KCNJ5

Summary

Gene Symbol: KCNJ5
Description: potassium voltage-gated channel subfamily J member 5
Alias: CIR, GIRK4, KATP1, KIR3.4, LQT13, G protein-activated inward rectifier potassium channel 4, IRK-4, cardiac ATP-sensitive potassium channel, heart KATP channel, inward rectifier K+ channel KIR3.4, potassium channel, inwardly rectifying subfamily J, member 5, potassium inwardly-rectifying channel, subfamily J, member 5
Species: human
Products:     KCNJ5

Top Publications

  1. Choi M, Scholl U, Yue P, Björklund P, Zhao B, Nelson Williams C, et al. K+ channel mutations in adrenal aldosterone-producing adenomas and hereditary hypertension. Science. 2011;331:768-72 pubmed publisher
    ..We identify two recurrent somatic mutations in and near the selectivity filter of the potassium (K(+)) channel KCNJ5 that are present in 8 of 22 human APAs studied...
  2. Taguchi R, Yamada M, Nakajima Y, Satoh T, Hashimoto K, Shibusawa N, et al. Expression and mutations of KCNJ5 mRNA in Japanese patients with aldosterone-producing adenomas. J Clin Endocrinol Metab. 2012;97:1311-9 pubmed publisher
    Mutations of the KCNJ5 gene have recently been identified in patients with aldosterone-producing adenomas (APA). Our objective was to investigate the expression and mutations of the KCNJ5 gene in Japanese patients with APA...
  3. Zhang C, Yuan G, Cheng Z, Xu M, Hou L, Wei F. The single nucleotide polymorphisms of Kir3.4 gene and their correlation with lone paroxysmal atrial fibrillation in Chinese Han population. Heart Lung Circ. 2009;18:257-61 pubmed publisher
    ..364 (95% CI 5.710-31.278) and 37.135 (95% CI 9.050-152.381) when comparing patients with T-G genotype. Our findings suggest that C171T and G810T SNPs in Kir3.4 gene might be risk factors for lone paroxysmal AF in Chinese population. ..
  4. Shankar H, Murugappan S, Kim S, Jin J, Ding Z, Wickman K, et al. Role of G protein-gated inwardly rectifying potassium channels in P2Y12 receptor-mediated platelet functional responses. Blood. 2004;104:1335-43 pubmed
    ..Western blot analysis revealed that platelets express GIRK1, GIRK2, and GIRK4. In aspirin-treated and washed human platelets, 2 structurally distinct GIRK inhibitors, SCH23390 (R(+)-7-chloro-8-..
  5. Jabbari J, Olesen M, Holst A, Nielsen J, Haunso S, Svendsen J. Common polymorphisms in KCNJ5 [corrected] are associated with early-onset lone atrial fibrillation in Caucasians. Cardiology. 2011;118:116-20 pubmed publisher
    ..aim of this study was to screen lone atrial fibrillation (AF) patients for mutations in the genes KCNJ2, KCNJ3 and KCNJ5, all encoding potassium channels...
  6. Akerström T, Crona J, Delgado Verdugo A, Starker L, Cupisti K, Willenberg H, et al. Comprehensive re-sequencing of adrenal aldosterone producing lesions reveal three somatic mutations near the KCNJ5 potassium channel selectivity filter. PLoS ONE. 2012;7:e41926 pubmed publisher
    ..Recently, either of two recurrent somatic missense mutations (G151R or L168R) was found in the potassium channel KCNJ5 gene in aldosterone producing adenomas...
  7. Azizan E, Murthy M, Stowasser M, Gordon R, Kowalski B, Xu S, et al. Somatic mutations affecting the selectivity filter of KCNJ5 are frequent in 2 large unselected collections of adrenal aldosteronomas. Hypertension. 2012;59:587-91 pubmed publisher
    ..rare familial forms of primary hyperaldosteronism, but it has been reported recently that somatic mutations of the KCNJ5 gene, which encodes a potassium channel, are present in some sporadic nonsyndromic APAs...
  8. Scholl U, Nelson Williams C, Yue P, GREKIN R, Wyatt R, Dillon M, et al. Hypertension with or without adrenal hyperplasia due to different inherited mutations in the potassium channel KCNJ5. Proc Natl Acad Sci U S A. 2012;109:2533-8 pubmed publisher
    We recently implicated two recurrent somatic mutations in an adrenal potassium channel, KCNJ5, as a cause of aldosterone-producing adrenal adenomas (APAs) and one inherited KCNJ5 mutation in a Mendelian form of early severe hypertension ..
  9. Mulatero P, Tauber P, Zennaro M, Monticone S, Lang K, Beuschlein F, et al. KCNJ5 mutations in European families with nonglucocorticoid remediable familial hyperaldosteronism. Hypertension. 2012;59:235-40 pubmed publisher
    ..Three forms of familial hyperaldosteronism (FH) have been described, named FH-I to -III. Recently, a mutation of KCNJ5 has been shown to be associated with FH-III, whereas the cause of FH-II is still unknown...

More Information

Publications125 found, 100 shown here

  1. Murthy M, Azizan E, Brown M, O Shaughnessy K. Characterization of a novel somatic KCNJ5 mutation delI157 in an aldosterone-producing adenoma. J Hypertens. 2012;30:1827-33 pubmed publisher
    ..adenomas (APAs) are an increasingly recognized cause of primary aldosteronism, and somatic mutations within the KCNJ5 gene encoding an inwardly rectifying K(+) channel (also called GIRK4 or Kir3...
  2. Ma D, Zerangue N, Raab Graham K, Fried S, Jan Y, Jan L. Diverse trafficking patterns due to multiple traffic motifs in G protein-activated inwardly rectifying potassium channels from brain and heart. Neuron. 2002;33:715-29 pubmed
    ..3 subunit potently inhibits plasma membrane expression by diverting the heterotetrameric channels to lysosomes. Such rich trafficking behaviors provide a mechanism for dynamic regulation of GIRK channel density in the plasma membrane. ..
  3. Li N, Zhang D, Zhang J, Guo Y, Yan Z, Wang H, et al. Influence of age on the association of GIRK4 with metabolic syndrome. Ann Clin Biochem. 2012;49:369-76 pubmed publisher
    G protein-coupled inward rectifier K+ channel 4 (GIRK4) gene expressions have been implicated in the development of obesity, a key feature of metabolic syndrome (MetS)...
  4. Boulkroun S, Beuschlein F, Rossi G, Golib Dzib J, Fischer E, Amar L, et al. Prevalence, clinical, and molecular correlates of KCNJ5 mutations in primary aldosteronism. Hypertension. 2012;59:592-8 pubmed publisher
    Primary aldosteronism is the most common form of secondary hypertension. Mutations in the KCNJ5 gene have been described recently in aldosterone-producing adenomas (APAs)...
  5. Felizola S, Katsu K, Ise K, Nakamura Y, Arai Y, Satoh F, et al. Pre-B Lymphocyte Protein 3 (VPREB3) Expression in the Adrenal Cortex: Precedent for non-Immunological Roles in Normal and Neoplastic Human Tissues. Endocr Pathol. 2015;26:119-28 pubmed publisher
    ..026; R = 0.30), KCNJ5 mutations (P = 0.0061; mutated 34:19 wild type), CYP11B2 (P < 0...
  6. Thirunavukkarasu M, Selvaraju V, Tapias L, Sanchez J, Palesty J, Maulik N. Protective effects of Phyllanthus emblica against myocardial ischemia-reperfusion injury: the role of PI3-kinase/glycogen synthase kinase 3β/β-catenin pathway. J Physiol Biochem. 2015;71:623-33 pubmed publisher
    ..Experimental animals were divided into four groups: control sham (CS), P. emblica sham (PS), control I/R (CIR), and P. emblica I/R (PIR). Rats in the P. emblica groups were gavaged with aqueous P...
  7. Kobuke K, Oki K, Gomez Sanchez C, Gomez Sanchez E, Ohno H, Itcho K, et al. Calneuron 1 Increased Ca2+ in the Endoplasmic Reticulum and Aldosterone Production in Aldosterone-Producing Adenoma. Hypertension. 2018;71:125-133 pubmed publisher
    ..The silencing of CALN1 decreased Ca2+ in ER, and abrogated angiotensin II- or KCNJ5 T158A-mediated aldosterone production in HAC15 cells...
  8. Yang T, Zhang H, Liang Q, Shi Y, Mei Y, Barrett P, et al. Small-Conductance Ca2+-Activated Potassium Channels Negatively Regulate Aldosterone Secretion in Human Adrenocortical Cells. Hypertension. 2016;68:785-95 pubmed publisher
    ..Recent clinical studies have highlighted the pathological role of the KCNJ5 potassium channel in primary hyperaldosteronism...
  9. Tong A, Liu G, Wang F, Jiang J, Yan Z, Zhang D, et al. A Novel Phenotype of Familial Hyperaldosteronism Type III: Concurrence of Aldosteronism and Cushing's Syndrome. J Clin Endocrinol Metab. 2016;101:4290-4297 pubmed
    ..He had massive bilateral adrenal hyperplasia and underwent left adrenalectomy. KCNJ5 was sequenced, and secretion of aldosterone and cortisol were observed both in vivo and in vitro...
  10. Ercumen A, Arnold B, Kumpel E, Burt Z, Ray I, Nelson K, et al. Upgrading a piped water supply from intermittent to continuous delivery and association with waterborne illness: a matched cohort study in urban India. PLoS Med. 2015;12:e1001892 pubmed publisher
    ..areas also had 42% fewer households with ≥1 reported case of typhoid fever (cumulative incidence ratio [CIR] = 0.58, 95% CI: 0.41-0.78, p = 0.001) than intermittent supply areas...
  11. Bello Lujan L, Saavedra Santana P, Gutiérrez García L, García Hernández J, Serra Majem L. [SOCIODEMOGRAPHIC AND HEALTH CHARACTERISTICS ASSOCIATED WITH LOW BIRTH WEIGHT IN THE CANARY ISLANDS]. Nutr Hosp. 2015;32:1541-7 pubmed publisher
    ..The highest OR correspond to fetal intrauterine growth retardation (CIR) (OR = 6.3; 95% CI = 5.3, 7.4), hypertension/eclampsia (OR = 3.2; 95% CI = 2.1; 5...
  12. Auguste P, Tsertsvadze A, Pink J, Court R, McCarthy N, Sutcliffe P, et al. Comparing interferon-gamma release assays with tuberculin skin test for identifying latent tuberculosis infection that progresses to active tuberculosis: systematic review and meta-analysis. BMC Infect Dis. 2017;17:200 pubmed publisher
    ..Summary effect measures: the ratio of CIRs (R-CIR) with 95% CIs. R-CIRs, were pooled using a random-effects model...
  13. Marx S. Hyperplasia in glands with hormone excess. Endocr Relat Cancer. 2016;23:R1-14 pubmed publisher
    ..systemic vascular permeabilities during pregnancy; and familial hyperaldosteronism type IIIA, from mutated KCNJ5, presents in young children with hypertension and hypokalemia...
  14. Pons Fernández N, Moreno F, Morata J, Moriano A, León S, De Mingo C, et al. Familial hyperaldosteronism type III a novel case and review of literature. Rev Endocr Metab Disord. 2018;: pubmed publisher
    ..FH III is caused by germline mutations in KCNJ5, encoding the potassium channel Kir3.4...
  15. Zennaro M, Jeunemaitre X. SFE/SFHTA/AFCE consensus on primary aldosteronism, part 5: Genetic diagnosis of primary aldosteronism. Ann Endocrinol (Paris). 2016;77:214-9 pubmed publisher
    ..Mild forms, resembling FH-II, have been described. FH-III is due to gain-of-function mutations in the KCNJ5 gene...
  16. Zennaro M, Boulkroun S, Fernandes Rosa F. An update on novel mechanisms of primary aldosteronism. J Endocrinol. 2015;224:R63-77 pubmed publisher
    ..Recurrent somatic mutations in genes coding for ion channels (KCNJ5 and CACNA1D) and ATPases (ATP1A1 and ATP2B3) regulating intracellular ionic homeostasis and cell membrane ..
  17. Yoshii Y, Oki K, Gomez Sanchez C, Ohno H, Itcho K, Kobuke K, et al. Hypomethylation of CYP11B2 in Aldosterone-Producing Adenoma. Hypertension. 2016;68:1432-1437 pubmed
    ..was conducted using nonfunctioning adrenocortical adenoma (n=12) and APA (n=35) samples, including some with a KCNJ5 mutation (n=21), an ATP1A1 mutation (n=5), and without the known mutations (n=9)...
  18. Zhu C, Lü G, Qi T, He Q, Chen Y, Wen W, et al. [Long-term prognosis and quality of life of survivors with hepatitis B virus-related acute-on-chronic liver failure]. Nan Fang Yi Ke Da Xue Xue Bao. 2018;38:736-741 pubmed
    ..patients were divided into chronic hepatitis B-related ACLF (CHB-ACLF) group (n=130) and liver cirrhosis ACLF (CIR-ACLF) group (n=93). The 12-, 24- and 50-month survival rates in CHB-ACLF group were 97%, 95.7% and 93...
  19. Fang R, Zhao N, Zeng K, Wen Q, Xiao P, Luo X, et al. MicroRNA-544 inhibits inflammatory response and cell apoptosis after cerebral ischemia reperfusion by targeting IRAK4. Eur Rev Med Pharmacol Sci. 2018;22:5605-5613 pubmed publisher
    ..The correlation between the expression of miR-544 and the degree of cerebral ischemia reperfusion (CIR) injury has not been well recognized in recent years...
  20. Song L, Li D, Wang J, Meng C, Cui X. Effects of p38 mitogen-activated protein kinase on lung ischemia-reperfusion injury in diabetic rats. J Surg Res. 2017;216:9-17 pubmed publisher
    ..randomly divided into the following five groups (n = 8 each): a control + sham group, a control + IR group (CIR), a DM + sham group, a DM + IR group (DIR), and a DM + IR + SB203580 group...
  21. Aristizabal Prada E, Castellano I, Sušnik E, Yang Y, Meyer L, Tetti M, et al. Comparative Genomics and Transcriptome Profiling in Primary Aldosteronism. Int J Mol Sci. 2018;19: pubmed publisher
    ..adenomas frequently carry a causative somatic mutation in either of a number of genes with the KCNJ5 gene, encoding an inwardly rectifying potassium channel, a recurrent target harboring mutations at a ..
  22. Felizola S, Maekawa T, Nakamura Y, Satoh F, Ono Y, Kikuchi K, et al. Voltage-gated calcium channels in the human adrenal and primary aldosteronism. J Steroid Biochem Mol Biol. 2014;144 Pt B:410-6 pubmed publisher
    ..0031), CYP11B2 expression levels (P<0.0001) and the presence of KCNJ5 mutations (P=0.0019) in APA...
  23. Monticone S, Buffolo F, Tetti M, Veglio F, Pasini B, Mulatero P. GENETICS IN ENDOCRINOLOGY: The expanding genetic horizon of primary aldosteronism. Eur J Endocrinol. 2018;178:R101-R111 pubmed publisher
    ..Somatic mutations in four genes (KCNJ5, ATP1A1, ATP2B3 and CACNA1D), differently implicated in intracellular ion homeostasis, have been ..
  24. Ahn Y, Choi Y, Yoon J, Lee Y, Cho K, Kang D, et al. Oleanolic acid modulates the renin-angiotensin system and cardiac natriuretic hormone concomitantly with volume and pressure balance in rats. Eur J Pharmacol. 2017;809:231-241 pubmed publisher
    ..of renin, angiotensin II receptors, ANP, natriuretic peptide receptor-C, M2 muscarinic receptor and GIRK4 were determined in the kidney, heart and aorta. Oleanolic acid was administered orally for 1 or 3 weeks...
  25. Itcho K, Oki K, Kobuke K, Yoshii Y, Ohno H, Yoneda M, et al. Aberrant G protein-receptor expression is associated with DNA methylation in aldosterone-producing adenoma. Mol Cell Endocrinol. 2018;461:100-104 pubmed publisher
    ..Methylation levels were not associated with KCNJ5 or ATP1A1 mutations in human adrenal samples...
  26. Law A, Salas M, Lam W, Michelis F, Thyagu S, Kim D, et al. Reduced-Intensity Conditioning and Dual T Lymphocyte Suppression with Antithymocyte Globulin and Post-Transplant Cyclophosphamide as Graft-versus-Host Disease Prophylaxis in Haploidentical Hematopoietic Stem Cell Transplants for Hematological Maligna. Biol Blood Marrow Transplant. 2018;24:2259-2264 pubmed publisher
    ..Six-month and 1-year overall survival (OS), cumulative incidence of relapse (CIR), and nonrelapse mortality (NRM) were 73.9%, 10.2%, and 19.4%, respectively, and 48.1%, 16% and 38.2%, respectively...
  27. Aljumah A, Kuriry H, Faisal N, Alghamdi H. Clinicopathologic characteristics andoutcomes of hepatocellular carcinoma associated with chronic hepatitis B versus hepatitis C infection. Ann Saudi Med. 2018;38:358-365 pubmed publisher
    ..048). The prevalence of comorbidities and pre-existing cir.rhosis was similar in both groups. Seven patients (6...
  28. Lenzini L, Rossi G. The molecular basis of primary aldosteronism: from chimeric gene to channelopathy. Curr Opin Pharmacol. 2015;21:35-42 pubmed publisher
    ..Only a minority of the PA cases are familial and due to known (CYP11B2/CYP11B1 chimeric gene or mutations in the KCNJ5 gene) or unknown causes...
  29. Ferdous Z, Qureshi M, Jayaprakash P, Parekh K, John A, Oz M, et al. Different Profile of mRNA Expression in Sinoatrial Node from Streptozotocin-Induced Diabetic Rat. PLoS ONE. 2016;11:e0153934 pubmed publisher
    ..Trpc6 (4-fold); intracellular Ca2+-transport, Ryr3; calcium channel Cacna1g, Cacna1h, Cacnb3; potassium channels, Kcnj5, Kcnk3 and natriuretic peptides, Nppa (5-fold) and Nppb (7-fold)...
  30. Åkerström T, Maharjan R, Sven Willenberg H, Cupisti K, Ip J, Moser A, et al. Activating mutations in CTNNB1 in aldosterone producing adenomas. Sci Rep. 2016;6:19546 pubmed publisher
    ..Somatic CTNNB1 mutations were detected in 5.1% of the tumors, occurring mutually exclusive from mutations in KCNJ5, ATP1A1, ATP2B3 and CACNA1D...
  31. Sendlhofer G, Leitgeb K, Kober B, Brunner G, Kamolz L. [The evolution of the Critical Incident Reporting System in an Austrian university hospital]. Z Evid Fortbild Qual Gesundhwes. 2016;114:48-57 pubmed publisher
    ..However, in Europe CIR systems are differently used with respect to whether its use is voluntary or mandatory...
  32. Jastaniah W, Alsultan A, Al Daama S, Ballourah W, Bayoumy M, Al Anzi F, et al. Treatment results in children with myeloid leukemia of Down syndrome in Saudi Arabia: A multicenter SAPHOS leukemia group study. Leuk Res. 2017;58:48-54 pubmed publisher
    ..Complete remission, cumulative incidences of relapse (CIR), toxic-death, and 5-year event-free survival (EFS) rates were 96.8%, 19.4%, 13.1%, and 67.7±8.4%; respectively...
  33. Huang X, Lee S, Lu H, Sanders K, Koh S. Molecular and functional characterization of inwardly rectifying K+ currents in murine proximal colon. J Physiol. 2018;596:379-391 pubmed publisher
    ..Transcripts of Kcnj2 (Kir2.1), Kcnj4 (Kir2.3), Kcnj14 (Kir2.4), Kcnj5 (Kir3.4), Kcnj8 (Kir 6.1) and Kcnj11 (Kir6.2) were found in colonic ICC...
  34. Johnson W, Heldreth B, Bergfeld W, Belsito D, Hill R, Klaassen C, et al. Safety Assessment of Dimethiconol and Its Esters and Reaction Products as Used in Cosmetics. Int J Toxicol. 2017;36:31S-50S pubmed publisher
    ..The Cosmetic Ingredient Review (CIR) Expert Panel reviewed relevant data and concluded that these ingredients are safe in the present practices of use ..
  35. Matsubayashi Y, Yoshida A, Suganami H, Ishiguro H, Yamamoto M, Fujihara K, et al. Role of fatty liver in the association between obesity and reduced hepatic insulin clearance. Diabetes Metab. 2018;44:135-142 pubmed publisher
    ..HIC was calculated from the ratio of fasting c-peptide to fasting insulin levels (HICCIR)...
  36. Doupnik C, Davidson N, Lester H. The inward rectifier potassium channel family. Curr Opin Neurobiol. 1995;5:268-77 pubmed
  37. Corey S, Clapham D. Identification of native atrial G-protein-regulated inwardly rectifying K+ (GIRK4) channel homomultimers. J Biol Chem. 1998;273:27499-504 pubmed
    ..1) and either GIRK2 (Kir3.2), GIRK3 (Kir3.3), or GIRK4 (Kir3.4) subunits...
  38. Adachi M, Muroya K, Asakura Y, Sugiyama K, Homma K, Hasegawa T. Discordant genotype-phenotype correlation in familial hyperaldosteronism type III with KCNJ5 gene mutation: a patient report and review of the literature. Horm Res Paediatr. 2014;82:138-42 pubmed publisher
    ..hyperaldosteronism type III (FH-III) is a rare autosomal dominant disease for which five missense mutations in KCNJ5 have been identified...
  39. Hong A, Kim J, Song Y, Lee K, Seo S, Seong M, et al. Genetics of Aldosterone-Producing Adenoma in Korean Patients. PLoS ONE. 2016;11:e0147590 pubmed publisher
    Recently, somatic mutations in KCNJ5, ATP1A1, ATP2B3, and CACNA1D genes were found to be associated with the pathogenesis of aldosterone-producing adenoma (APA)...
  40. Edizer D, Adatepe T, Uzun N, Yigit O, Gunduz A, Yıldız M, et al. Electrophysiologic Evaluation of the Facial Nerve and Blink Reflex Pathways in Asymptomatic Cochlear Implant Users. Otolaryngol Head Neck Surg. 2016;155:843-849 pubmed
    ..All recordings were performed when the external part of the implant was in place (CIp) and after its removal (CIr), except occipitalis recordings, which were performed only after removal...
  41. Bao X, Cai W, He X, Chen S, Qiu H, Sun A, et al. [Risk Factors of Leukemia-free Survival in Ph+ ALL Patients with Allogeneic Hematopoietic Stem Cell Transplantation]. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2017;25:1787-1792 pubmed publisher
    ..49 cases turn into negative before transplantation, of which the expected 5-year cumulative incidence of relapse (CIR), non-relapse mortality (NRM) and overall survival (OS) were 26.5%, 29.5% and 41.6%, respectively...
  42. He C, Yan X, Zhang H, Mirshahi T, Jin T, Huang A, et al. Identification of critical residues controlling G protein-gated inwardly rectifying K(+) channel activity through interactions with the beta gamma subunits of G proteins. J Biol Chem. 2002;277:6088-96 pubmed
    ..approaches, we identified minimal N- and C-terminal G beta gamma -binding domains responsible for stimulation of GIRK4 channel activity...
  43. Novak R, Kambou J, Diomandé F, Tarbangdo T, Ouédraogo Traoré R, Sangare L, et al. Serogroup A meningococcal conjugate vaccination in Burkina Faso: analysis of national surveillance data. Lancet Infect Dis. 2012;12:757-64 pubmed publisher
    ..probable meningococcal meningitis across the age group targeted for vaccination (62%, cumulative incidence ratio [CIR] 0·38, 95% CI 0·31-0·45, p<0·0001), and among children aged less than 1 year (54%, 0·46, 0·24-0·86, p=0·..
  44. Kadota K, Buitrago D, Lee M, Villena Vargas J, Sima C, Jones D, et al. Tumoral CD10 expression correlates with high-grade histology and increases risk of recurrence in patients with stage I lung adenocarcinoma. Lung Cancer. 2015;89:329-36 pubmed publisher
    ..with high tumoral CD10 (score>1, n=57) was significantly higher (5-year cumulative incidence of recurrence [CIR], 37%) than in those with low CD10 (score≤1; n=256; 5-year CIR, 16%; P<0...
  45. Bingen B, Askar S, Neshati Z, Feola I, Panfilov A, de Vries A, et al. Constitutively Active Acetylcholine-Dependent Potassium Current Increases Atrial Defibrillation Threshold by Favoring Post-Shock Re-Initiation. Sci Rep. 2015;5:15187 pubmed publisher
    ..Genetic knockdown experiments, using lentiviral vectors encoding a Kcnj5-specific shRNA to modulate IK,ACh-c, yielded similar results...
  46. Williams T, Peitzsch M, Dietz A, Dekkers T, Bidlingmaier M, Riester A, et al. Genotype-Specific Steroid Profiles Associated With Aldosterone-Producing Adenomas. Hypertension. 2016;67:139-45 pubmed publisher
    ..Somatic KCNJ5 mutations are found in APA at a prevalence of around 40% that drive and sustain aldosterone excess...
  47. Kullmann S, Fritsche A, Wagner R, Schwab S, Häring H, Preissl H, et al. Hypothalamic insulin responsiveness is associated with pancreatic insulin secretion in humans. Physiol Behav. 2017;176:134-138 pubmed publisher
    ..Three established insulin secretion indices (insulinogenic index [IGI], corrected insulin response [CIR], and AUCC-peptide0-30/AUCglucose0-30) were then analyzed for correlations with hypothalamic ..
  48. Robitaille M, Ramakrishnan N, Baragli A, Hebert T. Intracellular trafficking and assembly of specific Kir3 channel/G protein complexes. Cell Signal. 2009;21:488-501 pubmed publisher
    ..Taken together, our data show that these "precocious" channel/G protein interactions are specific and may have implications beyond their basic function in signalling events. ..
  49. Kang Y, Hu Y, Li N. Advances in research on G protein-coupled inward rectifier K(+) channel gene. Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2012;34:426-30 pubmed publisher
    G protein-coupled inward rectifier K(+) channel 4(GIRK4) is a G protein-coupled inward rectifier potassium channel family member. Encoded by the KCNJ5, it is widely distributed in the mammalian heart, brain, and other tissues and organs...
  50. Arnesen T, Glomnes N, Strømsøy S, Knappskog S, Heie A, Akslen L, et al. Outcome after surgery for primary hyperaldosteronism may depend on KCNJ5 tumor mutation status: a population-based study from Western Norway. Langenbecks Arch Surg. 2013;398:869-74 pubmed publisher
    ..Some cases of PA were recently found to be caused by mutations in the potassium channel KCNJ5. Our objective was to determine the mutation status of KCNJ5 and seven additional candidate genes for ..
  51. Potter V, Iacobelli S, van Biezen A, Maertens J, Bourhis J, Passweg J, et al. Comparison of Intensive Chemotherapy and Hypomethylating Agents before Allogeneic Stem Cell Transplantation for Advanced Myelodysplastic Syndromes: A Study of the Myelodysplastic Syndrome Subcommittee of the Chronic Malignancies Working Party of the . Biol Blood Marrow Transplant. 2016;22:1615-1620 pubmed publisher
    ..between HMA and CC for overall survival (OS), relapse-free survival (RFS), cumulative incidence of relapse (CIR), and nonrelapse mortality (NRM): OS (42% versus 35%), RFS (29% versus 31%), CIR (45% versus 40%), and NRM (26% ..
  52. Sarkar S, Mukherjee A, Swarnakar S, Das N. Nanocapsulated Ascorbic Acid in Combating Cerebral Ischemia Reperfusion- Induced Oxidative Injury in Rat Brain. Curr Alzheimer Res. 2016;13:1363-1373 pubmed
    ..oxygen species (ROS) generated by induced oxidative stress in the episodes of cerebral ischemia-reperfusion (CIR) plays major role in neurodegeneration...
  53. Kitamoto T, Omura M, Suematsu S, Saito J, Nishikawa T. KCNJ5 mutation as a predictor for resolution of hypertension after surgical treatment of aldosterone-producing adenoma. J Hypertens. 2017;: pubmed publisher
    To investigate the effect of KCNJ5 mutations on the cure of hypertension in patients with aldosterone-producing adenoma (APA) after unilateral adrenalectomy.
  54. Fiume M, Heldreth B, Boyer I, Bergfeld W, Belsito D, Hill R, et al. Safety Assessment of Cross-Linked Alkyl Acrylates as Used in Cosmetics. Int J Toxicol. 2017;36:59S-88S pubmed publisher
    The Cosmetic Ingredient Review (CIR) Expert Panel assessed the safety of cross-linked alkyl acrylates as used in cosmetics...
  55. Hagenfeld D, Borkenhagen B, Schulz T, Schillers H, Schumacher U, Prehm P. Hyaluronan export through plasma membranes depends on concurrent K+ efflux by K(ir) channels. PLoS ONE. 2012;7:e39096 pubmed publisher
    ..siRNA for the K(+) channels K(ir)3.4 and K(ir)6.2 inhibited hyaluronan export. Collectively, these results indicated that hyaluronan export depends on concurrent K(+) efflux...
  56. Rodriguez Morales A, Cardona Ospina J, Villamil Gómez W, Paniz Mondolfi A. How many patients with post-chikungunya chronic inflammatory rheumatism can we expect in the new endemic areas of Latin America?. Rheumatol Int. 2015;35:2091-4 pubmed publisher
    Post-chikungunya chronic inflammatory rheumatism (pCHIK-CIR) is one of the consequences that are impacting new endemic countries, such as those in the Americas. The relative frequency of pCHIK-CIR is highly variable, ranging from 14...
  57. Daniil G, Fernandes Rosa F, Chemin J, Blesneac I, Beltrand J, Polak M, et al. CACNA1H Mutations Are Associated With Different Forms of Primary Aldosteronism. EBioMedicine. 2016;13:225-236 pubmed publisher
    Primary aldosteronism (PA) is the most common form of secondary hypertension. Mutations in KCNJ5, ATP1A1, ATP2B3 and CACNA1D are found in aldosterone producing adenoma (APA) and familial hyperaldosteronism (FH)...
  58. Qin Y, Wang Y, Xu L, Zhang X, Chen H, Han W, et al. The dynamics of RUNX1-RUNX1T1 transcript levels after allogeneic hematopoietic stem cell transplantation predict relapse in patients with t(8;21) acute myeloid leukemia. J Hematol Oncol. 2017;10:44 pubmed publisher
    ..lt;4-log reduction at ≥12 months was significantly related to a higher 3-year cumulative incidence of relapse (CIR) rate in both the entire cohort and the patients with no intervention after HSCT (58.4 vs. 2.2%, 76.5 vs. 2...
  59. Fowler C, Aryal P, Suen K, Slesinger P. Evidence for association of GABA(B) receptors with Kir3 channels and regulators of G protein signalling (RGS4) proteins. J Physiol. 2007;580:51-65 pubmed
    ..2a and RGS4 nor between Kir3.2a and Galphao. These data are discussed in terms of a model in which GABA(B) receptors, G proteins, RGS4 proteins and Kir3 channels are closely associated in a signalling complex. ..
  60. Wang F, Liu J, Hong L, Liang B, Graff C, Yang Y, et al. The phenotype characteristics of type 13 long QT syndrome with mutation in KCNJ5 (Kir3.4-G387R). Heart Rhythm. 2013;10:1500-6 pubmed publisher
    Long QT syndrome type 13 (LQT13) is caused by loss-of-function mutation in the KCNJ5-encoded cardiac G-protein-coupled inward rectifier potassium channel subtype 4 protein...
  61. Faillot S, Assie G. ENDOCRINE TUMOURS: The genomics of adrenocortical tumors. Eur J Endocrinol. 2016;174:R249-65 pubmed publisher
    ..Exome sequencing identified new major drivers in all tumor types, including KCNJ5, ATP1A1, ATP2B3 and CACNA1D mutations in aldosterone-producing adenomas (APA), PRKACA mutations in cortisol-..
  62. Stallmeyer B, Kuß J, Kotthoff S, Zumhagen S, Vowinkel K, Rinné S, et al. A Mutation in the G-Protein Gene GNB2 Causes Familial Sinus Node and Atrioventricular Conduction Dysfunction. Circ Res. 2017;120:e33-e44 pubmed publisher
    ..Our findings describe for the first time a role of a mutant G-protein in the nonsyndromic pacemaker disease because of GIRK channel activation. ..
  63. Salama G, Sullivan C, Holzwanger D, Giambrone A, Min R, Hentel K. Improving Care and Education Through a Radiology Resident-driven Clinical Consultation Service. Acad Radiol. 2017;24:1175-1181 pubmed publisher
    ..A resident-driven clinical imaging rounds (CIR) program initiated at our institution allows radiologists to actively and directly participate in the team-based ..
  64. Yanagiya M, Nitadori J, Nagayama K, Anraku M, Sato M, Nakajima J. Prognostic significance of the preoperative neutrophil-to-lymphocyte ratio for complete resection of thymoma. Surg Today. 2018;48:422-430 pubmed publisher
    ..RFS), disease-specific survival (DSS), disease-related survival (DRS), and the cumulative incidence of recurrence (CIR) differed significantly between the groups...
  65. Schrader T, Tetzlaff L, Löwe K, Schröder C, Beck E. [A structured case analysis from the Critical Incident Reporting System of the German Medical Association and the National Association of Statutory Health Insurance Physicians]. Z Evid Fortbild Qual Gesundhwes. 2018;133:24-29 pubmed publisher
    ..The OPT model allows for the analysis of both single cases and complete data sets of CIR systems and is able to disclose structural problems of clinical management.
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    K(+) outward currents in the outer hair cells (OHCs) of circling mice (homozygous (cir/cir) mice), an animal model for human deafness (DFNB6 type), were investigated using a whole cell patch clamp technique...
  67. Henn M, Janjua M, Kanter E, Makepeace C, Schuessler R, Nichols C, et al. Adenosine Triphosphate-Sensitive Potassium Channel Kir Subunits Implicated in Cardioprotection by Diazoxide. J Am Heart Assoc. 2015;4:e002016 pubmed publisher
    ..1, and Kir3.4, these data support that any of these Kir subunits could be involved in the cardioprotection afforded by diazoxide. However, these data suggest that mitochondrial swelling by diazoxide does not involve Kir1.1, 3.1, or 3.4. ..
  68. Zhang H, Zhu S, John R, Li R, Liu H, Ye Q. Habitat filtering and exclusion of weak competitors jointly explain fern species assemblage along a light and water gradient. Sci Rep. 2017;7:298 pubmed publisher
    ..photosynthetic nutrient efficiency (PNUE and PPUE) and water use efficiency as measured by carbon isotope ratio (CIR), and constitute important determinants of fern community assembly in all three forests...
  69. Englert H, Heitsch H, Gerlach U, Knieps S. Blockers of the ATP-sensitive potassium channel SUR2A/Kir6.2: a new approach to prevent sudden cardiac death. Curr Med Chem Cardiovasc Hematol Agents. 2003;1:253-71 pubmed
    The cardiac ATP sensitive potassium channel (K(ATP) channel) SUR2A/Kir6.2 is an emerging target for antiarrhythmic intervention...
  70. Flagg T, Remedi M, Masia R, Gomes J, McLerie M, Lopatin A, et al. Transgenic overexpression of SUR1 in the heart suppresses sarcolemmal K(ATP). J Mol Cell Cardiol. 2005;39:647-56 pubmed
    ..2 suppresses the functional expression of K(ATP) from optimized dimeric SUR1-Kir6.2. Thus, the graded effect of SUR1 expression in the intact heart appears to demonstrate an in vivo requirement for 1:1 expression ratio of Kir6.2 and SURx...
  71. Gier B, Krippeit Drews P, Sheiko T, Aguilar Bryan L, Bryan J, Dufer M, et al. Suppression of KATP channel activity protects murine pancreatic beta cells against oxidative stress. J Clin Invest. 2009;119:3246-56 pubmed publisher
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    ..Two recurrent mutations (G151R and L168R) in the potassium channel gene KCNJ5 have been identified that affect the Kir3...
  73. Fernandes Rosa F, Williams T, Riester A, Steichen O, Beuschlein F, Boulkroun S, et al. Genetic spectrum and clinical correlates of somatic mutations in aldosterone-producing adenoma. Hypertension. 2014;64:354-61 pubmed publisher
    Primary aldosteronism is the most common form of secondary hypertension. Somatic mutations in KCNJ5, ATP1A1, ATP2B3, and CACNA1D have been described in aldosterone-producing adenomas (APAs)...
  74. Nanba K, Omata K, Tomlins S, Giordano T, Hammer G, Rainey W, et al. Double adrenocortical adenomas harboring independent KCNJ5 and PRKACA somatic mutations. Eur J Endocrinol. 2016;175:K1-6 pubmed publisher
    ..Targeted next-generation sequencing (NGS) detected novel KCNJ5 gene mutations (p.T148I/T149S, present in the same reads) and a PRKACA gene hotspot mutation (p...
  75. Mino S, Nakagawa S, Makita H, Toki T, Miyazaki J, Sievert S, et al. Endemicity of the cosmopolitan mesophilic chemolithoautotroph Sulfurimonas at deep-sea hydrothermal vents. ISME J. 2017;11:909-919 pubmed publisher
    ..different geographical regions (Okinawa Trough (OT), Mariana Volcanic Arc and Trough (MVAT), Central Indian Ridge (CIR) and Mid-Atlantic Ridge (MAR))...
  76. Caroccia B, Prisco S, Seccia T, Piazza M, Maiolino G, Rossi G. Macrolides Blunt Aldosterone Biosynthesis: A Proof-of-Concept Study in KCNJ5 Mutated Adenoma Cells Ex Vivo. Hypertension. 2017;70:1238-1242 pubmed publisher
    ..4 (KCNJ5) in 30% to 70% of cases, typically the more florid phenotypes...
  77. Calloe K, Ravn L, Schmitt N, Sui J, Duno M, Haunso S, et al. Characterizations of a loss-of-function mutation in the Kir3.4 channel subunit. Biochem Biophys Res Commun. 2007;364:889-95 pubmed
    ..4-G247R is compensated in vivo. This may explain the lack of clear clinical manifestations and further studies are necessary to elucidate if mutations in Kir3.4 are predisposing AF. ..
  78. Yang Y, Yang Y, Liang B, Liu J, Li J, Grunnet M, et al. Identification of a Kir3.4 mutation in congenital long QT syndrome. Am J Hum Genet. 2010;86:872-80 pubmed
    ..4, encoded by the KCNJ5 gene. The Kir3...
  79. Fatima N, Schooley J, Claycomb W, Flagg T. Promoter DNA methylation regulates murine SUR1 (Abcc8) and SUR2 (Abcc9) expression in HL-1 cardiomyocytes. PLoS ONE. 2012;7:e41533 pubmed publisher
  80. Murakami M, Yoshimoto T, Nakano Y, Tsuchiya K, Minami I, Bouchi R, et al. Expression of inflammation-related genes in aldosterone-producing adenomas with KCNJ5 mutation. Biochem Biophys Res Commun. 2016;476:614-619 pubmed publisher
    ..We revealed that mRNA expression patterns of the inflammation-related genes depended on a KCNJ5 somatic mutation...
  81. Su J, Liu J, Yan X, Zhang Y, Zhang J, Zhang L, et al. Cytoprotective Effect of the UCP2-SIRT3 Signaling Pathway by Decreasing Mitochondrial Oxidative Stress on Cerebral Ischemia-Reperfusion Injury. Int J Mol Sci. 2017;18: pubmed publisher
    ..brain function, with more severe dysfunctional problems developing, called cerebral ischemia-reperfusion injury (CIR)...
  82. Gao S, Stein S, Petre E, Shady W, Durack J, Ridge C, et al. Micropapillary and/or Solid Histologic Subtype Based on Pre-Treatment Biopsy Predicts Local Recurrence After Thermal Ablation of Lung Adenocarcinoma. Cardiovasc Intervent Radiol. 2018;41:253-259 pubmed publisher
    ..Cumulative incidence of recurrence (CIR) was calculated using competing risks analysis and compared across groups using Fine and Grey method with ..
  83. Plummer H, Dhar M, Cekanova M, Schuller H. Expression of G-protein inwardly rectifying potassium channels (GIRKs) in lung cancer cell lines. BMC Cancer. 2005;5:104 pubmed
    ..Stimulation of GIRK channels and beta-adrenergic signaling may activate similar signaling pathways in both SCLC and breast cancer, but lead to different results. ..
  84. Dutta R, Welander J, Brauckhoff M, Walz M, Alesina P, Arnesen T, et al. Complementary somatic mutations of KCNJ5, ATP1A1, and ATP2B3 in sporadic aldosterone producing adrenal adenomas. Endocr Relat Cancer. 2014;21:L1-4 pubmed publisher
  85. Gomez L, Wigg K, Zhang K, Lopez L, Sandor P, Malone M, et al. Association of the KCNJ5 gene with Tourette Syndrome and Attention-Deficit/Hyperactivity Disorder. Genes Brain Behav. 2014;13:535-42 pubmed publisher
    ..To identify the risk gene within the region we studied the potassium inwardly-rectifying channel J5 (KCNJ5) gene in a sample of 170 nuclear families with TS...
  86. Sibai H, Falcone U, Deotare U, Michelis F, Uhm J, Gupta V, et al. Myeloablative versus Reduced-Intensity Conditioning in Patients with Myeloid Malignancies: A Propensity Score-Matched Analysis. Biol Blood Marrow Transplant. 2016;22:2270-2275 pubmed publisher
    ..171) or chronic GVHD (P?=?.605) at 1 year. The cumulative incidence of relapse (CIR) at 2 years was statistically significantly different between the 2 groups, however (RIC, 26.1?±?2.6%; MAC, 14...
  87. Hung M, Ekwueme D, Rim S, White A. Racial/ethnicity disparities in invasive breast cancer among younger and older women: An analysis using multiple measures of population health. Cancer Epidemiol. 2016;45:112-118 pubmed publisher
    ..measures of population health: life expectancy (LE), expected years of life lost (EYLL), cumulative incidence rate (CIR), and incidence and mortality rate ratios (IRR and MRR)...
  88. Li N, Hansen B, Csepe T, Zhao J, Ignozzi A, Sul L, et al. Redundant and diverse intranodal pacemakers and conduction pathways protect the human sinoatrial node from failure. Sci Transl Med. 2017;9: pubmed publisher
    ..to adenosine challenge is orchestrated by heterogeneous differences in adenosine A1 receptors and downstream GIRK4 channel protein expressions across the SAN complex...
  89. Piper T, Putz M, Schanzer W, Pop V, McLeod M, Uduwela D, et al. Epiandrosterone sulfate prolongs the detectability of testosterone, 4-androstenedione, and dihydrotestosterone misuse by means of carbon isotope ratio mass spectrometry. Drug Test Anal. 2017;9:1695-1703 pubmed publisher
    ..studies on the capability of EPIA_S to extend the detection of T and T analogue misuse by carbon isotope ratio (CIR) mass spectrometry in sports drug testing...
  90. Boyer I, Bergfeld W, Heldreth B, Fiume M, Gill L. The Cosmetic Ingredient Review Program-Expert Safety Assessments of Cosmetic Ingredients in an Open Forum. Int J Toxicol. 2017;36:5S-13S pubmed publisher
    The Cosmetic Ingredient Review (CIR) is a nonprofit program to assess the safety of ingredients in personal care products in an open, unbiased, and expert manner...
  91. Kennedy M, Nemec J, Corey S, Wickman K, Clapham D. GIRK4 confers appropriate processing and cell surface localization to G-protein-gated potassium channels. J Biol Chem. 1999;274:2571-82 pubmed
    GIRK1 and GIRK4 subunits combine to form the heterotetrameric acetylcholine-activated potassium current (IKACh) channel in pacemaker cells of the heart. The channel is activated by direct binding of G-protein Gbetagamma subunits...
  92. Lee J, Kim M. The distribution of calbindin-D28k, parvalbumin, and calretinin immunoreactivity in the inferior colliculus of circling mouse. Anat Cell Biol. 2017;50:230-238 pubmed publisher
    ..In this trial, the inner ear organs were not so damaged to cause the hearing deficit of circling (cir/cir) mouse at 18 postnatal day (P18) though auditory brainstem response data indicated hearing loss of cir/cir mice ..