Gene Symbol: KCNA5
Description: potassium voltage-gated channel subfamily A member 5
Alias: ATFB7, HCK1, HK2, HPCN1, KV1.5, PCN1, potassium voltage-gated channel subfamily A member 5, cardiac potassium channel, insulinoma and islet potassium channel, potassium channel 1, potassium channel, voltage gated shaker related subfamily A, member 5, potassium voltage-gated channel, shaker-related subfamily, member 5, voltage-gated potassium channel HK2, voltage-gated potassium channel protein Kv1.5, voltage-gated potassium channel subunit Kv1.5
Species: human
Products:     KCNA5

Top Publications

  1. Decher N, Pirard B, Bundis F, Peukert S, Baringhaus K, Busch A, et al. Molecular basis for Kv1.5 channel block: conservation of drug binding sites among voltage-gated K+ channels. J Biol Chem. 2004;279:394-400 pubmed
    ..Based on the homology models, the positions of the five amino acids identified to interact with S0100176 face toward the central cavity and overlap with putative binding sites for other blockers and voltage-gated potassium channels. ..
  2. Labro A, Raes A, Snyders D. Coupling of voltage sensing to channel opening reflects intrasubunit interactions in kv channels. J Gen Physiol. 2005;125:71-80 pubmed
    ..With each mutation in a separate subunit of a tandem, this compensation did not occur. This suggests that for Kv channels, the coupling between voltage sensing and gating reflects primarily an intrasubunit interaction. ..
  3. Yang T, Yang P, Roden D, Darbar D. Novel KCNA5 mutation implicates tyrosine kinase signaling in human atrial fibrillation. Heart Rhythm. 2010;7:1246-52 pubmed publisher
    ..Loss-of-function mutations in KCNA5 encoding the ultrarapid delayed rectifier potassium current I(Kur) have been identified in AF families...
  4. Tamkun M, Knoth K, Walbridge J, Kroemer H, Roden D, Glover D. Molecular cloning and characterization of two voltage-gated K+ channel cDNAs from human ventricle. FASEB J. 1991;5:331-7 pubmed
    ..These two cDNAs, designated HK1 and HK2, encode proteins of 653 and 605 amino acids, respectively...
  5. Kurata H, Soon G, Eldstrom J, Lu G, Steele D, Fedida D. Amino-terminal determinants of U-type inactivation of voltage-gated K+ channels. J Biol Chem. 2002;277:29045-53 pubmed
    ..1. These data suggest that intersubunit T1 domain interactions influence U-type inactivation in Kv1 channels, and suggest a generalized influence of the T1 domain on U-type inactivation between Kv channel subfamilies. ..
  6. Brevnova E, Platoshyn O, Zhang S, Yuan J. Overexpression of human KCNA5 increases IK V and enhances apoptosis. Am J Physiol Cell Physiol. 2004;287:C715-22 pubmed
    ..The objective of this study was to test the hypothesis that overexpression of KCNA5, which encodes a delayed-rectifier voltage-gated K+ (Kv) channel, increases K+ currents and enhances apoptosis...
  7. Remillard C, Tigno D, Platoshyn O, Burg E, Brevnova E, Conger D, et al. Function of Kv1.5 channels and genetic variations of KCNA5 in patients with idiopathic pulmonary arterial hypertension. Am J Physiol Cell Physiol. 2007;292:C1837-53 pubmed
    ..Here, we report that overexpression of the Kv1.5 channel gene (KCNA5) in human PASMC and other cell lines produced a 15-pS single channel current and a large whole cell current that ..
  8. Vicente R, Villalonga N, Calvo M, Escalada A, Solsona C, Soler C, et al. Kv1.5 association modifies Kv1.3 traffic and membrane localization. J Biol Chem. 2008;283:8756-64 pubmed publisher
    ..3 and Kv1.5 targeting to rafts. Our results implicate the traffic and localization of Kv1.3/Kv1.5 heteromers in the complex regulation of immune system cells. ..
  9. Yang Z, Browning C, Hallaq H, Yermalitskaya L, Esker J, Hall M, et al. Four and a half LIM protein 1: a partner for KCNA5 in human atrium. Cardiovasc Res. 2008;78:449-57 pubmed publisher
    ..In human heart, the Shaker-related voltage-gated K(+) channel KCNA5 alpha-subunit forms the major basis of an atrial-specific, ultra-rapid delayed rectifier K(+) current, I(Kur)...

More Information

Publications124 found, 100 shown here

  1. Schumacher S, McEwen D, Zhang L, Arendt K, Van Genderen K, Martens J. Antiarrhythmic drug-induced internalization of the atrial-specific k+ channel kv1.5. Circ Res. 2009;104:1390-8 pubmed publisher
  2. Burg E, Platoshyn O, Tsigelny I, Lozano Ruiz B, Rana B, Yuan J. Tetramerization domain mutations in KCNA5 affect channel kinetics and cause abnormal trafficking patterns. Am J Physiol Cell Physiol. 2010;298:C496-509 pubmed publisher
    ..We recently reported two nonsynonymous mutations (G182R and E211D) in the KCNA5 gene of patients with idiopathic pulmonary arterial hypertension, which localize to the T1 domain of KCNA5...
  3. Archer S, Gomberg Maitland M, Maitland M, Rich S, Garcia J, Weir E. Mitochondrial metabolism, redox signaling, and fusion: a mitochondria-ROS-HIF-1alpha-Kv1.5 O2-sensing pathway at the intersection of pulmonary hypertension and cancer. Am J Physiol Heart Circ Physiol. 2008;294:H570-8 pubmed
    ..Mitochondrial abnormalities that disturb the ROS-HIF-1alpha-Kv1.5 O(2)-sensing pathway contribute to the pathogenesis of PAH and cancer and constitute promising therapeutic targets. ..
  4. Abi Char J, El Haou S, Balse E, Neyroud N, Vranckx R, Coulombe A, et al. The anchoring protein SAP97 retains Kv1.5 channels in the plasma membrane of cardiac myocytes. Am J Physiol Heart Circ Physiol. 2008;294:H1851-61 pubmed publisher
    ..In conclusion, SAP97 regulates the K(+) current in cardiac myocytes by retaining and immobilizing Kv1.5 subunits in the plasma membrane. This new regulatory mechanism may contribute to the targeting of Kv channels in cardiac myocytes. ..
  5. Yang Y, Li J, Lin X, Yang Y, Hong K, Wang L, et al. Novel KCNA5 loss-of-function mutations responsible for atrial fibrillation. J Hum Genet. 2009;54:277-83 pubmed publisher
    ..However, the molecular defects in most patients with AF remain to be identified. Here, we report on three novel KCNA5 mutations that were identified in 4 of 120 unrelated AF families...
  6. Wipff J, Dieude P, Guedj M, Ruiz B, Riemekasten G, Cracowski J, et al. Association of a KCNA5 gene polymorphism with systemic sclerosis-associated pulmonary arterial hypertension in the European Caucasian population. Arthritis Rheum. 2010;62:3093-100 pubmed publisher
    ..genes have also been advocated, including potassium voltage-gated channel, shaker-related subfamily, member 5 (KCNA5)...
  7. Christophersen I, Olesen M, Liang B, Andersen M, Larsen A, Nielsen J, et al. Genetic variation in KCNA5: impact on the atrial-specific potassium current IKur in patients with lone atrial fibrillation. Eur Heart J. 2013;34:1517-25 pubmed publisher
    Genetic factors may be important in the development of atrial fibrillation (AF) in the young. KCNA5 encodes the potassium channel ?-subunit KV1.5, which underlies the voltage-gated atrial-specific potassium current IKur...
  8. Labro A, Raes A, Bellens I, Ottschytsch N, Snyders D. Gating of shaker-type channels requires the flexibility of S6 caused by prolines. J Biol Chem. 2003;278:50724-31 pubmed
    ..These results indicate that the destabilization or bending of the S6 alpha-helix caused by the PXP motif apparently creates a flexible "hinge" that allows movement of the lower S6 segment during channel gating and opening. ..
  9. Hwang S, Song J, Kim Y, Lim J, Kim M, Kim E, et al. Inhibition of lymphatic proliferation by the selective VEGFR-3 inhibitor SAR131675 ameliorates diabetic nephropathy in db/db mice. Cell Death Dis. 2019;10:219 pubmed publisher
    ..In addition, we studied palmitate-induced lymphangiogenesis in human kidney-2 (HK2) cells and RAW264.7 monocytes/macrophages, which play a major role in lymphangiogenesis in the kidneys...
  10. Li Z, Hong Z, Peng Z, Zhao Y, Shao R. Acetylshikonin from Zicao ameliorates renal dysfunction and fibrosis in diabetic mice by inhibiting TGF-?1/Smad pathway. Hum Cell. 2018;31:199-209 pubmed publisher
    ..acetylshikonin markedly attenuated TGF-?1-induced the PAI-1, collagen III and IV, and Smad-2/3 phosphorylation in HK2 immortalized human proximal tubule epithelial cells...
  11. Tyszka Czochara M, Bukowska Strakova K, Kocemba Pilarczyk K, Majka M. Caffeic Acid Targets AMPK Signaling and Regulates Tricarboxylic Acid Cycle Anaplerosis while Metformin Downregulates HIF-1α-Induced Glycolytic Enzymes in Human Cervical Squamous Cell Carcinoma Lines. Nutrients. 2018;10: pubmed publisher
    ..as glucose transporters (GLUT1, GLUT3) and regulatory enzymes of glycolytic pathway Hexokinase 2 (HK2), 6-Phosphofructo-2-Kinase/Fructose-2,6-Biphosphatase 4 (PFKFB4), Pyruvate Kinase (PKM) and ..
  12. Massari F, Ciccarese C, Santoni M, Iacovelli R, Mazzucchelli R, Piva F, et al. Metabolic phenotype of bladder cancer. Cancer Treat Rev. 2016;45:46-57 pubmed publisher
    ..genes (SRC-3, glucose transporter type 1 [GLUT1], GLUT3, lactic dehydrogenase A [LDHA], LDHB, hexokinase 1 [HK1], HK2, pyruvate kinase type M [PKM], and hypoxia-inducible factor 1-alpha [HIF-1α]), resulting in an overproduction of ..
  13. Sen Z, Weida W, Jie M, Li S, Dongming Z, Xiaoguang C. Coumarin glycosides from Hydrangea paniculata slow down the progression of diabetic nephropathy by targeting Nrf2 anti-oxidation and smad2/3-mediated profibrosis. Phytomedicine. 2018;57:385-395 pubmed publisher
    ..2)-like 2 (Nrf2) and IL6 and western blot was performed to analyse the phosphorylation status of smad 2/3 in HK2 cells under TGFβ1 stimulation...
  14. Choe M, Brusgard J, Chumsri S, Bhandary L, Zhao X, Lu S, et al. The RUNX2 Transcription Factor Negatively Regulates SIRT6 Expression to Alter Glucose Metabolism in Breast Cancer Cells. J Cell Biochem. 2015;116:2210-26 pubmed publisher
    ..RUNX2 knockdown resulted in lower LDHA, HK2, and GLUT1 glycolytic gene expression, but upregulation of pyruvate dehydrogenase-A1 (PDHA1) mRNA and enzymatic ..
  15. Schutt A, Blesson C, Hsu J, Valdes C, Gibbons W, Jahoor F, et al. Preovulatory exposure to a protein-restricted diet disrupts amino acid kinetics and alters mitochondrial structure and function in the rat oocyte and is partially rescued by folic acid. Reprod Biol Endocrinol. 2019;17:12 pubmed publisher
    ..05) and Hk2 (p < 0...
  16. Nahan K, Walsh K, Adeoye O, Landero Figueroa J. The metal and metalloprotein profile of human plasma as biomarkers for stroke diagnosis. J Trace Elem Med Biol. 2017;42:81-91 pubmed publisher
    ..Stroke-related metalloproteins were identified, including calpain-15, protein-activated inward rectifier potassium channel 1, tau-tubulin kinase 1, and voltage-dependent L-type calcium channel subunit beta-3...
  17. Xu X, Li D, Li X, Shi Q, Ju X. Mesenchymal stem cell conditioned medium alleviates oxidative stress injury induced by hydrogen peroxide via regulating miR143 and its target protein in hepatocytes. BMC Immunol. 2017;18:51 pubmed publisher
    ..cell conditioned medium (MSC-CM) and explore the roles of the beta-1 adrenergic receptor (ADRB1) and hexokinase 2 (HK2) in this process...
  18. Shahzad M, Small D, Morais C, Wojcikowski K, Shabbir A, Gobe G. Protection against oxidative stress-induced apoptosis in kidney epithelium by Angelica and Astragalus. J Ethnopharmacol. 2016;179:412-9 pubmed publisher
    ..membranaceus and A. sinensis were prepared by a three-solvent sequential process. HK2 human kidney proximal tubular epithelial cells were treated with H2O2 alone (0...
  19. Rodriguez S, Rudloff S, Koenig K, Karthik S, Hoogewijs D, Huynh Do U. Bidirectional signalling between EphA2 and ephrinA1 increases tubular cell attachment, laminin secretion and modulates erythropoietin expression after renal hypoxic injury. Pflugers Arch. 2016;468:1433-48 pubmed publisher
    ..Stimulation of EphA2 forward signalling in the proximal tubular cell line HK2 increased cell attachment and laminin secretion at the baso-lateral side...
  20. Palmieri D, Fitzgerald D, Shreeve S, Hua E, Bronder J, Weil R, et al. Analyses of resected human brain metastases of breast cancer reveal the association between up-regulation of hexokinase 2 and poor prognosis. Mol Cancer Res. 2009;7:1438-45 pubmed publisher
    ..Hexokinase 2 (HK2) was also of interest because of its increased expression in brain metastases...
  21. Li C, Lin Y, Luo R, Chen S, Wang F, Zheng P, et al. Intrarenal renin-angiotensin system mediates fatty acid-induced ER stress in the kidney. Am J Physiol Renal Physiol. 2016;310:F351-63 pubmed publisher
    ..saturated fatty acid-induced endoplasmic reticulum (ER) stress in cultured human proximal tubule epithelial cells (HK2) and in mice fed with a high-fat diet. Treatment with saturated fatty acid palmitic acid (PA; 0...
  22. Archer S. Acquired Mitochondrial Abnormalities, Including Epigenetic Inhibition of Superoxide Dismutase 2, in Pulmonary Hypertension and Cancer: Therapeutic Implications. Adv Exp Med Biol. 2016;903:29-53 pubmed publisher
    ..In conclusion, cancer and PAH share acquired mitochondrial abnormalities that increase proliferation and inhibit apoptosis, suggesting new therapeutic targets. ..
  23. Harfmann B, Schroder E, Kachman M, Hodge B, Zhang X, Esser K. Muscle-specific loss of Bmal1 leads to disrupted tissue glucose metabolism and systemic glucose homeostasis. Skelet Muscle. 2016;6:12 pubmed publisher
    ..We also found that both mRNA expression and activity of two key rate-limiting enzymes of glycolysis, hexokinase 2 (Hk2) and phosphofructokinase 1 (Pfk1), were significantly reduced in the iMSBmal1 (-/-) muscle...
  24. Xiao W, Sarsour E, Wagner B, Doskey C, Buettner G, Domann F, et al. Succinate dehydrogenase activity regulates PCB3-quinone-induced metabolic oxidative stress and toxicity in HaCaT human keratinocytes. Arch Toxicol. 2016;90:319-32 pubmed publisher
    ..Results from a q-RT-PCR assay showed significant increases in the mRNA levels of hexokinase 2 (hk2), pyruvate kinase M2 (pkm2) and glucose-6-phosphate dehydrogenase (g6pd), and decreases in the mRNA levels of ..
  25. Amrutkar M, Cansby E, Chursa U, Nuñez Durán E, Chanclón B, Ståhlman M, et al. Genetic Disruption of Protein Kinase STK25 Ameliorates Metabolic Defects in a Diet-Induced Type 2 Diabetes Model. Diabetes. 2015;64:2791-804 pubmed publisher
    ..controlling the muscle oxidative capacity (Cpt1, Acox1, Cs, Cycs, Ucp3) and glucose metabolism (Glut1, Glut4, Hk2) was increased...
  26. Broecker Preuss M, Becher Boveleth N, Bockisch A, Duhrsen U, Muller S. Regulation of glucose uptake in lymphoma cell lines by c-MYC- and PI3K-dependent signaling pathways and impact of glycolytic pathways on cell viability. J Transl Med. 2017;15:158 pubmed publisher
    ..Expression of mRNAs of the glucose transporter 1 (GLUT1), hexokinase 2 (HK2), glucose-6-phosphatase (G6Pase) and lactate dehydrogenase A (LDHA) and of the glucose metabolism-regulating micro ..
  27. Wang Q, Gao H, Liang Y, Zhang J, Wang J, Qiu J. Cofilin1 is involved in hypertension-induced renal damage via the regulation of NF-κB in renal tubular epithelial cells. J Transl Med. 2015;13:323 pubmed publisher
    ..phosphorylation of cofilin1, the formation of actin stress fibres and nuclear translocation of NF-κB p65 in the HK2 cells...
  28. Zhou Q, Ning Y, Zeng R, Chen L, Kou P, Xu C, et al. Erbin interacts with Sema4C and inhibits Sema4C-induced epithelial-mesenchymal transition in HK2 cells. J Huazhong Univ Sci Technolog Med Sci. 2013;33:672-679 pubmed publisher
    ..Here, we aimed to examine the interaction between Erbin and Sema4C. HK2 cells were treated with TGF-?1, or transfected with Erbin and (or) Sema4C...
  29. Krasnov G, Dmitriev A, Sadtritdinova A, Fedorova M, Snezhkina A, Melnikova N, et al. [Evaluation of Gene Expression of Hexokinases in Colorectal Cancer with the Use of Bioinformatics Methods]. Biofizika. 2015;60:1050-6 pubmed
    ..The glycolysis activation can be caused by overexpression of hexokinases, primarily HK1 and HK2. Colorectal cancer, which takes the third place in the cancer morbidity and mortality rates worldwide, is believed ..
  30. Nishijima Y, Cao S, Chabowski D, Korishettar A, Ge A, Zheng X, et al. Contribution of KV1.5 Channel to Hydrogen Peroxide-Induced Human Arteriolar Dilation and Its Modulation by Coronary Artery Disease. Circ Res. 2017;120:658-669 pubmed publisher
    ..Loss of KV1.5 vasomotor function may play an important role in microvascular dysfunction in CAD or other vascular diseases. ..
  31. Winther S, Isidor M, Basse A, Skjoldborg N, Cheung A, Quistorff B, et al. Restricting glycolysis impairs brown adipocyte glucose and oxygen consumption. Am J Physiol Endocrinol Metab. 2017;:ajpendo.00218.2017 pubmed publisher
    ..Diminishing glycolytic flux by knockdown of the first and final enzyme of glycolysis, i.e. hexokinase 2 (HK2) and pyruvate kinase M (PKM), respectively, decreased glucose uptake and ISO-stimulated oxygen consumption...
  32. Vysotskaya Z, Chidipi B, Rodgers J, Tang X, Samal E, Kolliputi N, et al. Elevated potassium outward currents in hyperoxia treated atrial cardiomyocytes. J Cell Physiol. 2017;: pubmed publisher
    ..The data presented here further support our previous findings that hyperoxia induces not only ventricular remodeling, but also atrial electrical remodeling. This article is protected by copyright. All rights reserved...
  33. Vilhelmsson Timmermand O, Larsson E, Ulmert D, Tran T, Strand S. Radioimmunotherapy of prostate cancer targeting human kallikrein-related peptidase 2. EJNMMI Res. 2016;6:27 pubmed publisher
    ..we investigated the uptake and therapeutic efficacy of (177)Lu-m11B6, a human kallikrein-related peptidase 2 (hK2)-targeting radioimmunoconjugate in a pre-clinical setting...
  34. Nishitani A, Tanaka M, Shimizu S, Kunisawa N, Yokoe M, Yoshida Y, et al. Involvement of aspartoacylase in tremor expression in rats. Exp Anim. 2016;65:293-301 pubmed publisher
    ..emerge when two mutant loci, a missense mutation in the hyperpolarization-activated cyclic nucleotide-gated potassium channel 1 (Hcn1) and the tremor (tm) deletion, are present simultaneously...
  35. Maiti A, Islam M, Satou R, Majid D. Enhancement in cellular Na+K+ATPase activity by low doses of peroxynitrite in mouse renal tissue and in cultured HK2 cells. Physiol Rep. 2016;4: pubmed publisher
  36. Jiao L, Zhang H, Li D, Yang K, Tang J, Li X, et al. Regulation of glycolytic metabolism by autophagy in liver cancer involves selective autophagic degradation of HK2 (hexokinase 2). Autophagy. 2018;14:671-684 pubmed publisher
    ..The autophagic degradation of HK2 (hexokinase 2), a crucial glycolytic enzyme catalyzing the conversion of glucose to glucose-6-phosphate, was found ..
  37. Zhang Y, Ao X, Li H, Deng S, Xiao Z, Peng W, et al. [Cordyceps sinensis protects HK2 cells from ischemia-reperfusion injury through Sirt1 pathway]. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2017;42:1263-1269 pubmed publisher
    To investigate the effects of Cordyceps sinensis (CS) on cellular apoptosis and Sirt1 expression in HK2 cells followed by ischemia-reperfusion (I/R)...
  38. McKay M, Worley J. Linoleic acid both enhances activation and blocks Kv1.5 and Kv2.1 channels by two separate mechanisms. Am J Physiol Cell Physiol. 2001;281:C1277-84 pubmed
    ..Additionally, the methyl ester of LA was effective at enhancing peak current and promoting channel activation for Kv1.5 and Kv2.1 without inducing significant current inhibition...
  39. David M, Macías A, Moreno C, Prieto A, Martínez Mármol R, Vicente R, et al. Protein kinase C (PKC) activity regulates functional effects of Kv?1.3 subunit on KV1.5 channels: identification of a cardiac Kv1.5 channelosome. J Biol Chem. 2012;287:21416-28 pubmed publisher
    ..5, K(v)?1.3, the receptor for activated C kinase (RACK1), PKC?I, PKC?II, and PKC? in HEK293 cells. A very similar K(v)1.5 channelosome was found in rat ventricular tissue but not in atrial tissue. ..
  40. Lan H, Luo L, Qi X, Gong Y, Chen Y. [miR-181c inhibits glycolysis by targeting hexokinase 2 in cancer-associated fibroblasts]. Nan Fang Yi Ke Da Xue Xue Bao. 2015;35:1619-23 pubmed
    ..primary culture of tissue explants, were transfected with a miR -181c mimics, a miR-181c inhibitor, a siRNA siRNA-HK2 or the vector HK2-vector via Lipofectamine(TM) 2000...
  41. Thorek D, Watson P, Lee S, Ku A, Bournazos S, Braun K, et al. Internalization of secreted antigen-targeted antibodies by the neonatal Fc receptor for precision imaging of the androgen receptor axis. Sci Transl Med. 2016;8:367ra167 pubmed
    ..AR-regulated human kallikrein-related peptidase 2 (free hK2) is a prostate tissue-specific antigen produced in prostate cancer and androgen-stimulated breast cancer cells...
  42. Chiyoda T, Hart P, Eckert M, McGregor S, Lastra R, Hamamoto R, et al. Loss of BRCA1 in the Cells of Origin of Ovarian Cancer Induces Glycolysis: A Window of Opportunity for Ovarian Cancer Chemoprevention. Cancer Prev Res (Phila). 2017;10:255-266 pubmed publisher
    ..carrying deleterious BRCA1 mutations (5382insC or the P1749R), there was an increase in hexokinase-2 (HK2), a key glycolytic enzyme. This effect was mediated by MYC and the STAT3...
  43. Viticchiè G, Agostini M, Lena A, Mancini M, Zhou H, Zolla L, et al. p63 supports aerobic respiration through hexokinase II. Proc Natl Acad Sci U S A. 2015;112:11577-82 pubmed publisher
    ..The glycolytic enzyme hexokinase 2 (HK2) represents the first step of glucose utilization in cells...
  44. Li L, Yang Y, Chen H, Zhang L, Pan D, Xie W. MicroRNA-181b inhibits glycolysis in gastric cancer cells via targeting hexokinase 2 gene. Cancer Biomark. 2016;17:75-81 pubmed publisher
    ..At the molecular level, miR-181b directly inhibits the expression level of hexokinase 2 (HK2), a key enzyme that catalyzes the first step of glycolysis, through targeting its 3'-untranslated region...
  45. Cheng W, Ji S, Zhang H, Han Z, Liu Q, Wang J, et al. mTOR activation is critical for betulin treatment in renal cell carcinoma cells. Biochem Biophys Res Commun. 2017;482:1030-1036 pubmed publisher
    ..In addition, betulin significantly inhibited the expression of PKM2 and HK2 in 786-O cells...
  46. Convento M, Pessoa E, Cruz E, da Glória M, Schor N, Borges F. Calcium oxalate crystals and oxalate induce an epithelial-to-mesenchymal transition in the proximal tubular epithelial cells: Contribution to oxalate kidney injury. Sci Rep. 2017;7:45740 pubmed publisher
    ..and kidney fibrosis in mice and if oxalate or calcium oxalate (CaOx) could induce EMT in proximal tubule cells (HK2) and therefore contribute to the fibrotic process...
  47. Mao J, Li W, Mi B, Dawuda M, CALDERON URREA A, Ma Z, et al. Different exogenous sugars affect the hormone signal pathway and sugar metabolism in "Red Globe" (Vitis vinifera L.) plantlets grown in vitro as shown by transcriptomic analysis. Planta. 2017;246:537-552 pubmed publisher
    ..depended on the balanced expression of key potential candidate genes related to hormones (TCP15, LOG3, IPT3, ETR1, HK2, HK3, CKX7, SPY, GH3s, MYBH, AGB1, MKK2, PP2C, PYL, ABF, SnRK, etc...
  48. Vallée A, Lecarpentier Y, Guillevin R, Vallée J. Aerobic Glycolysis Hypothesis Through WNT/Beta-Catenin Pathway in Exudative Age-Related Macular Degeneration. J Mol Neurosci. 2017;62:368-379 pubmed publisher
    ..Increased WNT/beta-catenin pathway involves hexokinase 2 (HK2) and pyruvate kinase M2 (PKM2)...
  49. Fernandes F, Oliveira A, Landgraf T, Cunha C, Carvalho A, Vendruscolo P, et al. Impact of Paracoccin Gene Silencing on Paracoccidioides brasiliensis Virulence. MBio. 2017;8: pubmed publisher
    ..brasiliensis yeast strains (AsPCN1, AsPCN2, and AsPCN3) and characterized them with regard to P...
  50. Liang P, Zhu W, Lan T, Tao Q. Detection of salivary protein biomarkers of saliva secretion disorder in a primary Sjögren syndrome murine model. J Pharm Biomed Anal. 2018;154:252-262 pubmed publisher
    ..IHC and IPA indicated that CTNNA3 may regulate acinar cell morphology, while PTPN6 and RAC2 promoted lymphocyte adhesion in salivary glands. Thus, CTNNA3, PTPN6, and RAC2 may be related to saliva secretion disorder in pSS. ..
  51. Kidd M, Leo M, Bannister J, Jaggar J. Intravascular pressure enhances the abundance of functional Kv1.5 channels at the surface of arterial smooth muscle cells. Sci Signal. 2015;8:ra83 pubmed publisher
    ..Thus, our data indicate that intravascular pressure-induced membrane depolarization selectively increased K(v)1.5 surface abundance to increase K(v) currents in arterial myocytes, which would limit vasoconstriction. ..
  52. Baschnagel A, Wobb J, Dilworth J, Williams L, Eskandari M, Wu D, et al. The association of (18)F-FDG PET and glucose metabolism biomarkers GLUT1 and HK2 in p16 positive and negative head and neck squamous cell carcinomas. Radiother Oncol. 2015;117:118-24 pubmed publisher
    To investigate the relationship between FDG-PET maximum standard uptake value (SUVmax), p16, EGFR, GLUT1 and HK2 expression in head and neck squamous cell carcinomas (HNSCC)...
  53. Geng C, Li J, Ding F, Wu G, Yang Q, Sun Y, et al. Curcumin suppresses 4-hydroxytamoxifen resistance in breast cancer cells by targeting SLUG/Hexokinase 2 pathway. Biochem Biophys Res Commun. 2016;473:147-153 pubmed publisher
    ..Further investigation showed that SLUG activated the transcription of hexokinase-2 (HK2) by binding to HK2 promoter...
  54. Heiss E, Schachner D, Donati M, Grojer C, Dirsch V. Increased aerobic glycolysis is important for the motility of activated VSMC and inhibited by indirubin-3'-monoxime. Vascul Pharmacol. 2016;83:47-56 pubmed publisher
    ..recognized as inhibitor of VSMC migration, was able to counteract the PDGF-activated increase in glycolysis and HK2 abundance...
  55. Minchenko D, Novik Y, Maslak H, Tiazhka O, Minchenko O. [EXPRESSION OF PFKFB, HK2, NAMPT, TSPAN13 AND HSPB8 GENES IN PEDIATRIC GLIOMA]. Lik Sprava. 2015;:43-8 pubmed
    ..isolated from glioma tissue and corresponding non-malignant tissue counterparts and PFKFB1, PFKFB2, PFKFB3, PFKFB4, HK2, NAMPT, TSPAN13, and HSPB8 gene expressions were studied by quantitative polymerase chain reaction...
  56. Zhao Y, Yin Z, Li H, Fan J, Yang S, Chen C, et al. MiR-30c protects diabetic nephropathy by suppressing epithelial-to-mesenchymal transition in db/db mice. Aging Cell. 2017;16:387-400 pubmed publisher
    ..this study, loss of miR-30c accompanied with increased EMT was observed in renal tubules of db/db mice and cultured HK2 cells exposed to high glucose...
  57. Saleem M, Pokkunuri I, Asghar M. Superoxide increases angiotensin II AT1 receptor function in human kidney-2 cells. FEBS Open Bio. 2016;6:1273-1284 pubmed publisher
    ..and the specific role of Sp3 transcription factor, if any, in the regulation of AT1R in human kidney cells (HK2 cells)...
  58. Han Y, Shi Y, Han Z, Sun L, Fan D. Detection of potassium currents and regulation of multidrug resistance by potassium channels in human gastric cancer cells. Cell Biol Int. 2007;31:741-7 pubmed
    ..5 enhanced the drug-resistant phenotype of SGC7901 cells. In conclusion, potassium channels may exert regulatory effects on multidrug resistance by regulating drug-induced apoptosis in gastric cancer cells. ..
  59. Koutsouki E, Lam R, Seebohm G, Ureche O, Ureche L, Baltaev R, et al. Modulation of human Kv1.5 channel kinetics by N-cadherin. Biochem Biophys Res Commun. 2007;363:18-23 pubmed
    ..In conclusion, N-cadherin modifies Kv1.5 channel activity and is thus a novel candidate signaling molecule participating in the regulation of a variety of functions including cardiac action potential and vascular tone. ..
  60. Crump S, Hu Z, Kant R, Levy D, Goldstein S, Abbott G. Kcne4 deletion sex- and age-specifically impairs cardiac repolarization in mice. FASEB J. 2016;30:360-9 pubmed publisher
    ..01) to match noncastrated levels. KCNE4 is thereby shown to be a DHT-regulated determinant of cardiac excitability and a molecular substrate for sex- and age-dependent cardiac arrhythmogenesis. ..
  61. Wu W, Sanguinetti M. Molecular Basis of Cardiac Delayed Rectifier Potassium Channel Function and Pharmacology. Card Electrophysiol Clin. 2016;8:275-84 pubmed publisher
    ..Most blockers bind to S6 residues that line the central cavity of the channel, whereas activators interact with the channel at 4 symmetric binding sites outside the cavity. ..
  62. Wang H, Wang H, Wang C, Chen Y, Ma R, Xiang J, et al. Inhibitory effects of hesperetin on Kv1.5 potassium channels stably expressed in HEK 293 cells and ultra-rapid delayed rectifier K(+) current in human atrial myocytes. Eur J Pharmacol. 2016;789:98-108 pubmed publisher
    ..5 currents in HEK 293 cells. In conclusion, hesperetin is a potent inhibitor of Ikur (which is encoded by Kv1.5), with blockade probably due to blocking of both open state and inactivated state channels from outside of the cell. ..
  63. Gu Z, Xia J, Xu H, Frech I, Tricot G, Zhan F. NEK2 Promotes Aerobic Glycolysis in Multiple Myeloma Through Regulating Splicing of Pyruvate Kinase. J Hematol Oncol. 2017;10:17 pubmed publisher
    ..Knockdown of NEK2 decreases the ratio of PKM2/PKM1 and also other aerobic glycolysis genes including GLUT4, HK2, ENO1, LDHA, and MCT4...
  64. Zhang S, Kurata H, Kehl S, Fedida D. Rapid induction of P/C-type inactivation is the mechanism for acid-induced K+ current inhibition. J Gen Physiol. 2003;121:215-25 pubmed
    ..4, led us to favor the hypothesis that a reduction in the activation energy for the inactivation transition from the open state underlies the inhibition of hKv1.5 Na(+) current at low pH. ..
  65. Zadeh A, Xu H, Loewen M, Noble G, Steele D, Fedida D. Internalized Kv1.5 traffics via Rab-dependent pathways. J Physiol. 2008;586:4793-813 pubmed publisher
    ..The Rab GTPases thus constitute dynamic targets by which cells may modulate Kv1.5 functional expression. ..
  66. Bai J, Ding W, Kojima A, Seto T, Matsuura H. Putative binding sites for arachidonic acid on the human cardiac Kv 1.5 channel. Br J Pharmacol. 2015;172:5281-92 pubmed publisher
    ..AA itself interacts with multiple amino acids located in the pore domain of the hKv 1.5 channel. These findings may provide useful information for future development of selective blockers of hKv 1.5 channels. ..
  67. Huang C, Lin M, Cheng D, Braet F, Pollock C, Chen X. KCa3.1 mediates dysfunction of tubular autophagy in diabetic kidneys via PI3k/Akt/mTOR signaling pathways. Sci Rep. 2016;6:23884 pubmed publisher
    ..1 in dysfunctional tubular autophagy in diabetic nephropathy, human proximal tubular cells (HK2) transfected with scrambled or KCa3...
  68. Penny H, Sieow J, Adriani G, Yeap W, See Chi Ee P, San Luis B, et al. Warburg metabolism in tumor-conditioned macrophages promotes metastasis in human pancreatic ductal adenocarcinoma. Oncoimmunology. 2016;5:e1191731 pubmed publisher
    ..Inhibiting glycolysis in TAMs with a competitive inhibitor to Hexokinase II (HK2), 2-deoxyglucose (2DG), was sufficient to disrupt this pro-metastatic phenotype, reversing the observed increases ..
  69. Lewinska A, Adamczyk Grochala J, Kwasniewicz E, Deregowska A, Wnuk M. Ursolic acid-mediated changes in glycolytic pathway promote cytotoxic autophagy and apoptosis in phenotypically different breast cancer cells. Apoptosis. 2017;22:800-815 pubmed publisher
    ..UA (20 µM) also diminished AKT signaling that affected glycolysis as judged by decreased levels of HK2, PKM2, ATP and lactate. UA-induced energy stress activated AMPK that resulted in cytotoxic autophagy and apoptosis...
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    Blockage of some ion channels and in particular, the hERG (human Ether-a'-go-go-Related Gene) cardiac potassium channel delays cardiac repolarization and can induce arrhythmia...
  71. Peretz A, Gil Henn H, Sobko A, Shinder V, Attali B, Elson A. Hypomyelination and increased activity of voltage-gated K(+) channels in mice lacking protein tyrosine phosphatase epsilon. EMBO J. 2000;19:4036-45 pubmed
    ..In all, PTP epsilon antagonizes activation of Kv channels by tyrosine kinases in vivo, and affects Schwann cell function during a critical period of Schwann cell growth and myelination. ..
  72. Philipson L, Hice R, Schaefer K, LaMendola J, Bell G, Nelson D, et al. Sequence and functional expression in Xenopus oocytes of a human insulinoma and islet potassium channel. Proc Natl Acad Sci U S A. 1991;88:53-7 pubmed
    ..This K+ channel isoform, designated hPCN1, with a deduced amino acid sequence of 613 residues (Mr = 67,097), is related to the Shaker family of Drosophila K+..
  73. Wu J, Chen Z, Liu Q, Zeng W, Wu X, Lin B. Silencing of Kv1.5 Gene Inhibits Proliferation and Induces Apoptosis of Osteosarcoma Cells. Int J Mol Sci. 2015;16:26914-26 pubmed publisher
    Kv1.5 (also known as KCNA5) is a protein encoded by the KCNA5 gene, which belongs to the voltage-gated potassium channel, shaker-related subfamily. Recently, a number of studies have suggested that Kv1...
  74. Guerrico A, Hillman D, Karnes J, Davis B, Gaston S, Klee G. Roles of kallikrein-2 biomarkers (free-hK2 and pro-hK2) for predicting prostate cancer progression-free survival. J Circ Biomark. 2017;6:1849454417720151 pubmed publisher
    Free human kallikrein 2 (free-hK2) and hK2 pro-form (pro-hK2) have been found to be increased in tumor tissues and serum from patients with prostate cancer...
  75. Zhang X, Zhang M, Cong Q, Zhang M, Zhang M, Lu Y, et al. Hexokinase 2 confers resistance to cisplatin in ovarian cancer cells by enhancing cisplatin-induced autophagy. Int J Biochem Cell Biol. 2018;95:9-16 pubmed publisher
    ..Hexokinase 2 (HK2) phosphorylates glucose to generate glucose-6-phosphate, the rate-limiting step in glycolysis...
  76. Williams C, Hu N, Shen W, Mashburn A, Murray K. Modulation of the human Kv1.5 channel by protein kinase C activation: role of the Kvbeta1.2 subunit. J Pharmacol Exp Ther. 2002;302:545-50 pubmed
    ..5 to PKC activation and that direct phosphorylation of K(+) channel subunits is a potential molecular basis for the effect. Furthermore, they suggest that Kvbeta1.2 may be a component of the I(Kur) complex in human atrium. ..
  77. Kim S, Ao Z, Warnock G, McIntosh C. Incretin-stimulated interaction between ?-cell Kv1.5 and Kv?2 channel proteins involves acetylation/deacetylation by CBP/SirT1. Biochem J. 2013;451:227-34 pubmed publisher
    ..5 in response to GIP or GLP-1. Incretin regulation of ?-cell function therefore involves the acetylation of multiple Kv? and Kv? subunits. ..
  78. Ruben J, García Romo G, Breman E, van der Kooij S, Redeker A, Arens R, et al. Human plasmacytoid dendritic cells acquire phagocytic capacity by TLR9 ligation in the presence of soluble factors produced by renal epithelial cells. Kidney Int. 2018;93:355-364 pubmed publisher
    ..Maturation and interferon alpha production by pDCs was enhanced when cells were activated in the presence of viable HK2 renal epithelial cells...
  79. Park S, Lee Y, Ma T, Park J, Han M, Lee H, et al. hKv1.5 channels play a pivotal role in the functions of human alveolar macrophages. Biochem Biophys Res Commun. 2006;346:567-71 pubmed
    ..5 channel was lowered by the antisense hKv1.5 oligodeoxynucleotides. These results suggest that hKv1.5 channel is expressed in human alveolar macrophages and it plays a role in phagocytosis and migration of the human alveolar macrophage. ..
  80. Hayashi K, Konno T, Tada H, Tani S, Liu L, Fujino N, et al. Functional Characterization of Rare Variants Implicated in Susceptibility to Lone Atrial Fibrillation. Circ Arrhythm Electrophysiol. 2015;8:1095-104 pubmed publisher
    ..We identified 7 rare variants in KCNA5, KCNQ1, KCNH2, SCN5A, and SCN1B genes in 8 patients: 2 of 8 probands had a family history of AF...
  81. Gupta P, Sheikh T, Sen E. SIRT6 regulated nucleosomal occupancy affects Hexokinase 2 expression. Exp Cell Res. 2017;357:98-106 pubmed publisher
    ..association between inflammation and dysregulated metabolism in glioblastoma, the effect of IL-1? on Hexokinase 2 (HK2) expression was investigated. IL-1? induced HK2 expression was accompanied by heightened SIRT6 and MZF1 levels...
  82. Overturf K, Russell S, Carl A, Vogalis F, Hart P, Hume J, et al. Cloning and characterization of a Kv1.5 delayed rectifier K+ channel from vascular and visceral smooth muscles. Am J Physiol. 1994;267:C1231-8 pubmed
    ..5 in smooth muscles of the gastrointestinal tract and abundant expression in several vascular smooth muscles. We propose that cKv1.5 represents a component of the delayed rectifier current in both vascular and visceral smooth muscles...
  83. Kuryshev Y, Wible B, Gudz T, Ramirez A, Brown A. KChAP/Kvbeta1.2 interactions and their effects on cardiac Kv channel expression. Am J Physiol Cell Physiol. 2001;281:C290-9 pubmed
    ..2 may alter both sustained and transient cardiac Kv currents. The interaction of these two different classes of modulatory proteins may constitute a novel mechanism for regulating cardiac K+ currents...
  84. Mia S, Munoz C, Pakladok T, Siraskar G, Voelkl J, Alesutan I, et al. Downregulation of Kv1.5 K channels by the AMP-activated protein kinase. Cell Physiol Biochem. 2012;30:1039-50 pubmed publisher
    ..5-mediated currents. AMPK is a potent regulator of Kv1.5. AMPK inhibits Kv1.5 presumably in part by activation of Nedd4- 2 with subsequent clearance of channel protein from the cell membrane. ..
  85. Yokoyama N, Miller W. Biochemical properties of the Cdc42-associated tyrosine kinase ACK1. Substrate specificity, authphosphorylation, and interaction with Hck. J Biol Chem. 2003;278:47713-23 pubmed
    ..Our data suggest that Hck is a novel binding partner for ACK1 that can regulate ACK1 activity by phosphorylation. ..
  86. Zadeh A, Cheng Y, Xu H, Wong N, Wang Z, Goonasekara C, et al. Kif5b is an essential forward trafficking motor for the Kv1.5 cardiac potassium channel. J Physiol. 2009;587:4565-74 pubmed publisher
    ..5 in a tetracycline inducible system blocked surface expression of the channel in both HEK293 cells and H9c2 cardiomyoblasts. Thus, Kif5b is essential to anterograde trafficking of a cardiac voltage-gated potassium channel. ..
  87. Poparic I, Schreibmayer W, Schoser B, Desoye G, Gorischek A, Miedl H, et al. Four and a half LIM protein 1C (FHL1C): a binding partner for voltage-gated potassium channel K(v1.5). PLoS ONE. 2011;6:e26524 pubmed publisher
    ..5) with FHL1C in Xenopus laevis oocytes markedly reduced K(+) currents when compared to oocytes expressing K(v1.5) only. We here present the first evidence on a biological relevance of FHL1C. ..
  88. He W, Fang N, Wang R, Wu Y, Zeng G, Guan C, et al. Fine Mapping of a New Race-Specific Blast Resistance Gene, Pi-hk2, in Japonica Heikezijing from Taihu Region of China. Phytopathology. 2017;107:84-91 pubmed
    ..10 and phenotypic variance of 46.19% and might be a major QTL, named Pi-hk2. The line RIL84 with Pi-hk2 derived from a cross between Heikezijing and Suyunuo was selected as Pi-hk2 gene donor ..
  89. Hu H, Zhou J, Sun Q, Yu X, Zhang H, Ma X, et al. [Effects of ethanol on action potential of rat myocardium and human Kv1.5 channel]. Sheng Li Xue Bao. 2011;63:219-24 pubmed
    ..0-200.0 mmol/L ethanol prolong APD significantly in isolated rat atrium and papillary. The prolonged effect on APD in isolated myocardium may be due to the inhibition of the Kv1.5 channel currents. ..
  90. Munoz C, Tóvolli R, Sopjani M, Alesutan I, Lam R, Seebohm G, et al. Activation of voltage gated K? channel Kv1.5 by ?-catenin. Biochem Biophys Res Commun. 2012;417:692-6 pubmed publisher
    ..5 requires the same protein domains that are required for association of ?-catenin with cadherin. The experiments disclose a completely novel function of ?-catenin, i.e. the regulation of Kv1.5 channel activity. ..
  91. Macias A, De La Cruz A, Prieto A, Peraza D, Tamkun M, Gonzalez T, et al. PKC inhibition results in a Kv 1.5 + Kv ?1.3 pharmacology closer to Kv 1.5 channels. Br J Pharmacol. 2014;171:4914-26 pubmed publisher
    ..5 channels suggests that both processes are dependent on PKC-mediated phosphorylation. These results may have clinical relevance in diseases that are characterized by alterations in kinase activity. ..
  92. Pérez Verdaguer M, Capera J, Martínez Mármol R, Camps M, Comes N, Tamkun M, et al. Caveolin interaction governs Kv1.3 lipid raft targeting. Sci Rep. 2016;6:22453 pubmed publisher
    ..Our results identify a caveolin-binding domain in Kv1 channels and highlight the mechanisms that govern the regulation of channel surface localization during cellular processes. ..