JAGGED1

Summary

Gene Symbol: JAGGED1
Description: jagged 1
Alias: AGS, AGS1, AHD, AWS, CD339, HJ1, JAGL1, protein jagged-1
Species: human
Products:     JAGGED1

Top Publications

  1. Li L, Milner L, Deng Y, Iwata M, Banta A, Graf L, et al. The human homolog of rat Jagged1 expressed by marrow stroma inhibits differentiation of 32D cells through interaction with Notch1. Immunity. 1998;8:43-55 pubmed
    A cDNA clone encoding the human homolog of rat Jagged1 was isolated from normal human marrow...
  2. Guarnaccia C, Pintar A, Pongor S. Exon 6 of human Jagged-1 encodes an autonomously folding unit. FEBS Lett. 2004;574:156-60 pubmed
    ..We show that it is structured in solution, as suggested by circular dichroism and NMR spectroscopy, and displays an EGF-like disulfide bond topology, as determined by disulfide mapping. ..
  3. Santagata S, Demichelis F, Riva A, Varambally S, Hofer M, Kutok J, et al. JAGGED1 expression is associated with prostate cancer metastasis and recurrence. Cancer Res. 2004;64:6854-7 pubmed
    ..Here we show that JAGGED1, a NOTCH receptor ligand, is significantly more highly expressed in metastatic prostate cancer as compared with ..
  4. Zeng Q, Li S, Chepeha D, Giordano T, Li J, Zhang H, et al. Crosstalk between tumor and endothelial cells promotes tumor angiogenesis by MAPK activation of Notch signaling. Cancer Cell. 2005;8:13-23 pubmed
    ..Here, we report that the Notch ligand Jagged1 induced by growth factors via mitogen-activating protein kinase (MAPK) in head and neck squamous cell carcinoma (..
  5. Shimizu K, Chiba S, Saito T, Kumano K, Takahashi T, Hirai H. Manic fringe and lunatic fringe modify different sites of the Notch2 extracellular region, resulting in different signaling modulation. J Biol Chem. 2001;276:25753-8 pubmed
    ..Although both manic fringe (mFng) and lunatic fringe (lFng) decreased the binding of Jagged1 to Notch2 and not that of Delta1, the decrease by mFng was greater in degree than that by lFng...
  6. Röpke A, Kujat A, Gräber M, Giannakudis J, Hansmann I. Identification of 36 novel Jagged1 (JAG1) mutations in patients with Alagille syndrome. Hum Mutat. 2003;21:100 pubmed
    ..The previously described Jagged1 (JAG1) gene on chromosome 20p12 has been identified as being responsible for AGS...
  7. Pilia G, Uda M, Macis D, Frau F, Crisponi L, Balli F, et al. Jagged-1 mutation analysis in Italian Alagille syndrome patients. Hum Mutat. 1999;14:394-400 pubmed
    Alagille syndrome (AGS) is an autosomal dominant disorder with developmental abnormalities affecting the liver, heart, eyes, vertebrae, and craniofacial region...
  8. Jurkiewicz D, Popowska E, Gläser C, Hansmann I, Krajewska Walasek M. Twelve novel JAG1 gene mutations in Polish Alagille syndrome patients. Hum Mutat. 2005;25:321 pubmed
    Alagille syndrome (AGS) is an autosomal dominant disorder with developmental abnormalities of the liver, heart, eyes, vertebrae, and face...
  9. Whiteman P, de Madrid B, Taylor P, Li D, Heslop R, Viticheep N, et al. Molecular basis for Jagged-1/Serrate ligand recognition by the Notch receptor. J Biol Chem. 2013;288:7305-12 pubmed publisher
    ..As a proof of principle, we have generated a Notch-1-specific monoclonal antibody that blocks binding, thus paving the way for antibody tools for research and therapeutic applications. ..

More Information

Publications83

  1. Ascano J, Beverly L, Capobianco A. The C-terminal PDZ-ligand of JAGGED1 is essential for cellular transformation. J Biol Chem. 2003;278:8771-9 pubmed
    b>JAGGED1 is a member of the Delta/Serrate/Lag-2 (DSL) family of proteins that are cell-bound ligands for Notch receptors...
  2. Choi J, Park J, Davidson B, Morin P, Shih I, Wang T. Jagged-1 and Notch3 juxtacrine loop regulates ovarian tumor growth and adhesion. Cancer Res. 2008;68:5716-23 pubmed publisher
  3. Skrtic A, Korac P, Krišto D, Ajduković Stojisavljević R, Ivankovic D, Dominis M. Immunohistochemical analysis of NOTCH1 and JAGGED1 expression in multiple myeloma and monoclonal gammopathy of undetermined significance. Hum Pathol. 2010;41:1702-10 pubmed publisher
    ..is implicated in the pathogenesis of multiple myeloma expressing high level of active Notch proteins NOTCH1 and JAGGED1 in tumor plasma cells...
  4. Small D, Kovalenko D, Kacer D, Liaw L, Landriscina M, Di Serio C, et al. Soluble Jagged 1 represses the function of its transmembrane form to induce the formation of the Src-dependent chord-like phenotype. J Biol Chem. 2001;276:32022-30 pubmed
  5. Cordle J, Johnson S, Tay J, Roversi P, Wilkin M, de Madrid B, et al. A conserved face of the Jagged/Serrate DSL domain is involved in Notch trans-activation and cis-inhibition. Nat Struct Mol Biol. 2008;15:849-57 pubmed publisher
    ..Our data imply that cis- and trans-regulation may occur through the formation of structurally distinct complexes that, unexpectedly, involve the same surfaces on both ligand and receptor. ..
  6. Warthen D, Moore E, Kamath B, Morrissette J, Sanchez Lara P, Sanchez P, et al. Jagged1 (JAG1) mutations in Alagille syndrome: increasing the mutation detection rate. Hum Mutat. 2006;27:436-43 pubmed
    Alagille syndrome (AGS) is caused by heterozygous mutations in JAG1, and mutations have been previously reported in about 70% of patients who meet clinical diagnostic criteria...
  7. Shimizu K, Chiba S, Saito T, Kumano K, Hirai H. Physical interaction of Delta1, Jagged1, and Jagged2 with Notch1 and Notch3 receptors. Biochem Biophys Res Commun. 2000;276:385-9 pubmed
    The Delta/Serrate/LAG-2 (DSL) domain-containing proteins, Delta1, Jagged1, and Jagged2, are considered to be ligands for Notch receptors...
  8. Li L, Krantz I, Deng Y, Genin A, Banta A, Collins C, et al. Alagille syndrome is caused by mutations in human Jagged1, which encodes a ligand for Notch1. Nat Genet. 1997;16:243-51 pubmed
    ..We have mapped the human Jagged1 gene (JAG1), encoding a ligand for the developmentally important Notch transmembrane receptor, to the Alagille ..
  9. Lu J, Ye X, Fan F, Xia L, Bhattacharya R, Bellister S, et al. Endothelial cells promote the colorectal cancer stem cell phenotype through a soluble form of Jagged-1. Cancer Cell. 2013;23:171-85 pubmed publisher
    ..Collectively, ECs play an active role in promoting Notch signaling and the CSC phenotype by secreting soluble Jagged-1. ..
  10. Siar C, Nakano K, Ng K, Tomida M, Nagatsuka H, Kawakami T. Squamous odontogenic tumor of the mandible: a case report demonstrating immunoexpression of Notch1, 3, 4, Jagged1 and Delta1. Eur J Med Res. 2010;15:180-4 pubmed
    ..reactivity of varying intensity in the neoplastic epithelial cells for Notch1, Notch3, Notch4, and their ligands Jagged1 and Delta1. Expression patterns showed considerable overlap...
  11. Johnston D, Dong B, Hughes C. TNF induction of jagged-1 in endothelial cells is NFkappaB-dependent. Gene. 2009;435:36-44 pubmed publisher
    ..Full promoter activity also depends on an AP-1 site at -2.0 kb. These results indicate that canonical NFkappaB signaling is required for TNF induction of the notch ligand jagged-1 in EC. ..
  12. Steg A, Katre A, Goodman B, Han H, Nick A, Stone R, et al. Targeting the notch ligand JAGGED1 in both tumor cells and stroma in ovarian cancer. Clin Cancer Res. 2011;17:5674-85 pubmed publisher
    b>Jagged1, a Notch ligand, is expressed on both tumor epithelial and endothelial cells and therefore may be amenable to dual targeting of the tumor stroma and malignant cell compartments of the tumor microenvironment...
  13. Colliton R, Bason L, Lu F, Piccoli D, Krantz I, Spinner N. Mutation analysis of Jagged1 (JAG1) in Alagille syndrome patients. Hum Mutat. 2001;17:151-2 pubmed
    Alagille syndrome (AGS) is an autosomal dominant disorder caused by mutations in Jagged1 (JAG1), a ligand in the evolutionarily conserved Notch signaling pathway...
  14. Guegan K, Stals K, Day M, Turnpenny P, Ellard S. JAG1 mutations are found in approximately one third of patients presenting with only one or two clinical features of Alagille syndrome. Clin Genet. 2012;82:33-40 pubmed publisher
  15. Kim M, Jung J, Mo J, Ann E, Ahn J, Yoon J, et al. The intracellular domain of Jagged-1 interacts with Notch1 intracellular domain and promotes its degradation through Fbw7 E3 ligase. Exp Cell Res. 2011;317:2438-46 pubmed publisher
    ..These results indicate that JICD functions as a negative regulator in Notch1 signaling via the promotion of Notch1-IC degradation. ..
  16. Jundt F, Pröbsting K, Anagnostopoulos I, Muehlinghaus G, Chatterjee M, Mathas S, et al. Jagged1-induced Notch signaling drives proliferation of multiple myeloma cells. Blood. 2004;103:3511-5 pubmed
    ..Here we demonstrate that Notch receptors and their ligand Jagged1 are highly expressed in cultured and primary MM cells, whereas nonneoplastic counterparts show low to ..
  17. Panin V, Shao L, Lei L, Moloney D, Irvine K, Haltiwanger R. Notch ligands are substrates for protein O-fucosyltransferase-1 and Fringe. J Biol Chem. 2002;277:29945-52 pubmed
    ..Indeed, O-fucose on mammalian Delta 1 and Jagged1 can be elongated with Manic Fringe in vivo, and Drosophila Delta and Serrate are substrates for Drosophila Fringe ..
  18. Lindsell C, Shawber C, Boulter J, Weinmaster G. Jagged: a mammalian ligand that activates Notch1. Cell. 1995;80:909-17 pubmed
    ..Our data support the hypothesis that Notch-ligand interactions function in maintaining mammalian cells in an undifferentiated state. ..
  19. Heritage M, MacMillan J, Anderson G. DHPLC mutation analysis of Jagged1 (JAG1) reveals six novel mutations in Australian alagille syndrome patients. Hum Mutat. 2002;20:481 pubmed
    ..Mutations in the Jagged1 gene have been found to result in the AGS phenotype...
  20. Oda T, Elkahloun A, Pike B, Okajima K, Krantz I, Genin A, et al. Mutations in the human Jagged1 gene are responsible for Alagille syndrome. Nat Genet. 1997;16:235-42 pubmed
    ..Within this region we identified JAG1, the human homologue of rat Jagged1, which encodes a ligand for the Notch receptor...
  21. Wang H, Wang X, Li Q, Chen S, Liu L, Wei Z, et al. Analysis of JAG1 gene variant in Chinese patients with Alagille syndrome. Gene. 2012;499:191-3 pubmed publisher
    Alagille syndrome (AGS) is an autosomal dominant disorder characterized by bile duct paucity...
  22. Gray G, Mann R, Mitsiadis E, Henrique D, Carcangiu M, Banks A, et al. Human ligands of the Notch receptor. Am J Pathol. 1999;154:785-94 pubmed
    ..have cloned and analyzed the expression of three human homologues of the Notch ligands Delta and Serrate, human Jagged1 (HJ1), human Jagged2 (HJ2), and human Delta1 (H-Delta-1), and determined their chromosomal localizations...
  23. LaVoie M, Selkoe D. The Notch ligands, Jagged and Delta, are sequentially processed by alpha-secretase and presenilin/gamma-secretase and release signaling fragments. J Biol Chem. 2003;278:34427-37 pubmed
    ..Thus, Notch and its cognate ligands are processed by the same molecular machinery and may antagonistically regulate each other's signaling. ..
  24. Heritage M, MacMillan J, Colliton R, Genin A, Spinner N, Anderson G. Jagged1 (JAG1) mutation detection in an Australian Alagille syndrome population. Hum Mutat. 2000;16:408-16 pubmed
    ..Mutations in the Jagged1 gene (JAG1) have been found to result in the AGS phenotype and both protein truncating mutations and missense ..
  25. Hock B, Böhme B, Karn T, Yamamoto T, Kaibuchi K, Holtrich U, et al. PDZ-domain-mediated interaction of the Eph-related receptor tyrosine kinase EphB3 and the ras-binding protein AF6 depends on the kinase activity of the receptor. Proc Natl Acad Sci U S A. 1998;95:9779-84 pubmed
  26. Crosnier C, Driancourt C, Raynaud N, Hadchouel M, Meunier Rotival M. Fifteen novel mutations in the JAGGED1 gene of patients with Alagille syndrome. Hum Mutat. 2001;17:72-3 pubmed
    Mutations in the human JAGGED1 gene cause Alagille syndrome, an autosomal dominant developmental disorder. The gene encodes a transmembrane protein which is a ligand of Notch receptors...
  27. Bash J, Zong W, Banga S, Rivera A, Ballard D, Ron Y, et al. Rel/NF-kappaB can trigger the Notch signaling pathway by inducing the expression of Jagged1, a ligand for Notch receptors. EMBO J. 1999;18:2803-11 pubmed
    b>Jagged1 belongs to the DSL family of ligands for Notch receptors that control the proliferation and differentiation of various cell lineages. However, little is known about the transcription factors that regulate its expression...
  28. Le Friec G, Sheppard D, Whiteman P, Karsten C, Shamoun S, Laing A, et al. The CD46-Jagged1 interaction is critical for human TH1 immunity. Nat Immunol. 2012;13:1213-21 pubmed publisher
    ..Here we identified the Notch family member Jagged1 as a physiological ligand for CD46...
  29. Shimizu M, Cohen B, Goldvasser P, Berman H, Virtanen C, Reedijk M. Plasminogen activator uPA is a direct transcriptional target of the JAG1-Notch receptor signaling pathway in breast cancer. Cancer Res. 2011;71:277-86 pubmed publisher
    ..These data suggest that JAG1-induced Notch activation results in breast cancer progression through upregulation of the plasminogen activator system, directly linking these 2 important pathways of poor prognosis. ..
  30. Crosnier C, Driancourt C, Raynaud N, Dhorne Pollet S, Pollet N, Bernard O, et al. Mutations in JAGGED1 gene are predominantly sporadic in Alagille syndrome. Gastroenterology. 1999;116:1141-8 pubmed
    Mutations in the JAGGED1 gene are responsible for the Alagille syndrome, an autosomal dominant disorder characterized by neonatal jaundice, intrahepatic cholestasis, and developmental disorders affecting the liver, heart, vertebrae, eyes,..
  31. Shimizu K, Chiba S, Kumano K, Hosoya N, Takahashi T, Kanda Y, et al. Mouse jagged1 physically interacts with notch2 and other notch receptors. Assessment by quantitative methods. J Biol Chem. 1999;274:32961-9 pubmed
    ..In this study, we cloned a cDNA for mouse Jagged1 (mJagged1)...
  32. Harendza S, Hübner C, Gläser C, Burdelski M, Thaiss F, Hansmann I, et al. Renal failure and hypertension in Alagille syndrome with a novel JAG1 mutation. J Nephrol. 2005;18:312-7 pubmed
    ..The patient's daughter suffered from severe paucity of intrahepatic bile ducts and received a liver transplant at the age of two years. These findings are discussed including a review of the literature...
  33. Tateya T, Sakamoto S, Imayoshi I, Kageyama R. In vivo overactivation of the Notch signaling pathway in the developing cochlear epithelium. Hear Res. 2015;327:209-17 pubmed publisher
    ..Thus, an appropriate level of Notch signaling is needed for the normal extension of the cochlear epithelium and for differentiation of both hair cells and supporting cells. ..
  34. Herold N, Rudd S, Sanjiv K, Kutzner J, Myrberg I, Paulin C, et al. With me or against me: Tumor suppressor and drug resistance activities of SAMHD1. Exp Hematol. 2017;52:32-39 pubmed publisher
    ..Mutations in SAMHD1 have been associated with the hyperinflammatory disease Aicardi-Goutières syndrome (AGS)...
  35. Cohen B, Shimizu M, Izrailit J, Ng N, Buchman Y, Pan J, et al. Cyclin D1 is a direct target of JAG1-mediated Notch signaling in breast cancer. Breast Cancer Res Treat. 2010;123:113-24 pubmed publisher
    ..Furthermore, we show that cyclin D1 and JAG1 expression correlate in TN breast cancer expression datasets. These data suggest a model whereby JAG1 promotes cyclin D1-mediated proliferation of TN breast cancers. ..
  36. Granja A, Leal E, Pignatelli J, Castro R, Abós B, Kato G, et al. Identification of Teleost Skin CD8α+ Dendritic-like Cells, Representing a Potential Common Ancestor for Mammalian Cross-Presenting Dendritic Cells. J Immunol. 2015;195:1825-37 pubmed publisher
    ..In mice, DCs expressing CD8α(+) in lymphoid tissues have the capacity to cross-present extracellular Ags to T cells through MHC I, similarly to tissue-derived CD103(+) DCs and the human CD141(+) DC population...
  37. Riteau N, Radtke A, Shenderov K, Mittereder L, Oland S, Hieny S, et al. Water-in-Oil-Only Adjuvants Selectively Promote T Follicular Helper Cell Polarization through a Type I IFN and IL-6-Dependent Pathway. J Immunol. 2016;197:3884-3893 pubmed
    ..We determined that mice immunized with peptide or protein Ags emulsified in IFA or related water-in-oil adjuvants develop a highly polarized response in which the majority of ..
  38. Wang S, Li P, Lu S, Ling Z. Chemoprevention of Low-Molecular-Weight Citrus Pectin (LCP) in Gastrointestinal Cancer Cells. Int J Biol Sci. 2016;12:746-56 pubmed publisher
    ..We used AGS gastric cancer and SW-480 colorectal cancer cells to elucidate the effects of LCP on cell viability, cell cycle and ..
  39. Declercq P, Bubenheim M, Gelinotte S, Guernon K, Michot J, Royon V, et al. Usefulness of video-laryngoscopy with the Airway Scope for intubation performance and learning: an experimental manikin controlled study. Ann Intensive Care. 2016;6:83 pubmed publisher
    ..We compared the performance of the VDL Airway Scope (AWS) with the direct laryngoscopy by Macintosh (DLM) for ETI success, time and learning...
  40. Schmelzer L, Smitka M, Wolf C, Lucas N, Tüngler V, Hahn G, et al. Variable clinical phenotype in two siblings with Aicardi-Goutières syndrome type 6 and a novel mutation in the ADAR gene. Eur J Paediatr Neurol. 2018;22:186-189 pubmed publisher
    Aicardi-Goutières syndrome (AGS) is a hereditary inflammatory encephalopathy resulting in severe neurological damage in the majority of cases...
  41. Baez C, Brandão Varella R, Villani S, Delbue S. Human Polyomaviruses: The Battle of Large and Small Tumor Antigens. Virology (Auckl). 2017;8:1178122X17744785 pubmed publisher
    ..The 2 T-Ags are able to transform cells both in vitro and in vivo and seem to play a distinct role in the pathogenesis of some ..
  42. Das L, Kokate S, Dixit P, Rath S, Rout N, Singh S, et al. Membrane-bound ?-catenin degradation is enhanced by ETS2-mediated Siah1 induction in Helicobacter pylori-infected gastric cancer cells. Oncogenesis. 2017;6:e327 pubmed publisher
    ..pylori increased ETS2 transcription factor-mediated Siah1 protein expression in gastric cancer cells (GCCs) MKN45, AGS and Kato III...
  43. Huang S, Yang Z, Li D, Liu Z, Wang C, Miao X, et al. Jagged1 and DLL4 expressions in benign and malignant pancreatic lesions and their clinicopathological significance. Hepatobiliary Pancreat Dis Int. 2016;15:640-646 pubmed
    ..This study aimed to investigate the protein expressions of Jagged1 and DLL4 in PDAC tumor, benign pancreatic and normal pancreatic tissues, and analyze the associations of the two ..
  44. Abdel Salam G, Abdel Hamid M, Mohammad S, Abdel Ghafar S, Soliman D, El Bassyouni H, et al. Aicardi-Goutières syndrome: unusual neuro-radiological manifestations. Metab Brain Dis. 2017;32:679-683 pubmed publisher
    Aicardi-Goutières syndrome (AGS) is one of the expanding group of inherited congenital infection like syndromes. Here, we describe the detailed clinical and imaging findings of two sibs with AGS...
  45. Zhao K, Du J, Peng Y, Li P, Wang S, Wang Y, et al. LINE1 contributes to autoimmunity through both RIG-I- and MDA5-mediated RNA sensing pathways. J Autoimmun. 2018;90:105-115 pubmed publisher
    Improper host immune activation leads to the development of the autoimmune disease Aicardi-Goutières syndrome (AGS), which is attributed to defined genetic mutations in such proteins as TREX1 and ADAR1...
  46. Mahmoodi F, Akrami H. PlGF Knockdown Decreases Tumorigenicity and Stemness Properties of Spheroid Body Cells Derived from Gastric Cancer Cells. J Cell Biochem. 2017;118:851-859 pubmed publisher
    ..In this study, we isolated spheroid body cells which have stemness properties from MKN-45 and AGS without using growth factors. Validation of spheroid body cells was confirmed by various methods...
  47. Mao Q, Chen J, Dong L, Zhong L, Sun X. Krüppel-like factor 2 suppresses growth and invasion of gastric cancer cells in vitro and in vivo. J Biol Regul Homeost Agents. 2016;30:703-712 pubmed
    ..assay in human GC tissues, and lentivirus-mediated KLF2 overexpression was transfected into GC cells (AGS and HGC-27) for assessing cell proliferation and invasion, respectively indicated by MTT and Transwell assays...
  48. Zhang J, Wu J, Liu Y. Polycyclic aromatic hydrocarbons in urban green spaces of Beijing: concentration, spatial distribution and risk assessment. Environ Monit Assess. 2016;188:511 pubmed publisher
    ..as park green space (PGS), roadside green space (RDS), residential green space (RGS), and attached green space (AGS). Results showed that the highest concentrations of 15 PAHs was in soils of RDS, followed by RGS, PGS, and AGS...
  49. Rauch R, Hofbeck M, Zweier C, Koch A, Zink S, Trautmann U, et al. Comprehensive genotype-phenotype analysis in 230 patients with tetralogy of Fallot. J Med Genet. 2010;47:321-31 pubmed publisher
    ..2 deletion. We report a further patient with a recurrent polyalanine stretch elongation within TBX1 and for the first time link TBX1 cytoplasmatic protein aggregation to congenital heart defects. ..
  50. Sağir T, Huysal M, Durmus Z, Kurt B, Senel M, Isık S. Preparation and in vitro evaluation of 5-flourouracil loaded magnetite-zeolite nanocomposite (5-FU-MZNC) for cancer drug delivery applications. Biomed Pharmacother. 2016;77:182-90 pubmed publisher
    ..Cytotoxic effects of 5-FU loaded MZNC on human gastric carcinoma (AGS) cells were determined by real time cell analysis and colorimetric WST-1 cell viability assay...
  51. Held G, Luescher I, Neumann F, Papaioannou C, Schirrmann T, Sester M, et al. MHC/Peptide-Specific Interaction of the Humoral Immune System: A New Category of Antibodies. J Immunol. 2015;195:4210-7 pubmed publisher
    Abs bind to unprocessed Ags, whereas cytotoxic CD8(+) T cells recognize peptides derived from endogenously processed Ags presented in the context of class I MHC complexes...
  52. Navarro Ledesma S, Luque Suarez A. Comparison of acromiohumeral distance in symptomatic and asymptomatic patient shoulders and those of healthy controls. Clin Biomech (Bristol, Avon). 2018;53:101-106 pubmed publisher
    ..However, treatments focused on increasing AHD at 60° could be prescribed, as a significantly reduced AHD was found in symptomatic shoulders when compared with ..
  53. Rincon Restrepo M, Mayer A, Hauert S, Bonner D, Phelps E, Hubbell J, et al. Vaccine nanocarriers: Coupling intracellular pathways and cellular biodistribution to control CD4 vs CD8 T cell responses. Biomaterials. 2017;132:48-58 pubmed publisher
    Nanoparticle delivery systems are known to enhance the immune response to soluble antigens (Ags) and are thus a promising tool for the development of new vaccines...
  54. Fiaschetti G, Schroeder C, Castelletti D, Arcaro A, Westermann F, Baumgartner M, et al. NOTCH ligands JAG1 and JAG2 as critical pro-survival factors in childhood medulloblastoma. Acta Neuropathol Commun. 2014;2:39 pubmed publisher
    ..Finally, the positive correlation of MYC and JAG2 also with aggressive anaplastic tumors and highly metastatic MB stages suggested that high JAG2 expression may be useful as additional marker to identify aggressive MBs. ..
  55. Wu K, Treece A, Russo P, Wen J. An Atypical Presentation of Alagille Syndrome. Pediatr Dev Pathol. 2017;:1093526616686902 pubmed publisher
  56. Roy S, Ly D, Castro C, Li N, Hawk A, Altman J, et al. Molecular Analysis of Lipid-Reactive Vδ1 γδ T Cells Identified by CD1c Tetramers. J Immunol. 2016;196:1933-42 pubmed publisher
    CD1c is abundantly expressed on human dendritic cells (DC) and B cells, where it binds and displays lipid Ags to T cells...
  57. Jin H, Dai J, Meng L, Lu B. Curcuma wenyujin Y. H. Chen et C. Ling n-Butyl alcohol extract inhibits AGS cell Helicobacter pylori CagA+VacA+ promoted invasiveness by down-regulating caudal type homeobox transcription factor and claudin-2 expression. Chin J Integr Med. 2017;: pubmed publisher
    ..H. Chen et C. Ling n-Butyl alcohol extract (CWNAE) on repression of human gastric cancer (GC) AGS cell invasion induced by co-culturing with Helicobacter pylori (HP)...
  58. Tong M, Gonzalez Navarrete H, Kirchberg T, Gotama B, Yalcin E, Kay J, et al. Ethanol-Induced White Matter Atrophy Is Associated with Impaired Expression of Aspartyl-Asparaginyl-?-Hydroxylase (ASPH) and Notch Signaling in an Experimental Rat Model. J Drug Alcohol Res. 2017;6: pubmed publisher
    ..These findings link ethanol-induced WM atrophy to inhibition of ASPH expression and signaling through Notch networks, including HIF-1?...
  59. Yu C, Wang C, Chew Y, Wang P, Yin H, Kao M. Functional characterization of Helicobacter pylori 26695 sedoheptulose 7-phosphate isomerase encoded by hp0857 and its association with lipopolysaccharide biosynthesis and adhesion. Biochem Biophys Res Commun. 2016;477:794-800 pubmed publisher
    ..Furthermore, the adhesive capacity of the HP0857 knockout mutant to AGS cells was reduced significantly, and most of the infected cells didn't show a classic hummingbird phenotype...
  60. Chebil A, Leonard M, Six J, Nouvel C, Durand A. Nanoparticulate delivery systems for alkyl gallates: Influence of the elaboration process on particle characteristics, drug encapsulation and in-vitro release. Colloids Surf B Biointerfaces. 2018;162:351-361 pubmed publisher
    PLA nanoparticles loaded with n-alkyl gallates (AGs) were prepared either by nanoprecipitation (NP) or by O/W emulsion/solvent evaporation (E/SE)...
  61. Terada N, Shiraishi T, Zeng Y, Aw Yong K, Mooney S, Liu Z, et al. Correlation of Sprouty1 and Jagged1 with aggressive prostate cancer cells with different sensitivities to androgen deprivation. J Cell Biochem. 2014;115:1505-15 pubmed publisher
    ..of two genes that are known to be regulated by miR-21, an androgen-regulated microRNA, Sprouty1 (SPRY1) and Jagged1 (JAG1) were significantly lower in LNCaP-cl1 than in LNCaP-cl5...
  62. Wang Z, Jin G, Wu Q, Wang R, Li Y. Immature colon carcinoma transcript-1 promotes proliferation of gastric cancer cells. Acta Biochim Biophys Sin (Shanghai). 2017;49:979-988 pubmed publisher
    ..Then in order to study the role of ICT1 in gastric cancer, two shRNAs were used to silence ICT1 in MGC80-3 and AGS cells...
  63. Uyur Yalçın E, Maraş Genç H, Kara B. Clinical and neuroradiologic variability of Aicardi-Goutiéres syndrome: Two siblings with RNASEH2C mutation and a boy with TREX1 mutation. Turk J Pediatr. 2015;57:504-8 pubmed
    Aicardi-Goutières syndrome (AGS) is a rare, autosomal recessively inherited, immune-mediated neurodevelopmental disorder...
  64. Jing Y, Campanaro S, Kougias P, Treu L, Angelidaki I, Zhang S, et al. Anaerobic granular sludge for simultaneous biomethanation of synthetic wastewater and CO with focus on the identification of CO-converting microorganisms. Water Res. 2017;126:19-28 pubmed publisher
    ..In the present study, anaerobic granular sludge (AGS) was used for the simultaneous biomethanation of wastewater and CO...
  65. Maxfield N. Semantic and Phonological Encoding Times in Adults Who Stutter: Brain Electrophysiological Evidence. J Speech Lang Hear Res. 2017;60:2906-2923 pubmed publisher
    ..of stuttering propose that language production operates along a different time course in adults who stutter (AWS) versus typically fluent adults (TFA). However, behavioral evidence for such a difference has been mixed...
  66. Simonelli V, Leuzzi G, Basile G, D Errico M, Fortini P, Franchitto A, et al. Crosstalk between mismatch repair and base excision repair in human gastric cancer. Oncotarget. 2017;8:84827-84840 pubmed publisher
    ..insight into possible crosstalk of these two repair pathways in cancer, we analysed human gastric adenocarcinoma AGS cells over-expressing Pol? or Pol? active site mutants, alone or in combination with MLH1 silencing...
  67. Wang L, Wu R, Fu W, Lao Y, Zheng C, Tan H, et al. Synthesis and biological evaluation of Oblongifolin C derivatives as c-Met inhibitors. Bioorg Med Chem. 2016;24:4120-4128 pubmed publisher
    ..and tested for c-Met kinase inhibition and cytotoxicity against the HepG2, Miapaca-2, HCC827, Hela, A549, AGS, and HT-29 cell lines in vitro...
  68. Chen Z, Zhang N, Qi J, Chen R, Dijkstra J, Li X, et al. The Structure of the MHC Class I Molecule of Bony Fishes Provides Insights into the Conserved Nature of the Antigen-Presenting System. J Immunol. 2017;199:3668-3678 pubmed publisher
    ..This demonstration of the structure of a bony fish MHC class I molecule provides a foundation for understanding the evolution of primitive class I molecules, how they present peptide Ags, and how they might control T cell responses.
  69. Daliri A, Max L. Stuttering adults' lack of pre-speech auditory modulation normalizes when speaking with delayed auditory feedback. Cortex. 2018;99:55-68 pubmed publisher
    Auditory modulation during speech movement planning is limited in adults who stutter (AWS), but the functional relevance of the phenomenon itself remains unknown...
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