KCNN3

Summary

Gene Symbol: KCNN3
Description: potassium calcium-activated channel subfamily N member 3
Alias: KCa2.3, SK3, SKCA3, hSK3, small conductance calcium-activated potassium channel protein 3, SKCa 3, potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 3, potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3, small conductance calcium-activated potassium channel 3
Species: human
Products:     KCNN3

Top Publications

  1. Chandy K, Fantino E, Wittekindt O, Kalman K, Tong L, Ho T, et al. Isolation of a novel potassium channel gene hSKCa3 containing a polymorphic CAG repeat: a candidate for schizophrenia and bipolar disorder?. Mol Psychiatry. 1998;3:32-7 pubmed
    ..These polyglutamine repeats may modulate hSKCa3 channel function and neuronal excitability, and thereby increase disease risk when combined with other genetic and environmental effects. ..
  2. Dror V, Shamir E, Ghanshani S, Kimhi R, Swartz M, Barak Y, et al. hKCa3/KCNN3 potassium channel gene: association of longer CAG repeats with schizophrenia in Israeli Ashkenazi Jews, expression in human tissues and localization to chromosome 1q21. Mol Psychiatry. 1999;4:254-60 pubmed
    We demonstrate a significant association between longer CAG repeats in the hKCa3/KCNN3 calcium-activated potassium channel gene and schizophrenia in Israeli Ashkenazi Jews...
  3. Rimini R, Rimland J, Terstappen G. Quantitative expression analysis of the small conductance calcium-activated potassium channels, SK1, SK2 and SK3, in human brain. Brain Res Mol Brain Res. 2000;85:218-20 pubmed
    ..In the present study, we report the first quantitative analysis of SK1, SK2 and SK3 expression in human brain using TaqMan RT-PCR on a range of human brain and peripheral tissue samples...
  4. Miller M, Tomita H, Rauer H, Gargus J, Gutman G, Cahalan M, et al. Nuclear localization and dominant-negative suppression by a mutant SKCa3 N-terminal channel fragment identified in a patient with schizophrenia. J Biol Chem. 2001;276:27753-6 pubmed
    The small conductance calcium-activated K+ channel gene SKCa3/KCNN3 maps to 1q21, a region strongly linked to schizophrenia...
  5. Ritsner M, Modai I, Ziv H, Amir S, Halperin T, Weizman A, et al. An association of CAG repeats at the KCNN3 locus with symptom dimensions of schizophrenia. Biol Psychiatry. 2002;51:788-94 pubmed
    In 1999 Cardno et al reported that long CAG repeats in the calcium-activated potassium channel gene hSKCa3/KCNN3 are associated with higher negative symptom dimension scores in schizophrenia patients...
  6. Curtain R, Sundholm J, Lea R, Ovcaric M, MacMillan J, Griffiths L. Association analysis of a highly polymorphic CAG Repeat in the human potassium channel gene KCNN3 and migraine susceptibility. BMC Med Genet. 2005;6:32 pubmed
    ..Mutations in various ion channel genes are responsible for a number of neurological disorders. KCNN3 is a neuronal small conductance calcium-activated potassium channel gene that contains two polyglutamine tracts, ..
  7. Kohler M, Hirschberg B, Bond C, Kinzie J, Marrion N, Maylie J, et al. Small-conductance, calcium-activated potassium channels from mammalian brain. Science. 1996;273:1709-14 pubmed
  8. Wittekindt O, Jauch A, Burgert E, Scharer L, Holtgreve Grez H, Yvert G, et al. The human small conductance calcium-regulated potassium channel gene (hSKCa3) contains two CAG repeats in exon 1, is on chromosome 1q21.3, and shows a possible association with schizophrenia. Neurogenetics. 1998;1:259-65 pubmed
    ..Both CAG repeats have been typed in 86 bipolar I disorder patients, and no significant difference in allele distribution was observed between our bipolar disorder patients and controls. ..
  9. Koronyo Hamaoui M, Danziger Y, Frisch A, Stein D, Leor S, Laufer N, et al. Association between anorexia nervosa and the hsKCa3 gene: a family-based and case control study. Mol Psychiatry. 2002;7:82-5 pubmed
    ..005). Our study suggests that the longer repeat alleles of the hSKCa3 gene may contribute to the genetic susceptibility to AN. ..

More Information

Publications150 found, 100 shown here

  1. Glatt S, Faraone S, Tsuang M. CAG-repeat length in exon 1 of KCNN3 does not influence risk for schizophrenia or bipolar disorder: a meta-analysis of association studies. Am J Med Genet B Neuropsychiatr Genet. 2003;121B:14-20 pubmed
    ..The gene KCNN3, which codes for a small/intermediate conductance, calcium-regulated potassium channel, contains a highly ..
  2. Monaghan A, Benton D, Bahia P, Hosseini R, Shah Y, Haylett D, et al. The SK3 subunit of small conductance Ca2+-activated K+ channels interacts with both SK1 and SK2 subunits in a heterologous expression system. J Biol Chem. 2004;279:1003-9 pubmed
    The aim of this study was to determine whether functional heteromeric channels can be formed by co-assembly of rat SK3 (rSK3) potassium channel subunits with either SK1 or SK2 subunits...
  3. Wei A, Gutman G, Aldrich R, Chandy K, Grissmer S, Wulff H. International Union of Pharmacology. LII. Nomenclature and molecular relationships of calcium-activated potassium channels. Pharmacol Rev. 2005;57:463-72 pubmed
  4. Lu C, Huang X, Lu H, Liu S, Zang J, Li Y, et al. Different distributions of interstitial cells of Cajal and platelet-derived growth factor receptor-α positive cells in colonic smooth muscle cell/interstitial cell of Cajal/platelet-derived growth factor receptor-α positive cell syncytium in mice. World J Gastroenterol. 2018;24:4989-5004 pubmed publisher
    ..higher, while protein expression levels of PDGFRα and small conductance calcium-activated potassium channel 3 (SK3) in the distal colon were much higher...
  5. Hongyuan B, Xin D, Jingwen Z, Li G, Yajuan N. Apamin-Sensitive Small Conductance Calcium-Activated Potassium Channels were Negatively Regulated by Captopril in Volume-Overload Heart Failure Rats. J Membr Biol. 2016;249:429-36 pubmed publisher
    ..The results of real-time PCR and Western blot demonstrated captopril decreased the mRNA and protein expression of SK3 channels...
  6. Hsueh C, Chang P, Hsieh Y, Reher T, Chen P, Lin S. Proarrhythmic effect of blocking the small conductance calcium activated potassium channel in isolated canine left atrium. Heart Rhythm. 2013;10:891-8 pubmed publisher
    ..This study provides supportive evidence of genome-wide association studies showing association of KCNN3 and lone atrial fibrillation.
  7. Steinestel K. [Regulator proteins of actin dynamics as possible targets of antineoplastic therapies]. Pathologe. 2018;39:225-230 pubmed publisher
    ..Edelfosin, an alkyl-lipid blocker of the Abi1 interaction partner SK3, inhibits invasion of urothelial carcinoma cells...
  8. Daruich A, Matet A, Dirani A, Bousquet E, Zhao M, Farman N, et al. Central serous chorioretinopathy: Recent findings and new physiopathology hypothesis. Prog Retin Eye Res. 2015;48:82-118 pubmed publisher
  9. Larson R, Gui L, Huber M, Chapp A, Zhu J, LaGrange L, et al. Sympathoexcitation in ANG II-salt hypertension involves reduced SK channel function in the hypothalamic paraventricular nucleus. Am J Physiol Heart Circ Physiol. 2015;308:H1547-55 pubmed publisher
    ..Finally, Western blot analysis showed no statistical difference in SK1-SK3 expression in the PVN between NS and ANG II-salt HTN...
  10. Welling P. Roles and Regulation of Renal K Channels. Annu Rev Physiol. 2016;78:415-35 pubmed publisher
    ..five different potassium channels in the distal nephron, encoded by the genes KCNJ1, KCNJ10, KCNJ16, KCNMA1, and KCNN3. Research aimed at understanding how these channels work in health and go awry in disease has transformed our ..
  11. Cantonero C, Sánchez Collado J, González Núñez M, Salido G, Lopez J, Jardin I, et al. Store-independent Orai1-mediated Ca2+ entry and cancer. Cell Calcium. 2019;80:1-7 pubmed publisher
    ..physical and functional interaction with the small conductance Ca2+-activated K+ channel 3 (SK3) or the voltage-dependent Kv10.1 channel...
  12. Shamsaldeen Y, Culliford L, Clout M, James A, Ascione R, Hancox J, et al. Role of SK channel activation in determining the action potential configuration in freshly isolated human atrial myocytes from the SKArF study. Biochem Biophys Res Commun. 2019;512:684-690 pubmed publisher
    ..Immuno-visualization of the subcellular localization of SK2 and SK3 subunits showed a high degree of colocalization, consistent with the formation of heteromeric SK2/SK3 channels...
  13. Potier M, Chantome A, Joulin V, Girault A, Roger S, Besson P, et al. The SK3/K(Ca)2.3 potassium channel is a new cellular target for edelfosine. Br J Pharmacol. 2011;162:464-79 pubmed publisher
    ..migration of breast cancer MDA-MB-435s cells, mediated by the small conductance Ca²(+) -activated K(+) channel, SK3/K(Ca)2.3...
  14. Lozano Velasco E, Hernández Torres F, Daimi H, Serra S, Herraiz A, Hove Madsen L, et al. Pitx2 impairs calcium handling in a dose-dependent manner by modulating Wnt signalling. Cardiovasc Res. 2016;109:55-66 pubmed publisher
    ..in NppaCrePitx2(+/-) and NppaCrePitx2(-/-) adult mice demonstrate that AF GWAS-associated genes such as Zfhx3, Kcnn3, and Wnt8a are severely impaired but not Cav1, Synpo2l, nor Prrx1...
  15. Choi S, Kim J, Li H, Lee S, Seok Y, Kim T, et al. Altered redox state modulates endothelial KCa2.3 and KCa3.1 levels in normal pregnancy and preeclampsia. Antioxid Redox Signal. 2018;: pubmed publisher
  16. Yi F, Ling T, Lu T, Wang X, Li J, Claycomb W, et al. Down-regulation of the small conductance calcium-activated potassium channels in diabetic mouse atria. J Biol Chem. 2015;290:7016-26 pubmed publisher
    ..We found that in streptozotocin-induced diabetic mice, the expression of SK2 and SK3 isoforms was down-regulated by 85 and 92%, respectively, whereas that of SK1 was not changed...
  17. Aidi Knani S, Pezard L, Mpari B, Ben Hamida J, Sabatier J, Mourre C, et al. Correspondences between the binding characteristics of a non-natural peptide, Lei-Dab7, and the distribution of SK subunits in the rat central nervous system. Eur J Pharmacol. 2015;752:106-11 pubmed publisher
    Small-conductance calcium-activated potassium channels (SK1-SK3 channels) are responsible for long-lasting hyperpolarization following action potential and contribute to the neuronal firing and integration signal...
  18. Xiang F, Xie Z, Feng J, Yang W, Cao Z, Li W, et al. Plectasin, first animal toxin-like fungal defensin blocking potassium channels through recognizing channel pore region. Toxins (Basel). 2015;7:34-42 pubmed publisher
    ..Besides Kv1.3 channel, plectasin could less inhibit Kv1.1, Kv1.2, IKCa, SKCa3, hERG and KCNQ channels at the concentration of 1 μΜ...
  19. Imbert G, Saudou F, Yvert G, Devys D, Trottier Y, Garnier J, et al. Cloning of the gene for spinocerebellar ataxia 2 reveals a locus with high sensitivity to expanded CAG/glutamine repeats. Nat Genet. 1996;14:285-91 pubmed
    ..The sequence of three of them revealed pure CAG stretches. The steep inverse correlation between age of onset and CAG number suggests a higher sensitivity to polyglutamine length than in the other polyglutamine expansion diseases...
  20. Grube S, Gerchen M, Adamcio B, Pardo L, Martin S, Malzahn D, et al. A CAG repeat polymorphism of KCNN3 predicts SK3 channel function and cognitive performance in schizophrenia. EMBO Mol Med. 2011;3:309-19 pubmed publisher
    b>KCNN3, encoding the small conductance calcium-activated potassium channel SK3, harbours a polymorphic CAG repeat in the amino-terminal coding region with yet unproven function...
  21. Oliván Viguera A, Valero M, Coleman N, Brown B, Laría C, Murillo M, et al. A novel pan-negative-gating modulator of KCa2/3 channels, fluoro-di-benzoate, RA-2, inhibits endothelium-derived hyperpolarization-type relaxation in coronary artery and produces bradycardia in vivo. Mol Pharmacol. 2015;87:338-48 pubmed publisher
  22. More A, Mishra J, Hankins G, Yallampalli C, Sathishkumar K. Enalapril Normalizes Endothelium-Derived Hyperpolarizing Factor-Mediated Relaxation in Mesenteric Artery of Adult Hypertensive Rats Prenatally Exposed to Testosterone. Biol Reprod. 2015;92:155 pubmed publisher
    ..enzyme inhibitor enalapril restores EDHF function through regulating the activities of small (Kcnn3) and intermediate (Kcnn4) conductance calcium-activated potassium channels in mesenteric arteries...
  23. Kahar U, Sani M, Chan K, Goh K. Immobilization of α-Amylase from Anoxybacillus sp. SK3-4 on ReliZyme and Immobead Supports. Molecules. 2016;21: pubmed publisher
    Amylase from Anoxybacillus sp. SK3-4 (ASKA) is a thermostable enzyme that produces a high level of maltose from starches...
  24. Berrout J, Mamenko M, Zaika O, Chen L, Zhang W, Pochynyuk O, et al. Emerging role of the calcium-activated, small conductance, SK3 K+ channel in distal tubule function: regulation by TRPV4. PLoS ONE. 2014;9:e95149 pubmed publisher
    ..In the present study we demonstrate that the Ca2+-activated, SK3 (KCa2.3) K+ channel, with high Ca2+-binding affinity, is also expressed in the mouse kidney (RT-PCR, immunoblots)...
  25. Martin R, Babaei M, Choy M, Owens W, Chico T, Keenan D, et al. Genetic variants associated with risk of atrial fibrillation regulate expression of PITX2, CAV1, MYOZ1, C9orf3 and FANCC. J Mol Cell Cardiol. 2015;85:207-14 pubmed publisher
    ..The analyses in peripheral blood showed association between AF risk SNPs and decreased expression of KCNN3 (0.85-fold; p=2.1×10(-4)); and increased expression of SYNE2 (1.12-fold; p=7...
  26. Koronyo Hamaoui M, Gak E, Stein D, Frisch A, Danziger Y, Leor S, et al. CAG repeat polymorphism within the KCNN3 gene is a significant contributor to susceptibility to anorexia nervosa: a case-control study of female patients and several ethnic groups in the Israeli Jewish population. Am J Med Genet B Neuropsychiatr Genet. 2004;131B:76-80 pubmed
    The human small-conductance Ca(2+)-activated potassium channel gene KCNN3 has been involved in mechanisms underlying neuronal function and plasticity...
  27. Goh K, Gan H, Chan K, Chan G, Shahar S, Chong C, et al. Analysis of anoxybacillus genomes from the aspects of lifestyle adaptations, prophage diversity, and carbohydrate metabolism. PLoS ONE. 2014;9:e90549 pubmed publisher
    ..In this study, two high-quality draft genomes were generated from Anoxybacillus spp. SK3-4 and DT3-1, isolated from Malaysian hot springs...
  28. Gunadi -, Sunardi M, Budi N, Kalim A, Iskandar K, Dwihantoro A. The impact of down-regulated SK3 expressions on Hirschsprung disease. BMC Med Genet. 2018;19:24 pubmed publisher
    ..The mechanism is presumed to be down-regulated small-conductance calcium-activated potassium channel 3 (SK3) expression in the HSCR ganglionic intestines...
  29. Badarau E, Dilly S, Wouters J, Seutin V, Liégeois J. Chemical modifications of the N-methyl-laudanosine scaffold point to new directions for SK channels exploration. Bioorg Med Chem Lett. 2014;24:5616-5620 pubmed publisher
    An asparagine or a histidine are present in a similar position in the outer pore region of SK2 and SK3 channels, respectively...
  30. Tsai C, Hsieh C, Chang S, Chuang E, Juang J, Lin L, et al. Next-generation sequencing of nine atrial fibrillation candidate genes identified novel de novo mutations in patients with extreme trait of atrial fibrillation. J Med Genet. 2015;52:28-36 pubmed publisher
    ..Genome-wide association studies (GWAS) have identified common variants in nine genomic regions associated with AF (KCNN3, PRRX1, PITX2, WNT8A, CAV1, C9orf3, SYNE2, HCN4 and ZFHX3 genes); however, the genetic variability of these risk ..
  31. Douda D, Khan M, Grasemann H, Palaniyar N. SK3 channel and mitochondrial ROS mediate NADPH oxidase-independent NETosis induced by calcium influx. Proc Natl Acad Sci U S A. 2015;112:2817-22 pubmed publisher
    ..NOX-independent NETosis is fast and mediated by a calcium-activated small conductance potassium (SK) channel member SK3 and mitochondrial ROS...
  32. Husser D, Buttner P, Ueberham L, Dinov B, Sommer P, Arya A, et al. Association of atrial fibrillation susceptibility genes, atrial fibrillation phenotypes and response to catheter ablation: a gene-based analysis of GWAS data. J Transl Med. 2017;15:71 pubmed publisher
    Previous studies have suggested PITX2, KCNN3 and ZFHX3 as atrial fibrillation (AF) susceptibility genes...
  33. Hunziker M, O Donnell A, Puri P. Platelet-derived growth factor receptor alpha-positive cells: a new cell type in the human ureteropelvic junction. Pediatr Res. 2017;82:1080-1087 pubmed publisher
    ..PDGFR?+ cells expressed SK3 channels, which are thought to mediate purinergic inhibitory neurotransmission in SMCs...
  34. Matschke L, Rinné S, Snutch T, Oertel W, Dolga A, Decher N. Calcium-activated SK potassium channels are key modulators of the pacemaker frequency in locus coeruleus neurons. Mol Cell Neurosci. 2018;88:330-341 pubmed publisher
    ..Although we found a transcriptional expression of SK1, SK2 and SK3 channels, SK2 was the predominantly expressed subunit in mouse LC neurons...
  35. Padula A, Griffin W, Lopez M, Nimitvilai S, Cannady R, McGuier N, et al. KCNN Genes that Encode Small-Conductance Ca2+-Activated K+ Channels Influence Alcohol and Drug Addiction. Neuropsychopharmacology. 2015;40:1928-39 pubmed publisher
    ..Alcohol preference and dependence QTLs contain KCNN2 and KCNN3, and Kcnn3 transcript levels in the nucleus accumbens (NAc) of genetically diverse BXD strains of mice predicted ..
  36. Gao Y, Bertuccio C, Balut C, Watkins S, Devor D. Dynamin- and Rab5-dependent endocytosis of a Ca2+ -activated K+ channel, KCa2.3. PLoS ONE. 2012;7:e44150 pubmed publisher
    ..3 is localized to a caveolin-rich domain within the plasma membrane and is endocytosed in a dynamin- and Rab5-dependent manner prior to entering the Rab35/EPI64C recycling compartment and returning to the plasma membrane. ..
  37. Nam Y, Baskoylu S, Gazgalis D, Orfali R, Cui M, Hart A, et al. A V-to-F substitution in SK2 channels causes Ca2+ hypersensitivity and improves locomotion in a C. elegans ALS model. Sci Rep. 2018;8:10749 pubmed publisher
    ..Also, equivalent valine to phenylalanine substitutions in SK1 or SK3 channels conferred Ca2+ hypersensitivity...
  38. Pizzoni A, López González M, Di Giusto G, Rivarola V, Capurro C, Ford P. AQP2 can modulate the pattern of Ca2+ transients induced by store-operated Ca2+ entry under TRPV4 activation. J Cell Biochem. 2018;119:4120-4133 pubmed publisher
    ..We found that AQP2 co-immunoprecipitates with TRPV4 and with the small-conductance potassium channel (SK3)...
  39. Shoemaker M, Bollmann A, Lubitz S, Ueberham L, SAINI H, Montgomery J, et al. Common genetic variants and response to atrial fibrillation ablation. Circ Arrhythm Electrophysiol. 2015;8:296-302 pubmed publisher
    ..single nucleotide polymorphisms (SNPs) at chromosomes 4q25 (rs2200733, rs10033464 near PITX2), 1q21 (rs13376333 in KCNN3), and 16q22 (rs7193343 in ZFHX3) have consistently been associated with the risk of atrial fibrillation (AF)...
  40. Davel A, Lu Q, Moss M, Rao S, Anwar I, Dupont J, et al. Sex-Specific Mechanisms of Resistance Vessel Endothelial Dysfunction Induced by Cardiometabolic Risk Factors. J Am Heart Assoc. 2018;7: pubmed publisher
    ..obese males was overcome by enhanced endothelium-derived hyperpolarization-mediated relaxation along with increased SK3 expression...
  41. Rua C, Gueguinou M, Soubai I, Viel E, Potier Cartereau M, Chantome A, et al. SK3 Gene Polymorphism Is Associated with Taxane Neurotoxicity and Cell Calcium Homeostasis. Clin Cancer Res. 2018;24:5313-5320 pubmed publisher
    ..The calcium-activated potassium channel SK3 is encoded by the KCNN3 gene, which is characterized by a length polymorphism due to variable number of CAG repeats...
  42. Chang S, Chang S, Hwang J, Chiang F, Tseng C, Lee J, et al. Significant association of rs13376333 in KCNN3 on chromosome 1q21 with atrial fibrillation in a Taiwanese population. Circ J. 2012;76:184-8 pubmed
    ..SNP) rs13376333 in potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3 (KCNN3) on chromosome 1q21 with lone atrial fibrillation (AF), indicating a common genetic basis for AF...
  43. Diaz P, Wood A, Sibley C, Greenwood S. Intermediate conductance Ca2+-activated K+ channels modulate human placental trophoblast syncytialization. PLoS ONE. 2014;9:e90961 pubmed publisher
    ..Inappropriate activation of IKCa in pathophysiological conditions could compromise syncytiotrophoblast turnover and volume homeostasis in pregnancy disease. ..
  44. Bragança B, Oliveira Monteiro N, Ferreirinha F, Lima P, Faria M, Fontes Sousa A, et al. Ion Fluxes through KCa2 (SK) and Cav1 (L-type) Channels Contribute to Chronoselectivity of Adenosine A1 Receptor-Mediated Actions in Spontaneously Beating Rat Atria. Front Pharmacol. 2016;7:45 pubmed publisher
    ..1/3.4 channels modulating atrial chronotropy, A1 receptors may additionally restrain KCa2/SK activation thereby compensating atrial inotropic depression by increasing the time available for Ca(2+) influx through Cav1 (L-type) channels. ..
  45. Zhao Y, Xie Z, Feng J, Li W, Cao Z, Wu Y. Pharmacological characterization of human beta-defensins 3 and 4 on potassium channels: Evidence of diversity in beta-defensin-potassium channel interactions. Peptides. 2018;108:14-18 pubmed publisher
    ..Moreover, 1 μM hBD3 inhibited 50.6 ± 3.6% of Kv1.2 channel currents and had smaller effects on Kv1.1, SKCa3, and IKCa channel currents; these effects differed from the Kv1.3 channel-specific inhibitors hBD1 and hBD2...
  46. Ling T, Wang X, Chai Q, Lau T, Koestler C, Park S, et al. Regulation of the SK3 channel by microRNA-499--potential role in atrial fibrillation. Heart Rhythm. 2013;10:1001-9 pubmed publisher
    ..Recently, KCNN3, the gene that encodes the small-conductance calcium-activated potassium channel 3 (SK3), was found to be strongly ..
  47. Fu X, Pan Y, Cao Q, Li B, Wang S, Du H, et al. Metformin restores electrophysiology of small conductance calcium-activated potassium channels in the atrium of GK diabetic rats. BMC Cardiovasc Disord. 2018;18:63 pubmed publisher
    ..2 (SK2 channel) was down-regulated and the expression of KCa2.3 (SK3 channel) was up-regulated in the atrium of GK rats as compared with that of control rats, and metformin reversed ..
  48. Liu H, Yu C, Li H, Ouyang B, Wang T, Zhang J, et al. Overexpression of ShDHN, a dehydrin gene from Solanum habrochaites enhances tolerance to multiple abiotic stresses in tomato. Plant Sci. 2015;231:198-211 pubmed publisher
    Dehydrins (DHNs) play important roles in plant adaptation to abiotic stress. In this study, a cold-induced SK3-type DHN gene (ShDHN) isolated from wild tomato species Solanum habrochaites was characterized for its function in abiotic ..
  49. Halder T, Agarwal T, Ray S. Isolation, cloning, and characterization of a novel Sorghum dehydrin (SbDhn2) protein. Protoplasma. 2016;253:1475-1488 pubmed
    ..We have isolated a novel SK3 type dehydrin from Sorghum capable of protecting the enzyme lactate dehydrogenase in vitro under both cold and high ..
  50. Berthe W, Sevrain C, Chantôme A, Bouchet A, Gueguinou M, Fourbon Y, et al. New Disaccharide-Based Ether Lipids as SK3 Ion Channel Inhibitors. ChemMedChem. 2016;11:1531-9 pubmed publisher
    The SK3 potassium channel is involved in the development of bone metastasis and in the settlement of cancer cells in Ca(2+) -rich environments...
  51. Hancock J, Weatherall K, Choisy S, James A, Hancox J, Marrion N. Selective activation of heteromeric SK channels contributes to action potential repolarization in mouse atrial myocytes. Heart Rhythm. 2015;12:1003-15 pubmed publisher
    ..This pharmacology was matched by that of expressed heteromeric SK2-SK3 channels in HEK293 cells...
  52. Deng Y, Han X, Tang S, Xiao W, Tan Z, Zhou C, et al. Magnolol and honokiol regulate the calcium-activated potassium channels signaling pathway in Enterotoxigenic Escherichia coli-induced diarrhea mice. Eur J Pharmacol. 2015;755:66-73 pubmed publisher
    ..further, upregulated the CaM, BKα1 and BKβ3 mRNA levels but downregulated the IP3 receptors 1, PKC, SK1, SK2, SK3, SK4 and BKβ4 mRNA expressions...
  53. Ro S, Hatton W, Koh S, Horowitz B. Molecular properties of small-conductance Ca2+-activated K+ channels expressed in murine colonic smooth muscle. Am J Physiol Gastrointest Liver Physiol. 2001;281:G964-73 pubmed
    ..The transcripts encoding these subunits (SK1, SK2, and SK3) were detected in murine proximal colon and other peripheral tissues...
  54. Gao Y, Chotoo C, Balut C, Sun F, Bailey M, Devor D. Role of S3 and S4 transmembrane domain charged amino acids in channel biogenesis and gating of KCa2.3 and KCa3.1. J Biol Chem. 2008;283:9049-59 pubmed publisher
    ..Furthermore, these improperly folded K(+) channels are translocated out of the endoplasmic reticulum in a Derlin-1- and p97-dependent fashion, poly-ubiquitylated, and targeted for proteasomal degradation. ..
  55. Steinestel K, Eder S, Ehinger K, Schneider J, Genze F, Winkler E, et al. The small conductance calcium-activated potassium channel 3 (SK3) is a molecular target for Edelfosine to reduce the invasive potential of urothelial carcinoma cells. Tumour Biol. 2016;37:6275-83 pubmed publisher
    ..The small conductance calcium-activated potassium channel 3 (SK3) enhances tumor cell invasion in breast cancer and malignant melanoma...
  56. Babiec W, Jami S, Guglietta R, Chen P, O Dell T. Differential Regulation of NMDA Receptor-Mediated Transmission by SK Channels Underlies Dorsal-Ventral Differences in Dynamics of Schaffer Collateral Synaptic Function. J Neurosci. 2017;37:1950-1964 pubmed publisher
    ..Consistent with this, mRNA levels for the SK3 subunit of SK channels are significantly higher in ventral CA1 pyramidal cells...
  57. He D, Pan Q, Chen Z, Sun C, Zhang P, Mao A, et al. Treatment of hypertension by increasing impaired endothelial TRPV4-KCa2.3 interaction. EMBO Mol Med. 2017;9:1491-1503 pubmed publisher
    ..3. Together, our data highlight the importance of impaired endothelial TRPV4-KCa2.3 coupling in the progression of hypertension and suggest a novel approach for antihypertensive drug development. ..
  58. Ye F, Hu Y, Yu W, Xie Z, Hu J, Cao Z, et al. The Scorpion Toxin Analogue BmKTX-D33H as a Potential Kv1.3 Channel-Selective Immunomodulator for Autoimmune Diseases. Toxins (Basel). 2016;8:115 pubmed publisher
    ..Together, our data indicate that BmKTX-D33H is a Kv1.3 channel-specific blocker. Finally, the remarkable selectivity of BmKTX-D33H highlights the great potential of evolutionary-guided peptide drug design in future studies. ..
  59. Liu Z, Lian B, Dong Q, Sun H, Wei J, Sheng Y, et al. Whole-exome mutational and transcriptional landscapes of combined hepatocellular cholangiocarcinoma and intrahepatic cholangiocarcinoma reveal molecular diversity. Biochim Biophys Acta Mol Basis Dis. 2018;1864:2360-2368 pubmed publisher
    ..ARID1A, PBRM1, and IDH1 were frequently mutated in ICC. RYR3, FBN2, and KCNN3 are associated with cell migration and metastasis and might be driver genes in CHC...
  60. Meira Lima I, Zhao J, Sham P, Pereira A, Krieger J, Vallada H. Association and linkage studies between bipolar affective disorder and the polymorphic CAG/CTG repeat loci ERDA1, SEF2-1B, MAB21L and KCNN3. Mol Psychiatry. 2001;6:565-9 pubmed
    ..locus which is placed in a region where positive linkage results have been reported and the loci MAB21L and KCNN3 as functional candidate genes...
  61. Chen S, Wang C, Wang X, Xu C, Wu M, Wang P, et al. Significant Association Between CAV1 Variant rs3807989 on 7p31 and Atrial Fibrillation in a Chinese Han Population. J Am Heart Assoc. 2015;4: pubmed publisher
    ..We previously replicated the 4q25 locus (PITX2) and 16q22 locus (ZFHX3) in the Chinese population, but not the KCNN3 locus on 1q21...
  62. Yang D, Wang T, Ni Y, Song B, Ning F, Hu P, et al. Apamin-Sensitive K+ Current Upregulation in Volume-Overload Heart Failure is Associated with the Decreased Interaction of CK2 with SK2. J Membr Biol. 2015;248:1181-9 pubmed publisher
    ..In HF rat left ventricle, SK3 was increased by 100 % (P < 0.05), and SK2 was not significantly changed. PP2A protein was increased by 94...
  63. Kushwah N, Jain V, Dheer A, Kumar R, Prasad D, Khan N. Hypobaric Hypoxia-Induced Learning and Memory Impairment: Elucidating the Role of Small Conductance Ca2+-Activated K+ Channels. Neuroscience. 2018;388:418-429 pubmed publisher
    ..study revealed that acute exposure of HH for 3 days leads to significant increase in expression of SK1 and SK3 channels at mRNA and protein levels, which upon chronic exposure restored to normal...
  64. Song K, Zhong X, Xia X, Huang J, Fan Y, Yuan R, et al. Orai1 forms a signal complex with SK3 channel in gallbladder smooth muscle. Biochem Biophys Res Commun. 2015;466:456-62 pubmed publisher
    ..study, we investigated the interaction between Orai1 and small conductance Ca(2+)-activated potassium channel 3 (SK3)...
  65. Song X, Du J, Zhu W, Jin P, Ma F. Identification and characterization of an apoptosis-stimulating protein of p53 (ASPP) gene from Branchiostoma belcheri: Insights into evolution of ASPP gene family. Fish Shellfish Immunol. 2016;49:268-74 pubmed publisher
    ..genome has an ASPP homolog gene with an ORF of 3285 bp, encoding 1094 amino acids which contains ANK repeats and SK3 domain...
  66. Comerma Steffensen S, Kun A, Hedegaard E, Mogensen S, Aalkjaer C, Köhler R, et al. Down-regulation of KCa2.3 channels causes erectile dysfunction in mice. Sci Rep. 2017;7:3839 pubmed publisher
    ..We hypothesized that small-conductance calcium-activated K+ channels (KCa2.3 or SK3) contributes to erectile function...
  67. Khaddaj Mallat R, Mathew John C, Braun A. SKA-31, an activator of endothelial Ca2+-activated K+ channels evokes robust vasodilation in rat mesenteric arteries. Eur J Pharmacol. 2018;831:60-67 pubmed publisher
    ..Collectively, these data highlight the major cellular mechanisms by which the endothelial KCa channel activator SKA-31 inhibits agonist-evoked vasoconstriction in rat small mesenteric arteries. ..
  68. Koot B, Alders M, Verheij J, Beuers U, Cobben J. A de novo mutation in KCNN3 associated with autosomal dominant idiopathic non-cirrhotic portal hypertension. J Hepatol. 2016;64:974-7 pubmed publisher
    ..1348G>C in the KCNN3 gene that was transmitted to all three of his affected offspring...
  69. Yap F, Weber D, Taylor M, Townsley M, Comer B, Maylie J, et al. Endothelial SK3 channel-associated Ca2+ microdomains modulate blood pressure. Am J Physiol Heart Circ Physiol. 2016;310:H1151-63 pubmed publisher
    Activation of vascular endothelial small- (KCa2.3, SK3) or intermediate- (KCa3.1, IK1) conductance Ca(2+)-activated potassium channels induces vasorelaxation via an endothelium-derived hyperpolarization (EDH) pathway...
  70. Li Y, Hu H, Butterworth M, Tian J, Zhu M, O Neil R. Expression of a Diverse Array of Ca2+-Activated K+ Channels (SK1/3, IK1, BK) that Functionally Couple to the Mechanosensitive TRPV4 Channel in the Collecting Duct System of Kidney. PLoS ONE. 2016;11:e0155006 pubmed publisher
    ..subfamilies of KCa channels were revealed: the high Ca2+-binding affinity small-conductance SK channels, SK1and SK3, the intermediate conductance channel, IK1, and the low Ca2+-binding affinity, BK channel (BKα subunit)...
  71. Kumar M, Das A. Molecular identification of multi drug resistant bacteria from urinary tract infected urine samples. Microb Pathog. 2016;98:37-44 pubmed publisher
    ..Four bacterial strains were isolated and identified as Proteus sp. SK3, Pseudomonas sp. ADMK77, Proteus sp. BLKB2 and Enterobacter hormaechei strain CW-3 by 16S rRNA gene sequencing...
  72. Sun G, Tomita H, Shakkottai V, Gargus J. Genomic organization and promoter analysis of human KCNN3 gene. J Hum Genet. 2001;46:463-70 pubmed
    b>KCNN3 is a member of the gene family, KCNN1-4, encoding the small and intermediate conductance calcium-activated potassium channels...
  73. Rhodes J, Monckton D, McAbney J, Prescott A, Duncan G. Increased SK3 expression in DM1 lens cells leads to impaired growth through a greater calcium-induced fragility. Hum Mol Genet. 2006;15:3559-68 pubmed
    ..real-time PCR analysis showed reduced SIX5 expression and increased expression of the Ca(2+)-activated K(+) channel SK3 in the DM1 cells...
  74. Li Y, Hu H, Tian J, Zhu M, O Neil R. Dynamic coupling between TRPV4 and Ca2+-activated SK1/3 and IK1 K+ channels plays a critical role in regulating the K+-secretory BK channel in kidney collecting duct cells. Am J Physiol Renal Physiol. 2017;312:F1081-F1089 pubmed publisher
    ..three small-/intermediate-conductance Ca2+-activated K+ channels, SK1 (KCNN1), SK3 (KCNN3), and IK1 (KCNN4), with notably high Ca2+-binding affinities, that are expressed in CNT/CCD and may be ..
  75. Kahar U, Chan K, Sani M, Mohd Noh N, Goh K. Effects of single and co-immobilization on the product specificity of type I pullulanase from Anoxybacillus sp. SK3-4. Int J Biol Macromol. 2017;104:322-332 pubmed publisher
    Type I pullulanase from Anoxybacillus sp. SK3-4 (PulASK) is an unusual debranching enzyme that specifically hydrolyzes starch α-1,6 linkages at long branches producing oligosaccharides (≥G8), but is nonreactive against short ..
  76. Fujita A, Takeuchi T, Saitoh N, Hanai J, Hata F. Expression of Ca(2+)-activated K(+) channels, SK3, in the interstitial cells of Cajal in the gastrointestinal tract. Am J Physiol Cell Physiol. 2001;281:C1727-33 pubmed
    ..RT-PCR analysis shows expression of SK3 and SK4 mRNA, but not SK1 or SK2 mRNA, in the rat intestine...
  77. Degheidy H, Abbasi F, Mostowski H, Gaigalas A, Marti G, Bauer S, et al. Consistent, multi-instrument single tube quantification of CD20 in antibody bound per cell based on CD4 reference. Cytometry B Clin Cytom. 2016;90:159-67 pubmed publisher
    ..using anti-CD20 antibody (clone L27) in three different fluorochromes relative to anti-CD4 antibody (clone SK3)...
  78. Kohler R, Oliván Viguera A, Wulff H. Endothelial Small- and Intermediate-Conductance K Channels and Endothelium-Dependent Hyperpolarization as Drug Targets in Cardiovascular Disease. Adv Pharmacol. 2016;77:65-104 pubmed publisher
    ..Finally, the authors summarize recent advances in the pharmacology of the channels and explore potential therapeutic utilities of novel channel modulators. ..
  79. Jin D, Hwang H, Oh M, Kim J, Lee M, Kim S, et al. CAG repeats of CTG18.1 and KCNN3 in Korean patients with bipolar affective disorder. J Affect Disord. 2001;66:19-24 pubmed
    ..The purpose of this study was to investigate the association of excess longer allele of KCNN3 and CTG18.1 in the patients with BPAD. CAG/CTG repeat distribution in KCNN3, CTG 18...
  80. Gao Y, Balut C, Bailey M, Patino Lopez G, Shaw S, Devor D. Recycling of the Ca2+-activated K+ channel, KCa2.3, is dependent upon RME-1, Rab35/EPI64C, and an N-terminal domain. J Biol Chem. 2010;285:17938-53 pubmed publisher
    ..3 with Rab35 but significantly decreased the association with RME-1. These represent the first studies elucidating the mechanisms by which KCa2.3 is maintained at the plasma membrane. ..
  81. Sun M, Liu H, Xu H, Wang H, Wang X. CNTF-Treated Astrocyte Conditioned Medium Enhances Large-Conductance Calcium-Activated Potassium Channel Activity in Rat Cortical Neurons. Neurochem Res. 2016;41:1982-92 pubmed publisher
    ..to assess CNTF-ACM's effects upon the protein and mRNA expression, respectively, of the SK channel subunits SK2 and SK3 and the BK channel subunits BK?1 and BK?3...
  82. Ivanova A, Maksimov V, Ivanoshchuk D, Orlov P, Novoselov V, Savchenko S, et al. Association of Polymorphism in SCN5A, GJA5, and KCNN3 Gene with Sudden Cardiac Death. Bull Exp Biol Med. 2017;163:73-77 pubmed publisher
    We studied association of single-nucleotide SCN5A (rs1805124), GJA5 (rs35594137), and KCNN3 (rs13376333) polymorphisms and sudden cardiac death...
  83. Chen J, Zhang C, Yang W, Cao Z, Li W, Chen Z, et al. SjAPI-2 is the first member of a new neurotoxin family with Ascaris-type fold and KCNQ1 inhibitory activity. Int J Biol Macromol. 2015;79:504-10 pubmed publisher
    ..1, Kv1.2, Kv1.3, SKCa2, SKCa3, and IKCa channels...
  84. Marchese M, Valvo G, Moro F, Sicca F, Santorelli F. Targeted Gene Resequencing (Astrochip) to Explore the Tripartite Synapse in Autism-Epilepsy Phenotype with Macrocephaly. Neuromolecular Med. 2016;18:69-80 pubmed publisher
    ..in glutamate transport and metabolism (namely, SLC17A6, GRM8, and GLUL), as well as in potassium conductance (KCNN3)...
  85. Zhou Z, Jiang D, Jia S, Xiao H, Xiao B, Li Y. Down-regulation of endogenous nitric oxide synthase inhibitors on endothelial SK3 expression. Vascul Pharmacol. 2007;47:265-71 pubmed
    ..oxide synthase inhibitor asymmetric dimethylarginine (ADMA) in down-regulation of the expression of endothelial SK3 in atherosclerosis...
  86. Kahar U, Ng C, Chan K, Goh K. Characterization of a type I pullulanase from Anoxybacillus sp. SK3-4 reveals an unusual substrate hydrolysis. Appl Microbiol Biotechnol. 2016;100:6291-307 pubmed publisher
    ..This study reports the analyses of a novel type I pullulanase (PulASK) from Anoxybacillus sp. SK3-4. Purified PulASK (molecular mass of 80 kDa) was stable at pH 5.0-6.0 and was most active at pH 6.0...
  87. Yeoh J, Corrias A, Buist M. A mechanistic model of a PDGFR?(+) cell. J Theor Biol. 2016;408:127-36 pubmed publisher
    ..mediate GI muscle relaxation has been found to be associated with the purine receptors P2Y1 and apamin-sensitive SK3 channels that are highly expressed in these cells...
  88. Mourre C, Manrique C, Camon J, Aidi Knani S, Deltheil T, Turle Lorenzo N, et al. Changes in SK channel expression in the basal ganglia after partial nigrostriatal dopamine lesions in rats: Functional consequences. Neuropharmacology. 2017;113:519-532 pubmed publisher
    ..In situ hybridization of SK2 and SK3 mRNA and binding of iodinated apamin (SK2/SK3 blocker) were performed at 1, 8 or 21 days postsurgery in sham and 6-..
  89. Hong X, Xu C, Yang Q, Wu C. [Transmission disequilibrium analysis of 1137-1140 Del GTGA frameshift mutation within the KCNN3 gene and schizophrenia based on family trios]. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2005;22:441-3 pubmed
    To investigate the relationship between 1137-1140 Del GTGA in exon 1 at KCNN3 gene and schizophrenia. The study included 289 subjects (affected 107; unaffected 182) from 95 schizophrenic trios...
  90. Mizukami K, Yokoshiki H, Mitsuyama H, Watanabe M, Tenma T, Takada S, et al. Small-conductance Ca2+-activated K+ current is upregulated via the phosphorylation of CaMKII in cardiac hypertrophy from spontaneously hypertensive rats. Am J Physiol Heart Circ Physiol. 2015;309:H1066-74 pubmed publisher
    ..66 ± 0.07 vs. 0.40 ± 0.02, both n = 6, P < 0.05), whereas SK1 and SK3 did not differ between groups...
  91. Martin S, Lazzarini M, Dullin C, Balakrishnan S, Gomes F, Ninkovic M, et al. SK3 Channel Overexpression in Mice Causes Hippocampal Shrinkage Associated with Cognitive Impairments. Mol Neurobiol. 2017;54:1078-1091 pubmed publisher
    The dysfunction of the small-conductance calcium-activated K+ channel SK3 has been described as one of the factors responsible for the progress of psychoneurological diseases, but the molecular basis of this is largely unknown...
  92. Liu Q, Williams D, McManus C, Baribaud F, Doms R, Schols D, et al. HIV-1 gp120 and chemokines activate ion channels in primary macrophages through CCR5 and CXCR4 stimulation. Proc Natl Acad Sci U S A. 2000;97:4832-7 pubmed
    ..Intracellular signaling responses of macrophages to HIV-1 may modulate postentry steps of infection and cell functions apart from infection. ..