Gene Symbol: JFC1
Description: synaptotagmin like 1
Alias: JFC1, SLP1, synaptotagmin-like protein 1, NADPH oxidase-related, C2 domain-containing protein, exophilin-7
Species: human
Products:     JFC1

Top Publications

  1. Holt O, Kanno E, Bossi G, Booth S, Daniele T, Santoro A, et al. Slp1 and Slp2-a localize to the plasma membrane of CTL and contribute to secretion from the immunological synapse. Traffic. 2008;9:446-57 pubmed publisher
    ..In this study, we screened for expression of the synaptotagmin-like proteins (Slps): Slp1/JFC1, Slp2-a/exophilin4, Slp3-a, Slp4/granuphilin, Slp5 and rabphilin in CTL...
  2. McAdara Berkowitz J, Catz S, Johnson J, Ruedi J, Thon V, Babior B. JFC1, a novel tandem C2 domain-containing protein associated with the leukocyte NADPH oxidase. J Biol Chem. 2001;276:18855-62 pubmed
    ..Using as bait the C-terminal half of p67(phox), which contains both Src homology 3 domains, we have cloned JFC1, a novel human 62-kDa protein. JFC1 possesses two C2 domains in tandem...
  3. Johnson J, Ellis B, Noack D, Seabra M, Catz S. The Rab27a-binding protein, JFC1, regulates androgen-dependent secretion of prostate-specific antigen and prostatic-specific acid phosphatase. Biochem J. 2005;391:699-710 pubmed
    ..In the present paper, we provide evidence that JFC1 [synaptotagmin-like protein (slp1)], a Rab27a- and PtdIns(3,4,5)P3-binding protein, regulates the androgen-dependent secretion of PSAP and PSA in ..
  4. Fukuda M, Mikoshiba K. Synaptotagmin-like protein 1-3: a novel family of C-terminal-type tandem C2 proteins. Biochem Biophys Res Commun. 2001;281:1226-33 pubmed
    ..We have cloned and characterized a novel family of C-type tandem C2 proteins, designated Slp1-3 (synaptotagmin-like protein 1-3)...
  5. Strom M, Hume A, Tarafder A, Barkagianni E, Seabra M. A family of Rab27-binding proteins. Melanophilin links Rab27a and myosin Va function in melanosome transport. J Biol Chem. 2002;277:25423-30 pubmed
    ..function, we searched for proteins that interact with Rab27a(GTP) using the yeast two-hybrid system and identified JFC1/Slp1, a protein of unknown function...
  6. Wang H, Ishizaki R, Xu J, Kasai K, Kobayashi E, Gomi H, et al. The Rab27a effector exophilin7 promotes fusion of secretory granules that have not been docked to the plasma membrane. Mol Biol Cell. 2013;24:319-30 pubmed publisher
    ..We found that one of the putative Rab27a effector family proteins, exophilin7/JFC1/Slp1, is expressed in β cells; however, unlike granuphilin, exophilin7 overexpressed in the β-cell line MIN6 ..
  7. Vasnier C, De Muyt A, Zhang L, Tessé S, KLECKNER N, Zickler D, et al. Absence of SUN-domain protein Slp1 blocks karyogamy and switches meiotic recombination and synapsis from homologs to sister chromatids. Proc Natl Acad Sci U S A. 2014;111:E4015-23 pubmed publisher
    ..We identify sun like protein 1 (Slp1), member of the mid-Sad1p, UNC-84-domain ubiquitous family, as essential for karyogamy in the filamentous fungus ..
  8. Marth C, Firestone S, Hanlon D, Glenton L, Browning G, Young N, et al. Innate immune genes in persistent mating-induced endometritis in horses. Reprod Fertil Dev. 2018;30:533-545 pubmed publisher
    ..The diagnostic sensitivity of assays for EBD1, LYZ and SLP1 gene expression to detect susceptibility to PMIE was estimated to be 100%, 94% and 100% respectively, with ..
  9. Suhr M, Unger N, Viacava K, Günther T, Raff J, Pollmann K. Investigation of metal sorption behavior of Slp1 from Lysinibacillus sphaericus JG-B53: a combined study using QCM-D, ICP-MS and AFM. Biometals. 2014;27:1337-49 pubmed publisher
    ..The comparison between different methods allowed a deeper understanding of the metal sorption of isolated S-layer either frees in liquid, adsorbed forming a protein layer or as the bacteria surface. ..

More Information


  1. Walrad P, Hang S, Joseph G, Salas J, Gergen J. Distinct contributions of conserved modules to Runt transcription factor activity. Mol Biol Cell. 2010;21:2315-26 pubmed publisher
    ..regions that participate in the transcriptional activation and repression of the segmentation gene sloppy-paired-1 (slp1)...
  2. Rostoker R, Ben Shmuel S, Rashed R, Shen Orr Z, LeRoith D. CD24 cell surface expression in Mvt1 mammary cancer cells serves as a biomarker for sensitivity to anti-IGF1R therapy. Breast Cancer Res. 2016;18:51 pubmed publisher
    ..We found in both cells and tumors a marked upregulation in CTFG and a significant reduction of SLP1 expression in the CD24(+)/IGF1R-KD; tumor-suppressor and tumor-promoting genes respectively...
  3. Hou R, Chen J, Yue C, Li X, Liu J, Gao Z, et al. Modification of lily polysaccharide by selenylation and the immune-enhancing activity. Carbohydr Polym. 2016;142:73-81 pubmed publisher
    ..Nine selenizing LPs, sLP1-sLP9, were obtained and their immune-enhancing activities were compared taking unmodified LP as control...
  4. Zich J, May K, Paraskevopoulos K, Sen O, Syred H, van der Sar S, et al. Mps1Mph1 Kinase Phosphorylates Mad3 to Inhibit Cdc20Slp1-APC/C and Maintain Spindle Checkpoint Arrests. PLoS Genet. 2016;12:e1005834 pubmed publisher
    ..are potent APC/C inhibitors in vitro, demonstrating that Mad3p modification can directly influence Cdc20(Slp1)-APC/C activity...
  5. Singh G, Karade S, Ranjan R, Ahamad N, Ahmed S. C-terminal region of Mad2 plays an important role during mitotic spindle checkpoint in fission yeast Schizosaccharomyces pombe. Mol Biol Rep. 2017;44:89-96 pubmed publisher
    ..deficiency 2 (Mad2) protein is an essential component of the spindle assembly checkpoint that interacts with Cdc20/Slp1 and inhibit its ability to activate anaphase promoting complex/cyclosome (APC/C)...
  6. Mejía Barajas J, Montoya Pérez R, Salgado Garciglia R, Aguilera Aguirre L, Cortés Rojo C, Mejía Zepeda R, et al. Oxidative stress and antioxidant response in a thermotolerant yeast. Braz J Microbiol. 2017;48:326-332 pubmed publisher
    ..In the present study, three yeasts (Saccharomyces cerevisiae, MC4, and Kluyveromyces marxianus, OFF1 and SLP1) isolated from hot environments were exposed to increased temperatures and were then compared with a laboratory ..
  7. Chikashige Y, Yamane M, Okamasa K, Osakada H, Tsutsumi C, Nagahama Y, et al. Fission yeast APC/C activators Slp1 and Fzr1 sequentially trigger two consecutive nuclear divisions during meiosis. FEBS Lett. 2017;591:1029-1040 pubmed publisher
    ..In this mutant, we found that the initiation codon of the slp1+ gene is converted to ATA, producing a reduced amount of Slp1...
  8. Bessho Uehara K, Wang D, Furuta T, Minami A, Nagai K, Gamuyao R, et al. Loss of function at RAE2, a previously unidentified EPFL, is required for awnlessness in cultivated Asian rice. Proc Natl Acad Sci U S A. 2016;113:8969-74 pubmed publisher
    ..OF AWN ELONGATION 2 (RAE2) and identify one of its requisite processing enzymes, SUBTILISIN-LIKE PROTEASE 1 (SLP1)...
  9. Zhou Z, Pang Z, Li G, Lin C, Wang J, Lv Q, et al. Endoplasmic reticulum membrane-bound MoSec62 is involved in the suppression of rice immunity and is essential for the pathogenicity of Magnaporthe oryzae. Mol Plant Pathol. 2016;17:1211-22 pubmed publisher
    ..exploration, we tested the pathogenicity on a highly susceptible rice variety and detected the accumulation of Slp1, a known PTI suppressor. Both results suggested that the mutant most likely failed to overcome rice PTI...
  10. Xu L, Liang K, Duan B, Yu M, Meng W, Wang Q, et al. A Novel Insecticidal Peptide SLP1 Produced by Streptomyces laindensis H008 against Lipaphis erysimi. Molecules. 2016;21: pubmed publisher
    ..Finally, a novel insecticidal peptide was purified from Streptomyces laindensis H008 against L. erysimi, and it was determined to be S-E-P-A-Q-I-V-I-V-D-G-V-D-Y-W by TOF-MS and amino acid analysis. ..
  11. Kurz A, Pruenster M, Rohwedder I, Ramadass M, Schäfer K, Harrison U, et al. MST1-dependent vesicle trafficking regulates neutrophil transmigration through the vascular basement membrane. J Clin Invest. 2016;126:4125-4139 pubmed publisher
    ..Furthermore, we found that MST1 associates with the Rab27 effector protein synaptotagmin-like protein 1 (JFC1, encoded by Sytl1 in mice), but not Munc13-4, thereby regulating the trafficking of Rab27-positive vesicles to the ..
  12. Hang S, Gergen J. Different modes of enhancer-specific regulation by Runt and Even-skipped during Drosophila segmentation. Mol Biol Cell. 2017;28:681-691 pubmed publisher
    The initial metameric expression of the Drosophila sloppy paired 1 (slp1) gene is controlled by two distinct cis-regulatory DNA elements that interact in a nonadditive manner to integrate inputs from transcription ..
  13. Suhr M, Raff J, Pollmann K. Au-Interaction of Slp1 Polymers and Monolayer from Lysinibacillus sphaericus JG-B53 - QCM-D, ICP-MS and AFM as Tools for Biomolecule-metal Studies. J Vis Exp. 2016;:e53572 pubmed publisher
    In this publication the gold sorption behavior of surface layer (S-layer) proteins (Slp1) of Lysinibacillus sphaericus JG-B53 is described...
  14. Neumüller O, Hoffmeister M, Babica J, Prelle C, Gegenbauer K, Smolenski A. Synaptotagmin-like protein 1 interacts with the GTPase-activating protein Rap1GAP2 and regulates dense granule secretion in platelets. Blood. 2009;114:1396-404 pubmed publisher
    ..of Rap1GAP2-associated proteins, we performed yeast-2-hybrid screening and found synaptotagmin-like protein 1 (Slp1) as a new binding partner...
  15. Sun T, Li Y, Li T, Ma H, Guo Y, Jiang X, et al. JIP1 and JIP3 cooperate to mediate TrkB anterograde axonal transport by activating kinesin-1. Cell Mol Life Sci. 2017;74:4027-4044 pubmed publisher
    ..axonal delivery is mediated by kinesin-1, which associates with TrkB via the adaptor protein JIP3 or the Slp1/Rab27B/CRMP-2 protein complex. However, little is known about the activation mechanisms of TrkB-loaded kinesin-1...
  16. Meyer M, Bauer R, Letang B, Brighton L, Thompson E, Simmen R, et al. Regulation and activity of secretory leukoprotease inhibitor (SLPI) is altered in smokers. Am J Physiol Lung Cell Mol Physiol. 2014;306:L269-76 pubmed publisher
    ..Together, our findings show that SLPI regulation and activity is altered in the nasal mucosa of smokers, which could have broad implications in the context of respiratory inflammation and infection. ..
  17. Hampson A, O CONNOR A, Smolenski A. Synaptotagmin-like protein 4 and Rab8 interact and increase dense granule release in platelets. J Thromb Haemost. 2013;11:161-8 pubmed publisher
    ..Slp4 and Rab8 are expressed and interact in human platelets, and might be involved in dense granule release. ..
  18. Mejía Barajas J, Martínez Mora J, Salgado Garciglia R, Noriega Cisneros R, Ortiz Avila O, Cortés Rojo C, et al. Electron transport chain in a thermotolerant yeast. J Bioenerg Biomembr. 2017;49:195-203 pubmed publisher
    ..We studied mitochondrial functions of the thermotolerant Kluyveromyces marxianus SLP1 and the mesophilic OFF1 yeasts, through the evaluation of its mitochondrial membrane potential (??m), ..
  19. Catz S, Babior B, Johnson J. JFC1 is transcriptionally activated by nuclear factor-kappaB and up-regulated by tumour necrosis factor alpha in prostate carcinoma cells. Biochem J. 2002;367:791-9 pubmed
    The human promoter region of JFC1, a phosphatidylinositol 3,4,5-trisphosphate binding ATPase, was isolated by amplification of a 549 bp region upstream of the jfc1 gene by the use of a double-PCR system...
  20. Cen K, Li B, Lu Y, Zhang S, Wang C. Divergent LysM effectors contribute to the virulence of Beauveria bassiana by evasion of insect immune defenses. PLoS Pathog. 2017;13:e1006604 pubmed publisher
    ..Interestingly, the virulence defects of ?Blys2 and ?Blys5 could be fully restored by complementation with the Slp1 effector from the rice blast fungus Magnaporthe oryzae...
  21. Zhang W, MacDonald E, Koepp D. The stomatin-like protein SLP-1 and Cdk2 interact with the F-Box protein Fbw7-?. PLoS ONE. 2012;7:e47736 pubmed publisher
    ..We demonstrate that Cdk2 also binds the N-terminal domain of Fbw7-? as well as SLP-1. Interestingly, co-expression of Cdk2 and SLP-1 does not inhibit Fbw7-? degradation, suggesting that Cdk2 and SLP-1 may have opposing functions. ..
  22. Schmid M, Fellermann K, Fritz P, Wiedow O, Stange E, Wehkamp J. Attenuated induction of epithelial and leukocyte serine antiproteases elafin and secretory leukocyte protease inhibitor in Crohn's disease. J Leukoc Biol. 2007;81:907-15 pubmed
    ..This could contribute to the transmural depth of tissue destruction in CD. Elafin and SLPI may be added to the list of defensin-like peptides with diminished induction in CD versus UC. ..
  23. Yokoyama T, Nakatake M, Kuwata T, Couzinet A, Goitsuka R, Tsutsumi S, et al. MEIS1-mediated transactivation of synaptotagmin-like 1 promotes CXCL12/CXCR4 signaling and leukemogenesis. J Clin Invest. 2016;126:1664-78 pubmed publisher
    ..as gene expression alterations in MEIS1-deficent cells and identified synaptotagmin-like 1 (Sytl1, also known as Slp1) as the MEIS1 target gene that cooperates with Hoxa9 in leukemogenesis...
  24. Liu G, Yang J, Zhao Y, Wang Z, Xing B, Wang L, et al. Expression of secretory leukocyte protease inhibitor detected by immunohistochemistry correlating with prognosis and metastasis in colorectal cancer. World J Surg Oncol. 2014;12:369 pubmed publisher
    ..613, P=0.871). Upregulated SLPI correlates with aggressive pathologic characteristics of colorectal cancer; SLPI could be used as an indicator of progression and metastasis in patients with colorectal cancer. ..
  25. Johnson J, Ramadass M, He J, Brown S, Zhang J, Abgaryan L, et al. Identification of Neutrophil Exocytosis Inhibitors (Nexinhibs), Small Molecule Inhibitors of Neutrophil Exocytosis and Inflammation: DRUGGABILITY OF THE SMALL GTPase Rab27a. J Biol Chem. 2016;291:25965-25982 pubmed
    ..approach to identify small molecule inhibitors of the interaction between the small GTPase Rab27a and its effector JFC1, two central regulators of neutrophil exocytosis...
  26. Johnson J, Monfregola J, Napolitano G, Kiosses W, Catz S. Vesicular trafficking through cortical actin during exocytosis is regulated by the Rab27a effector JFC1/Slp1 and the RhoA-GTPase-activating protein Gem-interacting protein. Mol Biol Cell. 2012;23:1902-16 pubmed publisher
    ..RhoA-GTPase-activating protein Gem-interacting protein (GMIP) as a factor that associates with the Rab27a effector JFC1 and modulates vesicular transport and exocytosis...
  27. Zhang S, Xu C, Larrimore K, Ng D. Slp1-Emp65: A Guardian Factor that Protects Folding Polypeptides from Promiscuous Degradation. Cell. 2017;171:346-357.e12 pubmed publisher
    ..In this study, we show that a conserved endoplasmic reticulum (ER) membrane protein complex, consisting of Slp1 and Emp65 proteins, performs this function in the ER lumen...