KCNJ8

Summary

Gene Symbol: KCNJ8
Description: potassium voltage-gated channel subfamily J member 8
Alias: KIR6.1, uKATP-1, ATP-sensitive inward rectifier potassium channel 8, inward rectifier K(+) channel Kir6.1, inwardly rectifying potassium channel KIR6.1, potassium channel, inwardly rectifying subfamily J member 8, potassium inwardly-rectifying channel, subfamily J, member 8
Species: human
Products:     KCNJ8

Top Publications

  1. Shi Y, Cui N, Shi W, Jiang C. A short motif in Kir6.1 consisting of four phosphorylation repeats underlies the vascular KATP channel inhibition by protein kinase C. J Biol Chem. 2008;283:2488-94 pubmed
    ..1, but not in its close relative Kir6.2, suggests that the vascular K(ATP) channel may have undergone evolutionary optimization, allowing it to be regulated by a variety of vasoconstricting hormones and neurotransmitters...
  2. Curley M, Cairns M, Friel A, McMeel O, Morrison J, Smith T. Expression of mRNA transcripts for ATP-sensitive potassium channels in human myometrium. Mol Hum Reprod. 2002;8:941-5 pubmed
    ..05) were still observed. Our results indicate that the major K(ATP) channel expressed in human myometrium is composed of Kir6.1 and SUR2B, and that down-regulation of this channel may facilitate myometrial function during late pregnancy...
  3. Liu Y, Ren G, O ROURKE B, Marban E, Seharaseyon J. Pharmacological comparison of native mitochondrial K(ATP) channels with molecularly defined surface K(ATP) channels. Mol Pharmacol. 2001;59:225-30 pubmed
    ..5 microM), but was 67 times less potent in blocking Kir6.1/SUR1 channels (IC(50) = 100 microM). Our results demonstrate that mitoK(ATP) channels closely resemble Kir6.1/SUR1 sK(ATP) channels in their pharmacological profiles...
  4. Seino S. ATP-sensitive potassium channels: a model of heteromultimeric potassium channel/receptor assemblies. Annu Rev Physiol. 1999;61:337-62 pubmed
    ..Since 1995, molecular biological and molecular genetic studies of KATP channels have provided insights into the structure-function relationships, molecular regulation, and pathophysiological roles of KATP channels...
  5. Zhou M, Tanaka O, Sekiguchi M, He H, Yasuoka Y, Itoh H, et al. ATP-sensitive K+-channel subunits on the mitochondria and endoplasmic reticulum of rat cardiomyocytes. J Histochem Cytochem. 2005;53:1491-500 pubmed
    ..The data obtained in this study will be useful for analyzing the composition of K(ATP) channels of cardiomyocytes and help to understanding the cardioprotective role of K(ATP) channels during heart ischemia...
  6. Shi Y, Wu Z, Cui N, Shi W, Yang Y, Zhang X, et al. PKA phosphorylation of SUR2B subunit underscores vascular KATP channel activation by beta-adrenergic receptors. Am J Physiol Regul Integr Comp Physiol. 2007;293:R1205-14 pubmed
    ..Taken together, these results indicate that the Kir6.1/SUR2B channel is a target of beta(2) receptors and that the channel activation relies on PKA phosphorylation of SUR2B at Ser1387...
  7. Sudhir R, Sukhodub A, Du Q, Jovanovic S, Jovanovic A. Ageing-induced decline in physical endurance in mice is associated with decrease in cardiac SUR2A and increase in cardiac susceptibility to metabolic stress: therapeutic prospects for up-regulation of SUR2A. Biogerontology. 2011;12:147-55 pubmed publisher
  8. Lang V, Youssef N, Light P. The molecular genetics of sulfonylurea receptors in the pathogenesis and treatment of insulin secretory disorders and type 2 diabetes. Curr Diab Rep. 2011;11:543-51 pubmed publisher
    ..x) subunits encoded by the ABCC8/9 and KCNJ8/11 genes, respectively...
  9. Gasparotto Junior A, Dos Reis Piornedo R, Assreuy J, da Silva Santos J. Nitric oxide and Kir6.1 potassium channel mediate isoquercitrin-induced endothelium-dependent and independent vasodilation in the mesenteric arterial bed of rats. Eur J Pharmacol. 2016;788:328-334 pubmed publisher
    ..Our study shows that isoquercitrin induces vasodilation in resistance arteries, an effect mediated by K(+) channel opening and endothelial nitric oxide production. ..
  10. Kawano T, Oshita S, Takahashi A, Tsutsumi Y, Tomiyama Y, Kitahata H, et al. Molecular mechanisms of the inhibitory effects of propofol and thiamylal on sarcolemmal adenosine triphosphate-sensitive potassium channels. Anesthesiology. 2004;100:338-46 pubmed
    ..1 or Kir6.2) genes and sulfonylurea receptor (SUR1, SUR2A, or SUR2B) genes...

Detail Information

Publications104 found, 100 shown here

  1. Shi Y, Cui N, Shi W, Jiang C. A short motif in Kir6.1 consisting of four phosphorylation repeats underlies the vascular KATP channel inhibition by protein kinase C. J Biol Chem. 2008;283:2488-94 pubmed
    ..1, but not in its close relative Kir6.2, suggests that the vascular K(ATP) channel may have undergone evolutionary optimization, allowing it to be regulated by a variety of vasoconstricting hormones and neurotransmitters...
  2. Curley M, Cairns M, Friel A, McMeel O, Morrison J, Smith T. Expression of mRNA transcripts for ATP-sensitive potassium channels in human myometrium. Mol Hum Reprod. 2002;8:941-5 pubmed
    ..05) were still observed. Our results indicate that the major K(ATP) channel expressed in human myometrium is composed of Kir6.1 and SUR2B, and that down-regulation of this channel may facilitate myometrial function during late pregnancy...
  3. Liu Y, Ren G, O ROURKE B, Marban E, Seharaseyon J. Pharmacological comparison of native mitochondrial K(ATP) channels with molecularly defined surface K(ATP) channels. Mol Pharmacol. 2001;59:225-30 pubmed
    ..5 microM), but was 67 times less potent in blocking Kir6.1/SUR1 channels (IC(50) = 100 microM). Our results demonstrate that mitoK(ATP) channels closely resemble Kir6.1/SUR1 sK(ATP) channels in their pharmacological profiles...
  4. Seino S. ATP-sensitive potassium channels: a model of heteromultimeric potassium channel/receptor assemblies. Annu Rev Physiol. 1999;61:337-62 pubmed
    ..Since 1995, molecular biological and molecular genetic studies of KATP channels have provided insights into the structure-function relationships, molecular regulation, and pathophysiological roles of KATP channels...
  5. Zhou M, Tanaka O, Sekiguchi M, He H, Yasuoka Y, Itoh H, et al. ATP-sensitive K+-channel subunits on the mitochondria and endoplasmic reticulum of rat cardiomyocytes. J Histochem Cytochem. 2005;53:1491-500 pubmed
    ..The data obtained in this study will be useful for analyzing the composition of K(ATP) channels of cardiomyocytes and help to understanding the cardioprotective role of K(ATP) channels during heart ischemia...
  6. Shi Y, Wu Z, Cui N, Shi W, Yang Y, Zhang X, et al. PKA phosphorylation of SUR2B subunit underscores vascular KATP channel activation by beta-adrenergic receptors. Am J Physiol Regul Integr Comp Physiol. 2007;293:R1205-14 pubmed
    ..Taken together, these results indicate that the Kir6.1/SUR2B channel is a target of beta(2) receptors and that the channel activation relies on PKA phosphorylation of SUR2B at Ser1387...
  7. Sudhir R, Sukhodub A, Du Q, Jovanovic S, Jovanovic A. Ageing-induced decline in physical endurance in mice is associated with decrease in cardiac SUR2A and increase in cardiac susceptibility to metabolic stress: therapeutic prospects for up-regulation of SUR2A. Biogerontology. 2011;12:147-55 pubmed publisher
  8. Lang V, Youssef N, Light P. The molecular genetics of sulfonylurea receptors in the pathogenesis and treatment of insulin secretory disorders and type 2 diabetes. Curr Diab Rep. 2011;11:543-51 pubmed publisher
    ..x) subunits encoded by the ABCC8/9 and KCNJ8/11 genes, respectively...
  9. Gasparotto Junior A, Dos Reis Piornedo R, Assreuy J, da Silva Santos J. Nitric oxide and Kir6.1 potassium channel mediate isoquercitrin-induced endothelium-dependent and independent vasodilation in the mesenteric arterial bed of rats. Eur J Pharmacol. 2016;788:328-334 pubmed publisher
    ..Our study shows that isoquercitrin induces vasodilation in resistance arteries, an effect mediated by K(+) channel opening and endothelial nitric oxide production. ..
  10. Kawano T, Oshita S, Takahashi A, Tsutsumi Y, Tomiyama Y, Kitahata H, et al. Molecular mechanisms of the inhibitory effects of propofol and thiamylal on sarcolemmal adenosine triphosphate-sensitive potassium channels. Anesthesiology. 2004;100:338-46 pubmed
    ..1 or Kir6.2) genes and sulfonylurea receptor (SUR1, SUR2A, or SUR2B) genes...
  11. Bryan J, Munoz A, Zhang X, Dufer M, Drews G, Krippeit Drews P, et al. ABCC8 and ABCC9: ABC transporters that regulate K+ channels. Pflugers Arch. 2007;453:703-18 pubmed
    ..1/kcnj8 or k(ir)6...
  12. Shi W, Yang Y, Shi Y, Jiang C. K(ATP) channel action in vascular tone regulation: from genetics to diseases. Sheng Li Xue Bao. 2012;64:1-13 pubmed
  13. Delaney J, Muhammad R, Blair M, Kor K, Fish F, Roden D, et al. A KCNJ8 mutation associated with early repolarization and atrial fibrillation. Europace. 2012;14:1428-32 pubmed
    ..from both functional and genetic studies of the potassium inwardly-rectifying channel, subfamily J, member 8 (KCNJ8)-S422L missense mutation in patients with J-wave syndromes. Although Kir6...
  14. Fan Y, Kong H, Ye X, Ding J, Hu G. ATP-sensitive potassium channels: uncovering novel targets for treating depression. Brain Struct Funct. 2016;221:3111-22 pubmed publisher
    ..2(-/-) mice. Collectively, our findings demonstrate that K-ATP channels are involved in the pathogenesis of depression and may be a promising target for the therapy of depression. ..
  15. Warnecke Eberz U, Metzger R, Hölscher A, Drebber U, Bollschweiler E. Diagnostic marker signature for esophageal cancer from transcriptome analysis. Tumour Biol. 2016;37:6349-58 pubmed publisher
    ..clustered in a "diagnostic signature": PLA2G7, PRAME, MMP1, MMP3, MMP12, LIlRB2, TREM2, CHST2, IGFBP2, IGFBP7, KCNJ8, EMILIN2, CTHRC1, EMR2, WDR72, LPCAT1, COL4A2, CCL4, and SNX10...
  16. Zhang H, Flagg T, Nichols C. Cardiac sarcolemmal K(ATP) channels: Latest twists in a questing tale!. J Mol Cell Cardiol. 2010;48:71-5 pubmed publisher
    ..1, KCNJ8, and Kir6...
  17. Diehlmann A, Bork S, Saffrich R, Veh R, Wagner W, Derst C. KATP channels in mesenchymal stromal stem cells: strong up-regulation of Kir6.2 subunits upon osteogenic differentiation. Tissue Cell. 2011;43:331-6 pubmed publisher
    ..2 upon osteogenic differentiation. Taken together, expression changes of K(ATP) channels may contribute to in vitro differentiation of MSC and represent changes in the metabolic state of the developing tissue...
  18. Vezir O, Comelekoglu U, Sucu N, Yalin A, Yılmaz Ş, Yalin S, et al. N-Acetylcysteine-induced vasodilatation is modulated by KATP channels, Na+/K+-ATPase activity and intracellular calcium concentration: An in vitro study. Pharmacol Rep. 2017;69:738-745 pubmed publisher
    ..channel, the concentration of intracellular calcium and mRNA expression level of KATP channel subunits (KCNJ8, KCNJ11, ABCC8 and ABCC9). The relaxation rate significantly increased in all NAC groups compared to control...
  19. Akao M, Otani H, Horie M, Takano M, Kuniyasu A, Nakayama H, et al. Myocardial ischemia induces differential regulation of KATP channel gene expression in rat hearts. J Clin Invest. 1997;100:3053-9 pubmed
    ..2-fold) region of rat hearts subjected to 60 min of ischemia followed by 24 h of reperfusion. Thus, prolonged myocardial ischemia rather than reperfusion induces delayed and differential regulation of cardiac KATP channel gene expression...
  20. Seino S. Physiology and pathophysiology of K(ATP) channels in the pancreas and cardiovascular system: a review. J Diabetes Complications. 2003;17:2-5 pubmed
    ..1 rather than Kir6.2 is critical in the regulation of vascular tone. This article summarizes current understanding of the physiology and pathophysiology of Kir6.1- and Kir6.2-containing K(ATP) channels...
  21. Kubo Y, Adelman J, Clapham D, Jan L, Karschin A, Kurachi Y, et al. International Union of Pharmacology. LIV. Nomenclature and molecular relationships of inwardly rectifying potassium channels. Pharmacol Rev. 2005;57:509-26 pubmed
  22. Shi W, Cui N, Wu Z, Yang Y, Zhang S, Gai H, et al. Lipopolysaccharides up-regulate Kir6.1/SUR2B channel expression and enhance vascular KATP channel activity via NF-kappaB-dependent signaling. J Biol Chem. 2010;285:3021-9 pubmed publisher
    ..1 and SUR2B expression to a similar degree as LPS. Thus, the effect of LPS on vasodilation involves up-regulation of K(ATP) channel expression, in which the NF-kappaB-dependent signaling plays an important role. ..
  23. Levin M, Singh G, Zhang H, Uchida K, Kozel B, Stein P, et al. K(ATP) channel gain-of-function leads to increased myocardial L-type Ca(2+) current and contractility in Cantu syndrome. Proc Natl Acad Sci U S A. 2016;113:6773-8 pubmed publisher
    Cantu syndrome (CS) is caused by gain-of-function (GOF) mutations in genes encoding pore-forming (Kir6.1, KCNJ8) and accessory (SUR2, ABCC9) KATP channel subunits...
  24. Bal R, Ozturk G, Etem E, Him A, Cengiz N, Kuloglu T, et al. Modulation of Excitability of Stellate Neurons in the Ventral Cochlear Nucleus of Mice by ATP-Sensitive Potassium Channels. J Membr Biol. 2018;251:163-178 pubmed publisher
    ..2 subunit and SUR1 and SUR2 and activation or inhibition of KATP channels regulates firing properties of stellate cells by means of influencing resting membrane potential and input resistance. ..
  25. Zhou M, He H, Tanaka O, Suzuki R, Sekiguchi M, Yasuoka Y, et al. Localization of the sulphonylurea receptor subunits, SUR2A and SUR2B, in rat renal tubular epithelium. Tohoku J Exp Med. 2008;214:247-56 pubmed
    ..In conclusion, the regulatory subunits of the K(ATP) channel in the rat kidney are SUR2A and SUR2B; they also are candidate regulatory subunits for the mitochondrial K(ATP) channel...
  26. Fan L, Tian H, Wang J, Huo J, Hu Z, Ma A, et al. Downregulation of Kir6.1/SUR2B channels in the obese rat aorta. Nutrition. 2009;25:359-63 pubmed publisher
    ..This study was designed to evaluate the contribution of adenosine triphosphate-dependent potassium channels to the increase in blood pressure observed in obese rats...
  27. Benamer N, Fares N, Bois P, Faivre J. Electrophysiological and functional effects of sphingosine-1-phosphate in mouse ventricular fibroblasts. Biochem Biophys Res Commun. 2011;408:6-11 pubmed publisher
    ..1 channel. The latter effect occurs after fibroblasts differentiate into myofibroblasts, opening a new potential therapeutic strategy to modulate fibrosis after cardiac physiopathological injury...
  28. Kim D, Kim I, Papreck J, Donnelly D, Carroll J. Characterization of an ATP-sensitive K(+) channel in rat carotid body glomus cells. Respir Physiol Neurobiol. 2011;177:247-55 pubmed publisher
    ..These results show that an ATP-sensitive K(+) channel is expressed in the plasma membrane of CB cells, but is not activated by short-term metabolic inhibition. The functional relevance of the 72-pS channel remains to be determined...
  29. Henn M, Janjua M, Zhang H, Kanter E, Makepeace C, Schuessler R, et al. Increased tolerance to stress in cardiac expressed gain-of-function of adenosine triphosphate-sensitive potassium channel subunit Kir6.1. J Surg Res. 2016;206:460-465 pubmed publisher
    ..Understanding the role of Kir6.1 in myocyte response to stress may aid in the treatment of patients with Cantu syndrome and warrants further investigation. ..
  30. Brochiero E, Wallendorf B, Gagnon D, Laprade R, Lapointe J. Cloning of rabbit Kir6.1, SUR2A, and SUR2B: possible candidates for a renal K(ATP) channel. Am J Physiol Renal Physiol. 2002;282:F289-300 pubmed
    ..x with or without the SUR subunit were significantly inhibited by taurine. This study suggests that the taurine-sensitive K(ATP) channel of rabbit proximal tubules is formed by a combination of Kir6.1 plus SUR2A and/or SUR2B...
  31. López Alonso J, de Araujo E, Kanelis V. NMR and fluorescence studies of drug binding to the first nucleotide binding domain of SUR2A. Biochemistry. 2012;51:9211-22 pubmed publisher
    ..These studies identify additional binding sites for commonly used KCOs and provide a foundation for testing binding of drugs to the SUR NBDs...
  32. Nichols C. Adenosine Triphosphate-Sensitive Potassium Currents in Heart Disease and Cardioprotection. Card Electrophysiol Clin. 2016;8:323-35 pubmed publisher
  33. Cooper P, McClenaghan C, Chen X, Stary Weinzinger A, Nichols C. Conserved functional consequences of disease-associated mutations in the slide helix of Kir6.1 and Kir6.2 subunits of the ATP-sensitive potassium channel. J Biol Chem. 2017;292:17387-17398 pubmed publisher
    ..1 (KCNJ8) subunit...
  34. Flagg T, Enkvetchakul D, Koster J, Nichols C. Muscle KATP channels: recent insights to energy sensing and myoprotection. Physiol Rev. 2010;90:799-829 pubmed publisher
    ..As yet, few human diseases have been correlated with altered muscle K(ATP) activity, but genetically modified animals give important insights to likely pathological roles of aberrant channel activity in different muscle types...
  35. Mathias R, von der Weid P. Involvement of the NO-cGMP-K(ATP) channel pathway in the mesenteric lymphatic pump dysfunction observed in the guinea pig model of TNBS-induced ileitis. Am J Physiol Gastrointest Liver Physiol. 2013;304:G623-34 pubmed publisher
    ..Our findings suggest that NO and K(ATP) play a major role in the lymphatic contractile dysfunction that occurred as a consequence of the intestinal inflammation caused by TNBS...
  36. Newfield R. Topical sulfonylurea as a novel therapy for hypertrichosis secondary to diazoxide, and potentially for other conditions with excess hair growth. Med Hypotheses. 2015;85:969-71 pubmed publisher
    ..can also be applied to rare cases of Cantú syndrome, caused by mutations in ABCC9 (coding for SUR2) or in KCNJ8 (coding for Kir6.1) that is characterized by congenital hypertrichosis...
  37. Li C, Cui W, Wang H. Sensitivity of KATP channels to cellular metabolic disorders and the underlying structural basis. Acta Pharmacol Sin. 2016;37:134-42 pubmed publisher
    ..1 subunit, has intrinsic sensitivity to cell metabolic disorders. The residues (K707 and K1348) within the WA motifs of SUR2B are important for the sensitivity of SUR2B/Kir6.x channels to cell metabolic disorders. ..
  38. Lacza Z, Snipes J, Miller A, Szabo C, Grover G, Busija D. Heart mitochondria contain functional ATP-dependent K+ channels. J Mol Cell Cardiol. 2003;35:1339-47 pubmed
    ..We conclude that a functional K(ATP) channel is present in heart mitochondria, which can be opened by diazoxide or BMS-191095. The channel can be composed of Kir6.1 and Kir6.2 subunits and does not contain either SUR1 or SUR2...
  39. Wang S, Long C, Chen J, Cui W, Zhang Y, Zhang H, et al. Pharmacological evidence: a new therapeutic approach to the treatment of chronic heart failure through SUR2B/Kir6.1 channel in endothelial cells. Acta Pharmacol Sin. 2017;38:41-55 pubmed publisher
    ..This study demonstrates a new pharmacological approach to the treatment of CHF through activation of the SUR2B/Kir6.1 channel in endothelial cells, and that the eNOS/VASP pathways are involved in its signaling mechanisms. ..
  40. Inagaki N, Tsuura Y, Namba N, Masuda K, Gonoi T, Horie M, et al. Cloning and functional characterization of a novel ATP-sensitive potassium channel ubiquitously expressed in rat tissues, including pancreatic islets, pituitary, skeletal muscle, and heart. J Biol Chem. 1995;270:5691-4 pubmed
  41. Emanuele E, Falcone C, Carabela M, Minoretti P, D Angelo A, Montagna L, et al. Absence of Kir6.1/KCNJ8 mutations in Italian patients with abnormal coronary vasomotion. Int J Mol Med. 2003;12:509-12 pubmed
    ..A mouse model of human variant (vasospastic) angina has been recently obtained by disruption of Kir6.1/Kcnj8, a gene coding for a small pore-forming inward rectifier potassium channel...
  42. Hong S, Kyeong K, Kim C, Kim Y, Choi W, Yoo R, et al. Regulation of myometrial contraction by ATP-sensitive potassium (KATP) channel via activation of SUR2B and Kir 6.2 in mouse. J Vet Med Sci. 2016;78:1153-9 pubmed publisher
    ..2. Based on the modulatory effects of the KATP channel on spontaneous contraction, OXT- and PGF2?-induced contractions, KATP channels seem to play an essential role in murine myometrial motility via activation of SUR2B and Kir6.2. ..
  43. Schwanstecher M, Sieverding C, Dorschner H, Gross I, Aguilar Bryan L, Schwanstecher C, et al. Potassium channel openers require ATP to bind to and act through sulfonylurea receptors. EMBO J. 1998;17:5529-35 pubmed
    ..2 channels. The results establish that SURs are the KCO receptors of KATP channels and suggest that KCO binding requires a conformational change induced by ATP hydrolysis in both NBFs...
  44. Tucker S, Ashcroft F. Mapping of the physical interaction between the intracellular domains of an inwardly rectifying potassium channel, Kir6.2. J Biol Chem. 1999;274:33393-7 pubmed
    ..2 and Kir2.1 to form functional channels, suggesting that this interaction may be a feature common to all members of the Kir family of potassium channels. ..
  45. Horinaka S, Kobayashi N, Higashi T, Hara K, Hara S, Matsuoka H. Nicorandil enhances cardiac endothelial nitric oxide synthase expression via activation of adenosine triphosphate-sensitive K channel in rat. J Cardiovasc Pharmacol. 2001;38:200-10 pubmed
    ..Nicorandil appears to enhance cardiac eNOS expression via activation of a K(ATP) channel...
  46. Jöns T, Wittschieber D, Beyer A, Meier C, Brune A, Thomzig A, et al. K+-ATP-channel-related protein complexes: potential transducers in the regulation of epithelial tight junction permeability. J Cell Sci. 2006;119:3087-97 pubmed
    ..The data presented here shed new light on the physiological and pathophysiological role K(+)-ATP channels might have for the regulation of tight junctions...
  47. Tomita H, Sasaki S, Osanai T, Nakano T, Higuma T, Yokoyama J, et al. Mutational analysis of Kir6.1 in Japanese patients with coronary spastic angina. Int J Mol Med. 2006;18:589-91 pubmed
    ..No mutation that alters primary structure of Kir6.1 was detected in Japanese patients with CSA. The results indicate that abnormality in the primary structure of Kir6.1 may not be involved in the genetic pathogenesis of CSA in humans. ..
  48. Ellis J, Lamantia A, Chavez R, Scurrah K, Nichols C, Harrap S. Genes controlling postural changes in blood pressure: comprehensive association analysis of ATP-sensitive potassium channel genes KCNJ8 and ABCC9. Physiol Genomics. 2010;40:184-8 pubmed publisher
    ..Our genomewide linkage analysis suggests a region on chromosome 12p that harbors two strong candidate genes, KCNJ8 and ABCC9, encoding the channel-forming inward rectifier subunit Kir6...
  49. Olson T, Terzic A. Human K(ATP) channelopathies: diseases of metabolic homeostasis. Pflugers Arch. 2010;460:295-306 pubmed publisher
    ..Thus, advances in molecular medicine in the emerging field of human KATP channelopathies offer new opportunities for targeted individualized screening, early diagnosis, and tailored therapy...
  50. Medeiros Domingo A, Tan B, Crotti L, Tester D, Eckhardt L, Cuoretti A, et al. Gain-of-function mutation S422L in the KCNJ8-encoded cardiac K(ATP) channel Kir6.1 as a pathogenic substrate for J-wave syndromes. Heart Rhythm. 2010;7:1466-71 pubmed publisher
    ..b>KCNJ8, which encodes the cardiac K(ATP) Kir6...
  51. Du Q, Jovanovic S, Sukhodub A, Barratt E, Drew E, Whalley K, et al. Human oocytes express ATP-sensitive K(+) channels. Hum Reprod. 2010;25:2774-82 pubmed publisher
    ..x (Kir6.1 or Kir6.2) and regulatory, SURx (SUR2A, SUR2B or SUR1), subunits that associate in different combinations. The objective of this study was to determine whether mammalian oocytes (human, bovine, porcine) express K(ATP) channels...
  52. Surah Narwal S, Xu S, McHugh D, McDonald R, Hough E, Cheong A, et al. Block of human aorta Kir6.1 by the vascular KATP channel inhibitor U37883A. Br J Pharmacol. 1999;128:667-72 pubmed
  53. Sampson L, Hayabuchi Y, Standen N, Dart C. Caveolae localize protein kinase A signaling to arterial ATP-sensitive potassium channels. Circ Res. 2004;95:1012-8 pubmed
  54. Blanco Rivero J, Gamallo C, Aras Lopez R, Cobeño L, Cogolludo A, Perez Vizcaino F, et al. Decreased expression of aortic KIR6.1 and SUR2B in hypertension does not correlate with changes in the functional role of K(ATP) channels. Eur J Pharmacol. 2008;587:204-8 pubmed publisher
    ..Our data demonstrate for the first time direct evidence of decreased aortic Kir6.1/SUR2B subunit expression in hypertension, but preserved functional responses to K(ATP) channel openers...
  55. Ploug K, Sørensen M, Strøbech L, Klaerke D, Hay Schmidt A, Sheykhzade M, et al. K ATP channels in pig and human intracranial arteries. Eur J Pharmacol. 2008;601:43-9 pubmed publisher
    ..Specific blocking of Kir6.1 or SUR2B K(ATP) channel subunits in large cerebral and meningeal arteries may be a future anti-migraine strategy...
  56. Winkler M, Lutz R, Russ U, Quast U, Bryan J. Analysis of two KCNJ11 neonatal diabetes mutations, V59G and V59A, and the analogous KCNJ8 I60G substitution: differences between the channel subtypes formed with SUR1. J Biol Chem. 2009;284:6752-62 pubmed publisher
    ..The results suggest the interfacial helix dynamically links inhibitory inputs from the Kir N terminus to the gate and that sulfonylureas stabilize an inhibitory configuration...
  57. Davies L, Purves G, Barrett Jolley R, Dart C. Interaction with caveolin-1 modulates vascular ATP-sensitive potassium (KATP) channel activity. J Physiol. 2010;588:3255-66 pubmed publisher
  58. Bardou O, Privé A, Migneault F, Roy Camille K, Dagenais A, Berthiaume Y, et al. K+ channels regulate ENaC expression via changes in promoter activity and control fluid clearance in alveolar epithelial cells. Biochim Biophys Acta. 2012;1818:1682-90 pubmed
    ..In summary, our results disclose that K+ channels regulate alpha-ENaC expression by controlling its promoter activity and thus affect the alveolar function of fluid clearance. ..
  59. Giblin J, Cui Y, Clapp L, Tinker A. Assembly limits the pharmacological complexity of ATP-sensitive potassium channels. J Biol Chem. 2002;277:13717-23 pubmed
    ..This incompatibility limits the pharmacological complexity of K(ATP) channels that may be observed in native tissues...
  60. Bondjers C, He L, Takemoto M, Norlin J, Asker N, Hellstrom M, et al. Microarray analysis of blood microvessels from PDGF-B and PDGF-Rbeta mutant mice identifies novel markers for brain pericytes. FASEB J. 2006;20:1703-5 pubmed
    ..Of candidates for novel pericyte markers, we selected ATP-sensitive potassium-channel Kir6.1 (also known as Kcnj8) and sulfonylurea receptor 2, (SUR2, also known as Abcc9), both part of the same channel complex, as well as delta ..
  61. Jiao J, Garg V, Yang B, Elton T, Hu K. Protein kinase C-epsilon induces caveolin-dependent internalization of vascular adenosine 5'-triphosphate-sensitive K+ channels. Hypertension. 2008;52:499-506 pubmed publisher
    ..This finding provides a novel mechanistic insight into how K(ATP) channels are regulated in vascular smooth muscle cells...
  62. Wu X, Liu W, Liu Y, Huang Z, Zhang Y, Song X. Reopening of ATP-sensitive potassium channels reduces neuropathic pain and regulates astroglial gap junctions in the rat spinal cord. Pain. 2011;152:2605-15 pubmed publisher
    ..This study may provide a new strategy for treating neuropathic pain using K(ATP) channel openers in the clinic...
  63. Suzuki M, Kotake K, Fujikura K, Inagaki N, Suzuki T, Gonoi T, et al. Kir6.1: a possible subunit of ATP-sensitive K+ channels in mitochondria. Biochem Biophys Res Commun. 1997;241:693-7 pubmed
    ..1. These results suggest that Kir6.1 might be a subunit of the ATP-sensitive K+ channel in the mitochondrion, as well as in the plasma membrane. ..
  64. Nakaya H, Miki T, Seino S, Yamada K, Inagaki N, Suzuki M, et al. [Molecular and functional diversity of ATP-sensitive K+ channels: the pathophysiological roles and potential drug targets]. Nihon Yakurigaku Zasshi. 2003;122:243-50 pubmed
    ..Further clarification of physiological as well as pathophysiological roles of K(ATP) channels may lead to a new therapeutic strategy to improve the quality of life...
  65. Gabrielsson B, Karlsson A, Lönn M, Olofsson L, Johansson J, Torgerson J, et al. Molecular characterization of a local sulfonylurea system in human adipose tissue. Mol Cell Biochem. 2004;258:65-71 pubmed
    ..1. The expression of SUR2B was higher in subcutaneous compared with omental adipose tissue and was not affected by weight loss...
  66. Xu C, You X, Gao L, Zhang L, Hu R, Hui N, et al. Expression of ATP-sensitive potassium channels in human pregnant myometrium. Reprod Biol Endocrinol. 2011;9:35 pubmed publisher
    ..The objectives of this study were to investigate the protein expression of KATP channel in human myometrium and determine the levels of KATP channel in lower and upper segmental myometrium before and after onset of labour...
  67. Seara F, Barbosa R, de Oliveira D, Gran da Silva D, Carvalho A, Freitas Ferreira A, et al. Administration of anabolic steroid during adolescence induces long-term cardiac hypertrophy and increases susceptibility to ischemia/reperfusion injury in adult Wistar rats. J Steroid Biochem Mol Biol. 2017;171:34-42 pubmed publisher
  68. Sharma V, Nair S, Jaitley P, Nakade U, Sharma A, Choudhury S, et al. ATP-sensitive and maxi potassium channels regulate BRL 37344-induced tocolysis in buffaloes-an in vitro study. Theriogenology. 2017;107:194-202 pubmed publisher
  69. Cui Y, Giblin J, Clapp L, Tinker A. A mechanism for ATP-sensitive potassium channel diversity: Functional coassembly of two pore-forming subunits. Proc Natl Acad Sci U S A. 2001;98:729-34 pubmed
    ..2 or Kir 6.1 expressed with SUR2B. In conclusion, Kir 6.1 and Kir 6.2 readily coassemble to produce functional channels, and such phenomena may contribute to the diversity of nucleotide-regulated potassium currents seen in native tissues...
  70. Nagashima K, Takahashi A, Ikeda H, Hamasaki A, Kuwamura N, Yamada Y, et al. Sulfonylurea and non-sulfonylurea hypoglycemic agents: pharmachological properties and tissue selectivity. Diabetes Res Clin Pract. 2004;66 Suppl 1:S75-8 pubmed
    ..We also suggest possible risk in the use of certain hypoglycemic agents in patients with ischemic heart disease...
  71. Cuong D, Kim N, Joo H, Youm J, Chung J, Lee Y, et al. Subunit composition of ATP-sensitive potassium channels in mitochondria of rat hearts. Mitochondrion. 2005;5:121-33 pubmed
    ..By contrast, SUR1 was not present in mitochondria. These results suggest that mitoKATP channels in rat hearts might comprise a combination of Kir6.1, Kir6.2, and SUR2 subunits...
  72. Croker B, Crozat K, Berger M, Xia Y, Sovath S, Schaffer L, et al. ATP-sensitive potassium channels mediate survival during infection in mammals and insects. Nat Genet. 2007;39:1453-60 pubmed
    ..The phenotype is due to a null allele of Kcnj8, encoding Kir6...
  73. Cooper P, Reutter H, Woelfle J, Engels H, Grange D, van Haaften G, et al. Cantú syndrome resulting from activating mutation in the KCNJ8 gene. Hum Mutat. 2014;35:809-13 pubmed publisher
    ..1 and Kir6.2, encoded by KCNJ8 and KCNJ11, respectively) and regulatory sulfonylurea receptor (SUR1 and SUR2, encoded by ABCC8 and ABCC9, ..
  74. Li S, Wu Y, Jin X, Jiang C. The SUR2B subunit of rat vascular KATP channel is targeted by miR-9a-3p induced by prolonged exposure to methylglyoxal. Am J Physiol Cell Physiol. 2015;308:C139-45 pubmed publisher
    ..These results suggest that MGO exposure raises the expression of miR-9a-3p, which subsequently downregulates the SUR2B mRNA, compromising K(ATP) channel function in vascular smooth muscle...
  75. Nie L, Zhao Y, Luo H, Hu X, Zhang L, Liang H. MiR-20 regulates myocardiac ischemia by targeting KATP subunit Kir6.1. J Huazhong Univ Sci Technolog Med Sci. 2017;37:486-490 pubmed publisher
    ..Luciferase reporter gene assay was performed to confirm the targeting effect of miR-20 on KCNJ8. The results showed that miR-20 was remarkably down-regulated, while the KATP subunit Kir6...
  76. Horie M, Ishida Takahashi A, Ai T, Nishimoto T, Tsuura Y, Ishida H, et al. Insulin secretion and its modulation by antiarrhythmic and sulfonylurea drugs. Cardiovasc Res. 1997;34:69-72 pubmed
    ..1 (a putative KATP channel clone)-transfected NIH3T3 cells. Therefore they appear to interact directly with the pore-forming subunit, thereby inhibiting KATP channel currents and exerting an insulinotrophic effect...
  77. Insuk S, Chae M, Choi J, Yang D, Sim J, Lee S. Molecular basis and characteristics of KATP channel in human corporal smooth muscle cells. Int J Impot Res. 2003;15:258-66 pubmed
    ..These findings, taken together with the electrophysiological results, suggest that K(ATP) channel in corporal smooth muscle cells is composed of heteromultimers of Kir6.1 and Kir6.2 with the ratio of 3 : 1 or 4 : 0 and SUR2B...
  78. Leroy C, Dagenais A, Berthiaume Y, Brochiero E. Molecular identity and function in transepithelial transport of K(ATP) channels in alveolar epithelial cells. Am J Physiol Lung Cell Mol Physiol. 2004;286:L1027-37 pubmed
    ..These results suggest the presence, in AEC, of a K(ATP) channel, formed from Kir6.1 and SUR2B subunits, which plays a physiological role, with KvLQT1 and K(Ca) channels, in Na(+) and Cl(-) transepithelial transport...
  79. Xue H, Zhang Y, Liu G, Wang H. A new ATP-sensitive potassium channel opener protects the kidney from hypertensive damage in spontaneously hypertensive rats. J Pharmacol Exp Ther. 2005;315:501-9 pubmed
  80. Jansen Olesen I, Mortensen C, El Bariaki N, Ploug K. Characterization of K(ATP)-channels in rat basilar and middle cerebral arteries: studies of vasomotor responses and mRNA expression. Eur J Pharmacol. 2005;523:109-18 pubmed
    ..1 or Kir6.2. In basilar arteries, but not in middle cerebral arteries, endothelial K(ATP) channels may be involved...
  81. Yang Y, Li S, Konduru A, Zhang S, Trower T, Shi W, et al. Prolonged exposure to methylglyoxal causes disruption of vascular KATP channel by mRNA instability. Am J Physiol Cell Physiol. 2012;303:C1045-54 pubmed publisher
    ..These results therefore suggest that acting on the 3'-UTR of Kir6.1 and the coding region of SUR2B, MGO causes instability of Kir6.1 and SUR2B mRNAs, disruption of vascular K(ATP) channels, and impairment of arterial function...
  82. Khan F, Choong W, Du Q, Jovanovic A. Real-time RT-PCR threshold cycles value for Kir6.1 from the blood correlates with parameters of vascular function: a potential for the vascular function biomarker?. Biomarkers. 2013;18:221-9 pubmed publisher
    ..Gender had no influence on relationships between blood Kir6.1 Ct and vascular function. We conclude that blood Kir6.1 mRNA levels could be potentially used as a biomarker of the vascular function...
  83. Watanabe Y, Matsumoto A, Miki T, Seino S, Anzai N, Nakaya H. Electrophysiological analyses of transgenic mice overexpressing KCNJ8 with S422L mutation in cardiomyocytes. J Pharmacol Sci. 2017;135:37-43 pubmed publisher
    Genetic analysis of KCNJ8 has pointed a mutation (S422L) as a susceptible link to J wave syndrome (JWS)...
  84. Konstas A, Dabrowski M, Korbmacher C, Tucker S. Intrinsic sensitivity of Kir1.1 (ROMK) to glibenclamide in the absence of SUR2B. Implications for the identity of the renal ATP-regulated secretory K+ channel. J Biol Chem. 2002;277:21346-51 pubmed
    ..1b and is not required to confer glibenclamide sensitivity to Kir1.1b. This has important implications for the presumed structure of the renal ATP-regulated secretory K+ channel...
  85. Seino S, Miki T. Physiological and pathophysiological roles of ATP-sensitive K+ channels. Prog Biophys Mol Biol. 2003;81:133-76 pubmed
    ..In this review, we focus on the physiological and pathophysiological roles of K(ATP) channels learned from genetic manipulation of mice and naturally occurring mutations in humans...
  86. Singh H, Hudman D, Lawrence C, Rainbow R, Lodwick D, Norman R. Distribution of Kir6.0 and SUR2 ATP-sensitive potassium channel subunits in isolated ventricular myocytes. J Mol Cell Cardiol. 2003;35:445-59 pubmed
    ..Combinations of these subunits would not explain the reported pharmacology of the mitochondrial K(ATP) channel (Mol Pharmacol 59 (2001) 225) suggesting the possibility of further unidentified components of this channel...
  87. Tester D, Tan B, Medeiros Domingo A, Song C, Makielski J, Ackerman M. Loss-of-function mutations in the KCNJ8-encoded Kir6.1 K(ATP) channel and sudden infant death syndrome. Circ Cardiovasc Genet. 2011;4:510-5 pubmed publisher
    Approximately 10% of sudden infant death syndrome (SIDS) may stem from cardiac channelopathies. The KCNJ8-encoded Kir6...
  88. Sala Rabanal M, Wang S, Nichols C. On potential interactions between non-selective cation channel TRPM4 and sulfonylurea receptor SUR1. J Biol Chem. 2012;287:8746-56 pubmed publisher
    ..2 and SUR1, whereas there was no detectable FRET efficiency between TRPM4 and SUR1. Our data suggest that functional or structural association of TRPM4 and SUR1 is unlikely...
  89. Zhu J, Li Z, Wang B, Tong X, Peng Q. [Effect of Qibai Pingfei capsule medicated serum on protein expressions of KATP channel in pulmonary arterial smooth muscle cells via nitric oxide]. Zhongguo Zhong Yao Za Zhi. 2017;42:1376-1381 pubmed publisher
    ..The regulatory mechanism was probably associated with up-regulating KATP channel protein expression via NO relative pathway, involving pulmonary vasodilation, and thus relieving the occurence and development of COPD...
  90. Dorschner H, Brekardin E, Uhde I, Schwanstecher C, Schwanstecher M. Stoichiometry of sulfonylurea-induced ATP-sensitive potassium channel closure. Mol Pharmacol. 1999;55:1060-6 pubmed
    ..93-1.06). The data establish that the C terminus of SURs does not affect sulfonylurea affinity and sensitivity. We conclude that occupation of one of the four SUR sites per channel complex is sufficient to induce KATP channel closure...
  91. Vanoye C, MacGregor G, Dong K, Tang L, Buschmann A, Hall A, et al. The carboxyl termini of K(ATP) channels bind nucleotides. J Biol Chem. 2002;277:23260-70 pubmed
    ..Thus, the COOH termini of K(ATP) tetrameric channels contain the nucleotide-binding pockets of these metabolically regulated channels with four potential nucleotide-binding sites/channel tetramer. ..
  92. Miki T, Suzuki M, Shibasaki T, Uemura H, Sato T, Yamaguchi K, et al. Mouse model of Prinzmetal angina by disruption of the inward rectifier Kir6.1. Nat Med. 2002;8:466-72 pubmed
    ..We report here that mice lacking the gene encoding Kir6.1 (known as Kcnj8) have a high rate of sudden death associated with spontaneous ST elevation followed by atrioventricular block as ..
  93. Nakamura K, Hirano J, Itazawa S, Kubokawa M. Protein kinase G activates inwardly rectifying K(+) channel in cultured human proximal tubule cells. Am J Physiol Renal Physiol. 2002;283:F784-91 pubmed
    ..In conclusion, cGMP/PKG-dependent processes participate in activating the ATP-regulated K(+) channel and producing the stimulatory effect of ANP on channel activity. ..
  94. Tang Y, Long C, Wang R, Cui W, Wang H. Activation of SUR2B/Kir6.1 subtype of adenosine triphosphate-sensitive potassium channel improves pressure overload-induced cardiac remodeling via protecting endothelial function. J Cardiovasc Pharmacol. 2010;56:345-53 pubmed publisher
    ..These results indicate that natakalim reduces heart failure caused by pressure overloading by activating the SUR2B/Kir6.1 KATP channel subtype and protecting against endothelial dysfunction...
  95. Aziz Q, Thomas A, Khambra T, Tinker A. Regulation of the ATP-sensitive potassium channel subunit, Kir6.2, by a Ca2+-dependent protein kinase C. J Biol Chem. 2012;287:6196-207 pubmed publisher
    ..2 (Ser-372) whose phosphorylation leads to down-regulation of the channel complex. This inhibitory effect is distinct from activation which is seen with low levels of channel activity...
  96. Du Q, Jovanovic S, Tulic L, Sljivančanin D, Jack D, Zizić V, et al. KATP channels are up-regulated with increasing age in human myometrium. Mech Ageing Dev. 2013;134:98-102 pubmed publisher
    ..Thus, this study suggests that KATP channels are up-regulated with increasing age in human myometrium. This may help explain, at least partially, increased rate of birth complications in women aged over 35 years. ..
  97. Tivesten A, Barlind A, Caidahl K, Klintland N, Cittadini A, Ohlsson C, et al. Growth hormone-induced blood pressure decrease is associated with increased mRNA levels of the vascular smooth muscle KATP channel. J Endocrinol. 2004;183:195-202 pubmed
    ..Increased expression of the ATP-sensitive potassium channel, recently shown to be crucial in the regulation of vascular tone, constitutes a possible mechanism by which GH governs vascular tone...
  98. Kawano T, Oshita S, Takahashi A, Tsutsumi Y, Tanaka K, Tomiyama Y, et al. Molecular mechanisms underlying ketamine-mediated inhibition of sarcolemmal adenosine triphosphate-sensitive potassium channels. Anesthesiology. 2005;102:93-101 pubmed
    ..1 or Kir6.2) and sulfonylurea receptors (SUR1, SUR2A, or SUR2B)...