Gene Symbol: KDM7A
Description: lysine demethylase 7A
Alias: JHDM1D, lysine-specific demethylase 7A, histone lysine demethylase JHDM1D, jmjC domain-containing histone demethylation protein 1D, jumonji C domain containing histone demethylase 1 homolog D, lysine (K)-specific demethylase 7A, lysine-specific demethylase 7
Species: human
Products:     KDM7A

Top Publications

  1. Horton J, Upadhyay A, Qi H, Zhang X, Shi Y, Cheng X. Enzymatic and structural insights for substrate specificity of a family of jumonji histone lysine demethylases. Nat Struct Mol Biol. 2010;17:38-43 pubmed publisher
    ..repressive marks, is differentially 'read' by two related human demethylases, PHF8 and KIAA1718 (also known as JHDM1D)...
  2. Sase H, Nakanishi Y, Aida S, Horiguchi Takei K, Akiyama N, Fujii T, et al. Acquired JHDM1D-BRAF Fusion Confers Resistance to FGFR Inhibition in FGFR2-Amplified Gastric Cancer. Mol Cancer Ther. 2018;17:2217-2225 pubmed publisher
    ..The chromosomal breakpoints were located between the 12th and the 13th exon of jumonji C domain containing histone demethylase 1 homolog D (JHDM1D) and between the 3rd and the 4th exon of BRAF We sequenced cDNA ..
  3. McMichael G, Bainbridge M, Haan E, Corbett M, Gardner A, Thompson S, et al. Whole-exome sequencing points to considerable genetic heterogeneity of cerebral palsy. Mol Psychiatry. 2015;20:176-82 pubmed publisher
    ..identified disease genes (TUBA1A (n=2), SCN8A (n=1) and KDM5C (n=1)) and in six novel candidate CP genes (AGAP1, JHDM1D, MAST1, NAA35, RFX2 and WIPI2) were predicted to be potentially pathogenic for CP...
  4. Luo S, Pei J, Li X, Gu W. Decreased expression of JHDMID in placenta is associated with preeclampsia through HLA-G. J Hum Hypertens. 2018;32:448-454 pubmed publisher
    ..So we aimed to confirm that abnormal expression of histone demethylase JHDM1D contributes to PE and lower expression of HLA-G in PE...
  5. Nawrocki M, Strugała A, Piotrowski P, Wudarski M, Olesińska M, Jagodziński P. JHDM1D and HDAC1-3 mRNA expression levels in peripheral blood mononuclear cells of patients with systemic lupus erythematosus. Z Rheumatol. 2015;74:902-10 pubmed publisher
    ..We studied the histone demethylase JHDM1D and histone deacetylases HDAC1, HDAC2, and HDAC3 transcript levels in peripheral blood mononuclear cells (PBMCs) ..
  6. Kondo A, Nonaka A, Shimamura T, Yamamoto S, Yoshida T, Kodama T, et al. Long Noncoding RNA JHDM1D-AS1 Promotes Tumor Growth by Regulating Angiogenesis in Response to Nutrient Starvation. Mol Cell Biol. 2017;37: pubmed publisher
    ..Here, we show that a nutrient starvation-responsive long noncoding RNA, JHDM1D antisense 1 (JHDM1D-AS1), promotes tumorigenesis by regulating angiogenesis in response to nutrient starvation...
  7. Xie G, Liu X, Zhang Y, Li W, Liu S, Chen Z, et al. UTX promotes hormonally responsive breast carcinogenesis through feed-forward transcription regulation with estrogen receptor. Oncogene. 2017;36:5497-5511 pubmed publisher
    ..We showed that UTX coordinates with JHDM1D and CBP to direct H3K27 methylation-acetylation transition and to create a permissive chromatin state on ER ..
  8. Nilsson E, Laursen K, Whitchurch J, McWilliam A, Ødum N, Persson J, et al. MiR137 is an androgen regulated repressor of an extended network of transcriptional coregulators. Oncotarget. 2015;6:35710-25 pubmed publisher
    ..coregulators including KDM1A/LSD1/AOF1, KDM2A/JHDM1A/FBXL11, KDM4A/JMJD2A, KDM5B JARID1B/PLU1, KDM7A/JHDM1D/PHF8, MED1/TRAP220/DRIP205 and NCoA2/SRC2/TIF2...
  9. Tsukada Y, Ishitani T, Nakayama K. KDM7 is a dual demethylase for histone H3 Lys 9 and Lys 27 and functions in brain development. Genes Dev. 2010;24:432-7 pubmed publisher
    ..Our findings identify KDM7 as a dual demethylase for H3K9 and H3K27 that functions as an eraser of silencing marks on chromatin during brain development...

More Information


  1. Pan M, Hsu M, Chen L, Hung W. G9a orchestrates PCL3 and KDM7A to promote histone H3K27 methylation. Sci Rep. 2015;5:18709 pubmed publisher
    ..promoter by upregulating PCL3 to increase PRC2 promoter recruitment and by downregulating the H3K27 demethylase KDM7A to silence E-cadherin gene...
  2. Huang C, Xiang Y, Wang Y, Li X, Xu L, Zhu Z, et al. Dual-specificity histone demethylase KIAA1718 (KDM7A) regulates neural differentiation through FGF4. Cell Res. 2010;20:154-65 pubmed publisher
    ..Here, we identified KIAA1718 (KDM7A) as a novel histone demethylase specific for these two repressing marks...
  3. Choi J, Jo S. KDM7A histone demethylase mediates TNF-?-induced ICAM1 protein upregulation by modulating lysosomal activity. Biochem Biophys Res Commun. 2016;478:1355-62 pubmed publisher
    ..TNF-? also upregulated histone demethylases KDM1B and KDM7A responsible for demethylation of H3K9me2, a well-known repression marker...
  4. Qi H, Sarkissian M, Hu G, Wang Z, Bhattacharjee A, Gordon D, et al. Histone H4K20/H3K9 demethylase PHF8 regulates zebrafish brain and craniofacial development. Nature. 2010;466:503-7 pubmed publisher
    ..Our findings indicate that an imbalance of histone methylation dynamics has a critical role in XLMR. ..
  5. Osawa T, Muramatsu M, Wang F, Tsuchida R, Kodama T, Minami T, et al. Increased expression of histone demethylase JHDM1D under nutrient starvation suppresses tumor growth via down-regulating angiogenesis. Proc Natl Acad Sci U S A. 2011;108:20725-9 pubmed publisher
    Histone demethylase JHDM1D (also known as KDM7A) modifies the level of methylation in histone and participates in epigenetic gene regulation; however, the role of JHDM1D in tumor progression is unknown...
  6. Guo T, Chung J, Wang T, McDonald McGinn D, Kates W, Hawuła W, et al. Histone Modifier Genes Alter Conotruncal Heart Phenotypes in 22q11.2 Deletion Syndrome. Am J Hum Genet. 2015;97:869-77 pubmed publisher
    ..Eighteen case subjects (20%) had rdSNVs in four genes (JMJD1C, RREB1, MINA, KDM7A) all involved in demethylation of histones (H3K9, H3K27)...