KIF17

Summary

Gene Symbol: KIF17
Description: kinesin family member 17
Alias: KIF17B, KIF3X, KLP-2, OSM-3, kinesin-like protein KIF17, KIF17 variant protein, KIF3-related motor protein
Species: human
Products:     KIF17

Top Publications

  1. Setou M, Nakagawa T, Seog D, Hirokawa N. Kinesin superfamily motor protein KIF17 and mLin-10 in NMDA receptor-containing vesicle transport. Science. 2000;288:1796-802 pubmed
    ..N-methyl-D-aspartate (NMDA) receptor 2B (NR2B subunit) show that they are transported along microtubules by KIF17, a neuron-specific molecular motor in neuronal dendrites...
  2. Guillaud L, Setou M, Hirokawa N. KIF17 dynamics and regulation of NR2B trafficking in hippocampal neurons. J Neurosci. 2003;23:131-40 pubmed
    b>KIF17, a recently characterized member of the kinesin superfamily proteins, has been proposed to bind in vitro to a protein complex containing mLin10 (Mint1/X11) and the NR2B subunit of the NMDA receptors (NMDARs)...
  3. Engelke M, Waas B, Kearns S, Suber A, Boss A, Allen B, et al. Acute Inhibition of Heterotrimeric Kinesin-2 Function Reveals Mechanisms of Intraflagellar Transport in Mammalian Cilia. Curr Biol. 2019;: pubmed publisher
    ..We also demonstrate that the kinesin-2 family members KIF3A/KIF3C and KIF17 cannot rescue ciliogenesis in Kif3a/Kif3b double-knockout cells or delay the loss of assembled cilia upon i3A/i3B ..
  4. Wang H, Zhang Y, Tang F, Pan M, Wan X, Li X, et al. Rab23/Kif17 regulate meiotic progression in oocytes by modulating tubulin acetylation and actin dynamics. Development. 2019;146: pubmed publisher
    ..Here, we report that the vesicle trafficking protein Rab23, a GTPase, drives the motor protein Kif17, and that this is important for spindle organization and actin dynamics during mouse oocyte meiosis...
  5. Lewis T, Kundinger S, Link B, Insinna C, Besharse J. Kif17 phosphorylation regulates photoreceptor outer segment turnover. BMC Cell Biol. 2018;19:25 pubmed publisher
    b>KIF17, a kinesin-2 motor that functions in intraflagellar transport, can regulate the onset of photoreceptor outer segment development. However, the function of KIF17 in a mature photoreceptor remains unclear...
  6. Liu M, Liu Y, Hou B, Bu D, Shi L, Gu X, et al. Kinesin superfamily protein 17 contributes to the development of bone cancer pain by participating in NR2B transport in the spinal cord of mice. Oncol Rep. 2015;33:1365-71 pubmed publisher
    ..Kinesin superfamily protein 17 (KIF17), a recently characterized member of the kinesin superfamily proteins, has been demonstrated to transport and ..
  7. Takao D, Dishinger J, Kee H, Pinskey J, Allen B, Verhey K. An assay for clogging the ciliary pore complex distinguishes mechanisms of cytosolic and membrane protein entry. Curr Biol. 2014;24:2288-94 pubmed publisher
    ..of NUP62-Fv attenuated (1) active transport of BSA into the nuclear compartment and (2) the kinesin-2 motor KIF17 into the ciliary compartment...
  8. Terauchi A, Timmons K, Kikuma K, Pechmann Y, Kneussel M, Umemori H. Selective synaptic targeting of the excitatory and inhibitory presynaptic organizers FGF22 and FGF7. J Cell Sci. 2015;128:281-92 pubmed publisher
    ..Excitatory synaptic targeting of FGF22 requires the motor proteins KIF3A and KIF17 and the adaptor protein SAP102 (also known as DLG3)...
  9. Broekhuis J, Verhey K, Jansen G. Regulation of cilium length and intraflagellar transport by the RCK-kinases ICK and MOK in renal epithelial cells. PLoS ONE. 2014;9:e108470 pubmed publisher
    ..IFT motor, complex A protein IFT43, complex B protein IFT20, BBSome protein BBS8 and homodimeric kinesin KIF17, whose function in mammalian cilia is unclear. Interestingly, all five proteins moved at ∼0...

More Information

Publications44

  1. Li X, Zhang W, Zhang C, Yi Z, Zhang D, Gong W, et al. Common variants of the PINK1 and PARL genes do not confer genetic susceptibility to schizophrenia in Han Chinese. Mol Genet Genomics. 2015;290:585-92 pubmed publisher
    ..032), is associated with the expression of a schizophrenia susceptible gene KIF17 according to the expression quantitative trait locus (eQTL) analysis...
  2. Williams C, McIntyre J, Norris S, Jenkins P, Zhang L, Pei Q, et al. Direct evidence for BBSome-associated intraflagellar transport reveals distinct properties of native mammalian cilia. Nat Commun. 2014;5:5813 pubmed publisher
    ..Proximal and distal axonemes of these neurons show no bias towards IFT kinesin-2 choice, and Kif17 homodimer is dispensable for distal segment IFT...
  3. Cai D, McEwen D, Martens J, Meyhofer E, Verhey K. Single molecule imaging reveals differences in microtubule track selection between Kinesin motors. PLoS Biol. 2009;7:e1000216 pubmed publisher
    ..In contrast, individual Kinesin-2 (KIF17) and Kinesin-3 (KIF1A) motors do not select subsets of microtubules...
  4. Lewis T, Kundinger S, Pavlovich A, Bostrom J, Link B, Besharse J. Cos2/Kif7 and Osm-3/Kif17 regulate onset of outer segment development in zebrafish photoreceptors through distinct mechanisms. Dev Biol. 2017;425:176-190 pubmed publisher
    Zebrafish morphants of osm-3/kif17, a kinesin-2 family member and intraflagellar transport motor, have photoreceptor outer segments that are dramatically reduced in number and size...
  5. Tindi J, Chávez A, Cvejic S, Calvo Ochoa E, Castillo P, Jordan B. ANKS1B Gene Product AIDA-1 Controls Hippocampal Synaptic Transmission by Regulating GluN2B Subunit Localization. J Neurosci. 2015;35:8986-96 pubmed publisher
    ..associates with GluN2B and with the adaptor protein Ca(2+)/calmodulin-dependent serine protein kinase and kinesin KIF17, which regulate the transport of GluN2B-containing NMDARs from the endoplasmic reticulum (ER) to synapses...
  6. Hu H, Umemori H, Hsueh Y. Postsynaptic SDC2 induces transsynaptic signaling via FGF22 for bidirectional synaptic formation. Sci Rep. 2016;6:33592 pubmed publisher
    ..Meanwhile, via regulation of the KIF17 motor, CaMKII (activated by the NMDAR pathway) may further facilitate FGF22 targeting to dendritic filopodia that ..
  7. Franker M, Esteves da Silva M, Tas R, Tortosa E, Cao Y, Frias C, et al. Three-Step Model for Polarized Sorting of KIF17 into Dendrites. Curr Biol. 2016;26:1705-1712 pubmed publisher
    ..The kinesin-2 family protein KIF17 is a dendrite-specific motor protein and has been shown to interact with several dendritic cargoes [3-7]...
  8. Insinna C, Luby Phelps K, Link B, Besharse J. Analysis of IFT kinesins in developing zebrafish cone photoreceptor sensory cilia. Methods Cell Biol. 2009;93:219-34 pubmed publisher
    ..or genetic mutations of IFT components in zebrafish and detail a general experimental approach that has enabled us to study the function of the two anterograde IFT motors, KIF17 and kinesin II, in zebrafish cone photoreceptors.
  9. Leaf A, von Zastrow M. Dopamine receptors reveal an essential role of IFT-B, KIF17, and Rab23 in delivering specific receptors to primary cilia. elife. 2015;4: pubmed publisher
    ..requiring the receptor cytoplasmic tail, the intraflagellar transport complex-B (IFT-B), and ciliary kinesin KIF17. This targeting mechanism critically depends on Rab23, a small guanine nucleotide binding protein that has ..
  10. Seneviratne A, Turan Z, Hermant A, Lecine P, Smith W, Borg J, et al. Modulation of estrogen related receptor alpha activity by the kinesin KIF17. Oncotarget. 2017;8:50359-50375 pubmed publisher
    ..We identified an interaction between ERR1 and KIF17, a kinesin-2 family microtubule motor, in a yeast-2-hybrid screen...
  11. Wang G, Zhang H, Wang L, Wang Y, Huang H, Sun F. Ca(2+)/Calmodulin-Dependent Protein Kinase IV Promotes Interplay of Proteins in Chromatoid Body of Male Germ Cells. Sci Rep. 2015;5:12126 pubmed publisher
    ..body by immunoprecipitation: mouse VASA homologue (MVH), mouse homologue of PIWI, PIWIL1 (MIWI), and kinesin KIF17b. Importantly, interplay between KIF17b and MVH or MIWI can be potentially regulated by CaMKIV...
  12. Masyukova S, Landis D, Henke S, Williams C, Pieczynski J, Roszczynialski K, et al. A Screen for Modifiers of Cilia Phenotypes Reveals Novel MKS Alleles and Uncovers a Specific Genetic Interaction between osm-3 and nphp-4. PLoS Genet. 2016;12:e1005841 pubmed publisher
    ..Moreover, data suggest human OSM-3 homolog (Kif17) could act as a modifying locus affecting disease penetrance or expressivity in NPHP patients.
  13. Jiang L, Tam B, Ying G, Wu S, Hauswirth W, Frederick J, et al. Kinesin family 17 (osmotic avoidance abnormal-3) is dispensable for photoreceptor morphology and function. FASEB J. 2015;29:4866-80 pubmed publisher
    ..KIF3) kinesin-2 motors are required to establish sensory cilia by intraflagellar transport (IFT) where KIF3 and KIF17 cooperate to build the axoneme core and KIF17 builds the distal segments...
  14. Yi P, Xie C, Ou G. The kinases male germ cell-associated kinase and cell cycle-related kinase regulate kinesin-2 motility in Caenorhabditis elegans neuronal cilia. Traffic. 2018;19:522-535 pubmed publisher
    ..isolate suppressors that rescue the ciliary defects of OSM-3-kinesin (homolog of mammalian homodimeric kinesin-2 KIF17) mutants in Caenorhabditis elegans. We identified the C...
  15. Silva M, Morsci N, Nguyen K, Rizvi A, Rongo C, Hall D, et al. Cell-Specific ?-Tubulin Isotype Regulates Ciliary Microtubule Ultrastructure, Intraflagellar Transport, and Extracellular Vesicle Biology. Curr Biol. 2017;27:968-980 pubmed publisher
    ..tba-6 regulates velocities and cargoes of intraflagellar transport (IFT) kinesin-2 motors kinesin-II and OSM-3/KIF17 without affecting kinesin-3 KLP-6 motility...
  16. Lim Y, Tang B. A role for Rab23 in the trafficking of Kif17 to the primary cilium. J Cell Sci. 2015;128:2996-3008 pubmed publisher
    ..Rab23 in the ciliary targeting of known cargoes and found that ciliary localization of the kinesin-2 motor protein Kif17 was disrupted in Rab23-depleted cells...
  17. Ratta Apha W, Mouri K, Boku S, Ishiguro H, Okazaki S, Otsuka I, et al. A decrease in protein level and a missense polymorphism of KIF17 are associated with schizophrenia. Psychiatry Res. 2015;230:424-9 pubmed publisher
    ..The kinesin superfamily motor protein 17 (KIF17) is known as a transporter of NR2B...
  18. Schwarz N, Lane A, Jovanovic K, Parfitt D, Aguilà M, Thompson C, et al. Arl3 and RP2 regulate the trafficking of ciliary tip kinesins. Hum Mol Genet. 2017;26:2480-2492 pubmed publisher
    ..intraflagellar transport (IFT) is mediated by kinesin motor proteins; however, the function of the homodimeric Kif17 motor in cilia is poorly understood, whereas Kif7 is known to play an important role in stabilizing cilia tips...
  19. Hammond J, Blasius T, Soppina V, Cai D, Verhey K. Autoinhibition of the kinesin-2 motor KIF17 via dual intramolecular mechanisms. J Cell Biol. 2010;189:1013-25 pubmed publisher
    ..We show that the homodimeric kinesin-2 motor KIF17 is kept in an inactive state in the absence of cargo...
  20. Luo W, Ruba A, Takao D, Zweifel L, Lim R, Verhey K, et al. Axonemal Lumen Dominates Cytosolic Protein Diffusion inside the Primary Cilium. Sci Rep. 2017;7:15793 pubmed publisher
    ..primarily utilize the IFT path in the anterograde direction, differences are observed in the retrograde direction where IFT20 only utilizes IFT, and approximately half of KIF17 and one third of ?-tubulin utilizes diffusion besides IFT.
  21. Nagata K, Puls A, Futter C, Aspenstrom P, Schaefer E, Nakata T, et al. The MAP kinase kinase kinase MLK2 co-localizes with activated JNK along microtubules and associates with kinesin superfamily motor KIF3. EMBO J. 1998;17:149-58 pubmed
  22. Takao D, Wang L, Boss A, Verhey K. Protein Interaction Analysis Provides a Map of the Spatial and Temporal Organization of the Ciliary Gating Zone. Curr Biol. 2017;27:2296-2306.e3 pubmed publisher
    ..of the nephronophthisis (NPHP) proteins NPHP4 and NPHP5 interact with the axoneme-associated kinesin-2 motor KIF17 and thus spatially map to the inner region of the ciliary gating zone...
  23. Funabashi T, Katoh Y, Michisaka S, Terada M, Sugawa M, Nakayama K. Ciliary entry of KIF17 is dependent on its binding to the IFT-B complex via IFT46-IFT56 as well as on its nuclear localization signal. Mol Biol Cell. 2017;28:624-633 pubmed publisher
    ..However, the role of KIF17, a homodimeric kinesin-2 protein, in protein trafficking has not been fully understood in vertebrate cilia...
  24. Acharya B, Espenel C, Libanje F, Raingeaud J, Morgan J, Jaulin F, et al. KIF17 regulates RhoA-dependent actin remodeling at epithelial cell-cell adhesions. J Cell Sci. 2016;129:957-70 pubmed publisher
    The kinesin KIF17 localizes at microtubule plus-ends where it contributes to regulation of microtubule stabilization and epithelial polarization...
  25. Jaulin F, Kreitzer G. KIF17 stabilizes microtubules and contributes to epithelial morphogenesis by acting at MT plus ends with EB1 and APC. J Cell Biol. 2010;190:443-60 pubmed publisher
    ..We show that the anterograde kinesin KIF17 localizes to MT plus ends, stabilizes MTs, and affects epithelial architecture...
  26. Chennathukuzhi V, Morales C, El Alfy M, Hecht N. The kinesin KIF17b and RNA-binding protein TB-RBP transport specific cAMP-responsive element modulator-regulated mRNAs in male germ cells. Proc Natl Acad Sci U S A. 2003;100:15566-71 pubmed
    ..Targeted inactivation of TB-RBP leads to abnormalities in fertility and behavior. A testis-enriched kinesin KIF17b coimmunoprecipitates with TB-RBP in a RNA-protein complex containing specific cAMP-responsive element modulator (..
  27. Pooranachandran N, Malicki J. Unexpected Roles for Ciliary Kinesins and Intraflagellar Transport Proteins. Genetics. 2016;203:771-85 pubmed publisher
    ..of the Kif3c-related protein, encoded by the kif3c-like (kif3cl) gene, and the homodimeric ciliary kinesin, kif17, are dispensable for photoreceptor morphogenesis...
  28. O HAGAN R, Silva M, Nguyen K, Zhang W, Bellotti S, Ramadan Y, et al. Glutamylation Regulates Transport, Specializes Function, and Sculpts the Structure of Cilia. Curr Biol. 2017;27:3430-3441.e6 pubmed publisher
    ..ultrastructure, localization of the TRP channel PKD-2 and the kinesin-3 KLP-6, and velocity of the kinesin-2 OSM-3/KIF17, whereas a cell-specific α-tubulin isotype regulates ciliary ultrastructure, intraflagellar transport, and ..
  29. Tarabeux J, Champagne N, Brustein E, Hamdan F, Gauthier J, Lapointe M, et al. De novo truncating mutation in Kinesin 17 associated with schizophrenia. Biol Psychiatry. 2010;68:649-56 pubmed publisher
    ..The gene encoding the synaptic motor protein kinesin 17 (KIF17) involved in glutamatergic synapse is a candidate gene for SCZ...
  30. Sati L, Seval Celik Y, Unek G, Korgun E, Demir R. The presence of kinesin superfamily motor proteins KIFC1 and KIF17 in normal and pathological human placenta. Placenta. 2009;30:848-54 pubmed publisher
    ..Therefore, in this study we aimed to investigate the presence and cellular localization of KIFC1 and KIF17 in normal and pathological human placentas...
  31. Milic B, Andreasson J, Hogan D, Block S. Intraflagellar transport velocity is governed by the number of active KIF17 and KIF3AB motors and their motility properties under load. Proc Natl Acad Sci U S A. 2017;114:E6830-E6838 pubmed publisher
    Homodimeric KIF17 and heterotrimeric KIF3AB are processive, kinesin-2 family motors that act jointly to carry out anterograde intraflagellar transport (IFT), ferrying cargo along microtubules (MTs) toward the tips of cilia...
  32. Bai X, Karasmanis E, Spiliotis E. Septin 9 interacts with kinesin KIF17 and interferes with the mechanism of NMDA receptor cargo binding and transport. Mol Biol Cell. 2016;27:897-906 pubmed publisher
    ..Here we describe a novel interaction between KIF17, a kinesin 2 family motor, and septin 9 (SEPT9)...
  33. Kottyan L, Davis B, Sherrill J, Liu K, Rochman M, Kaufman K, et al. Genome-wide association analysis of eosinophilic esophagitis provides insight into the tissue specificity of this allergic disease. Nat Genet. 2014;46:895-900 pubmed publisher
    ..8×10(-2)<P<5.1×10(-11)). We propose a model to explain the tissue-specific nature of EoE that involves the interplay of allergic sensitization with an EoE-specific, IL-13-inducible esophageal response involving CAPN14. ..
  34. Acharya B, Espenel C, Kreitzer G. Direct regulation of microtubule dynamics by KIF17 motor and tail domains. J Biol Chem. 2013;288:32302-13 pubmed publisher
    b>KIF17 is a kinesin-2 family motor that interacts with EB1 at microtubule (MT) plus-ends and contributes to MT stabilization in epithelial cells. The mechanism by which KIF17 affects MTs and how its activity is regulated are not yet known...
  35. Macho B, Brancorsini S, Fimia G, Setou M, Hirokawa N, Sassone Corsi P. CREM-dependent transcription in male germ cells controlled by a kinesin. Science. 2002;298:2388-90 pubmed
    ..We found that ACT selectively associates with KIF17b, a kinesin highly expressed in male germ cells...