Gene Symbol: KAT2A
Description: lysine acetyltransferase 2A
Alias: GCN5, GCN5L2, PCAF-b, hGCN5, histone acetyltransferase KAT2A, GCN5 (general control of amino-acid synthesis, yeast, homolog)-like 2, General control of amino acid synthesis, yeast, homolog-like 2, K(lysine) acetyltransferase 2A, STAF97, general control of amino acid synthesis protein 5-like 2, histone acetyltransferase GCN5, histone succinyltransferase KAT2A, hsGCN5
Species: human
Products:     KAT2A

Top Publications

  1. Col E, Caron C, Seigneurin Berny D, Gracia J, Favier A, Khochbin S. The histone acetyltransferase, hGCN5, interacts with and acetylates the HIV transactivator, Tat. J Biol Chem. 2001;276:28179-84 pubmed
    ..Here we report that hGCN5, a well known histone acetyltransferase, specifically interacts with and acetylates the human immunodeficiency ..
  2. Martinez E, Palhan V, Tjernberg A, Lymar E, Gamper A, Kundu T, et al. Human STAGA complex is a chromatin-acetylating transcription coactivator that interacts with pre-mRNA splicing and DNA damage-binding factors in vivo. Mol Cell Biol. 2001;21:6782-95 pubmed
    b>GCN5 is a histone acetyltransferase (HAT) originally identified in Saccharomyces cerevisiae and required for transcription of specific genes within chromatin as part of the SAGA (SPT-ADA-GCN5 acetylase) coactivator complex...
  3. Liu X, Tesfai J, Evrard Y, Dent S, Martinez E. c-Myc transformation domain recruits the human STAGA complex and requires TRRAP and GCN5 acetylase activity for transcription activation. J Biol Chem. 2003;278:20405-12 pubmed
    ..the transformation-transactivation domain-associated protein (TRRAP) and the human histone acetyltransferase (HAT) GCN5. TRRAP and GCN5 are components of a variety of shared and distinct multiprotein HAT complexes with diverse ..
  4. Liu X, Vorontchikhina M, Wang Y, Faiola F, Martinez E. STAGA recruits Mediator to the MYC oncoprotein to stimulate transcription and cell proliferation. Mol Cell Biol. 2008;28:108-21 pubmed
    ..Here we report physical interactions between the human HAT complex STAGA (SPT3-TAF9-GCN5-acetylase) and a "core" form of the Mediator complex during transcription activation by the MYC ..
  5. Atanassov B, Evrard Y, Multani A, Zhang Z, Tora L, Devys D, et al. Gcn5 and SAGA regulate shelterin protein turnover and telomere maintenance. Mol Cell. 2009;35:352-64 pubmed publisher
    ..Here, we show that deletion of Gcn5 leads to telomere dysfunction in mouse and human cells...
  6. Jin Q, Yu L, Wang L, Zhang Z, Kasper L, Lee J, et al. Distinct roles of GCN5/PCAF-mediated H3K9ac and CBP/p300-mediated H3K18/27ac in nuclear receptor transactivation. EMBO J. 2011;30:249-62 pubmed publisher
    Histone acetyltransferases (HATs) GCN5 and PCAF (GCN5/PCAF) and CBP and p300 (CBP/p300) are transcription co-activators. However, how these two distinct families of HATs regulate gene activation remains unclear...
  7. Wang L, Mizzen C, Ying C, Candau R, Barlev N, Brownell J, et al. Histone acetyltransferase activity is conserved between yeast and human GCN5 and is required for complementation of growth and transcriptional activation. Mol Cell Biol. 1997;17:519-27 pubmed
    Yeast and human ADA2 and GCN5 (y- and hADA2 and y- and hGCN5, respectively) have been shown to potentiate transcription in vivo and may function as adaptors to bridge physical interactions between DNA-bound activators and the basal ..
  8. Kikuchi H, Takami Y, Nakayama T. GCN5: a supervisor in all-inclusive control of vertebrate cell cycle progression through transcription regulation of various cell cycle-related genes. Gene. 2005;347:83-97 pubmed
    ..To clarify participatory in vivo roles of two such enzymes known as GCN5 and PCAF, we generated homozygous DT40 mutants, DeltaGCN5 and DeltaPCAF, devoid of two alleles of each of the GCN5 ..
  9. Paolinelli R, Mendoza Maldonado R, Cereseto A, Giacca M. Acetylation by GCN5 regulates CDC6 phosphorylation in the S phase of the cell cycle. Nat Struct Mol Biol. 2009;16:412-20 pubmed publisher
    ..containing Cyclin A, cyclin-dependent kinase (CDK)-2 and the acetyltransferase general control nonderepressible 5 (GCN5)...

More Information

Publications105 found, 100 shown here

  1. Terreni M, Valentini P, Liverani V, Gutierrez M, Di Primio C, Di Fenza A, et al. GCN5-dependent acetylation of HIV-1 integrase enhances viral integration. Retrovirology. 2010;7:18 pubmed publisher
    ..In this study we demonstrate that another cellular HAT, GCN5, acetylates IN leading to enhanced 3'-end processing and strand transfer activities...
  2. Gangloff Y, Pointud J, Thuault S, Carre L, Romier C, Muratoglu S, et al. The TFIID components human TAF(II)140 and Drosophila BIP2 (TAF(II)155) are novel metazoan homologues of yeast TAF(II)47 containing a histone fold and a PHD finger. Mol Cell Biol. 2001;21:5109-21 pubmed
    ..These conserved domains are critical for yTAF(II)65 function in vivo. Our results therefore identify metazoan homologues of yTAF(II)47 and yTAF(II)65. ..
  3. Wang Y, Faiola F, Xu M, Pan S, Martinez E. Human ATAC Is a GCN5/PCAF-containing acetylase complex with a novel NC2-like histone fold module that interacts with the TATA-binding protein. J Biol Chem. 2008;283:33808-15 pubmed publisher
    Eukaryotic GCN5 acetyltransferases influence diverse biological processes by acetylating histones and non-histone proteins and regulating chromatin and gene-specific transcription as part of multiprotein complexes...
  4. Brand M, Moggs J, Oulad Abdelghani M, Lejeune F, Dilworth F, Stevenin J, et al. UV-damaged DNA-binding protein in the TFTC complex links DNA damage recognition to nucleosome acetylation. EMBO J. 2001;20:3187-96 pubmed
    ..TFTC containing the GCN5 acetyltransferase acetylates histone H3 in a nucleosomal context...
  5. Lang S, McMahon S, Cole M, Hearing P. E2F transcriptional activation requires TRRAP and GCN5 cofactors. J Biol Chem. 2001;276:32627-34 pubmed
    ..the E2F-4 transactivation domain and show that E2F-1 and E2F-4 transactivation domains bind the acetyltransferase GCN5 and cofactor TRRAP in vivo...
  6. Cavusoglu N, Brand M, Tora L, Van Dorsselaer A. Novel subunits of the TATA binding protein free TAFII-containing transcription complex identified by matrix-assisted laser desorption/ionization-time of flight mass spectrometry following one-dimensional gel electrophoresis. Proteomics. 2003;3:217-23 pubmed
    ..This new characterization of TFTC complex confirmed the presence of already described subunits (TRRAP, GCN5, SAP130/KIA0017, TAF(II)150, TAF(II)135, TAF(II)100, TAF(II)80, TAF(II)20, SPT3 and PAF65beta)...
  7. Palhan V, Chen S, Peng G, Tjernberg A, Gamper A, Fan Y, et al. Polyglutamine-expanded ataxin-7 inhibits STAGA histone acetyltransferase activity to produce retinal degeneration. Proc Natl Acad Sci U S A. 2005;102:8472-7 pubmed
    ..Here, we report that ataxin-7 is an integral component of the mammalian STAGA (SPT3-TAF9-ADA-GCN5 acetyltransferase) transcription coactivator complex, interacts directly with the GCN5 histone acetyltransferase ..
  8. Cereseto A, Manganaro L, Gutierrez M, Terreni M, Fittipaldi A, Lusic M, et al. Acetylation of HIV-1 integrase by p300 regulates viral integration. EMBO J. 2005;24:3070-81 pubmed
    ..This is the first demonstration that HIV-1 IN activity is specifically regulated by post-translational modification. ..
  9. Sabò A, Lusic M, Cereseto A, Giacca M. Acetylation of conserved lysines in the catalytic core of cyclin-dependent kinase 9 inhibits kinase activity and regulates transcription. Mol Cell Biol. 2008;28:2201-12 pubmed publisher
    ..Here we show that cellular GCN5 and P/CAF, members of the GCN5-related N-acetyltransferase family of histone acetyltransferases, regulate CDK9 ..
  10. Brand M, Yamamoto K, Staub A, Tora L. Identification of TATA-binding protein-free TAFII-containing complex subunits suggests a role in nucleosome acetylation and signal transduction. J Biol Chem. 1999;274:18285-9 pubmed
    ..TFTC, similar to other TBP-free TAFII complexes (yeast SAGA, hSTAGA, and hPCAF) contains the acetyltransferase hGCN5 and is able to acetylate histones in both a free and a nucleosomal context...
  11. Helmlinger D, Hardy S, Sasorith S, Klein F, Robert F, Weber C, et al. Ataxin-7 is a subunit of GCN5 histone acetyltransferase-containing complexes. Hum Mol Genet. 2004;13:1257-65 pubmed
    ..A putative ataxin-7 yeast orthologue (SGF73) has been identified recently as a new component of the SAGA (Spt/Ada/Gcn5 acetylase) multisubunit complex, a coactivator required for transcription of a subset of RNA polymerase II-..
  12. Frontini M, Soutoglou E, Argentini M, Bole Feysot C, Jost B, Scheer E, et al. TAF9b (formerly TAF9L) is a bona fide TAF that has unique and overlapping roles with TAF9. Mol Cell Biol. 2005;25:4638-49 pubmed
    ..regulatory multiprotein complexes containing TAFs has been described (called SAGA, TFTC, STAGA, and PCAF/GCN5)...
  13. Orpinell M, Fournier M, Riss A, Nagy Z, Krebs A, Frontini M, et al. The ATAC acetyl transferase complex controls mitotic progression by targeting non-histone substrates. EMBO J. 2010;29:2381-94 pubmed publisher
    ..Here, we show that the Gcn5-containing histone acetyl transferase complex, Ada Two A containing (ATAC), controls mitotic progression through ..
  14. Ji Y, Wu Z, Dai Z, Sun K, Wang J, Wu G. Nutritional epigenetics with a focus on amino acids: implications for the development and treatment of metabolic syndrome. J Nutr Biochem. 2016;27:1-8 pubmed publisher
    ..DNA demethylases, histone acetylase (lysine acetyltransferase), general control nonderepressible 5 (GCN5)-related N-acetyltransferase (a superfamily of acetyltransferase) and histone deacetylase. Amino acids (e.g...
  15. Jefferson W, Chevalier D, Phelps J, Cantor A, Padilla Banks E, Newbold R, et al. Persistently altered epigenetic marks in the mouse uterus after neonatal estrogen exposure. Mol Endocrinol. 2013;27:1666-77 pubmed publisher
    ..reductions in histone methyltransferase enhancer of zeste homolog 2 (EZH2), histone lysine acetyltransferase 2A (KAT2A), and histone deacetylases HDAC1, HDAC2, and HDAC3...
  16. Guo L, Ganguly A, Sun L, Suo F, Du L, Russell P. Global Fitness Profiling Identifies Arsenic and Cadmium Tolerance Mechanisms in Fission Yeast. G3 (Bethesda). 2016;6:3317-3333 pubmed publisher
    ..whereas cadmium-specific pathways included plasma membrane and vacuolar transporters, as well as Spt-Ada-Gcn5-acetyltransferase (SAGA) transcriptional coactivator that controls expression of key genes required for cadmium ..
  17. Basnet H, Su X, Tan Y, Meisenhelder J, Merkurjev D, Ohgi K, et al. Tyrosine phosphorylation of histone H2A by CK2 regulates transcriptional elongation. Nature. 2014;516:267-71 pubmed publisher
    ..both CK2 inhibition and the H2A(Y57F) mutation enhance H2B deubiquitination activity of the Spt-Ada-Gcn5 acetyltransferase (SAGA) complex, suggesting a critical role of this phosphorylation in coordinating the activity ..
  18. Cramer T, Rosenberg T, Kisliouk T, Meiri N. Early-life epigenetic changes along the corticotropin-releasing hormone (CRH) gene influence resilience or vulnerability to heat stress later in life. Mol Psychiatry. 2018;: pubmed publisher
    ..Finally, the adjacent histone recruited the histone acetylation enzyme GCN5 to this complex, which increased H3K27ac during harsh, but not moderate heat conditioning...
  19. Mahrez W, Arellano M, Moreno Romero J, Nakamura M, Shu H, Nanni P, et al. H3K36ac Is an Evolutionary Conserved Plant Histone Modification That Marks Active Genes. Plant Physiol. 2016;170:1566-77 pubmed publisher
    ..H3K36ac overlaps with H3K4me3 and the H2A.Z histone variant. The histone acetyl transferase GCN5 and the histone deacetylase HDA19 are required for H3K36ac homeostasis...
  20. Sidhu K, Kumar V. c-ETS transcription factors play an essential role in the licensing of human MCM4 origin of replication. Biochim Biophys Acta. 2015;1849:1319-28 pubmed publisher
    ..by an active chromatin distinguished by acetylated histone H3 orchestrated by histone acetyl transferase GCN5 and followed by HBO1 mediated histone H4 acetylation...
  21. Tyler C, Hafez A, Solomon E, Allan A. Developmental exposure to 50 parts-per-billion arsenic influences histone modifications and associated epigenetic machinery in a region- and sex-specific manner in the adult mouse brain. Toxicol Appl Pharmacol. 2015;288:40-51 pubmed publisher
    ..increased histone 3K9 acetylation levels in the male DG along with histone acetyltransferase (HAT) expression of GCN5 and decreased H3K9ac levels in the male FC along with decreased HAT expression of GCN5 and PCAF...
  22. Damiani E, Puebla Osorio N, Lege B, Liu J, Neelapu S, Ullrich S. Platelet activating factor-induced expression of p21 is correlated with histone acetylation. Sci Rep. 2017;7:41959 pubmed publisher
    ..PAF-treatment had no effect on other acetylating enzymes (GCN5L2, PCAF) indicating it is not a global activator of histone acetylation...
  23. Bomsztyk K, Flanagin S, Mar D, Mikula M, Johnson A, ZAGER R, et al. Synchronous recruitment of epigenetic modifiers to endotoxin synergistically activated Tnf-? gene in acute kidney injury. PLoS ONE. 2013;8:e70322 pubmed publisher
    ..but not by LPS, while others were induced by either I/R or LPS and exhibited endotoxin hyperresponsive patterns (GCN5, CBP and p300)...
  24. Yu S, Chang Y, Chen Y. Deletion of ADA2 Increases Antifungal Drug Susceptibility and Virulence in Candida glabrata. Antimicrob Agents Chemother. 2018;62: pubmed publisher
    ..Ada2, a component serving as a transcription adaptor of the Spt-Ada-Gcn5 acetyltransferase (SAGA) complex, is required for antifungal drug tolerance and virulence in C...
  25. Gao F, Ma N, Zhou H, Wang Q, Zhang H, Wang P, et al. Zinc oxide nanoparticles-induced epigenetic change and G2/M arrest are associated with apoptosis in human epidermal keratinocytes. Int J Nanomedicine. 2016;11:3859-74 pubmed publisher
    ..methyltransferase genes G9a and GLP was also increased upon treatment with ZnO NPs, and the acetyltransferase genes GCN5, P300, and CBP were downregulated...
  26. Li Y, Jaramillo Lambert A, Hao J, Yang Y, Zhu W. The stability of histone acetyltransferase general control non-derepressible (Gcn) 5 is regulated by Cullin4-RING E3 ubiquitin ligase. J Biol Chem. 2011;286:41344-52 pubmed publisher
    ..We have recently identified a functional link between Gcn5 and acidic nucleoplasmic DNA-binding protein 1 (And-1) that is elevated in multiple cancer cells and is essential ..
  27. Saxena S, Purushothaman S, Meghah V, Bhatti B, Poruri A, Meena Lakshmi M, et al. Role of annexin gene and its regulation during zebrafish caudal fin regeneration. Wound Repair Regen. 2016;24:551-9 pubmed publisher
    ..trimethylation, H3K4 trimethylation and H3K9 dimethylation along with their respective regulatory genes, such as GCN5, SETd8b, SETD7/9, and SUV39h1, were differentially regulated in the regenerating fin at various time points of post-..
  28. Chen J, Luo Q, Yuan Y, Huang X, Cai W, Li C, et al. Pygo2 associates with MLL2 histone methyltransferase and GCN5 histone acetyltransferase complexes to augment Wnt target gene expression and breast cancer stem-like cell expansion. Mol Cell Biol. 2010;30:5621-35 pubmed publisher
    ..This work now links mechanistically Pygo2's role in histone modification to its enhancement of the Wnt-dependent transcriptional program and cancer stem-like cell expansion. ..
  29. Srivastava R, Kaur A, Sharma C, Karthikeyan S. Structural characterization of ribT from Bacillus subtilis reveals it as a GCN5-related N-acetyltransferase. J Struct Biol. 2018;202:70-81 pubmed publisher
    ..Our structural study reveals that bribT is a member of GCN5-related N-acetyltransferase (GNAT) superfamily and contains all the four conserved structural motifs that have been ..
  30. Martel A, Brar H, Mayer B, Charron J. Diversification of the Histone Acetyltransferase GCN5 through Alternative Splicing in Brachypodium distachyon. Front Plant Sci. 2017;8:2176 pubmed publisher
    ..Alternative transcripts of the SAGA complex's enzymatic subunit GCN5 have been identified in Brachypodium distachyon...
  31. Janer A, Werner A, Takahashi Fujigasaki J, Daret A, Fujigasaki H, Takada K, et al. SUMOylation attenuates the aggregation propensity and cellular toxicity of the polyglutamine expanded ataxin-7. Hum Mol Genet. 2010;19:181-95 pubmed publisher
    ..Our results demonstrate an influence of SUMOylation on the multistep aggregation process of ATXN7 and implicate a role for ATXN7 SUMOylation in SCA7 pathogenesis...
  32. Pusalkar M, Suri D, Kelkar A, Bhattacharya A, Galande S, Vaidya V. Early stress evokes dysregulation of histone modifiers in the medial prefrontal cortex across the life span. Dev Psychobiol. 2016;58:198-210 pubmed publisher
    ..While specific histone modifiers (Kat2a, Smyd3, and Suv420h1) and the sirtuin, Sirt4 were downregulated across life within the mPFC of ES animals, namely ..
  33. Nasuno R, Hirase S, Norifune S, Watanabe D, Takagi H. Structure-based molecular design for thermostabilization of N-acetyltransferase Mpr1 involved in a novel pathway of L-arginine synthesis in yeast. J Biochem. 2016;159:271-7 pubmed publisher
    ..analysis demonstrated that the overall structure of Mpr1 is a typical folding among proteins in the Gcn5-related N-acetyltransferase superfamily, and also provided clues to the design of mutations for improvement of the ..
  34. Wang Y, Yun C, Gao B, Xu Y, Zhang Y, Wang Y, et al. The Lysine Acetyltransferase GCN5 Is Required for iNKT Cell Development through EGR2 Acetylation. Cell Rep. 2017;20:600-612 pubmed publisher
    ..We found that the histone acetyltransferase general control non-derepressible 5 (GCN5) is essential for iNKT cell development during the maturation stage...
  35. Col E, Gilquin B, Caron C, Khochbin S. Tat-controlled protein acetylation. J Biol Chem. 2002;277:37955-60 pubmed
    ..These results demonstrate that Tat is able to selectively modulate cellular protein acetylation by nuclear HATs and therefore to take over this specific signaling system in cells. ..
  36. Demény M, Soutoglou E, Nagy Z, Scheer E, Janoshazi A, Richardot M, et al. Identification of a small TAF complex and its role in the assembly of TAF-containing complexes. PLoS ONE. 2007;2:e316 pubmed
    ..complexes having histone acetyl transferase (HAT) activity, and containing TAFs, includes TFTC, STAGA and the PCAF/GCN5 complex...
  37. Hosseini S, Hajian M, Ostadhosseini S, Forouzanfar M, Abedi P, Jafarpour F, et al. Contrasting effects of G1.2/G2.2 and SOF1/SOF2 embryo culture media on pre- and post-implantation development of non-transgenic and transgenic cloned goat embryos. Reprod Biomed Online. 2015;31:372-83 pubmed publisher
    ..expression profiling of 17 developmentally important genes revealed that: (i) SOX2, FOXD3, IFNT, FZD, FGFR4, ERK1, GCN5, PCAF, BMPR1, SMAD5, ALK4, CDC25 and LIFR were significantly induced in blastocysts developed in SOF1/SOF2 but not ..
  38. Bar Ziv R, Voichek Y, Barkai N. Chromatin dynamics during DNA replication. Genome Res. 2016;26:1245-56 pubmed publisher
    ..H3K9ac was fully dependent on the acetyltransferase Rtt109, while expression-guided H3K9ac was deposited by Gcn5. Further, topoisomerase depletion intensified H3K9ac in front of the replication fork and in sites where RNA ..
  39. Sakai M, Tujimura Hayakawa T, Yagi T, Yano H, Mitsushima M, Unoki Kubota H, et al. The GCN5-CITED2-PKA signalling module controls hepatic glucose metabolism through a cAMP-induced substrate switch. Nat Commun. 2016;7:13147 pubmed publisher
    ..Here we show that GCN5 functions both as a histone acetyltransferase (HAT) to activate fasting gluconeogenesis and as an acetyltransferase ..
  40. Reissig K, Silver A, Hartig R, Schinlauer A, Walluscheck D, Guenther T, et al. Chk1 Promotes DNA Damage Response Bypass following Oxidative Stress in a Model of Hydrogen Peroxide-Associated Ulcerative Colitis through JNK Inactivation and Chromatin Binding. Oxid Med Cell Longev. 2017;2017:9303158 pubmed publisher
    ..Targeting chromatin-bound Chk1, GCN5, PCAF, and p300/CBP could be a novel therapeutic strategy to prevent UC-related tumor progression.
  41. Ablack J, Cohen M, Thillainadesan G, Fonseca G, Pelka P, Torchia J, et al. Cellular GCN5 is a novel regulator of human adenovirus E1A-conserved region 3 transactivation. J Virol. 2012;86:8198-209 pubmed publisher
    ..The N terminus of E1A binds GCN5, a cellular lysine acetyltransferase (KAT)...
  42. Chen L, Wei T, Si X, Wang Q, Li Y, Leng Y, et al. Lysine acetyltransferase GCN5 potentiates the growth of non-small cell lung cancer via promotion of E2F1, cyclin D1, and cyclin E1 expression. J Biol Chem. 2013;288:14510-21 pubmed publisher
    The lysine acetyltransferases play crucial but complex roles in cancer development. GCN5 is a lysine acetyltransferase that generally regulates gene expression, but its role in cancer development remains largely unknown...
  43. Jin Q, Zhuang L, Lai B, Wang C, Li W, Dolan B, et al. Gcn5 and PCAF negatively regulate interferon-? production through HAT-independent inhibition of TBK1. EMBO Rep. 2014;15:1192-201 pubmed publisher
    ..Previous studies showed that Gcn5 (Kat2a), a histone acetyltransferase (HAT) with partial functional redundancy with PCAF (Kat2b), and Gcn5/PCAF-mediated ..
  44. Hultquist J, Schumann K, Woo J, Manganaro L, McGregor M, DOUDNA J, et al. A Cas9 Ribonucleoprotein Platform for Functional Genetic Studies of HIV-Host Interactions in Primary Human T Cells. Cell Rep. 2016;17:1438-1452 pubmed publisher
    ..This technology should accelerate target validation for pharmaceutical and cell-based therapies to cure HIV infection. ..
  45. Andika I, Jamal A, Kondo H, Suzuki N. SAGA complex mediates the transcriptional up-regulation of antiviral RNA silencing. Proc Natl Acad Sci U S A. 2017;114:E3499-E3506 pubmed publisher
    ..Screening for GFP-negative colonies allowed the identification of sgf73, a component of the SAGA (Spt-Ada-Gcn5 acetyltransferase) complex, a well-known transcriptional coactivator...
  46. He H, Wang J, Liu T. UV-Induced RPA1 Acetylation Promotes Nucleotide Excision Repair. Cell Rep. 2017;20:2010-2025 pubmed publisher
    ..Herein, we show that the 70-kDa subunit of RPA (RPA1) is acetylated on lysine 163 by the acetyltransferases GCN5 and PCAF and that such acetylation is reversed principally via the action of the deacetylase HDAC6...
  47. Chung H, Sze S, Tay A, Lin V. Acetylation at lysine 183 of progesterone receptor by p300 accelerates DNA binding kinetics and transactivation of direct target genes. J Biol Chem. 2014;289:2180-94 pubmed publisher
    ..The effect may be mediated by enhancing Ser-294 phosphorylation. ..
  48. Zhang N, Ichikawa W, Faiola F, Lo S, Liu X, Martinez E. MYC interacts with the human STAGA coactivator complex via multivalent contacts with the GCN5 and TRRAP subunits. Biochim Biophys Acta. 2014;1839:395-405 pubmed publisher
    ..protein (TRRAP), a subunit of different histone acetyltransferase (HAT) complexes such as the human "SPT3-TAF9-GCN5 Acetyltransferase" (STAGA) complex involved in MYC transactivation of the TERT gene...
  49. Waters R, van Eijk P, Reed S. Histone modification and chromatin remodeling during NER. DNA Repair (Amst). 2015;36:105-13 pubmed publisher
    ..We focused on how GG-NER relates to histone acetylation for its functioning and we identified the histone acetyltransferase Gcn5 and acetylation at lysines 9/14 of histone H3 as a major factor in enabling efficient repair...
  50. Lee D, Goldberg A. Muscle Wasting in Fasting Requires Activation of NF-κB and Inhibition of AKT/Mechanistic Target of Rapamycin (mTOR) by the Protein Acetylase, GCN5. J Biol Chem. 2015;290:30269-79 pubmed publisher
    ..Knockdown of GCN5 with shRNA or a dominant-negative GCN5 or overexpression of SIRT1 decreased p65K310 acetylation and muscle wasting ..
  51. Carabetta V, Cristea I. Regulation, Function, and Detection of Protein Acetylation in Bacteria. J Bacteriol. 2017;199: pubmed publisher
    ..The opposing actions of Gcn5-related N-acetyltransferases (GNATs) and deacetylases, including sirtuins, provide the enzymatic control of ..
  52. Sisakhtnezhad S, Heshmati P. Comparative analysis of single-cell RNA sequencing data from mouse spermatogonial and mesenchymal stem cells to identify differentially expressed genes and transcriptional regulators of germline cells. J Cell Physiol. 2017;: pubmed publisher
    ..Our findings also indicated that MEIS1, SMC3, TAF1, KAT2A, STAT3, GTF3C2, SIN3A, BDP1, PHC1 and EGR1 are the main central regulators of DEGs in mSSCs...
  53. Park J, Wood M, Cole M. BAF53 forms distinct nuclear complexes and functions as a critical c-Myc-interacting nuclear cofactor for oncogenic transformation. Mol Cell Biol. 2002;22:1307-16 pubmed
    ..previously reported the identification and functional characterization of four different c-Myc cofactors: TRRAP, hGCN5, TIP49, and TIP48...
  54. Kelly T, Lerin C, Haas W, Gygi S, Puigserver P. GCN5-mediated transcriptional control of the metabolic coactivator PGC-1beta through lysine acetylation. J Biol Chem. 2009;284:19945-52 pubmed publisher
    ..distributed along the length of the protein by the acetyl transferase general control of amino-acid synthesis (GCN5) and that this acetylation reaction is reversed by the deacetylase sirtuin 1 (SIRT1)...
  55. Ramachandran S, Haddad D, Li C, Le M, Ling A, So C, et al. The SAGA Deubiquitination Module Promotes DNA Repair and Class Switch Recombination through ATM and DNAPK-Mediated ?H2AX Formation. Cell Rep. 2016;15:1554-1565 pubmed publisher
    ..We found that Usp22, Eny2, and Atxn7, members of the Spt-Ada-Gcn5-acetyltransferase (SAGA) deubiquitination module, are required for deubiquitination of H2BK120ub following DNA ..
  56. Lu Y, Liu X, Liu W, Ye B. Identification and characterization of two types of amino acid-regulated acetyltransferases in actinobacteria. Biosci Rep. 2017;37: pubmed publisher
    One hundred and fifty GCN5-like acetyltransferases with amino acid-binding (ACT)-GCN5-related N-acetyltransferase (GNAT) domain organization have been identified in actinobacteria...
  57. Gazdag E, Jacobi U, van Kruijsbergen I, Weeks D, Veenstra G. Activation of a T-box-Otx2-Gsc gene network independent of TBP and TBP-related factors. Development. 2016;143:1340-50 pubmed publisher
    ..Strikingly, recruitment of Gcn5 (also known as Kat2a), a co-activator that has been implicated in transcription initiation, to TFI gene promoters is increased upon ..
  58. Yamaguchi Y, Kurokawa M, Imai Y, Izutsu K, Asai T, Ichikawa M, et al. AML1 is functionally regulated through p300-mediated acetylation on specific lysine residues. J Biol Chem. 2004;279:15630-8 pubmed
    ..Taken together, these data indicate that acetylation of AML1 through p300 is a critical manner of posttranslational modification and identify a novel mechanism for regulating the function of AML1. ..
  59. Tian X, Zhao F, Cheng Z, Zhou M, Zhi X, Li J, et al. GCN5 acetyltransferase inhibits PGC1?-induced hepatitis B virus biosynthesis. Virol Sin. 2013;28:216-22 pubmed publisher
    ..Here, we showed that the acetyltransferase General Control Non-repressed Protein 5 (GCN5) acetylated PGC1?, leading to alteration of PGC1? from a transcriptionally active state into an inactive state...
  60. Koppen A, Houtman R, Pijnenburg D, Jeninga E, Ruijtenbeek R, Kalkhoven E. Nuclear receptor-coregulator interaction profiling identifies TRIP3 as a novel peroxisome proliferator-activated receptor gamma cofactor. Mol Cell Proteomics. 2009;8:2212-26 pubmed publisher
    ..These findings indicate that NR-coregulator interaction profiling may be a useful tool for drug development and biological discovery. ..
  61. Sun T, He J, Liang Q, Ren L, Yan T, Yu T, et al. LncRNA GClnc1 Promotes Gastric Carcinogenesis and May Act as a Modular Scaffold of WDR5 and KAT2A Complexes to Specify the Histone Modification Pattern. Cancer Discov. 2016;6:784-801 pubmed publisher
    ..Mechanistically, GClnc1 bound WDR5 (a key component of histone methyltransferase complex) and KAT2A histone acetyltransferase, acted as a modular scaffold of WDR5 and KAT2A complexes, coordinated their localization,..
  62. Masumi A, Wang I, Lefebvre B, Yang X, Nakatani Y, Ozato K. The histone acetylase PCAF is a phorbol-ester-inducible coactivator of the IRF family that confers enhanced interferon responsiveness. Mol Cell Biol. 1999;19:1810-20 pubmed
    ..results demonstrated that the endogenous IRFs bound to the ISRE are complexed with the histone acetylases, PCAF, GCN5, and p300/CREB binding protein and that histone acetylase activities are accumulated on the IRF-ISRE complexes...
  63. Senyuk V, Sinha K, Chakraborty S, Buonamici S, Nucifora G. P/CAF and GCN5 acetylate the AML1/MDS1/EVI1 fusion oncoprotein. Biochem Biophys Res Commun. 2003;307:980-6 pubmed
    ..produced by the t(3;21) associated with human leukemia, physically interacts with the acetyltransferases P/CAF and GCN5. Our data suggest that AME has at least two binding sites for these acetyltransferases, one of which is in the Runt ..
  64. Rodrigue Way A, Caron V, Bilodeau S, Keil S, Hassan M, Levy E, et al. Scavenger receptor CD36 mediates inhibition of cholesterol synthesis via activation of the PPAR?/PGC-1? pathway and Insig1/2 expression in hepatocytes. FASEB J. 2014;28:1910-23 pubmed publisher
    ..Our data identify CD36 as a novel regulator of HMG-CoA reductase function and Insig-1/2 expression, 2 critical steps regulating cholesterol synthesis in hepatocytes. ..
  65. Andrews P, Kao K. Wnt/?-catenin-dependent acetylation of Pygo2 by CBP/p300 histone acetyltransferase family members. Biochem J. 2016;473:4193-4203 pubmed
    ..The HAT CBP/p300, but not GCN5/PCAF, targeted specific lysine residues of the N-terminal homology domain of Pygo2 for acetylation...
  66. Zhou S, Jiang W, Long F, Cheng S, Yang W, Zhao Y, et al. Rice Homeodomain Protein WOX11 Recruits a Histone Acetyltransferase Complex to Establish Programs of Cell Proliferation of Crown Root Meristem. Plant Cell. 2017;29:1088-1104 pubmed publisher
    ..Here, we show that WOX11 recruits the ADA2-GCN5 histone acetyltransferase module to activate downstream target genes in crown root meristem...
  67. Faiola F, Liu X, Lo S, Pan S, Zhang K, Lymar E, et al. Dual regulation of c-Myc by p300 via acetylation-dependent control of Myc protein turnover and coactivation of Myc-induced transcription. Mol Cell Biol. 2005;25:10220-34 pubmed
    ..activation domain (TAD) that recruits cofactor complexes containing the histone acetyltransferases (HATs) GCN5 and Tip60...
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    ..We report here that GCN5, a histone acetyltransferase, associates with COMMD1 and other components of the ligase, promotes RelA ..
  69. Kamieniarz K, Izzo A, Dundr M, Tropberger P, Ozretić L, Kirfel J, et al. A dual role of linker histone H1.4 Lys 34 acetylation in transcriptional activation. Genes Dev. 2012;26:797-802 pubmed publisher
    ..We show that H1.4K34 acetylation (H1.4K34ac) is mediated by GCN5 and is preferentially enriched at promoters of active genes, where it stimulates transcription by increasing H1 ..
  70. Holmlund T, Lindberg M, Grander D, Wallberg A. GCN5 acetylates and regulates the stability of the oncoprotein E2A-PBX1 in acute lymphoblastic leukemia. Leukemia. 2013;27:578-85 pubmed publisher
    ..STAGA, and its acetyltransferase subunit GCN5, directly interacted with the E2A portion of E2A-PBX1...
  71. Caliskan G, Baris I, Ayaydin F, Dobson M, Senarisoy M, Boros I, et al. Che1/AATF interacts with subunits of the histone acetyltransferase core module of SAGA complexes. PLoS ONE. 2017;12:e0189193 pubmed publisher
    General Control Non-derepressible 5 (GCN5) and Alteration/Deficiency in Activation 2 and 3 proteins (ADA2 and ADA3, respectively) are subunits of the Histone AcetylTransferase (HAT) module of SAGA- and ATAC-type co-activators...
  72. Li D, Urs A, Allegood J, Leon A, Merrill A, Sewer M. Cyclic AMP-stimulated interaction between steroidogenic factor 1 and diacylglycerol kinase theta facilitates induction of CYP17. Mol Cell Biol. 2007;27:6669-85 pubmed
    ..We conclude that ACTH/cAMP stimulates PA production in the nucleus of H295R cells and that this increase in PA concentrations facilitates CYP17 induction. ..
  73. Kuo Y, Andrews A. Quantitating the specificity and selectivity of Gcn5-mediated acetylation of histone H3. PLoS ONE. 2013;8:e54896 pubmed publisher
    ..KATs such as Gcn5 and p300/CBP can modify multiple residues on a single histone; however, order and specificity of acetylation can be ..
  74. Jeitany M, Bakhos Douaihy D, Silvestre D, Pineda J, Ugolin N, Moussa A, et al. Opposite effects of GCN5 and PCAF knockdowns on the alternative mechanism of telomere maintenance. Oncotarget. 2017;8:26269-26280 pubmed publisher
    ..General control non-derepressible 5 (GCN5) and P300/CBP-associated factor (PCAF) are two homologous acetyltransferases that are mutually exclusive subunits ..
  75. Båvner A, Johansson L, Toresson G, Gustafsson J, Treuter E. A transcriptional inhibitor targeted by the atypical orphan nuclear receptor SHP. EMBO Rep. 2002;3:478-84 pubmed
    ..We suggest histone acetyltransferases and histones as targets for EID1 action and propose that SHP inhibition of transcription involves EID1 antagonism of CBP/p300-dependent coactivator functions. ..
  76. Guelman S, Kozuka K, Mao Y, Pham V, Solloway M, Wang J, et al. The double-histone-acetyltransferase complex ATAC is essential for mammalian development. Mol Cell Biol. 2009;29:1176-88 pubmed publisher
    ..Here we report the characterization of a novel mammalian HAT complex, which contains the two acetyltransferases GCN5 and ATAC2 as well as other proteins linked to chromatin metabolism...
  77. Riss A, Scheer E, Joint M, Trowitzsch S, Berger I, Tora L. Subunits of ADA-two-A-containing (ATAC) or Spt-Ada-Gcn5-acetyltrasferase (SAGA) Coactivator Complexes Enhance the Acetyltransferase Activity of GCN5. J Biol Chem. 2015;290:28997-9009 pubmed publisher
    ..GCN5 (KAT2A) is a member of the GNAT (Gcn5-related N-acetyltransferase) family of HATs...
  78. Tavares C, Sharabi K, Dominy J, Lee Y, Isasa M, Orozco J, et al. The Methionine Transamination Pathway Controls Hepatic Glucose Metabolism through Regulation of the GCN5 Acetyltransferase and the PGC-1α Transcriptional Coactivator. J Biol Chem. 2016;291:10635-45 pubmed publisher
    ..Here, we show that methionine and derived-sulfur metabolites in the transamination pathway activate the GCN5 acetyltransferase promoting acetylation of the transcriptional coactivator PGC-1α to control hepatic ..
  79. Pryjma M, Burian J, Kuchinski K, Thompson C. Antagonism between Front-Line Antibiotics Clarithromycin and Amikacin in the Treatment of Mycobacterium abscessus Infections Is Mediated by the whiB7 Gene. Antimicrob Agents Chemother. 2017;61: pubmed publisher
    ..The whiB7-dependent gene contributing to amikacin resistance was eis2 (MAB_4532c), which encodes a Gcn5-related N-acetyltransferase (GNAT)...
  80. Carter K, Wang L, Shell B, Zamir I, Berger S, Moore P. The human transcriptional adaptor genes TADA2L and GCN5L2 colocalize to chromosome 17q12-q21 and display a similar tissue expression pattern. Genomics. 1997;40:497-500 pubmed
    The chromosomal locations and the tissue expression patterns of the human transcriptional adaptors TADA2L and GCN5L2 have been determined...
  81. Smith E, Belote J, Schiltz R, Yang X, Moore P, Berger S, et al. Cloning of Drosophila GCN5: conserved features among metazoan GCN5 family members. Nucleic Acids Res. 1998;26:2948-54 pubmed
    PCAF and hGCN5 are distinct human genes that encode proteins related to the yeast histone acetyltransferase and transcriptional adapter GCN5...
  82. Kurooka H, Honjo T. Functional interaction between the mouse notch1 intracellular region and histone acetyltransferases PCAF and GCN5. J Biol Chem. 2000;275:17211-20 pubmed
    ..Here we show that mouse Notch1 RAMIC interacts with two conserved HATs, mouse PCAF and GCN5, and recruits each of the HATs to RBP-J...
  83. Rodolosse A, Campos M, Rooman I, Lichtenstein M, Real F. p/CAF modulates the activity of the transcription factor p48/Ptf1a involved in pancreatic acinar differentiation. Biochem J. 2009;418:463-73 pubmed publisher
    ..In contrast, p/CAF did not co-operate with p48 in its growth regulatory effects. These results support a critical and selective role of p/CAF in PTF1-dependent gene activation during acinar differentiation. ..
  84. Rice A. The HIV-1 Tat team gets bigger. Cell Host Microbe. 2010;7:179-81 pubmed publisher
    ..Now, Pagans and colleagues report that the lysine methyltransferase Set7/9-KMT7 associates with Tat to stimulate RNA polymerase II elongation of the integrated provirus. Set7/9-KMT7 also methylates Tat, and this enhances Tat function. ..
  85. Takenaka S, Ozeki T, Tanaka K, Yoshida K. Homology modeling and prediction of the amino acid residues participating in the transfer of acetyl-CoA to arylalkylamine by the N-acetyltransferase from Chryseobacterium sp. Biotechnol Lett. 2017;39:1699-1707 pubmed publisher
    ..structure of this compound with the structures of previously reported proteins belonging to the bacterial GCN5 N-acetyltransferase family...
  86. Poux A, Cebrat M, Kim C, Cole P, Marmorstein R. Structure of the GCN5 histone acetyltransferase bound to a bisubstrate inhibitor. Proc Natl Acad Sci U S A. 2002;99:14065-70 pubmed
    ..with distinct specificities for the p300/CBP [cAMP response element binding protein (CREB)-binding protein] or GCN5 HAT subfamilies...
  87. Zheng Y, Yao X. Posttranslational modifications of HIV-1 integrase by various cellular proteins during viral replication. Viruses. 2013;5:1787-801 pubmed publisher
    ..Here, we review the advances in the understanding of the mechanisms and roles of multiple IN PTMs...
  88. Wang L, Dent S. Functions of SAGA in development and disease. Epigenomics. 2014;6:329-39 pubmed publisher
    ..embryo development requires cooperation between transcriptional factors and histone-modifying enzymes, such as the Gcn5 histone acetyltransferase...
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    ..Here, we identify general control nonderepressible 5 (GCN5), a HAT with 73% identity to PCAF, as a novel XBP-1S regulator...
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    ..Together, our findings reveal lysine acetyltransfer to be a potential regulator of platelet actin dynamics, and potential roles for lysine acetylation in the molecular coordination of platelet activation and function. ..
  91. Liu K, Zhang Q, Lan H, Wang L, Mou P, Shao W, et al. GCN5 Potentiates Glioma Proliferation and Invasion via STAT3 and AKT Signaling Pathways. Int J Mol Sci. 2015;16:21897-910 pubmed publisher
    The general control of nucleotide synthesis 5 (GCN5), which is one kind of lysine acetyltransferases, regulates a number of cellular processes, such as cell proliferation, differentiation, cell cycle and DNA damage repair...
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