KCNMA1

Summary

Gene Symbol: KCNMA1
Description: potassium calcium-activated channel subfamily M alpha 1
Alias: BKTM, CADEDS, KCa1.1, MaxiK, PNKD3, SAKCA, SLO, SLO-ALPHA, SLO1, bA205K10.1, hSlo, mSLO1, calcium-activated potassium channel subunit alpha-1, uncharacterized protein, BK channel alpha subunit, BKCA alpha subunit, big potassium channel alpha subunit, calcium-activated potassium channel, subfamily M subunit alpha-1, k(VCA)alpha, maxi-K channel HSLO, potassium channel, calcium activated large conductance subfamily M alpha, member 1, potassium large conductance calcium-activated channel, subfamily M, alpha member 1, slo homolog, slowpoke homolog, stretch-activated Kca channel
Species: human
Products:     KCNMA1

Top Publications

  1. Diaz L, Meera P, Amigo J, Stefani E, Alvarez O, Toro L, et al. Role of the S4 segment in a voltage-dependent calcium-sensitive potassium (hSlo) channel. J Biol Chem. 1998;273:32430-6 pubmed
    We investigated the role of individual charged residues of the S4 region of a MaxiK channel (hSlo) in channel gating...
  2. Niu X, Magleby K. Stepwise contribution of each subunit to the cooperative activation of BK channels by Ca2+. Proc Natl Acad Sci U S A. 2002;99:11441-6 pubmed
    BK channels (Slo1) are widely distributed K+ channels that control Ca2+-dependent processes and cellular excitability. Their activation by intracellular Ca2+ (Ca(i)2+) is highly cooperative, with Hill coefficients of typically 2-5...
  3. Magleby K. Gating mechanism of BK (Slo1) channels: so near, yet so far. J Gen Physiol. 2003;121:81-96 pubmed
  4. Hou S, Xu R, Heinemann S, Hoshi T. The RCK1 high-affinity Ca2+ sensor confers carbon monoxide sensitivity to Slo1 BK channels. Proc Natl Acad Sci U S A. 2008;105:4039-43 pubmed publisher
    ..Among them, large-conductance Ca(2+)- and voltage-gated K(+) (Slo1 BK) channels, important in vasodilation and neuronal firing, have been suggested to be directly stimulated by CO...
  5. Yusifov T, Savalli N, Gandhi C, Ottolia M, Olcese R. The RCK2 domain of the human BKCa channel is a calcium sensor. Proc Natl Acad Sci U S A. 2008;105:376-81 pubmed
    ..We speculate that the molecular rearrangements of RCK2 likely underlie the Ca(2+)-dependent gating mechanism of BK(Ca) channels. A structural model of the heterodimeric complex of hSloRCK1 and hSloRCK2 domains is discussed. ..
  6. Savalli N, Kondratiev A, De Quintana S, Toro L, Olcese R. Modes of operation of the BKCa channel beta2 subunit. J Gen Physiol. 2007;130:117-31 pubmed
    ..Applying voltage clamp fluorometry to fluorescently labeled human BK(Ca) channels (hSlo), we have investigated the mechanisms of operation of the beta(2) subunit...
  7. Hou S, Xu R, Heinemann S, Hoshi T. Reciprocal regulation of the Ca2+ and H+ sensitivity in the SLO1 BK channel conferred by the RCK1 domain. Nat Struct Mol Biol. 2008;15:403-10 pubmed publisher
    ..evidence suggests that intracellular H+ directly stimulates large-conductance Ca2+- and voltage-activated K+ (SLO1 BK) channels, thus providing a crucial link between membrane excitability and cell metabolism...
  8. Sheng J, Weljie A, Sy L, Ling S, Vogel H, Braun A. Homology modeling identifies C-terminal residues that contribute to the Ca2+ sensitivity of a BKCa channel. Biophys J. 2005;89:3079-92 pubmed
    ..These findings, along with other recent data, are considered in the context of the calcium bowl's high affinity Ca(2+) sensor and the known properties of EF hands. ..
  9. Crowley J, Treistman S, Dopico A. Distinct structural features of phospholipids differentially determine ethanol sensitivity and basal function of BK channels. Mol Pharmacol. 2005;68:4-10 pubmed
    ..We addressed these questions by reconstituting BK channels from human brain (hslo) into bilayers that contained phospholipids differing in headgroup size, charge, and acyl chain saturation...

More Information

Publications74

  1. Brainard A, Miller A, Martens J, England S. Maxi-K channels localize to caveolae in human myometrium: a role for an actin-channel-caveolin complex in the regulation of myometrial smooth muscle K+ current. Am J Physiol Cell Physiol. 2005;289:C49-57 pubmed
    ..These data indicate that the actin cytoskeleton is involved as part of a caveolar complex in the regulation of myometrial maxi-K channel function. ..
  2. Chen C, Lamping K, Nuno D, Barresi R, Prouty S, Lavoie J, et al. Abnormal coronary function in mice deficient in alpha1H T-type Ca2+ channels. Science. 2003;302:1416-8 pubmed
    ..Furthermore, acute blockade of T-channels with Ni2+ prevented relaxation of wild-type coronary arteries. Thus, Ca2+ influx through alpha1H T-type Ca2+ channels is essential for normal relaxation of coronary arteries. ..
  3. Liu X, Chang Y, Reinhart P, Sontheimer H, Chang Y. Cloning and characterization of glioma BK, a novel BK channel isoform highly expressed in human glioma cells. J Neurosci. 2002;22:1840-9 pubmed
    ..we report the isolation, cloning, and functional characterization of glioma BK (gBK), a novel splice isoform of hSlo, the gene that encodes the alpha-subunits of human BK channels...
  4. Wang Y, Ding J, Xia X, Lingle C. Consequences of the stoichiometry of Slo1 alpha and auxiliary beta subunits on functional properties of large-conductance Ca2+-activated K+ channels. J Neurosci. 2002;22:1550-61 pubmed
    ..Thus, the stoichiometry of alpha:beta subunit assembly can play a major functional role in defining the apparent Ca2+ dependence of activation of BK channels and in influencing the availability of BK channels for activation. ..
  5. Khaitan D, Sankpal U, Weksler B, Meister E, Romero I, Couraud P, et al. Role of KCNMA1 gene in breast cancer invasion and metastasis to brain. BMC Cancer. 2009;9:258 pubmed publisher
    ..In this study we investigated the role of KCNMA1 gene that encodes for the pore-forming alpha-subunit of BKCa channels in breast cancer metastasis and invasion...
  6. Foutz R, Grimm P, Sansom S. Insulin increases the activity of mesangial BK channels through MAPK signaling. Am J Physiol Renal Physiol. 2008;294:F1465-72 pubmed publisher
    ..These results indicate that insulin activates BK in the plasma membrane of MC and stimulates, via MAPK, an increase in cellular and plasma membrane BK-alpha. ..
  7. Tomas M, Vazquez E, Fernández Fernández J, Subirana I, Plata C, Heras M, et al. Genetic variation in the KCNMA1 potassium channel alpha subunit as risk factor for severe essential hypertension and myocardial infarction. J Hypertens. 2008;26:2147-53 pubmed publisher
    ..We have studied polymorphisms in the pore-forming alpha subunit gene (KCNMA1) and their association to hypertension and myocardial infarction...
  8. Yang Y, Li P, Cheng J, Mao L, Wen J, Tan X, et al. Function of BKCa channels is reduced in human vascular smooth muscle cells from Han Chinese patients with hypertension. Hypertension. 2013;61:519-25 pubmed publisher
    ..This may account, at least in part, for the dysfunction of artery relaxation in Han Chinese patients with primary hypertension. ..
  9. Knaus H, Folander K, Garcia Calvo M, Garcia M, Kaczorowski G, Smith M, et al. Primary sequence and immunological characterization of beta-subunit of high conductance Ca(2+)-activated K+ channel from smooth muscle. J Biol Chem. 1994;269:17274-8 pubmed
    ..Furthermore, we demonstrate that the cloned protein is the subunit to which charybdotoxin is specifically and covalently incorporated when cross-linked to the channel. ..
  10. Meera P, Wallner M, Jiang Z, Toro L. A calcium switch for the functional coupling between alpha (hslo) and beta subunits (KV,Ca beta) of maxi K channels. FEBS Lett. 1996;382:84-8 pubmed
    KV,Ca beta subunit dramatically increases the apparent calcium sensitivity of the alpha subunit of MaxiK channels when probed in the micromolar [Ca2+]i range...
  11. Yan J, Aldrich R. LRRC26 auxiliary protein allows BK channel activation at resting voltage without calcium. Nature. 2010;466:513-6 pubmed publisher
  12. Carvacho I, Gonzalez W, Torres Y, Brauchi S, Alvarez O, Gonzalez Nilo F, et al. Intrinsic electrostatic potential in the BK channel pore: role in determining single channel conductance and block. J Gen Physiol. 2008;131:147-61 pubmed publisher
    ..contains a ring of eight negative charges not present in K(+) channels of lower conductance (Glu386 and Glu389 in hSlo) that modulates channel conductance through an electrostatic mechanism (Brelidze, T.I., X. Niu, and K.L. Magleby...
  13. Cambien B, Rezzonico R, Vitale S, Rouzaire Dubois B, Dubois J, Barthel R, et al. Silencing of hSlo potassium channels in human osteosarcoma cells promotes tumorigenesis. Int J Cancer. 2008;123:365-371 pubmed publisher
    ..Here, using stable RNA interference to reduce the expression of hSlo, the human pore-forming alpha-subunit of the BK channel, in human Cal72 OS cells, we show that BK channels play a ..
  14. Du W, Bautista J, Yang H, Diez Sampedro A, You S, Wang L, et al. Calcium-sensitive potassium channelopathy in human epilepsy and paroxysmal movement disorder. Nat Genet. 2005;37:733-8 pubmed
  15. Yan J, Aldrich R. BK potassium channel modulation by leucine-rich repeat-containing proteins. Proc Natl Acad Sci U S A. 2012;109:7917-22 pubmed publisher
  16. Kim E, Alvarez Baron C, Dryer S. Canonical transient receptor potential channel (TRPC)3 and TRPC6 associate with large-conductance Ca2+-activated K+ (BKCa) channels: role in BKCa trafficking to the surface of cultured podocytes. Mol Pharmacol. 2009;75:466-77 pubmed publisher
    Large-conductance (BK(Ca) type) Ca(2+)-activated K(+) channels encoded by the Slo1 gene and various canonical transient receptor potential channels (TRPCs) are coexpressed in many cell types, including podocytes (visceral epithelial cells)..
  17. Tang X, Xu R, Reynolds M, Garcia M, Heinemann S, Hoshi T. Haem can bind to and inhibit mammalian calcium-dependent Slo1 BK channels. Nature. 2003;425:531-5 pubmed
    ..A class of ion channel, the large-conductance calcium-dependent Slo1 BK channels, possesses a conserved haem-binding sequence motif...
  18. Brenner R, Jegla T, Wickenden A, Liu Y, Aldrich R. Cloning and functional characterization of novel large conductance calcium-activated potassium channel beta subunits, hKCNMB3 and hKCNMB4. J Biol Chem. 2000;275:6453-61 pubmed
    ..Although we found that hKCNMB3 does interact with Hslo channels, its effects on Hslo1 channel properties were slight, increasing Hslo1 activation rates...
  19. Wu Y, Yang Y, Ye S, Jiang Y. Structure of the gating ring from the human large-conductance Ca(2+)-gated K(+) channel. Nature. 2010;466:393-7 pubmed publisher
  20. Wallner M, Meera P, Toro L. Determinant for beta-subunit regulation in high-conductance voltage-activated and Ca(2+)-sensitive K+ channels: an additional transmembrane region at the N terminus. Proc Natl Acad Sci U S A. 1996;93:14922-7 pubmed
    The pore-forming alpha subunit of large conductance voltage- and Ca(2+)-sensitive K (MaxiK) channels is regulated by a beta subunit that has two membrane-spanning regions separated by an extracellular loop...
  21. Wang L, Sigworth F. Structure of the BK potassium channel in a lipid membrane from electron cryomicroscopy. Nature. 2009;461:292-5 pubmed publisher
    ..7-2.0 nm. Not requiring the formation of crystals, the RSC approach promises to be useful in the structural study of many other membrane proteins as well. ..
  22. Yuan C, O Connell R, Wilson A, Pietrzykowski A, Treistman S. Acute alcohol tolerance is intrinsic to the BKCa protein, but is modulated by the lipid environment. J Biol Chem. 2008;283:5090-8 pubmed
    ..As a consequence of these findings the protein-lipid complex should be treated as a unit when studying ethanol action. ..
  23. Valverde M, Rojas P, Amigo J, Cosmelli D, Orio P, Bahamonde M, et al. Acute activation of Maxi-K channels (hSlo) by estradiol binding to the beta subunit. Science. 1999;285:1929-31 pubmed
    ..Estradiol bound to the beta subunit and activated the Maxi-K channel (hSlo) only when both alpha and beta subunits were present...
  24. Bloch M, Ousingsawat J, Simon R, Schraml P, Gasser T, Mihatsch M, et al. KCNMA1 gene amplification promotes tumor cell proliferation in human prostate cancer. Oncogene. 2007;26:2525-34 pubmed
    ..Here, we studied gene amplification of the large conductance calcium-activated potassium channel alpha subunit (KCNMA1), which is located at the chromosomal region 10q22...
  25. Oeggerli M, Tian Y, Ruiz C, Wijker B, Sauter G, Obermann E, et al. Role of KCNMA1 in breast cancer. PLoS ONE. 2012;7:e41664 pubmed publisher
    b>KCNMA1 encodes the ?-subunit of the large conductance, voltage and Ca(2+)-activated (BK) potassium channel and has been reported as a target gene of genomic amplification at 10q22 in prostate cancer...
  26. Hou S, Vigeland L, Zhang G, Xu R, Li M, Heinemann S, et al. Zn2+ activates large conductance Ca2+-activated K+ channel via an intracellular domain. J Biol Chem. 2010;285:6434-42 pubmed publisher
    ..here that intracellular Zn(2+) potently and reversibly activates large-conductance voltage- and Ca(2+)-activated Slo1 K(+) (BK) channels...
  27. O Connell R, Yuan C, Johnston L, Rinco O, Probodh I, Treistman S. Gating and conductance changes in BK(Ca) channels in bilayers are reciprocal. J Membr Biol. 2006;213:143-53 pubmed
    ..We examined the single-channel conductance (G(c)) and gating (open probability, P (o)) of single BK(Ca) channels (hslo alpha-subunits) inserted into planar lipid bilayers containing 1,2-dioleoyl-3-phosphatidylethanolamine (DOPE) or ..
  28. Davies K, Zhao W, Tar M, Figueroa J, Desai P, Verselis V, et al. Diabetes-induced changes in the alternative splicing of the slo gene in corporal tissue. Eur Urol. 2007;52:1229-37 pubmed
    Erectile dysfunction is a common diabetic complication. Preclinical studies have documented that the Slo gene (encoding the BK or Maxi-K channel alpha-subunit) plays a critical role in erectile function...
  29. Wallner M, Meera P, Ottolia M, Kaczorowski G, Latorre R, Garcia M, et al. Characterization of and modulation by a beta-subunit of a human maxi KCa channel cloned from myometrium. Receptors Channels. 1995;3:185-99 pubmed
    cDNAs encoding functional maxi KCa channel alpha-subunits (hslo) were cloned from human myometrium. Northern blot analysis revealed a high abundance of mRNA in human uterine smooth muscle...
  30. Meera P, Wallner M, Song M, Toro L. Large conductance voltage- and calcium-dependent K+ channel, a distinct member of voltage-dependent ion channels with seven N-terminal transmembrane segments (S0-S6), an extracellular N terminus, and an intracellular (S9-S10) C terminus. Proc Natl Acad Sci U S A. 1997;94:14066-71 pubmed
    Large conductance voltage- and Ca2+-dependent K+ (MaxiK) channels show sequence similarities to voltage-gated ion channels. They have a homologous S1-S6 region, but are unique at the N and C termini...
  31. Yuan P, Leonetti M, Pico A, Hsiung Y, MacKinnon R. Structure of the human BK channel Ca2+-activation apparatus at 3.0 A resolution. Science. 2010;329:182-6 pubmed publisher
    ..The structure suggests that the Ca2+ gating ring, in addition to regulating the pore directly, may also modulate the voltage sensor. ..
  32. Butler A, Tsunoda S, McCobb D, Wei A, Salkoff L. mSlo, a complex mouse gene encoding "maxi" calcium-activated potassium channels. Science. 1993;261:221-4 pubmed
    ..A large number of variant mSlo cDNAs were isolated, indicating that several diverse mammalian BK channel types are produced by a single gene. ..
  33. Hu X, Laragione T, Sun L, Koshy S, Jones K, Ismailov I, et al. KCa1.1 potassium channels regulate key proinflammatory and invasive properties of fibroblast-like synoviocytes in rheumatoid arthritis. J Biol Chem. 2012;287:4014-22 pubmed publisher
    ..We have identified the calcium- and voltage-gated KCa1.1 channel (BK, Maxi-K, Slo1, KCNMA1) as the major potassium channel expressed at the plasma membrane of FLS isolated from patients with RA (RA-FLS)...
  34. Zarei M, Song M, Wilson R, Cox N, Colom L, Knaus H, et al. Endocytic trafficking signals in KCNMB2 regulate surface expression of a large conductance voltage and Ca(2+)-activated K+ channel. Neuroscience. 2007;147:80-9 pubmed
    ..with the human pore-forming alpha subunit of the large conductance voltage and Ca(2+)-activated K(+) channel (hSlo) yields inactivating currents similar to those observed in hippocampal neurons [Hicks GA, Marrion NV (1998) Ca(2+)-..
  35. Chen L, Tian L, MacDonald S, McClafferty H, Hammond M, Huibant J, et al. Functionally diverse complement of large conductance calcium- and voltage-activated potassium channel (BK) alpha-subunits generated from a single site of splicing. J Biol Chem. 2005;280:33599-609 pubmed
  36. Tian L, Coghill L, McClafferty H, MacDonald S, Antoni F, Ruth P, et al. Distinct stoichiometry of BKCa channel tetramer phosphorylation specifies channel activation and inhibition by cAMP-dependent protein kinase. Proc Natl Acad Sci U S A. 2004;101:11897-902 pubmed
    ..This essentially digital regulation has important implications for the combinatorial and conditional regulation of BK(Ca) channels by reversible protein phosphorylation. ..
  37. Savalli N, Kondratiev A, Toro L, Olcese R. Voltage-dependent conformational changes in human Ca(2+)- and voltage-activated K(+) channel, revealed by voltage-clamp fluorometry. Proc Natl Acad Sci U S A. 2006;103:12619-24 pubmed
    ..Extremely slow conformational changes were revealed by fluorescent labeling of position 202, elicited by a mutual interaction of the fluorophore with the adjacent tryptophan 203. ..
  38. Wei A, Gutman G, Aldrich R, Chandy K, Grissmer S, Wulff H. International Union of Pharmacology. LII. Nomenclature and molecular relationships of calcium-activated potassium channels. Pharmacol Rev. 2005;57:463-72 pubmed
  39. Wallner M, Meera P, Toro L. Molecular basis of fast inactivation in voltage and Ca2+-activated K+ channels: a transmembrane beta-subunit homolog. Proc Natl Acad Sci U S A. 1999;96:4137-42 pubmed
    Voltage-dependent and calcium-sensitive K+ (MaxiK) channels are key regulators of neuronal excitability, secretion, and vascular tone because of their ability to sense transmembrane voltage and intracellular Ca2+...
  40. Yusifov T, Javaherian A, Pantazis A, Gandhi C, Olcese R. The RCK1 domain of the human BKCa channel transduces Ca2+ binding into structural rearrangements. J Gen Physiol. 2010;136:189-202 pubmed publisher
    ..We provide evidence that the RCK1 domain is a high-affinity Ca(2+) sensor that transduces Ca(2+) binding into structural rearrangements, likely representing elementary steps in the Ca(2+)-dependent activation of human BK(Ca) channels. ..
  41. Harder A. The Biochemistry of Haemonchus contortus and Other Parasitic Nematodes. Adv Parasitol. 2016;93:69-94 pubmed publisher
    ..For example, the calcium- and voltage-dependent potassium channel SLO-1 is an important target of emodepside, which is involved in the sensitive regulation of activatory and inhibitory ..
  42. Gambade A, Zreika S, Guéguinou M, Chourpa I, Fromont G, Bouchet A, et al. Activation of TRPV2 and BKCa channels by the LL-37 enantiomers stimulates calcium entry and migration of cancer cells. Oncotarget. 2016;7:23785-800 pubmed publisher
    ..LL-37 attached to caveolae and pseudopodia membranes and decreased membrane fluidity, suggesting that a modification of the physical properties of the lipid membrane bilayer was the underlying mechanism of its effects. ..
  43. Shi P, Li D, Lai C, Zhang L, Tian C. Intracellular segment between transmembrane helices S0 and S1 of BK channel ? subunit contains two amphipathic helices connected by a flexible loop. Biochem Biophys Res Commun. 2013;437:408-12 pubmed publisher
    ..Two residues (Thr45 and Leu46) with chemical shift changes were observed but no, or very minor, chemical shift difference was observed for Asp99, indicating a possible site for binding divalent ions or other modulation partners. ..
  44. Kim H, Oh K. Protein Network Interacting with BK Channels. Int Rev Neurobiol. 2016;128:127-61 pubmed publisher
    The large conductance, voltage- and calcium-dependent potassium BK channel, also termed BKCa, Maxi-K, KCa1.1, or SLO1, regulates a wide array of key biological processes that are mediated by calcium ions...
  45. Shoji A, Ikeya K, Aoyagi M, Takatsuji R, Yanagida A, Shibusawa Y, et al. Monitoring of cholesterol oxidation in a lipid bilayer membrane using streptolysin O as a sensing and signal transduction element. J Pharm Biomed Anal. 2016;128:455-461 pubmed publisher
    Streptolysin O (SLO), which recognizes sterols and forms nanopores in lipid membranes, is proposed as a sensing element for monitoring cholesterol oxidation in a lipid bilayer...
  46. Liu Q, Williams D, McManus C, Baribaud F, Doms R, Schols D, et al. HIV-1 gp120 and chemokines activate ion channels in primary macrophages through CCR5 and CXCR4 stimulation. Proc Natl Acad Sci U S A. 2000;97:4832-7 pubmed
    ..Intracellular signaling responses of macrophages to HIV-1 may modulate postentry steps of infection and cell functions apart from infection. ..
  47. Korovkina V, Fergus D, Holdiman A, England S. Characterization of a novel 132-bp exon of the human maxi-K channel. Am J Physiol Cell Physiol. 2001;281:C361-7 pubmed
    ..Alternative splicing to introduce this 132-bp exon into the maxi-K channel may elicit another mode to modulate cell excitability...
  48. Hartness M, Brazier S, Peers C, Bateson A, Ashford M, Kemp P. Post-transcriptional control of human maxiK potassium channel activity and acute oxygen sensitivity by chronic hypoxia. J Biol Chem. 2003;278:51422-32 pubmed
    ..Central to many affected excitable tissues is activity of large conductance, Ca2+-activated K+ (maxiK) channels...
  49. Morrison A, Felix J, Cupples L, Glazer N, Loehr L, Dehghan A, et al. Genomic variation associated with mortality among adults of European and African ancestry with heart failure: the cohorts for heart and aging research in genomic epidemiology consortium. Circ Cardiovasc Genet. 2010;3:248-55 pubmed publisher
    ..This study identified a novel locus associated with all-cause mortality among individuals of European ancestry with HF. This finding warrants additional investigation, including replication, in other studies of HF. ..
  50. Alioua A, Mahajan A, Nishimaru K, Zarei M, Stefani E, Toro L. Coupling of c-Src to large conductance voltage- and Ca2+-activated K+ channels as a new mechanism of agonist-induced vasoconstriction. Proc Natl Acad Sci U S A. 2002;99:14560-5 pubmed
    The voltage-dependent and Ca(2+)-activated K(+) channel (MaxiK, BK) and the cellular proto-oncogene pp60(c-Src) (c-Src) are abundant proteins in vascular smooth muscle...
  51. da Rosa Maggi Sant Helena B, Guarido K, de Souza P, Crestani S, da Silva Santos J. Reduction in renal blood flow following administration of norepinephrine and phenylephrine in septic rats treated with Kir6.1 ATP-sensitive and KCa1.1 calcium-activated K+ channel blockers. Eur J Pharmacol. 2015;765:42-50 pubmed publisher
  52. Tajhya R, Hu X, Tanner M, Huq R, Kongchan N, Neilson J, et al. Functional KCa1.1 channels are crucial for regulating the proliferation, migration and differentiation of human primary skeletal myoblasts. Cell Death Dis. 2016;7:e2426 pubmed publisher
    ..Here, we demonstrate that the calcium- and voltage-dependent potassium channel, KCa1.1 (BK, Slo1, KCNMA1), regulates myoblast proliferation, migration, and fusion...
  53. Laslandes M, Salas M, Hitzenberger C, Pircher M. Increasing the field of view of adaptive optics scanning laser ophthalmoscopy. Biomed Opt Express. 2017;8:4811-4826 pubmed publisher
    An adaptive optics scanning laser ophthalmoscope (AO-SLO) set-up with two deformable mirrors (DM) is presented...
  54. Li N, Liu L, Li G, Xia M, Du C, Zheng Z. The role of BKCa in endometrial cancer HEC-1-B cell proliferation and migration. Gene. 2018;655:42-47 pubmed publisher
    ..In summary, these data suggested an important role of BKCa in proliferation and migration of endometrial cancer HEC-1-B cells. Thus, BKCa may be established as a potential therapeutic target in endometrial cancer. ..
  55. Rabjerg M. Identification and validation of novel prognostic markers in Renal Cell Carcinoma. Dan Med J. 2017;64: pubmed
    ..Future research initiatives based on the results presented in this thesis could clarify the potential role of CX-4945 as a novel targeted treatment of ccRCC patients...
  56. Fernández Fernández J, Andrade Y, Arniges M, Fernandes J, Plata C, Rubio Moscardo F, et al. Functional coupling of TRPV4 cationic channel and large conductance, calcium-dependent potassium channel in human bronchial epithelial cell lines. Pflugers Arch. 2008;457:149-59 pubmed publisher
  57. Pallanck L, Ganetzky B. Cloning and characterization of human and mouse homologs of the Drosophila calcium-activated potassium channel gene, slowpoke. Hum Mol Genet. 1994;3:1239-43 pubmed
  58. Gessner G, Cui Y, Otani Y, Ohwada T, Soom M, Hoshi T, et al. Molecular mechanism of pharmacological activation of BK channels. Proc Natl Acad Sci U S A. 2012;109:3552-7 pubmed publisher
    Large-conductance voltage- and Ca(2+)-activated K(+) (Slo1 BK) channels serve numerous cellular functions, and their dysregulation is implicated in various diseases...
  59. Fezai M, Ahmed M, Hosseinzadeh Z, Lang F. Up-Regulation of the Large-Conductance Ca2+-Activated K+ Channel by Glycogen Synthase Kinase GSK3?. Cell Physiol Biochem. 2016;39:1031-9 pubmed publisher
    ..GSK3ß may up-regulate BK channels, an effect disrupted by Lithium or additional expression of PKB and possibly participating in the regulation of cell volume and excitability. ..
  60. Bell B, Yuan A, DiCicco R, Fogerty J, Lessieur E, Perkins B. The adult zebrafish retina: In vivo optical sectioning with Confocal Scanning Laser Ophthalmoscopy and Spectral-Domain Optical Coherence Tomography. Exp Eye Res. 2016;153:65-78 pubmed publisher
    ..Two imaging devices, the scanning laser ophthalmoscope (SLO) and spectral domain optical coherence tomography (SDOCT), emerged from the clinical realm to provide research ..
  61. Jamnikar Ciglenecki U, Kuhar U, Steyer A, Kirbis A. Whole genome sequence and a phylogenetic analysis of the G8P[14] group A rotavirus strain from roe deer. BMC Vet Res. 2017;13:353 pubmed publisher
    ..A further RVA strain (SLO/D110-15) was detected from a roe deer during 2015...
  62. Tseng Crank J, Foster C, Krause J, Mertz R, Godinot N, DiChiara T, et al. Cloning, expression, and distribution of functionally distinct Ca(2+)-activated K+ channel isoforms from human brain. Neuron. 1994;13:1315-30 pubmed
    ..All isoforms are generated by alternative RNA splicing of a single gene on chromosome 10 at band q22.3 (hslo)...
  63. Mazar J, DeYoung K, Khaitan D, Meister E, Almodovar A, Goydos J, et al. The regulation of miRNA-211 expression and its role in melanoma cell invasiveness. PLoS ONE. 2010;5:e13779 pubmed publisher
    ..In vivo target cleavage assays confirmed one such target mRNA encoded by KCNMA1. Mutating the miR-211 binding site seed sequences at the KCNMA1 3'-UTR abolished target cleavage...
  64. Tabarki B, AlMajhad N, Alhashem A, Shaheen R, Alkuraya F. Homozygous KCNMA1 mutation as a cause of cerebellar atrophy, developmental delay and seizures. Hum Genet. 2016;135:1295-1298 pubmed
    Dominant gain-of-function mutations of the KCNMA1 gene, encoding the pore-forming subunit of the large conductance voltage- and Ca2+-activated K+ channel, have been described in a few patients with the syndrome of epilepsy, ..
  65. Dismuke W, Mbadugha C, Ellis D. NO-induced regulation of human trabecular meshwork cell volume and aqueous humor outflow facility involve the BKCa ion channel. Am J Physiol Cell Physiol. 2008;294:C1378-86 pubmed publisher
    ..Additionally, the time course for NO-induced decreases in TM cell volume correlated with NO-induced increases in outflow facility, suggesting that the NO-induced alterations in cell volume may influence outflow facility. ..