Gene Symbol: JUNB
Description: JunB proto-oncogene, AP-1 transcription factor subunit
Alias: AP-1, transcription factor jun-B, activator protein 1, jun B proto-oncogene
Species: human
Products:     JUNB

Top Publications

  1. Aronheim A, Zandi E, Hennemann H, Elledge S, Karin M. Isolation of an AP-1 repressor by a novel method for detecting protein-protein interactions. Mol Cell Biol. 1997;17:3094-102 pubmed
    ..Using the Sos recruitment system, we identified new c-Jun-interacting proteins. One of these, JDP2, heterodimerizes with c-Jun in nonstimulated cells and represses AP-1-mediated activation. ..
  2. Vasanwala F, Kusam S, Toney L, Dent A. Repression of AP-1 function: a mechanism for the regulation of Blimp-1 expression and B lymphocyte differentiation by the B cell lymphoma-6 protooncogene. J Immunol. 2002;169:1922-9 pubmed
    ..We found that the zinc-finger region of BCL-6 interacts with c-Jun, JunB, and JunD proteins but does not bind c-Fos or Fra-2 proteins...
  3. Marini E, Tiberio L, Caracciolo S, Tosti G, Guzman C, Schiaffonati L, et al. HIV-1 matrix protein p17 binds to monocytes and selectively stimulates MCP-1 secretion: role of transcriptional factor AP-1. Cell Microbiol. 2008;10:655-66 pubmed
    ..Overall our results suggest that p17 may play a critical role in the monocyte-mediated inflammatory processes, which are suspected to be major precipitating events in AIDS-defining diseases. ..
  4. Ansari R, Husain K, Rizvi S. Role of Transcription Factors in Steatohepatitis and Hypertension after Ethanol: The Epicenter of Metabolism. Biomolecules. 2016;6: pubmed publisher
    ..In addition to these transcription factors, activator protein-1 may also be activated in hepatocytes due to its association with resolution of increased ROS. These transcription factors are central to alcohol-mediated hepatotoxicity. ..
  5. Furlan V, Konc J, Bren U. Inverse Molecular Docking as a Novel Approach to Study Anticarcinogenic and Anti-Neuroinflammatory Effects of Curcumin. Molecules. 2018;23: pubmed publisher
    ..are presumably mediated by the regulation of signaling cascades, including nuclear factor κB (NF-κB), activator protein 1 (AP-1), and mitogen-activated protein kinases (MAPK)...
  6. Hałatek T, Stanisławska M, Swiercz R, Domeradzka Gajda K, Kuras R, Wasowicz W. Clara cells protein, prolactin and transcription factors of protein NF-ĸB and c-Jun/AP-1 levels in rats inhaled to stainless steel welding dust and its soluble form. Int J Occup Med Environ Health. 2018;31:613-632 pubmed publisher
    ..cells secretory protein relation with prolactin in exposed rats to welding dust were shown and explored whether the NF-κB and c-Jun/activator protein 1 related pathway was involved. Int J Occup Med Environ Health 2018;31(5):613-632.
  7. Hong Y, Lee H, Jung B, Jang S, Chung D, Kim H. Lipoteichoic acid isolated from Lactobacillus plantarum down-regulates UV-induced MMP-1 expression and up-regulates type I procollagen through the inhibition of reactive oxygen species generation. Mol Immunol. 2015;67:248-55 pubmed publisher
    ..Therefore, pLTA from L. plantarum has potential abilities to prevent and treat skin photo-aging. ..
  8. Yuan R, Huang L, Du L, Feng J, Li J, Luo Y, et al. Dihydrotanshinone exhibits an anti-inflammatory effect in vitro and in vivo through blocking TLR4 dimerization. Pharmacol Res. 2019;142:102-114 pubmed publisher
    ..Taken together, our results indicated that DHT exhibited significant anti-inflammatory activity both in vitro and in vivo, suggesting that DHT may be a potential therapeutic agent for inflammatory diseases. ..
  9. Zhang Y, Guo H, Cheng B, Su T, Fu X, Li T, et al. Dingchuan tang essential oil inhibits the production of inflammatory mediators via suppressing the IRAK/NF-κB, IRAK/AP-1, and TBK1/IRF3 pathways in lipopolysaccharide-stimulated RAW264.7 cells. Drug Des Devel Ther. 2018;12:2731-2748 pubmed publisher
    ..7 macrophages. This study provides a pharmacological justification for the use of dingchuan tang in managing inflammatory disorders. ..

More Information

Publications148 found, 100 shown here

  1. Lyu D, Tang N, Wang J, Zhang Y, Chang J, Liu Z, et al. TGR5 agonist INT-777 mitigates inflammatory response in human endometriotic stromal cells: A therapeutic implication for endometriosis. Int Immunopharmacol. 2019;71:93-99 pubmed publisher
    ..Therefore, INT-777 may have an implication in the clinical treatment of endometriosis. ..
  2. Engin A. The Pathogenesis of Obesity-Associated Adipose Tissue Inflammation. Adv Exp Med Biol. 2017;960:221-245 pubmed publisher
    ..UPR) due to endoplasmic reticulum (ER) stress through hyperactivation of c-Jun N-terminal Kinase (JNK) -Activator Protein 1 (AP1) and inhibitor of nuclear factor kappa-B kinase beta (IKKbeta)-nuclear factor kappa B (NF-kappaB) ..
  3. Lee J, Chang C, Sheu J, Jayakumar T. Pharmacology and Clinical Effect of Platonin, a Cyanine Photosensitizing Dye: Potential Molecular Targets. Curr Pharm Biotechnol. 2014;15:700-11 pubmed
  4. Petronilho F, Vuolo F, Galant L, Constantino L, Tomasi C, Giombelli V, et al. Gastrin-releasing peptide receptor antagonism induces protection from lethal sepsis: involvement of toll-like receptor 4 signaling. Mol Med. 2012;18:1209-19 pubmed publisher
    ..kinase (ERK)-1/2, Jun NH(2)-terminal kinase (JNK) and Akt and decreased activation of activator protein 1 (AP-1), nuclear factor (NF)-?B and interleukin (IL)-6 in macrophages stimulated by LPS...
  5. Zhao X, Xu Z, Wang Z, Wu Z, Gong Y, Zhou L, et al. RNA silencing of integrin-linked kinase increases the sensitivity of the A549 lung cancer cell line to cisplatin and promotes its apoptosis. Mol Med Rep. 2015;12:960-6 pubmed publisher
    ..ILK inhibition may suppress the proliferation of A549 and increase A549 sensitivity to cisplatin. The combined treatment of ILK gene knockdown and chemotherapy has the potential to improve anticancer efficacy. ..
  6. Purohit V, Rapaka R, Kwon O, Song B. Roles of alcohol and tobacco exposure in the development of hepatocellular carcinoma. Life Sci. 2013;92:3-9 pubmed publisher
    ..Simultaneous exposure to alcohol and tobacco is expected to promote the development of HCC in an additive and/or synergistic manner. ..
  7. Rana A, Singh D. Targeting glycogen synthase kinase-3 for oxidative stress and neuroinflammation: Opportunities, challenges and future directions for cerebral stroke management. Neuropharmacology. 2018;139:124-136 pubmed publisher
    ..also modulates the expression of anti-inflammatory protein like, cAMP response element binding protein and activator protein 1. It has been found that the inhibition of Gsk-3 shows neuroprotection via reducing the oxidative stress and ..
  8. Maines M. Potential application of biliverdin reductase and its fragments to modulate insulin/IGF-1/MAPK/PI3-K signaling pathways in therapeutic settings. Curr Drug Targets. 2010;11:1586-94 pubmed
    ..This, points to a realistic prospect of their use in clinical settings. The present review will briefly update cytoprotective activity and cytotoxicity of bile pigments and will focus on findings that link hBVR to cell signaling. ..
  9. Gawryluk J, Young L. Signal transduction pathways in the pathophysiology of bipolar disorder. Curr Top Behav Neurosci. 2011;5:139-65 pubmed publisher
    ..The influence of mood stabilizers on transcription factors may be important in connecting the regulation of gene expression to neuroplasticity and cellular resilience. ..
  10. Yang W, Kim H, Lee J, Han N, Lee M, Park S. 1,25-dihydroxyvitamin D3 causes ADAM10-dependent ectodomain shedding of tumor necrosis factor receptor 1 in vascular smooth muscle cells. Mol Pharmacol. 2015;87:533-42 pubmed publisher
    ..By shedding TNFR1 from the cell surface, 1,25D3 may regulate inflammation and atherogenesis, whereas this effect could be attenuated by calcium channel blockers. ..
  11. Watson R, Schönlau F. Nutraceutical and antioxidant effects of a delphinidin-rich maqui berry extract Delphinol®: a review. Minerva Cardioangiol. 2015;63:1-12 pubmed
    ..Future research on Delphinol® and delphinidins may be expected to identify further health benefits. ..
  12. Newby A. Metalloproteinase production from macrophages - a perfect storm leading to atherosclerotic plaque rupture and myocardial infarction. Exp Physiol. 2016;101:1327-1337 pubmed publisher
    ..A 'perfect storm' caused by a combination of these mechanisms is most likely to promote MMP-mediated macrophage invasion, tissue destruction and atherosclerotic plaque rupture. ..
  13. Kloos B, Chakraborty S, Lindner S, Noack K, Harre U, Schett G, et al. Pasteurella multocida toxin- induced osteoclastogenesis requires mTOR activation. Cell Commun Signal. 2015;13:40 pubmed publisher
    ..Ultimately this results in the activation of c-Jun, a component of the activator protein 1 (AP-1) complex, which is a major transcription factor for the induction of osteoclast-specific genes...
  14. Liu T, Li L, Zhang F, Wang Y. Transcriptional inhibition of the Catalase gene in phosphine-induced oxidative stress in Drosophila melanogaster. Pestic Biochem Physiol. 2015;124:1-7 pubmed publisher
    ..These results confirmed that PH3 induces oxidative stress and targets CAT by downregulating its encoding gene in Drosophila. Our results provide new insight into the signal transduction mechanism between PH3 and its target genes. ..
  15. Veach R, Liu Y, Zienkiewicz J, Wylezinski L, Boyd K, Wynn J, et al. Survival, bacterial clearance and thrombocytopenia are improved in polymicrobial sepsis by targeting nuclear transport shuttles. PLoS ONE. 2017;12:e0179468 pubmed publisher
    ..transcription factors nuclear factor kappa B, signal transducer and activator of transcription 1 alpha, and activator protein 1 in liver, which was also protected from sepsis-associated metabolic changes...
  16. Faid I, Al Hussaini H, Kilarkaje N. Resveratrol alleviates diabetes-induced testicular dysfunction by inhibiting oxidative stress and c-Jun N-terminal kinase signaling in rats. Toxicol Appl Pharmacol. 2015;289:482-94 pubmed publisher
    ..These results suggest that Resveratrol supplementation may be a useful strategy to treat diabetes-induced testicular dysfunction. ..
  17. Zheng L, Xing L, Zeng C, Wu T, Gui Y, Li W, et al. Inactivation of PI3Kδ induces vascular injury and promotes aneurysm development by upregulating the AP-1/MMP-12 pathway in macrophages. Arterioscler Thromb Vasc Biol. 2015;35:368-77 pubmed publisher
  18. Kim J, Yenari M, Lee J. Regulation of inflammatory transcription factors by heat shock protein 70 in primary cultured astrocytes exposed to oxygen-glucose deprivation. Neuroscience. 2015;286:272-80 pubmed publisher
    ..Taken together, these results suggest that overexpression of Hsp70 may protect against brain ischemia via an anti-inflammatory mechanism by interrupting the phosphorylation of upstream of transcription factors. ..
  19. Zeng Y, Broxmeyer H, Staser K, Chitteti B, Park S, Hahn S, et al. Pak2 regulates hematopoietic progenitor cell proliferation, survival, and differentiation. Stem Cells. 2015;33:1630-41 pubmed publisher
    ..Pak2 disruption resulted, respectively, in decreased and increased gene expression of transcription factors JunB and c-Myc, which may suggest underlying mechanisms by which Pak2 regulates granulocyte-monocyte lineage commitment...
  20. Kong X, Kuilman T, Shahrabi A, Boshuizen J, Kemper K, Song J, et al. Cancer drug addiction is relayed by an ERK2-dependent phenotype switch. Nature. 2017;550:270-274 pubmed publisher
    ..Here we describe a signalling pathway comprising ERK2 kinase and JUNB and FRA1 transcription factors, disruption of which allowed addicted tumour cells to survive on treatment ..
  21. Sharma P, Panebra A, Pera T, Tiegs B, Hershfeld A, Kenyon L, et al. Antimitogenic effect of bitter taste receptor agonists on airway smooth muscle cells. Am J Physiol Lung Cell Mol Physiol. 2016;310:L365-76 pubmed publisher
  22. Xu B, Luo Y, Liu Y, Li B, Wang Y. Platelet-derived growth factor-BB enhances MSC-mediated cardioprotection via suppression of miR-320 expression. Am J Physiol Heart Circ Physiol. 2015;308:H980-9 pubmed publisher
    ..Collectively, we conclude that PDGF enhances MSC-mediated cardioprotection via a c-Jun/miR-320 signaling mechanism and PDGF MSC preconditioning may be an effective therapeutic strategy for cardiac ischemia. ..
  23. Debnath M, Agrawal S, Agrawal A, Dubey G. Metaflammatory responses during obesity: Pathomechanism and treatment. Obes Res Clin Pract. 2016;10:103-13 pubmed publisher
    ..Anti-inflammatory treatment so as to curb the severity of inflammatory responses includes administration of synthetic drugs to target the actual inflammatory molecules and various therapeutic interventions. ..
  24. El Salhy M, Umezawa K. Treatment with novel AP-1 and NF-κB inhibitors restores the colonic endocrine cells to normal levels in rats with DSS-induced colitis. Int J Mol Med. 2016;37:556-64 pubmed publisher
    ..rats were treated with 3-[(dodecylthiocarbonyl)‑methyl]‑glutarimide (DTCM‑G), a novel activator protein 1 (AP-1) inhibitor, 20 mg/kg in CMC; and iii) DSS‑Q group, rats were treated with ..
  25. Ishikawa C, Senba M, Mori N. Mitotic kinase PBK/TOPK as a therapeutic target for adult T‑cell leukemia/lymphoma. Int J Oncol. 2018;53:801-814 pubmed publisher
    ..IKK)α, IKKβ, IκBα, phosphatase and tensin homolog (PTEN) and Akt, and to the decreased protein expression of JunB and JunD, suggesting that PBK/TOPK affects the nuclear factor-κB, Akt and activator protein‑1 signaling pathways...
  26. Yang C, Lin C, Hsieh H. High-Glucose-Derived Oxidative Stress-Dependent Heme Oxygenase-1 Expression from Astrocytes Contributes to the Neuronal Apoptosis. Mol Neurobiol. 2017;54:470-483 pubmed publisher
    ..JNK) and then activated the downstream transcriptional factors nuclear factor-kappaB (NF-κB) and c-Fos/activator protein 1 (AP-1), respectively. Subsequently, the activated NF-κB and AP-1 turned on transcription of HO-1 gene...
  27. Chen S, Chen P, Wu Y, Chen C, Chen H, Lii C, et al. Long-chain polyunsaturated fatty acids amend palmitate-induced inflammation and insulin resistance in mouse C2C12 myotubes. Food Funct. 2016;7:270-8 pubmed publisher
    ..In addition to the NF-κB pathway, other mechanisms are involved in the health benefits of DHA and EPA in PA-treated myotubes. ..
  28. Ganti K, Mukherji A, Surjit M, Li M, Chambon P. Similarities and differences in the transcriptional control of expression of the mouse TSLP gene in skin epidermis and intestinal epithelium. Proc Natl Acad Sci U S A. 2017;114:E951-E960 pubmed publisher
    ..Furthermore, we identified several functional NF-κB, activator protein 1 (AP1), STAT, and Smad DBS in the TSLP promoter region...
  29. Umehara T, Murase T, Abe Y, Yamashita H, Shibaike Y, Kagawa S, et al. Identification of potential markers of fatal hypothermia by a body temperature-dependent gene expression assay. Int J Legal Med. 2019;133:335-345 pubmed publisher
    ..The expression of four genes [connective tissue growth factor (Ctgf), JunB proto-oncogene, AP-1 transcription factor subunit (Junb), nuclear receptor subfamily 4, group A, member 1 (Nr4a1), ..
  30. Ahn C, Jung W, Park S, Kim Y, Kim W, Je J. Gallic Acid-g-Chitosan Modulates Inflammatory Responses in LPS-Stimulated RAW264.7 Cells Via NF-κB, AP-1, and MAPK Pathways. Inflammation. 2016;39:366-374 pubmed publisher
    ..These results suggest that GAC has the potential anti-inflammatory action by downregulating transcriptional factors (NF-κB and AP-1) through MAPK signaling pathways. ..
  31. Liu X, Liu R, Croker B, Lawlor K, Smyth G, Wicks I. Distinctive pro-inflammatory gene signatures induced in articular chondrocytes by oncostatin M and IL-6 are regulated by Suppressor of Cytokine Signaling-3. Osteoarthritis Cartilage. 2015;23:1743-54 pubmed publisher
    ..Multiple genes, including Bcl3, Junb, Tgm1, Angptl4 and Lrg1, were upregulated in chondrocytes stimulated with each gp130 cytokine...
  32. Lin C, Wang Y, Chen Y, Lin Y, Chen B, Chen M. Transcriptional and posttranscriptional regulation of CXCL8/IL-8 gene expression induced by connective tissue growth factor. Immunol Res. 2016;64:369-84 pubmed publisher
    ..The results suggested that CTGF stabilized luciferase mRNA and increased luciferase activity by regulating the CXCL8/IL-8 3'-UTR. Moreover, the p38 MAPK pathway may contribute to CTGF-induced CXCL8/IL-8 mRNA stabilization. ..
  33. Cho N, Cha J, Kim H, Kwak J, Kim D, Seo S, et al. Discovery of 2-aryloxy-4-amino-quinazoline derivatives as novel protease-activated receptor 2 (PAR2) antagonists. Bioorg Med Chem. 2015;23:7717-27 pubmed publisher
    ..the regulation of various intracellular signaling pathways involving nuclear factor-κB (NF-κB), activator protein 1 (AP-1) and the mitogen-activated protein kinases (MAPK)...
  34. Chaiprasongsuk A, Lohakul J, Soontrapa K, Sampattavanich S, Akarasereenont P, Panich U. Activation of Nrf2 Reduces UVA-Mediated MMP-1 Upregulation via MAPK/AP-1 Signaling Cascades: The Photoprotective Effects of Sulforaphane and Hispidulin. J Pharmacol Exp Ther. 2017;360:388-398 pubmed publisher
    ..could relieve UVA-mediated MMP-1 upregulation via activation of mitogen-activated protein kinase (MAPK)/activator protein 1 (AP-1) signaling using human keratinocyte cell line (HaCaT)...
  35. Woo C, Lund P, Huang A, Davis M, Bertozzi C, Pitteri S. Mapping and Quantification of Over 2000 O-linked Glycopeptides in Activated Human T Cells with Isotope-Targeted Glycoproteomics (Isotag). Mol Cell Proteomics. 2018;17:764-775 pubmed publisher
    ..Notably, we observed that the transcription factors c-JUN and JUNB show higher levels of O-GlcNAc glycosylation and higher levels of expression in activated T cells...
  36. Connelly J, Mishra A, Gautrot J, Watt F. Shape-induced terminal differentiation of human epidermal stem cells requires p38 and is regulated by histone acetylation. PLoS ONE. 2011;6:e27259 pubmed publisher
    ..In addition, inhibiting p38 reduced histone H3 acetylation at the promoters of SRF target genes, FOS and JUNB. Although histone acetylation correlated with SRF transcriptional activity and target gene expression, treatment ..
  37. Murray M. CYP2J2 - regulation, function and polymorphism. Drug Metab Rev. 2016;48:351-68 pubmed publisher
    ..Additionally, the development of agents that promote fatty acid epoxide production, or stable analogs that retain the activities of the epoxides, offer promising new avenues for utilizing the beneficial actions of these molecules. ..
  38. Bae J, Han M, Shin H, Kim M, Shin C, Lee D, et al. Perilla frutescens leaves extract ameliorates ultraviolet radiation-induced extracellular matrix damage in human dermal fibroblasts and hairless mice skin. J Ethnopharmacol. 2017;195:334-342 pubmed publisher
    ..Our results demonstrate that PLE has the protective effect against UV-induced dermal matrix damage. Therefore, we suggest that PLE can be a potential agent for prevention of skin aging. ..
  39. Hao Y, Zhu L, Yan L, Liu J, Liu D, Gao N, et al. c-Fos mediates ?1, 2-fucosyltransferase 1 and Lewis y expression in response to TGF-?1 in ovarian cancer. Oncol Rep. 2017;38:3355-3366 pubmed publisher
    ..Silencing of c-Fos prevented TGF-?1-induced Lewis y expression. Collectively, the results of these studies demonstrated that TGF-?1 regulated FUT1 and Lewis y expression by activating the MAPK/c-Fos pathway...
  40. Schutte J, Viallet J, Nau M, Segal S, Fedorko J, Minna J. jun-B inhibits and c-fos stimulates the transforming and trans-activating activities of c-jun. Cell. 1989;59:987-97 pubmed
    ..These findings demonstrate that, whereas jun-B and c-jun each participate in AP-1 trans-activation and malignant transformation, interactions between them involve negative regulation. ..
  41. Zhang S, Hu Y, Huang Y, Xu H, Wu G, Dai H. Heat shock protein 27 promotes cell proliferation through activator protein-1 in lung cancer. Oncol Lett. 2015;9:2572-2576 pubmed
    ..Therefore, HSP27 may be a suitable therapeutic target for the treatment of lung cancer. ..
  42. von Moltke J, O Leary C, Barrett N, Kanaoka Y, Austen K, Locksley R. Leukotrienes provide an NFAT-dependent signal that synergizes with IL-33 to activate ILC2s. J Exp Med. 2017;214:27-37 pubmed publisher
    ..the transcription factors nuclear factor of activated T cells (NFAT), nuclear factor ?B (NF-?B), and activator protein 1 (AP-1) to induce type 2 cytokines...
  43. Cheng P, Hu C, Wang C, Lee Y, Chung W, Tseng T. Involvement of the antioxidative property of morusin in blocking phorbol ester-induced malignant transformation of JB6 P+ mouse epidermal cells. Chem Biol Interact. 2017;264:34-42 pubmed publisher
    ..In conclusion, our results evidence that morusin possesses anti-cancer promotion potential because of its antioxidant property, which mediates multiple transformation-associated gene expression. ..
  44. Wang S, He Z, Li D, Zhang B, Li M, Li W, et al. Aberrant methylation of RUNX3 is present in Aflatoxin B1-induced transformation of the L02R cell line. Toxicology. 2017;385:1-9 pubmed publisher
    ..As a result, the expression of the following seven genes including JUNB, RUNX3, NAV1, CXCR4, RARRES1, INTS1, and POLL was down-regulated in transformed L02RT-AFB1 cells...
  45. Salemi D, Cammarata G, Agueli C, Augugliaro L, Corrado C, Bica M, et al. miR-155 regulative network in FLT3 mutated acute myeloid leukemia. Leuk Res. 2015;39:883-96 pubmed publisher
    ..by the presence of six transcription factors as central hubs: four miR-155 regulators (JUN, RUNX1, FOSb, JUNB) and two targets of miR-155 (SPI1, CEBPB) all known to be "master" genes of myelopoiesis...
  46. Wang T, Han S, Wu Z, Han Z, Yan W, Liu T, et al. XCR1 promotes cell growth and migration and is correlated with bone metastasis in non-small cell lung cancer. Biochem Biophys Res Commun. 2015;464:635-41 pubmed publisher
    ..pathway of XCR1, while XCL1/XCR1 increased the mRNA level of the downstream of JAK2/STAT3 including PIM1, JunB, TTP, MMP2 and MMP9...
  47. Galán Cobo A, Ramirez Lorca R, Serna A, Echevarria M. Overexpression of AQP3 Modifies the Cell Cycle and the Proliferation Rate of Mammalian Cells in Culture. PLoS ONE. 2015;10:e0137692 pubmed publisher
    ..and the comparative analysis between both type of cells showed significant changes in the expression of Zeb2, Jun, JunB, NF-kβ, Cxcl9, Cxcl10, TNF, and TNF receptors...
  48. Kiesow K, Bennewitz K, Miranda L, Stoll S, Hartenstein B, Angel P, et al. Junb controls lymphatic vascular development in zebrafish via miR-182. Sci Rep. 2015;5:15007 pubmed publisher
    b>JUNB, a subunit of the AP-1 transcription factor complex, mediates gene regulation in response to a plethora of extracellular stimuli...
  49. Wang T, Yan J, Xu W, Ai Q, Mai K. Characterization of Cyclooxygenase-2 and its induction pathways in response to high lipid diet-induced inflammation in Larmichthys crocea. Sci Rep. 2016;6:19921 pubmed publisher
    ..The present study provides important insight into the signal transduction pathways involved in HLD-induced inflammation, which is detrimental to the health and production of fish as well as to the health of fish consumers. ..
  50. Nuzzo A, Giuffrida D, Masturzo B, Mele P, Piccoli E, Eva C, et al. Altered expression of G1/S phase cell cycle regulators in placental mesenchymal stromal cells derived from preeclamptic pregnancies with fetal-placental compromise. Cell Cycle. 2017;16:200-212 pubmed publisher
    ..Finally, we investigated normal and PE-PDMSCs paracrine effects on JunB, Cyclin D1, p16INK4A, p18INK4C, CDK4 and CDK6 expressions in physiological term villous ..
  51. Gupta S, Barrett T, Whitmarsh A, Cavanagh J, Sluss H, Derijard B, et al. Selective interaction of JNK protein kinase isoforms with transcription factors. EMBO J. 1996;15:2760-70 pubmed
    ..Individual members of the JNK group may therefore selectively target specific transcription factors in vivo. ..
  52. Hu W, Wang X, Wu L, Shen T, Ji L, Zhao X, et al. Apigenin-7-O-β-D-glucuronide inhibits LPS-induced inflammation through the inactivation of AP-1 and MAPK signaling pathways in RAW 264.7 macrophages and protects mice against endotoxin shock. Food Funct. 2016;7:1002-13 pubmed publisher
    ..Taken together, these results suggest that AG may be used as a source of anti-inflammatory agents as well as a dietary complement for health promotion. ..
  53. Takeda S, Himeno T, Kakizoe K, Okazaki H, Okada T, Watanabe K, et al. Cannabidiolic acid-mediated selective down-regulation of c-fos in highly aggressive breast cancer MDA-MB-231 cells: possible involvement of its down-regulation in the abrogation of aggressiveness. J Nat Med. 2017;71:286-291 pubmed publisher
  54. Wan S, Meyer A, Weiler S, Rupp C, Tóth M, Sticht C, et al. Cytoplasmic localization of the cell polarity factor Scribble supports liver tumor formation and tumor cell invasiveness. Hepatology. 2017;: pubmed publisher
    ..ScribP305L -dependent invasion was mediated by the AP-1 constituents ATF2 and JunB via induction of paracrine-acting secreted protein acidic and cysteine rich (SPARC)...
  55. Bai F, Liu K, Li H, Wang J, Zhu J, Hao P, et al. Veratramine modulates AP-1-dependent gene transcription by directly binding to programmable DNA. Nucleic Acids Res. 2017;: pubmed publisher
    ..The identification of veratramine and new findings in its specific regulation of AP-1 down stream genes pave ways to discovering and designing regulators to regulate transcription factor...
  56. Kanno T, Kamba T, Yamasaki T, Shibasaki N, Saito R, Terada N, et al. JunB promotes cell invasion and angiogenesis in VHL-defective renal cell carcinoma. Oncogene. 2012;31:3098-110 pubmed publisher
    ..HIF?), pVHL also controls the development of pheochromocytoma through HIF-independent pathways by regulating JunB. However, it is largely unknown how these pathways contribute to the development and progression of ccRCC...
  57. Wu S, Nin D, Lee A, Simanski S, Kodadek T, Chiang C. BRD4 Phosphorylation Regulates HPV E2-Mediated Viral Transcription, Origin Replication, and Cellular MMP-9 Expression. Cell Rep. 2016;16:1733-1748 pubmed publisher
    ..This is triggered by replacement of AP-1 family members JunB and JunD by c-Jun and by re-localization of NF-?B from the cytoplasm to the nucleus...
  58. Meng D, Zhu W, Ganguli K, Shi H, Walker W. Anti-inflammatory effects of Bifidobacterium longum subsp infantis secretions on fetal human enterocytes are mediated by TLR-4 receptors. Am J Physiol Gastrointest Liver Physiol. 2016;311:G744-G753 pubmed publisher
    ..Based on these observations, the combined use of probiotics and anti-TLR-4 therapy to prevent NEC may not be a good strategy. ..
  59. Baig M, Liu D, Muthu K, Roy A, Saqib U, Naim A, et al. Heterotrimeric complex of p38 MAPK, PKCδ, and TIRAP is required for AP1 mediated inflammatory response. Int Immunopharmacol. 2017;48:211-218 pubmed publisher
    ..Structure-based design of small molecules or peptides targetting PKCδ-TIRAP or TIRAP-p38 interfaces would be beneficial for therapy in AP1 mediated inflammatory diseases. ..
  60. Yamazaki S, Tanaka Y, Araki H, Kohda A, Sanematsu F, Arasaki T, et al. The AP-1 transcription factor JunB is required for Th17 cell differentiation. Sci Rep. 2017;7:17402 pubmed publisher
    ..Here we show that the AP-1 transcription factor JunB is required for Th17 cell development...
  61. Dorsey M, Tae H, Sollenberger K, Mascarenhas N, Johansen L, Taparowsky E. B-ATF: a novel human bZIP protein that associates with members of the AP-1 transcription factor family. Oncogene. 1995;11:2255-65 pubmed
    ..coli. However, a yeast two hybrid library screen has identified the human oncoprotein JunB as a specific binding partner for B-ATF...
  62. Henderson A, Holloway A, Reeves R, Tremethick D. Recruitment of SWI/SNF to the human immunodeficiency virus type 1 promoter. Mol Cell Biol. 2004;24:389-97 pubmed
    ..We report here that ATF-3, JunB, and BRG-1 (the ATPase subunit of the 2-MDa human chromatin remodeling machine SWI/SNF) are recruited to the 3' ..
  63. Tam W, Lu H, Buikhuisen J, Soh B, Lim E, Reinhardt F, et al. Protein kinase C ? is a central signaling node and therapeutic target for breast cancer stem cells. Cancer Cell. 2013;24:347-64 pubmed publisher
    ..Hence, identifying molecular features that shift between cell states can be exploited to target signaling components critical to CSCs. ..
  64. Rauch A, Rosskothen Kuhl N, Illing R. Counter-regulation of the AP-1 monomers pATF2 and Fos: Molecular readjustment of brainstem neurons in hearing and deaf adult rats after electrical intracochlear stimulation. Neuroscience. 2016;313:184-98 pubmed publisher
    ..This change in AP-1 constellation is expected to invoke different transcriptional cascades leading to distinct modes of tissue reorganization and plasticity responses in the mature central auditory system under stimulation. ..
  65. Lim S, Peshenko I, Olshevskaya E, Dizhoor A, Ames J. Structure of Guanylyl Cyclase Activator Protein 1 (GCAP1) Mutant V77E in a Ca2+-free/Mg2+-bound Activator State. J Biol Chem. 2016;291:4429-41 pubmed publisher
    ..We conclude that Ca(2+)-dependent conformational changes in the Ca(2+) switch helix are important for activating RetGC1 and provide further support for a Ca(2+)-myristoyl tug mechanism. ..
  66. Liu X, Hu B, Wang F, Song Y, Fan Z, Wei H, et al. Molecular cloning of the rabbit interleukin 6 promoter: Functional characterization of rabbit hemorrhagic disease virus response elements in RK-13 cells. Dev Comp Immunol. 2016;65:280-288 pubmed publisher
    ..A series of 5' deletion constructs demonstrated that AP-1 (activator protein 1), NF-IL6 (nuclear factor interleukin-6), and NF-?B (nuclear factor kappa B) elements were critical for RHDV-..
  67. Pan L, Xu P, Luo X, Wang L, Liu S, Zhu Y, et al. Shizukaol B, an active sesquiterpene from Chloranthus henryi, attenuates LPS-induced inflammatory responses in BV2 microglial cells. Biomed Pharmacother. 2017;88:878-884 pubmed publisher
    ..Taken together, our findings suggest that shizukaol B exerts anti-inflammatory effects in LPS-activated microglia partly by modulating JNK-AP-1 signaling pathway. ..
  68. Liu Q, Zhu Y, Yong W, Sze N, Tan N, Ding J. Cutting Edge: Synchronization of IRF1, JunB, and C/EBPβ Activities during TLR3-TLR7 Cross-Talk Orchestrates Timely Cytokine Synergy in the Proinflammatory Response. J Immunol. 2015;195:801-5 pubmed publisher
    ..TLR3-TIR domain-containing adaptor inducing IFN-β [TRIF] responsive), C/EBPβ (TLR7-MyD88 responsive), and JunB (all responsive)...
  69. Tang C, Chen X, Chi J, Yang D, Liu S, Liu M, et al. Pathogenic Cx31 is un/misfolded to cause skin abnormality via a Fos/JunB-mediated mechanism. Hum Mol Genet. 2015;24:6054-65 pubmed publisher
    ..gap junction formation and significant upregulation of chaperones Bip and Hsp70 as well as AP-1 proteins c-Fos and JunB, in addition to molecular signatures of skin diseases...
  70. Makino H, Seki S, Yahara Y, Shiozawa S, Aikawa Y, Motomura H, et al. A selective inhibition of c-Fos/activator protein-1 as a potential therapeutic target for intervertebral disc degeneration and associated pain. Sci Rep. 2017;7:16983 pubmed publisher
    ..These findings suggest that the inhibition of c-Fos/AP-1 prevents disc degeneration and its associated pain and that T-5224 may serve as a drug for the prevention of IVD degeneration. ..
  71. Wong K, Cai Y, Ying F, Chen X, Vanhoutte P, Tang E. Deletion of Rap1 disrupts redox balance and impairs endothelium-dependent relaxations. J Mol Cell Cardiol. 2018;115:1-9 pubmed publisher
    Repressor activator protein 1 (Rap1) is conventionally known as a static structural component of the telomere, but recent evidence indicates that it exerts functions within and outside the nucleus taking part in metabolic regulation and ..
  72. Thiel G, Rössler O. Resveratrol stimulates c-Fos gene transcription via activation of ERK1/2 involving multiple genetic elements. Gene. 2018;658:70-75 pubmed publisher
    ..Pharmacological and genetic experiments revealed that the protein kinase ERK1/2 is the signal transducer that connects resveratrol treatment with the c-Fos gene. ..
  73. Garces de Los Fayos Alonso I, Liang H, Turner S, Lagger S, Merkel O, Kenner L. The Role of Activator Protein-1 (AP-1) Family Members in CD30-Positive Lymphomas. Cancers (Basel). 2018;10: pubmed publisher
    ..In this review, we focus on the impact of deregulated expression of AP-1 TFs in CD30-positive lymphomas including Classical Hodgkin Lymphoma and Anaplastic Large Cell Lymphoma. ..
  74. Chen H, Ma J, Sunkel B, Luo A, Ding F, Li Y, et al. S100A14: novel modulator of terminal differentiation in esophageal cancer. Mol Cancer Res. 2013;11:1542-53 pubmed publisher
    ..Finally, it was determined that S100A14 is transcriptionally regulated by JunB and that S100A14 and JunB status significantly correlated in ESCC tissue...
  75. Hwang Y, Lindholm P. Constitutive and Inducible Expression of Invasion-related Factors in PC-3 Prostate Cancer Cells. J Cancer Prev. 2015;20:121-8 pubmed publisher
    ..Highly invasive PC-3 cells showed higher nuclear factor kappa B (NF-κB), activator protein 1 (AP-1) and RhoA activities than of low invasive PC-3 cells...
  76. Patil R, Babu R, Naveen Kumar M, Kiran Kumar K, Hegde S, Nagesh R, et al. Anti-Inflammatory Effect of Apigenin on LPS-Induced Pro-Inflammatory Mediators and AP-1 Factors in Human Lung Epithelial Cells. Inflammation. 2016;39:138-147 pubmed publisher
    ..of pro-inflammatory cytokines (IL-1β, IL-2, IL-6, IL-8, and TNF-α), and AP-1 proteins (c-Jun, c-Fos, and JunB) including nitric oxide production...
  77. Wassermann Dozorets R, Rubinstein M. C/EBPβ LIP augments cell death by inducing osteoglycin. Cell Death Dis. 2017;8:e2733 pubmed publisher
    ..increased Ogn expression and cell death under stress by modulating the mitogen-activated protein kinase/activator protein 1 pathway (MAPK/AP-1)...
  78. Jiang Z, Song F, Li Y, Xue D, Deng G, Li M, et al. Capsular Polysaccharide is a Main Component of Mycoplasma ovipneumoniae in the Pathogen-Induced Toll-Like Receptor-Mediated Inflammatory Responses in Sheep Airway Epithelial Cells. Mediators Inflamm. 2017;2017:9891673 pubmed publisher
    ..These results suggested that CPS is a key virulent component of M. ovipneumoniae, which may play a crucial role in the inflammatory response induced by M. ovipneumoniae infections. ..
  79. Yin Z, Machius M, Nestler E, Rudenko G. Activator Protein-1: redox switch controlling structure and DNA-binding. Nucleic Acids Res. 2017;45:11425-11436 pubmed publisher
    ..The molecular and structural studies presented here thus reveal the mechanism underlying redox-regulation of AP-1 Fos/Jun transcription factors and provide structural insight for therapeutic interventions targeting AP-1 proteins. ..
  80. Lee Y, Yap H, Shaari K, Tham C, Sulaiman M, Israf D. Blockade of Eosinophil-Induced Bronchial Epithelial-Mesenchymal Transition with a Geranyl Acetophenone in a Coculture Model. Front Pharmacol. 2017;8:837 pubmed publisher
    ..These findings corroborated previous findings on the ability of tHGA to inhibit experimental murine airway remodeling...
  81. Lian S, Shao Y, Liu H, He J, Lu W, Zhang Y, et al. PDK1 induces JunB, EMT, cell migration and invasion in human gallbladder cancer. Oncotarget. 2015;6:29076-86 pubmed publisher
    ..we showed that PDK1 stimulated cell proliferation, invasion and metastasis in gallbladder cancer (GBC), by inducing JunB and epithelial-mesenchymal transition...
  82. Oyama N, Fuchigami Y, Fumoto S, Sato M, Hagimori M, Shimizu K, et al. Characterization of transgene expression and pDNA distribution of the suctioned kidney in mice. Drug Deliv. 2017;24:906-917 pubmed publisher
    ..Next, we confirmed the periods of pDNA uptake and activation of transcription factors nuclear factor-?B and activator protein 1 by luciferase assays...
  83. Song H, Lee G, Park S, Noh E, Kim J, Ryu D, et al. Crotonis Fructus Extract Inhibits 12-O-Tetradecanoylphorbol-13-Acetate-Induced Expression of Matrix Metalloproteinase-9 via the Activator Protein-1 Pathway in MCF-7 Cells. J Breast Cancer. 2017;20:234-239 pubmed publisher
    ..In this study, the effect of the ethanol extract of CF (CFE) on MMP-9 activity and the invasion of 12-O-tetradecanoylphorbol-13-acetate (TPA)-treated MCF-7 cells was examined...
  84. Mao X, Orchard G, Lillington D, Russell Jones R, Young B, Whittaker S. Amplification and overexpression of JUNB is associated with primary cutaneous T-cell lymphomas. Blood. 2003;101:1513-9 pubmed
    ..Using genomic microarray, we detected oncogene copy number gains of RAF1 (3p25), CTSB (8p22), PAK1 (11q13), and JUNB (19p13) in 5 of 7 cases of mycosis fungoides (MF)/Sezary syndrome (SS) (71%), gains of FGFR1 (8p11), PTPN (20q13), ..
  85. Kutky M, Hudak K. Expression of an RNA glycosidase inhibits HIV-1 transactivation of transcription. Biochem J. 2017;474:3471-3483 pubmed publisher
    ..The effects of PAP expression on host factors AP-1 (activator protein 1), NF-κB (nuclear factor kappa-light-chain-enhancer of activated B-cells) and specificity protein 1, which ..
  86. Tewari D, Nabavi S, Nabavi S, Sureda A, Farooqi A, Atanasov A, et al. Targeting activator protein 1 signaling pathway by bioactive natural agents: Possible therapeutic strategy for cancer prevention and intervention. Pharmacol Res. 2018;128:366-375 pubmed publisher
    b>Activator protein 1 (AP-1) is a key transcription factor in the control of several cellular processes responsible for cell survival proliferation and differentiation...
  87. Strathdee G, Ferguson S, Sim A, Brown R. DNA methylation does not regulate JUNB expression in CML: comment on "Downregulation of JUNB mRNA expression in advanced phase chronic myelogenous leukemia" by Hoshino et al. [Leuk. Res. 33 (2009) 1361-1366]. Leuk Res. 2010;34:685-6 pubmed publisher
  88. Miao Z, Ding J. Transcription factor c-Jun activation represses mdr-1 gene expression. Cancer Res. 2003;63:4527-32 pubmed
    ..mobility shift assay analysis showed that salvicine enhanced DNA binding activity of transcription factor activator protein 1. Additionally, c-jun antisense oligodeoxynucleotides also inhibited salvicine-induced apoptosis and ..
  89. Chae U, Park S, Kim B, Wei S, Min J, Lee J, et al. Critical role of XBP1 in cancer signalling is regulated by PIN1. Biochem J. 2016;473:2603-10 pubmed publisher
    ..Interestingly, XBP1s activates multiple oncogenic pathways including NF-?B (nuclear factor ?B), AP1 (activator protein 1) and Myc, and down-regulates PIN1 transcription via a negative-feedback mechanism through p53 induction...
  90. Ito T, Yamauchi M, Nishina M, Yamamichi N, Mizutani T, Ui M, et al. Identification of SWI.SNF complex subunit BAF60a as a determinant of the transactivation potential of Fos/Jun dimers. J Biol Chem. 2001;276:2852-7 pubmed
    ..These results indicate that a specific subset of Fos/Jun dimers recruits SWI.SNF complex via BAF60a to initiate transcription. ..
  91. Trøen G, Nygaard V, Jenssen T, Ikonomou I, Tierens A, Matutes E, et al. Constitutive expression of the AP-1 transcription factors c-jun, junD, junB, and c-fos and the marginal zone B-cell transcription factor Notch2 in splenic marginal zone lymphoma. J Mol Diagn. 2004;6:297-307 pubmed
    ..The AP-1 transcription factors c-jun, junD, junB, and c-fos as well as Notch2 were found to be specifically up-regulated...
  92. Czimmerer Z, Horvath A, Dániel B, Nagy G, Cuaranta Monroy I, Kiss M, et al. Dynamic transcriptional control of macrophage miRNA signature via inflammation responsive enhancers revealed using a combination of next generation sequencing-based approaches. Biochim Biophys Acta Gene Regul Mech. 2018;1861:14-28 pubmed publisher
    ..Based on NF?B-p65 and JunB transcription factor binding, we showed two distinct enhancer subsets associated with LPS-activated miRNAs that ..