIF3A, we identified critical KIF3A phosphorylation ..
  7. Raghupathy R, Zhang X, Alhasani R, Zhou X, Mullin M, Reilly J, et al. Abnormal photoreceptor outer segment development and early retinal degeneration in kif3a mutant zebrafish. Cell Biochem Funct. 2016;34:429-40 pubmed publisher
    ..Here, we describe a new zebrafish model carrying a nonsense mutation in the kinesin II family member 3A (kif3a) gene. Kif3a mutant zebrafish exhibited curved body axes and kidney cysts...
  8. Massinen S, Hokkanen M, Matsson H, Tammimies K, Tapia Páez I, Dahlström Heuser V, et al. Increased expression of the dyslexia candidate gene DCDC2 affects length and signaling of primary cilia in neurons. PLoS ONE. 2011;6:e20580 pubmed publisher
    ..primary rat hippocampal neurons and that it can be found within close proximity to the ciliary kinesin-2 subunit Kif3a. Overexpression of DCDC2 increases ciliary length and activates Shh signaling, whereas downregulation of Dcdc2 ..
  9. Nag S, Rani S, Mahanty S, Bissig C, Arora P, Azevedo C, et al. Rab4A organizes endosomal domains for sorting cargo to lysosome-related organelles. J Cell Sci. 2018;131: pubmed publisher
    ..Consistent with this, inactivation of rabenosyn-5, KIF3A or KIF3B phenocopied the defects observed in Rab4A-knockdown melanocytes...
  10. Tong C, Han Y, Shah J, Obernier K, Guinto C, Alvarez Buylla A. Primary cilia are required in a unique subpopulation of neural progenitors. Proc Natl Acad Sci U S A. 2014;111:12438-43 pubmed publisher
    ..cilia using conditional alleles for genes essential for intraflagellar transport [kinesin family member 3A (Kif3a) and intraflagellar transport 88 (Ift88)] and Cre drivers that are activated at early [Nestin; embryonic day 10...
  11. Xu Q, Liu W, Liu X, Liu W, Wang H, Yao G, et al. Silibinin negatively contributes to primary cilia length via autophagy regulated by histone deacetylase 6 in confluent mouse embryo fibroblast 3T3-L1 cells. Mol Cell Biochem. 2016;420:53-63 pubmed publisher
    ..Autophagy induced by silibinin decreased expressions of the cilia-associated proteins, such as IFT88, KIF3a and Ac-tubulin, while 3-MA restored it, indicating that autophagy induced by silibinin led to a reduction of ..
  12. Liu X, Kadakkuzha B, Pascal B, Steckler C, Akhmedov K, Yan L, et al. New approach to capture and characterize synaptic proteome. Proc Natl Acad Sci U S A. 2014;111:16154-9 pubmed publisher
    ..used this approach to identify and compare proteins transported to synapses by kinesin (Kif) complexes Kif5C and Kif3A in the mouse hippocampus and prefrontal cortex...
  13. Martin L, He H, Collins M, Abonia J, Biagini Myers J, Eby M, et al. Eosinophilic esophagitis (EoE) genetic susceptibility is mediated by synergistic interactions between EoE-specific and general atopic disease loci. J Allergy Clin Immunol. 2018;141:1690-1698 pubmed publisher
    ..patients with EoE and nonatopic control subjects, EoE associated strongly with IL-4/kinesin family member 3A (IL4/KIF3A) (P = 2.8 × 10-6; odds ratio [OR], 1.87), moderately with TSLP (P = 1...
  14. Albracht C, Rank K, Obrzut S, Rayment I, Gilbert S. Kinesin-2 KIF3AB exhibits novel ATPase characteristics. J Biol Chem. 2014;289:27836-48 pubmed publisher
    ..To define the ATPase mechanism and coordination of KIF3A and KIF3B stepping, a presteady-state kinetic analysis was pursued...
  15. Boehlke C, Janusch H, Hamann C, Powelske C, Mergen M, Herbst H, et al. A Cilia Independent Role of Ift88/Polaris during Cell Migration. PLoS ONE. 2015;10:e0140378 pubmed publisher
    ..Similarly, another essential ciliary molecule, the kinesin-2 subunit Kif3a, which transports Ift-B in the cilium, affects microtubule (MT) dynamics at the leading edge of migrating cells ..
  16. Ginkel L, Wordeman L. Expression and partial characterization of kinesin-related proteins in differentiating and adult skeletal muscle. Mol Biol Cell. 2000;11:4143-58 pubmed
    Using pan-kinesin antibodies to screen a differentiating C2C12 cell library, we identified the kinesin proteins KIF3A, KIF3B, and conventional kinesin heavy chain to be present in differentiating skeletal muscle...
  17. Chen G, Arginteanu D, Hancock W. Processivity of the kinesin-2 KIF3A results from rear head gating and not front head gating. J Biol Chem. 2015;290:10274-94 pubmed publisher
    The kinesin-2 family motor KIF3A/B works together with dynein to bidirectionally transport intraflagellar particles, melanosomes, and neuronal vesicles...
  18. Andreasson J, Shastry S, Hancock W, Block S. The Mechanochemical Cycle of Mammalian Kinesin-2 KIF3A/B under Load. Curr Biol. 2015;25:1166-75 pubmed publisher
    ..The mammalian kinesin-2, KIF3A/B, is a heterotrimeric motor involved in intraflagellar transport and vesicle motility in neurons...
  19. Quinn S, Howsmon D, Hahn J, Gilbert S. Kinesin-2 heterodimerization alters entry into a processive run along the microtubule but not stepping within the run. J Biol Chem. 2018;293:13389-13400 pubmed publisher
    ..1 μm-1 s-1 These results led us to hypothesize that heterodimerization of KIF3A with KIF3C and KIF3A with KIF3B altered the intrinsic catalytic properties of each motor domain...
  20. Lehmann H, Vicari D, Wild P, Frew I. Combined Deletion of Vhl and Kif3a Accelerates Renal Cyst Formation. J Am Soc Nephrol. 2015;26:2778-88 pubmed publisher
    ..deletion of Vhl together with ablation of the primary cilium via deletion of the kinesin family member 3A (Kif3a) gene...
  21. Jiang L, Wei Y, Ronquillo C, Marc R, Yoder B, Frederick J, et al. Heterotrimeric kinesin-2 (KIF3) mediates transition zone and axoneme formation of mouse photoreceptors. J Biol Chem. 2015;290:12765-78 pubmed publisher
    ..We generated embryonic retina-specific (prefix "emb") and adult tamoxifen-induced (prefix "tam") deletions of KIF3a and IFT88 in adult mice to study photoreceptor ciliogenesis and protein trafficking...
  22. Ticianelli J, Emanuelli I, Satrapa R, Castilho A, Loureiro B, Sudano M, et al. Gene expression profile in heat-shocked Holstein and Nelore oocytes and cumulus cells. Reprod Fertil Dev. 2017;29:1787-1802 pubmed publisher
    ..The molecular motor kinesin family member 3A (KIF3A) was upregulated in Holstein oocytes, whereas the pro-apoptotic gene death-associated protein (DAP) and the ..
  23. Johnson S, Spollen W, Manshack L, Bivens N, Givan S, Rosenfeld C. Hypothalamic transcriptomic alterations in male and female California mice (Peromyscus californicus) developmentally exposed to bisphenol A or ethinyl estradiol. Physiol Rep. 2017;5: pubmed publisher
    ..was downregulated in the hypothalamus of BPA- and EE-exposed females, whereas Tbl2, Topors, Kif3a, and Phactr2 were upregulated in these groups...
  24. Ernandez T, Komarynets O, Chassot A, Sougoumarin S, Soulie P, Wang Y, et al. Primary cilia control the maturation of tubular lumen in renal collecting duct epithelium. Am J Physiol Cell Physiol. 2017;313:C94-C107 pubmed publisher
    ..Tubulogenesis and branching were not altered when cilium body growth was inhibited by Kif3A or Ift88 silencing...
  25. Millington G, Elliott K, Chang Y, Chang C, Dlugosz A, Brugmann S. Cilia-dependent GLI processing in neural crest cells is required for tongue development. Dev Biol. 2017;424:124-137 pubmed publisher
    ..Herein, we explored how the conditional loss of primary cilia on neural crest cells (Kif3af/f;Wnt1-Cre) generated aglossia...
  26. Zhang X, Ding H, Xu T, Liu M, Ma C, Wu S, et al. Palmitoylation of δ-catenin promotes kinesin-mediated membrane trafficking of Nav1.6 in sensory neurons to promote neuropathic pain. Sci Signal. 2018;11: pubmed publisher
    ..6 and the kinesin motor protein KIF3A, which promoted the trafficking of Nav1...
  27. Terauchi A, Timmons K, Kikuma K, Pechmann Y, Kneussel M, Umemori H. Selective synaptic targeting of the excitatory and inhibitory presynaptic organizers FGF22 and FGF7. J Cell Sci. 2015;128:281-92 pubmed publisher
    ..Excitatory synaptic targeting of FGF22 requires the motor proteins KIF3A and KIF17 and the adaptor protein SAP102 (also known as DLG3)...
  28. Chen J, Hoey D, Chua M, Bellon R, Jacobs C. Mechanical signals promote osteogenic fate through a primary cilia-mediated mechanism. FASEB J. 2016;30:1504-11 pubmed publisher
    ..cellsin vivo Furthermore, we used an inducible Cre/Lox recombination system to delete kinesin family member 3A (Kif3a), a gene that is essential for primary cilia formation, at will in transplanted cells and their progeny, ..
  29. Zhao Y, Mu D, Wang D, Han Y, Hou C, Zhu J. Analysis of the function of KIF3A and KIF3B in the spermatogenesis in Boleophthalmus pectinirostris. Fish Physiol Biochem. 2018;44:769-788 pubmed publisher
    ..the assembly and maintenance of the flagella and intracellular transport of membrane-bound organelles required KIF3A and KIF3B...
  30. Funabashi T, Katoh Y, Okazaki M, Sugawa M, Nakayama K. Interaction of heterotrimeric kinesin-II with IFT-B-connecting tetramer is crucial for ciliogenesis. J Cell Biol. 2018;217:2867-2876 pubmed publisher
    ..assay, we identified in this study a three-to-four protein interaction involving the kinesin-II trimer KIF3A-KIF3B-KAP3 and the IFT-B-connecting tetramer IFT38-IFT52-IFT57-IFT88; among the kinesin-II subunits, KIF3B ..
  31. Lee H, Ko H. Ciliary smoothened-mediated noncanonical hedgehog signaling promotes tubulin acetylation. Biochem Biophys Res Commun. 2016;480:574-579 pubmed publisher
    ..In Kif3a-/- MEFs, which cannot form primary cilia, we observed that primary cilia were required for transducing ..
  32. Guinot A, Lehmann H, Wild P, Frew I. Combined deletion of Vhl, Trp53 and Kif3a causes cystic and neoplastic renal lesions. J Pathol. 2016;239:365-73 pubmed publisher
    ..Supporting this idea, genetic ablation of the primary cilium by deletion of the kinesin family member 3A (Kif3a) gene cooperates with loss of Vhl to accelerate cyst formation in mouse kidneys...
  33. Lu D, Rauhauser A, Li B, Ren C, McEnery K, Zhu J, et al. Loss of Glis2/NPHP7 causes kidney epithelial cell senescence and suppresses cyst growth in the Kif3a mouse model of cystic kidney disease. Kidney Int. 2016;89:1307-23 pubmed publisher
    ..The Kif3a knockout mouse is an established non-orthologous mouse model of cystic kidney disease...
  34. Möckel M, Hund C, Mayer T. Chemical Genetics Approach to Engineer Kinesins with Sensitivity towards a Small-Molecule Inhibitor of Eg5. Chembiochem. 2016;17:2042-2045 pubmed publisher
    ..Transfer of this allosteric binding site into the motor domain of the human kinesins Kif3A and Kif4A sensitizes them towards STLC...
  35. Schock E, Struve J, Chang C, Williams T, Snedeker J, Attia A, et al. A tissue-specific role for intraflagellar transport genes during craniofacial development. PLoS ONE. 2017;12:e0174206 pubmed publisher
    ..cilia during craniofacial development we conditionally deleted three separate intraflagellar transport genes, Kif3a, Ift88 and Ttc21b with three distinct drivers, Wnt1-Cre, Crect and AP2-Cre which drive recombination in neural ..
  36. Lehti M, Kotaja N, Sironen A. KIF1-binding protein interacts with KIF3A in haploid male germ cells. Reproduction. 2015;150:209-16 pubmed publisher
    ..Previously, we have demonstrated that a microtubule-based anterograde transport motor protein KIF3A is required for the sperm tail formation and nuclear shaping during spermatogenesis...
  37. Leitch C, Zaghloul N. BBS4 is necessary for ciliary localization of TrkB receptor and activation by BDNF. PLoS ONE. 2014;9:e98687 pubmed publisher
    ..Finally, we present evidence that loss of the ciliary axoneme through depletion of KIF3A impedes activation of TrkB...
  38. Hamamoto A, Yamato S, Katoh Y, Nakayama K, Yoshimura K, Takeda S, et al. Modulation of primary cilia length by melanin-concentrating hormone receptor 1. Cell Signal. 2016;28:572-84 pubmed publisher
    ..Furthermore, induction of fewer cilia by Kif3A siRNA treatment significantly decreased the MCH-mediated phosphorylation of Akt, indicating the functional ..
  39. Kim M, Suh Y, Oh J, Lee B, Kim J, Jang S. KIF3A binds to β-arrestin for suppressing Wnt/β-catenin signalling independently of primary cilia in lung cancer. Sci Rep. 2016;6:32770 pubmed publisher
    ..Here, we show that KIF3A, a member of the kinesin-2 family, plays a role in suppressing Wnt/β-catenin signalling in NSCLC cells...
  40. Chang C, Chang Y, Millington G, Brugmann S. Craniofacial Ciliopathies Reveal Specific Requirements for GLI Proteins during Development of the Facial Midline. PLoS Genet. 2016;12:e1006351 pubmed publisher
    ..of primary cilia on cranial neural crest cells, via a conditional knockout of the intraflagellar transport protein KIF3a, resulted in midfacial widening due to a gain of Hedgehog (HH) activity...
  41. Jiang L, Tam B, Ying G, Wu S, Hauswirth W, Frederick J, et al. Kinesin family 17 (osmotic avoidance abnormal-3) is dispensable for photoreceptor morphology and function. FASEB J. 2015;29:4866-80 pubmed publisher
    ..laevis photoreceptors, whereas KIF3A was restricted to the proximal axoneme...
  42. Zhang P, Rayment I, Gilbert S. Fast or Slow, Either Head Can Start the Processive Run of Kinesin-2 KIF3AC. J Biol Chem. 2016;291:4407-16 pubmed publisher
    ..The hypothesis tested was whether there is an intrinsic bias within KIF3AC such that either KIF3A or KIF3C initiates the processive run...
  43. Hoang Minh L, Deleyrolle L, Nakamura N, Parker A, Martuscello R, Reynolds B, et al. PCM1 Depletion Inhibits Glioblastoma Cell Ciliogenesis and Increases Cell Death and Sensitivity to Temozolomide. Transl Oncol. 2016;9:392-402 pubmed publisher
    ..sensitivity may be partly due to the reduced ability of PCM1-depleted cells to form primary cilia, as depletion of KIF3A also ablated GBM cells' ciliogenesis and increased their sensitivity to TMZ while preserving PCM1 localization...
  44. Rais Y, Reich A, Simsa Maziel S, Moshe M, Idelevich A, Kfir T, et al. The growth plate's response to load is partially mediated by mechano-sensing via the chondrocytic primary cilium. Cell Mol Life Sci. 2015;72:597-615 pubmed publisher
    ..chondrocytes, to understand the mechanisms mediating the participation of the primary cilium, and in particular KIF3A, in the cell's response to mechanical stimulation...
  45. Khanna H, Hurd T, Lillo C, Shu X, Parapuram S, He S, et al. RPGR-ORF15, which is mutated in retinitis pigmentosa, associates with SMC1, SMC3, and microtubule transport proteins. J Biol Chem. 2005;280:33580-7 pubmed
    ..isoform(s) with the intraflagellar transport polypeptide IFT88 as well as microtubule motor proteins, including KIF3A, p150Glued, and p50-dynamitin...
  46. Hirokawa N, Tanaka Y, Okada Y. Left-right determination: involvement of molecular motor KIF3, cilia, and nodal flow. Cold Spring Harb Perspect Biol. 2009;1:a000802 pubmed publisher
  47. Jiang S, Chen G, Feng L, Jiang Z, Yu M, Bao J, et al. Disruption of kif3a results in defective osteoblastic differentiation in dental mesenchymal stem/precursor cells via the Wnt signaling pathway. Mol Med Rep. 2016;14:1891-900 pubmed publisher
    The anterograde intraflagellar transport motor protein, kif3a, regulates the integrity of primary cilia and various cellular functions, however, the role of kif3a in dental mesenchymal stem/precursor cell differentiation remains to be ..
  48. Wang Q, Cobo Stark P, Patel V, Somlo S, Han P, Igarashi P. Adenylyl cyclase 5 deficiency reduces renal cyclic AMP and cyst growth in an orthologous mouse model of polycystic kidney disease. Kidney Int. 2018;93:403-415 pubmed publisher
    ..In Kif3a mutant cells that lack primary cilia, the formation of this regulatory complex is disrupted and cAMP levels are ..
  49. Whitehead J, Wang S, Bost Usinger L, Hoang E, Frazer K, Burnside B. Photoreceptor localization of the KIF3A and KIF3B subunits of the heterotrimeric microtubule motor kinesin II in vertebrate retina. Exp Eye Res. 1999;69:491-503 pubmed
    ..Recently, we showed that the KIF3A subunit of kinesin II is concentrated in the inner segment and connecting cilium of fish photoreceptors...
  50. Pantelidou M, Zographos S, Lederer C, Kyriakides T, Pfaffl M, Santama N. Differential expression of molecular motors in the motor cortex of sporadic ALS. Neurobiol Dis. 2007;26:577-89 pubmed
    ..No mutations causing splicing defects or altering protein-coding sequences were identified in the genes of the three proteins. The present study implicates two motor proteins as possible candidates in SALS pathology. ..
  51. Onnis A, Finetti F, Patrussi L, Gottardo M, Cassioli C, Spanò S, et al. The small GTPase Rab29 is a common regulator of immune synapse assembly and ciliogenesis. Cell Death Differ. 2015;22:1687-99 pubmed publisher
    ..These results provide a function for Rab29 as a regulator of receptor recycling and identify this GTPase as a shared participant in IS and primary cilium assembly. ..
  52. Seo Y, Park S, Lee H, Park J. Copine-7 binds to the cell surface receptor, nucleolin, and regulates ciliogenesis and Dspp expression during odontoblast differentiation. Sci Rep. 2017;7:11283 pubmed publisher
    ..The expression level of cilium components, Ift88 and Kif3a, and Dspp were increased by rCpne7...
  53. Baek H, Shin H, Kim J, Shin N, Kim S, Yi M, et al. Primary cilia modulate TLR4-mediated inflammatory responses in hippocampal neurons. J Neuroinflammation. 2017;14:189 pubmed publisher
    ..In contrast, silencing Kif3a, a key protein component of cilia, increased ARL13B ciliary protein levels and suppressed NF-?B signaling and ..
  54. Shimizu K, Shirataki H, Honda T, Minami S, Takai Y. Complex formation of SMAP/KAP3, a KIF3A/B ATPase motor-associated protein, with a human chromosome-associated polypeptide. J Biol Chem. 1998;273:6591-4 pubmed
    ..SMAP is a human counterpart of mouse KAP3 (kinesin superfamily-associated protein) that is associated with mouse KIF3A/B (a kinesin superfamily protein), which functions as a microtubule-based ATPase motor for organelle transport...
  55. Tanuma N, Nomura M, Ikeda M, Kasugai I, Tsubaki Y, Takagaki K, et al. Protein phosphatase Dusp26 associates with KIF3 motor and promotes N-cadherin-mediated cell-cell adhesion. Oncogene. 2009;28:752-61 pubmed publisher
    ..Here we undertake yeast two-hybrid screening and identify Kif3a, a motor subunit of the KIF3 heterotrimeric complex, as a novel Dusp26-binding protein...
  56. Sathish N, Zhu F, Yuan Y. Kaposi's sarcoma-associated herpesvirus ORF45 interacts with kinesin-2 transporting viral capsid-tegument complexes along microtubules. PLoS Pathog. 2009;5:e1000332 pubmed publisher
    ..In this study, ORF45 was found to interact with KIF3A, a kinesin-2 motor protein that transports cargoes along microtubules to cell periphery in a yeast two-hybrid ..
  57. Paternoster L, Standl M, Chen C, Ramasamy A, Bønnelykke K, Duijts L, et al. Meta-analysis of genome-wide association studies identifies three new risk loci for atopic dermatitis. Nat Genet. 2011;44:187-92 pubmed publisher
    ..are near genes that have been implicated in epidermal proliferation and differentiation, as well as rs2897442 in KIF3A within the cytokine cluster at 5q31.1 (OR = 1.11, P = 3.8 × 10(-8))...
  58. Lepre T, Cascella R, Ragazzo M, Galli E, Novelli G, Giardina E. Association of KIF3A, but not OVOL1 and ACTL9, with atopic eczema in Italian patients. Br J Dermatol. 2013;168:1106-8 pubmed publisher
    ..2), and in KIF3A (5q31) genes in the Italian population. Recently, these SNPs have been validated as associated to the disease...
  59. Liu Z, Rebowe R, Wang Z, Li Y, Wang Z, Depaolo J, et al. KIF3a promotes proliferation and invasion via Wnt signaling in advanced prostate cancer. Mol Cancer Res. 2014;12:491-503 pubmed publisher
    ..Here, it is demonstrated that KIF3a, a subunit of kinesin-II motor protein, functions as an agonist of the Wnt signaling pathway in prostate cancer...
  60. Shiwaku H, Umino A, Umino M, Nishikawa T. Phencyclidine-induced dysregulation of primary cilia in the rodent brain. Brain Res. 2017;1674:62-69 pubmed publisher
    ..but not methamphetamine, down-regulated mRNA expression of primary cilium morphology-related genes, including kif3a, 5-HTR6, RPGRIP1L, and TMEM67, and of genes composing the cilial Wnt/?-catenin signaling pathway, ?-catenin, syn2 ..
  61. Aizawa H, Sekine Y, Takemura R, Zhang Z, Nangaku M, Hirokawa N. Kinesin family in murine central nervous system. J Cell Biol. 1992;119:1287-96 pubmed
    ..All these members of the kinesin family are expressed in the same type of neurons, and thus each one of them may transport its specific organelle in the murine central nervous system. ..
  62. Murawala P, Tripathi M, Vyas P, Salunke A, Joseph J. Nup358 interacts with APC and plays a role in cell polarization. J Cell Sci. 2009;122:3113-22 pubmed publisher
    ..These results reveal a more active role for structural nucleoporins in regulating fundamental cellular processes than previously anticipated. ..
  63. Snedeker J, Schock E, Struve J, Chang C, Cionni M, Tran P, et al. Unique spatiotemporal requirements for intraflagellar transport genes during forebrain development. PLoS ONE. 2017;12:e0173258 pubmed publisher
    ..We have genetically ablated Kif3a, Ift88, and Ttc21b in a series of specific spatiotemporal domains...
  64. Haraguchi K, Hayashi T, Jimbo T, Yamamoto T, Akiyama T. Role of the kinesin-2 family protein, KIF3, during mitosis. J Biol Chem. 2006;281:4094-9 pubmed
    ..Kinesin-2 is composed of two microtubule-based motor subunits, KIF3A/3B, and a kinesin-associated protein known as KAP3, which links KIF3A/3B to cargo that is carried to cellular ..
  65. Hirota T, Takahashi A, Kubo M, Tsunoda T, Tomita K, Sakashita M, et al. Genome-wide association study identifies eight new susceptibility loci for atopic dermatitis in the Japanese population. Nat Genet. 2012;44:1222-6 pubmed publisher
    ..We also replicated the associations of the FLG, C11orf30, TMEM232-SLC25A46, TNFRSF6B-ZGPAT, OVOL1, ACTL9 and KIF3A-IL13 loci that were previously reported in GWAS of European and Chinese individuals and a meta-analysis of GWAS ..
  66. Kodani A, Salomé Sirerol Piquer M, Seol A, Garcia Verdugo J, Reiter J. Kif3a interacts with Dynactin subunit p150 Glued to organize centriole subdistal appendages. EMBO J. 2013;32:597-607 pubmed publisher
    Formation of cilia, microtubule-based structures that function in propulsion and sensation, requires Kif3a, a subunit of Kinesin II essential for intraflagellar transport (IFT)...
  67. Carpenter B, Barry R, Verhey K, Allen B. The heterotrimeric kinesin-2 complex interacts with and regulates GLI protein function. J Cell Sci. 2015;128:1034-50 pubmed publisher
    ..To examine a role for the heterotrimeric KIF3A-KIF3B-KAP3 kinesin-2 motor complex in regulating GLI activity, we performed a series of structure-function ..
  68. Dey S, Banker G, Ray K. Anterograde Transport of Rab4-Associated Vesicles Regulates Synapse Organization in Drosophila. Cell Rep. 2017;18:2452-2463 pubmed publisher
    ..analyses in Drosophila indicate that an association with Kinesin-2 (mediated by the tail domain of Kinesin-2α/KIF3A/KLP64D subunit) moves Rab4-associated vesicles toward the synapse...
  69. Shao Q, Luo X, Yang D, Wang C, Cheng Q, Xiang T, et al. Phospholipase Cδ1 suppresses cell migration and invasion of breast cancer cells by modulating KIF3A-mediated ERK1/2/β- catenin/MMP7 signalling. Oncotarget. 2017;8:29056-29066 pubmed publisher
    ..Furthermore, KIF3A was identified as a downstream mediator of PLCD1, and there was an inverse correlation between the expression of ..
  70. Légaré S, Chabot C, Basik M. SPEN, a new player in primary cilia formation and cell migration in breast cancer. Breast Cancer Res. 2017;19:104 pubmed publisher
    ..We also report that SPEN regulates migration in breast cells, but only in those harboring primary cilia, and that KIF3A silencing, a critical factor in primary cilia, partially reverses SPEN's effects, suggesting that SPEN may ..
  71. Jimbo T, Kawasaki Y, Koyama R, Sato R, Takada S, Haraguchi K, et al. Identification of a link between the tumour suppressor APC and the kinesin superfamily. Nat Cell Biol. 2002;4:323-7 pubmed
    ..These results suggest that APC and beta-catenin are transported along microtubules by KAP3-KIF3A-KIF3B, accumulate in the tips of membrane protrusions, and may thus regulate cell migration.
  72. Balasubramaniam M, Freed E. New insights into HIV assembly and trafficking. Physiology (Bethesda). 2011;26:236-51 pubmed publisher
    ..In this review, we highlight the current understanding of the cellular machinery involved in Gag trafficking and virus assembly. ..
  73. Uusi Rauva K, Kyttälä A, van der Kant R, Vesa J, Tanhuanpää K, Neefjes J, et al. Neuronal ceroid lipofuscinosis protein CLN3 interacts with motor proteins and modifies location of late endosomal compartments. Cell Mol Life Sci. 2012;69:2075-89 pubmed publisher
    ..The data presented in this study provide novel insights into the role of CLN3 in late endosomal/lysosomal membrane transport. ..
  74. Kang Z, Li Q, Fu P, Yan S, Guan M, Xu J, et al. Correlation of KIF3A and OVOL1, but not ACTL9, with atopic dermatitis in Chinese pediatric patients. Gene. 2015;571:249-51 pubmed publisher
    ..Three single nucleotide polymorphisms have previously been associated with AD in Europeans, rs2897442 (KIF3A), rs479844 (OVOL1) and rs2164983 (ACTL9)...
  75. Goodyear R, Lu X, Deans M, Richardson G. A tectorin-based matrix and planar cell polarity genes are required for normal collagen-fibril orientation in the developing tectorial membrane. Development. 2017;144:3978-3989 pubmed publisher
    ..Epithelial width measurements and data from Kif3acKO mice suggest, respectively, that radial stretch and cilia play little, if any, role in ..
  76. Nagata K, Puls A, Futter C, Aspenstrom P, Schaefer E, Nakata T, et al. The MAP kinase kinase kinase MLK2 co-localizes with activated JNK along microtubules and associates with kinesin superfamily motor KIF3. EMBO J. 1998;17:149-58 pubmed
  77. Ridruechai C, Mahasirimongkol S, Phromjai J, Yanai H, Nishida N, Matsushita I, et al. Association analysis of susceptibility candidate region on chromosome 5q31 for tuberculosis. Genes Immun. 2010;11:416-22 pubmed publisher
    ..Of these, 75 SNPs located within candidate genes covering SLC22A4, SLC22A5, IRF1, IL5, RAD50, IL13, IL4, KIF3A and SEPT8 were genotyped using the DigiTag2 assay...
  78. Kinzel D, Boldt K, Davis E, Burtscher I, Trumbach D, Diplas B, et al. Pitchfork regulates primary cilia disassembly and left-right asymmetry. Dev Cell. 2010;19:66-77 pubmed publisher
    ..Thus, the observation of a disassembly phenotype in vivo provides an entry point to understand and categorize ciliary disease. AUTHOR AUDIO: ..
  79. Phang H, Hoon J, Lai S, Zeng Y, Chiam K, Li H, et al. POPX2 phosphatase regulates the KIF3 kinesin motor complex. J Cell Sci. 2014;127:727-39 pubmed publisher
    ..The kinesin-2 motor is a heterotrimeric complex composed of KIF3A, KIF3B motor subunits and KAP3, the non-motor subunit, which binds the cargo...
  80. Pooranachandran N, Malicki J. Unexpected Roles for Ciliary Kinesins and Intraflagellar Transport Proteins. Genetics. 2016;203:771-85 pubmed publisher
    ..To test this possibility further, we analyzed the mutant phenotype of the zebrafish kif3a gene, which encodes the common motor subunit of heterotrimeric ciliary kinesins...
  81. Cascella R, Strafella C, Ragazzo M, Manzo L, Costanza G, Bowes J, et al. KIF3A and IL-4 are disease-specific biomarkers for psoriatic arthritis susceptibility. Oncotarget. 2017;8:95401-95411 pubmed publisher
    ..The case-control study highlighted a significant association between KIF3A/IL-4 and PsA, but not with PsV (Psoriasis Vulgaris) patients...
  82. Schonteich E, Wilson G, Burden J, Hopkins C, Anderson K, Goldenring J, et al. The Rip11/Rab11-FIP5 and kinesin II complex regulates endocytic protein recycling. J Cell Sci. 2008;121:3824-33 pubmed publisher
    ..Thus, we propose that the Rip11/FIP5-kinesin-II complex has a key role in the routing of internalized receptors through the perinuclear recycling endosomes. ..
  83. Shears S. The long-awaited demonstration of protein pyrophosphorylation by IP7 in vivo?. Proc Natl Acad Sci U S A. 2010;107:E17; author reply E18 pubmed publisher
  84. Hoang Minh L, Deleyrolle L, Siebzehnrubl D, Ugartemendia G, Futch H, Griffith B, et al. Disruption of KIF3A in patient-derived glioblastoma cells: effects on ciliogenesis, hedgehog sensitivity, and tumorigenesis. Oncotarget. 2016;7:7029-43 pubmed publisher
    b>KIF3A, a component of the kinesin-2 motor, is necessary for the progression of diverse tumor types. This is partly due to its role in regulating ciliogenesis and cell responsiveness to sonic hedgehog (SHH)...
  85. Giridhar P, Bell S, Sridharan A, Rajavelu P, Kitzmiller J, Na C, et al. Airway Epithelial KIF3A Regulates Th2 Responses to Aeroallergens. J Immunol. 2016;197:4228-4239 pubmed
    b>KIF3A, the gene encoding kinesin family member 3A, is a susceptibility gene locus associated with asthma; however, mechanisms by which KIF3A might influence the pathogenesis of the disorder are unknown...
  86. Feng D, Chen Z, Yang K, Miao S, Xu B, Kang Y, et al. The cytoplasmic tail of rhodopsin triggers rapid rod degeneration in kinesin-2 mutants. J Biol Chem. 2017;292:17375-17386 pubmed publisher
    ..Here we examined photoreceptor development in zebrafish kif3a and kif3b mutants, which affect two subunits of the kinesin-2 complex...
  87. Schock E, Brugmann S. Neural crest cells utilize primary cilia to regulate ventral forebrain morphogenesis via Hedgehog-dependent regulation of oriented cell division. Dev Biol. 2017;431:168-178 pubmed publisher
    ..We utilized the conditional ciliary mutant Wnt1-Cre;Kif3afl/fl to demonstrate that loss of primary cilia on NCCs resulted in a widened ventral forebrain...
  88. Yang Z, Goldstein L. Characterization of the KIF3C neural kinesin-like motor from mouse. Mol Biol Cell. 1998;9:249-61 pubmed
    ..Sequence and secondary structure analysis revealed that KIF3C is a member of the KIF3 family. In contrast to KIF3A and KIF3B, Northern and Western analysis indicated that KIF3C expression is highly enriched in neural tissues such ..
  89. Aronov S, Aranda G, Behar L, Ginzburg I. Visualization of translated tau protein in the axons of neuronal P19 cells and characterization of tau RNP granules. J Cell Sci. 2002;115:3817-27 pubmed
    ..methods, we show that the granules contain tau mRNA, HuD RNA-binding protein, which stabilizes mRNA, and KIF3A, a member of the kinesin microtubule-associated motor protein family involved in anterograde transport...
  90. Surpili M, Delben T, Kobarg J. Identification of proteins that interact with the central coiled-coil region of the human protein kinase NEK1. Biochemistry. 2003;42:15369-76 pubmed
    ..The proteins involved in PKD include the motor protein KIF3A and the proteins tuberin and alpha-catulin...
  91. Camargo L, Collura V, Rain J, Mizuguchi K, Hermjakob H, Kerrien S, et al. Disrupted in Schizophrenia 1 Interactome: evidence for the close connectivity of risk genes and a potential synaptic basis for schizophrenia. Mol Psychiatry. 2007;12:74-86 pubmed
  92. Lolkema M, Mans D, Snijckers C, van Noort M, van Beest M, Voest E, et al. The von Hippel-Lindau tumour suppressor interacts with microtubules through kinesin-2. FEBS Lett. 2007;581:4571-6 pubmed
    ..The interaction with kinesin-2 facilitates pVHL binding to microtubules. These data suggest that microtubule-dependent functions of pVHL are influenced by kinesin-2. ..