Gene Symbol: IWS1
Description: IWS1, SUPT6H interacting protein
Alias: protein IWS1 homolog, IWS1 homolog, IWS1-like protein, interacts with Spt6
Species: human
Products:     IWS1

Top Publications

  1. Diebold M, Koch M, Loeliger E, Cura V, Winston F, Cavarelli J, et al. The structure of an Iws1/Spt6 complex reveals an interaction domain conserved in TFIIS, Elongin A and Med26. EMBO J. 2010;29:3979-91 pubmed publisher
    Binding of elongation factor Spt6 to Iws1 provides an effective means for coupling eukaryotic mRNA synthesis, chromatin remodelling and mRNA export...
  2. Oqani R, Lin T, Lee J, Kang J, Shin H, Il Jin D. Iws1 and Spt6 Regulate Trimethylation of Histone H3 on Lysine 36 through Akt Signaling and are Essential for Mouse Embryonic Genome Activation. Sci Rep. 2019;9:3831 pubmed publisher
    The mRNA processing and export factor, Iws1, interacts with the histone H3/H4 chaperone, Spt6 (Supt6 in mouse gene ontology) and recruits the lysine methyltransferase, Setd2, to chromatin to regulate H3K36me3...
  3. Koch M, Diebold M, Cavarelli J, Romier C. Crystallization and preliminary crystallographic analysis of eukaryotic transcription and mRNA export factor Iws1 from Encephalitozoon cuniculi. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010;66:207-10 pubmed publisher
    ..The essential protein Iws1 is at the interface of these processes through its interaction with histone chaperone and elongation factor Spt6 as ..
  4. Park J, Lee C, Chang M, Kim K, Choi S, Lee H, et al. Molecular Characterization and Putative Pathogenic Pathways of Tuberous Sclerosis Complex-Associated Renal Cell Carcinoma. Transl Oncol. 2018;11:962-970 pubmed publisher
    ..In Case 2, genetic alterations of IWS1 and TSC2 were identified...
  5. Kadambari G, Vemireddy L, Srividhya A, Nagireddy R, Jena S, Gandikota M, et al. QTL-Seq-based genetic analysis identifies a major genomic region governing dwarfness in rice (Oryza sativa L.). Plant Cell Rep. 2018;37:677-687 pubmed publisher
    ..51 Kb. The sequencing of the QTL region and gene expression analysis predicted a gene that codes for IWS1 (C-terminus family protein)...
  6. Yoh S, Cho H, Pickle L, Evans R, Jones K. The Spt6 SH2 domain binds Ser2-P RNAPII to direct Iws1-dependent mRNA splicing and export. Genes Dev. 2007;21:160-74 pubmed
    ..We cloned the human Spt6-interacting protein, hIws1 (interacts with Spt6), and found that it associates with the nuclear RNA export factor, REF1/Aly...
  7. Liu Z, Zhou Z, Chen G, Bao S. A putative transcriptional elongation factor hIws1 is essential for mammalian cell proliferation. Biochem Biophys Res Commun. 2007;353:47-53 pubmed
    b>Iws1 has been implicated in transcriptional elongation by interaction with RNA polymerase II (RNAP II) and elongation factor Spt6 in budding yeast Saccharomyces cerevisiae, and association with transcription factor TFIIS in mammalian ..
  8. Yoh S, Lucas J, Jones K. The Iws1:Spt6:CTD complex controls cotranscriptional mRNA biosynthesis and HYPB/Setd2-mediated histone H3K36 methylation. Genes Dev. 2008;22:3422-34 pubmed publisher
    ..recently that Spt6, a transcription elongation factor and histone H3 chaperone, binds to the Ser2P CTD and recruits Iws1 and the REF1/Aly mRNA export adaptor to facilitate mRNA export...
  9. Gao K, Xu C, Jin X, Wumaier R, Ma J, Peng J, et al. HDGF-related protein-2 (HRP-2) acts as an oncogene to promote cell growth in hepatocellular carcinoma. Biochem Biophys Res Commun. 2015;458:849-55 pubmed publisher
    ..Furthermore, we demonstrate HRP-2 interacts and co-localizes with RNA processing regulator IWS1, and positively regulated the mRNA level of Cyclin D1...

More Information


  1. Ling Y, Smith A, Morgan G. A sequence motif conserved in diverse nuclear proteins identifies a protein interaction domain utilised for nuclear targeting by human TFIIS. Nucleic Acids Res. 2006;34:2219-29 pubmed
    ..However, in one of the newly identified proteins, hIWS1 (human Iws1), a region containing classic nuclear localization signals (NLS) rather than the LW motif was necessary and ..
  2. Sanidas I, Polytarchou C, Hatziapostolou M, Ezell S, Kottakis F, Hu L, et al. Phosphoproteomics screen reveals akt isoform-specific signals linking RNA processing to lung cancer. Mol Cell. 2014;53:577-90 pubmed publisher
    ..One of the top cellular functions differentially regulated by Akt isoforms is RNA processing. IWS1, an RNA processing regulator, is phosphorylated by Akt3 and Akt1 at Ser720/Thr721...
  3. Gérard A, Ségéral E, Naughtin M, Abdouni A, Charmeteau B, Cheynier R, et al. The integrase cofactor LEDGF/p75 associates with Iws1 and Spt6 for postintegration silencing of HIV-1 gene expression in latently infected cells. Cell Host Microbe. 2015;17:107-17 pubmed publisher
    ..LEDGF/p75 associated with two proteins involved in the control of gene expression and chromatin structure, Spt6 and Iws1, to form a stable complex...
  4. Tesina P, Cermakova K, Horejsi M, Prochazkova K, Fabry M, Sharma S, et al. Multiple cellular proteins interact with LEDGF/p75 through a conserved unstructured consensus motif. Nat Commun. 2015;6:7968 pubmed publisher
    ..In addition, based on IBM conservation, we identify and validate IWS1 as a novel LEDGF/p75 interaction partner...