KIF1B

Summary

Gene Symbol: KIF1B
Description: kinesin family member 1B
Alias: CMT2, CMT2A, CMT2A1, HMSNII, KLP, NBLST1, kinesin-like protein KIF1B, kinesin superfamily protein KIF1B
Species: human
Products:     KIF1B

Top Publications

  1. Nangaku M, Sato Yoshitake R, Okada Y, Noda Y, Takemura R, Yamazaki H, et al. KIF1B, a novel microtubule plus end-directed monomeric motor protein for transport of mitochondria. Cell. 1994;79:1209-20 pubmed
    ..further elucidate the mechanism of organelle transport, we cloned a novel member of the mouse kinesin superfamily, KIF1B. This N-terminal-type motor protein is expressed ubiquitously in various kinds of tissues...
  2. Bunn R, Jensen M, Reed B. Protein interactions with the glucose transporter binding protein GLUT1CBP that provide a link between GLUT1 and the cytoskeleton. Mol Biol Cell. 1999;10:819-32 pubmed
  3. Conforti L, Buckmaster E, Tarlton A, Brown M, Lyon M, Perry V, et al. The major brain isoform of kif1b lacks the putative mitochondria-binding domain. Mamm Genome. 1999;10:617-22 pubmed
    ..identified a member of the kinesin superfamily whose predicted gene product has the N-terminal motor domain of Kif1b and a novel C-terminal cargo-binding domain homologous to Kif1a...
  4. Yang H, Chen Y, Takita J, Soeda E, Piao H, Hayashi Y. Genomic structure and mutational analysis of the human KIF1B gene which is homozygously deleted in neuroblastoma at chromosome 1p36.2. Oncogene. 2001;20:5075-83 pubmed
    ..2 in one of the 24 NB cell lines, NB-1, and cloned the human homologue (KIF1B-beta) of the mouseKif1B-beta gene in this region...
  5. Aulchenko Y, Hoppenbrouwers I, Ramagopalan S, Broer L, Jafari N, Hillert J, et al. Genetic variation in the KIF1B locus influences susceptibility to multiple sclerosis. Nat Genet. 2008;40:1402-3 pubmed publisher
    ..An rs10492972[C] variant located in the KIF1B gene was associated with MS with an odds ratio of 1.35 (P = 2.5 x 10(-10))...
  6. Zhao C, Takita J, Tanaka Y, Setou M, Nakagawa T, Takeda S, et al. Charcot-Marie-Tooth disease type 2A caused by mutation in a microtubule motor KIF1Bbeta. Cell. 2001;105:587-97 pubmed
    The kinesin superfamily motor protein KIF1B has been shown to transport mitochondria. Here, we describe an isoform of KIF1B, KIF1Bbeta, that is distinct from KIF1B in its cargo binding domain...
  7. Zhang H, Zhai Y, Hu Z, Wu C, Qian J, Jia W, et al. Genome-wide association study identifies 1p36.22 as a new susceptibility locus for hepatocellular carcinoma in chronic hepatitis B virus carriers. Nat Genet. 2010;42:755-8 pubmed publisher
    ..We identified one intronic SNP (rs17401966) in KIF1B on chromosome 1p36...
  8. Mok H, Shin H, Kim S, Lee J, Yoon J, Kim E. Association of the kinesin superfamily motor protein KIF1Balpha with postsynaptic density-95 (PSD-95), synapse-associated protein-97, and synaptic scaffolding molecule PSD-95/discs large/zona occludens-1 proteins. J Neurosci. 2002;22:5253-8 pubmed
    Mutation in KIF1B, a kinesin superfamily motor protein, causes a peripheral neuropathy known as Charcot-Marie-Tooth disease type 2A (CMT2A). Little is known, however, about how a defective KIF1B gene leads to CMT2A...
  9. Al Qahtani A, Al Anazi M, Viswan N, Khalaf N, Abdo A, Sanai F, et al. Role of single nucleotide polymorphisms of KIF1B gene in HBV-associated viral hepatitis. PLoS ONE. 2012;7:e45128 pubmed publisher
    Kinesin family member 1B (KIF1B) gene resides in the chromosomal region 1p36.22 and has been reported to have frequent deletions in a variety of human cancers...

More Information

Publications83

  1. Nagaraja G, Kandpal R. Chromosome 13q12 encoded Rho GTPase activating protein suppresses growth of breast carcinoma cells, and yeast two-hybrid screen shows its interaction with several proteins. Biochem Biophys Res Commun. 2004;313:654-65 pubmed
    ..The presence of various motifs in RhoGAP and its interaction with several other proteins suggest that the protein may regulate Rho signaling in multiple ways and possibly function in a Rho-independent manner. ..
  2. Wang Z, Gao Q, Shi J, Yang L, Zhou J, Wang X, et al. Genetic polymorphism of the kinesin-like protein KIF1B gene and the risk of hepatocellular carcinoma. PLoS ONE. 2013;8:e62571 pubmed publisher
    Frequent deletions of the kinesin-like protein gene 1B (KIF1B) have been reported in neural tumors...
  3. Schlisio S, Kenchappa R, Vredeveld L, George R, Stewart R, Greulich H, et al. The kinesin KIF1Bbeta acts downstream from EglN3 to induce apoptosis and is a potential 1p36 tumor suppressor. Genes Dev. 2008;22:884-93 pubmed publisher
  4. Chen Y, Takita J, Chen Y, Yang H, Hanada R, Yamamoto K, et al. Genomic structure and mutational analysis of the human KIF1Balpha gene located at 1p36.2 in neuroblastoma. Int J Oncol. 2003;23:737-44 pubmed
    ..Here, we identified another isoform of the human KIF1B gene, KIF1Balpha. The KIF1Balpha and KIF1Bbeta are alternative splicing products of the KIF1B gene located on 1p36...
  5. Munirajan A, Ando K, Mukai A, Takahashi M, Suenaga Y, Ohira M, et al. KIF1Bbeta functions as a haploinsufficient tumor suppressor gene mapped to chromosome 1p36.2 by inducing apoptotic cell death. J Biol Chem. 2008;283:24426-34 pubmed publisher
    ..Thus, KIF1Bbeta may act as a haploinsufficient tumor suppressor, and its allelic loss may be involved in the pathogenesis of neuroblastoma and other cancers. ..
  6. Yeh I, Lenci R, Qin Y, Buddavarapu K, Ligon A, Leteurtre E, et al. A germline mutation of the KIF1B beta gene on 1p36 in a family with neural and nonneural tumors. Hum Genet. 2008;124:279-85 pubmed publisher
    Recently, the KIF1B beta gene on 1p36, a region commonly deleted in neural crest cancers, was found to be a proapoptotic factor for sympathetic precursors...
  7. Hsieh P, He S, Buttress T, Gao H, Couchman M, Fischer R, et al. Arabidopsis male sexual lineage exhibits more robust maintenance of CG methylation than somatic tissues. Proc Natl Acad Sci U S A. 2016;113:15132-15137 pubmed publisher
    ..Arabidopsis thaliana sperm and vegetative cells-the cell types that comprise pollen-with mutations in the DRM, CMT2, and CMT3 methyltransferases...
  8. Higuchi Y, Hashiguchi A, Yuan J, Yoshimura A, Mitsui J, Ishiura H, et al. Mutations in MME cause an autosomal-recessive Charcot-Marie-Tooth disease type 2. Ann Neurol. 2016;79:659-72 pubmed publisher
    ..Our results indicate that loss-of-function MME mutations are the most frequent cause of adult-onset AR-CMT2 in Japan, and we propose that this new disease should be termed AR-CMT2T...
  9. Ando M, Hashiguchi A, Okamoto Y, Yoshimura A, Hiramatsu Y, Yuan J, et al. Clinical and genetic diversities of Charcot-Marie-Tooth disease with MFN2 mutations in a large case study. J Peripher Nerv Syst. 2017;22:191-199 pubmed publisher
    ..MFN2 is the most frequent causative gene of CMT2 in Japan...
  10. Genin E, Plutino M, Bannwarth S, Villa E, Cisneros Barroso E, Roy M, et al. CHCHD10 mutations promote loss of mitochondrial cristae junctions with impaired mitochondrial genome maintenance and inhibition of apoptosis. EMBO Mol Med. 2016;8:58-72 pubmed publisher
    ..FTD-ALS) clinical spectrum, late-onset spinal motor neuropathy (SMAJ), and Charcot-Marie-Tooth disease type 2 (CMT2)...
  11. Sabblah T, Nandini S, Ledray A, Pasos J, Calderon J, Love R, et al. A novel mouse model carrying a human cytoplasmic dynein mutation shows motor behavior deficits consistent with Charcot-Marie-Tooth type 2O disease. Sci Rep. 2018;8:1739 pubmed publisher
    ..In order to understand the onset and progression of CMT2, we generated a knock-in mouse carrying the corresponding CMT2O mutation (H304R/+)...
  12. Groth M, Moissiard G, Wirtz M, Wang H, Garcia Salinas C, Ramos Parra P, et al. MTHFD1 controls DNA methylation in Arabidopsis. Nat Commun. 2016;7:11640 pubmed publisher
    ..Comparative analysis of DNA methylation revealed that the CMT3 and CMT2 pathways involving positive feedback with H3K9me are mostly affected...
  13. Taniguchi H, Busche T, Patschkowski T, Niehaus K, Pátek M, Kalinowski J, et al. Physiological roles of sigma factor SigD in Corynebacterium glutamicum. BMC Microbiol. 2017;17:158 pubmed publisher
    ..genes related to corynomycolic acid synthesis (fadD2, pks), genes encoding corynomycolyl transferases (cop1, cmt1, cmt2, cmt3), L, D-transpeptidase (lppS), a subunit of the major cell wall channel (porH), and the envelope lipid ..
  14. Hong Y, Kang J, Kim J, Lee J, Kwak G, Hyun Y, et al. DGAT2 Mutation in a Family with Autosomal-Dominant Early-Onset Axonal Charcot-Marie-Tooth Disease. Hum Mutat. 2016;37:473-80 pubmed publisher
    ..We suggest that mutation of DGAT2 is the novel underlying cause of an autosomal-dominant axonal CMT2 neuropathy...
  15. Fu J, Dai S, Lu Y, Wu R, Wang Z, Yuan Y, et al. Similar clinical, pathological, and genetic features in Chinese patients with autosomal recessive and dominant Charcot-Marie-Tooth disease type 2K. Neuromuscul Disord. 2017;27:760-765 pubmed publisher
    ..In a series of 169 Chinese CMT patients (79 CMT1, 52 CMT2 and 38 unclassified), four unrelated patients (2...
  16. Bannerman P, Burns T, Xu J, Miers L, Pleasure D. Mice Hemizygous for a Pathogenic Mitofusin-2 Allele Exhibit Hind Limb/Foot Gait Deficits and Phenotypic Perturbations in Nerve and Muscle. PLoS ONE. 2016;11:e0167573 pubmed publisher
    Charcot-Marie-Tooth disease type 2A (CMT2A), the most common axonal form of hereditary sensory motor neuropathy, is caused by mutations of mitofusin-2 (MFN2)...
  17. Campbell P, Shen K, Sapio M, Glenn T, Talbot W, Marlow F. Unique function of Kinesin Kif5A in localization of mitochondria in axons. J Neurosci. 2014;34:14717-32 pubmed publisher
    ..Finally, concurrent loss of the kinesin-3, kif1b, or its adaptor kbp, exacerbates axonal degeneration via a nonmitochondrial cargo common to Kif5Aa...
  18. Tazir M, Hamadouche T, Nouioua S, Mathis S, Vallat J. Hereditary motor and sensory neuropathies or Charcot-Marie-Tooth diseases: an update. J Neurol Sci. 2014;347:14-22 pubmed publisher
    ..as CMT4 (A, B, C …), we propose a simplified classification such as AR CMT1 (A, B, C …), and AR CMT2 for axonal forms...
  19. Ashapkin V, Kutueva L, Vanyushin B. Plant DNA Methyltransferase Genes: Multiplicity, Expression, Methylation Patterns. Biochemistry (Mosc). 2016;81:141-51 pubmed publisher
    ..Vice versa, expression of the MET2a, MET2b, MET3, and CMT2 genes in endosperm is much more active compared with embryo...
  20. Stuppia G, Rizzo F, Riboldi G, Del Bo R, Nizzardo M, Simone C, et al. MFN2-related neuropathies: Clinical features, molecular pathogenesis and therapeutic perspectives. J Neurol Sci. 2015;356:7-18 pubmed publisher
    ..Mutations in the gene encoding MFN2 are associated with Charcot-Marie-Tooth disease type 2A (CMT2A), a neurological disorder characterized by a wide clinical phenotype that involves the central and peripheral ..
  21. Shen S, Benoy V, Bergman J, Kalin J, Frojuello M, Vistoli G, et al. Bicyclic-Capped Histone Deacetylase 6 Inhibitors with Improved Activity in a Model of Axonal Charcot-Marie-Tooth Disease. ACS Chem Neurosci. 2016;7:240-58 pubmed publisher
    ..In mutant HSPB1-expressing DRG neurons, serving as an in vitro model for CMT2, these inhibitors were able to restore the mitochondrial axonal transport deficits...
  22. Kennerson M, Kim E, Siddell A, Kidambi A, Kim S, Hong Y, et al. X-linked Charcot-Marie-Tooth disease type 6 (CMTX6) patients with a p.R158H mutation in the pyruvate dehydrogenase kinase isoenzyme 3 gene. J Peripher Nerv Syst. 2016;21:45-51 pubmed publisher
    ..This differs from demyelinating CMT1A patients and is similar to axonal CMT2A patients. The clinical, neuroimaging, and electrophysiological findings from a second CMTX6 family with the p...
  23. Zhang Y, Harris C, Liu Q, Liu W, Ausin I, Long Y, et al. Large-scale comparative epigenomics reveals hierarchical regulation of non-CG methylation in Arabidopsis. Proc Natl Acad Sci U S A. 2018;115:E1069-E1074 pubmed publisher
    ..and CMT3 were found to be required for the maintenance of asymmetric CHH methylation at nonoverlapping regions of CMT2 targeted heterochromatin...
  24. Redemann S, Lantzsch I, Lindow N, Prohaska S, Srayko M, MULLER REICHERT T. A Switch in Microtubule Orientation during C. elegans Meiosis. Curr Biol. 2018;28:2991-2997.e2 pubmed publisher
    ..We further show that this switch in microtubule orientation involves a kinesin-13 microtubule depolymerase, KLP-7, which removes laterally associated microtubules around chromosomes...
  25. Villalón E, Dale J, Jones M, Shen H, Garcia M. Exacerbation of Charcot-Marie-Tooth type 2E neuropathy following traumatic nerve injury. Brain Res. 2015;1627:143-53 pubmed publisher
    ..in combination with previously described pathology suggests that hNF-L(E397K) mice recapitulate many of clinical signs associated with CMT2. Therefore, hNF-L(E397K) mice provide a model for determining the efficacy of novel therapies.
  26. Tiwari N, Sathyanesan M, Schweinle W, Newton S. Carbamoylated erythropoietin induces a neurotrophic gene profile in neuronal cells. Prog Neuropsychopharmacol Biol Psychiatry. 2019;88:132-141 pubmed publisher
    ..Some of the regulated genes from these pathways are CAMKII, EGR1, FOS, GRIN1, KIF1B, NOTCH1...
  27. Pu J, Keren Kaplan T, Bonifacino J. A Ragulator-BORC interaction controls lysosome positioning in response to amino acid availability. J Cell Biol. 2017;216:4183-4197 pubmed publisher
    ..complex previously found to promote lysosome dispersal through coupling to the small GTPase Arl8 and the kinesins KIF1B and KIF5B...
  28. Snezhkina A, Lukyanova E, Kalinin D, Pokrovsky A, Dmitriev A, Koroban N, et al. Exome analysis of carotid body tumor. BMC Med Genomics. 2018;11:17 pubmed publisher
    ..potential driver mutations (PDMs) in 21 genes: ARNT, BAP1, BRAF, BRCA1, BRCA2, CDKN2A, CSDE1, FGFR3, IDH1, KIF1B, KMT2D, MEN1, RET, SDHA, SDHB, SDHC, SDHD, SETD2, TP53BP1, TP53BP2, and TP53I13...
  29. Sombekke M, Jafari N, Bendfeldt K, Mueller Lenke N, Radue E, Naegelin Y, et al. No influence of KIF1B on neurodegenerative markers in multiple sclerosis. Neurology. 2011;76:1843-5 pubmed publisher
  30. Hares K, Miners J, Cook A, Rice C, Scolding N, Love S, et al. Overexpression of Kinesin Superfamily Motor Proteins in Alzheimer's Disease. J Alzheimers Dis. 2017;60:1511-1524 pubmed publisher
    ..aim in the present study was to assess the expression of the anterograde kinesin superfamily motor proteins KIF5A, KIF1B, and KIF21B, and to examine their relationship to levels of hyperphosphorylated tau, amyloid-? protein precursor (..
  31. Zhang Z. Association between KIF1B rs17401966 polymorphism and hepatocellular carcinoma risk: a meta-analysis involving 17,210 subjects. Tumour Biol. 2014;35:9405-10 pubmed publisher
    Some publications have evaluated the correlation between KIF1B rs17401966 polymorphism and hepatocellular carcinoma (HCC) with conflicting results...
  32. Vitiello E, Ferreira J, Maiato H, Balda M, Matter K. The tumour suppressor DLC2 ensures mitotic fidelity by coordinating spindle positioning and cell-cell adhesion. Nat Commun. 2014;5:5826 pubmed publisher
    ..Here we demonstrate that the tumour suppressor DLC2, a negative regulator of Cdc42, and the interacting kinesin Kif1B coordinate cell junction maintenance and planar spindle positioning by regulating microtubule growth and crosstalk ..
  33. O Connell G, Chantler P, Barr T. Stroke-associated pattern of gene expression previously identified by machine-learning is diagnostically robust in an independent patient population. Genom Data. 2017;14:47-52 pubmed publisher
    ..genes (ANTXR2, STK3, PDK4, CD163, MAL, GRAP, ID3, CTSZ, KIF1B, and PLXDC2) were extracted, compared between groups, and evaluated for their discriminatory ability at ..
  34. Chiappetta C, Mancini M, Lessi F, Aretini P, De Gregorio V, Puggioni C, et al. Whole-exome analysis in osteosarcoma to identify a personalized therapy. Oncotarget. 2017;8:80416-80428 pubmed publisher
    ..We identified 18,275 somatic variations in 8,247 genes and we found three mutated genes in 7/8 (87%) samples (KIF1B, NEB and KMT2C)...
  35. Lindqvist C, Nordlund J, Ekman D, Johansson A, Moghadam B, Raine A, et al. The mutational landscape in pediatric acute lymphoblastic leukemia deciphered by whole genome sequencing. Hum Mutat. 2015;36:118-28 pubmed publisher
    ..By targeted sequencing in 168 patients, we identified KMT2D and KIF1B as novel putative driver genes...
  36. Boerkoel C, Takashima H, Garcia C, Olney R, Johnson J, Berry K, et al. Charcot-Marie-Tooth disease and related neuropathies: mutation distribution and genotype-phenotype correlation. Ann Neurol. 2002;51:190-201 pubmed
    ..The peripheral myelin protein 22 mutation W28R was associated with CMT1 and profound deafness. One patient with a CMT2 clinical phenotype had three myelin protein zero mutations (I89N+V92M+I162M)...
  37. Nagai M, Ichimiya S, Ozaki T, Seki N, Mihara M, Furuta S, et al. Identification of the full-length KIAA0591 gene encoding a novel kinesin-related protein which is mapped to the neuroblastoma suppressor gene locus at 1p36.2. Int J Oncol. 2000;16:907-16 pubmed
    ..Thus, the full-length KIAA0591 gene may be a novel member of human KIF superfamily which lacks motor domain and might function as a tumor suppressor in an epigenetic but not a classic Knudson's manner. ..
  38. Carvill G, Weckhuysen S, McMahon J, Hartmann C, Møller R, Hjalgrim H, et al. GABRA1 and STXBP1: novel genetic causes of Dravet syndrome. Neurology. 2014;82:1245-53 pubmed publisher
    ..Our results have important implications for diagnostic testing, clinical management, and genetic counseling of patients with this devastating disorder and their families. ..
  39. Gigant E, Stefanutti M, Laband K, Gluszek Kustusz A, Edwards F, Lacroix B, et al. Inhibition of ectopic microtubule assembly by the kinesin-13 KLP-7 prevents chromosome segregation and cytokinesis defects in oocytes. Development. 2017;144:1674-1686 pubmed publisher
    ..elegans oocyte, we provide novel evidence that the kinesin-13 KLP-7 promotes destabilization of the whole cellular microtubule network...
  40. Gourraud P. When is the absence of evidence, evidence of absence? Use of equivalence-based analyses in genetic epidemiology and a conclusion for the KIF1B rs10492972*C allelic association in multiple sclerosis. Genet Epidemiol. 2011;35:568-71 pubmed publisher
    ..We applied the equivalence method to genetic data to confirm that an association between the KIF1B (kinesin family member1B) rs10492972 allele and multiple sclerosis (MS), reported in Nature Genetics in 2008, is ..
  41. Rizzo F, Ronchi D, Salani S, Nizzardo M, Fortunato F, Bordoni A, et al. Selective mitochondrial depletion, apoptosis resistance, and increased mitophagy in human Charcot-Marie-Tooth 2A motor neurons. Hum Mol Genet. 2016;25:4266-4281 pubmed publisher
    Charcot-Marie-Tooth 2A (CMT2A) is an inherited peripheral neuropathy caused by mutations in MFN2, which encodes a mitochondrial membrane protein involved in mitochondrial network homeostasis...
  42. Wozniak M, Melzer M, Dorner C, Haring H, Lammers R. The novel protein KBP regulates mitochondria localization by interaction with a kinesin-like protein. BMC Cell Biol. 2005;6:35 pubmed
    ..the yeast-two-hybrid system with an amino-terminal fragment of KIF1C as a bait that is strongly homologous to KIF1B. Here we investigated the interaction of KBP and KIF1B...
  43. Booth D, Heard R, Stewart G, Cox M, Scott R, Lechner Scott J, et al. Lack of support for association between the KIF1B rs10492972[C] variant and multiple sclerosis. Nat Genet. 2010;42:469-70; author reply 470-1 pubmed publisher
  44. Guardia C, Farías G, Jia R, Pu J, Bonifacino J. BORC Functions Upstream of Kinesins 1 and 3 to Coordinate Regional Movement of Lysosomes along Different Microtubule Tracks. Cell Rep. 2016;17:1950-1961 pubmed publisher
    ..that BORC and Arl8 function upstream of two structurally distinct kinesin types: kinesin-1 (KIF5B) and kinesin-3 (KIF1Bβ and KIF1A)...
  45. Botsford B, Vuong L, Hedges T, Mendoza Santiesteban C. Characterization of Charcot-Marie-Tooth optic neuropathy. J Neurol. 2017;264:2431-2435 pubmed publisher
    ..To define and characterize the extent of optic neuropathy in patients with CMT2A and CMT1A, two patients from both sub-classifications were evaluated...
  46. Sopipong W, Tangkijvanich P, Payungporn S, Posuwan N, Poovorawan Y. The KIF1B (rs17401966) single nucleotide polymorphism is not associated with the development of HBV-related hepatocellular carcinoma in Thai patients. Asian Pac J Cancer Prev. 2013;14:2865-9 pubmed
    ..A single nucleotide polymorphism (SNP) at the KIF1B gene locus, rs17401966, has been shown to be strongly associated with the development of HBV-related HCC...
  47. Dong Z, Xu X, Du L, Yang Y, Cheng H, Zhang X, et al. Leptin-mediated regulation of MT1-MMP localization is KIF1B dependent and enhances gastric cancer cell invasion. Carcinogenesis. 2013;34:974-83 pubmed publisher
    ..that the surface expression of MT1-MMP was also enhanced by leptin, and knockdown of kinesin family member 1B (KIF1B, a microtubule plus end-directed monomeric motor protein) by small interference RNA inhibited this process...
  48. van Paassen B, Bronk M, Verhamme C, van Ruissen F, Baas F, van Spaendonck Zwarts K, et al. Pseudodominant inheritance pattern in a family with CMT2 caused by GDAP1 mutations. J Peripher Nerv Syst. 2017;22:464-467 pubmed publisher
    ..Further testing showed compound heterozygous GDAP1 mutations in the father and paternal aunt. In this CMT2 family with a pseudodominant inheritance pattern DNA-diagnostics revealed the presence of both homozygous and ..
  49. Yang Y, Fiskus W, Yong B, Atadja P, Takahashi Y, Pandita T, et al. Acetylated hsp70 and KAP1-mediated Vps34 SUMOylation is required for autophagosome creation in autophagy. Proc Natl Acad Sci U S A. 2013;110:6841-6 pubmed publisher
    ..1/3 knockout mouse embryonic fibroblasts MEFs. These findings highlight a regulatory mechanism of Vps34 activity, which involves acetylated hsp70 and KAP1-dependent SUMOylation of Vps34 bound to Beclin 1. ..
  50. Huang Y, Carson J, Barbarese E, Richter J. Facilitation of dendritic mRNA transport by CPEB. Genes Dev. 2003;17:638-53 pubmed
    ..These results suggest a mechanism whereby CPE-containing mRNAs can be transported to dendrites in a translationally dormant form, but activated at synapses in response to NMDA receptor stimulation. ..
  51. O HAGAN R, Silva M, Nguyen K, Zhang W, Bellotti S, Ramadan Y, et al. Glutamylation Regulates Transport, Specializes Function, and Sculpts the Structure of Cilia. Curr Biol. 2017;27:3430-3441.e6 pubmed publisher
    ..the deglutamylase CCPP-1 affects ciliary ultrastructure, localization of the TRP channel PKD-2 and the kinesin-3 KLP-6, and velocity of the kinesin-2 OSM-3/KIF17, whereas a cell-specific α-tubulin isotype regulates ciliary ..
  52. Koutsis G, Karadima G, Floroskufi P, Sfagos C, Vassilopoulos D, Panas M. The rs10492972 KIF1B polymorphism and disease progression in Greek patients with multiple sclerosis. J Neurol. 2011;258:1726-8 pubmed publisher
  53. Stiffler M, Grantcharova V, Sevecka M, MacBeath G. Uncovering quantitative protein interaction networks for mouse PDZ domains using protein microarrays. J Am Chem Soc. 2006;128:5913-22 pubmed
  54. Shi T, Jiang Z, Jiang R, Yin S, Wang M, Yu K, et al. Polymorphisms in the kinesin-like factor 1 B gene and risk of epithelial ovarian cancer in Eastern Chinese women. Tumour Biol. 2015;36:6919-27 pubmed publisher
    The kinesin-like factor 1 B (KIF1B) gene plays an important role in the process of apoptosis and the transformation and progression of malignant cells. Genetic variations in KIF1B may contribute to risk of epithelial ovarian cancer (EOC)...
  55. Malikov V, da Silva E, Jovasevic V, Bennett G, de Souza Aranha Vieira D, Schulte B, et al. HIV-1 capsids bind and exploit the kinesin-1 adaptor FEZ1 for inward movement to the nucleus. Nat Commun. 2015;6:6660 pubmed publisher
  56. Li S, Fell S, Surova O, Smedler E, Wallis K, Chen Z, et al. The 1p36 Tumor Suppressor KIF 1Bβ Is Required for Calcineurin Activation, Controlling Mitochondrial Fission and Apoptosis. Dev Cell. 2016;36:164-78 pubmed publisher
    b>KIF1Bβ is a candidate 1p36 tumor suppressor that regulates apoptosis in the developing sympathetic nervous system...
  57. Kuźma Kozakiewicz M, Kaźmierczak B, Chudy A, Gajewska B, Barańczyk Kuźma A. Alteration of Motor Protein Expression Involved in Bidirectional Transport in Peripheral Blood Mononuclear Cells of Patients with Amyotrophic Lateral Sclerosis. Neurodegener Dis. 2016;16:235-44 pubmed publisher
    ..We evaluated the expression of motor proteins involved in the anterograde (kinesins KIF1B, KIF5C) and retrograde (KIFC3, dynactin subunits DCTN1 and DCTN3) intracellular transport in peripheral blood ..
  58. Chen J, Wang Y, Lv W, Gan Y, Chang W, Tian N, et al. Effects of interactions between environmental factors and KIF1B genetic variants on the risk of hepatocellular carcinoma in a Chinese cohort. World J Gastroenterol. 2016;22:4183-90 pubmed publisher
    To examine the effect of the potential interaction between KIF1B variants (rs17401966 and rs3748578) and environmental factors on the risk of hepatocellular carcinoma (HCC) in a high-risk region in China...
  59. Hakonen J, Sorrentino V, Avagliano Trezza R, de Wissel M, van den Berg M, Bleijlevens B, et al. LRSAM1-mediated ubiquitylation is disrupted in axonal Charcot-Marie-Tooth disease 2P. Hum Mol Genet. 2017;26:2034-2041 pubmed publisher
    ..However, the frequency of LRSAM1 mutations in CMT2 and the functional basis for their association with disease remains unknown...
  60. Chen S, Han M, Chen W, He Y, Huang B, Zhao P, et al. KIF1B promotes glioma migration and invasion via cell surface localization of MT1-MMP. Oncol Rep. 2016;35:971-7 pubmed publisher
    ..demonstrated that membrane type 1-matrix metalloproteinase (MT1-MMP) was involved in Kinesin family member 1B (KIF1B)-modulated invasion of gastric cancer cells...
  61. Mitsugi H, Niki T, Takahashi Niki K, Tanimura K, Yoshizawa Kumagaye K, Tsunemi M, et al. Identification of the recognition sequence and target proteins for DJ-1 protease. FEBS Lett. 2013;587:2493-9 pubmed publisher
    ..5 and 0 mM NaCl. Divalent ions, especially Cu²?, were inhibitory to DJ-1's protease activity. c-abl oncogene 1 product (ABL1) and kinesin family member 1B (KIF1B) containing VKVA were digested by DJ-1?H9.
  62. Muresan Z, Muresan V. Coordinated transport of phosphorylated amyloid-beta precursor protein and c-Jun NH2-terminal kinase-interacting protein-1. J Cell Biol. 2005;171:615-25 pubmed
    ..These results indicate that the phosphorylation of APP regulates the formation of a pAPP-JIP-1 complex that accumulates in neurites independent of nonphosphorylated APP. ..
  63. Tayal P, Raj S, Sharma E, Kumar M, Dayaman V, Verma N, et al. A Botrytis cinerea KLP-7 Kinesin acts as a Virulence Determinant during Plant Infection. Sci Rep. 2017;7:10664 pubmed publisher
    ..TAIL-PCR followed by BLAST search identified the tagged gene as KLP-7 that encodes for kinesin...
  64. Zhong R, Tian Y, Liu L, Qiu Q, Wang Y, Rui R, et al. HBV-related hepatocellular carcinoma susceptibility gene KIF1B is not associated with development of chronic hepatitis B. PLoS ONE. 2012;7:e28839 pubmed publisher
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    b>KIF1B? is a kinesin-like, microtubule-based molecular motor protein involved in anterograde axonal vesicular transport in vertebrate and invertebrate neurons...
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    ..The second molecule identified is a rat homolog of murine KIF1B, a putative mitochondrial transporter...
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    ..household controls, and identified a 7- and a 10-transcript signature, both including NOD2, GBP5, IFITM1/3, KIF1B and TNIP1...
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    Inherited KIF1B loss-of-function mutations in neuroblastomas and pheochromocytomas implicate the kinesin KIF1B as a 1p36.2 tumor suppressor. However, the mechanism of tumor suppression is unknown...
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    ..Single nucleotide polymorphisms in the CD40 gene (rs6074022, rs1883832, rs1535045 and rs11086998) and the KIF1B gene (rs10492972 and rs3135388) were genotyped using TaqMan technology...
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