KIF11

Summary

Gene Symbol: KIF11
Description: kinesin family member 11
Alias: EG5, HKSP, KNSL1, MCLMR, TRIP5, kinesin-like protein KIF11, TR-interacting protein 5, TRIP-5, kinesin-like protein 1, kinesin-like spindle protein HKSP, kinesin-related motor protein Eg5, thyroid receptor-interacting protein 5
Species: human
Products:     KIF11

Top Publications

  1. Blangy A, Lane H, d Hérin P, Harper M, Kress M, Nigg E. Phosphorylation by p34cdc2 regulates spindle association of human Eg5, a kinesin-related motor essential for bipolar spindle formation in vivo. Cell. 1995;83:1159-69 pubmed
    We have isolated a human homolog of Xenopus Eg5, a kinesin-related motor protein implicated in the assembly and dynamics of the mitotic spindle...
  2. Grarup N, Rose C, Andersson E, Andersen G, Nielsen A, Albrechtsen A, et al. Studies of association of variants near the HHEX, CDKN2A/B, and IGF2BP2 genes with type 2 diabetes and impaired insulin release in 10,705 Danish subjects: validation and extension of genome-wide association studies. Diabetes. 2007;56:3105-11 pubmed publisher
    ..the type 2 diabetes susceptibility alleles identified in six recent genome-wide association studies in the HHEX/KIF11/IDE (rs1111875), CDKN2A/B (rs10811661), and IGF2BP2 (rs4402960) loci, as well as the intergenic rs9300039 variant...
  3. Furukawa Y, Shimada T, Furuta H, Matsuno S, Kusuyama A, Doi A, et al. Polymorphisms in the IDE-KIF11-HHEX gene locus are reproducibly associated with type 2 diabetes in a Japanese population. J Clin Endocrinol Metab. 2008;93:310-4 pubmed
    ..study in the French population has detected that novel single-nucleotide polymorphisms (SNPs) in the IDE-KIF11-HHEX gene locus and the SLC30A8 gene locus are associated with susceptibility to type 2 diabetes...
  4. Ostergaard P, Simpson M, Mendola A, Vasudevan P, Connell F, van Impel A, et al. Mutations in KIF11 cause autosomal-dominant microcephaly variably associated with congenital lymphedema and chorioretinopathy. Am J Hum Genet. 2012;90:356-62 pubmed publisher
    We have identified KIF11 mutations in individuals with syndromic autosomal-dominant microcephaly associated with lymphedema and/or chorioretinopathy...
  5. Sun D, Lü J, Ding K, Bi D, Niu Z, Cao Q, et al. The expression of Eg5 predicts a poor outcome for patients with renal cell carcinoma. Med Oncol. 2013;30:476 pubmed publisher
    b>Eg5 is a member of the kinesin family of proteins, which associates with bipolar spindle formation in dividing tumor cells during mitosis...
  6. Tao W, South V, Diehl R, Davide J, Sepp Lorenzino L, Fraley M, et al. An inhibitor of the kinesin spindle protein activates the intrinsic apoptotic pathway independently of p53 and de novo protein synthesis. Mol Cell Biol. 2007;27:689-98 pubmed
    ..Thus, KSP inhibitors should be active in p53-deficient tumors. ..
  7. Weihofen A, Ostaszewski B, Minami Y, Selkoe D. Pink1 Parkinson mutations, the Cdc37/Hsp90 chaperones and Parkin all influence the maturation or subcellular distribution of Pink1. Hum Mol Genet. 2008;17:602-16 pubmed
    ..Finally, we document the influence of Parkin on Pink1 subcellular distribution, providing further evidence for a common pathogenic pathway in recessive PD. ..
  8. Hu C, Zhang R, Wang C, Wang J, Ma X, Lu J, et al. PPARG, KCNJ11, CDKAL1, CDKN2A-CDKN2B, IDE-KIF11-HHEX, IGF2BP2 and SLC30A8 are associated with type 2 diabetes in a Chinese population. PLoS ONE. 2009;4:e7643 pubmed publisher
    ..We confirmed the effects of SNPs from PPARG, KCNJ11, CDKAL1, CDKN2A-CDKN2B, IDE-KIF11-HHEX, IGF2BP2 and SLC30A8 on risk for type 2 diabetes, with odds ratios ranging from 1.114 to 1...
  9. Bartoli K, Jakovljevic J, Woolford J, Saunders W. Kinesin molecular motor Eg5 functions during polypeptide synthesis. Mol Biol Cell. 2011;22:3420-30 pubmed publisher
    The kinesin-related molecular motor Eg5 plays roles in cell division, promoting spindle assembly. We show that during interphase Eg5 is associated with ribosomes and is required for optimal nascent polypeptide synthesis...

More Information

Publications117 found, 100 shown here

  1. Hazan F, Ostergaard P, Ozturk T, Kantekin E, Atlihan F, Jeffery S, et al. A novel KIF11 mutation in a Turkish patient with microcephaly, lymphedema, and chorioretinal dysplasia from a consanguineous family. Am J Med Genet A. 2012;158A:1686-9 pubmed publisher
    ..Recently, mutations in KIF11 have been demonstrated to cause dominantly inherited MLCRD syndrome...
  2. Liu M, Li D, Sun L, Chen J, Sun X, Zhang L, et al. Modulation of Eg5 activity contributes to mitotic spindle checkpoint activation and Tat-mediated apoptosis in CD4-positive T-lymphocytes. J Pathol. 2014;233:138-47 pubmed publisher
    ..In this study, we provide evidence that Tat interacts with Eg5, a microtubule-associated motor protein, and allosterically modulates the ATPase activity of Eg5 by affecting ADP ..
  3. Sladek R, Rocheleau G, Rung J, Dina C, Shen L, Serre D, et al. A genome-wide association study identifies novel risk loci for type 2 diabetes. Nature. 2007;445:881-5 pubmed
    ..linkage disequilibrium blocks that contain genes potentially involved in beta-cell development or function (IDE-KIF11-HHEX and EXT2-ALX4)...
  4. Rapley J, Nicolas M, Groen A, Regué L, Bertran M, Caelles C, et al. The NIMA-family kinase Nek6 phosphorylates the kinesin Eg5 at a novel site necessary for mitotic spindle formation. J Cell Sci. 2008;121:3912-21 pubmed publisher
    ..Herein we show that Nek6 is constitutively associated with Eg5 (also known as Kinesin-5 and Kif11), a kinesin that is necessary for spindle bipolarity...
  5. Wakana Y, Villeneuve J, van Galen J, Cruz Garcia D, Tagaya M, Malhotra V. Kinesin-5/Eg5 is important for transport of CARTS from the trans-Golgi network to the cell surface. J Cell Biol. 2013;202:241-50 pubmed publisher
    ..Disrupting the function of its mammalian orthologue, Eg5, in HeLa cells inhibited secretion of a protein called pancreatic adenocarcinoma up-regulated factor (PAUF) but, ..
  6. Xiao Y, Xu P, Fan H, Baudouin L, Xia W, Bocs S, et al. The genome draft of coconut (Cocos nucifera). Gigascience. 2017;6:1-11 pubmed publisher
    ..is less than in Phoenix dactylifera (PDK30: 28 889), Phoenix dactylifera (DPV01: 41 660), and Elaeis guineensis (EG5: 34 802). BUSCO evaluation demonstrated that the obtained scaffold sequences covered 90...
  7. Magor G, Tallack M, Gillinder K, Bell C, McCallum N, Williams B, et al. KLF1-null neonates display hydrops fetalis and a deranged erythroid transcriptome. Blood. 2015;125:2405-17 pubmed publisher
    ..We identify novel KLF1 target genes including KIF23 and KIF11 which are required for proper cytokinesis...
  8. Lee D, Kessel E, Lehto T, Liu X, Yoshinaga N, Padari K, et al. Systemic Delivery of Folate-PEG siRNA Lipopolyplexes with Enhanced Intracellular Stability for In Vivo Gene Silencing in Leukemia. Bioconjug Chem. 2017;28:2393-2409 pubmed publisher
    ..stability by FRET using double-labeled siRNA; and correlated results with knockdown of eGFPLuc protein and EG5 mRNA expression...
  9. Wen Y, Zhao S, Chao L, Yu H, Song C, Shen Y, et al. The protective role of antifreeze protein 3 on the structure and function of mature mouse oocytes in vitrification. Cryobiology. 2014;69:394-401 pubmed publisher
    ..On the contrary, the expression of cold inducible RNA-binding protein (Cirbp) and kinesin-5 motor protein (Eg5) were up-regulated in the vitrification group compared to the remaining groups...
  10. Ak H, Zeybek B, Atay S, Askar N, Akdemir A, Aydin H. Microarray gene expression analysis of uterosacral ligaments in uterine prolapse. Clin Biochem. 2016;49:1238-1242 pubmed publisher
    ..28464e-013). KIF11 gene was found to be significantly down-regulated in patients with ?3 deliveries compared to patients with <3 ..
  11. Chen W, Yang L, Xu L, Cheng L, Qian Q, Sun L, et al. Bioinformatics analysis revealing prognostic significance of RRM2 gene in breast cancer. Biosci Rep. 2019;39: pubmed publisher
    ..Besides, a positive correlation between RRM2 and KIF11 genes was confirmed...
  12. Haney S, Zhao J, Tiwari S, Eng K, Guey L, Tien E. RNAi screening in primary human hepatocytes of genes implicated in genome-wide association studies for roles in type 2 diabetes identifies roles for CAMK1D and CDKAL1, among others, in hepatic glucose regulation. PLoS ONE. 2013;8:e64946 pubmed publisher
    ..Of the genes that affect both of these processes, CAMK1D, TSPAN8 and KIF11 affect the localization of a mediator of both gluconeogenesis and glycolysis regulation, CRTC2, to the nucleus in ..
  13. Bougé A, Parmentier M. Tau excess impairs mitosis and kinesin-5 function, leading to aneuploidy and cell death. Dis Model Mech. 2016;9:307-19 pubmed publisher
    ..the inhibition of the function of the kinesin Klp61F, the Drosophila homologue of kinesin-5 (also called Eg5 or KIF11)...
  14. Wang Y, Qin T, Hu W, Chen B, Dai M, Xu G. Genome-Wide Methylation Patterns in Androgen-Independent Prostate Cancer Cells: A Comprehensive Analysis Combining MeDIP-Bisulfite, RNA, and microRNA Sequencing Data. Genes (Basel). 2018;9: pubmed publisher
    ..the networks, NEDD4L and PBX3 were targeted by SOX5, while GNAQ, ANLN, and KIF11 were targeted by miR-429...
  15. Fujiwara Y, Saito M, Robles A, Nishida M, Takeshita F, Watanabe M, et al. A Nucleolar Stress-Specific p53-miR-101 Molecular Circuit Functions as an Intrinsic Tumor-Suppressor Network. EBioMedicine. 2018;33:33-48 pubmed publisher
    ..miR-101 induced G2 phase-specific feedback regulation of p53 through direct repression of its target, EG5, resulting in elevated phosphorylation of ATM...
  16. Li S, Xuan Y, Gao B, Sun X, Miao S, Lu T, et al. Identification of an eight-gene prognostic signature for lung adenocarcinoma. Cancer Manag Res. 2018;10:3383-3392 pubmed publisher
    ..In our study, we identified eight candidate genes (DLGAP5, KIF11, RAD51AP1, CCNB1, AURKA, CDC6, OIP5 and NCAPG) closely related to survival in LUAD...
  17. Olvera García G, Aguilar García T, Gutiérrez Jasso F, Imaz Rosshandler I, Rangel Escareño C, Orozco L, et al. A transcriptome-based model of central memory CD4 T cell death in HIV infection. BMC Genomics. 2016;17:956 pubmed
    ..but also arrest in G2/M (increased CHK1, RBBP8, KIF11, etc.)...
  18. Vallot A, Leontiou I, Cladière D, El Yakoubi W, Bolte S, Buffin E, et al. Tension-Induced Error Correction and Not Kinetochore Attachment Status Activates the SAC in an Aurora-B/C-Dependent Manner in Oocytes. Curr Biol. 2018;28:130-139.e3 pubmed publisher
    ..Treatment of oocytes in late prometaphase I with Eg5 kinesin inhibitor affects spindle tension, but not attachments, as we show here using an optimized protocol for ..
  19. Sanaei B, Movaghar B, Valojerdi M, Ebrahimi B, Bazrgar M, Jafarpour F, et al. An improved method for vitrification of in vitro matured ovine oocytes; beneficial effects of Ethylene Glycol Tetraacetic acid, an intracellular calcium chelator. Cryobiology. 2018;84:82-90 pubmed publisher
    ..Also, mRNA expression levels of six candidate genes (KIF11, KIF2C, CENP-E, KIF20A, KIF4A and KIF2A), were quantitatively evaluated by RT-PCR...
  20. Müller K, Klein P, Heissig P, Roidl A, Wagner E. EGF receptor targeted lipo-oligocation polyplexes for antitumoral siRNA and miRNA delivery. Nanotechnology. 2016;27:464001 pubmed
    ..RNAi) triggered antitumoral effects were observed for two different therapeutic RNAs, a miRNA-200c mimic or EG5 siRNA. Using polyplexes modified with a ratio of 0...
  21. Kaczmarczyk A, Sullivan K. CENP-W plays a role in maintaining bipolar spindle structure. PLoS ONE. 2014;9:e106464 pubmed publisher
    ..of centrosome separation by monastrol reduced the incidence of spindle pole fragmentation, indicating that Eg5 plays a role in spindle pole disruption...
  22. Liang Y, Yang W. Kinesins in MAPK cascade: How kinesin motors are involved in the MAPK pathway?. Gene. 2019;684:1-9 pubmed publisher
    ..the chemosensitivity of osteosarcoma cells to drugs, Kinesin-3 family motor KIF13B and Kinesin-5 family motor Eg5 perform functions in regulating p38 to regulate the myelination of nervous system and facilitate the spindle ..
  23. Glück S, Buttafuoco A, Meier A, Arnoldi F, Vogt B, Schraner E, et al. Rotavirus replication is correlated with S/G2 interphase arrest of the host cell cycle. PLoS ONE. 2017;12:e0179607 pubmed publisher
    ..We found that upon RV infection Eg5 kinesin was delocalized from the pericentriolar region to the viroplasms...
  24. Chen J, Rajasekaran M, Xia H, Zhang X, Kong S, Sekar K, et al. The microtubule-associated protein PRC1 promotes early recurrence of hepatocellular carcinoma in association with the Wnt/β-catenin signalling pathway. Gut. 2016;65:1522-34 pubmed publisher
    ..Thus, PRC1 controlled the expression and function of WRRAGs such as FANCI, SPC25, KIF11 and KIF23 via Wnt signalling...
  25. Kulkarni S, Goel Bhattacharya S, Sengupta S, Cochran B. A Large-Scale RNAi Screen Identifies SGK1 as a Key Survival Kinase for GBM Stem Cells. Mol Cancer Res. 2018;16:103-114 pubmed publisher
    ..In addition to identifying essential genes already implicated in GBM such as CDK4, KIF11, and RAN, the screen also identified new genes that have not been previously implicated in GBM stem ..
  26. Bell K, Cha H, Sindelar C, Cochran J. The yeast kinesin-5 Cin8 interacts with the microtubule in a noncanonical manner. J Biol Chem. 2017;292:14680-14694 pubmed publisher
    ..Competition assays with human kinesin-5 (Eg5) only partially abrogated this behavior, indicating that Cin8 binds microtubules not only at the canonical site, ..
  27. Kobayashi I, Ubukawa K, Sugawara K, Asanuma K, Guo Y, Yamashita J, et al. Erythroblast enucleation is a dynein-dependent process. Exp Hematol. 2016;44:247-56.e12 pubmed publisher
    ..We found that erythro-9-[3-(2-hydroxynonyl)]adenine (EHNA), a dynein inhibitor, and monastrol, a kinesin Eg5 inhibitor, as well as various inhibitors of MTOC regulators, including ON-01910 (Plk-1), MLN8237 (aurora A), ..
  28. Ferenz N, Wadsworth P. Prophase microtubule arrays undergo flux-like behavior in mammalian cells. Mol Biol Cell. 2007;18:3993-4002 pubmed
    ..at rates consistent with metaphase flux, is insensitive to inhibition of dynein but sensitive to perturbation of Eg5 and Kif2a, two proteins with previously documented roles in flux...
  29. Waraky A, Akopyan K, Parrow V, Strömberg T, Axelson M, Abrahmsén L, et al. Picropodophyllin causes mitotic arrest and catastrophe by depolymerizing microtubules via insulin-like growth factor-1 receptor-independent mechanism. Oncotarget. 2014;5:8379-92 pubmed
    ..resulting in a monopolar mitotic spindle with subsequent prometaphase-arrest, independent of Plk1/Aurora A or Eg5, and leading to cell features of mitotic catastrophe...
  30. Chen H, Li L, Chen X, Yang M, Ye Y, Wang X, et al. The mechanism of Jurkat cells apoptosis induced by Aggregatibacter actinomycetemcomitans cytolethal distending toxin. Apoptosis. 2017;22:841-851 pubmed publisher
    ..TNFRSF10B, UBE2I, ITM2A, CASP3, P53, EIF1, TCF3, HMGN5, CASP8) were up-regulated and 7 proteins (RRM2, TPX2, KIF11, NUCKS1, TOP2A, XRCC1, PTPLAD1, RRM2) were down-regulated, (vi) one possible apoptotic pathway [Ubc9 (UBE2I)/P53/..
  31. Gaba R, Groth J, Parvinian A, Guzman G, Casadaban L. Gene expression in hepatocellular carcinoma: pilot study of potential transarterial chemoembolization response biomarkers. J Vasc Interv Radiol. 2015;26:723-32 pubmed publisher
    ..1) greater (range, 1.49-3.50 fold) pretreatment chemotherapy-sensitivity and mitosis (ATF4, BAX, CCNE1, KIF11, NFX1, PPP3CA, SNX1, TOP2A, and TOP2B) gene mRNA expression compared with tumors with PR, in addition to lower ..
  32. Lee D, He D, Kessel E, Padari K, Kempter S, Lächelt U, et al. Tumoral gene silencing by receptor-targeted combinatorial siRNA polyplexes. J Control Release. 2016;244:280-291 pubmed publisher
    ..endocytosis, triggered significant eGFP-luciferase marker gene silencing, and transfection with antitumoral EG5 siRNA suppressed cell proliferation in FR-expressing tumor cells...
  33. Xu Z, Zhou Y, Cao Y, Dinh T, Wan J, Zhao M. Identification of candidate biomarkers and analysis of prognostic values in ovarian cancer by integrated bioinformatics analysis. Med Oncol. 2016;33:130 pubmed
    ..four genes of the 16 genes was associated with worse OS of patients with ovarian cancer, including CCNB1, CENPF, KIF11, and ZWINT. A significant module was detected from the PPI network...
  34. Pasiliao C, Chang C, Sutherland B, Valdez S, Schaeffer D, Yapp D, et al. The involvement of insulin-like growth factor 2 binding protein 3 (IMP3) in pancreatic cancer cell migration, invasion, and adhesion. BMC Cancer. 2015;15:266 pubmed publisher
    ..In addition, IMP3-depleted cells exhibited lower levels of CD44 protein and KIF11 mRNA...
  35. Akhtar J, Khan A, Ali Z, Haider R, Shahar Yar M. Structure-activity relationship (SAR) study and design strategies of nitrogen-containing heterocyclic moieties for their anticancer activities. Eur J Med Chem. 2017;125:143-189 pubmed publisher
    ..activities through multiple mechanisms including inhibiting protein kinase (CDK, MK-2, PLK1, kinesin-like protein Eg5 and IKK), topoisomerase I and II, microtubule inhibition, and many others...
  36. Klein P, Kern S, Lee D, Schmaus J, Höhn M, Gorges J, et al. Folate receptor-directed orthogonal click-functionalization of siRNA lipopolyplexes for tumor cell killing in vivo. Biomaterials. 2018;178:630-642 pubmed publisher
    ..administration of analogous therapeutic siRNA lipopolyplexes (directed against the kinesin spindle motor protein EG5) mediated tumoral EG5 mRNA knockdown by ?60% and, in combination with the novel antitubulin drug pretubulysin, ..
  37. Cochran J, Gatial J, Kapoor T, Gilbert S. Monastrol inhibition of the mitotic kinesin Eg5. J Biol Chem. 2005;280:12658-67 pubmed
    Monastrol is a small, cell-permeable molecule that arrests cells in mitosis by specifically inhibiting Eg5, a member of the Kinesin-5 family...
  38. Qian Y, Lu F, Dong M, Lin Y, Li H, Chen J, et al. Genetic variants of IDE-KIF11-HHEX at 10q23.33 associated with type 2 diabetes risk: a fine-mapping study in Chinese population. PLoS ONE. 2012;7:e35060 pubmed publisher
    ..33 containing IDE, KIF11 and HHEX genes (IDE-KIF11-HHEX), which has also been replicated in Chinese populations...
  39. McGrath M, Kuo I, Hayashi S, Takada S. Adenosine triphosphate hydrolysis mechanism in kinesin studied by combined quantum-mechanical/molecular-mechanical metadynamics simulations. J Am Chem Soc. 2013;135:8908-19 pubmed publisher
    ..Here, we study ATP hydrolysis mechanisms in the kinesin-5 protein Eg5 by using combined quantum mechanics/molecular mechanics metadynamics simulations...
  40. van Heesbeen R, Tanenbaum M, Medema R. Balanced activity of three mitotic motors is required for bipolar spindle assembly and chromosome segregation. Cell Rep. 2014;8:948-56 pubmed publisher
    ..Here, we show that three motor proteins, namely Eg5, Kif15, and dynein, act together to produce the right force balance in the spindle...
  41. Nalawansha D, Gomes I, Wambua M, Pflum M. HDAC Inhibitor-Induced Mitotic Arrest Is Mediated by Eg5/KIF11 Acetylation. Cell Chem Biol. 2017;24:481-492.e5 pubmed publisher
    ..Here, we identified mitosis-related protein Eg5 (KIF11) as an HDAC1 substrate using a trapping mutant strategy...
  42. Liu Y, Zhang Z, Liang H, Zhao X, Liang L, Wang G, et al. Protein Phosphatase 2A (PP2A) Regulates EG5 to Control Mitotic Progression. Sci Rep. 2017;7:1630 pubmed publisher
    EG5 (KIF11) is a member of the kinesin-like protein family involved in centrosome separation and bipolar spindle formation...
  43. Kaan H, Major J, Tkocz K, Kozielski F, Rosenfeld S. "Snapshots" of ispinesib-induced conformational changes in the mitotic kinesin Eg5. J Biol Chem. 2013;288:18588-98 pubmed publisher
    ..This loop is longest in the mitotic kinesin Eg5 and is the target for a number of small molecule inhibitors, including ispinesib, which is being used in clinical ..
  44. Liu L, Liu X, Mare M, Dumont A, Zhang H, Yan D, et al. Overexpression of Eg5 correlates with high grade astrocytic neoplasm. J Neurooncol. 2016;126:77-80 pubmed publisher
    To investigate the relationship between Eg5 and histopathological grade of astrocytoma, Eg5 expression was evaluated by immunohistochemical examination on 88 specimens including 25 cases of glioblastoma (WHO grade IV), 22 cases of ..
  45. Hu H, Xiao X, Li S, Jia X, Guo X, Zhang Q. KIF11 mutations are a common cause of autosomal dominant familial exudative vitreoretinopathy. Br J Ophthalmol. 2016;100:278-83 pubmed publisher
    To identify KIF11 mutations in patients with familial exudative vitreoretinopathy (FEVR) and to describe the associated phenotypes. Mutation analysis in a cohort of patients in a single institute was conducted...
  46. Gayek A, Ohi R. CDK-1 Inhibition in G2 Stabilizes Kinetochore-Microtubules in the following Mitosis. PLoS ONE. 2016;11:e0157491 pubmed publisher
    ..The essential bipolarity of the mitotic spindle is established by the kinesin-5 Eg5, but factors influencing the maintenance of spindle bipolarity are not fully understood...
  47. Sheth P, Basso A, Duca J, Lesburg C, Ogas P, Gray K, et al. Thermodynamics of nucleotide and inhibitor binding to wild-type and ispinesib-resistant forms of human kinesin spindle protein. Biochemistry. 2009;48:11045-55 pubmed publisher
    ..Among many innovations targeting specific mitotic events, inhibition of motor enzymes including KSP (or Eg5) has been validated as a highly productive approach...
  48. Wang G, Gao X, Huang Y, Yao Z, Shi Q, Wu M. Nucleophosmin/B23 inhibits Eg5-mediated microtubule depolymerization by inactivating its ATPase activity. J Biol Chem. 2010;285:19060-7 pubmed publisher
    ..Here, we report that B23 directly interacts with Eg5, a member of the kinesin family, in the cytosol...
  49. Tampoia M, Mastrandrea V, Cassano N, Vena G. Anti-NuMA antibodies in a psoriatic patient: considerations about clinical relevance and effect of infliximab treatment. Immunopharmacol Immunotoxicol. 2009;31:127-9 pubmed publisher
  50. Jones G, Ostergaard P, Moore A, Connell F, Williams D, Quarrell O, et al. Microcephaly with or without chorioretinopathy, lymphoedema, or mental retardation (MCLMR): review of phenotype associated with KIF11 mutations. Eur J Hum Genet. 2014;22:881-7 pubmed publisher
    ..Mutations in the kinesin family member 11 (KIF11) gene have now been described in 16 families worldwide...
  51. Al Obaidi N, Mitchison T, Crews C, Mayer T. Identification of MAC1: A Small Molecule That Rescues Spindle Bipolarity in Monastrol-Treated Cells. ACS Chem Biol. 2016;11:1544-51 pubmed publisher
    ..compounds that restore spindle bipolarity in cells treated with Monastrol, an inhibitor of the mitotic kinesin Eg5. We identified one compound-MAC1-that rescued spindle bipolarity in cells lacking Eg5 activity...
  52. Marques L, Semprebon S, Sartori D, de Fatima A, Ribeiro L, Mantovani M. Comparison of the Effects of Monastrol and Oxomonastrol on Human Hepatoma Cell Line HepG2/C3A. Anticancer Res. 2017;37:1197-1204 pubmed
    ..Monastrol inhibits the mitotic kinesin family member 11 (EG5), which has been studied for its potential use in cancer therapy...
  53. Eibes S, Gallisà Suñé N, Rosas Salvans M, Martínez Delgado P, Vernos I, Roig J. Nek9 Phosphorylation Defines a New Role for TPX2 in Eg5-Dependent Centrosome Separation before Nuclear Envelope Breakdown. Curr Biol. 2018;28:121-129.e4 pubmed publisher
    ..Prophase centrosome separation relies on the activity of Eg5/KIF11, a mitotic kinesin [9] that accumulates around centrosomes in early mitosis under the control of CDK1 and the Nek9/..
  54. Muretta J, Reddy B, Scarabelli G, Thompson A, Jariwala S, Major J, et al. A posttranslational modification of the mitotic kinesin Eg5 that enhances its mechanochemical coupling and alters its mitotic function. Proc Natl Acad Sci U S A. 2018;115:E1779-E1788 pubmed publisher
    ..We investigated one of these-acetylation of lysine 146 in Eg5-by creating an acetylation mimetic lysine to glutamine substitution (K146Q)...
  55. Ertekin Taner N, Allen M, Fadale D, Scanlin L, Younkin L, Petersen R, et al. Genetic variants in a haplotype block spanning IDE are significantly associated with plasma Abeta42 levels and risk for Alzheimer disease. Hum Mutat. 2004;23:334-42 pubmed
    ..64) with the six haplotypes in the 276-kb region spanning three genes (IDE, KNSL1, and HHEX) previously shown to associate with LOAD...
  56. Kim K, Xie Y, Tytler E, Woessner R, Mor G, Alvero A. KSP inhibitor ARRY-520 as a substitute for Paclitaxel in Type I ovarian cancer cells. J Transl Med. 2009;7:63 pubmed publisher
    ..However, unlike Paclitaxel, it does not induce these pro-tumor effects in Type I cells. Therefore, the KSP inhibitor ARRY-520 may represent an alternative to Paclitaxel in this subgroup of EOC patients. ..
  57. Parke C, Wojcik E, Kim S, Worthylake D. ATP hydrolysis in Eg5 kinesin involves a catalytic two-water mechanism. J Biol Chem. 2010;285:5859-67 pubmed publisher
    ..Coordination of switch movements via sequential proton transfer along paired water clusters may be universal for nucleotide triphosphatases with conserved active sites, such as myosins and G-proteins. ..
  58. Sahab Z, Hall M, Me Sung Y, Dakshanamurthy S, Ji Y, Kumar D, et al. Tumor suppressor RARRES1 interacts with cytoplasmic carboxypeptidase AGBL2 to regulate the α-tubulin tyrosination cycle. Cancer Res. 2011;71:1219-28 pubmed publisher
    ..We conclude that RARRES1, its interacting partners AGBL2, Eg5/KIF11, another EEY-bearing protein (EB1), and the microtubule tyrosination cycle are important in tumorigenesis and ..
  59. Peng D, Wang J, Zhang R, Jiang F, Tam C, Jiang G, et al. CDKAL1 rs7756992 is associated with diabetic retinopathy in a Chinese population with type 2 diabetes. Sci Rep. 2017;7:8812 pubmed publisher
    ..2 diabetes, and we found that ADAMTS9-AS2 rs4607103, WFS1 rs10010131, CDKAL1 rs7756992, VPS26A rs1802295 and IDE-KIF11-HHEX rs1111875 were significantly associated with DR...
  60. Daigo K, Takano A, Thang P, Yoshitake Y, Shinohara M, Tohnai I, et al. Characterization of KIF11 as a novel prognostic biomarker and therapeutic target for oral cancer. Int J Oncol. 2018;52:155-165 pubmed publisher
    ..Kinesin family member 11 (KIF11) is a motor protein required for establishing a bipolar spindle in cell division...
  61. Luo X, Shu M, Wang Y, Liu J, Yang W, Lin Z. 3D-QSAR studies of dihydropyrazole and dihydropyrrole derivatives as inhibitors of human mitotic kinesin Eg5 based on molecular docking. Molecules. 2012;17:2015-29 pubmed publisher
    Human mitotic kinesin Eg5 plays an essential role in mitoses and is an interesting drug target against cancer...
  62. Labrière C, Talapatra S, Thoret S, Bougeret C, Kozielski F, Guillou C. New MKLP-2 inhibitors in the paprotrain series: Design, synthesis and biological evaluations. Bioorg Med Chem. 2016;24:721-34 pubmed publisher
    ..The two most advanced kinesin targets are Eg5 and CENP-E with inhibitors in clinical trials...
  63. Cassimeris L, Morabito J. TOGp, the human homolog of XMAP215/Dis1, is required for centrosome integrity, spindle pole organization, and bipolar spindle assembly. Mol Biol Cell. 2004;15:1580-90 pubmed
    ..2003. Genes Dev. 17, 336-341). Eg5 motor activity was necessary to maintain the multipolar morphology...
  64. Garcia Saez I, DeBonis S, Lopez R, Trucco F, Rousseau B, Thuery P, et al. Structure of human Eg5 in complex with a new monastrol-based inhibitor bound in the R configuration. J Biol Chem. 2007;282:9740-7 pubmed
    Drugs that target mitotic spindle proteins have been proven useful for tackling tumor growth. Eg5, a kinesin-5 family member, represents a potential target, since its inhibition leads to prolonged mitotic arrest through the activation of ..
  65. Hayashi N, Koller E, Fazli L, Gleave M. Effects of Eg5 knockdown on human prostate cancer xenograft growth and chemosensitivity. Prostate. 2008;68:1283-95 pubmed publisher
    ..The Eg5 gene, a member of the kinesin-5 family, plays critical roles in proper mitotic spindle function, and is a potential ..
  66. Tsui M, Xie T, Orth J, Carpenter A, Rudnicki S, Kim S, et al. An intermittent live cell imaging screen for siRNA enhancers and suppressors of a kinesin-5 inhibitor. PLoS ONE. 2009;4:e7339 pubmed publisher
    Kinesin-5 (also known as Eg5, KSP and Kif11) is required for assembly of a bipolar mitotic spindle...
  67. Yin Y, Sun H, Xu J, Xiao F, Wang H, Yang Y, et al. Kinesin spindle protein inhibitor SB743921 induces mitotic arrest and apoptosis and overcomes imatinib resistance of chronic myeloid leukemia cells. Leuk Lymphoma. 2015;56:1813-20 pubmed publisher
    ..Furthermore, we demonstrated that SB743921 treatment suppressed ERK and AKT activity in CML cells. These data indicate that SB743921 may become a novel treatment agent for patients with CML. ..
  68. Balikova I, Robson A, Holder G, Ostergaard P, Mansour S, Moore A. Ocular manifestations of microcephaly with or without chorioretinopathy, lymphedema or intellectual disability (MCLID) syndrome associated with mutations in KIF11. Acta Ophthalmol. 2016;94:92-8 pubmed publisher
    ..Mutations in KIF11 have been found to be causative in approximately 75% of cases...
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    b>Eg5 is a motor protein belonging to the kinesin-5 family and has been suggested to exert important function in tumors...
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    ..the main biological property evaluated, since the main representative compound of this class (monastrol) is a known Eg5 kinesin inhibitor...
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    Mitotic kinesin Eg5 is a homotetrameric molecular motor that cross-links and slides microtubules. The extent to which Eg5 moves processively is not clear...
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    ..Mitosis-specific kinesin Eg5 represents an attractive anticancer target for discovering such new antimitotic agents, because Eg5 is essential ..
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    ..Thus, our data demonstrate a critical role for a methyl CpG binding protein in mediating DNA methylation-dependent repression and reveal the mechanism by which it represses transcription. ..
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    ..These data increase the present knowledge of genes responsible for the formation of the skin barrier and suggest new candidates for genodermatoses of unknown origin. ..
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    ..integrity, or modulation of the expression levels of molecules associated with spindle aberrations (Kif 1C, Kif 2A, Eg5, Tara, tankyrase-1, centractin, and TOGp)...
  76. Xu M, Gu Y, Barry J, Gu C. Kinesin I transports tetramerized Kv3 channels through the axon initial segment via direct binding. J Neurosci. 2010;30:15987-6001 pubmed publisher
    ..1 channels colocalize and comove with KIF5B along axons revealed by two-color time-lapse imaging. Our findings suggest that the binding to KIF5 ensures properly assembled and functioning Kv3.1 channels to be transported into axons. ..
  77. Sun L, Sun X, Xie S, Yu H, Zhong D. Significant decrease of ADP release rate underlies the potent activity of dimethylenastron to inhibit mitotic kinesin Eg5 and cancer cell proliferation. Biochem Biophys Res Commun. 2014;447:465-70 pubmed publisher
    b>Eg5 is a mitotic kinesin that plays a crucial role in the formation of bipolar mitotic spindles, by hydrolyzing ATP to push apart anti-parallel microtubules. Dimethylenastron is potent specific small molecule inhibitor of Eg5...
  78. Lu M, Zhu H, Wang X, Zhang D, Xiong L, Xu L, et al. The prognostic role of Eg5 expression in laryngeal squamous cell carcinoma. Pathology. 2016;48:214-8 pubmed publisher
    b>Eg5 is identified as a microtubule-dependent motor protein and has been suggested to play important role in cancer development...
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    ..We conducted in vitro assays using homotetrameric kinesin Eg5, a motor protein involved in the formation and maintenance of the mitotic spindle...
  80. Feizabadi M, Jun Y, Reddy J. Distinctions between dynamic characteristics of the single EG5 motor protein along neural vs. cancerous microtubules. Biochem Biophys Res Commun. 2016;478:1630-3 pubmed publisher
    ..breast cancer microtubules, we quantified the in vitro motility characteristics of single Eg5 molecular motors along these two types of microtubules, combining the utilization of an optical trapping technique ..
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    Spindle formation in mammalian cells requires precise spatial and temporal regulation of the kinesin-5, Eg5, which generates outward force to establish spindle bipolarity...
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    b>Eg5 (kinesin spindle protein) plays an essential role in mitosis. Inhibition of Eg5 function results in cell cycle arrest at mitosis, which leads to cell death...
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    ..Our results indicate that at least 12 kinesins are involved in mitosis and cytokinesis. Eg5 (a member of the kinesin-5 family), Kif2A (a member of the kinesin-13 family), and KifC1 (a member of the kinesin-..
  85. Krzysiak T, Grabe M, Gilbert S. Getting in sync with dimeric Eg5. Initiation and regulation of the processive run. J Biol Chem. 2008;283:2078-87 pubmed
    b>Eg5/KSP is the kinesin-related motor protein that generates the major plus-end directed force for mitotic spindle assembly and dynamics...
  86. Koppen A, Houtman R, Pijnenburg D, Jeninga E, Ruijtenbeek R, Kalkhoven E. Nuclear receptor-coregulator interaction profiling identifies TRIP3 as a novel peroxisome proliferator-activated receptor gamma cofactor. Mol Cell Proteomics. 2009;8:2212-26 pubmed publisher
    ..These findings indicate that NR-coregulator interaction profiling may be a useful tool for drug development and biological discovery. ..
  87. Zhao Y, Kull F, Cochran J. Modulation of the kinesin ATPase cycle by neck linker docking and microtubule binding. J Biol Chem. 2010;285:25213-20 pubmed publisher
    ..calorimetry and stopped-flow fluorometry to determine and analyze the thermodynamics of the human kinesin-5 (Eg5/KSP) ATPase cycle...
  88. Mortenson J, Heppler L, Banks C, Weerasekara V, Whited M, Piccolo S, et al. Histone deacetylase 6 (HDAC6) promotes the pro-survival activity of 14-3-3ζ via deacetylation of lysines within the 14-3-3ζ binding pocket. J Biol Chem. 2015;290:12487-96 pubmed publisher
    ..Furthermore, expression of the K49R/K120R mutant of 14-3-3ζ inhibits the cytotoxicity of HDAC6 inhibition. These data demonstrate a novel role for HDAC6 in controlling 14-3-3ζ binding activity. ..
  89. Pei Y, Li G, Ran J, Wei F. Kinesin family member 11 contributes to the progression and prognosis of human breast cancer. Oncol Lett. 2017;14:6618-6626 pubmed publisher
    The present study aimed to clarify the association between kinesin family member 11 (KIF11) and human breast cancer, and the effect of KIF11 on breast cancer cell progression...
  90. Maliga Z, Xing J, Cheung H, Juszczak L, Friedman J, Rosenfeld S. A pathway of structural changes produced by monastrol binding to Eg5. J Biol Chem. 2006;281:7977-82 pubmed
    Monastrol is a small molecule inhibitor that is specific for Eg5, a member of the kinesin 5 family of mitotic motors...
  91. Krzysiak T, Gilbert S. Dimeric Eg5 maintains processivity through alternating-site catalysis with rate-limiting ATP hydrolysis. J Biol Chem. 2006;281:39444-54 pubmed
    b>Eg5/KSP is a homotetrameric, Kinesin-5 family member whose ability to cross-link microtubules has associated it with mitotic spindle assembly and dynamics for chromosome segregation...
  92. Kalchishkova N, Böhm K. The role of Kinesin neck linker and neck in velocity regulation. J Mol Biol. 2008;382:127-35 pubmed publisher
    ..To elucidate the structural motifs contributing to velocity regulation, we expressed a set of Eg5- and KIF5A-based chimeric proteins with interchanged native neck linker and neck elements...