KDM6A

Summary

Gene Symbol: KDM6A
Description: lysine demethylase 6A
Alias: KABUK2, UTX, bA386N14.2, lysine-specific demethylase 6A, bA386N14.2 (ubiquitously transcribed X chromosome tetratricopeptide repeat protein (UTX)), histone demethylase UTX, lysine (K)-specific demethylase 6A, ubiquitously transcribed tetratricopeptide repeat protein X-linked, ubiquitously-transcribed TPR gene on the X chromosome
Species: human
Products:     KDM6A

Top Publications

  1. Greenfield A, Carrel L, Pennisi D, Philippe C, Quaderi N, Siggers P, et al. The UTX gene escapes X inactivation in mice and humans. Hum Mol Genet. 1998;7:737-42 pubmed
    ..Here we report the characterization of a widely transcribed X-linked homologue of Uty , called Utx , which maps to the proximal region of the mouse X chromosome and which detects a human X-linked homologue at Xp11...
  2. Issaeva I, Zonis Y, Rozovskaia T, Orlovsky K, Croce C, Nakamura T, et al. Knockdown of ALR (MLL2) reveals ALR target genes and leads to alterations in cell adhesion and growth. Mol Cell Biol. 2007;27:1889-903 pubmed
    ..shared with other SET1 family complexes and several unique components, such as PTIP and the jumonji family member UTX. Like other complexes formed by SET1 family members, the ALR complex exhibited strong H3K4 methyltransferase ..
  3. Agger K, Cloos P, Christensen J, Pasini D, Rose S, Rappsilber J, et al. UTX and JMJD3 are histone H3K27 demethylases involved in HOX gene regulation and development. Nature. 2007;449:731-4 pubmed
    ..Here we show that the human JmjC-domain-containing proteins UTX and JMJD3 demethylate tri-methylated Lys 27 on histone H3...
  4. Lee M, Villa R, Trojer P, Norman J, Yan K, Reinberg D, et al. Demethylation of H3K27 regulates polycomb recruitment and H2A ubiquitination. Science. 2007;318:447-50 pubmed
    ..Here we show that human UTX, a member of the Jumonji C family of proteins, is a di- and trimethyl H3K27 demethylase...
  5. Lan F, Bayliss P, Rinn J, Whetstine J, Wang J, Chen S, et al. A histone H3 lysine 27 demethylase regulates animal posterior development. Nature. 2007;449:689-94 pubmed
    ..Here we show that the JmjC-domain-containing related proteins UTX and JMJD3 catalyse demethylation of H3K27me3/2...
  6. Hong S, Cho Y, Yu L, Yu H, Veenstra T, Ge K. Identification of JmjC domain-containing UTX and JMJD3 as histone H3 lysine 27 demethylases. Proc Natl Acad Sci U S A. 2007;104:18439-44 pubmed
    ..Here we show the JmjC domain-containing protein UTX (ubiquitously transcribed tetratricopeptide repeat, X chromosome), as well as the related JMJD3 (jumonji domain ..
  7. van Haaften G, Dalgliesh G, Davies H, Chen L, Bignell G, Greenman C, et al. Somatic mutations of the histone H3K27 demethylase gene UTX in human cancer. Nat Genet. 2009;41:521-3 pubmed publisher
    ..Here, we describe inactivating somatic mutations in the histone lysine demethylase gene UTX, pointing to histone H3 lysine methylation deregulation in multiple tumor types...
  8. Lee S, Lee J, Lee S. UTX, a histone H3-lysine 27 demethylase, acts as a critical switch to activate the cardiac developmental program. Dev Cell. 2012;22:25-37 pubmed publisher
    ..Here we show that UTX, a H3K27 demethylase, acts as a critical switch to promote a cardiac-specific gene program...
  9. Mansour A, Gafni O, Weinberger L, Zviran A, Ayyash M, Rais Y, et al. The H3K27 demethylase Utx regulates somatic and germ cell epigenetic reprogramming. Nature. 2012;488:409-13 pubmed publisher
    ..Here we show in mice and humans that the histone H3 methylated Lys?27 (H3K27) demethylase Utx (also known as Kdm6a) regulates the efficient induction, rather than maintenance, of pluripotency...

More Information

Publications113 found, 100 shown here

  1. Shahhoseini M, Taghizadeh Z, Hatami M, Baharvand H. Retinoic acid dependent histone 3 demethylation of the clustered HOX genes during neural differentiation of human embryonic stem cells. Biochem Cell Biol. 2013;91:116-22 pubmed publisher
    ..decrease in methylation of histone H3K27 parallel to an absolute preferential incorporation of the demethylase UTX rather than JMJD3 in RA-induced neural differentiated cells...
  2. Dalgliesh G, Furge K, Greenman C, Chen L, Bignell G, Butler A, et al. Systematic sequencing of renal carcinoma reveals inactivation of histone modifying genes. Nature. 2010;463:360-3 pubmed publisher
    ..known as KDM5C), a histone H3 lysine 4 demethylase-as well as mutations in the histone H3 lysine 27 demethylase, UTX (KMD6A), that we recently reported...
  3. Sengoku T, Yokoyama S. Structural basis for histone H3 Lys 27 demethylation by UTX/KDM6A. Genes Dev. 2011;25:2266-77 pubmed publisher
    ..Here we report the crystal structures of the catalytic fragment of UTX/KDM6A, an H3K27me3/2-specific demethylase, in the free and H3 peptide-bound forms...
  4. Li F, Wu R, Cui X, Zha L, Yu L, Shi H, et al. Histone Deacetylase 1 (HDAC1) Negatively Regulates Thermogenic Program in Brown Adipocytes via Coordinated Regulation of Histone H3 Lysine 27 (H3K27) Deacetylation and Methylation. J Biol Chem. 2016;291:4523-36 pubmed publisher
    ..concomitant recruitment of H3K27 demethylase ubiquitously transcribed tetratricopeptide repeat on chromosome X (UTX) to) Ucp1 and Pgc1α promoters, leading to decreased H3K27 trimethylation, a histone transcriptional repression ..
  5. Bando T, Mito T, Hamada Y, Ishimaru Y, Noji S, Ohuchi H. Molecular mechanisms of limb regeneration: insights from regenerating legs of the cricket Gryllus bimaculatus. Int J Dev Biol. 2018;62:559-569 pubmed publisher
    ..Availability of whole-genome sequence information, regeneration-dependent RNA interference, and genome editing technique will have the cricket be an ideal model system to reveal gene functions in leg regeneration. ..
  6. Borensztein M, Okamoto I, Syx L, Guilbaud G, Picard C, Ancelin K, et al. Contribution of epigenetic landscapes and transcription factors to X-chromosome reactivation in the inner cell mass. Nat Commun. 2017;8:1297 pubmed publisher
    ..We further show that in UTX H3K27 histone demethylase mutant embryos, these genes are even more slowly reactivated, suggesting that these genes ..
  7. Rosales W, Carulla J, Garcia J, Vargas D, Lizcano F. Role of Histone Demethylases in Cardiomyocytes Induced to Hypertrophy. Biomed Res Int. 2016;2016:2634976 pubmed
    ..A significant increase in JMJD2A expression, but not in UTX or JMJD2C expression, was observed...
  8. Peneder P, Wallner B, Vogl C. Exchange of genetic information between therian X and Y chromosome gametologs in old evolutionary strata. Ecol Evol. 2017;7:8478-8487 pubmed publisher
    ..of genes from cattle, mice, and humans identified four genes, DDX3X/Y,RBMX/Y,USP9X/Y, and UTX/Y, exhibiting a preradiation topology...
  9. Xu B, Konze K, Jin J, Wang G. Targeting EZH2 and PRC2 dependence as novel anticancer therapy. Exp Hematol. 2015;43:698-712 pubmed publisher
    ..by genetic events observed in various hematologic cancers, such as inactivation of SNF5 and somatic mutation of UTX, confers PRC2 dependence, thus rendering an increased sensitivity to PRC2 inhibition...
  10. Shishido Y, Baba T, Sato T, Shima Y, Miyabayashi K, Inoue M, et al. Differential lactate and cholesterol synthetic activities in XY and XX Sertoli cells. Sci Rep. 2017;7:41912 pubmed publisher
    ..at least in part by the differential expression of histone modification enzymes SMCX/SMCY (H3K4me3 demethylase) and UTX/UTY (H3K27me3 demethylase) encoded by the sex chromosomes...
  11. Park U, Kang M, Kim E, Kwon Y, Hur W, Yoon S, et al. ASXL2 promotes proliferation of breast cancer cells by linking ERα to histone methylation. Oncogene. 2016;35:3742-52 pubmed publisher
    ..ASXL2 forms a complex with histone methylation modifiers including LSD1, UTX and MLL2, which all are recruited to the E2-responsive genes via ASXL2 and regulate methylations at histone H3 ..
  12. Sadasivam D, Huang D. Feedback regulation by antagonistic epigenetic factors potentially maintains developmental homeostasis in Drosophila. J Cell Sci. 2018;131: pubmed publisher
    ..Concomitantly, the global H3K27me3 level is markedly reduced, corresponding to an increase in the amount of Utx demethylase...
  13. Macedo L, Silvestre A, Rodrigues C, de Alencar J, Zacarias J, Ambrosio Albuquerque E, et al. Genetics factors associated with myelodysplastic syndromes. Blood Cells Mol Dis. 2015;55:76-81 pubmed publisher
    ..The recent recognition that genes involved in the regulation of histone function (EZH2, ASXL1, and UTX) and DNA methylation (DNMT3A, IDH1/IDH2, and TET2) are frequently mutated in MDS, has led to the proposal that ..
  14. Rojas A, Aguilar R, Henriquez B, Lian J, Stein J, Stein G, et al. Epigenetic Control of the Bone-master Runx2 Gene during Osteoblast-lineage Commitment by the Histone Demethylase JARID1B/KDM5B. J Biol Chem. 2015;290:28329-42 pubmed publisher
    ..Importantly, knockdown of the H3K4me2/3 demethylase JARID1B, but not of the demethylases UTX and NO66, prevents repression of the Runx2 P1 promoter during myogenic differentiation of mesenchymal cells...
  15. Wu R, Nie Q, Tapper E, Jerde C, Dunlap G, Shrestha S, et al. Histone H3K27 Trimethylation Modulates 5-Fluorouracil Resistance by Inhibiting PU.1 Binding to the DPYD Promoter. Cancer Res. 2016;76:6362-6373 pubmed
    ..Here, we report that H3K27 trimethylation (H3K27me3) at the DPYD promoter regulated by Ezh2 and UTX suppresses DPYD expression by inhibiting transcription factor PU.1 binding, leading to increased resistance to 5-FU...
  16. Fontcuberta PiSunyer M, Cervantes S, Miquel E, Mora Castilla S, Laurent L, Raya A, et al. Modulation of the endocrine transcriptional program by targeting histone modifiers of the H3K27me3 mark. Biochim Biophys Acta Gene Regul Mech. 2018;1861:473-480 pubmed publisher
    ..Our data show that chemical inhibition of the H3K27me3 demethylases Jmjd3/Utx blunts Neurogenin3-dependent gene activation in vitro...
  17. Chaturvedi C, Somasundaram B, Singh K, Carpenedo R, Stanford W, Dilworth F, et al. Maintenance of gene silencing by the coordinate action of the H3K9 methyltransferase G9a/KMT1C and the H3K4 demethylase Jarid1a/KDM5A. Proc Natl Acad Sci U S A. 2012;109:18845-50 pubmed publisher
    ..Taken together with our previous demonstration of cross-talk between UTX and MLL2 to mediate activation of the adult β(maj)-globin gene, these data suggest a model where "active" and "..
  18. Wang X, Dostie J. Reciprocal regulation of chromatin state and architecture by HOTAIRM1 contributes to temporal collinear HOXA gene activation. Nucleic Acids Res. 2017;45:1091-1104 pubmed publisher
    ..to physical dissociation of chromatin loops at the cluster proximal end, which delays recruitment of the histone demethylase UTX and transcription of central HOXA genes...
  19. Dutta A, Le Magnen C, Mitrofanova A, Ouyang X, Califano A, Abate Shen C. Identification of an NKX3.1-G9a-UTY transcriptional regulatory network that controls prostate differentiation. Science. 2016;352:1576-80 pubmed publisher
    ..homeodomain and are mediated by activation of target genes such as UTY (KDM6c), the male-specific paralog of UTX (KDM6a) We propose that an NKX3...
  20. He X, Chen X, Zhang X, Duan X, Pan T, Hu Q, et al. An Lnc RNA (GAS5)/SnoRNA-derived piRNA induces activation of TRAIL gene by site-specifically recruiting MLL/COMPASS-like complexes. Nucleic Acids Res. 2015;43:3712-25 pubmed publisher
    ..WDR5, resulting in a site-specific recruitment of the hCOMPASS-like complexes containing at least MLL3 and UTX (KDM6A). We have indicated a novel pathway for piRNAs to specially activate gene expression...
  21. Hori H, Nazumi Y, Uto Y. Boron tracedrug design for neutron dynamic therapeutics for LDL. Adv Exp Med Biol. 2013;789:385-389 pubmed publisher
    ..Thus, we examined, among our developed boron tracedrugs, a boron-containing curcuminoid derivative UTX-51, to destroy freshly isolated human LDL dynamically under irradiated thermal neutron to obtain a decreased ..
  22. Brannstrom M, Dahm Kähler P. Uterus transplantation and fertility preservation. Best Pract Res Clin Obstet Gynaecol. 2019;55:109-116 pubmed publisher
    ..summarises the research preparations that paved the way for the clinical introduction of uterus transplantation (UTx) as a treatment for AUFI...
  23. Chakraborty A, Laukka T, Myllykoski M, Ringel A, Booker M, Tolstorukov M, et al. Histone demethylase KDM6A directly senses oxygen to control chromatin and cell fate. Science. 2019;363:1217-1222 pubmed publisher
    ..We found that the H3K27 histone demethylase KDM6A/UTX, but not its paralog KDM6B, is oxygen sensitive...
  24. Nguyen H, Sokpor G, Pham L, Rosenbusch J, Stoykova A, Staiger J, et al. Epigenetic regulation by BAF (mSWI/SNF) chromatin remodeling complexes is indispensable for embryonic development. Cell Cycle. 2016;15:1317-24 pubmed publisher
    ..heterochromatin marks, H3K27me2 and -3, by directly modulating the enzymatic activity of the H3K27 demethylases, Utx and Jmjd3...
  25. Gale M, Sayegh J, Cao J, Norcia M, Gareiss P, Hoyer D, et al. Screen-identified selective inhibitor of lysine demethylase 5A blocks cancer cell growth and drug resistance. Oncotarget. 2016;7:39931-39944 pubmed publisher
    ..great specificity and did not inhibit its close homologue KDM5B (PLU1/JARID1B) or the related H3K27 demethylases KDM6A (UTX) and KDM6B (JMJD3)...
  26. Kushwaha R, Jagadish N, Kustagi M, Mendiratta G, Seandel M, Soni R, et al. Mechanism and Role of SOX2 Repression in Seminoma: Relevance to Human Germline Specification. Stem Cell Reports. 2016;6:772-783 pubmed publisher
    ..SOX2 repression in TCam-2 cells can be abrogated by recruitment of the constitutively expressed H3K27 demethylase UTX to the SOX2 promoter through retinoid signaling, leading to expression of neuronal and other lineage genes...
  27. Pawlyn C, Kaiser M, Heuck C, Melchor L, Wardell C, Murison A, et al. The Spectrum and Clinical Impact of Epigenetic Modifier Mutations in Myeloma. Clin Cancer Res. 2016;22:5783-5794 pubmed
    ..impact from the presence of lesions in genes encoding DNA methylation modifiers and the histone demethylase KDM6A/UTX The frequency of mutations in epigenetic modifiers appears to increase following treatment most notably in ..
  28. Petruk S, Mariani S, De Dominici M, Porazzi P, Minieri V, Cai J, et al. Structure of Nascent Chromatin Is Essential for Hematopoietic Lineage Specification. Cell Rep. 2017;19:295-306 pubmed publisher
    ..to a significant delay in accumulation of H3K27me3 in nascent chromatin due to activity of the H3K27me3 demethylase UTX. Thus, HPCs utilize special mechanisms of chromatin modification for recruitment of specific TFs to DNA during ..
  29. Seelk S, Adrian Kalchhauser I, Hargitai B, Hajduskova M, Gutnik S, Tursun B, et al. Increasing Notch signaling antagonizes PRC2-mediated silencing to promote reprograming of germ cells into neurons. elife. 2016;5: pubmed publisher
    ..specific genes, silenced by the Polycomb repressive complex 2 (PRC2), and identify the conserved histone demethylase UTX-1 as a crucial GLP-1/Notch target facilitating reprograming...
  30. Narayanan R, Pirouz M, Kerimoglu C, Pham L, Wagener R, Kiszka K, et al. Loss of BAF (mSWI/SNF) Complexes Causes Global Transcriptional and Chromatin State Changes in Forebrain Development. Cell Rep. 2015;13:1842-54 pubmed publisher
    ..We demonstrate that BAF complexes interact with H3K27 demethylases (JMJD3 and UTX) and potentiate their activity...
  31. Wang L, Zhao Z, Ozark P, Fantini D, Marshall S, Rendleman E, et al. Resetting the epigenetic balance of Polycomb and COMPASS function at enhancers for cancer therapy. Nat Med. 2018;24:758-769 pubmed publisher
    ..that had PHD-associated MLL3 mutations or lacked BAP1 showed reduced recruitment of MLL3 and the H3K27 demethylase KDM6A (also known as UTX) to gene enhancers...
  32. Giaimo B, Oswald F, Borggrefe T. Dynamic chromatin regulation at Notch target genes. Transcription. 2017;8:61-66 pubmed publisher
    ..Here, we discuss the molecular mechanisms how RBPJ interacts with opposing NCoR/HDAC-corepressing or KMT2D/UTX-coactivating complexes and how this is controlled by phosphorylation of chromatin modifiers.
  33. Cribbs A, Hookway E, Wells G, Lindow M, Obad S, Oerum H, et al. Inhibition of histone H3K27 demethylases selectively modulates inflammatory phenotypes of natural killer cells. J Biol Chem. 2018;293:2422-2437 pubmed publisher
    ..The prototypic JMJD3/UTX (Jumonji domain-containing protein 3) H3K27 demethylase inhibitor GSK-J4 increased global levels of the repressive ..
  34. Lee J, Saha P, Yang Q, Lee S, Park J, Suh Y, et al. Targeted inactivation of MLL3 histone H3-Lys-4 methyltransferase activity in the mouse reveals vital roles for MLL3 in adipogenesis. Proc Natl Acad Sci U S A. 2008;105:19229-34 pubmed publisher
    ..These results suggest that ASCOM-MLL3 and ASCOM-MLL4 likely function as crucial but redundant H3K4MT complexes for PPARgamma-dependent adipogenesis. ..
  35. Burchfield J, Li Q, Wang H, Wang R. JMJD3 as an epigenetic regulator in development and disease. Int J Biochem Cell Biol. 2015;67:148-57 pubmed publisher
    ..containing-3 (Jmjd3, KDM6B) and ubiquitously transcribed X-chromosome tetratricopeptide repeat protein (UTX, KDM6A) have been identified as H3K27 demethylases that catalyze the demethylation of H3K27me2/3...
  36. Xie B, Zhang H, Wei R, Li Q, Weng X, Kong Q, et al. Histone H3 lysine 27 trimethylation acts as an epigenetic barrier in porcine nuclear reprogramming. Reproduction. 2016;151:9-16 pubmed publisher
    ..Then GSK126 and GSK-J4, two small molecule inhibitors of H3K27me3 methylase (EZH2) and demethylases (UTX/JMJD3), were used to regulate the H3K27me3 level...
  37. Pappas K, Xu J, Zairis S, Resnick Silverman L, Abate F, Steinbach N, et al. p53 Maintains Baseline Expression of Multiple Tumor Suppressor Genes. Mol Cancer Res. 2017;15:1051-1062 pubmed publisher
    ..but not mutant p53 binds and activates numerous tumor suppressor genes, including PTEN, STK11(LKB1), miR-34a, KDM6A(UTX), FOXO1, PHLDA3, and TNFRSF10B through consensus binding sites in enhancers and promoters...
  38. Rocha Viegas L, Villa R, Gutierrez A, Iriondo O, Shiekhattar R, Di Croce L. Role of UTX in retinoic acid receptor-mediated gene regulation in leukemia. Mol Cell Biol. 2014;34:3765-75 pubmed publisher
    Human UTX, a member of the Jumonji C family of proteins, associates with mixed-lineage leukemia 3/4 complexes...
  39. Brucker S, Brannstrom M, Taran F, Nadalin S, Konigsrainer A, Rall K, et al. Selecting living donors for uterus transplantation: lessons learned from two transplantations resulting in menstrual functionality and another attempt, aborted after organ retrieval. Arch Gynecol Obstet. 2018;297:675-684 pubmed publisher
    ..donor selection criteria based on our experience with two successful living-donor human uterus transplantations (UTx) and an aborted attempt...
  40. Rai K, Akdemir K, Kwong L, Fiziev P, Wu C, Keung E, et al. Dual Roles of RNF2 in Melanoma Progression. Cancer Discov. 2015;5:1314-27 pubmed publisher
    ..We further show that MEK1-mediated phosphorylation of RNF2 promotes recruitment of activating histone modifiers UTX and p300 to a subset of poised promoters, which activates gene expression...
  41. Saso S, Clarke A, Bracewell Milnes T, Saso A, Al Memar M, Thum M, et al. Psychological Issues Associated With Absolute Uterine Factor Infertility and Attitudes of Patients Toward Uterine Transplantation. Prog Transplant. 2016;26:28-39 pubmed publisher
    Uterine transplantation (UTx). To explore patients' knowledge of and attitudes toward UTx before and after a short educational intervention via a video and question and answer (Q&A) session...
  42. Hariton E, Bortoletto P, Goldman R, Farland L, Ginsburg E, Gargiulo A. A Survey of Public Opinion in the United States Regarding Uterine Transplantation. J Minim Invasive Gynecol. 2018;25:980-985 pubmed publisher
    To evaluate the opinions and attitudes of the general public regarding uterine transplantation (UTx) in the United States. A cross-sectional study (Canadian Task Force classification II-2). A Web-based survey...
  43. Lei X, Jiao J. UTX Affects Neural Stem Cell Proliferation and Differentiation through PTEN Signaling. Stem Cell Reports. 2018;10:1193-1207 pubmed publisher
    ..Although epigenetic modification has been reportedly involved in the regulation of the cerebral cortex, whether UTX, an H3K27me3 demethylase, regulates the development of cerebral cortex during the embryonic period is unclear...
  44. Watanabe S, Murakami A. Regulation of Retinal Development via the Epigenetic Modification of Histone H3. Adv Exp Med Biol. 2016;854:635-41 pubmed publisher
    ..Ezh1 and Ezh2 are methyltransferases that act on H3K27, while Jmjd3 and Utx are demethylases...
  45. Dunford A, Weinstock D, Savova V, Schumacher S, Cleary J, Yoda A, et al. Tumor-suppressor genes that escape from X-inactivation contribute to cancer sex bias. Nat Genet. 2017;49:10-16 pubmed publisher
    ..Six of 783 non-pseudoautosomal region (PAR) X-chromosome genes (ATRX, CNKSR2, DDX3X, KDM5C, KDM6A, and MAGEC3) harbored loss-of-function mutations more frequently in males (based on a false discovery rate < 0...
  46. Copur Ö, Muller J. Histone Demethylase Activity of Utx Is Essential for Viability and Regulation of HOX Gene Expression in Drosophila. Genetics. 2018;208:633-637 pubmed publisher
    ..However, the role of enzymatic demethylation of H3K27me3 by the KDM6-family demethylases Utx, Uty, and JmjD3 is less clear...
  47. Järvholm S, Johannesson L, Clarke A, Brännström M. Uterus transplantation trial: Psychological evaluation of recipients and partners during the post-transplantation year. Fertil Steril. 2015;104:1010-1015 pubmed publisher
    To explore the psychology and well-being of the nine patients undergoing uterus transplantation (UTx) as part of the first clinical trial, during the first 12 months of which seven patients experienced graft survival with occasional mild ..
  48. Zhou Y, Zheng L, Li F, Wan M, Fan Y, Du W, et al. Bivalent Histone Codes on WNT5A during Odontogenic Differentiation. J Dent Res. 2018;97:99-107 pubmed publisher
    ..Associated H3K4me3 methylases (mixed-lineage leukemia [MLL] complex) and H3K27me3 demethylases (JMJD3 and UTX) were dynamically expressed between early and late bell stage of human tooth germs and in cultured human dental ..
  49. Zha L, Cao Q, Cui X, Li F, Liang H, Xue B, et al. Epigenetic regulation of E-cadherin expression by the histone demethylase UTX in colon cancer cells. Med Oncol. 2016;33:21 pubmed publisher
    ..Here, we identified ubiquitously transcribed tetratricopeptide repeat on chromosome X (UTX), a histone demethylase involved in demethylating di- or tri-methylated histone 3 lysine 27 (H3K27me2/3), as a ..
  50. Petrov N, Vereschagina N, Sushilova E, Kropotov A, Miheeva N, Popov B. [PRODUCT OF THE BMI1--A KEY COMPONENT OF POLYCOMB--POSITIVELY REGULATES ADIPOCYTE DIFFERENTIATION OF MOUSE MESENCHYMAL STEM CELLS]. Tsitologiia. 2016;58:83-90 pubmed
    ..associated with an increase in the expression levels of BMI1, the genes of pRb family (RB, p130) and demethylase UTX, but not methyltransferase EZH2, whose products regulate the methylation levels of H3K27...
  51. Froimchuk E, Jang Y, Ge K. Histone H3 lysine 4 methyltransferase KMT2D. Gene. 2017;627:337-342 pubmed publisher
    ..KMT2D associates with WRAD (WDR5, RbBP5, ASH2L, and DPY30), NCOA6, PTIP, PA1, and H3K27 demethylase UTX in one protein complex...
  52. Wiedemuth R, Thieme S, Navratiel K, Dorschner B, Brenner S. UTX - moonlighting in the cytoplasm?. Int J Biochem Cell Biol. 2018;97:78-82 pubmed publisher
    The X-linked histone demethylase UTX has a pivotal role in cellular and developmental processes including embryogenesis, hematopoiesis and cancer...
  53. Jankowska A, Makishima H, Tiu R, Szpurka H, Huang Y, Traina F, et al. Mutational spectrum analysis of chronic myelomonocytic leukemia includes genes associated with epigenetic regulation: UTX, EZH2, and DNMT3A. Blood. 2011;118:3932-41 pubmed publisher
    ..At least 1 mutation was found in 86% of all cases; novel UTX, DNMT3A, and EZH2 mutations were found in 8%, 10%, and 5.5% of patients, respectively...
  54. Van Laarhoven P, Neitzel L, Quintana A, Geiger E, Zackai E, Clouthier D, et al. Kabuki syndrome genes KMT2D and KDM6A: functional analyses demonstrate critical roles in craniofacial, heart and brain development. Hum Mol Genet. 2015;24:4443-53 pubmed publisher
    ..While mutations in KMT2D have been identified in a majority of KS patients, a few patients have mutations in KDM6A. We analyzed 40 individuals clinically diagnosed with KS for mutations in KMT2D and KDM6A...
  55. Wang J, Liu L, Xi W, Long Q, Wang Y, Bai Q, et al. Prognostic value of UTX expression in patients with clear cell renal cell carcinoma. Urol Oncol. 2016;34:338.e19-27 pubmed publisher
    ..Ubiquitously transcribed tetratricopeptide repeat on chromosome X (UTX) has been demonstrated as a histone demethylase that specifically targets di-methyl groups and tri-methyl groups on ..
  56. Chakroun I, Yang D, Girgis J, Gunasekharan A, Phenix H, Kærn M, et al. Genome-wide association between Six4, MyoD, and the histone demethylase Utx during myogenesis. FASEB J. 2015;29:4738-55 pubmed publisher
    ..adult myoblasts, the cooperation between Six4 and MyoD is associated with chromatin repressive mark removal by Utx, a demethylase of histone H3 trimethylated at lysine 27...
  57. Huet S, Tardieu A, Filloux M, Essig M, Pichon N, Therme J, et al. Uterus transplantation in France: for which patients?. Eur J Obstet Gynecol Reprod Biol. 2016;205:7-10 pubmed publisher
    ..Uterus transplantation (UTx), at the current stage of research, offers hope for these women to be both the biological mother and the carrier of ..
  58. Dentici M, Di Pede A, Lepri F, Gnazzo M, Lombardi M, Auriti C, et al. Kabuki syndrome: clinical and molecular diagnosis in the first year of life. Arch Dis Child. 2015;100:158-64 pubmed publisher
    ..Molecular analysis of the known causative genes of KS, KMT2D/MLL2 and KDM6A, was performed through MiSeq-targeted sequencing platform...
  59. Cook K, Shpargel K, Starmer J, Whitfield Larry F, Conley B, Allard D, et al. T Follicular Helper Cell-Dependent Clearance of a Persistent Virus Infection Requires T Cell Expression of the Histone Demethylase UTX. Immunity. 2015;43:703-14 pubmed publisher
    ..We show that UTX, a histone H3 lysine 27 (H3K27) demethylase, supports T follicular helper (Tfh) cell responses that are essential ..
  60. Foresta C, Ferlin A, Moro E. Deletion and expression analysis of AZFa genes on the human Y chromosome revealed a major role for DBY in male infertility. Hum Mol Genet. 2000;9:1161-9 pubmed
    ..This hypothesis is further supported by the high similarity of DBY to other DEAD box proteins belonging to the PL10 subclass. ..
  61. Patel S, Kim D, Levitan I, Dressler G. The BRCT-domain containing protein PTIP links PAX2 to a histone H3, lysine 4 methyltransferase complex. Dev Cell. 2007;13:580-92 pubmed
    ..Embryonic lethal ptip-null mutants and conditional mutants both show reduced levels of methylated H3K4. Thus, PTIP bridges DNA-binding developmental regulators to histone methyltransferase-dependent epigenetic regulation. ..
  62. Tarpey P, Smith R, Pleasance E, Whibley A, Edkins S, Hardy C, et al. A systematic, large-scale resequencing screen of X-chromosome coding exons in mental retardation. Nat Genet. 2009;41:535-43 pubmed publisher
    ..The study has, however, also highlighted issues confronting whole-genome sequencing screens, including the observation that loss of function of 1% or more of X-chromosome genes is compatible with apparently normal existence. ..
  63. Lederer D, Grisart B, Digilio M, Benoit V, Crespin M, Ghariani S, et al. Deletion of KDM6A, a histone demethylase interacting with MLL2, in three patients with Kabuki syndrome. Am J Hum Genet. 2012;90:119-24 pubmed publisher
    ..Here, we describe three KS individuals with de novo partial or complete deletions of an X chromosome gene, KDM6A, that encodes a histone demethylase that interacts with MLL2...
  64. Dubuc A, Remke M, Korshunov A, Northcott P, Zhan S, Mendez Lago M, et al. Aberrant patterns of H3K4 and H3K27 histone lysine methylation occur across subgroups in medulloblastoma. Acta Neuropathol. 2013;125:373-84 pubmed publisher
    ..Notably, we also report mutations affecting the MLL2-binding partner KDM6A, in 4 % (7/175) of tumors...
  65. Kim J, Sharma A, Dhar S, Lee S, Gu B, Chan C, et al. UTX and MLL4 coordinately regulate transcriptional programs for cell proliferation and invasiveness in breast cancer cells. Cancer Res. 2014;74:1705-17 pubmed publisher
    ..Here, we show that in breast cancer cells, the histone H3 lysine 27 (H3K27) demethylase UTX (also known as KDM6A) positively regulates gene expression programs associated with cell proliferation and invasion...
  66. Cheon C, Sohn Y, Ko J, Lee Y, Song J, Moon J, et al. Identification of KMT2D and KDM6A mutations by exome sequencing in Korean patients with Kabuki syndrome. J Hum Genet. 2014;59:321-5 pubmed publisher
    ..Recently, pathogenic variants in KMT2D and KDM6A were identified as the causes of KS in 55.8-80.0% of patients...
  67. Cregan S, Breslin M, Roche G, Wennstedt S, MacDonagh L, Albadri C, et al. Kdm6a and Kdm6b: Altered expression in malignant pleural mesothelioma. Int J Oncol. 2017;50:1044-1052 pubmed publisher
    ..Inflammation is thought to be a key element in the pathogenesis of MPM, and recently Kdm6 family members (Kdm6a and Kdm6b) have been identified as playing important roles in inflammatory processes...
  68. Wang S, Tang Z, Chen C, Shimada M, Koche R, Wang L, et al. A UTX-MLL4-p300 Transcriptional Regulatory Network Coordinately Shapes Active Enhancer Landscapes for Eliciting Transcription. Mol Cell. 2017;67:308-321.e6 pubmed publisher
    ..Here we report an epigenetic crosstalk at enhancers between the UTX (H3K27 demethylase)-MLL4 (H3K4 methyltransferase) complex and the histone acetyltransferase p300...
  69. Shpargel K, Starmer J, Wang C, Ge K, Magnuson T. UTX-guided neural crest function underlies craniofacial features of Kabuki syndrome. Proc Natl Acad Sci U S A. 2017;114:E9046-E9055 pubmed publisher
    ..a congenital craniofacial disorder, manifests from mutations in an X-linked histone H3 lysine 27 demethylase (UTX/KDM6A) or a H3 lysine 4 methylase (KMT2D)...
  70. De Santa F, Totaro M, Prosperini E, Notarbartolo S, Testa G, Natoli G. The histone H3 lysine-27 demethylase Jmjd3 links inflammation to inhibition of polycomb-mediated gene silencing. Cell. 2007;130:1083-94 pubmed
  71. Newby P, Pickles O, Mazumdar S, Brand O, Carr Smith J, Pearce S, et al. Follow-up of potential novel Graves' disease susceptibility loci, identified in the UK WTCCC genome-wide nonsynonymous SNP study. Eur J Hum Genet. 2010;18:1021-6 pubmed publisher
    ..remained in the combined collection of 5924 subjects for four of the nsSNPs, present within HDLBP, TEKT1, JSRP1 and UTX. An additional 29 Tag SNPs were screened within these four gene regions to determine if further associations could ..
  72. Priolo M, Micale L, Augello B, Fusco C, Zucchetti F, Prontera P, et al. Absence of deletion and duplication of MLL2 and KDM6A genes in a large cohort of patients with Kabuki syndrome. Mol Genet Metab. 2012;107:627-9 pubmed publisher
    ..syndrome is a rare, multiple congenital anomaly/mental retardation syndrome caused by MLL2 point mutations and KDM6A microdeletions...
  73. Akdemir K, Jain A, Allton K, Aronow B, Xu X, Cooney A, et al. Genome-wide profiling reveals stimulus-specific functions of p53 during differentiation and DNA damage of human embryonic stem cells. Nucleic Acids Res. 2014;42:205-23 pubmed publisher
    ..Activation of these genes occurs with recruitment of p53 and H3K27me3-specific demethylases, UTX and JMJD3, to chromatin...
  74. Nickerson M, Dancik G, Im K, Edwards M, Turan S, Brown J, et al. Concurrent alterations in TERT, KDM6A, and the BRCA pathway in bladder cancer. Clin Cancer Res. 2014;20:4935-48 pubmed publisher
    ..of the TERT promoter, and to examine the functional relevance of histone lysine (K)-specific demethylase 6A (KDM6A/UTX), a frequently mutated histone demethylase, in bladder cancer. We analyzed bladder cancer samples from 54 U.S...
  75. Tang G, Zeng Y, Liu P, Mi T, Zhang S, Dai S, et al. The Histone H3K27 Demethylase UTX Regulates Synaptic Plasticity and Cognitive Behaviors in Mice. Front Mol Neurosci. 2017;10:267 pubmed publisher
    b>Histone demethylase UTX mediates removal of repressive trimethylation of histone H3 lysine 27 (H3K27me3) to establish a mechanistic switch to activate large sets of genes...
  76. Rejlová K, Musilova A, Skvarova Kramarzova K, Zaliova M, Fiser K, Alberich Jorda M, et al. LOW HOX gene expression in PML-RAR?-POSITIVE leukemia results from suppressed histone demethylation. Epigenetics. 2017;:1-25 pubmed publisher
    ..found an association between the mRNA levels of HOX genes and those of the histone demethylases JMJD3 and UTX in PML-RAR?- positive leukemia patients...
  77. Majumder S, Thieme K, Batchu S, Alghamdi T, Bowskill B, Kabir M, et al. Shifts in podocyte histone H3K27me3 regulate mouse and human glomerular disease. J Clin Invest. 2018;128:483-499 pubmed publisher
    ..Conversely, inhibition of the Jumonji C domain-containing demethylases Jmjd3 and UTX increased the H3K27me3 content of podocytes and attenuated glomerular disease in adriamycin nephrotoxicity, SNx, ..
  78. Hübner M, Spector D. Role of H3K27 demethylases Jmjd3 and UTX in transcriptional regulation. Cold Spring Harb Symp Quant Biol. 2010;75:43-9 pubmed publisher
    ..The histone H3 lysine 27 (H3K27) demethylases Jmjd3 and UTX remove the gene-inactivating H3K27 dimethyl and trimethyl marks and are involved in inducing and/or maintaining ..
  79. Chen M, Zou Y, Li J, Li Y, Li H, Zhou T. [Identification of ubiquitously expressed transcript as the potential interactor of hepatitis B virus polymerase]. Nan Fang Yi Ke Da Xue Xue Bao. 2011;31:686-9 pubmed
    ..GST-pull down assay confirmed the in vitro interaction between HBV Pol and UXT. UXT is a potential interactor of HBV Pol, and this protein interaction may provide clues of the function of HBV Pol in HBV life cycle. ..
  80. Jiang W, Wang J, Zhang Y. Histone H3K27me3 demethylases KDM6A and KDM6B modulate definitive endoderm differentiation from human ESCs by regulating WNT signaling pathway. Cell Res. 2013;23:122-30 pubmed publisher
    ..Here, we show that the H3K27me3 demethylases KDM6A and KDM6B play an important role in endoderm differentiation from human ESCs...
  81. Thieme S, Gyárfás T, Richter C, Ozhan G, Fu J, Alexopoulou D, et al. The histone demethylase UTX regulates stem cell migration and hematopoiesis. Blood. 2013;121:2462-73 pubmed publisher
    ..cell-derived factor-1 (SDF-1) migration screening assay, we identified the histone 3 lysine 27 demethylase UTX (Kdm6a) as a novel regulator for hematopoietic cell migration...
  82. McVeigh T, Banka S, Reardon W. Kabuki syndrome: expanding the phenotype to include microphthalmia and anophthalmia. Clin Dysmorphol. 2015;24:135-9 pubmed publisher
    ..Kabuki syndrome may be caused by mutations in one of two histone methyltransferase genes: KMT2D and KDM6A. We describe a male child of nonconsanguineous Irish parents presenting with multiple malformations, including ..
  83. Choi H, Park J, Park M, Won H, Joo H, Lee C, et al. UTX inhibits EMT-induced breast CSC properties by epigenetic repression of EMT genes in cooperation with LSD1 and HDAC1. EMBO Rep. 2015;16:1288-98 pubmed publisher
    The histone H3K27 demethylase, UTX, is a known component of the H3K4 methyltransferase MLL complex, but its functional association with H3K4 methylation in human cancers remains largely unknown...
  84. Paderova J, Holubova A, Simandlova M, Puchmajerova A, Vlckova M, Malikova M, et al. Molecular genetic analysis in 14 Czech Kabuki syndrome patients is confirming the utility of phenotypic scoring. Clin Genet. 2016;90:230-7 pubmed publisher
    Kabuki syndrome (KS) is a dominantly inherited disorder mainly due to de novo pathogenic variation in KMT2D or KDM6A genes...
  85. Ahn J, Kim K, Park S, Ahn Y, Kim H, Yoon H, et al. Target sequencing and CRISPR/Cas editing reveal simultaneous loss of UTX and UTY in urothelial bladder cancer. Oncotarget. 2016;7:63252-63260 pubmed publisher
    b>UTX is a histone demethylase gene located on the X chromosome and is a frequently mutated gene in urothelial bladder cancer (UBC). UTY is a paralog of UTX located on the Y chromosome...
  86. Hong Z, Li H, Li L, Wang W, Xu T. Different expression patterns of histone H3K27 demethylases in renal cell carcinoma and bladder cancer. Cancer Biomark. 2017;18:125-131 pubmed publisher
    b>UTX and JMJD3 are recently identified histone H3 lysine 27 (H3K27) demethylases...
  87. Morozov V, Li Y, Clowers M, Ishov A. Inhibitor of H3K27 demethylase JMJD3/UTX GSK-J4 is a potential therapeutic option for castration resistant prostate cancer. Oncotarget. 2017;8:62131-62142 pubmed publisher
    ..epigenetic modification H3K27me2/3 correlates with PCa aggressiveness, while corresponding demethylases JMJD3/UTX are overexpressed in PCa...
  88. Kanemitsu Y, Asaji K, Matsumoto Y, Tsukamoto H, Saigusa D, Mukawa C, et al. Simultaneous quantitative analysis of uremic toxins by LC-MS/MS with a reversed-phase/cation-exchange/anion-exchange tri-modal mixed-mode column. J Chromatogr B Analyt Technol Biomed Life Sci. 2017;1068-1069:1-8 pubmed publisher
    ..tri-modal column (Scherzo SS-C18; Imtakt) for the simultaneous quantification of various uremic toxins (UTx), including creatinine, 1-methyladenosine, trimethylamine-N-oxide, indoxyl sulfate, p-cresyl sulfate, phenyl ..
  89. Hyland P, McDade S, McCloskey R, Dickson G, Arthur K, McCance D, et al. Evidence for alteration of EZH2, BMI1, and KDM6A and epigenetic reprogramming in human papillomavirus type 16 E6/E7-expressing keratinocytes. J Virol. 2011;85:10999-1006 pubmed publisher
    ..In contrast, these cells show a reduction in global H3K27me3 levels in vitro, as well as upregulation of the KDM6A demethylase...
  90. Rossetto C, Pari G. KSHV PAN RNA associates with demethylases UTX and JMJD3 to activate lytic replication through a physical interaction with the virus genome. PLoS Pathog. 2012;8:e1002680 pubmed publisher
    ..RNA chromatin immunoprecipitation assays show that PAN RNA interacts with demethylases JMJD3 and UTX, and the histone methyltransferase MLL2...
  91. Paolicchi E, Crea F, Farrar W, Green J, Danesi R. Histone lysine demethylases in breast cancer. Crit Rev Oncol Hematol. 2013;86:97-103 pubmed publisher
    ..005 and response to docetaxel p=0.005); conversely, KDM6A is overexpressed in BC patients with an unfavorable prognosis (mortality at 1 year, p=8.65E-7)...