KCNE1

Summary

Gene Symbol: KCNE1
Description: potassium voltage-gated channel, Isk-related family, member 1
Alias: ISK, JLNS, JLNS2, LQT2/5, LQT5, MinK, IKs producing slow voltage-gated potassium channel subunit beta Mink, cardiac delayed rectifier potassium channel protein, delayed rectifier potassium channel subunit IsK, minimal potassium channel, potassium voltage-gated channel subfamily E member 1, potassium voltage-gated channel, Isk-related subfamily, member 1, voltage gated potassiun channel accessory subunit
Species: human

Top Publications

  1. ncbi Separation and determination of glycosaminoglycan disaccharides by micellar electrokinetic capillary chromatography for studies of pelt glycosaminoglycans
    S Michaelsen
    Department of Research in Fur Animals, National Institute of Animal Science, Research Centre Foulum, Tjele, Denmark
    J Chromatogr A 652:503-15. 1993
  2. pmc Characterization of chimeric full-length molecular clones of Aleutian mink disease parvovirus (ADV): identification of a determinant governing replication of ADV in cell culture
    M E Bloom
    Laboratory of Persistent Viral Diseases, National Institute of Allergy and Infectious Diseases, Rocky Mountain Laboratories, Hamilton, Montana 59840
    J Virol 67:5976-88. 1993
  3. ncbi A novel mutation in the potassium channel gene KVLQT1 causes the Jervell and Lange-Nielsen cardioauditory syndrome
    N Neyroud
    INSERM UR153, Groupe Hospitalier Pitié Salpérrière, Institut de Myologie, Paris, France
    Nat Genet 15:186-9. 1997
  4. pmc Replication of Aleutian mink disease parvovirus in vivo is influenced by residues in the VP2 protein
    J M Fox
    Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, Hamilton, Montana 59840, USA
    J Virol 73:8713-9. 1999
  5. pmc Altered potassium balance and aldosterone secretion in a mouse model of human congenital long QT syndrome
    I Arrighi
    Institut de Pharmacologie Moleculaire et Cellulaire, Centre National de la Recherche Scientifique, 660, route des Lucioles, Sophia Antipolis, 06560 Valbonne, France
    Proc Natl Acad Sci U S A 98:8792-7. 2001
  6. ncbi Spectrum of mutations in long-QT syndrome genes. KVLQT1, HERG, SCN5A, KCNE1, and KCNE2
    I Splawski
    Department of Human Genetics, Howard Hughes Medical Institute, Division of Cardiology, Salt Lake City, Utah, USA
    Circulation 102:1178-85. 2000
  7. pmc Structure of KCNE1 and implications for how it modulates the KCNQ1 potassium channel
    Congbao Kang
    Department of Biochemitry, Vanderbilt University, Nashville, Tennessee 37232, USA
    Biochemistry 47:7999-8006. 2008
  8. ncbi Genetic variations of KCNQ1, KCNH2, SCN5A, KCNE1, and KCNE2 in drug-induced long QT syndrome patients
    Aimee D C Paulussen
    Department of Pharmacogenomics, Johnson and Johnson Pharmaceutical Research and Development, Turnhoutseweg 30, Beerse, Belgium
    J Mol Med (Berl) 82:182-8. 2004
  9. ncbi Four potassium channel mutations account for 73% of the genetic spectrum underlying long-QT syndrome (LQTS) and provide evidence for a strong founder effect in Finland
    Heidi Fodstad
    Research Program in Molecular Medicine, Biomedicum Helsinki, Finland
    Ann Med 36:53-63. 2004
  10. pmc KCNQ1 and KCNE1 in the IKs channel complex make state-dependent contacts in their extracellular domains
    Xulin Xu
    Department of Physiology and Biophysics, Medical College of Virginia, Virginia Commonwealth University, Richmond, VA 23298, USA
    J Gen Physiol 131:589-603. 2008

Detail Information

Publications166 found, 100 shown here

  1. ncbi Separation and determination of glycosaminoglycan disaccharides by micellar electrokinetic capillary chromatography for studies of pelt glycosaminoglycans
    S Michaelsen
    Department of Research in Fur Animals, National Institute of Animal Science, Research Centre Foulum, Tjele, Denmark
    J Chromatogr A 652:503-15. 1993
    ..Samples of chondroitin sulphates and mink skin were treated with proteases, and the extent of protein cleavage was followed by free zone capillary ..
  2. pmc Characterization of chimeric full-length molecular clones of Aleutian mink disease parvovirus (ADV): identification of a determinant governing replication of ADV in cell culture
    M E Bloom
    Laboratory of Persistent Viral Diseases, National Institute of Allergy and Infectious Diseases, Rocky Mountain Laboratories, Hamilton, Montana 59840
    J Virol 67:5976-88. 1993
    The ADV-G strain of Aleutian mink disease parvovirus (ADV) is nonpathogenic for mink but replicates permissively in cell culture, whereas the ADV-Utah 1 strain is highly pathogenic for mink but replicates poorly in cell culture...
  3. ncbi A novel mutation in the potassium channel gene KVLQT1 causes the Jervell and Lange-Nielsen cardioauditory syndrome
    N Neyroud
    INSERM UR153, Groupe Hospitalier Pitié Salpérrière, Institut de Myologie, Paris, France
    Nat Genet 15:186-9. 1997
    ..Taken together, our data indicate that KVLQT1 is responsible for both JLN and RW syndromes and has a key role not only in the ventricular repolarization but also in normal hearing, probably via the control of endolymph homeostasis...
  4. pmc Replication of Aleutian mink disease parvovirus in vivo is influenced by residues in the VP2 protein
    J M Fox
    Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, Hamilton, Montana 59840, USA
    J Virol 73:8713-9. 1999
    Aleutian mink disease parvovirus (ADV) is the etiological agent of Aleutian disease of mink. Several ADV isolates have been identified which vary in the severity of the disease they elicit...
  5. pmc Altered potassium balance and aldosterone secretion in a mouse model of human congenital long QT syndrome
    I Arrighi
    Institut de Pharmacologie Moleculaire et Cellulaire, Centre National de la Recherche Scientifique, 660, route des Lucioles, Sophia Antipolis, 06560 Valbonne, France
    Proc Natl Acad Sci U S A 98:8792-7. 2001
    ..responsible for the slowly activating delayed K(+) current I(Ks) is composed of pore-forming KCNQ1 and regulatory KCNE1 subunits, which are mutated in familial forms of cardiac long QT syndrome...
  6. ncbi Spectrum of mutations in long-QT syndrome genes. KVLQT1, HERG, SCN5A, KCNE1, and KCNE2
    I Splawski
    Department of Human Genetics, Howard Hughes Medical Institute, Division of Cardiology, Salt Lake City, Utah, USA
    Circulation 102:1178-85. 2000
    ..Five genes have been implicated in Romano-Ward syndrome, the autosomal dominant form of LQTS: KVLQT1, HERG, SCN5A, KCNE1, and KCNE2...
  7. pmc Structure of KCNE1 and implications for how it modulates the KCNQ1 potassium channel
    Congbao Kang
    Department of Biochemitry, Vanderbilt University, Nashville, Tennessee 37232, USA
    Biochemistry 47:7999-8006. 2008
    b>KCNE1 is a single-span membrane protein that modulates the voltage-gated potassium channel KCNQ1 (K V7...
  8. ncbi Genetic variations of KCNQ1, KCNH2, SCN5A, KCNE1, and KCNE2 in drug-induced long QT syndrome patients
    Aimee D C Paulussen
    Department of Pharmacogenomics, Johnson and Johnson Pharmaceutical Research and Development, Turnhoutseweg 30, Beerse, Belgium
    J Mol Med (Berl) 82:182-8. 2004
    ..Five cLQTS genes ( KCNH2, KCNQ1, SCN5A, KCNE1, KCNE2) were thoroughly screened for genetic variations in 32 drug-induced aLQTS patients with confirmed TdP and ..
  9. ncbi Four potassium channel mutations account for 73% of the genetic spectrum underlying long-QT syndrome (LQTS) and provide evidence for a strong founder effect in Finland
    Heidi Fodstad
    Research Program in Molecular Medicine, Biomedicum Helsinki, Finland
    Ann Med 36:53-63. 2004
    Mutations in five cardiac voltage-gated ion channel genes, including KCNQ1, HERG, SCN5A, KCNE1 and KCNE2, constitute the principal cause of inherited long-QT syndrome (LQTS)...
  10. pmc KCNQ1 and KCNE1 in the IKs channel complex make state-dependent contacts in their extracellular domains
    Xulin Xu
    Department of Physiology and Biophysics, Medical College of Virginia, Virginia Commonwealth University, Richmond, VA 23298, USA
    J Gen Physiol 131:589-603. 2008
    KCNQ1 and KCNE1 (Q1 and E1) associate to form the slow delayed rectifier I(Ks) channels in the heart...
  11. pmc Location of KCNE1 relative to KCNQ1 in the I(KS) potassium channel by disulfide cross-linking of substituted cysteines
    David Y Chung
    Department of Pharmacology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Proc Natl Acad Sci U S A 106:743-8. 2009
    ..is carried by a complex of KCNQ1 (Q1) subunits, containing the voltage-sensor domains and the pore, and auxiliary KCNE1 (E1) subunits, required for the characteristic I(KS) voltage dependence and kinetics...
  12. pmc Common candidate gene variants are associated with QT interval duration in the general population
    A Marjamaa
    Research Program in Molecular Medicine, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland
    J Intern Med 265:448-58. 2009
    ..As 30-40% of the QT-interval variability is heritable, we tested the association of common LQTS and NOS1AP gene variants with QT interval in a Finnish population-based sample...
  13. doi D85N, a KCNE1 polymorphism, is a disease-causing gene variant in long QT syndrome
    Yukiko Nishio
    Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan
    J Am Coll Cardiol 54:812-9. 2009
    This study aims to address whether D85N, a KCNE1 polymorphism, is a gene variant that causes long QT syndrome (LQTS) phenotype.
  14. ncbi Association of the human minK gene 38G allele with atrial fibrillation: evidence of possible genetic control on the pathogenesis of atrial fibrillation
    Ling Ping Lai
    Institute of Pharmacology, National Taiwan University, Taipei, Taiwan
    Am Heart J 144:485-90. 2002
    Human minK protein is the beta-subunit of I(Ks) potassium channel and plays an important role in cardiac cellular electrophysiology...
  15. ncbi Molecular cloning and sequence analysis of human genomic DNA encoding a novel membrane protein which exhibits a slowly activating potassium channel activity
    T Murai
    Institute for Immunology, Kyoto University, Faculty of Medicine, Japan
    Biochem Biophys Res Commun 161:176-81. 1989
    ....
  16. ncbi The single nucleotide polymorphisms of I(Ks) potassium channel genes and their association with atrial fibrillation in a Chinese population
    Zhiyu Zeng
    Center for Arrhythmia Diagnosis and Treatment, Cardiovascular Institute and Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
    Cardiology 108:97-103. 2007
    ..We investigated the association between AF and the single nucleotide polymorphisms (SNPs) of genes KCNQ1, KCNE1 and KCNE4 associated with this channel...
  17. pmc Intracellular domains interactions and gated motions of I(KS) potassium channel subunits
    Yoni Haitin
    Department of Physiology and Pharmacology, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 69978, Israel
    EMBO J 28:1994-2005. 2009
    ..In heart, assembly of Kv7.1 pore-forming subunits with KCNE1 beta subunits generates the repolarizing K(+) current I(KS)...
  18. ncbi Coassembly of K(V)LQT1 and minK (IsK) proteins to form cardiac I(Ks) potassium channel
    M C Sanguinetti
    Department of Medicine, Cardiology Division, University of Utah, Salt Lake City 84112, USA
    Nature 384:80-3. 1996
    ..of the I(Ks) channel is not known, but physiological data indicate that one component of the I(Ks), channel is minK, a 130-amino-acid protein with a single putative transmembrane domain...
  19. ncbi Requirement of a macromolecular signaling complex for beta adrenergic receptor modulation of the KCNQ1-KCNE1 potassium channel
    Steven O Marx
    Department of Pharmacology, Center for Molecular Cardiology, Department of Medicine, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA
    Science 295:496-9. 2002
    ..Yotiao binds to hKCNQ1 by a leucine zipper motif, which is disrupted by an LQTS mutation (hKCNQ1-G589D). Identification of the hKCNQ1 macromolecular complex provides a mechanism for SNS modulation of cardiac APD through IKS...
  20. pmc Common variants at ten loci influence QT interval duration in the QTGEN Study
    Christopher Newton-Cheh
    Center for Human Genetic Research, Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA
    Nat Genet 41:399-406. 2009
    ..We observed associations at P < 5 x 10(-8) with variants in NOS1AP, KCNQ1, KCNE1, KCNH2 and SCN5A, known to be involved in myocardial repolarization and mendelian long-QT syndromes...
  21. ncbi Characterization of the cardiac KCNE1 gene promoter
    Zenab Mustapha
    Research Center and Department of Medicine, Montreal Heart Institute and Universite de Montreal, Montreal, Quebec, Canada
    Cardiovasc Res 73:82-91. 2007
    b>KCNE1 encodes an essential cardiac slow delayed-rectifier potassium current (I(Ks)) beta-subunit (minK). Varying minK expression is important in disease-related remodeling and species-dependent expression...
  22. ncbi Association of KCNQ1, KCNE1, KCNH2 and SCN5A polymorphisms with QTc interval length in a healthy population
    Laetitia Gouas
    INSERM U582, Institut de Myologie, IFR 14, UPMC, Groupe Hospitalier Pitie Salpetriere, Paris, France
    Eur J Hum Genet 13:1213-22. 2005
    ..T (D1819D) minor alleles were significantly more frequent in the group with the shortest QTc interval, whereas KCNE1 253 A (D85N), SCN5A 1673 G (H558R) and 1141-3 A minor alleles were significantly more frequent in the group with ..
  23. pmc Stoichiometry of the KCNQ1 - KCNE1 ion channel complex
    Koichi Nakajo
    Division of Biophysics and Neurobiology, National Institute for Physiological Sciences, Okazaki, Aichi 444 8585, Japan
    Proc Natl Acad Sci U S A 107:18862-7. 2010
    The KCNQ1 voltage-gated potassium channel and its auxiliary subunit KCNE1 play a crucial role in the regulation of the heartbeat...
  24. pmc KCNE2 confers background current characteristics to the cardiac KCNQ1 potassium channel
    N Tinel
    Institut de Pharmacologie Moleculaire et Cellulaire, CNRS UPR 411, 660 route des Lucioles, Sophia Antipolis, 06560 Valbonne, France
    EMBO J 19:6326-30. 2000
    ..The KCNE family comprises at least three members. KCNE1 (IsK or MinK) recapitulates I(Ks) when associated with KCNQ1, whereas it augments the amplitude of an I(Kr)-like ..
  25. pmc KCNE peptides differently affect voltage sensor equilibrium and equilibration rates in KCNQ1 K+ channels
    Jessica M Rocheleau
    Department of Biochemistry and Molecular Pharmacology, University of Massachusetts, Worcester, MA 01605, USA
    J Gen Physiol 131:59-68. 2008
    ..KCNQ1/KCNE1 complexes generate the very slowly activating cardiac I(Ks) current, whereas assembly with KCNE3 produces a ..
  26. ncbi Possible association of the human KCNE1 (minK) gene and QT interval in healthy subjects: evidence from association and linkage analyses in Israeli families
    Y Friedlander
    Unit of Epidemiology, Hebrew University Hadassah School of Public Health, POB 12272, Jerusalem 91120, Israel
    Ann Hum Genet 69:645-56. 2005
    ..Using linkage and association analyses, we investigated whether variants in the potassium channel subunit KCNE1 are associated with QTc intervals in an unselected population sample of 80 kindreds living in kibbutz settlements ..
  27. ncbi Exclusion of KCNE1 (IsK) as a candidate gene for Jervell and Lange-Nielsen syndrome
    F Tesson
    INSERM UR153, Hopital Pitie Salpetriere, Institut de Myologie, Paris, France
    J Mol Cell Cardiol 28:2051-5. 1996
    The KCNE1 gene encodes a small protein, IsK, of 14.4 kDa, with a single transmembrane domain, and is part of a potassium channel expressed in the heart...
  28. ncbi The contribution of genes involved in potassium-recycling in the inner ear to noise-induced hearing loss
    Lut Van Laer
    Department of Medical Genetics, University of Antwerp, Antwerp, Belgium
    Hum Mutat 27:786-95. 2006
    ..susceptible and resistant individuals for the allele, genotype, and haplotype frequencies for three SNPs of the KCNE1 gene, and for the allele frequencies for one SNP of KCNQ1 and one SNP of KCNQ4...
  29. ncbi A minK-HERG complex regulates the cardiac potassium current I(Kr)
    T V McDonald
    Section of Molecular Cardiology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Nature 388:289-92. 1997
    b>MinK is a widely expressed protein of relative molecular mass approximately 15K that forms potassium channels by aggregation with other membrane proteins...
  30. ncbi Cellular dysfunction of LQT5-minK mutants: abnormalities of IKs, IKr and trafficking in long QT syndrome
    L Bianchi
    The Rammelkamp Center for Education and Research, MetroHealth Campus, Case Western Reserve University, 2500 MetroHealth Drive, Cleveland, OH 44109 1998, USA
    Hum Mol Genet 8:1499-507. 1999
    Mutations in the minK gene KCNE1 have been linked to the LQT5 variant of human long QT syndrome...
  31. pmc Interaction of KCNE subunits with the KCNQ1 K+ channel pore
    Gianina Panaghie
    Greenberg Division of Cardiology, Department of Medicine, Weill Medical College of Cornell University, 520 East 70th Street, New York, NY 10021, USA
    J Physiol 570:455-67. 2006
    KCNQ1 alpha subunits form functionally distinct potassium channels by coassembling with KCNE ancillary subunits MinK and MiRP2. MinK-KCNQ1 channels generate the slowly activating, voltage-dependent cardiac IKs current...
  32. ncbi IsK and KvLQT1: mutation in either of the two subunits of the slow component of the delayed rectifier potassium channel can cause Jervell and Lange-Nielsen syndrome
    J Tyson
    Unit of Clinical Genetics, Institute of Child Health and Great Ormond Street Hospital for Children NHS Trust, UCL Medical School, 30 Guilford Street, London WC1N 1EH, UK
    Hum Mol Genet 6:2179-85. 1997
    The Jervell and Lange-Nielsen syndrome (JLNS) comprises profound congenital sensorineural deafness associated with syncopal episodes...
  33. doi Effect of common KCNE1 and SCN5A ion channel gene variants on T-wave alternans, a marker of cardiac repolarization, during clinical exercise stress test: the Finnish Cardiovascular Study
    Jenni Koskela
    Department of Internal Medicine, Tampere University Hospital and Medical School at the University of Tampere, Tampere, Finland
    Transl Res 152:49-58. 2008
    ..We examined the effect of 3 ion channel gene single nucleotide polymorphisms (SNPs), rs1805127, rs727957 KCNE1, and rs1805124 SCN5A, on TWA during a clinical exercise test...
  34. ncbi Charybdotoxin binding in the I(Ks) pore demonstrates two MinK subunits in each channel complex
    Haijun Chen
    Department of Pediatrics, Boyer Center for Molecular Medicine, Yale University School of Medicine, 295 Congress Avenue, New Haven, CT 06536, USA
    Neuron 40:15-23. 2003
    I(Ks) voltage-gated K(+) channels contain four pore-forming KCNQ1 subunits and MinK accessory subunits in a number that has been controversial...
  35. ncbi Common variants in myocardial ion channel genes modify the QT interval in the general population: results from the KORA study
    Arne Pfeufer
    Institute of Human Genetics, Technical University Munich, Munich, Germany
    Circ Res 96:693-701. 2005
    ..Using a two-step design we analyzed 174 SNPs from the KCNQ1, KCNH2, KCNE1, and KCNE2 genes in 689 individuals from the population-based KORA study and 14 SNPs with results suggestive of ..
  36. ncbi Structural determinants of KvLQT1 control by the KCNE family of proteins
    Y F Melman
    Section of Molecular Cardiology, Department of Medicine, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Biol Chem 276:6439-44. 2001
    KvLQT1 is a Shaker-like voltage-gated potassium channel that when complexed with minK (KCNE1) produces the slowly activating delayed rectifier I(ks)...
  37. pmc Preparation, functional characterization, and NMR studies of human KCNE1, a voltage-gated potassium channel accessory subunit associated with deafness and long QT syndrome
    Changlin Tian
    Department of Biochemistry, Center for Structural Biology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 8725, USA
    Biochemistry 46:11459-72. 2007
    b>KCNE1, also known as minK, is a member of the KCNE family of membrane proteins that modulate the function of KCNQ1 and certain other voltage-gated potassium channels (KV)...
  38. ncbi A novel long-QT 5 gene mutation in the C-terminus (V109I) is associated with a mild phenotype
    E Schulze-Bahr
    Institute for Arteriosclerosis Research, University of Munster, Molecular Cardiology, Domagkstrasse 3, 48149 Munster, Germany
    J Mol Med (Berl) 79:504-9. 2001
    Mutations in the human minK gene KCNE1 have been linked to autosomal dominant and autosomal recessive long-QT (LQT) syndrome, a cardiac condition predisposing to ventricular arrhythmias...
  39. ncbi Expression of multiple KCNE genes in human heart may enable variable modulation of I(Ks)
    Andrew L Lundquist
    Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    J Mol Cell Cardiol 38:277-87. 2005
    ..In the human genome, KCNE proteins are encoded by five genes designated KCNE1 through KCNE5...
  40. ncbi N- and C-terminal KCNE1 mutations cause distinct phenotypes of long QT syndrome
    Seiko Ohno
    Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Heart Rhythm 4:332-40. 2007
    ..The MinK protein is a cardiac K-channel accessory subunit encoded by the KCNE1 gene, mutations of which are associated with the LQT5 form of LQTS.
  41. ncbi KCNE1 subunits require co-assembly with K+ channels for efficient trafficking and cell surface expression
    Kshama D Chandrasekhar
    Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    J Biol Chem 281:40015-23. 2006
    ..enzymatic deglycosylation, immunofluorescence, and quantitative cell surface labeling experiments, we show that KCNE1 peptides are retained in the early stages of the secretory pathway until they co-assemble with specific K(+) ..
  42. pmc Serial perturbation of MinK in IKs implies an alpha-helical transmembrane span traversing the channel corpus
    Haijun Chen
    The Department of Pediatrics and Institute for Molecular Pediatric Sciences, Pritzker School of Medicine, University of Chicago, Chicago, Illinois, USA
    Biophys J 93:2332-40. 2007
    I(Ks) channels contain four pore-forming KCNQ1 subunits and two accessory MinK subunits...
  43. ncbi Genetic testing in the long QT syndrome: development and validation of an efficient approach to genotyping in clinical practice
    Carlo Napolitano
    Molecular Cardiology, IRCCS Fondazione S Maugeri Foundation, Pavia, Italy
    JAMA 294:2975-80. 2005
    ..In long QT syndrome (LQTS), disease severity and response to therapy vary according to the genetic loci. There exists a critical need to devise strategies to expedite genetic analysis...
  44. ncbi Denaturing high-performance liquid chromatography screening of the long QT syndrome-related cardiac sodium and potassium channel genes and identification of novel mutations and single nucleotide polymorphisms
    Ling Ping Lai
    Institute of Pharmacology, National Taiwan University Hospital, Taipei, Taiwan
    J Hum Genet 50:490-6. 2005
    ..identified the mutation(s) in all four patients with congenital LQTS (KCNQ1 A341V, KCNH2 N633D, KCNH2 2768Cdel and KCNE1 K70 N Y81C double mutations)...
  45. ncbi Compendium of cardiac channel mutations in 541 consecutive unrelated patients referred for long QT syndrome genetic testing
    David J Tester
    Department of Internal Medicine, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Heart Rhythm 2:507-17. 2005
    ..The purpose of this study was to determine the spectrum and prevalence of cardiac channel mutations among a large cohort of consecutive, unrelated patients referred for long QT syndrome (LQTS) genetic testing...
  46. pmc Properties of KvLQT1 K+ channel mutations in Romano-Ward and Jervell and Lange-Nielsen inherited cardiac arrhythmias
    C Chouabe
    Institut de Pharmacologie Moleculaire et Cellulaire, CNRS, 660 route des Lucioles, Sophia Antipolis, 06560 Valbonne, France
    EMBO J 16:5472-9. 1997
    ..Expression studies revealed that the association of KvLQT1 with another subunit, IsK, reconstitutes a channel responsible for the IKs current involved in ventricular myocyte repolarization...
  47. ncbi The common non-synonymous variant G38S of the KCNE1-(minK)-gene is not associated to QT interval in Central European Caucasians: results from the KORA study
    Mahmut Akyol
    Institute of Human Genetics, GSF National Research Centre of Environment and Health, Ingolstadter Landstr 1, D 85764 Neuherberg, Germany
    Eur Heart J 28:305-9. 2007
    ..an association between QT interval and the common non-synonymous Glycin 38 Serine variant (G38S, rs1805127) of the KCNE1 gene coding for the minK-potassium channel subunit...
  48. ncbi Torsades de pointes complicating atrioventricular block: evidence for a genetic predisposition
    Philippe Chevalier
    Hopital Cardiologique, Hospices Civils de Lyon, Lyon, France
    Heart Rhythm 4:170-4. 2007
    ..The prevalence of genetic risk factors has not been systematically evaluated in the setting of complete atriventricular (AV) block complicated by long QT syndrome (LQTS)...
  49. pmc Functional interactions between KCNE1 C-terminus and the KCNQ1 channel
    Jerri Chen
    Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY, USA
    PLoS ONE 4:e5143. 2009
    The KCNE1 gene product (minK protein) associates with the cardiac KvLQT1 potassium channel (encoded by KCNQ1) to create the cardiac slowly activating delayed rectifier, I(Ks)...
  50. ncbi Expression and transcriptional control of human KCNE genes
    Andrew L Lundquist
    Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Genomics 87:119-28. 2006
    ..The KCNE genes (KCNE1-5) encode a family of single-transmembrane-domain proteins that modulate the properties of several potassium ..
  51. ncbi An LQT mutant minK alters KvLQT1 trafficking
    Andrew Krumerman
    Department of Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Am J Physiol Cell Physiol 286:C1453-63. 2004
    ..Mutations of genes encoding KvLQT1 and minK are responsible for the hereditary long QT syndrome (loci LQT1 and LQT5, respectively). MinK-L51H fails to traffic to the cell surface, thereby failing to produce effective I(Ks)...
  52. ncbi Compound mutations: a common cause of severe long-QT syndrome
    Peter Westenskow
    Department of Physiology, University of Utah, 95 South 2000 East, Salt Lake City, UT 84112 5000, USA
    Circulation 109:1834-41. 2004
    ..Although most LQTS individuals do not have cardiac events, significant phenotypic variability exists within families. Probands can be very symptomatic. The mechanism of this phenotypic variability is not understood...
  53. ncbi Mutation of the gene for IsK associated with both Jervell and Lange-Nielsen and Romano-Ward forms of Long-QT syndrome
    P Duggal
    Department of Cardiology, Children s Hospital, Harvard Medical School, Boston, Mass 02115, USA
    Circulation 97:142-6. 1998
    ..IsK, an apparent potassium channel subunit encoded by KCNE1 on chromosome 21, regulates both KVLQT1 and HERG...
  54. ncbi Mutations in the hminK gene cause long QT syndrome and suppress IKs function
    I Splawski
    Department of Human Genetics, University of Utah, Salt Lake City 84112, USA
    Nat Genet 17:338-40. 1997
    ..Recent physiological studies suggest that KCNE1 encodes beta-subunits (hminK) that co-assemble with KvLQT1 alpha-subunits to form the slowly activating delayed ..
  55. ncbi [Present concepts of congenital long QT syndrome]
    A Leenhardt
    Service de cardiologie, , Paris
    Arch Mal Coeur Vaiss 93:17-21. 2000
    ..the a subunit of the sodium channel INa (SCN5A for LQT3), and two regulatory subunits of potassium channels (KCNE1 for LQT5 regulating the KvLQT1 channel and MiRP1 regulating HERG)...
  56. pmc Gating and flickery block differentially affected by rubidium in homomeric KCNQ1 and heteromeric KCNQ1/KCNE1 potassium channels
    M Pusch
    Istituto di Cibernetica e Biofisica, Consiglio Nazionale della Ricerche, Via De Marini 6, I 16149 Genova, Italy
    Biophys J 78:211-26. 2000
    The voltage-gated potassium channel KCNQ1 associates with the small KCNE1 subunit to form the cardiac IKs delayed rectifier potassium current and mutations in both genes can lead to the long QT syndrome...
  57. pmc Ancillary subunits and stimulation frequency determine the potency of chromanol 293B block of the KCNQ1 potassium channel
    Glenna C L Bett
    Department of Gynecology and Obstetrics, Department of Physiology and Biophysics, 124 Sherman Hall, State University of NY at Buffalo, Buffalo, NY 14214, USA
    J Physiol 576:755-67. 2006
    ..In heart, KCNQ1 associates with KCNE1 (MinK), producing a slowly activating voltage-dependent channel...
  58. pmc The relationship between capsid protein (VP2) sequence and pathogenicity of Aleutian mink disease parvovirus (ADV): a possible role for raccoons in the transmission of ADV infections
    K L Oie
    Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, Hamilton, Montana 59840, USA
    J Virol 70:852-61. 1996
    Aleutian mink disease parvovirus (ADV) DNA was identified by PCR in samples from mink and raccoons on commercial ranches during an outbreak of Aleutian disease (AD)...
  59. ncbi Spontaneous mutation of cell oncogenes plays a minor role in neoplastic transformation of virus-induced murine T-cell lymphomas
    D Gasparotto
    Department of Experimental Oncology 1, Centro di Riferimento Oncologico, Aviano (PN, Italy
    Tumori 81:268-72. 1995
    b>Mink cell focus-forming viruses (MCF) are slow-transforming retroviruses that are able to accelerate the appearance of T-cell lymphomas when injected in newborn AKR mice...
  60. pmc Comparison of promoter activity in Aleutian mink disease parvovirus, minute virus of mice, and canine parvovirus: possible role of weak promoters in the pathogenesis of Aleutian mink disease parvovirus infection
    J Christensen
    Department of Veterinary Microbiology, Royal Veterinary and Agricultural University of Copenhagen, Frederiksberg, Denmark
    J Virol 67:1877-86. 1993
    Aleutian mink disease parvovirus (ADV) infection causes both acute and chronic disease in mink, and we have previously shown that it is the level of viral gene expression that determines the disease pattern...
  61. pmc Expression of Aleutian mink disease parvovirus capsid proteins in defined segments: localization of immunoreactive sites and neutralizing epitopes to specific regions
    M E Bloom
    Laboratory of Persistent Viral Diseases, National Institute of Allergy and Infectious Disease, Hamilton, Montana 59840, USA
    J Virol 71:705-14. 1997
    The capsid proteins of the ADV-G isolate of Aleutian mink disease parvovirus (ADV) were expressed in 10 nonoverlapping segments as fusions with maltose-binding protein in pMAL-C2 (pVP1, pVP2a through pVP2i)...
  62. pmc S-phase-dependent cell cycle disturbances caused by Aleutian mink disease parvovirus
    M B Oleksiewicz
    Department of Pharmacology and Pathobiology, Royal Veterinary and Agricultural University, Frederiksberg, Denmark
    J Virol 71:1386-96. 1997
    We examined replication of the autonomous parvovirus Aleutian mink disease parvovirus (ADV) in relation to cell cycle progression of permissive Crandell feline kidney (CRFK) cells...
  63. pmc Identification of a novel KCNQ1 mutation associated with both Jervell and Lange-Nielsen and Romano-Ward forms of long QT syndrome in a Chinese family
    Su Zhang
    Key Laboratory of Molecular Biophysics of Ministry of Education, College of Life Science and Technology, Center for Human Genome Research, Huazhong University of Science and Technology, Wuhan, PR China
    BMC Med Genet 9:24. 2008
    ..two inherited forms of LQTS have been defined: autosomal dominant LQTS or Romano-Ward syndrome (RWS) not associated with deafness and autosomal recessive LQTS or Jervell and Lange-Nielsen syndrome (JLNS) associated with deafness.
  64. ncbi Carnivora: the amino acid sequence of the adult European mink (Mustela lutreola, Mustelidae) hemoglobins
    A Ahmed
    , Abteilung Proteinchemie, , Bundersrepublik Deutschland
    Z Naturforsch C 45:223-8. 1990
    The complete amino acid sequences of the hemoglobins from the adult European mink (Mustela lutreola) are presented. The erythrocytes contain two hemoglobin components and three globin chains...
  65. ncbi Effect of dietary glycine and benzoate level on benzoate metabolism in mink (Mustela vision), blue fox (Alopex lagopus), and raccoon dog (Nyctereutes procyonoides)
    I J Pölönen
    Finnish Fur Breeders Association, Vantaa
    J Anim Sci 78:976-86. 2000
    Three 2 x 4 factorial experiments were carried out from August to September with 30 juvenile male mink, 24 raccoon dogs, and 24 blue foxes to investigate the effect of dietary glycine supply (low or high) on the efficiency of these ..
  66. pmc Aleutian mink disease parvovirus infection of mink peritoneal macrophages and human macrophage cell lines
    H Kanno
    Laboratory of Persistent Viral Diseases, National Institute of Allergy and Infectious Diseases, Rocky Mountain Laboratories, Hamilton, Montana 59840
    J Virol 67:2075-82. 1993
    Aleutian mink disease parvovirus (ADV) mRNAs are found in macrophages in lymph nodes and peritoneal exudate cells from ADV-infected mink...
  67. pmc Aleutian mink disease parvovirus infection of mink macrophages and human macrophage cell line U937: demonstration of antibody-dependent enhancement of infection
    H Kanno
    Laboratory of Persistent Viral Diseases, National Institute of Allergy and Infectious Diseases, Rocky Mountain Laboratories, Hamilton, Montana 59840
    J Virol 67:7017-24. 1993
    Aleutian mink disease parvovirus (ADV) infects macrophages in adult mink...
  68. ncbi Pathogenesis of disease caused by Aleutian mink disease parvovirus
    S Alexandersen
    Department of Veterinary Pathology, Royal Veterinary and Agricultural University, Copenhagen, Denmark
    APMIS Suppl 14:1-32. 1990
    A review of the pathogenesis of Aleutian mink disease parvovirus (ADV) infection based on recent knowledge gained by the author and collaborators is given. The review focuses mainly on the following topics...
  69. pmc Pathogenesis of Aleutian mink disease parvovirus infection: effects of suppression of antibody response on viral mRNA levels and on development of acute disease
    S Alexandersen
    Department of Pharmacology and Pathobiology, Royal Veterinary and Agricultural University of Copenhagen, Frederiksberg C, Denmark
    J Virol 68:738-49. 1994
    We suppressed the B-cell development and antibody response in mink by using treatment with polyclonal anti-immunoglobulin M (anti-IgM) to study the effects of antiviral antibodies on development of Aleutian mink disease parvovirus (ADV)-..
  70. pmc Replacement of interleukin-2 (IL-2)-generated mitogenic signals by a mink cell focus-forming (MCF) or xenotropic virus-induced IL-9-dependent autocrine loop: implications for MCF virus-induced leukemogenesis
    M M Flubacher
    Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111
    J Virol 68:7709-16. 1994
    ..IL-2)-dependent, Moloney murine leukemia virus (MoMuLV)-induced rat T-cell lymphoma line (4437A) with mink cell focus-forming (also called polytropic) murine retroviruses induces rapid progression to IL-2-independent ..
  71. ncbi Leptospirosis in free-ranging endangered European mink (Mustela lutreola) and other small carnivores (Mustelidae, Viverridae) from southwestern France
    Marie Moinet
    Groupe de Recherche et d Etude pour la Gestion de l Environnement, route de Préchac, 33730 Villandraut, France
    J Wildl Dis 46:1141-51. 2010
    To study the possible role of disease in the decline of endangered European mink (Mustela lutreola), we conducted a survey of antibody prevalence and renal carriage of pathogenic leptospira (Leptospira interrogans sensu lato) using serum ..
  72. ncbi Pathogenesis of aleutian mink disease parvovirus and similarities to b19 infection
    S M Best
    Laboratory of Persistent Viral Diseases, NIAID, NIH Rocky Mountain Laboratories, 903 S Fourth St, Hamilton, MT 59840, USA
    J Vet Med B Infect Dis Vet Public Health 52:331-4. 2005
    Aleutian mink disease parvovirus (ADV) is an unusual member of the autonomous parvoviruses in both its replication and pathogenesis...
  73. pmc cis-acting sequences in the Aleutian mink disease parvovirus late promoter important for transcription: comparison to the canine parvovirus and minute virus of mice
    T Storgaard
    Department of Pharmacology and Pathobiology, University of Copenhagen, Frederiksberg, Denmark
    J Virol 67:1887-95. 1993
    We are currently investigating the regulation of transcription of the Aleutian mink disease parvovirus (ADV)...
  74. pmc Mechanisms of ventricular arrhythmogenesis in mice following targeted disruption of KCNE1 modelling long QT syndrome 5
    Glyn Thomas
    Section of Cardiovascular Biology, Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge CB2 1QW, UK
    J Physiol 578:99-114. 2007
    Mutations within KCNE1 encoding a transmembrane protein which coassembles with K+ channels mediating slow K+, I(Ks), currents are implicated in cardiac action potential prolongation and ventricular arrhythmogenicity in long QT syndrome 5...
  75. ncbi Analysis of parvovirus infections using strand-specific hybridization probes
    M E Bloom
    Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, Hamilton, Montana
    Virus Res 14:1-25. 1989
    ..Strand-specific RNA hybridization probes were developed for the Aleutian mink disease parvovirus (ADV) and were used to study acute and chronic infections of mink...
  76. ncbi Comparisons of feline panleukopenia virus, canine parvovirus, raccoon parvovirus, and mink enteritis virus and their pathogenicity for mink and ferrets
    C R Parrish
    James A Baker Institute for Animal Health, New York State College of Veterinary Medicine, Cornell University, Ithaca 14853
    Am J Vet Res 48:1429-35. 1987
    Parvoviruses from mink (mink enteritis virus [MEV]), cats (feline panleukopenia virus [FPV]), raccoons (raccoon parvovirus [RPV]), and dogs (canine parvovirus [CPV]) were compared...
  77. pmc Duplication of U3 sequences in the long terminal repeat of mink cell focus-inducing viruses generates redundancies of transcription factor binding sites important for the induction of thymomas
    Nancy L DiFronzo
    Center for Virology and Immunology Research, Children s Research Institute, George Washington University School of Medical and Health Sciences, Washington, DC 20010, USA
    J Virol 77:3326-33. 2003
    The ability of mink cell focus-inducing (MCF) viruses to induce thymomas is determined, in part, by transcriptional enhancers in the U3 region of their long terminal repeats (LTRs)...
  78. pmc Radiographic evaluation of destructive periodontal disease in blue mink in relation to age and blood morphology
    Anne Sofie Hammer
    Danish Institute for Food and Veterinary Research, 2 Hangoevej, DK 8200 Aarhus, Denmark
    Can J Vet Res 69:128-34. 2005
    In this study, blood samples and jaws were collected from 2 genotypes of blue mink (n = 289) in order to examine phenotypic expression of specific characteristics of Chediak-Higashi Syndrome (C-HS)...
  79. pmc Two parvoviruses that cause different diseases in mink have different transcription patterns: transcription analysis of mink enteritis virus and Aleutian mink disease parvovirus in the same cell line
    T Storgaard
    Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, Hamilton, Montana 59840, USA
    J Virol 71:4990-6. 1997
    The two parvoviruses of mink cause very different diseases. Mink enteritis virus (MEV) is associated with rapid, high-level viral replication and acute disease...
  80. ncbi Effects of Aroclor 1242 and different fish-based diets on vitamins A1 (retinol) and A2 (3,4-didehydroretinol), and their fatty acyl esters in mink plasma
    Anne Käkelä
    Department of Biology, University of Joensuu, P O Box 111, FIN 80101 Joensuu, Finland
    Environ Res 91:104-12. 2003
    ..A(1)-18:1n-9; A(2)-18:1n-9 (oleates), and A(1)-18:0; A(2)-18:0 (stearates)) were studied in young female mink (Mustela vison) fed a diet based on freshwater smelt...
  81. pmc Cytokine profiles in adult mink infected with Aleutian mink disease parvovirus
    P V Jensen
    Laboratory of Virology and Immunology, Department of Veterinary Microbiology, The Royal Veterinary and Agricultural University, 1870 Frederiksberg C, Copenhagen, Denmark
    J Virol 77:7444-51. 2003
    ..interferon (IFN-gamma)-, interleukin 4 (IL-4)-, and IL-8-producing cells in peripheral blood mononuclear cells from mink infected with the Aleutian mink disease parvovirus (ADV)...
  82. pmc A novel mutation in KCNQ1 associated with a potent dominant negative effect as the basis for the LQT1 form of the long QT syndrome
    Yoshiyasu Aizawa
    Masonic Medical Research Laboratory, Utica, New York 13501 1787, USA
    J Cardiovasc Electrophysiol 18:972-7. 2007
    ..Long QT Syndrome (LQTS) is an inherited disorder characterized by prolonged QT intervals and life-threatening polymorphic ventricular tachyarrhythmias. LQT1 caused by KCNQ1 mutations is the most common form of LQTS...
  83. pmc Identification of a cell surface protein from Crandell feline kidney cells that specifically binds Aleutian mink disease parvovirus
    J M Fox
    Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana 59840, USA
    J Virol 73:3835-42. 1999
    Aleutian mink disease parvovirus (ADV) is the etiological agent of Aleutian disease of mink. The acute disease caused by ADV consists of permissive infection of alveolar type II cells that results in interstitial pneumonitis...
  84. ncbi Aleutian mink disease: puzzles and paradigms
    M E Bloom
    Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, Hamilton, Montana 59840
    Infect Agents Dis 3:279-301. 1994
    Aleutian mink disease (AD) is a naturally occurring persistent virus infection of mink caused by the Aleutian mink disease parvovirus (ADV)...
  85. pmc Passive transfer of antiviral antibodies restricts replication of Aleutian mink disease parvovirus in vivo
    S Alexandersen
    Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, Hamilton, Montana 59840
    J Virol 63:9-17. 1989
    When mink kits were infected neonatally with a highly virulent strain of Aleutian disease virus (ADV), 100% of both Aleutian and non-Aleutian genotype mink died of interstitial pneumonia characterized by permissive ADV infection of ..
  86. ncbi Vitamins A1 and A2 in hepatic tissue and subcellular fractions in mink feeding on fish-based diets and exposed to Aroclor 1242
    Anne Käkelä
    Department of Biology, University of Joensuu, Finland
    Environ Toxicol Chem 21:397-403. 2002
    Two-month-old female mink were fed diets based on either Baltic herring (Clupea harengus membras) or freshwater smelt (Osmerus eperlanus) for 21 weeks...
  87. ncbi Human beta(3)-adrenoreceptors couple to KvLQT1/MinK potassium channels in Xenopus oocytes via protein kinase C phosphorylation of the KvLQT1 protein
    Sven Kathofer
    Department of Cardiology, Medical University Hospital Heidelberg, Bergheimerstrasse 58, 69115, Heidelberg, Germany
    Naunyn Schmiedebergs Arch Pharmacol 368:119-26. 2003
    ..However, the signal transduction from the beta-adrenergic system to the KvLQT1/MinK (KCNQ1/KCNE1) potassium channel, which is the molecular correlate of the IKs current in human cardiomyocytes, is not ..
  88. ncbi Effects of ecotropic murine retroviruses on the dual-function cell surface receptor/basic amino acid transporter
    H Wang
    Department of Biochemistry and Molecular Biology, School of Medicine, Oregon Health Sciences University, Portland 97201 3098
    J Biol Chem 267:23617-24. 1992
    ..Accordingly, expression of mouse ecoR cDNA in mink CCL64 fibroblasts yields cells (CEN cells) that have y+ transporter activity above the endogenous background and ..
  89. ncbi Acute interstitial pneumonia in mink kits inoculated with defined isolates of Aleutian mink disease parvovirus
    S Alexandersen
    Laboratory of Molecular Pathobiology, Royal Veterinary and Agricultural University, Frederiksberg, Denmark
    Vet Pathol 31:216-28. 1994
    The present study addressed the causal role of Aleutian mink disease parvovirus (ADV) in acute interstitial pneumonia in mink kits...
  90. ncbi Assessment of effects in mink caused by consumption of carp collected from the Saginaw River, Michigan, USA
    S J Bursian
    Department of Animal Science, Michigan State University, East Lansing, 48824, USA
    Arch Environ Contam Toxicol 50:614-23. 2006
    ..Numerous studies have demonstrated mink (Mustela vison) to be one of the most sensitive species to this group of compounds...
  91. ncbi Cats differ from mink and ferrets in their response to commercial vaccines: a histologic comparison of early vaccine reactions
    E Eggers Carroll
    Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin Madison, 53706, USA
    Vet Pathol 39:216-27. 2002
    Early histologic changes in lesions at vaccine sites were compared in cats, mink, and ferrets...
  92. pmc Investigation of the pathogenesis of transplacental transmission of Aleutian mink disease parvovirus in experimentally infected mink
    S Broll
    Department of Pharmacology and Pathobiology, Royal Veterinary and Agricultural University of Copenhagen, Frederiksberg C, Denmark
    J Virol 70:1455-66. 1996
    The transplacental transmission of Aleutian mink disease parvovirus (ADV) was studied in experimental infection of 1-year-old female non-Aleutian mink...
  93. doi Arrhythmia phenotype in mouse models of human long QT
    Guy Salama
    Department of Cell Biology and Physiology, School of Medicine, University of Pittsburgh, S312 Biomedical Science Tower, 200 Lothrop St, Pittsburgh, PA 15261, USA
    J Interv Card Electrophysiol 24:77-87. 2009
    ..Here, we investigated the arrhythmia phenotype of mice with targeted deletions of KCNE1 and KCNH2 genes which encode for minK/IsK and Merg1 (mouse homolog of human ERG) proteins resulting in loss of ..
  94. ncbi Utilization of milk amino acids for body gain in suckling mink (Mustela vison) kits
    Anne Helene Tauson
    Department of Animal and Veterinary Basic Sciences, The Royal Veterinary and Agricultural University, Frederiksberg C, Denmark
    Arch Anim Nutr 59:99-109. 2005
    The efficiency of utilization of milk amino acids for body gain in suckling mink kits from small (n = 3), medium (n = 6) and large litters (n = 9) was investigated by using 36 mink dams and their litters for measurements during lactation ..
  95. ncbi Analyses of leucocytes in blood and lymphoid tissues from mink infected with Aleutian mink disease parvovirus (AMDV)
    W Chen
    Laboratory of Virology and Immunology, Department of Veterinary Microbiology, Royal Veterinary and Agricultural University, Copenhagen, Denmark
    Vet Immunol Immunopathol 63:317-34. 1998
    b>Mink were infected with Aleutian Mink Disease Parvovirus (AMDV) and sacrificed at monthly intervals after infection...
  96. doi Diversity and stability of Aleutian mink disease virus during bottleneck transitions resulting from eradication in domestic mink in Denmark
    L S Christensen
    National Food Institute, Technical University of Denmark, Mørkhøj Bygade 19, DK 2860 Søborg, Denmark
    Vet Microbiol 149:64-71. 2011
    Aleutian mink disease (plasmacytosis) virus (AMDV) in domestic mink (Neovison vison) has been subject to eradication in Denmark since 1976...
  97. ncbi LH release in mink (Mustela vison). Pattern of the LH surge and effect of metabolic status
    A H Tauson
    Department of Animal Science and Animal Health, The Royal Veterinary and Agricultural University, Frederiksberg C, Denmark
    Reprod Nutr Dev 40:229-47. 2000
    The mink is a seasonal breeder with induced ovulation and delayed implantation. Reproductive processes are strongly influenced by energy supply and body condition...
  98. ncbi The efficacy of mineral oil combined with feed restriction in enhancing the elimination of heptachlor epoxide from mink (Mustela vison)
    J A Crum
    Department of Animal Science, Michigan State University, East Lansing 48824
    Arch Environ Contam Toxicol 26:374-80. 1994
    Adult female mink previously fed diets containing 0 (control) and 6...
  99. ncbi Construction of pathogenic molecular clones of Aleutian mink disease parvovirus that replicate both in vivo and in vitro
    M E Bloom
    Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, Hamilton, Montana, 59840, USA
    Virology 251:288-96. 1998
    The ADV-G isolate of Aleutian mink disease parvovirus (ADV) replicates permissively in Crandell feline kidney (CRFK) cells but is nonpathogenic for mink, whereas the highly pathogenic ADV-Utah isolate is nonviable in CRFK cells...
  100. pmc Immunohistochemical detection of 3 viral infections in paraffin-embedded tissue from mink (Mustela vison): a tissue-microarray-based study
    Anne Sofie Hammer
    Department of Poultry, Fish and Fur Animals, Danish Institute for Food and Veterinary Research, 2 Hangoevej, DK 8200 Aarhus, Denmark
    Can J Vet Res 71:8-13. 2007
    ..IHC) assays were developed and tested for the detection of 3 viral infections in archived paraffin-embedded mink tissue...
  101. ncbi Neuropathologic features of Aleutian disease in farmed mink in Ireland and molecular characterization of Aleutian mink disease virus detected in brain tissues
    Hanne Jahns
    Veterinary Sciences Section, School of Agriculture, Food Science and Veterinary Medicine, Veterinary Sciences Centre, R 010 University College Dublin, Belfield, Dublin 14, Ireland
    J Vet Diagn Invest 22:101-5. 2010
    A neuropathologic survey was conducted on mink brains from the 5 licensed mink farms in Ireland. The survey was part of a transmissible spongiform encephalopathy surveillance study...

Research Grants75

  1. Structural Analysis of Voltage-gated Potassium Channels
    ROBERT BLAUSTEIN; Fiscal Year: 2006
    ..Shaker channel, and heteromultimeric channels formed from the co-assembly of Shaker-like subunits with minK-related peptides (MiRPs)...
  2. MOLECULAR DETERMINANTS OF POTASSIUM CHANNEL DRUG BLOCK
    Dirk Snyders; Fiscal Year: 2003
    ..molecular architecture of the channel protein complex includes function-altering accessory subunits (beta subunits, minK) which may impact on drug binding...
  3. MinK-related peptides(MiRPs): structure and function
    Steve Goldstein; Fiscal Year: 2004
    DESCRIPTION: MinK is a small ion channel subunit with a single transmembrane span. It is active only after assembly with a pore-forming subunit. Nonetheless, MinK is required for normal channel function in some tissues...
  4. Role of KVS and MPS Subunits in Basic Neuronal Function
    Federico Sesti; Fiscal Year: 2007
    ..elegans nervous system. In addition we cloned raps-l, the first C. elegans MiRP. MinK Related Peptides (MiRPs) are small transmembrane proteins that associate with K + channels to alter their function...
  5. Role of KVS and MPS Subunits in Basic Neuronal Function
    Federico Sesti; Fiscal Year: 2007
    ..elegans nervous system. In addition we cloned mps-1, the first C. elegans MiRP. MinK Related Peptides (MiRPs) are small transmembrane proteins that associate with K+ channels to alter their function...
  6. Modulation of cardiac K+ channels by drugs
    Michael Sanguinetti; Fiscal Year: 2004
    ..the genes that encode the alpha- and beta-subunits that co assemble to form Ikr (HERG and MiRPl or IKs (KvLQT1 and minK) channels cause inherited long QT syndrome and sudden death...
  7. K+ channel trafficking and modulation in MinK and MiRP1
    GEOFFREY ABBOTT; Fiscal Year: 2009
    ..Preliminary data show that single transmembrane domain, Kv channel ancillary subunits called MiRPs (MinK-Related Peptides) can act not just as biophysical modulators of Kv channels, but also as molecular chaperones that ..
  8. K+ channel trafficking and modulation in MinK and MiRP1
    GEOFFREY ABBOTT; Fiscal Year: 2009
    ..Preliminary data show that single transmembrane domain, Kv channel ancillary subunits called MiRPs (MinK-Related Peptides) can act not just as biophysical modulators of Kv channels, but also as molecular chaperones that ..
  9. TARGETING HERG: A MOUSE MODEL OF THE LONG QT SYNDROME
    Barry London; Fiscal Year: 2002
    ..HERG subunits interact in-vitro with IsK (minK), a K+ channel beta-subunit that coassembles with KvLQT1 to form the cardiac current IKs...
  10. TRANSCRIPTIONAL CONTROL OF MAMMALIAN BRAIN DEVELOPMENT
    Eseng Lai; Fiscal Year: 2001
    ..hypothesis that BF-1 regulates cell cycle and thus controls number of neurons in telencephalon and as assayed in Mink cell culture system...
  11. DETERMINANTS OF CARDIAC REPOLARIZATION
    Craig January; Fiscal Year: 2004
    ..of some LQT-2 mutants to function normally involves defects in multiple processing steps, b) co-expression of the minK or minK-related subunits modifies HERG wild type and LQT-2 protein trafficking, c) co-expression of wild type HERG ..
  12. Long QT Syndrome: Population, Genetic & Cardiac Studies
    Arthur Moss; Fiscal Year: 2006
    ..Presently, over 300 mutations on 6 ion-channel genes (KCNQ1, HERG, SCNhA, minK, MIRP1, and KCNJ2) have been identified in LQTS...
  13. MOLECULAR PHARMACOLOGY OF AN INHERITED HEART DISEASE
    Robert Kass; Fiscal Year: 2001
    ..that encode the heart sodium channel alpha-subunit (SCN5A), and the slow potassium channel current (IKs) KvLQT-1/or minK cause identifiable changes in expressed sodium and potassium channel activity that underlie diseased-associated ..
  14. Mechanism of Prion Neurotropism
    Surachai Supattapone; Fiscal Year: 2010
    ..bovine spongiform encephalopathy (BSE) in cattle, chronic wasting disease (CWD) in deer and elk, transmissible mink encephalopathy (TME) in mink, and scrapie in sheep...
  15. Structural Basis for KCNE Modulation of the KCNQ1 Channel
    Carlos G Vanoye; Fiscal Year: 2010
    The human KCNQ1 voltage-gated potassium channel is modulated by interactions with an accessory subunit, KCNE1, a process that is essential for healthy cardiac and auditory function...
  16. Neonatal Long QT Syndrome and Sudden Infant Death
    ALFRED GEORGE; Fiscal Year: 2007
    ..The complete coding regions and splice site sequences of KCNQ1, KCNH2, SCN5A, KCNE1, KCNE2 and coding exons of other candidate genes will be surveyed for variants in four populations, two large SIDS ..
  17. Neonatal Long QT Syndrome and Sudden Infant Death
    Alfred L George; Fiscal Year: 2010
    ..The complete coding regions and splice site sequences of KCNQ1, KCNH2, SCN5A, KCNE1, KCNE2 and coding exons of other candidate genes will be surveyed for variants in four populations, two large SIDS ..
  18. Neonatal Long QT Syndrome and Sudden Infant Death
    ALFRED GEORGE; Fiscal Year: 2009
    ..The complete coding regions and splice site sequences of KCNQ1, KCNH2, SCN5A, KCNE1, KCNE2 and coding exons of other candidate genes will be surveyed for variants in four populations, two large SIDS ..
  19. MULTI-ANALYTE WAVEGUIDE IMMUNOSENSING
    JAMES HERRON; Fiscal Year: 2002
    ..LQTS has been linked to genetic polymorphisms in four genes (KVLQT1,HERG, SCN5A & KCNE1) that encode for cardiac ion channels...
  20. Molecular Physiology of KCNE Potassium Channel Subunits
    ALFRED GEORGE; Fiscal Year: 2007
    ..In the human genome, KCNE proteins are encoded by five genes designated KCNE1 through KCNE5...