Genomes and Genes
Gene Symbol: IWS1
Description: IWS1, SUPT6H interacting protein
Alias: protein IWS1 homolog, IWS1 homolog, IWS1-like protein, interacts with Spt6
- Ling Y, Smith A, Morgan G. A sequence motif conserved in diverse nuclear proteins identifies a protein interaction domain utilised for nuclear targeting by human TFIIS. Nucleic Acids Res. 2006;34:2219-29 pubmed..However, in one of the newly identified proteins, hIWS1 (human Iws1), a region containing classic nuclear localization signals (NLS) rather than the LW motif was necessary and ..
- Sanidas I, Polytarchou C, Hatziapostolou M, Ezell S, Kottakis F, Hu L, et al. Phosphoproteomics screen reveals akt isoform-specific signals linking RNA processing to lung cancer. Mol Cell. 2014;53:577-90 pubmed publisher..One of the top cellular functions differentially regulated by Akt isoforms is RNA processing. IWS1, an RNA processing regulator, is phosphorylated by Akt3 and Akt1 at Ser720/Thr721...
- GÃ©rard A, SÃ©gÃ©ral E, Naughtin M, Abdouni A, Charmeteau B, Cheynier R, et al. The integrase cofactor LEDGF/p75 associates with Iws1 and Spt6 for postintegration silencing of HIV-1 gene expression in latently infected cells. Cell Host Microbe. 2015;17:107-17 pubmed publisher..LEDGF/p75 associated with two proteins involved in the control of gene expression and chromatin structure, Spt6 and Iws1, to form a stable complex...
- Tesina P, Cermakova K, Horejsi M, Prochazkova K, Fabry M, Sharma S, et al. Multiple cellular proteins interact with LEDGF/p75 through a conserved unstructured consensus motif. Nat Commun. 2015;6:7968 pubmed publisher..In addition, based on IBM conservation, we identify and validate IWS1 as a novel LEDGF/p75 interaction partner...