KCNJ4

Summary

Gene Symbol: KCNJ4
Description: potassium voltage-gated channel subfamily J member 4
Alias: HIR, HIRK2, HRK1, IRK-3, IRK3, Kir2.3, inward rectifier potassium channel 4, hippocampal inward rectifier potassium channel, inward rectifier K(+) channel Kir2.3, potassium channel, inwardly rectifying subfamily J, member 4, potassium inwardly-rectifying channel, subfamily J, member 4
Species: human
Products:     KCNJ4

Top Publications

  1. Périer F, Radeke C, Vandenberg C. Primary structure and characterization of a small-conductance inwardly rectifying potassium channel from human hippocampus. Proc Natl Acad Sci U S A. 1994;91:6240-4 pubmed
    We have isolated a human hippocampus cDNA that encodes an inwardly rectifying potassium channel, termed HIR (hippocampal inward rectifier), with strong rectification characteristics...
  2. Yan X, Zhou H, Zhang J, Shi C, Xie X, Wu Y, et al. Molecular mechanism of inward rectifier potassium channel 2.3 regulation by tax-interacting protein-1. J Mol Biol. 2009;392:967-76 pubmed publisher
    ..3 PDZ-binding motif RRESAI dynamically regulates the Kir2.3/TIP-1 association in heterologous HEK293T cells. These data suggest that TIP-1 may act as an important regulator for the endocytic pathway of Kir2.3. ..
  3. Topfedaisi Ozkan N, Meydanlı M, Sarı M, Demirkiran F, Kahramanoglu I, Bese T, et al. Factors associated with survival after relapse in patients with low-risk endometrial cancer treated with surgery alone. J Gynecol Oncol. 2017;28:e65 pubmed publisher
    ..4%) out of 67 women with recurrent low-risk EC were qualified as high-intermediate risk (HIR)...
  4. Li Z, Liu S, Xu L, Xu S, Ni G. Effects of treadmill running with different intensity on rat subchondral bone. Sci Rep. 2017;7:1977 pubmed publisher
    ..lower porosity, while trabecular bone became more plate-like and denser with higher BMD in high-intensity running (HIR) group. Further, HIR led to highly remodeled, less mineralized, and stiffer subchondral plate and trabecular bone...
  5. Matamoros M, Pérez Hernández M, Guerrero Serna G, Amorós I, Barana A, Núñez M, et al. Nav1.5 N-terminal domain binding to α1-syntrophin increases membrane density of human Kir2.1, Kir2.2 and Nav1.5 channels. Cardiovasc Res. 2016;110:279-90 pubmed publisher
    ..5 channels in Nav1.5-Kir2.x-reciprocal interactions and suggest that the molecular mechanisms controlling atrial and ventricular cellular excitability may be different. ..
  6. Sakai N, Yabuuchi H, Kondo M, Kojima T, Nagatomo K, Kawanami S, et al. Volumetric measurement of artificial pure ground-glass nodules at low-dose CT: Comparisons between hybrid iterative reconstruction and filtered back projection. Eur J Radiol. 2015;84:2654-62 pubmed publisher
    To compare hybrid iterative reconstruction (HIR) with filtered back projection (FBP) in the volumetry of artificial pure ground-glass nodules (GGNs) with low-dose computed tomography (CT). Artificial GGNs (10 mm-diameter, 523...
  7. Goto Y, Yamagishi Y, Shintomi Kawamura M, Abe M, Tanno Y, Watanabe Y. Pds5 Regulates Sister-Chromatid Cohesion and Chromosome Bi-orientation through a Conserved Protein Interaction Module. Curr Biol. 2017;27:1005-1012 pubmed publisher
    ..relies largely on histone H3-T3 phosphorylation (H3-pT3), which is mediated by the mitotic histone kinase Haspin/Hrk1 [3-5]...
  8. Boado R, Pardridge W. Brain and Organ Uptake in the Rhesus Monkey in Vivo of Recombinant Iduronidase Compared to an Insulin Receptor Antibody-Iduronidase Fusion Protein. Mol Pharm. 2017;14:1271-1277 pubmed publisher
    ..of IDUA may be enhanced by fusion of the enzyme to a monoclonal antibody (mAb) against the human insulin receptor (HIR)...
  9. Iyama Y, Nakaura T, Kidoh M, Kiyota N, Uemura S, Harada K, et al. Effects of a high-pitch protocol and a hybrid iterative reconstruction algorithm on image quality of cerebral subtracted 3D CT angiography. Jpn J Radiol. 2015;33:687-93 pubmed publisher
    ..of 3D-computed tomography angiography (3D-CTA) with a high-pitch protocol and a hybrid iterative reconstruction (HIR). This was a prospective study and thirty patients were scanned at a 0...
  10. Taylor C, An S, Kankanamalage S, Stippec S, Earnest S, Trivedi A, et al. OSR1 regulates a subset of inward rectifier potassium channels via a binding motif variant. Proc Natl Acad Sci U S A. 2018;115:3840-3845 pubmed publisher
    ..3 channel activity by increasing their plasma membrane localization. Regulation of members of the inward rectifier K+ channel family adds functional and mechanistic insight into the physiological impact of the WNK pathway. ..

Detail Information

Publications82

  1. Périer F, Radeke C, Vandenberg C. Primary structure and characterization of a small-conductance inwardly rectifying potassium channel from human hippocampus. Proc Natl Acad Sci U S A. 1994;91:6240-4 pubmed
    We have isolated a human hippocampus cDNA that encodes an inwardly rectifying potassium channel, termed HIR (hippocampal inward rectifier), with strong rectification characteristics...
  2. Yan X, Zhou H, Zhang J, Shi C, Xie X, Wu Y, et al. Molecular mechanism of inward rectifier potassium channel 2.3 regulation by tax-interacting protein-1. J Mol Biol. 2009;392:967-76 pubmed publisher
    ..3 PDZ-binding motif RRESAI dynamically regulates the Kir2.3/TIP-1 association in heterologous HEK293T cells. These data suggest that TIP-1 may act as an important regulator for the endocytic pathway of Kir2.3. ..
  3. Topfedaisi Ozkan N, Meydanlı M, Sarı M, Demirkiran F, Kahramanoglu I, Bese T, et al. Factors associated with survival after relapse in patients with low-risk endometrial cancer treated with surgery alone. J Gynecol Oncol. 2017;28:e65 pubmed publisher
    ..4%) out of 67 women with recurrent low-risk EC were qualified as high-intermediate risk (HIR)...
  4. Li Z, Liu S, Xu L, Xu S, Ni G. Effects of treadmill running with different intensity on rat subchondral bone. Sci Rep. 2017;7:1977 pubmed publisher
    ..lower porosity, while trabecular bone became more plate-like and denser with higher BMD in high-intensity running (HIR) group. Further, HIR led to highly remodeled, less mineralized, and stiffer subchondral plate and trabecular bone...
  5. Matamoros M, Pérez Hernández M, Guerrero Serna G, Amorós I, Barana A, Núñez M, et al. Nav1.5 N-terminal domain binding to α1-syntrophin increases membrane density of human Kir2.1, Kir2.2 and Nav1.5 channels. Cardiovasc Res. 2016;110:279-90 pubmed publisher
    ..5 channels in Nav1.5-Kir2.x-reciprocal interactions and suggest that the molecular mechanisms controlling atrial and ventricular cellular excitability may be different. ..
  6. Sakai N, Yabuuchi H, Kondo M, Kojima T, Nagatomo K, Kawanami S, et al. Volumetric measurement of artificial pure ground-glass nodules at low-dose CT: Comparisons between hybrid iterative reconstruction and filtered back projection. Eur J Radiol. 2015;84:2654-62 pubmed publisher
    To compare hybrid iterative reconstruction (HIR) with filtered back projection (FBP) in the volumetry of artificial pure ground-glass nodules (GGNs) with low-dose computed tomography (CT). Artificial GGNs (10 mm-diameter, 523...
  7. Goto Y, Yamagishi Y, Shintomi Kawamura M, Abe M, Tanno Y, Watanabe Y. Pds5 Regulates Sister-Chromatid Cohesion and Chromosome Bi-orientation through a Conserved Protein Interaction Module. Curr Biol. 2017;27:1005-1012 pubmed publisher
    ..relies largely on histone H3-T3 phosphorylation (H3-pT3), which is mediated by the mitotic histone kinase Haspin/Hrk1 [3-5]...
  8. Boado R, Pardridge W. Brain and Organ Uptake in the Rhesus Monkey in Vivo of Recombinant Iduronidase Compared to an Insulin Receptor Antibody-Iduronidase Fusion Protein. Mol Pharm. 2017;14:1271-1277 pubmed publisher
    ..of IDUA may be enhanced by fusion of the enzyme to a monoclonal antibody (mAb) against the human insulin receptor (HIR)...
  9. Iyama Y, Nakaura T, Kidoh M, Kiyota N, Uemura S, Harada K, et al. Effects of a high-pitch protocol and a hybrid iterative reconstruction algorithm on image quality of cerebral subtracted 3D CT angiography. Jpn J Radiol. 2015;33:687-93 pubmed publisher
    ..of 3D-computed tomography angiography (3D-CTA) with a high-pitch protocol and a hybrid iterative reconstruction (HIR). This was a prospective study and thirty patients were scanned at a 0...
  10. Taylor C, An S, Kankanamalage S, Stippec S, Earnest S, Trivedi A, et al. OSR1 regulates a subset of inward rectifier potassium channels via a binding motif variant. Proc Natl Acad Sci U S A. 2018;115:3840-3845 pubmed publisher
    ..3 channel activity by increasing their plasma membrane localization. Regulation of members of the inward rectifier K+ channel family adds functional and mechanistic insight into the physiological impact of the WNK pathway. ..
  11. Wu W, Yao H, Zhao H, Wang J, Haddad G. Down-regulation of Inwardly Rectifying K+ Currents in Astrocytes Derived from Patients with Monge's Disease. Neuroscience. 2018;374:70-79 pubmed publisher
  12. Bosschieter J, Nieuwenhuijzen J, van Ginkel T, Vis A, Witte B, Newling D, et al. Value of an Immediate Intravesical Instillation of Mitomycin C in Patients with Non-muscle-invasive Bladder Cancer: A Prospective Multicentre Randomised Study in 2243 patients. Eur Urol. 2018;73:226-232 pubmed publisher
    ..Patients were categorised in low-risk (LOR), intermediate-risk (IMR), and high-risk (HIR) groups. Total numbers of instillations in these groups were 1, 9, and 15, respectively...
  13. Tanabe Y, Kido T, Kurata A, Fukuyama N, Yokoi T, Kido T, et al. Impact of knowledge-based iterative model reconstruction on myocardial late iodine enhancement in computed tomography and comparison with cardiac magnetic resonance. Int J Cardiovasc Imaging. 2017;33:1609-1618 pubmed publisher
    ..contrast medium and reconstructed with filtered back projection (FBP), a hybrid iterative reconstruction (HIR), and IMR. The signal-to-noise ratio (SNR) and contrast-to-noise ratio (CNR) were assessed...
  14. Huang H, Zhang G, Chen Y. Dual Hypervalent Iodine(III) Reagents and Photoredox Catalysis Enable Decarboxylative Ynonylation under Mild Conditions. Angew Chem Int Ed Engl. 2015;54:7872-6 pubmed publisher
    A combination of hypervalent iodine(III) reagents (HIR) and photoredox catalysis with visible light has enabled chemoselective decarboxylative ynonylation to construct ynones, ynamides, and ynoates...
  15. Pardridge W, Boado R, Giugliani R, Schmidt M. Plasma Pharmacokinetics of Valanafusp Alpha, a Human Insulin Receptor Antibody-Iduronidase Fusion Protein, in Patients with Mucopolysaccharidosis Type I. BioDrugs. 2018;32:169-176 pubmed publisher
    ..protein, valanafusp alpha, where the IgG domain is a monoclonal antibody (MAb) against the human insulin receptor (HIR)...
  16. Hotter B, Ostwaldt A, Levichev Connolly A, Rozanski M, Audebert H, Fiebach J. Natural course of total mismatch and predictors for tissue infarction. Neurology. 2015;85:770-5 pubmed publisher
    ..assessed patients presenting with total mismatch and hypothesized that hypoperfusion intensity ratio (HIR), severity of stroke, and occlusion of blood vessel are predictors of tissue fate...
  17. Raphemot R, Swale D, Dadi P, Jacobson D, Cooper P, Wojtovich A, et al. Direct activation of β-cell KATP channels with a novel xanthine derivative. Mol Pharmacol. 2014;85:858-65 pubmed publisher
    ..VU0071063 represents a novel tool/compound for investigating β-cell physiology, KATP channel gating, and a new chemical scaffold for developing improved activators with medicinal chemistry. ..
  18. Gupta V, McGunigal M, Prasad Hayes M, Kalir T, Liu J. Adjuvant radiation therapy is associated with improved overall survival in high-intermediate risk stage I endometrial cancer: A national cancer data base analysis. Gynecol Oncol. 2017;144:119-124 pubmed publisher
    Adjuvant radiation therapy (RT) was shown to improve local control in patients with high-intermediate risk (HIR) stage I endometrial cancer (EC) in randomized trials...
  19. Ouldamer L, Bendifallah S, Body G, Canlorbe G, Touboul C, Graesslin O, et al. Call for Surgical Nodal Staging in Women with ESMO/ESGO/ESTRO High-Intermediate Risk Endometrial Cancer: A Multicentre Cohort Analysis from the FRANCOGYN Study Group. Ann Surg Oncol. 2017;24:1660-1666 pubmed publisher
    ..amp; Oncology (ESTRO) classification for endometrial cancer (EC) now includes a high-intermediate risk (HIR) group of recurrence due to the adverse prognostic role of lymphovascular space involvement (LVSI) and grade 3 for ..
  20. Horakova Z, Matejovic P, Pasek M, Hosek J, Simurdova M, Simurda J, et al. Effect of ethanol and acetaldehyde at clinically relevant concentrations on atrial inward rectifier potassium current IK1: separate and combined effect. J Physiol Pharmacol. 2016;67:339-51 pubmed
    ..1% on average. We conclude that ethanol and even more acetaldehyde affected IK1 at clinically relevant concentrations if applied separately. Their combined effect did not significantly differ from the effect of ethanol alone. ..
  21. Li X, Ortega B, Kim B, Welling P. A Common Signal Patch Drives AP-1 Protein-dependent Golgi Export of Inwardly Rectifying Potassium Channels. J Biol Chem. 2016;291:14963-72 pubmed publisher
    ..Here we explore this idea, focusing on two structurally and functionally divergent Kir family members, Kir2.3 (KCNJ4) and Kir4.1/5.1 (KCNJ10/16), which have ?50% amino identity...
  22. Reiter C, Heise F, Chung H, Ehrenhofer Murray A. A link between Sas2-mediated H4 K16 acetylation, chromatin assembly in S-phase by CAF-I and Asf1, and nucleosome assembly by Spt6 during transcription. FEMS Yeast Res. 2015;15: pubmed publisher
    ..chromatin at genes upon repression, and this deposition requires the histone chaperone Spt6, but not CAF-I, Asf1, HIR or Rtt106...
  23. Nakaura T, Iyama Y, Kidoh M, Yokoyama K, Oda S, Tokuyasu S, et al. Comparison of iterative model, hybrid iterative, and filtered back projection reconstruction techniques in low-dose brain CT: impact of thin-slice imaging. Neuroradiology. 2016;58:245-51 pubmed publisher
    ..brain CT and reconstructed axial images with filtered back projection (FBP), hybrid iterative reconstruction (HIR) and IMR with 1 and 5 mm slice thicknesses...
  24. Anderson H, Kagansky A, Wardle J, Rappsilber J, Allshire R, Whitehall S. Silencing mediated by the Schizosaccharomyces pombe HIRA complex is dependent upon the Hpc2-like protein, Hip4. PLoS ONE. 2010;5:e13488 pubmed publisher
    HIRA (or Hir) proteins are conserved histone chaperones that function in multi-subunit complexes to mediate replication-independent nucleosome assembly...
  25. Liu C, Li W, Zhong Y, Dong X, Hu H, Tian X, et al. Fine mapping of qhir8 affecting in vivo haploid induction in maize. Theor Appl Genet. 2015;128:2507-15 pubmed publisher
    ..In previous QTL mapping research, qhir8 besides qhir1 significantly affected haploid induction rate (HIR)...
  26. Tscherner M, Zwolanek F, Jenull S, Sedlazeck F, Petryshyn A, Frohner I, et al. The Candida albicans Histone Acetyltransferase Hat1 Regulates Stress Resistance and Virulence via Distinct Chromatin Assembly Pathways. PLoS Pathog. 2015;11:e1005218 pubmed publisher
    ..stress resistance and azole tolerance are phenocopied by the loss of histone chaperone complexes CAF-1 and HIR, respectively, suggesting a central role for NuB4 in the delivery of histones destined for chromatin assembly via ..
  27. Cai W, Hu C, Hu S, Wang X, Gong J, Zhang W, et al. Feasibility study of iterative model reconstruction combined with low tube voltage, low iodine load, and low iodine delivery rate in craniocervical CT angiography. Clin Radiol. 2018;73:217.e1-217.e6 pubmed publisher
    ..5 ml/s; hybrid iterative reconstruction (HIR) for group B1 and IMR for group B2...
  28. Xia P, Li L, Qi R, Shi J, Ju W, Chen M. Electrical and histological remodeling of the pulmonary vein in 2K1C hypertensive rats: Indication of initiation and maintenance of atrial fibrillation. Anatol J Cardiol. 2018;: pubmed publisher
    ..5 and Kir2.1 and increase in interstitial fibrosis. These observations may clarify the role of PVs in the mechanistic association between hypertension and AF. ..
  29. Therasakvichya S, Kuljarusnont S, Petsuksiri J, Chaopotong P, Achariyapota V, Srichaikul P, et al. Clinical outcomes of stage I endometrial carcinoma patients treated with surgery alone: Siriraj Hospital experiences. J Gynecol Oncol. 2016;27:e48 pubmed publisher
    ..Factors that appeared to be prognostic factors on univariate analyses were age and having high intermediate risk (HIR) (Gynecologic Oncology Group [GOG] 99 criteria), none of which showed significance in multivariate analysis...
  30. Laqmani A, Veldhoen S, Dulz S, Derlin T, Behzadi C, Schmidt Holtz J, et al. Reduced-dose abdominopelvic CT using hybrid iterative reconstruction in suspected left-sided colonic diverticulitis. Eur Radiol. 2016;26:216-24 pubmed publisher
    To assess the effect of hybrid iterative reconstruction (HIR) and filtered back projection (FBP) on abdominopelvic CT with reduced-dose (RD-APCT) in the evaluation of acute left-sided colonic diverticulitis (ALCD)...
  31. Han S, Jang H, Seu S, Cho H, Hwang Y, Kim J, et al. Hepatic ischemia/reperfusion injury disrupts the homeostasis of kidney primary cilia via oxidative stress. Biochim Biophys Acta. 2017;1863:1817-1828 pubmed publisher
    ..b>HIR induced damages to the liver and kidney with increases in ROS/oxidative stress...
  32. Scherer D, Schworm B, Seyler C, Xynogalos P, Scholz E, Thomas D, et al. Inhibition of inwardly rectifying Kir2.x channels by the novel anti-cancer agent gambogic acid depends on both pore block and PIP2 interference. Naunyn Schmiedebergs Arch Pharmacol. 2017;390:701-710 pubmed publisher
    ..x channel inhibition by GA may be relevant in patients with pre-existing cardiac disorders such as chronic heart failure or certain rhythm disorders and recommend a close cardiac monitoring for those patients when treated with GA. ..
  33. Koepple C, Scherer D, Seyler C, Scholz E, Thomas D, Katus H, et al. Dual Mechanism for Inhibition of Inwardly Rectifying Kir2.x Channels by Quinidine Involving Direct Pore Block and PIP2-interference. J Pharmacol Exp Ther. 2017;361:209-218 pubmed publisher
    ..Thus, we conclude that inhibition of Kir2.x channels by quinidine is mediated by joint modes of action involving direct cytoplasmic pore block and an impaired channel stabilization via interference with PIP2. ..
  34. Vaidyanathan R, Van Ert H, Haq K, Morotti S, Esch S, McCune E, et al. Inward Rectifier Potassium Channels (Kir2.x) and Caveolin-3 Domain-Specific Interaction: Implications for Purkinje Cell-Dependent Ventricular Arrhythmias. Circ Arrhythm Electrophysiol. 2018;11:e005800 pubmed publisher
    ..x homomeric and heteromeric channels. Mathematical Purkinje cell model incorporating experimental findings suggests delayed after-depolarization-type triggered activity as a possible arrhythmia mechanism. ..
  35. Hamstra Wright K, Earl Boehm J, Bolgla L, Emery C, Ferber R. Individuals With Patellofemoral Pain Have Less Hip Flexibility Than Controls Regardless of Treatment Outcome. Clin J Sport Med. 2017;27:97-103 pubmed publisher
    ..flexibility-passive goniometry (degrees): hip adduction (HADD), hip external rotation (HER), hip internal rotation (HIR), total hip rotation (HROT), hip extension (HEXT) were measured before and after the muscle strengthening treatment ..
  36. Amin A, Vishnoi N, Prochasson P. A global requirement for the HIR complex in the assembly of chromatin. Biochim Biophys Acta. 2013;1819:264-276 pubmed publisher
    ..In this review, we discuss the roles of an evolutionarily conserved histone chaperone known as the HIR/HIRA complex. In S...
  37. Brouwers B, Schrauwen Hinderling V, Jelenik T, Gemmink A, Havekes B, Bruls Y, et al. Metabolic disturbances of non-alcoholic fatty liver resemble the alterations typical for type 2 diabetes. Clin Sci (Lond). 2017;131:1905-1917 pubmed publisher
    ..Adipo-IRi (r=0.652, P<0.001), hepatic insulin resistance index (HIRi) (r=0.576, P=0.001), and ?Rd (r=-0.653, P<0...
  38. Sun X, Shi L, Luo Y, Yang W, Li H, Liang P, et al. Histogram-based normalization technique on human brain magnetic resonance images from different acquisitions. Biomed Eng Online. 2015;14:73 pubmed publisher
    ..the image are first rescaled to a range between the low intensity region (LIR) value and the high intensity region (HIR) value; and (2) histogram normalization (HN),where the histogram of low-quality image as input image is stretched ..
  39. Stupin A, Cosic A, Novak S, Vesel M, Jukic I, Popović B, et al. Reduced Dietary Selenium Impairs Vascular Function by Increasing Oxidative Stress in Sprague-Dawley Rat Aortas. Int J Environ Res Public Health. 2017;14: pubmed publisher
    ..Hypoxia-induced relaxation (HIR) (dominantly mediated by COX-1, 2), TBARS, and FRAP as well as GPx1 serum concentrations were similar between the ..
  40. Kubo Y, Adelman J, Clapham D, Jan L, Karschin A, Kurachi Y, et al. International Union of Pharmacology. LIV. Nomenclature and molecular relationships of inwardly rectifying potassium channels. Pharmacol Rev. 2005;57:509-26 pubmed
  41. Pardridge W. Delivery of Biologics Across the Blood-Brain Barrier with Molecular Trojan Horse Technology. BioDrugs. 2017;31:503-519 pubmed publisher
    ..The lead Trojan horse is a MAb against the human insulin receptor (HIR), and HIRMAb-derived fusion proteins have entered clinical trials for the treatment of brain disease.
  42. Cohen N, Brenman J, Snyder S, Bredt D. Binding of the inward rectifier K+ channel Kir 2.3 to PSD-95 is regulated by protein kinase A phosphorylation. Neuron. 1996;17:759-67 pubmed
    ..Stimulation of PKA in intact cells causes rapid dissociation of the channel from PSD-95. This work identifies a physiological mechanism for regulating ion channel interactions with the postsynaptic density. ..
  43. Alewine C, Olsen O, Wade J, Welling P. TIP-1 has PDZ scaffold antagonist activity. Mol Biol Cell. 2006;17:4200-11 pubmed
    ..3 channels lacking the PDZ-binding motif. TIP-1 is ubiquitously expressed, raising the possibility that TIP-1 may play a similar role in regulating the expression of other membrane proteins containing a type I PDZ ligand. ..
  44. Huang X, Lee S, Lu H, Sanders K, Koh S. Molecular and functional characterization of inwardly rectifying K+ currents in murine proximal colon. J Physiol. 2017;: pubmed publisher
    ..ICC expressed Kcnj2 (Kir2.1), Kcnj4 (Kir2.3), Kcnj14 (Kir2.4) and Kcnj5 (Kir3.4), Kcnj8 (Kir 6.1) and Kcnj11 (Kir6.2)...
  45. Agopian A, Mitchell L, Glessner J, Bhalla A, Sewda A, Hakonarson H, et al. Genome-wide association study of maternal and inherited loci for conotruncal heart defects. PLoS ONE. 2014;9:e96057 pubmed publisher
    ..3 (rs6140038, combined p = 1.0 × 10(-5)) and an inherited intronic variant in KCNJ4 at 22q13.1 (rs2267386, combined p = 9.8 × 10(-6)), as well as with a maternal variant in SLC22A24 at 11q12...
  46. Mason A, Jacobs B, Welling P. AP-2-dependent internalization of potassium channel Kir2.3 is driven by a novel di-hydrophobic signal. J Biol Chem. 2008;283:5973-84 pubmed publisher
    ..Altogether, the results indicate that Kir2.3 channels are marked for clathrin-dependent internalization from the plasma membrane by a novel AP-2-dependent signal. ..
  47. Preisig Müller R, Schlichthörl G, Goerge T, Heinen S, Brüggemann A, Rajan S, et al. Heteromerization of Kir2.x potassium channels contributes to the phenotype of Andersen's syndrome. Proc Natl Acad Sci U S A. 2002;99:7774-9 pubmed
    ..Our results suggest that differential tetramerization of the mutant allele of Kir2.1 with wild-type Kir2.1, Kir2.2, and Kir2.3 channels represents the molecular basis of the extraordinary pleiotropy of Andersen's syndrome...
  48. Arenillas J, Cortijo E, Garcia Bermejo P, Levy E, Jahan R, Goyal M, et al. Relative cerebral blood volume is associated with collateral status and infarct growth in stroke patients in SWIFT PRIME. J Cereb Blood Flow Metab. 2017;:271678X17740293 pubmed publisher
    ..to calculate mean relative cerebral blood volume (rCBV) in hypoperfused regions, and hypoperfusion index ratio (HIR)...
  49. Huang X, Gao Y, Qin J, Lu S. The mechanism of long non-coding RNA MEG3 for hepatic ischemia-reperfusion: Mediated by miR-34a/Nrf2 signaling pathway. J Cell Biochem. 2018;119:1163-1172 pubmed publisher
    To investigate the function of MEG3 in hepatic ischemia-reperfusion (HIR) progress, involving its association with the level of miR-34a during hypoxia-induced hypoxia re-oxygenation (H/R) in vitro. HIR mice model in vivo was established...
  50. Han S, Choi H, Kim J, Park J, Park K. IDH2 deficiency increases the liver susceptibility to ischemia-reperfusion injury via increased mitochondrial oxidative injury. Redox Biol. 2017;14:142-153 pubmed publisher
    ..Here, we investigated the role of IDH2 in hepatic ischemia-reperfusion (HIR)-associated mitochondrial injury using Idh2-knockout (Idh2-/-) mice and wild-type (Idh2+/+) ..
  51. Fang Y, Schram G, Romanenko V, Shi C, Conti L, Vandenberg C, et al. Functional expression of Kir2.x in human aortic endothelial cells: the dominant role of Kir2.2. Am J Physiol Cell Physiol. 2005;289:C1134-44 pubmed
    ..3 or dnKir2.4. These studies suggest that Kir2.2 and Kir2.1 are primary determinants of endogenous K(+) conductance in HAECs under resting conditions and that Kir2.2 provides the dominant conductance in these cells. ..
  52. Guerreiro J, Muir A, Ramachandran S, Thorner J, Sá Correia I. Sphingolipid biosynthesis upregulation by TOR complex 2-Ypk1 signaling during yeast adaptive response to acetic acid stress. Biochem J. 2016;473:4311-4325 pubmed
    ..Ypk1 phosphorylation and activation is necessary for acetic acid tolerance, and occurs independently of Hrk1, a protein kinase previously implicated in the cellular response to acetic acid...
  53. He Y, Pan Q, Li J, Chen H, Zhou Q, Hong K, et al. Kir2.3 knock-down decreases IK1 current in neonatal rat cardiomyocytes. FEBS Lett. 2008;582:2338-42 pubmed publisher
    ..knock-down: -5.03+/-0.24 pA/pF, n=5 vs. -1.16+/-0.19 pA/pF, n=7, P<0.001) in neonatal rat cardiomyocytes. The data suggest that Kir2.3 plays a potentially important role in I(K1) currents in neonatal rat cardiomyocytes. ..
  54. Budarf M, Périer F, Barnoski B, Bell C, Vandenberg C. Assignment of the human hippocampal inward rectifier potassium channel (HIR) gene to 22q13.1. Genomics. 1995;26:625-9 pubmed
  55. Cazorla M, Shegda M, Ramesh B, Harrison N, Kellendonk C. Striatal D2 receptors regulate dendritic morphology of medium spiny neurons via Kir2 channels. J Neurosci. 2012;32:2398-409 pubmed publisher
  56. Inanobe A, Fujita A, Ito M, Tomoike H, Inageda K, Kurachi Y. Inward rectifier K+ channel Kir2.3 is localized at the postsynaptic membrane of excitatory synapses. Am J Physiol Cell Physiol. 2002;282:C1396-403 pubmed
    ..Therefore, the Kir channel may be involved in formation of the resting membrane potential of the spines and, thus, would affect the response of N-methyl-D-aspartic acid receptor channels at the excitatory postsynaptic membrane. ..
  57. Hadziselimovic F, Gegenschatz Schmid K, Verkauskas G, Docampo Garcia M, Demougin P, Bilius V, et al. Gene Expression Changes Underlying Idiopathic Central Hypogonadism in Cryptorchidism with Defective Mini-Puberty. Sex Dev. 2016;10:136-46 pubmed publisher
    ..Seven were classified as belonging to the high infertility risk (HIR) and 8 to the low infertility risk (LIR) group...
  58. den Harder A, Willemink M, van Doormaal P, Wessels F, Lock M, Schilham A, et al. Radiation dose reduction for CT assessment of urolithiasis using iterative reconstruction: A prospective intra-individual study. Eur Radiol. 2017;: pubmed publisher
    To assess the performance of hybrid (HIR) and model-based iterative reconstruction (MIR) in patients with urolithiasis at reduced-dose computed tomography (CT)...
  59. Vilakazi C, Dubery I, Piater L. Identification of lipopolysaccharide-interacting plasma membrane-type proteins in Arabidopsis thaliana. Plant Physiol Biochem. 2017;111:155-165 pubmed publisher
    ..g. hypersensitive-induced response (HIR) proteins, jacalin-like lectin domain-containing protein and myrosinase-binding proteins)...
  60. Tang W, Yang X. Cloning a novel human brain inward rectifier potassium channel and its functional expression in Xenopus oocytes. FEBS Lett. 1994;348:239-43 pubmed
    We have cloned a novel inward rectifier K+ channel (hIRK2) from a human frontal cortex cDNA library. The amino acid sequence of hIRK2 shares 60% and 40% identity with the mouse IRK1 and the rat ROMK1 channels, respectively...
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    ..Given the commonality of signaling involving PLC-PKC-delta, we speculate that TGF-beta(1)-evoked depolarization may be an early signaling event related to gene transcription in astrocytes. ..
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    ..3. These results therefore indicate that Kir2.3 is directly modulated by PKC phosphorylation of its channel protein and threonine 53 is the PKC phosphorylation site in Kir2.3. ..
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    ..Therefore, CASK appears to be a central protein of a macromolecular complex that participates in trafficking and plasma membrane localization of Kir2 channels. ..
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    A complementary DNA encoding an inward rectifier K+ channel (HRK1) was isolated from human hippocampus using a 392-base pair cDNA (HHCMD37) as a probe...
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    ..The discovery identifies one component of the sorting machinery and provides evidence for a retention mechanism in a hierarchical basolateral trafficking program. ..
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    ..Here, we demonstrate a novel role for the replication-independent HIR histone chaperone complex in fungal morphogenesis...
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    ..and scheduled for elective cardiac surgery, were separated into the low inflammatory (LIR) and high inflammatory (HIR) response groups based on their PCT levels measured on the first postoperative day...
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    We sought to validate whether low dose CACS CT with hybrid IR (HIR) could replace standard dose filtered back projection (FBP). We enrolled 100 patients to undergo low dose CACS CT with HIR, in addition to routine full dose FBP...
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    ..potency as compared with insulin lispro and demonstrated greater selectivity for the human insulin receptor (hIR) as compared with the human insulin-like growth factor 1 receptor...
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    ..of iterative model reconstruction (IMR), filtered back projection (FBP), and hybrid iterative reconstruction (HIR) on coronary artery calcium (CAC) scoring. CAC scans of 30 consecutive patients (18 men and 12 women, age 70...
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    ..2a and RGS4 nor between Kir3.2a and Galphao. These data are discussed in terms of a model in which GABA(B) receptors, G proteins, RGS4 proteins and Kir3 channels are closely associated in a signalling complex. ..
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    ..The data provide molecular insight into the unique pH regulation of inward rectifier channels. ..
  78. Cohen N, Sha Q, Makhina E, Lopatin A, Linder M, Snyder S, et al. Inhibition of an inward rectifier potassium channel (Kir2.3) by G-protein betagamma subunits. J Biol Chem. 1996;271:32301-5 pubmed
    ..Channels encoded by Kir2.3 (HRK1/HIR/BIRK2/BIR11) were completely suppressed by co-expression with G-protein betagamma subunits, whereas channels ..
  79. Liu Y, Liu D, Heath L, Meyers D, Krafte D, Wagoner P, et al. Direct activation of an inwardly rectifying potassium channel by arachidonic acid. Mol Pharmacol. 2001;59:1061-8 pubmed
    ..1 and Kir2.3, the transmembrane and/or intracellular domains of Kir2.3 were essential for channel potentiation. These results argue for a direct mechanism of AA modulation of Kir2.3. ..
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    ..These results identify a direct association of Kir2.1, Kir2.2 and Kir2.3 with the MAGUK family member SAP97 that may form part of a macromolecular signaling complex in many different tissues. ..
  81. Nehring R, Wischmeyer E, Doring F, Veh R, Sheng M, Karschin A. Neuronal inwardly rectifying K(+) channels differentially couple to PDZ proteins of the PSD-95/SAP90 family. J Neurosci. 2000;20:156-62 pubmed
    ..3 channels by >50%. This inhibitory action of PSD-95, which predominantly affects the single-channel conductance, is likely attributable to a molecular association with additional internal interaction sites in the Kir2.3 protein. ..
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    ..bacteria has negatively influenced P dissolution, whereas the addition of acidophilic Heterotrophic Iron Reducing (HIR) bacteria has slightly increased P dissolution but they contributed to pH maintenance at lower levels compared to ..