Gene Symbol: KCNIP3
Description: potassium voltage-gated channel interacting protein 3
Alias: CSEN, DREAM, KCHIP3, calsenilin, A-type potassium channel modulatory protein 3, DRE-antagonist modulator, Kv channel interacting protein 3, calsenilin, calsenilin, presenilin-binding protein, EF hand transcription factor, kv channel-interacting protein 3, potassium channel interacting protein 3
Species: human
Products:     KCNIP3

Top Publications

  1. Buxbaum J, Choi E, Luo Y, Lilliehook C, Crowley A, Merriam D, et al. Calsenilin: a calcium-binding protein that interacts with the presenilins and regulates the levels of a presenilin fragment. Nat Med. 1998;4:1177-81 pubmed
    ..yeast two-hybrid system, we have identified a neuronal protein that binds calcium and presenilin, which we call calsenilin. Calsenilin interacts with both PS1 and PS2 in cultured cells, and can regulate the levels of a proteolytic ..
  2. Takimoto K, Yang E, Conforti L. Palmitoylation of KChIP splicing variants is required for efficient cell surface expression of Kv4.3 channels. J Biol Chem. 2002;277:26904-11 pubmed
    The Ca(2+)-binding proteins KChIP1-4 (KChIP3 is also known as DREAM and calsenilin) act as auxiliary subunits for voltage-gated K(+) channels in the Kv4 family...
  3. Ledo F, Kremer L, Mellstrom B, Naranjo J. Ca2+-dependent block of CREB-CBP transcription by repressor DREAM. EMBO J. 2002;21:4583-92 pubmed
    The calcium-binding protein DREAM binds specifically to DRE sites in the DNA and represses transcription of target genes. Derepression at DRE sites following PKA activation depends on a specific interaction between alphaCREM and DREAM...
  4. Gomez Villafuertes R, Torres B, Barrio J, Savignac M, Gabellini N, Rizzato F, et al. Downstream regulatory element antagonist modulator regulates Ca2+ homeostasis and viability in cerebellar neurons. J Neurosci. 2005;25:10822-30 pubmed
    ..of NCX3 by the Ca2+-modulated transcriptional repressor downstream regulatory element antagonist modulator (DREAM)...
  5. An W, Bowlby M, Betty M, Cao J, Ling H, Mendoza G, et al. Modulation of A-type potassium channels by a family of calcium sensors. Nature. 2000;403:553-6 pubmed
  6. Jo D, Kim M, Choi Y, Kim I, Song Y, Woo H, et al. Pro-apoptotic function of calsenilin/DREAM/KChIP3. FASEB J. 2001;15:589-91 pubmed
    ..Here we describe a novel pro-apoptotic function of calsenilin/DREAM/KChIP3...
  7. Osawa M, Tong K, Lilliehook C, Wasco W, Buxbaum J, Cheng H, et al. Calcium-regulated DNA binding and oligomerization of the neuronal calcium-sensing protein, calsenilin/DREAM/KChIP3. J Biol Chem. 2001;276:41005-13 pubmed
    b>Calsenilin/DREAM/KChIP3, a member of the recoverin branch of the EF-hand superfamily, interacts with presenilins, serves as a calcium-regulated transcriptional repressor, and interacts with A-type potassium channels...
  8. Sanz C, Horita M, Fernandez Luna J. Fas signaling and blockade of Bcr-Abl kinase induce apoptotic Hrk protein via DREAM inhibition in human leukemia cells. Haematologica. 2002;87:903-7 pubmed
    The apoptotic Bcl-2 family member Hrk is transcriptionally silenced via DREAM in hematopoietic progenitor cell lines, and is specifically induced after growth factor withdrawal...
  9. Shibata R, Misonou H, Campomanes C, Anderson A, Schrader L, Doliveira L, et al. A fundamental role for KChIPs in determining the molecular properties and trafficking of Kv4.2 potassium channels. J Biol Chem. 2003;278:36445-54 pubmed
    ..2 hydrophobic domain. These studies point to an essential role for KChIPs in determining both the biophysical and molecular characteristics of Kv4 channels and provide a molecular basis for the dramatic phenotype of KChIP knockout mice. ..

More Information

Publications113 found, 100 shown here

  1. Palczewska M, Casafont I, Ghimire K, Rojas A, Valencia A, Lafarga M, et al. Sumoylation regulates nuclear localization of repressor DREAM. Biochim Biophys Acta. 2011;1813:1050-8 pubmed publisher
    b>DREAM is a Ca(2+)-binding protein with specific functions in different cell compartments. In the nucleus, DREAM acts as a transcriptional repressor, although the mechanism that controls its nuclear localization is unknown...
  2. Carrión A, Mellstrom B, Naranjo J. Protein kinase A-dependent derepression of the human prodynorphin gene via differential binding to an intragenic silencer element. Mol Cell Biol. 1998;18:6921-9 pubmed
    ..Upon PKA stimulation, binding to the DRE is reduced and transcription increases. We propose a model for human prodynorphin activation through PKA-dependent derepression at the DRE site. ..
  3. Leissring M, Yamasaki T, Wasco W, Buxbaum J, Parker I, LaFerla F. Calsenilin reverses presenilin-mediated enhancement of calcium signaling. Proc Natl Acad Sci U S A. 2000;97:8590-3 pubmed
    ..Although the molecular mechanisms underlying these changes are not known, one candidate molecular mediator is calsenilin, a recently identified calcium-binding protein that associates with the C terminus of both PS1 and PS2...
  4. Ledo F, Carrión A, Link W, Mellstrom B, Naranjo J. DREAM-alphaCREM interaction via leucine-charged domains derepresses downstream regulatory element-dependent transcription. Mol Cell Biol. 2000;20:9120-6 pubmed
    ..Here, we show that a direct protein-protein interaction between DREAM and the CREM repressor isoform, alphaCREM, prevents binding of DREAM to the DRE and suggests a mechanism for ..
  5. Choi E, Zaidi N, Miller J, Crowley A, Merriam D, Lilliehook C, et al. Calsenilin is a substrate for caspase-3 that preferentially interacts with the familial Alzheimer's disease-associated C-terminal fragment of presenilin 2. J Biol Chem. 2001;276:19197-204 pubmed
    b>Calsenilin is a member of the recoverin family of neuronal calcium-binding proteins that we have previously shown to interact with presenilin 1 (PS1) and presenilin 2 (PS2) holoproteins...
  6. Lilliehook C, Chan S, Choi E, Zaidi N, Wasco W, Mattson M, et al. Calsenilin enhances apoptosis by altering endoplasmic reticulum calcium signaling. Mol Cell Neurosci. 2002;19:552-9 pubmed
    b>Calsenilin (also called DREAM and KChIP3), a member of the neuronal calcium sensor family, was isolated in a yeast two-hybrid screen using an apoptotic domain of presenilin 2 as bait...
  7. Matsuda M, Yamamoto T, Hirata M. Ca2+-dependent regulation of calcitonin gene expression by the transcriptional repressor DREAM. Endocrinology. 2006;147:4608-17 pubmed
    ..The downstream regulatory element (DRE) antagonist modulator (DREAM) was recently identified as a Ca(2+)-dependent transcriptional repressor...
  8. Carrión A, Link W, Ledo F, Mellstrom B, Naranjo J. DREAM is a Ca2+-regulated transcriptional repressor. Nature. 1999;398:80-4 pubmed
    ..Here we isolate a new transcriptional repressor, DRE-antagonist modulator (DREAM), which specifically binds to the DRE. DREAM contains four Ca2+-binding domains of the EF-hand type...
  9. Choi E, Miller J, Zaidi N, Salih E, Buxbaum J, Wasco W. Phosphorylation of calsenilin at Ser63 regulates its cleavage by caspase-3. Mol Cell Neurosci. 2003;23:495-506 pubmed
    b>Calsenilin is a member of the neuronal calcium sensor (NCS) family of proteins that interacts with the presenilins. Calsenilin has been found to act as a Kv4alpha channel interactor and as a transcriptional repressor...
  10. Savignac M, Pintado B, Gutierrez Adan A, Palczewska M, Mellstrom B, Naranjo J. Transcriptional repressor DREAM regulates T-lymphocyte proliferation and cytokine gene expression. EMBO J. 2005;24:3555-64 pubmed
    Downstream Regulatory Element Antagonist Modulator (DREAM) is a Ca2+-dependent transcriptional repressor expressed in the brain, thyroid gland and thymus...
  11. Cheng H, Pitcher G, Laviolette S, Whishaw I, Tong K, Kockeritz L, et al. DREAM is a critical transcriptional repressor for pain modulation. Cell. 2002;108:31-43 pubmed
    ..Here we show that the calcium-sensing protein DREAM is a transcriptional repressor involved in modulating pain...
  12. Zaidi N, Berezovska O, Choi E, Miller J, Chan H, Lilliehook C, et al. Biochemical and immunocytochemical characterization of calsenilin in mouse brain. Neuroscience. 2002;114:247-63 pubmed
    ..Here we describe the biochemical and immunohistochemical characterization of calsenilin, a novel calcium binding protein that we have previously shown to interact with presenilins 1 and 2, in mouse ..
  13. Pruunsild P, Timmusk T. Structure, alternative splicing, and expression of the human and mouse KCNIP gene family. Genomics. 2005;86:581-93 pubmed
    ..and alternative splicing of the human and mouse KCNIP genes, including novel splice variants for KCNIP1, KCNIP3, and KCNIP4, and show the expression of different KCNIP mRNAs in various mouse and human tissues and brain regions ..
  14. Di W, Jia M, Xu J, Li B, Liu Y. Exogenous Catalase and Pyruvate Dehydrogenase Improve Survival and Regeneration and Affect Oxidative Stress in Cryopreserved Dendrobium nobile Protocorm-like Bodies. Cryo Letters. 2017;38:228-238 pubmed
    ..Hamana Lake Dream' protocorm-like bodies (PLBs)...
  15. Rodhain F. [Arboviruses also have an American dream]. Bull Soc Pathol Exot. 2017;110:147-159 pubmed publisher
  16. Kruitwagen H, Westendorp B, Viebahn C, Post K, van Wolferen M, Oosterhoff L, et al. DYRK1A is a regulator of S phase entry in hepatic progenitor cells. Stem Cells Dev. 2017;: pubmed publisher
    ..DYRK1A inhibition impaired Dimerization Partner, RB-like, E2F and multi-vulva class B (DREAM) complex formation in HPCs and abolished its transcriptional repression on cell cycle progression...
  17. Bouwmeester M, Ruiter S, Lommelaars T, Sippel J, Hodemaekers H, van den Brandhof E, et al. Zebrafish embryos as a screen for DNA methylation modifications after compound exposure. Toxicol Appl Pharmacol. 2016;291:84-96 pubmed publisher
    ..analysis was performed for BPA exposed embryos using Digital Restriction Enzyme Analysis of Methylation (DREAM), which showed minimal wide scale effects on the genome, whereas potential informative markers were not confirmed ..
  18. Jung Y, St Louis E. Treatment of REM Sleep Behavior Disorder. Curr Treat Options Neurol. 2016;18:50 pubmed
    ..However, neither agent is likely to completely stop dream enactment behaviors, so choosing a moderate target dosage of melatonin 6 mg or clonazepam 0...
  19. Anand S, Patel H, Bhartiya D. Chemoablated mouse seminiferous tubular cells enriched for very small embryonic-like stem cells undergo spontaneous spermatogenesis in vitro. Reprod Biol Endocrinol. 2015;13:33 pubmed publisher
    ..However, obtaining functional gametes from pluripotent stem cells still remains a distant dream and major bottle-neck appears to be their inefficient differentiation into primordial germ cells (PGCs)...
  20. Kobayashi K, Suzuki T, Iwata E, Nakamichi N, Suzuki T, Chen P, et al. Transcriptional repression by MYB3R proteins regulates plant organ growth. EMBO J. 2015;34:1992-2007 pubmed publisher
    ..interaction assays, we identified some of the other conserved components of the multiprotein complexes, known as DREAM/dREAM in human and flies...
  21. Barone D, Henchcliffe C. Rapid eye movement sleep behavior disorder and the link to alpha-synucleinopathies. Clin Neurophysiol. 2018;129:1551-1564 pubmed publisher
    ..REM) sleep behavior disorder (RBD) involves REM sleep without atonia in conjunction with a recurrent nocturnal dream enactment behavior, with vocalizations such as shouting and screaming, and motor behaviors such as punching and ..
  22. Wei T, Weiler S, Tóth M, Sticht C, Lutz T, Thomann S, et al. YAP-dependent induction of UHMK1 supports nuclear enrichment of the oncogene MYBL2 and proliferation in liver cancer cells. Oncogene. 2019;: pubmed publisher
    ..By using BioID labeling and mass spectrometry, the dimerization partner, RB-like, E2F and multi-vulval class B (DREAM) complex constituent MYB proto-oncogene like 2 (MYBL2, B-MYB) was identified as a direct UHMK1 interaction partner...
  23. Blattner M, de Bruin G, Bucelli R, Day G. Sleep disturbances are common in patients with autoimmune encephalitis. J Neurol. 2019;: pubmed publisher
    ..New sleep complaints were reported by 19/26 (73%) AE patients, including gasping or snoring (9/19, 47%), dream enactment behavior (6/19, 32%), insomnia (5/19, 29%), hypersomnia (4/19, 21%), other parasomnias (4/19, 21%), and ..
  24. Boeve B, Silber M, Ferman T, Lin S, Benarroch E, Schmeichel A, et al. Clinicopathologic correlations in 172 cases of rapid eye movement sleep behavior disorder with or without a coexisting neurologic disorder. Sleep Med. 2013;14:754-62 pubmed publisher
    ..Eighty-two (48%) had RBD confirmed by PSG, 64 (37%) had a classic history of recurrent dream enactment behavior, and 26 (15%) screened positive for RBD by questionnaire...
  25. van Esterik J, Vitins A, Hodemaekers H, Kamstra J, Legler J, Pennings J, et al. Liver DNA methylation analysis in adult female C57BL/6JxFVB mice following perinatal exposure to bisphenol A. Toxicol Lett. 2015;232:293-300 pubmed publisher
    ..in control and 3000μg/kg body weight/day females with the digital restriction enzyme analysis of methylation (DREAM) assay revealed potential differences, that could, however, not be confirmed by bisulfite pyrosequencing...
  26. Szydlowski M, Kiliszek P, Sewastianik T, Jablonska E, Bialopiotrowicz E, Gorniak P, et al. FOXO1 activation is an effector of SYK and AKT inhibition in tonic BCR signal-dependent diffuse large B-cell lymphomas. Blood. 2016;127:739-48 pubmed publisher
    ..FOXO1 activation and HRK induction that involves caspase-dependent cleavage of HRK's transcriptional repressor DREAM. Because AKT in lymphoma cells can be regulated by other signals than BCR, we assessed the combined effects of the ..
  27. Dale A, Lortie Lussier M, De Koninck J. Ontogenetic patterns in the dreams of women across the lifespan. Conscious Cogn. 2015;37:214-24 pubmed publisher
    ..One dream per participant was scored by two independent judges using the method of content analysis...
  28. Vishwanathan A, Aiyer K, Chunduri L, Venkataramaniah K, Siva Sankara Sai S, Rao G. Carbon quantum dots shuttle electrons to the anode of a microbial fuel cell. 3 Biotech. 2016;6:228 pubmed publisher
    ..Formation of silver nanoparticles from silver nitrate upon addition of C-dots confirmed their reducing ability. DREAM assay using a mixed microbial culture containing C-dots showed a 172% increase in electron transfer activity and ..
  29. Larrodé P, Calvo A, Moreno Martínez L, de la Torre M, Moreno García L, Molina N, et al. DREAM-Dependent Activation of Astrocytes in Amyotrophic Lateral Sclerosis. Mol Neurobiol. 2018;55:1-12 pubmed publisher
    ..Downstream regulatory element antagonist modulator (DREAM) is a neuronal calcium-binding protein that plays multiple roles in the nucleus and cytosol...
  30. Di Pauli F, Stefani A, Holzknecht E, Brandauer E, Mitterling T, Holzinger B, et al. Dream Content in Patients With Sleep Apnea: A Prospective Sleep Laboratory Study. J Clin Sleep Med. 2017;: pubmed
    ..We hypothesized that respiratory events and subsequent oxygen desaturation act as an important physiological trigger and may thus influence dream content in patients with a sleep-related breathing disorder.
  31. Raz A, Amano Y, Timmermans S. Coming to terms with the imperfectly normal child: attitudes of Israeli parents of screen-positive infants regarding subsequent prenatal diagnosis. J Community Genet. 2019;10:41-50 pubmed publisher
    ..The conclusions challenge the common assertion that parents pursue the dream of the "perfect child" through prenatal diagnosis that "naturally" leads to selective abortion...
  32. Orlowski S, Comera C, Tercé F, Collet X. Lipid rafts: dream or reality for cholesterol transporters?. Eur Biophys J. 2007;36:869-85 pubmed
    ..Finally, these cholesterol transporters undergo regulated intracellular trafficking, with presumably some relationships to rafts which remain to be clarified...
  33. Kordower J. AAV2-Neurturin for Parkinson's Disease: What Lessons Have We Learned?. Methods Mol Biol. 2016;1382:485-90 pubmed publisher
    The dream that trophic factors could be effectively delivered and potently forestall and reverse the symptoms of Parkinson's disease (PD) has yet to be realized...
  34. Gugliuzza A. Intelligent Membranes: Dream or Reality?. Membranes (Basel). 2013;3:151-4 pubmed publisher
    ..Thus, the transfer of signals to collecting systems could allow continuous and real-time monitoring of data, events and/or processes. ..
  35. Kahan T, Claudatos S. Phenomenological features of dreams: Results from dream log studies using the Subjective Experiences Rating Scale (SERS). Conscious Cogn. 2016;41:159-76 pubmed publisher
    Self-ratings of dream experiences were obtained from 144 college women for 788 dreams, using the Subjective Experiences Rating Scale (SERS)...
  36. Rosignolo F, Sponziello M, Durante C, Puppin C, Mio C, Baldan F, et al. Expression of PAX8 Target Genes in Papillary Thyroid Carcinoma. PLoS ONE. 2016;11:e0156658 pubmed publisher
    ..ATP1B1, GPC3, KCNIP3, and PRLR transcript levels in tumor tissues were significantly lower in PTCs than in NT, whereas LCN2, LGALS1 and ..
  37. Wang J, Yan D, Dixon R, Wang Y. Deciphering the Principles of Bacterial Nitrogen Dietary Preferences: a Strategy for Nutrient Containment. MBio. 2016;7: pubmed publisher
    ..is considered to be evolutionarily advantageous for bacteria (as remarked by François Jacob, who said that the "dream" of every cell is to become two cells), we showed that negative-feedback loops in the regulatory system inhibit ..
  38. Díaz Véliz G, Mora G S, Escanero J. [Longitudinal perception of the educational environment in two medical schools with traditional curricula in Chile and Spain]. Rev Med Chil. 2016;144:1479-1485 pubmed publisher
    ..At both universities the overall mean scores of DREAM were significantly higher in students in their first year than those obtained in the fourth year (137.5/118...
  39. Sanchez N, Mills G, Mills Shaw K. Precision oncology: neither a silver bullet nor a dream. Pharmacogenomics. 2017;18:1525-1539 pubmed publisher
    ..Importantly, we must recognize that most targeted therapy approaches are in their infancy, with only monotherapy approaches being assessed and combination therapies likely being necessary to fulfill the promise of precision oncology...
  40. Chebouba L, Miannay B, Boughaci D, Guziolowski C. Discriminate the response of Acute Myeloid Leukemia patients to treatment by using proteomics data and Answer Set Programming. BMC Bioinformatics. 2018;19:59 pubmed publisher
    ..To show its effectiveness we evaluate our method on a dataset from the DREAM 9 challenge...
  41. Jang C, Choi J, Na Y, Jang B, Wasco W, Buxbaum J, et al. Calsenilin regulates presenilin 1/?-secretase-mediated N-cadherin ?-cleavage and ?-catenin signaling. FASEB J. 2011;25:4174-83 pubmed publisher
    ..The purpose of this study was to determine whether calsenilin, a presenilin-interacting protein, has a functional role in PS1/?-secretase-mediated N-cadherin ?-cleavage using ..
  42. García Quintanilla M, Pulido M, Carretero Ledesma M, McConnell M. Vaccines for Antibiotic-Resistant Bacteria: Possibility or Pipe Dream?. Trends Pharmacol Sci. 2016;37:143-52 pubmed publisher
  43. Geddes M, Tie Y, Gabrieli J, McGinnis S, Golby A, Whitfield Gabrieli S. Altered functional connectivity in lesional peduncular hallucinosis with REM sleep behavior disorder. Cortex. 2016;74:96-106 pubmed publisher
    ..atrial fibrillation developed abrupt-onset complex visual hallucinations with preserved insight and violent dream enactment behavior...
  44. Durán Agüero S, Arroyo Jofre P, Varas Standen C, Herrera Valenzuela T, Moya Cantillana C, Pereira Robledo R, et al. [SLEEP QUALITY, EXCESSIVE DAYTIME SLEEPINESS AND INSOMNIA IN CHILEAN PARALYMPIC ATHLETES]. Nutr Hosp. 2015;32:2832-7 pubmed publisher
    ..The studied variables measured up across two surveys of dream: the Questionnaire of Insomnia and the Pittsburgh Sleep Quality Index. the paralympic athletes sleep were 6...
  45. Jelinek J, Madzo J. DREAM: A Simple Method for DNA Methylation Profiling by High-throughput Sequencing. Methods Mol Biol. 2016;1465:111-27 pubmed publisher
    The digital restriction enzyme analysis of methylation (DREAM) is a simple method for DNA methylation analysis at tens of thousands of CpG sites across the genome...
  46. Porte H. Homing in on consciousness: Why is a dream conscious?. Behav Brain Sci. 2016;39:e192 pubmed publisher
    ..argue convincingly that consciousness is for adaptive voluntary action. What, then, is consciousness in a dream for? Two prior questions present themselves...
  47. Renard E, Place J, Benbrahim N, Diouri O, Farret A. [The artificial pancreas, a dream on the point of becoming reality]. Rev Infirm. 2017;66:35-37 pubmed publisher
    ..Today, the outpatient treatment of type 1 diabetes by an artificial pancreas is on the point of becoming reality. ..
  48. Chen F, Hableel G, Zhao E, Jokerst J. Multifunctional nanomedicine with silica: Role of silica in nanoparticles for theranostic, imaging, and drug monitoring. J Colloid Interface Sci. 2018;521:261-279 pubmed publisher
    ..nanomedicine that enters the human body to diagnose and treat disease without major surgery is a long-standing dream of nanomaterials scientists...
  49. Reisch N, Engler A, Aeschlimann A, Simmen B, Michel B, Gay R, et al. DREAM is reduced in synovial fibroblasts of patients with chronic arthritic pain: is it a suitable target for peripheral pain management?. Arthritis Res Ther. 2008;10:R60 pubmed publisher
    ..Interfering with the trans-repression effect of downstream regulatory element antagonist modulator (DREAM) on the transcription of the opioid dynorphin-encoding prodynorphin (pdyn) gene might enhance pain relief in the ..
  50. Taylor W. The global eradication of peste des petits ruminants (PPR) within 15 years--is this a pipe dream?. Trop Anim Health Prod. 2016;48:559-67 pubmed publisher
    ..Were such international cooperation to be forthcoming once more, the understanding, tools and experiences now on offer suggest that PPR could be controlled and eradicated far more rapidly than rinderpest. ..
  51. Kuliukas L, Duggan R, Lewis L, Hauck Y. Women's experience of intrapartum transfer from a Western Australian birth centre co-located to a tertiary maternity hospital. BMC Pregnancy Childbirth. 2016;16:33 pubmed publisher
    ..and b) Returning back to the comfort and familiarity of the birth centre; 4) Lost sense of self; and 5) Lost birth dream with subthemes a) Narrowing of options and b) Feeling of panic...
  52. Tse D, Wiggins C, Ivanov D, Brenner D, Hoffmann J, Mirkes C, et al. Volumetric imaging with homogenised excitation and static field at 9.4 T. MAGMA. 2016;29:333-45 pubmed publisher
    ..B0- and B1-mapping were done using a dual-echo GRE and transmit phase-encoded DREAM, respectively...
  53. Kuliukas L, Hauck Y, Lewis L, Duggan R. The woman, partner and midwife: An integration of three perspectives of labour when intrapartum transfer from a birth centre to a tertiary obstetric unit occurs. Women Birth. 2017;30:e125-e131 pubmed publisher
    ..The woman and partner shared two themes: 'Lost birth dream' and 'Grateful to return to a familiar environment'...
  54. Agarwal D, Gupta R, Awasthi S. Are Antimalarial Hybrid Molecules a Close Reality or a Distant Dream?. Antimicrob Agents Chemother. 2017;61: pubmed publisher
  55. Keller L, Offner D, Schwinté P, Morand D, Wagner Q, Gros C, et al. Active Nanomaterials to Meet the Challenge of Dental Pulp Regeneration. Materials (Basel). 2015;8:7461-7471 pubmed publisher
    ..The regeneration of the pulp tissue is the dream of many generations of dental surgeons and will revolutionize clinical practices...
  56. Hellström L, Madsen T, Nordentoft M, Bech P, Eplov L. Trajectories of Return to Work Among People on Sick Leave with Mood or Anxiety Disorders: Secondary Analysis from a Randomized Controlled Trial. J Occup Rehabil. 2018;28:666-677 pubmed publisher
    ..in the past 6 months" was measured after 1/2, 1, 1 ½ and 2 years, using data from a nationwide Danish register (DREAM)...
  57. Summerton J. Invention and Early History of Morpholinos: From Pipe Dream to Practical Products. Methods Mol Biol. 2017;1565:1-15 pubmed publisher
    ..Initial applications are expected to be custom cocktails of delivery-enabled Morpholinos for treating cancers. ..
  58. Paulson S, Barrett D, Bulkeley K, Naiman R. Dreaming: a gateway to the unconscious?. Ann N Y Acad Sci. 2017;1406:28-45 pubmed publisher
    ..and host of To the Best of Our Knowledge, moderated a discussion that included psychologist Deirdre Barrett, dream researcher Kelly Bulkeley, and psychologist and sleep/dream medicine specialist Rubin Naiman; they examined dreams ..
  59. Li J, Zhang Y. History of orthopaedics in China: a brief review. Int Orthop. 2018;42:713-717 pubmed publisher
    ..Orthopaedics is constantly evolving, and we need to strengthen the ability of independent innovation to achieve orthopaedic surgeons' Chinese dream, and better serve our patients.
  60. Coux R, Teixeira F, Lehmann R. L(3)mbt and the LINT complex safeguard cellular identity in the Drosophila ovary. Development. 2018;145: pubmed publisher
    ..we show that L(3)mbt function in the ovary is mediated through its co-factor Lint-1 but independently of the dREAM complex...
  61. An Z. Monoclonal antibodies - a proven and rapidly expanding therapeutic modality for human diseases. Protein Cell. 2010;1:319-330 pubmed publisher
    ..Antibody therapeutics provides fertile ground for protein scientists to fulfill the dream of personalized medicine through basic scientific discovery and technological innovation.
  62. Forni G. Vaccines for tumor prevention: a pipe dream?. J Infect Dev Ctries. 2015;9:600-8 pubmed publisher
    ..Also, the exploitation of tumor vaccines to prevent tumors in cohorts of people with a specific risk of cancer may become a fresh strategy with great potential to control tumor onset. ..
  63. Schmelowszky Ã. Converging Paradigms: A Reflection on Parallel Theoretical Developments in Psychoanalytic Metapsychology and Empirical Dream Research. Psychoanal Rev. 2016;103:551-63 pubmed publisher
    ..one can perceive a striking parallelism between the shifting perspective of leading representatives of empirical dream research concerning their conceptualization of dreaming and the paradigm shift within clinically based ..
  64. Laktionov P, Maksimov D, Romanov S, Antoshina P, Posukh O, White Cooper H, et al. Genome-wide analysis of gene regulation mechanisms during Drosophila spermatogenesis. Epigenetics Chromatin. 2018;11:14 pubmed publisher
    ..Intriguingly, tMAC is paralogous to the broadly expressed complex Myb-MuvB (MMB)/dREAM and Mip40 protein is shared by both complexes...
  65. Chang J, Choi H, Kim H, Jo D, Jeon Y, Noh J, et al. Neuronal vulnerability of CLN3 deletion to calcium-induced cytotoxicity is mediated by calsenilin. Hum Mol Genet. 2007;16:317-26 pubmed
    b>Calsenilin/DREAM/KChIP3, a neuronal Ca(2+)-binding protein, has multifunctions in nucleus and cytosol. Here, we identified CLN3 as a calsenilin-binding partner whose mutation or deletion is observed in Batten disease...
  66. Rivas M, Mellstrom B, Torres B, Cali G, Ferrara A, Terracciano D, et al. The DREAM protein is associated with thyroid enlargement and nodular development. Mol Endocrinol. 2009;23:862-70 pubmed publisher
    ..Here we show that DREAM (downstream regulatory element antagonist modulator) modulates TSHR activity through a direct protein-protein ..
  67. Holliday K, McBeth J, Macfarlane G, Huhtaniemi I, Bartfai G, Casanueva F, et al. Investigating the role of pain-modulating pathway genes in musculoskeletal pain. Eur J Pain. 2013;17:28-34 pubmed publisher
    The aim of this study was to determine if genetic variation in the pain-modulating gene DREAM and its pathway genes influence susceptibility to reporting musculoskeletal pain in the population...
  68. Grimm D, Grosse J, Wehland M, Mann V, Reseland J, Sundaresan A, et al. The impact of microgravity on bone in humans. Bone. 2016;87:44-56 pubmed publisher
    Experiencing real weightlessness in space is a dream for many of us who are interested in space research. Although space traveling fascinates us, it can cause both short-term and long-term health problems...
  69. Cavallotti S, Casetta C, Fanti V, Gambini O, Ostinelli E, Ranieri R, et al. Dream content and intrusive thoughts in Obsessive-Compulsive Disorder. Psychiatry Res. 2016;244:410-4 pubmed publisher
    Although central to any exhaustive theory of human subjectivity, the relationship between dream and waking consciousness remains uncertain...
  70. Zhang J, Li J, Craig T, Kumar R, Gross M. Hydrogen-Deuterium Exchange Mass Spectrometry Reveals Calcium Binding Properties and Allosteric Regulation of Downstream Regulatory Element Antagonist Modulator (DREAM). Biochemistry. 2017;56:3523-3530 pubmed publisher
    Downstream regulatory element antagonist modulator (DREAM) is an EF-hand Ca2+-binding protein that also binds to a specific DNA sequence, downstream regulatory elements (DRE), and thereby regulates transcription in a calcium-..
  71. Kim J, Hyun H, Min S, Lee D, Jeon A, Kim M, et al. PLPP/CIN Regulates Seizure Activity by the Differential Modulation of Calsenilin Binding to GluN1 and Kv4.2 in Mice. Front Mol Neurosci. 2017;10:303 pubmed publisher
    b>Calsenilin (CSEN) binds to Kv4.2 (an A-type K+ channel) as well as N-methyl-D-aspartate receptor (NMDAR), and modulates their activities. However, the regulatory mechanisms for CSEN-binding to Kv4...
  72. Gunn A, Laptook A, Robertson N, Barks J, Thoresen M, Wassink G, et al. Therapeutic hypothermia translates from ancient history in to practice. Pediatr Res. 2017;81:202-209 pubmed publisher
    ..The possibility that hypothermia may be able to prevent or lessen asphyxial brain injury is a "dream revisited"...
  73. Aggarwal R, Beer T, Gleave M, Stuart J, Rettig M, Evans C, et al. Targeting Adaptive Pathways in Metastatic Treatment-Resistant Prostate Cancer: Update on the Stand Up 2 Cancer/Prostate Cancer Foundation-Supported West Coast Prostate Cancer Dream Team. Eur Urol Focus. 2016;2:469-471 pubmed publisher
    The Stand Up 2 Cancer/Prostate Cancer Foundation-funded West Coast Dream Team project is a prospective multi-institutional study focused on acquiring metastatic castration-resistant prostate cancer (mCRPC) biopsy tissue at the time of ..
  74. van Zandwijk N, Pavlakis N, Kao S, Linton A, Boyer M, Clarke S, et al. Safety and activity of microRNA-loaded minicells in patients with recurrent malignant pleural mesothelioma: a first-in-man, phase 1, open-label, dose-escalation study. Lancet Oncol. 2017;18:1386-1396 pubmed publisher
    TargomiRs are minicells (EnGeneIC Dream Vectors) loaded with miR-16-based mimic microRNA (miRNA) and targeted to EGFR that are designed to counteract the loss of the miR-15 and miR-16 family miRNAs, which is associated with unsuppressed ..
  75. Iwahori S, Kalejta R. Phosphorylation of transcriptional regulators in the retinoblastoma protein pathway by UL97, the viral cyclin-dependent kinase encoded by human cytomegalovirus. Virology. 2017;512:95-103 pubmed publisher
    ..We observed that UL97 phosphorylates LIN52, a component of p107- and p130-assembled transcriptionally repressive DREAM complexes that control transcription during the G0/G1 phases, and the Rb-associated E2F3 protein that activates ..
  76. Andrews J, Bale J, Soep J, Long M, Carraccio C, Englander R, et al. Education in Pediatrics Across the Continuum (EPAC): First Steps Toward Realizing the Dream of Competency-Based Education. Acad Med. 2017;: pubmed publisher
  77. Lafrenière A, Lortie Lussier M, Dale A, Robidoux R, De Koninck J. Autobiographical memory sources of threats in dreams. Conscious Cogn. 2018;58:124-135 pubmed publisher
    Temporal sources of dream threats were examined through the paradigm of the Threat Simulation Theory...
  78. Zaidi N, Kuplast K, Washicosky K, Kajiwara Y, Buxbaum J, Wasco W. Calsenilin interacts with transcriptional co-repressor C-terminal binding protein(s). J Neurochem. 2006;98:1290-301 pubmed
    b>Calsenilin/potassium channel-interacting protein (KChIP)3/ downstream regulatory element sequence antagonist modulator (DREAM) is a neuronal calcium-binding protein that has been shown to have multiple functions in the cell, including the ..
  79. Benfari G, Rossi A, Geremia G, Vinco G, Zivelonghi C, Milano A, et al. Optimizing the role of transthoracic echocardiography to improve the cardiovascular risk stratification: the dream of subclinical coronary artery disease detection. Minerva Med. 2018;109:31-40 pubmed publisher
    ..Each parameter is presented with its strengths and weaknesses, aiming to trace the future directions for the development of a reliable non-invasive approach. ..
  80. Johnson B, Westlake K. Link Between Parkinson Disease and Rapid Eye Movement Sleep Behavior Disorder With Dream Enactment: Possible Implications for Early Rehabilitation. Arch Phys Med Rehabil. 2018;99:411-415 pubmed publisher
  81. Steinig J, Bazan A, Happe S, Antonetti S, Shevrin H. Processing of a Subliminal Rebus during Sleep: Idiosyncratic Primary versus Secondary Process Associations upon Awakening from REM- versus Non-REM-Sleep. Front Psychol. 2017;8:1955 pubmed publisher
    ..In a replication of the dream-rebus study of Shevrin and Fisher (1967), a rebus, which consisted of an image of a comb (German: "Kamm") and an ..
  82. Jo D, Lee J, Hong Y, Song S, Mook Jung I, Koh J, et al. Induction of pro-apoptotic calsenilin/DREAM/KChIP3 in Alzheimer's disease and cultured neurons after amyloid-beta exposure. J Neurochem. 2004;88:604-11 pubmed
    b>Calsenilin/DREAM/KChIP3 was identified as a calcium-binding protein that interacts with presenilins, serves as a transcription repressor, and binds to the A-type potassium channel...
  83. Jin J, Choi J, Wasco W, Buxbaum J, Kozlowski P, Carp R, et al. Expression of calsenilin in neurons and astrocytes in the Alzheimer's disease brain. Neuroreport. 2005;16:451-5 pubmed
    b>Calsenilin, a multifunctional Ca2+-binding protein, has been identified as an Alzheimer's disease-associated presenilin interactor...
  84. Raza K, Alam M. Recurrent neural network based hybrid model for reconstructing gene regulatory network. Comput Biol Chem. 2016;64:322-334 pubmed publisher
    ..tested on four benchmark networks such as DNA SOS repair network, IRMA network, and two synthetic networks from DREAM Challenge...
  85. Isidori A, Venneri M, Graziadio C, Simeoli C, Fiore D, Hasenmajer V, et al. Effect of once-daily, modified-release hydrocortisone versus standard glucocorticoid therapy on metabolism and innate immunity in patients with adrenal insufficiency (DREAM): a single-blind, randomised controlled trial. Lancet Diabetes Endocrinol. 2018;6:173-185 pubmed publisher
    ..Italian Ministry of University and Research. ..
  86. Zaidi N, Thomson E, Choi E, Buxbaum J, Wasco W. Intracellular calcium modulates the nuclear translocation of calsenilin. J Neurochem. 2004;89:593-601 pubmed
    b>Calsenilin, which was originally identified as a presenilin interacting protein, has since been shown to be involved in the processing of presenilin(s), the modulation of amyloid beta-peptide (Abeta) levels and apoptosis...
  87. Boichuk S, Parry J, Makielski K, Litovchick L, Baron J, Zewe J, et al. The DREAM complex mediates GIST cell quiescence and is a novel therapeutic target to enhance imatinib-induced apoptosis. Cancer Res. 2013;73:5120-9 pubmed publisher
    ..we provide evidence that imatinib induces GIST cell quiescence in vivo and that this process also involves the DREAM complex, a multisubunit complex that has recently been identified as an additional key regulator of quiescence...
  88. Powell J, Sweeting M, Ulug P, Blankensteijn J, Lederle F, Becquemin J, et al. Meta-analysis of individual-patient data from EVAR-1, DREAM, OVER and ACE trials comparing outcomes of endovascular or open repair for abdominal aortic aneurysm over 5 years. Br J Surg. 2017;104:166-178 pubmed publisher
    ..Trial registration numbers: EVAR-1, ISRCTN55703451; DREAM (Dutch Randomized Endovascular Aneurysm Management), NCT00421330; ACE (Anévrysme de l'aorte abdominale, ..
  89. De Luca A, Sidumo Z, Zanelli G, Magid N, Luhanga R, Brambilla D, et al. Accumulation of HIV-1 drug resistance in patients on a standard thymidine analogue-based first line antiretroviral therapy after virological failure: implications for the activity of next-line regimens from a longitudinal study in Mozambique. BMC Infect Dis. 2017;17:605 pubmed publisher
    ..We selected 48 patients from the DREAM cohort (Maputo, Mozambique); their median pre-ART CD4+ cell count was 165 cells/?l...
  90. Elhaik E, Yusuf L, Anderson A, Pirooznia M, Arnellos D, Vilshansky G, et al. The Diversity of REcent and Ancient huMan (DREAM): a new microarray for genetic anthropology and genealogy, forensics, and personalized medicine. Genome Biol Evol. 2017;: pubmed publisher
    ..We thereby aimed to design the Diversity of REcent and Ancient huMan (DREAM) - an all-inclusive microarray that would allow both identification of known associations and exploration of ..
  91. Veneroni L, Ferrari A, Proserpio T, Pagani Bagliacca E, Podda M, Massimino M, et al. Dreams and illusions in adolescents with terminal cancer. Tumori. 2017;: pubmed publisher
    ..Herein, we report the story of a 17-year-old girl with a metastatic refractory soft tissue sarcoma who tells her dream to the psychologist of the ward...
  92. Galetta K, Prasad S. Historical Trends in the Diagnosis of Peduncular Hallucinosis. J Neuroophthalmol. 2017;: pubmed publisher
    Peduncular hallucinosis (PH) describes the clinical syndrome of vivid, dream-like visual hallucinations that intrude on normal wakefulness...