KCNA10

Summary

Gene Symbol: KCNA10
Description: potassium voltage-gated channel subfamily A member 10
Alias: Kcn1, Kv1.8, potassium voltage-gated channel subfamily A member 10, cyclic GMP gated potassium channel, potassium channel, voltage gated shaker related subfamily A, member 10, potassium voltage-gated channel, shaker-related subfamily, member 10, voltage-gated potassium channel subunit Kv1.8
Species: human
Products:     KCNA10

Top Publications

  1. Lee S, Conrad T, Jones S, Lagziel A, Starost M, Belyantseva I, et al. A null mutation of mouse Kcna10 causes significant vestibular and mild hearing dysfunction. Hear Res. 2013;300:1-9 pubmed publisher
    b>KCNA10 is a voltage gated potassium channel that is expressed in the inner ear...
  2. Ovsepian S, LeBerre M, Steuber V, O Leary V, Leibold C, Oliver Dolly J. Distinctive role of KV1.1 subunit in the biology and functions of low threshold K(+) channels with implications for neurological disease. Pharmacol Ther. 2016;159:93-101 pubmed publisher
    ..Future research and interpretation of emerging data should afford new insights towards a better understanding of the role of KV1.1 in integrative mechanisms of neurons and synaptic functions under normal and disease conditions. ..
  3. Asgari S, Hashemi H, Jafarzadehpur E, Mohamadi A, Rezvan F, Fotouhi A. OPD-Scan III: a repeatability and inter-device agreement study of a multifunctional device in emmetropia, ametropia, and keratoconus. Int Ophthalmol. 2016;36:697-705 pubmed publisher
    ..All device functions had acceptable precision in groups with emmetropia, ametropia, and KCN1, except spherical error in ammetropics (0.97 D)...
  4. Li J, Yoshikawa A, Brennan M, Ramsey T, Meltzer H. Genetic predictors of antipsychotic response to lurasidone identified in a genome wide association study and by schizophrenia risk genes. Schizophr Res. 2018;192:194-204 pubmed publisher
    ..g. KCNA10, KCNAB1, KCNK9 and CACNA2D3). Some genes predicted response for patients with both European and African Ancestries...
  5. Nanayakkara S, Senevirathna S, Parahitiyawa N, Abeysekera T, Chandrajith R, Ratnatunga N, et al. Whole-exome sequencing reveals genetic variants associated with chronic kidney disease characterized by tubulointerstitial damages in North Central Region, Sri Lanka. Environ Health Prev Med. 2015;20:354-9 pubmed publisher
    ..Association study revealed rs34970857 (c.658G > A/p.V220M) located in the KCNA10 gene encoding a voltage-gated K channel as the most promising SNP with the highest odds ratio of 1.74...
  6. Tian S, Liu W, Wu Y, Rafi H, Segal A, Desir G. Regulation of the voltage-gated K+ channel KCNA10 by KCNA4B, a novel beta-subunit. Am J Physiol Renal Physiol. 2002;283:F142-9 pubmed
    ..The aim of the present study was to isolate accessory proteins for KCNA10, a novel Kv channel alpha-subunit functionally related to Kv and cyclic nucleotide-gated cation channels...
  7. Yao X, Tian S, Chan H, Biemesderfer D, Desir G. Expression of KCNA10, a voltage-gated K channel, in glomerular endothelium and at the apical membrane of the renal proximal tubule. J Am Soc Nephrol. 2002;13:2831-9 pubmed
    Potassium (K) channels regulate cell membrane potential and modulate a number of important cellular functions. KCNA10 is a cyclic nucleotide-gated, voltage-activated K channel that is detected in kidney, heart, and aorta by Northern blot ..
  8. Naranjo D, Moldenhauer H, Pincuntureo M, Díaz Franulic I. Pore size matters for potassium channel conductance. J Gen Physiol. 2016;148:277-91 pubmed publisher
    ..Here we raise the idea that the physical dimensions of the hydrophobic internal vestibule limit ion transport in K(+) channels, accounting for their diversity in unitary conductance. ..
  9. Landes G, Curran M, Keating M. Molecular characterization and refined genomic localization of three human potassium ion channel genes. Cytogenet Cell Genet. 1995;70:280-4 pubmed
    ..33, 1p13.1-->p21.1 and 19q13.32-->q13.33, respectively. Using FISH, each of these clones has been finely mapped to a different human chromosome indicating a significant dispersion of K+ channel sequences in the human genome. ..

More Information

Publications11

  1. Orias M, Bray Ward P, Curran M, Keating M, Desir G. Genomic localization of the human gene for KCNA10, a cGMP-activated K channel. Genomics. 1997;42:33-7 pubmed
    ..b>KCNA10 represents a new class of K channel specifically regulated by cGMP and postulated to mediate the effects of ..
  2. Lang R, Lee G, Liu W, Tian S, Rafi H, Orias M, et al. KCNA10: a novel ion channel functionally related to both voltage-gated potassium and CNG cation channels. Am J Physiol Renal Physiol. 2000;278:F1013-21 pubmed
    ..3 microA at +60 mV), the human homolog (KCNA10) was isolated, and its expression was optimized in oocytes...