JARID2

Summary

Gene Symbol: JARID2
Description: jumonji and AT-rich interaction domain containing 2
Alias: JMJ, protein Jumonji, jumonji homolog, jumonji, AT rich interactive domain 2, jumonji-like protein, jumonji/ARID domain-containing protein 2
Species: human
Products:     JARID2

Top Publications

  1. Kim T, Chen J, Sadoshima J, Lee Y. Jumonji represses atrial natriuretic factor gene expression by inhibiting transcriptional activities of cardiac transcription factors. Mol Cell Biol. 2004;24:10151-60 pubmed
    Mice with a homozygous knockout of the jumonji (jmj) gene showed abnormal heart development and defective regulation of cardiac-specific genes, including the atrial natriuretic factor (ANF)...
  2. Puda A, Milosevic J, Berg T, Klampfl T, Harutyunyan A, Gisslinger B, et al. Frequent deletions of JARID2 in leukemic transformation of chronic myeloid malignancies. Am J Hematol. 2012;87:245-50 pubmed publisher
    ..The common deleted region on 6p mapped to a 1.1-Mb region and contained only the JARID2 gene--member of the polycomb repressive complex 2 (PRC2)...
  3. Walters Z, Villarejo Balcells B, Olmos D, Buist T, Missiaglia E, Allen R, et al. JARID2 is a direct target of the PAX3-FOXO1 fusion protein and inhibits myogenic differentiation of rhabdomyosarcoma cells. Oncogene. 2014;33:1148-57 pubmed publisher
    ..Here we show that JARID2, which encodes a protein known to recruit various complexes with histone-methylating activity to their target ..
  4. Kim T, Kraus J, Chen J, Lee Y. JUMONJI, a critical factor for cardiac development, functions as a transcriptional repressor. J Biol Chem. 2003;278:42247-55 pubmed
    JUMONJI (JMJ) is a nuclear factor that is critical for normal cardiovascular development, evidenced by the analysis of jmj homozygous mutant mice. However, the molecular function of JMJ remains to be elucidated...
  5. He A, Shen X, Ma Q, Cao J, von Gise A, Zhou P, et al. PRC2 directly methylates GATA4 and represses its transcriptional activity. Genes Dev. 2012;26:37-42 pubmed publisher
    ..Our results reveal a new mechanism of PRC2-mediated transcriptional repression in which PRC2 methylates a transcription factor to inhibit its transcriptional activity. ..
  6. Li G, Margueron R, Ku M, Chambon P, Bernstein B, Reinberg D. Jarid2 and PRC2, partners in regulating gene expression. Genes Dev. 2010;24:368-80 pubmed publisher
    ..How mammalian PRC2 accesses chromatin is unclear. We found that Jarid2 associates with PRC2 and stimulates its enzymatic activity in vitro...
  7. Pasini D, Cloos P, Walfridsson J, Olsson L, Bukowski J, Johansen J, et al. JARID2 regulates binding of the Polycomb repressive complex 2 to target genes in ES cells. Nature. 2010;464:306-10 pubmed publisher
    ..Here we show that PRC2 forms a stable complex with the Jumonji- and ARID-domain-containing protein, JARID2 (ref. 4)...
  8. Kaneko S, Bonasio R, Saldaña Meyer R, Yoshida T, Son J, Nishino K, et al. Interactions between JARID2 and noncoding RNAs regulate PRC2 recruitment to chromatin. Mol Cell. 2014;53:290-300 pubmed publisher
    b>JARID2 is an accessory component of Polycomb repressive complex-2 (PRC2) required for the differentiation of embryonic stem cells (ESCs)...
  9. da Rocha S, Boeva V, Escamilla Del Arenal M, Ancelin K, Granier C, Matias N, et al. Jarid2 Is Implicated in the Initial Xist-Induced Targeting of PRC2 to the Inactive X Chromosome. Mol Cell. 2014;53:301-16 pubmed publisher
    ..Here, we demonstrate that the PRC2 cofactor Jarid2 is an important mediator of Xist-induced PRC2 targeting...

More Information

Publications92

  1. Mysliwiec M, Carlson C, Tietjen J, Hung H, Ansari A, Lee Y. Jarid2 (Jumonji, AT rich interactive domain 2) regulates NOTCH1 expression via histone modification in the developing heart. J Biol Chem. 2012;287:1235-41 pubmed publisher
    b>Jarid2/Jumonji, the founding member of the Jmj factor family, critically regulates various developmental processes, including cardiovascular development...
  2. Bolisetty M, Dy G, Tam W, Beemon K. Reticuloendotheliosis virus strain T induces miR-155, which targets JARID2 and promotes cell survival. J Virol. 2009;83:12009-17 pubmed publisher
    ..To study the role of miR-155 in these tumors, we identified JARID2/Jumonji, a cell cycle regulator and part of a histone methyltransferase complex, as a target of miR-155...
  3. Zhang Q, McKenzie N, Warneford Thomson R, Gail E, Flanigan S, Owen B, et al. RNA exploits an exposed regulatory site to inhibit the enzymatic activity of PRC2. Nat Struct Mol Biol. 2019;: pubmed publisher
    ..RNA-mediated inhibition of holo-PRC2 is relieved by allosteric activation of PRC2 by H3K27me3 and JARID2-K116me3 peptides. Both holo-PRC2.1 and holo-PRC2...
  4. Son J, Shen S, Margueron R, Reinberg D. Nucleosome-binding activities within JARID2 and EZH1 regulate the function of PRC2 on chromatin. Genes Dev. 2013;27:2663-77 pubmed publisher
    ..Several ancillary factors, including Jarid2, modulate PRC2 function, with Jarid2 facilitating its recruitment to target genes...
  5. Cho E, Kang H, Kang D, Lee Y. Myocardial-specific ablation of Jumonji and AT-rich interaction domain-containing 2 (Jarid2) leads to dilated cardiomyopathy in mice. J Biol Chem. 2019;294:4981-4996 pubmed publisher
    ..Jumonji and AT-rich interaction domain-containing 2 (Jarid2) is necessary for embryonic heart development, but functions of Jarid2 after birth remain to be elucidated...
  6. Fellous A, Earley R, Silvestre F. The Kdm/Kmt gene families in the self-fertilizing mangrove rivulus fish, Kryptolebias marmoratus, suggest involvement of histone methylation machinery in development and reproduction. Gene. 2019;687:173-187 pubmed publisher
    ..Twenty-five Kdm orthologues (Jarid2, Jmjd1c, Jmjd4, Jmjd6, Jmjd7, Jmjd8, Kdm1a, Kdm1b, Kdm2a, Kdm2b, Kdm3b, Kdm4a, Kdm4b, Kdm4c, Kdm5a, Kdm5b, Kdm5c, ..
  7. Celik H, Koh W, Kramer A, Ostrander E, Mallaney C, Fisher D, et al. JARID2 Functions as a Tumor Suppressor in Myeloid Neoplasms by Repressing Self-Renewal in Hematopoietic Progenitor Cells. Cancer Cell. 2018;34:741-756.e8 pubmed publisher
    ..b>JARID2 is lost by chromosomal deletions in a proportion of MPN/MDS cases that progress to sAML...
  8. Al Raawi D, Jones R, Wijesinghe S, Halsall J, Petric M, Roberts S, et al. A novel form of JARID2 is required for differentiation in lineage-committed cells. EMBO J. 2019;38: pubmed publisher
    ..b>JARID2 is a co-factor of PRC2 and is important for targeting PRC2 to chromatin...
  9. Liu Y, Dong Y, Zhu X, Fan H, Xu M, Chen Q, et al. MiR-155 inhibition ameliorates 2, 4, 6-Trinitrobenzenesulfonic acid (TNBS)-induced experimental colitis in rat via influencing the differentiation of Th17 cells by Jarid2. Int Immunopharmacol. 2018;64:401-410 pubmed publisher
    ..Finally, we discovered that Jarid2 was significantly elevated (P < 0...
  10. Conway E, Jerman E, Healy E, Ito S, Holoch D, Oliviero G, et al. A Family of Vertebrate-Specific Polycombs Encoded by the LCOR/LCORL Genes Balance PRC2 Subtype Activities. Mol Cell. 2018;70:408-421.e8 pubmed publisher
    ..Whereas two distinct forms exist, PRC2.1 (containing one polycomb-like protein) and PRC2.2 (containing AEBP2 and JARID2), little is known about their differential functions...
  11. Kim H, Ekram M, Bakshi A, Kim J. AEBP2 as a transcriptional activator and its role in cell migration. Genomics. 2015;105:108-15 pubmed publisher
    ..Immuno-Precipitation (ChIP) experiments revealed that AEBP2 binds to its own promoter as well as the promoters of Jarid2 and Snai2...
  12. Ferreccio A, Mathieu J, Detraux D, Somasundaram L, Cavanaugh C, Sopher B, et al. Inducible CRISPR genome editing platform in naive human embryonic stem cells reveals JARID2 function in self-renewal. Cell Cycle. 2018;17:535-549 pubmed publisher
    ..We show reduced H3K27me3 and pluripotency markers in JARID2 2iL-I-F hESC mutants, indicating JARID2 requirement in maintenance of hESC 2iL-I-F state...
  13. Landeira D, Sauer S, Poot R, Dvorkina M, Mazzarella L, Jørgensen H, et al. Jarid2 is a PRC2 component in embryonic stem cells required for multi-lineage differentiation and recruitment of PRC1 and RNA Polymerase II to developmental regulators. Nat Cell Biol. 2010;12:618-24 pubmed publisher
    ..Here we show that Jarid2 is a novel subunit of PRC2 that is required for the co-recruitment of PRC1 and RNAP to genes that regulate ..
  14. Yaqubi M, Mohammadnia A, Fallahi H. Predicting involvement of polycomb repressive complex 2 in direct conversion of mouse fibroblasts into induced neural stem cells. Stem Cell Res Ther. 2015;6:42 pubmed publisher
    ..Based on these analyses, we found that Ezh2, Jarid2, Mtf2, Nanog, Pou5f1, Sall4, Smarca4, Sox2, Suz12, and Tcf3 are the main regulators of direct conversion of mouse ..
  15. Dahle Ã, Kuehn M. Inhibiting Smad2/3 signaling in pluripotent mouse embryonic stem cells enhances endoderm formation by increasing transcriptional priming of lineage-specifying target genes. Dev Dyn. 2016;245:807-15 pubmed publisher
    ..Analysis indicates that increased H3K27me3 leads to increased binding of PRC2 accessory component Jarid2 and recruitment of RNA polymerase II...
  16. Yi J, Shen H, Qiu J, Huang M, Zhang W, Ding J, et al. JMJD6 and U2AF65 co-regulate alternative splicing in both JMJD6 enzymatic activity dependent and independent manner. Nucleic Acids Res. 2017;45:3503-3518 pubmed publisher
    JMJD6, a jumonji C (Jmj C) domain-containing protein demethylase and hydroxylase, has been implicated in an array of biological processes...
  17. Oksuz O, Narendra V, Lee C, Descostes N, LeRoy G, Raviram R, et al. Capturing the Onset of PRC2-Mediated Repressive Domain Formation. Mol Cell. 2018;70:1149-1162.e5 pubmed publisher
    ..First, PRC2 is stably recruited by the actions of JARID2 and MTF2 to a limited number of spatially interacting "nucleation sites," creating H3K27me3-forming Polycomb foci ..
  18. Pereira R, Martinez G, Engel I, Cruz Guilloty F, Barboza B, Tsagaratou A, et al. Jarid2 is induced by TCR signalling and controls iNKT cell maturation. Nat Commun. 2014;5:4540 pubmed publisher
    b>Jarid2 is a reported component of three lysine methyltransferase complexes, polycomb repressive complex 2 (PRC2) that methylates histone 3 lysine 27 (H3K27), and GLP-G9a and SETDB1 complexes that methylate H3K9...
  19. Cho E, Mysliwiec M, Carlson C, ANSARI A, Schwartz R, Lee Y. Cardiac-specific developmental and epigenetic functions of Jarid2 during embryonic development. J Biol Chem. 2018;293:11659-11673 pubmed publisher
    Epigenetic regulation is critical in normal cardiac development. We have demonstrated that the deletion of Jarid2 (Jumonji (Jmj) A/T-rich interaction domain 2) in mice results in cardiac malformations recapitulating human ..
  20. Fellous A, Favrel P, Rivière G. Temperature influences histone methylation and mRNA expression of the Jmj-C histone-demethylase orthologues during the early development of the oyster Crassostrea gigas. Mar Genomics. 2015;19:23-30 pubmed publisher
    ..Such investigations could help better understand the molecular mechanisms of development and adaptation in lophotrochozoans. ..
  21. Zuchegna C, Aceto F, Bertoni A, Romano A, Perillo B, Laccetti P, et al. Mechanism of retinoic acid-induced transcription: histone code, DNA oxidation and formation of chromatin loops. Nucleic Acids Res. 2014;42:11040-55 pubmed publisher
    ..and we found that histone H3 lysines 4 and 9 are demethylated by the lysine-specific demethylase, LSD1 and by the JMJ-domain containing demethylase, D2A...
  22. Chowrasia S, Panda A, Rawal H, Kaur H, Mondal T. Identification of jumonjiC domain containing gene family among the Oryza species and their expression analysis in FL478, a salt tolerant rice genotype. Plant Physiol Biochem. 2018;130:43-53 pubmed publisher
    The jumonji (JMJ)-C domain containing proteins belong to histone demethylases family with the ability to demethylate the tri-methylated histone residues. They act as chromatin regulators to regulate many physiological functions in plants...
  23. Adhikari A, Davie J. JARID2 and the PRC2 complex regulate skeletal muscle differentiation through regulation of canonical Wnt signaling. Epigenetics Chromatin. 2018;11:46 pubmed publisher
    b>JARID2 is a non-catalytic member of the polycomb repressive complex 2 (PRC2), which is known to regulate developmental target genes in embryonic stem cells...
  24. Pilka E, James T, Lisztwan J. Structural definitions of Jumonji family demethylase selectivity. Drug Discov Today. 2015;20:743-9 pubmed publisher
    The Jumonji (Jmj) family of demethylases has a crucial role in regulating epigenetic processes through the removal of methyl groups from histone tails...
  25. Gennart I, Coupeau D, Pejaković S, Laurent S, Rasschaert D, Muylkens B. Marek's disease: Genetic regulation of gallid herpesvirus 2 infection and latency. Vet J. 2015;205:339-48 pubmed publisher
    ..Inhibition of expression of the pro-apoptotic factors JARID2 and SMAD2 by viral microRNAs may promote the survival and proliferation of GaHV-2 latently infected cells, thus ..
  26. Burger N, Haak M, Kok E, de Groot C, Shou W, Scambler P, et al. Cardiac defects, nuchal edema and abnormal lymphatic development are not associated with morphological changes in the ductus venosus. Early Hum Dev. 2016;101:39-48 pubmed publisher
    ..embryos), mouse embryos with cardiac defects and nuchal edema (Fkbp12(-/-), Tbx1(-/-), Chd7(fl/fl);Mesp1Cre, Jarid2(-/-NE+) embryos) and mouse embryos with cardiac defects without nuchal edema (Tbx2(-/-), Fgf10(-/-), Jarid2(-/-NE-)..
  27. Li A, Hanchard N, Furthner D, Fernbach S, Azamian M, Nicosia A, et al. Whole exome sequencing in 342 congenital cardiac left sided lesion cases reveals extensive genetic heterogeneity and complex inheritance patterns. Genome Med. 2017;9:95 pubmed publisher
    ..including 9 confirmed de novo variants in both novel and newly described human CVM candidate genes (ACVR1, JARID2, NR2F2, PLRG1, SMURF1) as well as established syndromic CVM genes (KMT2D, NF1, TBX20, ZEB2)...
  28. Qu Y, Yang Q, Liu J, Shi B, Ji M, Li G, et al. c-Myc is Required for BRAFV600E-Induced Epigenetic Silencing by H3K27me3 in Tumorigenesis. Theranostics. 2017;7:2092-2107 pubmed publisher
    ..in H3K27me3 through regulating the components of the polycomb repressive complex 2 (PRC2) genes Ezh2, Suz12 and Jarid2 at both transcriptional levels via direct binding to their regulatory elements and post-transcriptional levels via ..
  29. Nakagawa R, Leyland R, Meyer Hermann M, Lu D, Turner M, Arbore G, et al. MicroRNA-155 controls affinity-based selection by protecting c-MYC+ B cells from apoptosis. J Clin Invest. 2016;126:377-88 pubmed publisher
    ..We determined that miR-155 directly inhibits the Jumonji family member JARID2, which enhances B cell apoptosis when overexpressed, and thereby promotes GC B cell survival...
  30. Zahir F, Tucker T, Mayo S, Brown C, Lim E, Taylor J, et al. Intragenic CNVs for epigenetic regulatory genes in intellectual disability: Survey identifies pathogenic and benign single exon changes. Am J Med Genet A. 2016;170:2916-2926 pubmed publisher
    ..Previously, we found a CNV involving only exon 6 of the JARID2 gene occurred apparently de novo in seven patients...
  31. Grassi D, Franz H, Vezzali R, Bovio P, Heidrich S, Dehghanian F, et al. Neuronal Activity, TGF?-Signaling and Unpredictable Chronic Stress Modulate Transcription of Gadd45 Family Members and DNA Methylation in the Hippocampus. Cereb Cortex. 2017;27:4166-4181 pubmed publisher
    ..Psychiatric disorder-related genes, namely Tshz1, Foxn3, Jarid2, Per1, Map3k5, and Arc are transcriptionally activated and demethylated upon neuronal activation...
  32. Boyd N, Morgan J, Greer S. Polycomb recruitment at the Class II transactivator gene. Mol Immunol. 2015;67:482-91 pubmed publisher
    ..We demonstrate Yin Yang 1 (YY1) and Jumonji domain containing protein 2 (JARID2) are binding partners along with EZH2 in mammalian cells...
  33. Liang D, Li J, Wu Y, Zhen L, Li C, Qi M, et al. miRNA-204 drives cardiomyocyte proliferation via targeting Jarid2. Int J Cardiol. 2015;201:38-48 pubmed publisher
    ..Furthermore, we demonstrated that miRNA-204 directly targeted Jarid2. Knockdown of Jarid2 mimicked the pro-proliferative effect of miRNA-204 overexpression on cultured rat ..
  34. Park S, Park J, Chun Y. Jumonji histone demethylases as emerging therapeutic targets. Pharmacol Res. 2016;105:146-51 pubmed publisher
    ..Jumonji domain-containing histone-lysine demethylases (Jmj-KDMs) remove the methyl moiety from lysine residues in histones by utilizing Fe(2+) and α-ketoglutarate...
  35. Cooper S, Grijzenhout A, Underwood E, Ancelin K, Zhang T, Nesterova T, et al. Jarid2 binds mono-ubiquitylated H2A lysine 119 to mediate crosstalk between Polycomb complexes PRC1 and PRC2. Nat Commun. 2016;7:13661 pubmed publisher
    ..Here we demonstrate a critical role for the PRC2 cofactor Jarid2 in mediating the interaction of PRC2 with H2AK119u1...
  36. Chen S, Jiao L, Shubbar M, Yang X, Liu X. Unique Structural Platforms of Suz12 Dictate Distinct Classes of PRC2 for Chromatin Binding. Mol Cell. 2018;69:840-852.e5 pubmed publisher
    ..Here, we report the crystal structures of a 120 kDa heterotetrameric complex consisting of Suz12, Rbbp4, Jarid2, and Aebp2 fragments that is minimally active in nucleosome binding and of an inactive binary complex of Suz12 and ..
  37. Meseure D, Vacher S, Alsibai K, Nicolas A, Chemlali W, Caly M, et al. Expression of ANRIL-Polycomb Complexes-CDKN2A/B/ARF Genes in Breast Tumors: Identification of a Two-Gene (EZH2/CBX7) Signature with Independent Prognostic Value. Mol Cancer Res. 2016;14:623-33 pubmed publisher
    ..Expression analysis of ANRIL, EZH2, SUZ12, EED, JARID2, CBX7, BMI1, p16, p15, and p14/ARF genes was evaluated in a large cohort of invasive breast carcinomas (IBC, n = ..
  38. Slezak Prochazka I, Kluiver J, de Jong D, Smigielska Czepiel K, Kortman G, Winkle M, et al. Inhibition of the miR-155 target NIAM phenocopies the growth promoting effect of miR-155 in B-cell lymphoma. Oncotarget. 2016;7:2391-400 pubmed publisher
    ..miR-155-specific target genes in BL cells and confirmed miR-155 targeting of DET1, NIAM, TRIM32, HOMEZ, PSIP1 and JARID2. Five of these targets are also regulated by endogenous miR-155 in HL cells...
  39. Preuss C, Capredon M, Wünnemann F, Chetaille P, Prince A, Godard B, et al. Family Based Whole Exome Sequencing Reveals the Multifaceted Role of Notch Signaling in Congenital Heart Disease. PLoS Genet. 2016;12:e1006335 pubmed publisher
    ..These rare or novel protein altering mutations cluster predominantly in genes (NOTCH1, ARHGAP31, MAML1, SMARCA4, JARID2, JAG1) along the Notch signaling cascade. This is in line with a significant enrichment (Wilcoxon, p< 0...
  40. Basu Mallik S, Pai A, Shenoy R, Jayashree B. Novel flavonol analogues as potential inhibitors of JMJD3 histone demethylase-A study based on molecular modelling. J Mol Graph Model. 2017;72:81-87 pubmed publisher
    ..Since their discovery, Jmj-C histone demethylases were identified as useful markers in understanding the role of epigenetics in inflammatory ..
  41. Iseki H, Nakachi Y, Hishida T, Yamashita Sugahara Y, Hirasaki M, Ueda A, et al. Combined Overexpression of JARID2, PRDM14, ESRRB, and SALL4A Dramatically Improves Efficiency and Kinetics of Reprogramming to Induced Pluripotent Stem Cells. Stem Cells. 2016;34:322-33 pubmed publisher
    ..that the efficiency and kinetics of iPSC reprogramming are dramatically improved by the combined expression of Jarid2 and genes encoding its associated proteins...
  42. Fei Q, Yang X, Jiang H, Wang Q, Yu Y, Yu Y, et al. SETDB1 modulates PRC2 activity at developmental genes independently of H3K9 trimethylation in mouse ES cells. Genome Res. 2015;25:1325-35 pubmed publisher
    ..genes, was found to be associated with Polycomb Repressive Complex 2 (PRC2) as well as PRC2-interacting proteins JARID2 and MTF2...
  43. Terashima M, Tange S, Ishimura A, Suzuki T. MEG3 Long Noncoding RNA Contributes to the Epigenetic Regulation of Epithelial-Mesenchymal Transition in Lung Cancer Cell Lines. J Biol Chem. 2017;292:82-99 pubmed publisher
    ..the molecular mechanism for the recruitment of Polycomb repressive complex-2 (PRC2) and its accessory component, JARID2, to chromatin, which regulates methylation of lysine 27 of histone H3 (H3K27), during epithelial-mesenchymal ..
  44. Kasinath V, Faini M, Poepsel S, Reif D, Feng X, Stjepanovic G, et al. Structures of human PRC2 with its cofactors AEBP2 and JARID2. Science. 2018;359:940-944 pubmed publisher
    ..structures of human PRC2 in a basal state and two distinct active states while in complex with its cofactors JARID2 and AEBP2. Both cofactors mimic the binding of histone H3 tails...
  45. Kabelitz T, Brzezinka K, Friedrich T, Górka M, Graf A, Kappel C, et al. A JUMONJI Protein with E3 Ligase and Histone H3 Binding Activities Affects Transposon Silencing in Arabidopsis. Plant Physiol. 2016;171:344-58 pubmed publisher
    ..JUMONJI (JMJ) proteins can function as antisilencing factors and prevent silencing of genes next to TEs Whether TE silencing is ..
  46. Landeira D, Bağci H, Malinowski A, Brown K, Soza Ried J, Feytout A, et al. Jarid2 Coordinates Nanog Expression and PCP/Wnt Signaling Required for Efficient ESC Differentiation and Early Embryo Development. Cell Rep. 2015;12:573-86 pubmed publisher
    b>Jarid2 is part of the Polycomb Repressor complex 2 (PRC2) responsible for genome-wide H3K27me3 deposition...
  47. Lee Y, Song A, Baker R, Micales B, Conway S, Lyons G. Jumonji, a nuclear protein that is necessary for normal heart development. Circ Res. 2000;86:932-8 pubmed
    Jumonji (jmj) was cloned in a gene trap screen to identify and mutagenize genes important for heart development. To investigate the role of jmj in heart development, we generated mice homozygous for the jmj mutation...
  48. Zhu X, Yan Y, Ai C, Jiang S, Xu S, Niu M, et al. Jarid2 is essential for the maintenance of tumor initiating cells in bladder cancer. Oncotarget. 2017;8:24483-24490 pubmed publisher
    ..However, the molecular and genetic mechanisms regulating TICs in bladder cancer remain poorly defined. Jarid2 is implicated in signaling pathways regulating cancer cell epithelial-mesenchymal transition, and stem cell ..
  49. Basu M, Zhu J, Lahaye S, Majumdar U, Jiao K, Han Z, et al. Epigenetic mechanisms underlying maternal diabetes-associated risk of congenital heart disease. JCI Insight. 2017;2: pubmed publisher
    ..Transcription of Jarid2, a regulator of histone methyltransferase complexes, was increased in response to reduced NO, and this ..
  50. Barøy T, Misceo D, Strømme P, Stray Pedersen A, Holmgren A, Rødningen O, et al. Haploinsufficiency of two histone modifier genes on 6p22.3, ATXN1 and JARID2, is associated with intellectual disability. Orphanet J Rare Dis. 2013;8:3 pubmed publisher
    ..We suggest JARID2 and ATXN1, both harbored in 6p22.3, as disease causing genes...
  51. Lei X, Xu J, Chang R, Fang F, Zuo C, Yang L. JARID2 promotes invasion and metastasis of hepatocellular carcinoma by facilitating epithelial-mesenchymal transition through PTEN/AKT signaling. Oncotarget. 2016;7:40266-40284 pubmed publisher
    b>JARID2 is crucial for maintenance of pluripotency and differentiation of embryonic stem cells. However, little is known about the role of JARID2 in metastasis of hepatocellular carcinoma (HCC)...
  52. Bovill E, Westaby S, Reji S, Sayeed R, Crisp A, Shaw T. Induction by left ventricular overload and left ventricular failure of the human Jumonji gene (JARID2) encoding a protein that regulates transcription and reexpression of a protective fetal program. J Thorac Cardiovasc Surg. 2008;136:709-16 pubmed publisher
    We identified changes in Jumonji (JARID2) expression in failing human hearts and determined its effects on expressions of atrial natriuretic factor (ANF), myosin light chain 2a (MLC2A), and alpha myosin heavy chain (MHCA), genes ..
  53. Xu M, Zuo D, Liu X, Fan H, Chen Q, Deng S, et al. MiR-155 contributes to Th17 cells differentiation in dextran sulfate sodium (DSS)-induced colitis mice via Jarid2. Biochem Biophys Res Commun. 2017;488:6-14 pubmed publisher
    ..Firstly, through bioinformatics analysis and luciferase report assay, we found Jarid2 was a direct target of miR-155; then, we carried out in situ hybridization, immunofluorescence and flow cytometry, ..
  54. Kinkel S, Galeev R, Flensburg C, Keniry A, Breslin K, Gilan O, et al. Jarid2 regulates hematopoietic stem cell function by acting with polycomb repressive complex 2. Blood. 2015;125:1890-900 pubmed publisher
    ..We find that, similar to the phenotype observed upon depletion of core subunit Suz12, depleting Jarid2 enhances the competitive transplantation capacity of both fetal and adult mouse HSPCs...
  55. Berge Lefranc J, Jay P, Massacrier A, Cau P, Mattei M, Bauer S, et al. Characterization of the human jumonji gene. Hum Mol Genet. 1996;5:1637-41 pubmed
    ..We have determined the complete coding sequence of the human homologue (JMJ) and deduced the amino acid sequence of the putative protein...
  56. Jiang Y, Chen Y, Chen Y. Knockdown of JARID2 inhibits the viability and migration of placenta trophoblast cells in preeclampsia. Mol Med Rep. 2017;16:3594-3599 pubmed publisher
    b>Protein Jumonji (JARID2) is a member of the Jumonji family of proteins and has been demonstrated to regulate cell proliferation and invasion...
  57. Wang X, Paucek R, Gooding A, Brown Z, Ge E, Muir T, et al. Molecular analysis of PRC2 recruitment to DNA in chromatin and its inhibition by RNA. Nat Struct Mol Biol. 2017;: pubmed publisher
    ..Histone modifications, the H3K27M cancer mutation, and inclusion of JARID2 or EZH1 in the PRC2 complex have unexpectedly minor effects on PRC2-nucleosome binding...
  58. Pedrosa E, Ye K, Nolan K, Morrell L, Okun J, Persky A, et al. Positive association of schizophrenia to JARID2 gene. Am J Med Genet B Neuropsychiatr Genet. 2007;144B:45-51 pubmed
    ..However, so far, no disease-causing alleles have been identified. DTNBP1 is immediately adjacent to JARID2, a member of the ARID (AT-rich interaction domain) family of transcription modulators...
  59. Cao J, Li H, Liu G, Han S, Xu P. Knockdown of JARID2 inhibits the proliferation and invasion of ovarian cancer through the PI3K/Akt signaling pathway. Mol Med Rep. 2017;16:3600-3605 pubmed publisher
    b>Protein Jumonji (JARID2), a member of the family of JmjC domain-containing proteins, has been reported to serve an important role in tumor growth and metastasis...
  60. Zhang S, Xie Y, Cao H, Wang H. Common microRNA-mRNA interactions exist among distinct porcine iPSC lines independent of their metastable pluripotent states. Cell Death Dis. 2017;8:e3027 pubmed publisher
    ..pluripotent genes (OCT4, SOX2, NANOG, SALL4 and ESRRB) and upregulation of differentiation relevant genes (SOX9, JARID2 and JMJD4). Moreover, these phenotypes caused by miR-370 could be rescued by overexpressing LIN28A...
  61. Cervantes S, Fontcuberta PiSunyer M, Servitja J, Fernandez Ruiz R, García A, Sanchez L, et al. Late-stage differentiation of embryonic pancreatic β-cells requires Jarid2. Sci Rep. 2017;7:11643 pubmed publisher
    b>Jarid2 is a component of the Polycomb Repressor complex 2 (PRC2), which is responsible for genome-wide H3K27me3 deposition, in embryonic stem cells...
  62. Messetti A, Machado R, de Oliveira C, Martelli Júnior H, de Almeida Reis S, Moreira H, et al. Brazilian multicenter study of association between polymorphisms in CRISPLD2 and JARID2 and non-syndromic oral clefts. J Oral Pathol Med. 2017;46:232-239 pubmed publisher
    ..secretory protein LCCL domain containing 2 gene (CRISPLD2) and in the jumonji, AT-rich interaction domain 2 gene (JARID2) were previously shown to influence non-syndromic oral cleft susceptibility...
  63. Volcik K, Zhu H, Finnell R, Shaw G, Canfield M, Lammer E. Evaluation of the jumonji gene and risk for spina bifida and congenital heart defects. Am J Med Genet A. 2004;126A:215-7 pubmed
  64. Liu Y, Chen G, Norton N, Liu W, Zhu H, Zhou P, et al. Whole genome association study in a homogenous population in Shandong peninsula of China reveals JARID2 as a susceptibility gene for schizophrenia. J Biomed Biotechnol. 2009;2009:536918 pubmed publisher
    ..Association of D6S289, a dinucleotide repeat polymorphism in the JARID2 gene with SZ, was found and confirmed by individual genotyping (X(2) = 17.89; P = .047)...
  65. Vijai J, Kirchhoff T, Schrader K, Brown J, Dutra Clarke A, Manschreck C, et al. Susceptibility loci associated with specific and shared subtypes of lymphoid malignancies. PLoS Genet. 2013;9:e1003220 pubmed publisher
    ..These results, showing novel susceptibility regions and allelic heterogeneity, point to the existence of pathways of susceptibility to both shared as well as specific subtypes of lymphoid malignancy. ..
  66. Gilbert K, Blossom S, Reisfeld B, Erickson S, Vyas K, Maher M, et al. Trichloroethylene-induced alterations in DNA methylation were enriched in polycomb protein binding sites in effector/memory CD4+ T cells. Environ Epigenet. 2017;3: pubmed publisher
    ..sites occurred in regions known to bind one or more Polycomb group (PcG) proteins, namely Ezh2, Suz12, Mtf2 or Jarid2. In comparison, only 23...
  67. Escobar T, Kanellopoulou C, Kugler D, Kilaru G, Nguyen C, Nagarajan V, et al. miR-155 activates cytokine gene expression in Th17 cells by regulating the DNA-binding protein Jarid2 to relieve polycomb-mediated repression. Immunity. 2014;40:865-79 pubmed publisher
    ..miR-155-deficient Th17 and T regulatory (Treg) cells expressed increased amounts of Jarid2, a DNA-binding protein that recruits the Polycomb Repressive Complex 2 (PRC2) to chromatin...
  68. Hao Y, Mi N, Jiao X, Zheng X, Song T, Zhuang D, et al. Association of JARID2 polymorphisms with non-syndromic orofacial clefts in northern Chinese Han population. J Oral Pathol Med. 2015;44:386-91 pubmed publisher
    ..Recently, the jumoji AT-rich interaction domain 2 (JARID2) had been reported to be a novel candidate gene for non-syndromic cleft lip with or without cleft palate (CL/P)...
  69. Singh B, Tahara N, Kawakami Y, Das S, Koyano Nakagawa N, Gong W, et al. Etv2-miR-130a-Jarid2 cascade regulates vascular patterning during embryogenesis. PLoS ONE. 2017;12:e0189010 pubmed publisher
    ..Mechanistically, miR-130a directly regulated Jarid2 expression by binding to its 3'-UTR region...
  70. Mo W, Liu J, Zhang Z, Yu H, Yang A, Qu F, et al. A study of single nucleotide polymorphisms in CD157, AIM2 and JARID2 genes in Han Chinese children with autism spectrum disorder. Nord J Psychiatry. 2017;:1-5 pubmed publisher
    ..The objective of this study was to investigate whether single nucleotide polymorphisms (SNPs) in genes related to immune function were associated with ASD in Chinese Han children...
  71. Li Z, Xu C, Gao M, Ding B, Wei X, Ji N. Reduced Expression of Jumonji AT-Rich Interactive Domain 2 (JARID2) in Glioma Inhibits Tumor Growth In Vitro and In Vivo. Oncol Res. 2017;25:365-372 pubmed publisher
    Jumonji AT-rich interactive domain 2 (JARID2) is a member of the Jumonji family of proteins and has been proposed as an oncogene in several types of human cancer. However, the role of JARID2 in human glioma has not yet been understood...
  72. Sanulli S, Justin N, Teissandier A, Ancelin K, Portoso M, Caron M, et al. Jarid2 Methylation via the PRC2 Complex Regulates H3K27me3 Deposition during Cell Differentiation. Mol Cell. 2015;57:769-83 pubmed publisher
    ..b>Jarid2 was previously identified as a cofactor of PRC2, regulating PRC2 targeting to chromatin and its enzymatic activity...
  73. An M, Kim C, Nam G, Kim D, Rhee S, Cho S, et al. Transcriptome analysis for UVB-induced phototoxicity in mouse retina. Environ Toxicol. 2018;33:52-62 pubmed publisher
    ..signaling (eg, Creb3, Ddrgk1, Grin1, Map7, Uqcc2, Uqcrb), regulation of chromatin and gene expression (eg, Chd5, Jarid2, Kat6a, Smarcc2, Sumo1, Zfp84), transcription factors (eg, Asxl2, Atf7, Per1, Phox2a, Rxra), RNA processing, and ..
  74. Toyoda M, Kojima M, Takeuchi T. Jumonji is a nuclear protein that participates in the negative regulation of cell growth. Biochem Biophys Res Commun. 2000;274:332-6 pubmed
    The jumonji (jmj) gene, obtained by a gene trap strategy, is essential for mouse embryogenesis and is suggested to play important roles in cell growth during development...
  75. Tange S, Oktyabri D, Terashima M, Ishimura A, Suzuki T. JARID2 is involved in transforming growth factor-beta-induced epithelial-mesenchymal transition of lung and colon cancer cell lines. PLoS ONE. 2014;9:e115684 pubmed publisher
    ..In this study, we discovered that JARID2, an interacting component of Polycomb repressive complex-2 (PRC2) that catalyzes methylation of lysine 27 of ..
  76. Liang D, Xu X, Deng F, Feng J, Zhang H, Liu Y, et al. miRNA-940 reduction contributes to human Tetralogy of Fallot development. J Cell Mol Med. 2014;18:1830-9 pubmed publisher
    ..miRNA-940 reduction significantly promoted hCMPCs proliferation and inhibited hCMPCs migration. We found that JARID2 is an endogenous target regulated by miRNA-940...
  77. Suong D, Shimaji K, Pyo J, Park J, Yoshida H, Yoo M, et al. Overexpression of dJmj differentially affects intestinal stem cells and differentiated enterocytes. Cell Signal. 2018;42:194-210 pubmed publisher
    Jumonji (Jmj)/Jarid2 is a DNA-binding transcriptional repressor mediated via histone methylation...
  78. Shirato H, Ogawa S, Nakajima K, Inagawa M, Kojima M, Tachibana M, et al. A jumonji (Jarid2) protein complex represses cyclin D1 expression by methylation of histone H3-K9. J Biol Chem. 2009;284:733-9 pubmed publisher
    ..Previously, we identified the jumonji (jmj, Jarid2) gene, the jmjC domain, and a Jmj family...
  79. Su C, Deng T, Shang Z, Xiao Y. JARID2 inhibits leukemia cell proliferation by regulating CCND1 expression. Int J Hematol. 2015;102:76-85 pubmed publisher
    It has recently been shown that JARID2 contributes to the malignant character of solid tumors, such as epithelial-mesenchymal transition in lung and colon cancer cell lines, but its role in leukemia progression is unexplored...
  80. Sahu M, Mallick B. An integrative approach predicted co-expression sub-networks regulating properties of stem cells and differentiation. Comput Biol Chem. 2016;64:250-262 pubmed publisher
    ..hypothesize that FGF2 is contributing to pluripotent transcription network of hESCs in association with DNMT3B and JARID2 thereby facilitating cell proliferation...
  81. Mayer R, Schwarzmeier J, Gerner M, Bileck A, Mader J, Meier Menches S, et al. Proteomics and metabolomics identify molecular mechanisms of aging potentially predisposing for chronic lymphocytic leukemia. Mol Cell Proteomics. 2018;17:290-303 pubmed publisher
    ..In B-CLL cells, some remarkable unique features like the loss of tumor suppressor molecules PNN and JARID2, the stress-related serotonin transporter SLC6A4, and high expression of ZNF207, CCDC88A, PIGR and ID3, otherwise ..
  82. Zhao Q, Liao R, Sun H, Zhang Z, Wang Q, Yang C, et al. Identifying Genetic Differences Between Dongxiang Blue-Shelled and White Leghorn Chickens Using Sequencing Data. G3 (Bethesda). 2018;8:469-476 pubmed publisher
    ..We show that the White Leghorn genes JARID2, RBMS3, GPC3, TRIB2, ROBO1, SAMSN1, OSBP2, and IGFALS are ..
  83. Schuh Huerta S, Johnson N, Rosen M, Sternfeld B, Cedars M, Reijo Pera R. Genetic variants and environmental factors associated with hormonal markers of ovarian reserve in Caucasian and African American women. Hum Reprod. 2012;27:594-608 pubmed publisher
    ..The discovery of genetic markers may lead to better long-range predictions of declining ovarian function, with implications for reproductive and somatic health. ..