KDR

..In specific aim 3, we propose to examine the regulation of expression and function of the VEGF receptor KDR in amnion cells. The effects of VEGF on KDR mRNA and protein expression in the cells will be explored...

..high affinity receptors? Fms-like tyrosine kinase 1 (Flt-1)/vascular endothelial growth factor (VEGF) receptor 1 (VEGFR-1) and VEGF receptor-2 (=FLK-1/KDR or VEGFR-2)...

..explanted human allograft coronary vessels identified vascular endothelial growth factor receptor-2 (VEGFR2) and Neuropilin-2, both VEGF-responsive receptors, and endothelial/smooth muscle cell-derived neuropilin-like ..

..NRP-1 is a VEGF-165 specific receptor. It uses KDR-Flk-1 as a signaling co-receptor in endothelial cells, and plexin-A1 or L1-CAM in neuronal cells...

..We will compare responses initiated by different sets of VEGF receptors, VEGFR-2 and VEGFR-3, and we will utilize two VEGFs, VEGF-A165 and VEGF-D...

..b>Vascular endothelial growth factor receptor 2 (VEGFR2, Flk1 in mouse and KDR in men) is a key functional marker in embyronic ..

..New pharmacologic therapies to target VEGFR-2 (vascular endothelial growth factor receptor-2) are currently being developed for treatment of several human ..

..In a proteomic search for potential mediators of eNOS activation, we identified vascular endothelial growth factor receptor 2 (VEGFR2) as being involved in laminar flow-induced eNOS activation...

..in signaling proteins including certain kinases, integrins and vascular endothelial growth factor receptor-2 (VEGFR2), all of which are believed to play roles in angiogenesis...

..Single injections in mice of these adenoviruses produce high levels of circulating soluble Flk1 and Flt1 ectodomains which persist for >3-4 weeks, potently suppressing tumor growth and angiogenesis, and ..

..Single injections in mice of these adenoviruses produce high levels of circulating soluble Flk1 and Flt1 ectodomains which persist for >3-4 weeks, potently suppressing tumor growth and angiogenesis, and ..

..as a selective inhibitor of VEGF-A biologic activities down-regulating the principal VEGF-A signaling receptor, VEGFR-2 and co-receptor Npn-1...

..Cholangiocytes express the serotonin 1A and 1B, neurotrophin, and VEGF receptors, VEGFR-2 and VEGFR-3; 2. Cholangiocytes secrete serotonin, NGF and VEGF; 3...

..Targeting VEGF receptor (VEGFR) or disruption of VEGF signaling is believed to be a most promising strategy for the pharmacological therapy of ..

..VEGF acts upon two high affinity tyrosine kinase family receptors, Flt-1/ VEGFR-1 and Flk-1/ VEGFR-2...

..Cholangiocytes express the serotonin 1A and 1B, neurotrophin, and VEGF receptors, VEGFR-2 and VEGFR-3; 2. Cholangiocytes secrete serotonin, NGF and VEGF; 3...

..Very early in the premenstrual phase, one of the VEGF receptors, VEGFR-2, also known as KDR, was strongly expressed in the stromal cells (not the vascular endothelium) of the upper ..

..evidence that the effects of VEGF may not be restricted to endothelial cells is emerging, as VEGF receptors (VEGFR-1 and VEGFR-2) can be expressed by a subset of non-endothelial cell types...

..evidence that the effects of VEGF may not be restricted to endothelial cells is emerging, as VEGF receptors (VEGFR-1 and VEGFR-2) can be expressed by a subset of non-endothelial cell types...

..e., AT1A, TGF-beta type II receptor, and VEGFR-l/Flt-1, respectively)...

..e., AT1A, TGF-beta type II receptor, and VEGFR-l/Flt-1, respectively)...

..and maintenance of skin inflammation, (2) that VEGF-C promotes lymphangiogenesis predominantly via activation of VEGFR-3 whereas VEGF-induced lymphangiogenesis is mediated through activation of VEGFR-2 and through indirect effects ..

..searching for and developing new drugs to block retinal vascular leakage via targeting VEGF or the VEGF receptor (VEGFR) have become a major incentive and research effort for the treatment of DME...

..and maintenance of skin inflammation, (2) that VEGF-C promotes lymphangiogenesis predominantly via activation of VEGFR-3 whereas VEGF-induced lymphangiogenesis is mediated through activation of VEGFR-2 and through indirect effects ..

..searching for and developing new drugs to block retinal vascular leakage via targeting VEGF or the VEGF receptor (VEGFR) have become a major incentive and research effort for the treatment of DME...

..Recent results show that blockade of vascular endothelial growth factor receptor 2 (VEGFR2) transiently improves perivascular cell coverage, tissue oxygenation and response to ..

..the Notch signaling pathway in angiogenesis and the role that Notch target genes, specifically VEGF receptor-1 (VEGFR-1), play in the survival, sprouting, and proliferation of endothelial cells in response to angiogenic stimuli...

..This award will allow the candidate to develop into a well-trained independent researcher in PH...

..is a multicomponent complex comprising vascular endothelial (VE)-cadherin/ b-catenin,/VEGF-receptor 2 (Flk-1/KDR)/ phosphatidylinositol 3'(PI3)-kinase...

..protein SPARC/osteonectin constitutively interacts with VEGF-A and prevents it from activating VEGF receptor (VEGFR)-1...

..protein SPARC/osteonectin constitutively interacts with VEGF-A and prevents it from activating VEGF receptor (VEGFR)-1...

..the Notch signaling pathway in angiogenesis and the role that Notch target genes, specifically VEGF receptor-1 (VEGFR-1), play in the survival, sprouting, and proliferation of endothelial cells in response to angiogenic stimuli...

..In a proteomic search for potential mediators of eNOS activation, we identified vascular endothelial growth factor receptor 2 (VEGFR2) as being involved in laminar flow-induced eNOS activation...

..We hypothesize that the VEGFR-1 receptor in the podocyte was predominantly responsible for the manifestations of diabetic nephropathy that were ..

..Inhibiting VEGF receptor 2 (VEGFR2) activity with Sugen 1498 also blocks neuroprotection in these cells (unpublished data)...

..The broad objectives of this grant are to further define the nature and significance of Tat dependent oxidant signaling through Hic-5 and EG-1 in endothelial cells...

..The angiogenesis-inducing effects of VEGF are largely mediated via activation of the VEGF receptor-2 (VEGFR2) homodimer that can use the co-receptor, neuropilin 1...

..overall hypothesis is that caveolin-1 (cav-1) interacts with vascular endothelial growth factor (VEGF) receptors (VEGFR) directly and/or indirectly to concentrate VEGFR initiated signaling events, i.e...

..of ethanol (10-100mM) primed HBMEC for the upregulation of vascular endothelial growth factor receptor-2 (VEGFR2 or KDR), resulting in increased cytotoxicity, permeability and intracellular Ca2+ in response to Tat...

..Public Health Relevance: This Public Health Relevance is not available...

..These receptors are ideal targets for PID/PIT since they are often overexpressed and/or overactivated in many cancers, especially aggressive high-risk breast cancers...

..VEGF can bind to both VEGF-receptor-1 (VEGFR1) and VEGFR2, but much prior work indicates that VEGF stimulates angiogenesis primarily via VEGFR2...

..1) To determine the expression pattern of VEGF family members and their receptors (VEGFR1, VEGFR2, VEGFR3, and the neuropilins), and VEGF receptor activation status in the choroid-RPE complex during development ..

..The VEGF family of ligands (-A, -B, -C, -E, and PIGF) binds to three tyrosine kinase receptors (VEGFR-1, -2 and -3) that have been well characterized on endothelial cells...

..The VEGF family of ligands (-A, -B, -C, -E, and PIGF) binds to three tyrosine kinase receptors (VEGFR-1, -2 and -3) that have been well characterized on endothelial cells...

..that the specific VEGF receptors may govern whether VEGF stimulation is good or bad, in that stimulation of VEGFR-1 is expected to exacerbate renal vascular injury whereas stimulation of VEGFR-2 should accelerate capillary ..

..that the specific VEGF receptors may govern whether VEGF stimulation is good or bad, in that stimulation of VEGFR-1 is expected to exacerbate renal vascular injury whereas stimulation of VEGFR-2 should accelerate capillary ..

..studies of AMPK inhibition is Compound C, for example, which is more potent as an inhibitor of the VEGF receptor (KDR) than of AMPK...

..kinase receptors, fms-like tyrosine kinase (flt-1) and kinase insert domain-containing receptor/fetal liver kinase (KDR/flk-1), though it is not known if these receptors mediate its permeability-enhancing effects...

..adhesion resulting in enhanced microbubble retention to angiogenic endothelium expressing E- selectin and VEGFR-2...

..factor (VEGF), a potent proangiogenic factor, stimulates wound angiogenesis through the binding of its receptors VEGFR2 and neuropilin-1, which are expressed on the developing vasculature...

..directed towards a comprehensive analysis of the individual contributions of VEGF and the VEGF-receptors Flt1 and Flk1 for choroidal vascular functions, and towards exploring these signaling pathways as molecular targets for novel ..

..we plan to determine the mechanism by which the expression of Vascular Endothelial Growth Factor-receptors, VEGFR2 (Flk-1, KDR), VEGFR1 (Flt-1) and VEGFR3 (Flt-4) orchestrate proliferation, mobilization and incorporation of BM-..

..One of the central components of angiogenesis is the growth factor VEGF and its receptors VEGFR-1 and VEGFR-2...

..One of the central components of angiogenesis is the growth factor VEGF and its receptors VEGFR-1 and VEGFR-2...

..pulmonary vascular specification through differential accessibility and binding to VEGF receptors, VEGFR1 and VEGFR2. We propose that early in lung development the diffusible isoforms VEGF-A120 and VEGF-AI64 induce different signal ..

..heart disorder chemotherapy, heart revascularization, insulin, insulin sensitivity /resistance, myocardial ischemia /hypoxia behavioral /social science research tag, clinical research, health services research tag, human subject..

..The proposed investigations should provide important insight into mechanism of disease biology and the development of novel more effective therapeutics. Public Health Relevance: This Public Health Relevance is not available...

..The prototype VEGF binds VEGF receptor (VEGFR)-1 and VEGFR-2 and is angiogenic, whereas VEGF-C, which binds to VEGFR-2 and VEGFR-3, is either angiogenic or ..

..LYVE-1, and the vascular endothelial cell growth factor (VEGF)-C receptor, fms-like tyrosine kinase 4 (Flt-4)/VEGFR-3, were strongly expressed by expanded LECs, but not BECs. Conversely, BECs but not LECs expressed VEGF-C...

Vascular endothelial growth factor receptor (VEGFR) has recently been discovered on ovarian cancer cells, but its functional significance is unknown and is the focus of this study...

..factor (VEGF) and its receptor KDR (kinase insert domain-containing receptor/fetal liver kinase-1, also called VEGFR2) play critical roles in angiogenesis and vascular repair, which are involved in the progress of coronary heart ..

ZD6474 is a vascular endothelial growth factor receptor (VEGFR) and epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor...

..We determined that ureteric bud-derived cells express the main VEGF-A signaling receptor, VEGFR2 and RET, by RT-PCR, immunoblotting, and immunocytochemistry...

..We demonstrated that VEGF receptor KDR was expressed in ovarian cancer cells, and that CDDP-inhibited VEGF expression was linked with cellular apoptosis, ..

..Here we show that the monomeric extracellular domain of vascular endothelial growth factor (VEGF) receptor-2 (VEGFR-2) has a flexible structure...

..endothelial growth factor (VEGF), angiogenin, transforming growth factor-beta1 and VEGF receptors, VEGFR1 and VEGFR2, in human melanoma patients...

..In a previous study, we found that the association of vascular endothelial cadherin (VEC) with VEGF receptor (VEGFR) type 2 contributes to density-dependent growth inhibition (Lampugnani, G.M., A. Zanetti, M. Corada, T...

..we aimed to evaluate the immunolocalizations of vascular endothelial growth factor (VEGF), its receptors flt-1, KDR/flk-1, and transforming growth factor-beta's (TGF-beta) in epithelial ovarian tumors, utilizing indirect ..

Vascular endothelial growth factor receptor-2 (VEGFR2/KDR) is an important mediator of angiogenesis, and VEGFR2 mRNA is expressed in several pancreatic cancer cell lines...

..specifically associated with enhancement of VEGF expression, up-regulated and phosphorylated VEGF receptor-2 (KDR), and stimulated MMP-9 secretion. We investigated the signal pathway of IL-6/IL-6R responsible for KDR's regulation...

..and breast carcinoma cells expressing only NP-1 receptors for VEGF-A, but had no effect on binding to PAE/KDR or PAE/Flt-1...

..We identified a new CD34-/133+ EPC subpopulation, which is apparently a precursor of "classical" CD34+/133+ EPC, and functionally more potent than these with respect to homing and vascular repair...

..Our results suggest early separation of the two components of the primitive heart tube and imply Scl/Tal1 as an indispensable component of the molecular hierarchy that controls endocardium morphogenesis...

..factor (VEGF) induced C6 cell proliferation and migration, and SU1496, a selective inhibitor of VEGF receptor 2 (VEGFR2), blocked increased glioma cell growth, migration, and angiogenicity observed in AS-C6 cell cultures...

We revealed a significant positive correlation between the concentrations of tissue VEGF and its receptor VEGFR2 in the primary tumor...

..factor HIF1alpha, HIF2alpha, vascular endothelial growth factor (VEGF) and phosphorylated vascular endothelial growth factor receptor 2 (VEGFR2/KDR) expression...

..study (including 659 patients with SSc and 511 controls) using tag single-nucleotide polymorphisms on VEGFR1 and VEGFR2 genes...

..genes: hypoxia inducible factor-1 alpha (HIF1alpha), vascular endothelial growth factor (VEGF), VEGF-receptor 2 (VEGFR-2), endothelial nitric oxide synthase (eNOS), neuropilin-1 (NRP-1), and NRP-2...

..In conclusion, our study suggests that serum VEGF and VEGF-R1 may reflect the hepatic function impairment in liver cirrhosis and seems to be associated with portal hypertension symptoms...

..The ARPE19 human junctions in culture are modulated by VEGF through VEGFR-1 but not through VEGFR-2...

..The levels of VEGF and its receptors VEGFR-1 and VEGFR-2 were measured in the serum by quantitative sandwich enzyme immunoassay technique...

..Numbers of CD34+/kinase insert domain receptor (KDR)+ cells were determined by flow-cytometric analysis, either after magnetic separation of CD34+ cells (group 1) or ..

..This ultimately deprives VEGF receptors of an essential molecule required for promoting the disruption of endothelial cell-cell contacts and paracellular permeability...

..9). CONCLUSIONS: Preeclampsia and SGA are associated with low plasma concentrations of sVEGFR-2. One interpretation of the findings is that plasma sVEGFR-2 concentration could reflect endothelial cell function...

..VEGF-A(165), acting via VEGFR2/KDR, induced STC-1 through de novo transcription, mediated primarily via intracellular protein kinase C (PKC)- and ..

..on CAM was completely blocked by functional inhibition of VEGF receptor 2 kinase insert domain-containing receptor (KDR) and Rho GTPase...

..Real-time quantitative reverse-transcription polymerase chain reaction (RT-PCR) showed that VEGFR2 expression, contrary to VEGFR1 and VEGFR3 expression, was significantly higher on expanded EPCs than on freshly ..

..delphinidin inhibited vascular endothelial growth factor (VEGF)-induced tyrosine phosphorylation of VEGF receptor (VEGFR)-2, leading to the inhibition of downstream signaling triggered by VEGFR-2...

..We have shown that VEGF induces osteoclast differentiation through its action on VEGFR1. The way in which VEGF mediates its effect on mature osteoclast activity, however, may be through its interaction with both receptor subtypes...

..This effect is due to a potent inhibition of VEGFR2/KDR expression and promoter activity...

..Thus, vessel patterning during retinal angiogenesis depends on the balance between two different qualities of the extracellular VEGF-A distribution, which regulate distinct cellular responses in defined populations of endothelial cells...

..VEGF mediates its actions through activation of two receptor tyrosine kinases, VEGFR-1 and VEGFR-2...

..Activation of the receptor tyrosine kinase (RTK) Flk1 by vascular endothelial growth factor (VEGF) is crucial, but molecular interactions of other factors with VEGF and ..

..In the present study, we demonstrate that ADAMTS1 significantly blocks VEGFR2 phosphorylation with consequent suppression of endothelial cell proliferation...

..endothelial growth factor (VPF/VEGF) functions by activating two receptor-tyrosine kinases, Flt-1 (VEGF receptor (VEGFR)-1) and KDR (VEGFR-2), both of which are selectively expressed on primary vascular endothelium...

The stimulation of vascular endothelial growth factor receptor-2 (VEGFR-2) by tumor-derived VEGF represents a key event in the initiation of angiogenesis...

OBJECTIVE: This study evaluated the relative roles of the vascular endothelial growth factor (VEGF) receptors KDR and Flt-1 in the mediation of altered gene expression elicited by VEGF...

..Moreover, thrombin-induced phosphoinositide 3-kinase and mitogen-activated protein kinase activity were enhanced in the presence of VEGF...

Vascular endothelial growth factor (VEGF) receptors (VEGFR) play a major role in tumor angiogenesis and, thus, represent attractive targets for the development of novel anticancer therapeutics...

..in vivo expression of fibroblast growth factor receptors (FGFR) and vascular endothelial growth factor receptors (VEGFR) are not well understood...

..phosphorylated in response to VEGF in endothelial cells (HUVEC) and in 293 cells expressing the VEGF receptor KDR. An intact SH2 domain is required for Grb10 tyrosine phosphorylation in response to VEGF, and this phosphorylation ..

..VEGF(165) and VEGF(121) share similar affinities at the isolated VEGF receptor (VEGFR)-2 but have been previously demonstrated to have differential ability to activate VEGFR-2-mediated effects on ..

..Vascular endothelial growth factor receptors 1-3, also known as flt-1, KDR, and flt-4, are endothelial cell-specific receptor tyrosine kinases which serve as key mediators of the angiogenic ..

Expression of VEGF and VEGFR support a role for angiogenic pathways in the pathogenesis of some hematological malignances...

..The use of an anti-VEGF antibody and SU-1498, an inhibitor of VEGF receptor-2 (VEGFR-2 or flk/kdr) tyrosine kinase activity, demonstrated that these effects involve interactions between VEGF and ..

..delineate the degree of phosphorylated ERK1/2 in breast cancer and potential links to upstream receptors such as VEGFR2, ErbB2, downstream targets, such as Ets-2, as well as clinico-pathological parameters, clinical outcome and ..

Vascular endothelial growth factor (VEGF) and vascular endothelial growth factor receptor-2 (VEGFR-2) play a key role in vasculogenesis and angiogenic sprouting, which are crucial for tumour development and metastasis...

..These results suggest that the expression of PU.1 is a critical event for osteoclastogenesis and that Tal-1 may lie upstream of PU.1 in a regulatory hierarchy during osteoclastogenesis...

..of focal adhesion kinase (FAK) on site Tyr(407), an effect that required the association of VEGF receptor 2 (VEGFR2) with HSP90...

..The sequential expression of growth factors in different cell types may point to the fact that placental vasculogenesis and angiogenesis are clearly distinct events...

..was found to derive in part from the up-regulation of the vascular endothelial growth factor receptor Flk-1/KDR by endothelial cells through an integrin alpha(v)beta(3)-focal adhesion kinase-mediated signaling pathway...

..In this study, we show that Grb10 acts as a positive regulator in VEGF-R2 signaling and protects VEGF-R2 from degradation by interacting with Nedd4, a component of the endocytic machinery...

..hematopoietic stem cell survival via an internal loop, the molecular mechanisms whereby autocrine stimulation of VEGFR-2 (KDR) promotes leukemia growth are not well understood...

To clarify the role of caveolae in VEGF/VEGF receptor-2 (VEGFR-2)-mediated signaling cascades, primary cultured human umbilical vein endothelial cells (HUVECs) were fractionated to isolate caveolae-enriched cell membranes...

..05). CONCLUSION: Changing intensification of transcriptional activity of VEGF gene and its receptors indicates on autocrine mechanism regulation of angiogenic genes activity in the first steep of carcinogenesis--LSIL...

..Analyses of VEGF-D receptor specificity revealed that VEGF-D is a ligand for both VEGF receptors (VEGFRs) VEGFR-2 (Flk1) and VEGFR-3 (Flt4) and can activate these receptors. However. VEGF-D does not bind to VEGFR-1...

..In order to define signaling pathways downstream of VEGF receptors (VEGFR), the kinase domain of VEGFR2 (Flk-1) was used as a bait to screen a human fetal heart library in the yeast two-hybrid system...

..between beta3 integrin and tyrosine kinase receptor 2 for vascular endothelial growth factor (VEGF) receptor (VEGFR-2) on endothelium...