Gene Symbol: JunD
Description: JunD proto-oncogene, AP-1 transcription factor subunit
Alias: AP-1, transcription factor jun-D, JunD-FL isoform, activator protein 1, jun D proto-oncogene
Species: human
Products:     JunD

Top Publications

  1. Vasanwala F, Kusam S, Toney L, Dent A. Repression of AP-1 function: a mechanism for the regulation of Blimp-1 expression and B lymphocyte differentiation by the B cell lymphoma-6 protooncogene. J Immunol. 2002;169:1922-9 pubmed
    ..We found that the zinc-finger region of BCL-6 interacts with c-Jun, JunB, and JunD proteins but does not bind c-Fos or Fra-2 proteins...
  2. Bianchi E, Denti S, Catena R, Rossetti G, Polo S, Gasparian S, et al. Characterization of human constitutive photomorphogenesis protein 1, a RING finger ubiquitin ligase that interacts with Jun transcription factors and modulates their transcriptional activity. J Biol Chem. 2003;278:19682-90 pubmed
    ..Our findings indicate that huCOP1 is a novel regulator of AP-1-dependent transcription sharing the important properties of Arabidopsis COP1 in the control of gene expression. ..
  3. Thebault S, Basbous J, Hivin P, Devaux C, Mesnard J. HBZ interacts with JunD and stimulates its transcriptional activity. FEBS Lett. 2004;562:165-70 pubmed
    ..Here we show that HBZ also interacts with JunD in vitro and in vivo, and that this association occurs via the bZIP domain of the two proteins...
  4. Berger I, Shaul Y. Structure and function of human jun-D. Oncogene. 1991;6:561-6 pubmed
    ..Interestingly, at high concentrations human jun-D displays decreased activity which cannot be explained by a simple self squelching model. ..
  5. Ansari R, Husain K, Rizvi S. Role of Transcription Factors in Steatohepatitis and Hypertension after Ethanol: The Epicenter of Metabolism. Biomolecules. 2016;6: pubmed publisher
    ..In addition to these transcription factors, activator protein-1 may also be activated in hepatocytes due to its association with resolution of increased ROS. These transcription factors are central to alcohol-mediated hepatotoxicity. ..
  6. Hałatek T, Stanisławska M, Swiercz R, Domeradzka Gajda K, Kuras R, Wasowicz W. Clara cells protein, prolactin and transcription factors of protein NF-ĸB and c-Jun/AP-1 levels in rats inhaled to stainless steel welding dust and its soluble form. Int J Occup Med Environ Health. 2018;31:613-632 pubmed publisher
    ..cells secretory protein relation with prolactin in exposed rats to welding dust were shown and explored whether the NF-κB and c-Jun/activator protein 1 related pathway was involved. Int J Occup Med Environ Health 2018;31(5):613-632.
  7. Hong Y, Lee H, Jung B, Jang S, Chung D, Kim H. Lipoteichoic acid isolated from Lactobacillus plantarum down-regulates UV-induced MMP-1 expression and up-regulates type I procollagen through the inhibition of reactive oxygen species generation. Mol Immunol. 2015;67:248-55 pubmed publisher
    ..Therefore, pLTA from L. plantarum has potential abilities to prevent and treat skin photo-aging. ..
  8. Yuan R, Huang L, Du L, Feng J, Li J, Luo Y, et al. Dihydrotanshinone exhibits an anti-inflammatory effect in vitro and in vivo through blocking TLR4 dimerization. Pharmacol Res. 2019;142:102-114 pubmed publisher
    ..Taken together, our results indicated that DHT exhibited significant anti-inflammatory activity both in vitro and in vivo, suggesting that DHT may be a potential therapeutic agent for inflammatory diseases. ..
  9. Zhang Y, Guo H, Cheng B, Su T, Fu X, Li T, et al. Dingchuan tang essential oil inhibits the production of inflammatory mediators via suppressing the IRAK/NF-κB, IRAK/AP-1, and TBK1/IRF3 pathways in lipopolysaccharide-stimulated RAW264.7 cells. Drug Des Devel Ther. 2018;12:2731-2748 pubmed publisher
    ..7 macrophages. This study provides a pharmacological justification for the use of dingchuan tang in managing inflammatory disorders. ..

More Information

Publications149 found, 100 shown here

  1. Sárközy M, Szucs G, Fekete V, Pipicz M, Eder K, Gáspár R, et al. Transcriptomic alterations in the heart of non-obese type 2 diabetic Goto-Kakizaki rats. Cardiovasc Diabetol. 2016;15:110 pubmed publisher
    ..g. Tnni1, Mylk2, Col8a1, Adam33), cell growth and differentiation (e.g. Gpc3, Jund), immune response (e.g. C3, C4a), and others (e.g. Lrp8, Msln, Klkc1, Epn3)...
  2. Lyu D, Tang N, Wang J, Zhang Y, Chang J, Liu Z, et al. TGR5 agonist INT-777 mitigates inflammatory response in human endometriotic stromal cells: A therapeutic implication for endometriosis. Int Immunopharmacol. 2019;71:93-99 pubmed publisher
    ..Therefore, INT-777 may have an implication in the clinical treatment of endometriosis. ..
  3. Engin A. The Pathogenesis of Obesity-Associated Adipose Tissue Inflammation. Adv Exp Med Biol. 2017;960:221-245 pubmed publisher
    ..UPR) due to endoplasmic reticulum (ER) stress through hyperactivation of c-Jun N-terminal Kinase (JNK) -Activator Protein 1 (AP1) and inhibitor of nuclear factor kappa-B kinase beta (IKKbeta)-nuclear factor kappa B (NF-kappaB) ..
  4. Lee J, Chang C, Sheu J, Jayakumar T. Pharmacology and Clinical Effect of Platonin, a Cyanine Photosensitizing Dye: Potential Molecular Targets. Curr Pharm Biotechnol. 2014;15:700-11 pubmed
  5. Zhao X, Xu Z, Wang Z, Wu Z, Gong Y, Zhou L, et al. RNA silencing of integrin-linked kinase increases the sensitivity of the A549 lung cancer cell line to cisplatin and promotes its apoptosis. Mol Med Rep. 2015;12:960-6 pubmed publisher
    ..ILK inhibition may suppress the proliferation of A549 and increase A549 sensitivity to cisplatin. The combined treatment of ILK gene knockdown and chemotherapy has the potential to improve anticancer efficacy. ..
  6. Petronilho F, Vuolo F, Galant L, Constantino L, Tomasi C, Giombelli V, et al. Gastrin-releasing peptide receptor antagonism induces protection from lethal sepsis: involvement of toll-like receptor 4 signaling. Mol Med. 2012;18:1209-19 pubmed publisher
    ..kinase (ERK)-1/2, Jun NH(2)-terminal kinase (JNK) and Akt and decreased activation of activator protein 1 (AP-1), nuclear factor (NF)-?B and interleukin (IL)-6 in macrophages stimulated by LPS...
  7. Purohit V, Rapaka R, Kwon O, Song B. Roles of alcohol and tobacco exposure in the development of hepatocellular carcinoma. Life Sci. 2013;92:3-9 pubmed publisher
    ..Simultaneous exposure to alcohol and tobacco is expected to promote the development of HCC in an additive and/or synergistic manner. ..
  8. Maines M. Potential application of biliverdin reductase and its fragments to modulate insulin/IGF-1/MAPK/PI3-K signaling pathways in therapeutic settings. Curr Drug Targets. 2010;11:1586-94 pubmed
    ..This, points to a realistic prospect of their use in clinical settings. The present review will briefly update cytoprotective activity and cytotoxicity of bile pigments and will focus on findings that link hBVR to cell signaling. ..
  9. Gawryluk J, Young L. Signal transduction pathways in the pathophysiology of bipolar disorder. Curr Top Behav Neurosci. 2011;5:139-65 pubmed publisher
    ..The influence of mood stabilizers on transcription factors may be important in connecting the regulation of gene expression to neuroplasticity and cellular resilience. ..
  10. Rana A, Singh D. Targeting glycogen synthase kinase-3 for oxidative stress and neuroinflammation: Opportunities, challenges and future directions for cerebral stroke management. Neuropharmacology. 2018;139:124-136 pubmed publisher
    ..also modulates the expression of anti-inflammatory protein like, cAMP response element binding protein and activator protein 1. It has been found that the inhibition of Gsk-3 shows neuroprotection via reducing the oxidative stress and ..
  11. Watson R, Schönlau F. Nutraceutical and antioxidant effects of a delphinidin-rich maqui berry extract Delphinol®: a review. Minerva Cardioangiol. 2015;63:1-12 pubmed
    ..Future research on Delphinol® and delphinidins may be expected to identify further health benefits. ..
  12. Newby A. Metalloproteinase production from macrophages - a perfect storm leading to atherosclerotic plaque rupture and myocardial infarction. Exp Physiol. 2016;101:1327-1337 pubmed publisher
    ..A 'perfect storm' caused by a combination of these mechanisms is most likely to promote MMP-mediated macrophage invasion, tissue destruction and atherosclerotic plaque rupture. ..
  13. Kloos B, Chakraborty S, Lindner S, Noack K, Harre U, Schett G, et al. Pasteurella multocida toxin- induced osteoclastogenesis requires mTOR activation. Cell Commun Signal. 2015;13:40 pubmed publisher
    ..Ultimately this results in the activation of c-Jun, a component of the activator protein 1 (AP-1) complex, which is a major transcription factor for the induction of osteoclast-specific genes...
  14. Liu T, Li L, Zhang F, Wang Y. Transcriptional inhibition of the Catalase gene in phosphine-induced oxidative stress in Drosophila melanogaster. Pestic Biochem Physiol. 2015;124:1-7 pubmed publisher
    ..These results confirmed that PH3 induces oxidative stress and targets CAT by downregulating its encoding gene in Drosophila. Our results provide new insight into the signal transduction mechanism between PH3 and its target genes. ..
  15. Veach R, Liu Y, Zienkiewicz J, Wylezinski L, Boyd K, Wynn J, et al. Survival, bacterial clearance and thrombocytopenia are improved in polymicrobial sepsis by targeting nuclear transport shuttles. PLoS ONE. 2017;12:e0179468 pubmed publisher
    ..transcription factors nuclear factor kappa B, signal transducer and activator of transcription 1 alpha, and activator protein 1 in liver, which was also protected from sepsis-associated metabolic changes...
  16. Faid I, Al Hussaini H, Kilarkaje N. Resveratrol alleviates diabetes-induced testicular dysfunction by inhibiting oxidative stress and c-Jun N-terminal kinase signaling in rats. Toxicol Appl Pharmacol. 2015;289:482-94 pubmed publisher
    ..These results suggest that Resveratrol supplementation may be a useful strategy to treat diabetes-induced testicular dysfunction. ..
  17. Zheng L, Xing L, Zeng C, Wu T, Gui Y, Li W, et al. Inactivation of PI3Kδ induces vascular injury and promotes aneurysm development by upregulating the AP-1/MMP-12 pathway in macrophages. Arterioscler Thromb Vasc Biol. 2015;35:368-77 pubmed publisher
  18. Kim J, Yenari M, Lee J. Regulation of inflammatory transcription factors by heat shock protein 70 in primary cultured astrocytes exposed to oxygen-glucose deprivation. Neuroscience. 2015;286:272-80 pubmed publisher
    ..Taken together, these results suggest that overexpression of Hsp70 may protect against brain ischemia via an anti-inflammatory mechanism by interrupting the phosphorylation of upstream of transcription factors. ..
  19. Sharma P, Panebra A, Pera T, Tiegs B, Hershfeld A, Kenyon L, et al. Antimitogenic effect of bitter taste receptor agonists on airway smooth muscle cells. Am J Physiol Lung Cell Mol Physiol. 2016;310:L365-76 pubmed publisher
  20. Piao M, Kang K, Zhen A, Kang H, Koh Y, Kim B, et al. Horse Oil Mitigates Oxidative Damage to Human HaCaT Keratinocytes Caused by Ultraviolet B Irradiation. Int J Mol Sci. 2019;20: pubmed publisher
    ..Additionally, horse oil reduced UVB-induced binding of activator protein 1 to the matrix metalloproteinase-1 promoter site...
  21. Rhee J, Park S, Kim S, Kim J, Ha C, Chun C, et al. Inhibition of BATF/JUN transcriptional activity protects against osteoarthritic cartilage destruction. Ann Rheum Dis. 2017;76:427-434 pubmed publisher
    ..Our findings collectively support the utility of BATF as a therapeutic target for OA. ..
  22. Xu B, Luo Y, Liu Y, Li B, Wang Y. Platelet-derived growth factor-BB enhances MSC-mediated cardioprotection via suppression of miR-320 expression. Am J Physiol Heart Circ Physiol. 2015;308:H980-9 pubmed publisher
    ..Collectively, we conclude that PDGF enhances MSC-mediated cardioprotection via a c-Jun/miR-320 signaling mechanism and PDGF MSC preconditioning may be an effective therapeutic strategy for cardiac ischemia. ..
  23. Alvarado D, Hawkins R, Bashiardes S, Veile R, Ku Y, Powder K, et al. An RNA interference-based screen of transcription factor genes identifies pathways necessary for sensory regeneration in the avian inner ear. J Neurosci. 2011;31:4535-43 pubmed publisher
    ..Among the required genes, the CCAAT enhancer binding protein, CEBPG, acts downstream of Jun Kinase and JUND in the AP1 pathway. The WNT coreceptor LRP5 acts downstream of CEBPG, as does the transcription factor BTAF1...
  24. Debnath M, Agrawal S, Agrawal A, Dubey G. Metaflammatory responses during obesity: Pathomechanism and treatment. Obes Res Clin Pract. 2016;10:103-13 pubmed publisher
    ..Anti-inflammatory treatment so as to curb the severity of inflammatory responses includes administration of synthetic drugs to target the actual inflammatory molecules and various therapeutic interventions. ..
  25. El Salhy M, Umezawa K. Treatment with novel AP-1 and NF-κB inhibitors restores the colonic endocrine cells to normal levels in rats with DSS-induced colitis. Int J Mol Med. 2016;37:556-64 pubmed publisher
    ..rats were treated with 3-[(dodecylthiocarbonyl)‑methyl]‑glutarimide (DTCM‑G), a novel activator protein 1 (AP-1) inhibitor, 20 mg/kg in CMC; and iii) DSS‑Q group, rats were treated with ..
  26. Ishikawa C, Senba M, Mori N. Mitotic kinase PBK/TOPK as a therapeutic target for adult T‑cell leukemia/lymphoma. Int J Oncol. 2018;53:801-814 pubmed publisher
    ..IKKβ, IκBα, phosphatase and tensin homolog (PTEN) and Akt, and to the decreased protein expression of JunB and JunD, suggesting that PBK/TOPK affects the nuclear factor-κB, Akt and activator protein‑1 signaling pathways...
  27. Yang C, Lin C, Hsieh H. High-Glucose-Derived Oxidative Stress-Dependent Heme Oxygenase-1 Expression from Astrocytes Contributes to the Neuronal Apoptosis. Mol Neurobiol. 2017;54:470-483 pubmed publisher
    ..JNK) and then activated the downstream transcriptional factors nuclear factor-kappaB (NF-κB) and c-Fos/activator protein 1 (AP-1), respectively. Subsequently, the activated NF-κB and AP-1 turned on transcription of HO-1 gene...
  28. Chen S, Chen P, Wu Y, Chen C, Chen H, Lii C, et al. Long-chain polyunsaturated fatty acids amend palmitate-induced inflammation and insulin resistance in mouse C2C12 myotubes. Food Funct. 2016;7:270-8 pubmed publisher
    ..In addition to the NF-κB pathway, other mechanisms are involved in the health benefits of DHA and EPA in PA-treated myotubes. ..
  29. Ganti K, Mukherji A, Surjit M, Li M, Chambon P. Similarities and differences in the transcriptional control of expression of the mouse TSLP gene in skin epidermis and intestinal epithelium. Proc Natl Acad Sci U S A. 2017;114:E951-E960 pubmed publisher
    ..Furthermore, we identified several functional NF-κB, activator protein 1 (AP1), STAT, and Smad DBS in the TSLP promoter region...
  30. Dey I, Bradbury N. Activation of TPA-response element present in human Lemur Tyrosine Kinase 2 (lmtk2) gene increases its expression. Biochem Biophys Rep. 2017;12:140-150 pubmed publisher
    ..Considering the involvement of LMTK2 in intracellular processes as well as pathological conditions, our findings demonstrate a way to modulate intracellular LMTK2 levels pharmacologically for potentially therapeutic purposes...
  31. Bhattarai G, Kook S, Kim J, Poudel S, Lim S, Seo Y, et al. COMP-Ang1 prevents periodontitic damages and enhances mandible bone growth in an experimental animal model. Bone. 2016;92:168-179 pubmed publisher
    ..Collectively, our findings may support the therapeutic potentials of COMP-Ang1 in preventing inflammatory periodontal damages and in stimulating new bone growth. ..
  32. Lee H, Shin J, Lee W, Ryu B, Jang D, Lee K. Biflorin, Isolated from the Flower Buds of Syzygium aromaticum L., Suppresses LPS-Induced Inflammatory Mediators via STAT1 Inactivation in Macrophages and Protects Mice from Endotoxin Shock. J Nat Prod. 2016;79:711-20 pubmed publisher
    ..did not affect the activity of nuclear factor κ light-chain enhancer of activated B cells (NF-κB) or activator protein 1 (AP-1)...
  33. Liu C, Ren J, Liu P. Amphetamine manipulates monoamine oxidase-A level and behavior using theranostic aptamers of transcription factors AP-1/NF-kB. J Biomed Sci. 2016;23:21 pubmed publisher
    ..This study has implications for design for the treatment of drug exposure and perhaps Parkinson's dementia. ..
  34. Halder K, Banerjee S, Ghosh S, Bose A, Das S, Chowdhury B, et al. Mycobacterium indicus pranii (Mw) inhibits invasion by reducing matrix metalloproteinase (MMP-9) via AKT/ERK-1/2 and PKC? signaling: A potential candidate in melanoma cancer therapy. Cancer Biol Ther. 2017;18:850-862 pubmed publisher
  35. Zheng B, Wen Z, Huang Y, Xia M, Xiang X, Qu Y. Molecular Weight-Dependent Immunostimulative Activity of Low Molecular Weight Chitosan via Regulating NF-?B and AP-1 Signaling Pathways in RAW264.7 Macrophages. Mar Drugs. 2016;14: pubmed
    ..7 macrophages in a molecular weight-dependent manner and that 3 kDa LMWC shows great potential as a novel agent for the treatment of immune suppression diseases and in future vaccines. ..
  36. Wang P, Luan J, Xu W, Wang L, Xu D, Yang C, et al. Astragaloside IV downregulates the expression of MDR1 in Bel‑7402/FU human hepatic cancer cells by inhibiting the JNK/c‑Jun/AP‑1 signaling pathway. Mol Med Rep. 2017;16:2761-2766 pubmed publisher
    ..Taken together, these results indicated that ASIV reversed the drug resistance of Bel‑7402/FU cells by downregulating the expression of mdr1 via inhibition of the JNK/c‑Jun/AP‑1 signaling pathway. ..
  37. Pedro de Magalhães J, Thompson L, de Lima I, Gaskill D, Li X, Thornton D, et al. A Reassessment of Genes Modulating Aging in Mice Using Demographic Measurements of the Rate of Aging. Genetics. 2018;208:1617-1630 pubmed publisher
    ..features, we found evidence of five accelerating demographic aging: Casp2, Fn1, IKK-?, JunD, and Stub1 Overall, our reassessment found that only 15% of the genetic manipulations analyzed ..
  38. Kim H, Lee J, Kim B, Cho E, Kim S, Youn H. Menin represses JunD transcriptional activity in protein kinase C theta-mediated Nur77 expression. Exp Mol Med. 2005;37:466-75 pubmed
    ..Herein, we report that PKCtheta targets AP-1 like response element in the Nur77 promoter where JunD constitutively binds...
  39. Lei K, Georgiou E, Chen L, Yulia A, Sooranna S, Brosens J, et al. Progesterone and the Repression of Myometrial Inflammation: The Roles of MKP-1 and the AP-1 System. Mol Endocrinol. 2015;29:1454-67 pubmed publisher
    ..Taken together, the data show that P4 acts via GR to drive MKP-1 expression, which in turn inhibits IL-1β-dependent c-Jun activation and COX-2 expression. ..
  40. Matsuzaki H, Mikami Y, Makita K, Takeshima H, Horie M, Noguchi S, et al. Interleukin-17A and Toll-Like Receptor 3 Ligand Poly(I:C) Synergistically Induced Neutrophil Chemoattractant Production by Bronchial Epithelial Cells. PLoS ONE. 2015;10:e0141746 pubmed publisher
    ..factor-κB translocation into the nucleus or the transcriptional activities of nuclear factor-κB and activator protein 1. IL-17A promoted stabilization of CXCL8 mRNA in BEAS-2B cells treated with poly(I:C)...
  41. Zhang Y, Xiang Y. Molecular and cellular basis for the unique functioning of Nrf1, an indispensable transcription factor for maintaining cell homoeostasis and organ integrity. Biochem J. 2016;473:961-1000 pubmed publisher
    ..g. sMaf, c-Jun, JunD or c-Fos), to regulate different sets of cognate genes...
  42. Meili N, Christen V, Fent K. Nodularin induces tumor necrosis factor-alpha and mitogen-activated protein kinases (MAPK) and leads to induction of endoplasmic reticulum stress. Toxicol Appl Pharmacol. 2016;300:25-33 pubmed publisher
    ..All of these activated pathways, which were analysed here for the first time in detail, may contribute to the hepatotoxic, and tumorigenic action of nodularin. ..
  43. Roh K, Kim H, Shin S, Kim Y, Lee J, Kim M, et al. Anti-inflammatory effects of Zea mays L. husk extracts. BMC Complement Altern Med. 2016;16:298 pubmed publisher
    ..Our results indicate that ZMHE has anti-inflammatory effects by downregulating the expression of iNOS gene and its downregulation is mediated by inhibiting NF-kB and AP-1 signaling. ..
  44. Hsu F, Chiang M, Li F, Yeh C, Lee W, Chau L. Acetylation is essential for nuclear heme oxygenase-1-enhanced tumor growth and invasiveness. Oncogene. 2017;36:6805-6814 pubmed publisher
    ..Mechanistic studies demonstrated that transcriptional factor JunD interacted with wild-type (WT) t-HO-1 and mutant carrying K243/256Q but not K243/256 R mutation...
  45. Subramanian D, Bunjobpol W, Sabapathy K. Interplay between TAp73 Protein and Selected Activator Protein-1 (AP-1) Family Members Promotes AP-1 Target Gene Activation and Cellular Growth. J Biol Chem. 2015;290:18636-49 pubmed publisher
  46. Sha X, Meng S, Li X, Xi H, Maddaloni M, Pascual D, et al. Interleukin-35 Inhibits Endothelial Cell Activation by Suppressing MAPK-AP-1 Pathway. J Biol Chem. 2015;290:19307-18 pubmed publisher
    ..Our results provide insight into the control of vascular inflammation by IL-35 and suggest that IL-35 is an attractive novel therapeutic reagent for sepsis and cardiovascular diseases. ..
  47. Li T, He X, Jia H, Chen G, Zeng S, Fang Y, et al. Molecular cloning and functional characterization of murine toll‑like receptor 8. Mol Med Rep. 2016;13:1119-26 pubmed publisher
    ..However, mTLR8 is not able to activate interferon regulatory factor 3 or activator protein 1, nor can it induce interferon-α in HEK293T cells...
  48. Sun X, Deng Q, Liang Z, Zhang Z, Zhao L, Geng H, et al. Curcumin reverses benzidine-induced cell proliferation by suppressing ERK1/2 pathway in human bladder cancer T24 cells. Exp Toxicol Pathol. 2016;68:215-22 pubmed publisher
    ..resulted in activation of extracellular regulated protein kinases 1 and 2 (ERK1/2) pathway as well as activator protein 1 (AP-1) proteins...
  49. Sheikh A, Takatori A, Hossain M, Hasan M, Tagawa M, Nagase H, et al. Unfavorable neuroblastoma prognostic factor NLRR2 inhibits cell differentiation by transcriptional induction through JNK pathway. Cancer Sci. 2016;107:1223-32 pubmed publisher
    ..Therefore, NLRR2 should have an important role in NB aggressiveness and be a potential therapeutic target for the treatment of RA resistant and aggressive NB. ..
  50. Wang W, Wang Y, Debing Y, Zhou X, Yin Y, Xu L, et al. Biological or pharmacological activation of protein kinase C alpha constrains hepatitis E virus replication. Antiviral Res. 2017;140:1-12 pubmed publisher
    ..Interestingly, upon the stimulation by its activator, PKCα efficiently activates its downstream Activator Protein 1 (AP-1) pathway, leading to the induction of antiviral interferon-stimulated genes (ISGs)...
  51. Trop Steinberg S, Azar Y. AP-1 Expression and its Clinical Relevance in Immune Disorders and Cancer. Am J Med Sci. 2017;353:474-483 pubmed publisher
    ..We review current knowledge regarding the functions of activator protein 1 (AP-1) as an important modulator in several immune disorders and carcinomas...
  52. Nakatani T, Partridge N. MEF2C Interacts With c-FOS in PTH-Stimulated Mmp13 Gene Expression in Osteoblastic Cells. Endocrinology. 2017;158:3778-3791 pubmed publisher
    ..The observation of MEF2C interacting with a member of the AP-1 transcription factor family provides knowledge of the functions of HDAC4, c-FOS, and MEF2C. ..
  53. Zerbini L, Wang Y, Cho J, Libermann T. Constitutive activation of nuclear factor kappaB p50/p65 and Fra-1 and JunD is essential for deregulated interleukin 6 expression in prostate cancer. Cancer Res. 2003;63:2206-15 pubmed
    ..part mediated by a combined constitutive activation of the nuclear factor (NF)-kappaB p50 and p65 and the activator protein 1 (AP-1) JunD and Fra-1 family members as demonstrated by electrophoretic mobility shift assays, site-..
  54. Li C, Li S, Kong D, Meng X, Zong Z, Liu B, et al. BAG3 is upregulated by c-Jun and stabilizes JunD. Biochim Biophys Acta. 2013;1833:3346-3354 pubmed publisher
    ..In addition, the current study reported that BAG3 stabilized JunD mRNA, which was, at least in part, responsible for the promotion of serum starvation mediated-growth inhibition by ..
  55. Singh A, Singh V, Tiwari R, Chandra T, Kumar A, Dikshit M, et al. The IRAK-ERK-p67phox-Nox-2 axis mediates TLR4, 2-induced ROS production for IL-1? transcription and processing in monocytes. Cell Mol Immunol. 2016;13:745-763 pubmed publisher
    ..In the present study, we demonstrate that the TLR4- and TLR2-induced IRAK-ERK pathway cross-talks with p67phox-Nox-2 for ROS generation, thus regulating IL-1? transcription and processing in monocytic cells. ..
  56. Adamopoulos C, Piperi C, Gargalionis A, Dalagiorgou G, Spilioti E, Korkolopoulou P, et al. Advanced glycation end products upregulate lysyl oxidase and endothelin-1 in human aortic endothelial cells via parallel activation of ERK1/2-NF-κB and JNK-AP-1 signaling pathways. Cell Mol Life Sci. 2016;73:1685-98 pubmed publisher
  57. Sun J, Li C, Shen Z, Zhang W, Ai T, Du L, et al. Mineralocorticoid Receptor Deficiency in Macrophages Inhibits Neointimal Hyperplasia and Suppresses Macrophage Inflammation Through SGK1-AP1/NF-?B Pathways. Arterioscler Thromb Vasc Biol. 2016;36:874-85 pubmed publisher
    ..At the molecular level, MR deficiency suppresses macrophage inflammatory response via SGK1-AP1/NF-?B pathways. ..
  58. Chen M, Gan X, Yoshino K, Kitakawa M, Shoji I, Deng L, et al. Hepatitis C virus NS5A protein interacts with lysine methyltransferase SET and MYND domain-containing 3 and induces activator protein 1 activation. Microbiol Immunol. 2016;60:407-17 pubmed publisher
    ..Luciferase reporter assay demonstrated that NS5A significantly induces activator protein 1 (AP-1) activity, this being potentiated by co-expression of SMYD3 with NS5A...
  59. Brew O, Sullivan M. Oxygen and tissue culture affect placental gene expression. Placenta. 2017;55:13-20 pubmed publisher
    ..concentration, where further up-regulation of TFTs including PPARA, CEBPD, HOXA9 and down-regulated TFTs such as JUND/FOS suggest intrinsic heightened key biological and metabolic mechanisms such as glucose use, lipid biosynthesis, ..
  60. Hock T, Liby K, Wright M, McConnell S, Schorpp Kistner M, Ryan T, et al. JunB and JunD regulate human heme oxygenase-1 gene expression in renal epithelial cells. J Biol Chem. 2007;282:6875-86 pubmed
    ..JunB and JunD contribute opposing effects; JunB activated whereas JunD repressed heme oxygenase-1 expression in human renal ..
  61. Lee C, Cho H, Jeong Y, Shin J, Park K, Park Y, et al. Isothiocyanates inhibit the invasion and migration of C6 glioma cells by blocking FAK/JNK-mediated MMP-9 expression. Oncol Rep. 2015;34:2901-8 pubmed publisher
    ..These results suggest that ITCs could be potential agents for the prevention of C6 glioma cell migration and invasion by decreasing FAK/JNK-mediated MMP-9 expression. ..
  62. Son D, Hong J, Ban J, Park J, Lee H, Gu S, et al. Synergistic Inhibitory Effects of Cetuximab and Cisplatin on Human Colon Cancer Cell Growth via Inhibition of the ERK-Dependent EGF Receptor Signaling Pathway. Biomed Res Int. 2015;2015:397563 pubmed publisher
  63. Cai Y, Sukhova G, Wong H, Xu A, Tergaonkar V, Vanhoutte P, et al. Rap1 induces cytokine production in pro-inflammatory macrophages through NFκB signaling and is highly expressed in human atherosclerotic lesions. Cell Cycle. 2015;14:3580-92 pubmed publisher
    Repressor activator protein 1 (Rap1) is essential for maintaining telomere length and structural integrity, but it also exerts other non-telomeric functions...
  64. Song J, Piao M, Han X, Kang K, Kang H, Yoon W, et al. Anti-wrinkle effects of Sargassum muticum ethyl acetate fraction on ultraviolet B-irradiated hairless mouse skin and mechanistic evaluation in the human HaCaT keratinocyte cell line. Mol Med Rep. 2016;14:2937-44 pubmed publisher
    ..These results suggested that SME may be useful as an anti-photoaging resource for the skin. ..
  65. Nishad S, Ghosh A. Gene expression of immediate early genes of AP-1 transcription factor in human peripheral blood mononuclear cells in response to ionizing radiation. Radiat Environ Biophys. 2016;55:431-440 pubmed
    ..In this paper, coordinated transcript response of fos and jun family members which constitute activator protein 1 transcription factor was studied in response to IR in human peripheral blood lymphocytes at the G0
  66. Shandilya J, Gao Y, Nayak T, Roberts S, Medler K. AP1 transcription factors are required to maintain the peripheral taste system. Cell Death Dis. 2016;7:e2433 pubmed publisher
    ..Thus, AP1 factors are important regulators of adult taste cell renewal and their downregulation negatively impacts taste maintenance. ..
  67. Syed K, He X, Tillo D, Wang J, Durell S, Vinson C. 5-Methylcytosine (5mC) and 5-Hydroxymethylcytosine (5hmC) Enhance the DNA Binding of CREB1 to the C/EBP Half-Site Tetranucleotide GCAA. Biochemistry. 2016;55:6940-6948 pubmed
    ..one DNA strand on the double-stranded DNA binding of the mouse B-ZIP transcription factors (TFs) CREB1, ATF1, and JUND. 5mC inhibited binding of CREB1 to the canonical CRE half-site |GTCA but enhanced binding to the C/EBP half-site |..
  68. Shifrin H, Mouhadeb O, Gluck N, Varol C, Weinstock M. Cholinergic Anti-Inflammatory Pathway Does Not Contribute to Prevention of Ulcerative Colitis by Novel Indoline Carbamates. J Neuroimmune Pharmacol. 2017;12:484-491 pubmed publisher
    ..They prevent nuclear translocation of nuclear factor κB (NF-κB) and activator protein 1. Only AN917 inhibits cholinesterase (ChE) at relevant concentrations...
  69. Liang Z, Wu R, Xie W, Zhu M, Xie C, Li X, et al. Curcumin reverses tobacco smoke?induced epithelial?mesenchymal transition by suppressing the MAPK pathway in the lungs of mice. Mol Med Rep. 2017;: pubmed publisher
    ..The results of the present study provide new insights into the molecular mechanisms of tobacco smoke?associated lung cancer and may open up new avenues in the search for potential therapeutic targets in lung tumorigenesis...
  70. Karrys A, Rady I, Chamcheu R, Sabir M, Mallick S, Chamcheu J, et al. Bioactive Dietary VDR Ligands Regulate Genes Encoding Biomarkers of Skin Repair That Are Associated with Risk for Psoriasis. Nutrients. 2018;10: pubmed publisher
    ..These findings provide insights into the mechanism(s) whereby dietary VDR ligands alter inflammatory and barrier functions relevant to skin repair, and may provide a molecular basis for improved treatments for mild/moderate psoriasis. ..
  71. Sun X, Deng Q, Liang Z, Liu Z, Geng H, Zhao L, et al. Cigarette smoke extract induces epithelial-mesenchymal transition of human bladder cancer T24 cells through activation of ERK1/2 pathway. Biomed Pharmacother. 2017;86:457-465 pubmed publisher
    ..Meanwhile, exposure of T24 cells to CSE resulted in activation of ERK1/2 pathway as well as activator protein 1 (AP-1) proteins...
  72. Feng Z, Ma J, Hua X. Epigenetic regulation by the menin pathway. Endocr Relat Cancer. 2017;24:T147-T159 pubmed publisher
    ..modifiers and transcription factors such as MLL, PRMT5, SUV39H1 and other transcription factors including c-Myb and JunD. Moreover, the role of menin in regulating cell signaling pathways such as TGF-beta, Wnt and Hedgehog, as well as ..
  73. Pandey M, Gupta S, Nabavizadeh A, Aggarwal B. Regulation of cell signaling pathways by dietary agents for cancer prevention and treatment. Semin Cancer Biol. 2017;46:158-181 pubmed publisher
    ..Thus, the famous quote "Let food be thy medicine and medicine be thy food" made by Hippocrates 25 centuries ago still holds good. ..
  74. Baxter D, Ullman C, Frigotto L, Mason J. Exploiting Overlapping Advantages of In Vitro and In Cellulo Selection Systems to Isolate a Novel High-Affinity cJun Antagonist. ACS Chem Biol. 2017;12:2579-2588 pubmed publisher
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    ..Overall, the data indicates that OP-D may abrogate diverse signaling cascades linked to tumorigenesis, and can be used in combination with chemotherapeutic agents for cancer therapy. ..
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    ..This study was conducted to investigate whether LHRH induces activation of JunD and affects cell cycle regulation and DNA synthesis...
  77. Wu L, Li X, Wu H, Long W, Jiang X, Shen T, et al. 5-Methoxyl Aesculetin Abrogates Lipopolysaccharide-Induced Inflammation by Suppressing MAPK and AP-1 Pathways in RAW 264.7 Cells. Int J Mol Sci. 2016;17:315 pubmed publisher
    ..Our observations support the need for further research into MOA as a promising therapeutic agent in inflammatory diseases. ..
  78. Sakamuri S, Valente A, Siddesha J, Delafontaine P, Siebenlist U, Gardner J, et al. TRAF3IP2 mediates aldosterone/salt-induced cardiac hypertrophy and fibrosis. Mol Cell Endocrinol. 2016;429:84-92 pubmed publisher
    ..These results indicate that TRAF3IP2 is a critical signaling intermediate in aldosterone/salt-induced myocardial hypertrophy and fibrosis, and thus a potential therapeutic target in hypertensive heart disease...
  79. Yang H, Zhang Z, Xue L. Structural Characterization and Functional Analysis of the Follistatin Promoter of Larimichthys crocea. DNA Cell Biol. 2016;35:471-9 pubmed publisher
    ..Sequence analysis revealed several putative binding sites for transcription factors including activator protein 1 (AP1), myogenic differentiation factor (MyoD), stimulating protein 1 (SP1), and sex determining gene on the ..
  80. Hwang J, Yu H, Noh E, Kim J, Hong O, Youn H, et al. DHA blocks TPA-induced cell invasion by inhibiting MMP-9 expression via suppression of the PPAR-?/NF-?B pathway in MCF-7 cells. Oncol Lett. 2017;13:243-249 pubmed publisher
    ..This suggests that DHA could be a potential therapeutic agent for the prevention of breast cancer metastasis. ..
  81. Bhargavan B, Kanmogne G. Differential Mechanisms of Inflammation and Endothelial Dysfunction by HIV-1 Subtype-B and Recombinant CRF02_AG Tat Proteins on Human Brain Microvascular Endothelial Cells: Implications for Viral Neuropathogenesis. Mol Neurobiol. 2018;55:1352-1363 pubmed publisher
    ..B, compared to Tat.AG. This suggests these two HIV-1 subtypes differentially affect the BBB and central nervous system; our data provides novel insights into the molecular basis of these differential Tat-mediated effects. ..
  82. Kang S, Jeon C, Im K, Song M, Min H. Regulation of the viral life cycle by murine gammaherpesvirus 68 microRNAs. Arch Virol. 2017;162:657-667 pubmed publisher
    ..we observed that mghv-miR-M1-1 down-regulated c-Jun indirectly and decreased cytokine production, suggesting that mghv-miR-M1-1 may inhibit MHV-68 lytic replication by inhibiting the activator protein 1 (AP-1) signaling pathway.
  83. Hong S, Wang D, Horton J, Zhang X, Speck S, Blumenthal R, et al. Methyl-dependent and spatial-specific DNA recognition by the orthologous transcription factors human AP-1 and Epstein-Barr virus Zta. Nucleic Acids Res. 2017;45:2503-2515 pubmed publisher
    b>Activator protein 1 (AP-1) is a transcription factor that recognizes two versions of a 7-base pair response element, either 5?- GAG CA-3? or 5?- GAG CA-3? (where M = 5-methylcytosine)...
  84. Vanden Bush T, Bishop G. CDK-mediated regulation of cell functions via c-Jun phosphorylation and AP-1 activation. PLoS ONE. 2011;6:e19468 pubmed publisher
    ..These findings point to additional roles of CDKs in cell signaling and reveal potential implications for therapeutic manipulations of this kinase pathway. ..
  85. Kutky M, Hudak K. Expression of an RNA glycosidase inhibits HIV-1 transactivation of transcription. Biochem J. 2017;474:3471-3483 pubmed publisher
    ..The effects of PAP expression on host factors AP-1 (activator protein 1), NF-κB (nuclear factor kappa-light-chain-enhancer of activated B-cells) and specificity protein 1, which ..
  86. Tewari D, Nabavi S, Nabavi S, Sureda A, Farooqi A, Atanasov A, et al. Targeting activator protein 1 signaling pathway by bioactive natural agents: Possible therapeutic strategy for cancer prevention and intervention. Pharmacol Res. 2018;128:366-375 pubmed publisher
    b>Activator protein 1 (AP-1) is a key transcription factor in the control of several cellular processes responsible for cell survival proliferation and differentiation...
  87. Kuhlmann A, Villaudy J, Gazzolo L, Castellazzi M, Mesnard J, Duc Dodon M. HTLV-1 HBZ cooperates with JunD to enhance transcription of the human telomerase reverse transcriptase gene (hTERT). Retrovirology. 2007;4:92 pubmed
    ..minus strand of HTLV-1 genome and expressed in ATL cells has been shown to increase the transcriptional activity of JunD, an AP-1 protein...
  88. Chae U, Park S, Kim B, Wei S, Min J, Lee J, et al. Critical role of XBP1 in cancer signalling is regulated by PIN1. Biochem J. 2016;473:2603-10 pubmed publisher
    ..Interestingly, XBP1s activates multiple oncogenic pathways including NF-?B (nuclear factor ?B), AP1 (activator protein 1) and Myc, and down-regulates PIN1 transcription via a negative-feedback mechanism through p53 induction...
  89. Oyama N, Fuchigami Y, Fumoto S, Sato M, Hagimori M, Shimizu K, et al. Characterization of transgene expression and pDNA distribution of the suctioned kidney in mice. Drug Deliv. 2017;24:906-917 pubmed publisher
    ..Next, we confirmed the periods of pDNA uptake and activation of transcription factors nuclear factor-?B and activator protein 1 by luciferase assays...
  90. Song H, Lee G, Park S, Noh E, Kim J, Ryu D, et al. Crotonis Fructus Extract Inhibits 12-O-Tetradecanoylphorbol-13-Acetate-Induced Expression of Matrix Metalloproteinase-9 via the Activator Protein-1 Pathway in MCF-7 Cells. J Breast Cancer. 2017;20:234-239 pubmed publisher
    ..In this study, the effect of the ethanol extract of CF (CFE) on MMP-9 activity and the invasion of 12-O-tetradecanoylphorbol-13-acetate (TPA)-treated MCF-7 cells was examined...
  91. Labudova O, Krapfenbauer K, Moenkemann H, Rink H, Kitzmüller E, Cairns N, et al. Decreased transcription factor junD in brains of patients with Down syndrome. Neurosci Lett. 1998;252:159-62 pubmed
    b>JunD is a member of the Jun family of transcription factors (TF), recently shown to negatively regulate cell growth and antagonizes transformation by the protooncogene ras: c-jun decreases while junD is accumulating when fibroblasts ..
  92. Thway T, Wolfe M. An activator protein-1 complex mediates epidermal growth factor regulation of equine glycoprotein alpha subunit expression in trophoblast cells. Biol Reprod. 2002;67:972-80 pubmed
    ..The sequence within this region contains an activator protein 1 (AP-1)-like response element (TGAATCA) and is similar to a consensus AP-1 (TGAC/GTCA) response element...