Gene Symbol: ITPR3
Description: inositol 1,4,5-trisphosphate receptor type 3
Alias: IP3R, IP3R3, inositol 1,4,5-trisphosphate receptor type 3, IP3 receptor, inositol 1,4,5-triphosphate receptor, type 3, insP3R3, type 3 InsP3 receptor
Species: human
Products:     ITPR3

Top Publications

  1. Hattori M, Suzuki A, Higo T, Miyauchi H, Michikawa T, Nakamura T, et al. Distinct roles of inositol 1,4,5-trisphosphate receptor types 1 and 3 in Ca2+ signaling. J Biol Chem. 2004;279:11967-75 pubmed
    ..Therefore, differential expression of the IP(3)R subtype is critical for various forms of Ca(2+) signaling, and, particularly, IP(3)R1 and IP(3)R3 have opposite roles in generating Ca(2+) oscillations. ..
  2. Shibao K, Fiedler M, Nagata J, Minagawa N, Hirata K, Nakayama Y, et al. The type III inositol 1,4,5-trisphosphate receptor is associated with aggressiveness of colorectal carcinoma. Cell Calcium. 2010;48:315-23 pubmed publisher
    ..These findings suggest a previously unrecognized role for Ca(2+) signaling via this InsP3R isoform in colon cancer. ..
  3. Ehrlich L, Medina G, Khan M, Powell M, Mikoshiba K, Carter C. Activation of the inositol (1,4,5)-triphosphate calcium gate receptor is required for HIV-1 Gag release. J Virol. 2010;84:6438-51 pubmed publisher
    ..The inositol (1,4,5)-triphosphate receptor (IP3R) gates intracellular Ca(2+) stores...
  4. Ehrlich L, Medina G, Carter C. ESCRT machinery potentiates HIV-1 utilization of the PI(4,5)P(2)-PLC-IP3R-Ca(2+) signaling cascade. J Mol Biol. 2011;413:347-58 pubmed publisher
    ..We recently showed that budding requires activation of the inositol 1,4,5-triphosphate receptor (IP3R), a protein that "gates" Ca(2+) release from intracellular stores, triggers Ca(2+) cell influx and ..
  5. Szado T, Vanderheyden V, Parys J, De Smedt H, Rietdorf K, Kotelevets L, et al. Phosphorylation of inositol 1,4,5-trisphosphate receptors by protein kinase B/Akt inhibits Ca2+ release and apoptosis. Proc Natl Acad Sci U S A. 2008;105:2427-32 pubmed publisher
    ..We propose that PKB-mediated abolition of InsP(3)-induced Ca(2+) release may afford tumor cells a survival advantage. ..
  6. Koriauli S, Natsvlishvili N, Barbakadze T, Mikeladze D. Knockdown of interleukin-10 induces the redistribution of sigma1-receptor and increases the glutamate-dependent NADPH-oxidase activity in mouse brain neurons. Biol Res. 2015;48:55 pubmed publisher
    ..C3 botulinum toxin substrate 1), NR2B subunit of NMDA-receptor (NMDAR) and inositol-3-phosphate receptor (IP3R) is higher in the IL-10 KO mice brain than in the Wt mice brain...
  7. Murillo A, Vera Estrella R, Barkla B, Méndez E, Arias C. Identification of Host Cell Factors Associated with Astrovirus Replication in Caco-2 Cells. J Virol. 2015;89:10359-70 pubmed publisher
    ..DHCR7, CYP51A1) and fatty acid (FASN) synthesis, phosphatidylinositol (PI4KIIIβ) and inositol phosphate (ITPR3) metabolism, and RNA helicase activity (DDX23) significantly decreased the amounts of Yuc8 genomic and antigenomic ..
  8. Chantong B, Kratschmar D, Lister A, Odermatt A. Inhibition of metabotropic glutamate receptor 5 induces cellular stress through pertussis toxin-sensitive Gi-proteins in murine BV-2 microglia cells. J Neuroinflammation. 2014;11:190 pubmed publisher
    ..elevation of [Ca(2+)]i, following Ca(2+) release from the ER, mainly via inositol triphosphate-induced receptors (IP3R)...
  9. Song Q, Gou W, Zou Y. FAM3A Protects Against Glutamate-Induced Toxicity by Preserving Calcium Homeostasis in Differentiated PC12 Cells. Cell Physiol Biochem. 2017;44:2029-2041 pubmed publisher
    ..also inhibited the intracellular Ca2+ release mediated by mGluR1/5 and inositol 1,4,5-trisphosphate receptor (IP3R), but not the ryanodine receptor (RyR)...

More Information

Publications130 found, 100 shown here

  1. Guo Z, Zhang Y, Xie G, Liu C, Zhou R, Shi W. Down-regulation of Homer1 attenuates t-BHP-induced oxidative stress through regulating calcium homeostasis and ER stress in brain endothelial cells. Biochem Biophys Res Commun. 2016;477:970-976 pubmed publisher
    ..The results of Ca(2+) imaging showed that Homer1 was involved in inositol trisphosphate receptors (IP3R)- and ryanodine receptor (RyR)-mediated intracellular Ca(2+) release, and also mediated t-BHP-induced Ca(2+) ..
  2. Lin B, Tsai M, Lii C, Wang T. IP3 and calcium signaling involved in the reorganization of the actin cytoskeleton and cell rounding induced by cigarette smoke extract in human endothelial cells. Environ Toxicol. 2016;31:1293-1306 pubmed publisher
    ..CSE-induced intracellular calcium increase was suppressed by pretreatment with the inositol trisphosphate receptor (IP3R) inhibitor xestospongin C, the phospholipase C (PLC) inhibitor U-73122, and the protein kinase C (PKC) inhibitor ..
  3. Song Y, Huang C, Shi X, Pan Y, Liu X, Luo Z. Endoplasmic reticulum stress and dysregulation of calcium homeostasis mediate Cu-induced alteration in hepatic lipid metabolism of javelin goby Synechogobius hasta. Aquat Toxicol. 2016;175:20-9 pubmed publisher
    ..intracellular Ca(2+) elevation, which demonstrated the release of Ca(2+) from the ER was mediated by both RyR and IP3R. In experiment 4, a chemical chaperone, 4-phenyl butyric acid (4-PBA), was used to demonstrate whether Cu-induced ..
  4. Zhou T, Ma F, Shi X, Xu X, Du T, Guo X, et al. DMT efficiently inhibits hepatic gluconeogenesis by regulating the Gαq signaling pathway. J Mol Endocrinol. 2017;59:151-169 pubmed publisher
    ..DMT-inhibited gluconeogenesis by regulating the Gαq/phospholipase C (PLC)/inositol-1,4,5-triphosphate receptor (IP3R)-mediated calcium (Ca2+)/calmodulin (CaM)/phosphatidylinositol-4,5-bisphosphate 3-kinase (PI3K)/protein ..
  5. Kim J, Lee K, Park S, Kang S, Huang J, Lee J, et al. Omega-3 fatty acids induce Ca(2+) mobilization responses in human colon epithelial cell lines endogenously expressing FFA4. Acta Pharmacol Sin. 2015;36:813-20 pubmed publisher pretreatment with Ca(2+)ATPase inhibitor thapsigargin, but was not affected by Gi/o protein inhibitor PTX or IP3R inhibitor 2-APB...
  6. Bunbanjerdsuk S, Vorasan N, Saethang T, Pongrujikorn T, Pangpunyakulchai D, Mongkonsiri N, et al. Oncoproteomic and gene expression analyses identify prognostic biomarkers for second primary malignancy in patients with head and neck squamous cell carcinoma. Mod Pathol. 2019;: pubmed publisher
    ..p16-negative cases, we showed that a multivariate logistic regression model comprising the expression levels of ITPR3, KMT2D, EMILIN1, and the patient's age can accurately predict second primary malignancy occurrence with 88% ..
  7. Jing Y, An H, Zhang S, Wang N, Zhou S. Protein kinase C mediates juvenile hormone-dependent phosphorylation of Na+/K+-ATPase to induce ovarian follicular patency for yolk protein uptake. J Biol Chem. 2018;293:20112-20122 pubmed publisher
    ..receptor (GPCR), receptor tyrosine kinase (RTK), phospholipase C (PLC), inositol trisphosphate receptor (IP3R), and protein kinase C (PKC) to phosphorylate Na+/K+-ATPase α-subunit at amino acid residue ..
  8. Huo L, Zhang J, Qu Z, Chen H, Li Y, Gao W. Vasorelaxant effects of Shunaoxin pill are mediated by NO/cGMP pathway, HO/CO pathway and calcium channel blockade in isolated rat thoracic aorta. J Ethnopharmacol. 2015;173:352-60 pubmed publisher
    ..The NO/cGMP and HO/CO pathways, blockade of Ca(2+) channels are inhibition of IP3R mediated Ca(2+) mobilization from intracellular stores, are likely involved in this relaxation...
  9. Yuan Z, Cao A, Liu H, Guo H, Zang Y, Wang Y, et al. Calcium Uptake via Mitochondrial Uniporter Contributes to Palmitic Acid-Induced Apoptosis in Mouse Podocytes. J Cell Biochem. 2017;118:2809-2818 pubmed publisher
    ..prevented this upregulation whereas 2-aminoethoxydiphenyl borate (2-APB), an inositol 1,4,5-triphosphate receptor (IP3R) inhibitor; dantrolene, a ryanodine receptor (RyR) inhibitor; and 4,4'-diisothiocyanatostibene-2,2'-disulfonic acid ..
  10. Koli S, Prakash A, Choudhury S, Mandil R, Garg S. Calcium Channels, Rho-Kinase, Protein Kinase-C, and Phospholipase-C Pathways Mediate Mercury Chloride-Induced Myometrial Contractions in Rats. Biol Trace Elem Res. 2019;187:418-424 pubmed publisher
    ..PIP2: phospho-inositol bisphosphate; PLC: phospholipase-C; DAG: diacyl glycerol; IP3: inositol triphosphate; IP3R: inositol triphosphate receptor; PKC; protein kinase-C; MLCP: myosin light chain phosphatise; MYPT: myosin ..
  11. Petravicz J, Boyt K, McCarthy K. Astrocyte IP3R2-dependent Ca(2+) signaling is not a major modulator of neuronal pathways governing behavior. Front Behav Neurosci. 2014;8:384 pubmed publisher
    ..that most, if not all, receptor dependent Ca(2+) fluxes within astrocytes are due to release of Ca(2+) through IP3 receptor/channels in the endoplasmic reticulum...
  12. Hsieh S, Wu C, Hsu S, Yen J. Molecular mechanisms of gallic acid-induced growth inhibition, apoptosis, and necrosis in hypertrophic scar fibroblasts. Life Sci. 2017;179:130-138 pubmed publisher
    ..Various blockers, including intracellular calcium chelator; BAPTA-AM, IP3R blocker; 2-APB, calpain inhibitor, ALLM and ALLN were used to address the signaling cascade in GA-induced HSF ..
  13. Andersson A, Bluwstein A, Kumar N, Teloni F, Traenkle J, Baudis M, et al. PKC? and HMGB1 antagonistically control hydrogen peroxide-induced poly-ADP-ribose formation. Nucleic Acids Res. 2016;44:7630-45 pubmed publisher
    ..analysis of key stress signaling components, we observed that PAR formation induced by H2O2 was mediated by the PLC/IP3R/Ca(2+)/PKC? signaling axis...
  14. Andruska N, Zheng X, Yang X, Mao C, Cherian M, Mahapatra L, et al. Estrogen receptor α inhibitor activates the unfolded protein response, blocks protein synthesis, and induces tumor regression. Proc Natl Acad Sci U S A. 2015;112:4737-42 pubmed publisher
    ..BHPI rapidly hyperactivates plasma membrane PLCγ, generating inositol 1,4,5-triphosphate (IP3), which opens EnR IP3R calcium channels, rapidly depleting EnR Ca(2+) stores. This leads to activation of all three arms of the UPR...
  15. Ambudkar I. Calcium signaling defects underlying salivary gland dysfunction. Biochim Biophys Acta Mol Cell Res. 2018;1865:1771-1777 pubmed publisher
    ..Under physiological conditions depletion of ER-Ca2+ stores is caused by activation of IP3R by IP3 and this provides the stimulus for SOCE...
  16. Li Y, Lin X, Zhao X, Xie J, JunNan W, Sun T, et al. Ozone (O3) elicits neurotoxicity in spinal cord neurons (SCNs) by inducing ER Ca(2+) release and activating the CaMKII/MAPK signaling pathway. Toxicol Appl Pharmacol. 2014;280:493-501 pubmed publisher
    ..Intracellular Ca(2+) chelator, ER stabilizer (inositol 1,4,5-trisphosphate receptor (IP3R) antagonist and ryanodine receptor (RyR) antagonist) and calcium/calmodulin-dependent protein kinase II (CaMKII) ..
  17. Srivastava R, Li C, Wang Y, Weng Z, Elmets C, Harrod K, et al. Activating transcription factor 4 underlies the pathogenesis of arsenic trioxide-mediated impairment of macrophage innate immune functions. Toxicol Appl Pharmacol. 2016;308:46-58 pubmed publisher
    ..Ca(++) homeostasis in ER/mitochondria by treatments with the inhibitors of inositol 1,4,5-trisphosphate receptor (IP3R) and voltage-dependent anion channel (VDAC) attenuate innate immune functions of macrophages...
  18. Chung K, Jeong E, Park H, An H, Yu S. Mediation of Autophagic Cell Death by Type 3 Ryanodine Receptor (RyR3) in Adult Hippocampal Neural Stem Cells. Front Cell Neurosci. 2016;10:116 pubmed publisher
    ..Despite comparable expression levels of RyR and IP3R transcripts in HCN cells at normal state, the expression levels of RyRs-especially RyR3-were markedly upregulated ..
  19. Lin B, Willemsen G, Fedko I, Jansen R, Penninx B, De Geus E, et al. Heritability and GWAS Studies for Monocyte-Lymphocyte Ratio. Twin Res Hum Genet. 2017;20:97-107 pubmed publisher
    ..For monocyte count, additional genetic variants were identified on ITPR3, LPAP1, and IRF8. For lymphocyte count, GWAS provided no significant findings...
  20. Yin K, Yang Z, Gong Y, Wang D, Lin H. The antagonistic effect of Se on the Pb-weakening formation of neutrophil extracellular traps in chicken neutrophils. Ecotoxicol Environ Saf. 2019;173:225-234 pubmed publisher
    ..the release of Ca2+ in the endoplasmic reticulum mediated by the inositol 1,4,5-trisphosphate receptor (IP3R). These are two ways by which Pb decreases the formation of NETs...
  21. Plattner H. Molecular aspects of calcium signalling at the crossroads of unikont and bikont eukaryote evolution--the ciliated protozoan Paramecium in focus. Cell Calcium. 2015;57:174-85 pubmed publisher
    ..All IP3R/RyR-type CRCs possess six carboxyterminal transmembrane domains (TMD), with a pore domain between TMD 5 and 6, ..
  22. Yan X, Liu J, Zhang Z, Li W, Sun S, Zhao J, et al. Low-level laser irradiation modulates brain-derived neurotrophic factor mRNA transcription through calcium-dependent activation of the ERK/CREB pathway. Lasers Med Sci. 2017;32:169-180 pubmed publisher
    ..kinase (ERK) phosphorylation, mediated by Ca2+ release via inositol triphosphate receptor (IP3R)-sensitive calcium (Ca2+) stores...
  23. Kovacevic I, Orozco J, Cram E. Filamin and phospholipase C-ε are required for calcium signaling in the Caenorhabditis elegans spermatheca. PLoS Genet. 2013;9:e1003510 pubmed publisher
    ..Gain-of-function mutations in ITR-1/IP3R, an IP3-dependent calcium channel, and loss-of-function mutations in LFE-2, a negative regulator of IP3 signaling, ..
  24. Yuan Q, Yang J, Santulli G, Reiken S, Wronska A, Kim M, et al. Maintenance of normal blood pressure is dependent on IP3R1-mediated regulation of eNOS. Proc Natl Acad Sci U S A. 2016;113:8532-7 pubmed publisher
    ..that intracellular Ca(2+) release from the endoplasmic reticulum (ER) via inositol 1,4,5-trisphosphate receptor (IP3R) is required for Ca(2+)-dependent eNOS activation...
  25. Gu Y, Qi B, Zhou Y, Jiang X, Zhang X, Li X, et al. Porcine Circovirus Type 2 Activates CaMMK? to Initiate Autophagy in PK-15 Cells by Increasing Cytosolic Calcium. Viruses. 2016;8: pubmed publisher
    ..protein kinase kinase-beta (CaMKK?) by increasing cytosolic Ca(2+) via inositol 1,4,5-trisphosphate receptor (IP3R)...
  26. Domingues M, De Assis D, Piovesan A, Belo C, da Costa J. Peptide YY (3-36) modulates intracellular calcium through activation of the phosphatidylinositol pathway in hippocampal neurons. Neuropeptides. 2018;67:1-8 pubmed publisher
    ..prevent the PYY (3-36)-increase of [Ca2+]i and inositol 1,4,5-triphosphate receptor (IP3R) inhibition also decreased the PYY (3-36)-increase of [Ca2+]i...
  27. Kim H, Woo J, Lee J, Joe E, Jou I. 22(R)-hydroxycholesterol induces HuR-dependent MAP kinase phosphatase-1 expression via mGluR5-mediated Ca(2+)/PKC? signaling. Biochim Biophys Acta. 2016;1859:1056-70 pubmed publisher
    ..increases in intracellular Ca(2+) levels mediated by the phospholipase C/inositol 1,4,5-triphosphate receptor (PLC/IP3R) pathway and translocates from cytoplasm to nucleus...
  28. Schmunk G, Boubion B, Smith I, Parker I, Gargus J. Shared functional defect in IP₃R-mediated calcium signaling in diverse monogenic autism syndromes. Transl Psychiatry. 2015;5:e643 pubmed publisher
    ..IP3 at the levels of both global and local elementary Ca(2+) events, suggesting fundamental defects in IP3R channel activity in ASD...
  29. Konieczny V, Stefanakis J, Sitsanidis E, Ioannidou N, Papadopoulos N, Fylaktakidou K, et al. Synthesis of inositol phosphate-based competitive antagonists of inositol 1,4,5-trisphosphate receptors. Org Biomol Chem. 2016;14:2504-14 pubmed publisher
    ..We combined analyses of Ca(2+) release with equilibrium competition binding to IP3R to show that (1,3,4,6)IP4 is a full agonist of IP3R1 with lower affinity than (1,4,5)IP3...
  30. Alvarez A, Lagos Cabré R, Kong M, Cárdenas A, Burgos Bravo F, Schneider P, et al. Integrin-mediated transactivation of P2X7R via hemichannel-dependent ATP release stimulates astrocyte migration. Biochim Biophys Acta. 2016;1863:2175-88 pubmed publisher
    ..of phosphatidylinositol-3-kinase (PI3K), phospholipase-C gamma (PLC?) and inositol trisphosphate (IP3) receptors (IP3R)...
  31. Ehrlich L, Medina G, Carter C. Sprouty2 regulates PI(4,5)P2/Ca2+ signaling and HIV-1 Gag release. J Mol Biol. 2011;410:716-25 pubmed publisher
    We reported recently that activation of the inositol 1,4,5-triphosphate receptor (IP3R) is required for efficient HIV-1 Gag trafficking and viral particle release...
  32. Fredericks G, Hoffmann P. Selenoprotein K and protein palmitoylation. Antioxid Redox Signal. 2015;23:854-62 pubmed publisher
    ..SelK is required for palmitoylation of the Ca(2+) channel protein, inositol-1,4,5-triphosphate receptor (IP3R) in the ER membrane. Without this post-translational modification, expression and function of the IP3R is impaired...
  33. Borysova L, Burdyga T. Evidence that NO/cGMP/PKG signalling cascade mediates endothelium dependent inhibition of IP₃R mediated Ca²⁺ oscillations in myocytes and pericytes of ureteric microvascular network in situ. Cell Calcium. 2015;58:535-40 pubmed publisher
    ..The inhibitory effect of NO/cGMP/PKG cascade is associated with suppressed Ca(2+) release from the SR of myocytes and pericytes selectively via the inositol triphosphate receptor (IP3R) channels.
  34. Song Y, Luo Z, Zhang L, Hogstrand C, Pan Y. Endoplasmic reticulum stress and disturbed calcium homeostasis are involved in copper-induced alteration in hepatic lipid metabolism in yellow catfish Pelteobagrus fulvidraco. Chemosphere. 2016;144:2443-53 pubmed publisher
    ..fulvidraco in a time-dependent manner. In experiment 2, specific inhibitors 2-APB (IP3 receptor inhibitor) and dantrolene (RyR receptor inhibitor) were used to explore whether Ca(2+) release from ER was ..
  35. Park K, Kim S, Das A, Yang S, Jung K, Kim M, et al. TLR3-/4-Priming Differentially Promotes Ca(2+) Signaling and Cytokine Expression and Ca(2+)-Dependently Augments Cytokine Release in hMSCs. Sci Rep. 2016;6:23103 pubmed publisher
    ..Poly(I:C) exposure rather than LPS incubation not only elevated inositol 1,4,5-triphosphate receptor (IP3R) expression and IP3R-mediated Ca(2+) release, but also promoted Orai and STIM expression as well as store-operated ..
  36. Montaño L, Flores Soto E, Reyes García J, Díaz Hernández V, Carbajal García A, Campuzano González E, et al. Testosterone induces hyporesponsiveness by interfering with IP3 receptors in guinea pig airway smooth muscle. Mol Cell Endocrinol. 2018;473:17-30 pubmed publisher
    ..muscle, mRNA for each IP3 receptor (ITPR) isoform was found and, by immunofluorescence, ITPR1 and ITPR3 seems to be the main isoforms observed while ITPR2 was less prominent...
  37. Signore S, Sorrentino A, Ferreira Martins J, Kannappan R, Shafaie M, Del Ben F, et al. Inositol 1, 4, 5-trisphosphate receptors and human left ventricular myocytes. Circulation. 2013;128:1286-97 pubmed publisher
    ..b>IP3R function was determined in human left ventricular myocytes, and this analysis was integrated with assays in mouse ..
  38. Kazdoba T, Hagerman R, Zolkowska D, Rogawski M, Crawley J. Evaluation of the neuroactive steroid ganaxolone on social and repetitive behaviors in the BTBR mouse model of autism. Psychopharmacology (Berl). 2016;233:309-23 pubmed publisher
    ..BTBR T (+) Itpr3 (tf) /J (BTBR), an inbred mouse strain, displays social deficits and repetitive self-grooming, offering face ..
  39. Geng Y, Xing L, Sun M, Su F. Immunomodulatory effects of sulfated polysaccharides of pine pollen on mouse macrophages. Int J Biol Macromol. 2016;91:846-55 pubmed publisher
    ..The results showed that SPPM60-D mainly bound to TLR4 on macrophages. This activated the TLR4-PI3K-PLC-IP3R signaling pathway, leading to the opening of calcium release-activated calcium channels (CRAC), increasing [Ca(2+)]..
  40. Song X, Zhang Y, Wang H, Wen H, Zhao C, Lan Y, et al. Stereoselectivity of tradinterol's inhibition on proliferation of airway smooth muscle cells induced by acetylcholine through suppressing Ca(2+) signalling. J Physiol Pharmacol. 2016;67:363-75 pubmed
    ..2-APB, an (inositol 1,4,5-trisphosphate receptor) IP3R blocker, and NiCl2, a store-operated channel (SOC) inhibitor, were used to investigate the mechanism of SPFF ..
  41. Wang L, Almeida L, Nettleton M, Khaibullina A, Albani S, Kamimura S, et al. Altered nocifensive behavior in animal models of autism spectrum disorder: The role of the nicotinic cholinergic system. Neuropharmacology. 2016;111:323-334 pubmed publisher
    ..Here we examined nocifensive behavior in ASD mouse models, the BTBR T+Itpr3tf/J (BTBR) and the fragile-X mental retardation-1 knockout (Fmr1-KO) mice...
  42. Borodkina A, Shatrova A, Deryabin P, Griukova A, Abushik P, Antonov S, et al. Calcium alterations signal either to senescence or to autophagy induction in stem cells upon oxidative stress. Aging (Albany NY). 2016;8:3400-3418 pubmed publisher
    ..resulted in a rapid calcium release from intracellular stores mediated by the activation of PLC/IP3/IP3R pathway...
  43. Leno Colorado J, Hudson N, Reverter A, Perez Enciso M. A Pathway-Centered Analysis of Pig Domestication and Breeding in Eurasia. G3 (Bethesda). 2017;7:2171-2184 pubmed publisher the transduction of a large number of signals, like phospholipase PCLB1, which is expressed in the brain, or ITPR3, which has an important role in taste transduction...
  44. Nakabayashi K, Tajima A, Yamamoto K, Takahashi A, Hata K, Takashima Y, et al. Identification of independent risk loci for Graves' disease within the MHC in the Japanese population. J Hum Genet. 2011;56:772-8 pubmed publisher
    ..Although causal variants remain to be identified, our results demonstrate the existence of multiple GD susceptibility loci within the MHC region. ..
  45. Guo B, Zhang W, Tume R, Hudson N, Huang F, Yin Y, et al. Disorder of endoplasmic reticulum calcium channel components is associated with the increased apoptotic potential in pale, soft, exudative pork. Meat Sci. 2016;115:34-40 pubmed publisher
    ..We found that SERCA1 was decreased, while IP3R was decreased in PSE meat (P<0.05), indicative of the overloaded sarcoplasmic calcium status...
  46. Schulman J, Wright F, Han X, Zluhan E, Szczesniak L, Wojcikiewicz R. The Stability and Expression Level of Bok Are Governed by Binding to Inositol 1,4,5-Trisphosphate Receptors. J Biol Chem. 2016;291:11820-8 pubmed publisher
    ..receptors (IP3Rs), suggesting that it may contribute to the structural integrity or stability of IP3R tetramers...
  47. Hudecova S, Markova J, Simko V, Csaderova L, Stracina T, Sirova M, et al. Sulforaphane-induced apoptosis involves the type 1 IP3 receptor. Oncotarget. 2016;7:61403-61418 pubmed publisher
    ..inhibited by silencing of IP3R1 gene but only partially blocked by silencing of NRF2; silencing of IP3R2 and IP3R3 had no effect on these cells...
  48. Tadevosyan A, Xiao J, Surinkaew S, Naud P, Merlen C, Harada M, et al. Intracellular Angiotensin-II Interacts With Nuclear Angiotensin Receptors in Cardiac Fibroblasts and Regulates RNA Synthesis, Cell Proliferation, and Collagen Secretion. J Am Heart Assoc. 2017;6: pubmed publisher
    ..of a membrane-permeable caged Ang-II analog led to IP3R-dependent nucleoplasmic Ca2+-liberation, with IP3R3 being the predominant nuclear isoform...
  49. Torrealba N, Navarro Marquez M, Garrido V, Pedrozo Z, Romero D, Eura Y, et al. Herpud1 negatively regulates pathological cardiac hypertrophy by inducing IP3 receptor degradation. Sci Rep. 2017;7:13402 pubmed publisher
    ..of the synthesis and the degradation of the Ca2+ channel inositol 1,4,5-trisphosphate receptor (IP3R) affects progression to cardiac hypertrophy...
  50. Semenov D, Belyakov A, Glushchenko T, Samoilov M, Salinska E, Lazarewicz J. Hypobaric Preconditioning Modifies Group I mGluRs Signaling in Brain Cortex. Neurochem Res. 2015;40:2200-10 pubmed publisher
    ..of Ca(2+) signaling may represent pro-survival upregulation of Ca(2+)-dependent genomic processes, while decrease in mGluR1 and IP3R IR may be attributed to a feedback mechanism preventing excessive intracellular Ca(2+) release.
  51. Hedberg M, Goh G, Chiosea S, Bauman J, Freilino M, Zeng Y, et al. Genetic landscape of metastatic and recurrent head and neck squamous cell carcinoma. J Clin Invest. 2016;126:169-80 pubmed publisher
    ..tumor, but not in the respective primary tumors, include C17orf104, inositol 1,4,5-trisphosphate receptor, type 3 (ITPR3), and discoidin domain receptor tyrosine kinase 2 (DDR2)...
  52. Wang Y, Tu L, Li Y, Chen D, Liu Z, Hu X, et al. Notoginsenoside R1 Alleviates Oxygen-Glucose Deprivation/Reoxygenation Injury by Suppressing Endoplasmic Reticulum Calcium Release via PLC. Sci Rep. 2017;7:16226 pubmed publisher
    ..Recent evidence indicates that the Phospholipase C (PLC)/inositol 1,4,5-trisphosphate receptor (IP3R) is important for the regulation of Ca2+ release in the ER...
  53. Tojyo Y, Morita T, Nezu A, Tanimura A. The clustering of inositol 1,4,5-trisphosphate (IP(3)) receptors is triggered by IP(3) binding and facilitated by depletion of the Ca(2+) store. J Pharmacol Sci. 2008;107:138-50 pubmed
    ..Although depletion of the Ca(2+) store by itself does not cause the clustering, it may increase the sensitivity of IP(3)R to cluster formation, leading to facilitation of IP(3)-triggered clustering. ..
  54. Ando H, Hirose M, Gainche L, Kawaai K, Bonneau B, Ijuin T, et al. IRBIT Interacts with the Catalytic Core of Phosphatidylinositol Phosphate Kinase Type Iα and IIα through Conserved Catalytic Aspartate Residues. PLoS ONE. 2015;10:e0141569 pubmed publisher
    ..IRBIT (IP3R-binding protein released with inositol 1,4,5-trisphosphate) is a multifunctional protein that regulates diverse ..
  55. Wei W, Huang W, Yue J. Requirement of IP3 receptor 3 (IP3R3) in nitric oxide induced cardiomyocyte differentiation of mouse embryonic stem cells. Exp Cell Res. 2016;346:9-16 pubmed publisher
    ..Interestingly, only knockdown of type 3 IP3R (IP3R3) or triple-knockdown of three types of IP3Rs significantly inhibited the NO-induced Ca(2+) increases...
  56. Takada S, Ikebara J, de Sousa E, Cardoso D, Resende R, Ulrich H, et al. Determining the Roles of Inositol Trisphosphate Receptors in Neurodegeneration: Interdisciplinary Perspectives on a Complex Topic. Mol Neurobiol. 2017;54:6870-6884 pubmed publisher
    ..Therefore, regulation of IP3R gene products in specific cellular vicinities seems to be crucial in a wide range of cellular processes from ..
  57. Liu X, Song S, Wang Q, Yuan T, He J. A mutation in ?-amyloid precursor protein renders SH?SY5Y cells vulnerable to isoflurane toxicity: The role of inositol 1,4,5?trisphosphate receptors. Mol Med Rep. 2016;14:5435-5442 pubmed publisher
    ..cells vulnerable to isoflurane?induced cytotoxicity via activation of inositol 1,4,5?trisphosphate receptors (IP3R)...
  58. Reddish F, Miller C, Gorkhali R, Yang J. Monitoring ER/SR Calcium Release with the Targeted Ca2+ Sensor CatchER. J Vis Exp. 2017;: pubmed publisher
    ..from these organelles is mediated by the ryanodine receptor (RyR) and the inositol 1,4,5-triphosphate receptor (IP3R) with refilling occurring through the sarco/endoplasmic reticulum calcium ATPase (SERCA) pump...
  59. Hayashi T, Su T. Regulating ankyrin dynamics: Roles of sigma-1 receptors. Proc Natl Acad Sci U S A. 2001;98:491-6 pubmed
  60. Zhang Y, Zhou H, Wu W, Shi C, Hu S, Yin T, et al. Liraglutide protects cardiac microvascular endothelial cells against hypoxia/reoxygenation injury through the suppression of the SR-Ca(2+)-XO-ROS axis via activation of the GLP-1R/PI3K/Akt/survivin pathways. Free Radic Biol Med. 2016;95:278-92 pubmed publisher
    ..The results indicate that H/R increased IP3R expression but reduced SERCA2a expression, which rapidly raised intracellular Ca(2+) levels, subsequently leading ..
  61. Lopez J, Kolster J, Uryash A, Esteve E, Altamirano F, Adams J. Dysregulation of Intracellular Ca2+ in Dystrophic Cortical and Hippocampal Neurons. Mol Neurobiol. 2018;55:603-618 pubmed publisher
    ..Blockade of ryanodine receptors (RyR) or inositol triphosphate receptors (IP3R) reduced [Ca2+]i in mdx...
  62. Tang L, Wang J, Xu T, Zhao Z, Zheng J, Ge R, et al. Mitochondrial toxicity of perfluorooctane sulfonate in mouse embryonic stem cell-derived cardiomyocytes. Toxicology. 2017;382:108-116 pubmed publisher
    ..Furthermore, PFOS reduced the interaction of IP3R-Grp75-VDAC and accumulated intracellular fatty acids by activating Rictor, thereby attenuating PGC-1? and Mfn2 ..
  63. Li S, Wang Y, Zhao H, He Y, Li J, Jiang G, et al. NF-?B-mediated inflammation correlates with calcium overload under arsenic trioxide-induced myocardial damage in Gallus gallus. Chemosphere. 2017;185:618-627 pubmed publisher
    ..Moreover, As2O3 exposure significantly increased (P < 0.05) the mRNA levels of ITPR3, PMCA, TRPC1, TRPC3, STIM1, ORAI1 and pro-inflammatory genes, while the mRNA levels of ITPR1, ITPR2, RyR1, RyR3, ..
  64. Barr J, Deliu E, Brailoiu G, Zhao P, Yan G, Abood M, et al. Mechanisms of activation of nucleus accumbens neurons by cocaine via sigma-1 receptor-inositol 1,4,5-trisphosphate-transient receptor potential canonical channel pathways. Cell Calcium. 2015;58:196-207 pubmed publisher
    ..we identify a novel mechanism by which cocaine promotes activation of D1-expressing nAcc neurons: enhancement of IP3R-mediated responses via σ1R activation at the endoplasmic reticulum, resulting in augmented Ca(2+) release and ..
  65. Wang L, Almeida L, Spornick N, Kenyon N, Kamimura S, Khaibullina A, et al. Modulation of social deficits and repetitive behaviors in a mouse model of autism: the role of the nicotinic cholinergic system. Psychopharmacology (Berl). 2015;232:4303-16 pubmed publisher
    ..behavior abnormalities and exploratory physical activity in a well-studied model of autism, the BTBR T(+) Itpr3 (tf) /J (BTBR) mouse...
  66. Li H, Xie Y, Zhang N, Yu Y, Zhang Q, Ding S. Disruption of IP₃R2-mediated Ca²⁺ signaling pathway in astrocytes ameliorates neuronal death and brain damage while reducing behavioral deficits after focal ischemic stroke. Cell Calcium. 2015;58:565-76 pubmed publisher
    Inositol trisphosphate receptor (IP3R)-mediated intracellular Ca(2+) increase is the major Ca(2+) signaling pathway in astrocytes in the central nervous system (CNS)...
  67. Kang S, Hong J, Lee J, Moon H, Jeon B, Choi J, et al. Trifluoperazine, a Well-Known Antipsychotic, Inhibits Glioblastoma Invasion by Binding to Calmodulin and Disinhibiting Calcium Release Channel IP3R. Mol Cancer Ther. 2017;16:217-227 pubmed publisher
    ..On the basis of these findings, we propose TFP as a potential therapeutic drug for glioblastoma by aberrantly and irreversibly increasing Ca2+ in glioblastoma cells. Mol Cancer Ther; 16(1); 217-27. ©2016 AACR. ..
  68. Joseph S, Lin C, Pierson S, Thomas A, Maranto A. Heteroligomers of type-I and type-III inositol trisphosphate receptors in WB rat liver epithelial cells. J Biol Chem. 1995;270:23310-6 pubmed
    ..that a 222-kDa polypeptide co-immunoprecipitates together with the type-I myoinositol 1,4,5-trisphosphate receptor (IP3R) in WB rat liver epithelial cell extracts, when the immunoprecipitation is carried out with a type-I isoform ..
  69. Mound A, Rodat Despoix L, Bougarn S, Ouadid Ahidouch H, Matifat F. Molecular interaction and functional coupling between type 3 inositol 1,4,5-trisphosphate receptor and BKCa channel stimulate breast cancer cell proliferation. Eur J Cancer. 2013;49:3738-51 pubmed publisher
    ..Studies from our laboratory have shown that type 3 IP3 receptor (IP3R3) and voltage- and Ca(2+)-dependent K(+) channels BKCa channels are involved in human breast cancer cell ..
  70. Missiaen L, DeSmedt H, Bultynck G, Vanlingen S, Desmet P, Callewaert G, et al. Calmodulin increases the sensitivity of type 3 inositol-1,4, 5-trisphosphate receptors to Ca(2+) inhibition in human bronchial mucosal cells. Mol Pharmacol. 2000;57:564-7 pubmed
    ..It is concluded that: 1) IP(3)R3 can be inhibited by calmodulin, 2) IP(3)R3 is inhibited by high Ca(2+) concentrations, and 3) calmodulin shifts the inhibitory part of the Ca(2+)-response curve toward lower Ca(2+) concentrations. ..
  71. Wen H, Kang S, Song Y, Song Y, Yang H, Kim M, et al. Characterization of the binding sites for the interactions between FKBP12 and intracellular calcium release channels. Arch Biochem Biophys. 2012;517:37-42 pubmed publisher
    ..We believe our results shed lights on the binding mechanism of calcium channel-FKBP12 interaction. ..
  72. Marchi S, Marinello M, Bononi A, Bonora M, Giorgi C, Rimessi A, et al. Selective modulation of subtype III IP?R by Akt regulates ER Ca²? release and apoptosis. Cell Death Dis. 2012;3:e304 pubmed publisher
    ..These results demonstrate a specific activity of Akt on IP?R III, leading to diminished Ca²? transfer to mitochondria and protection from apoptosis, suggesting an additional level of cell death regulation mediated by Akt. ..
  73. Megha -, Hasan G. IP3R-mediated Ca2+ release regulates protein metabolism in Drosophila neuroendocrine cells: implications for development under nutrient stress. Development. 2017;144:1484-1489 pubmed publisher
    ..Thus cell-specific regulation of protein synthesis by IP3R in NE cells influences protein metabolism. We propose that this regulation helps developing animals survive in poor nutritional conditions. ..
  74. Yang Y, Chang T, Chen T, Lin W, Chang S, Lee Y. ITPR3 gene haplotype is associated with cervical squamous cell carcinoma risk in Taiwanese women. Oncotarget. 2017;8:10085-10090 pubmed publisher
    ..Inositol 1,4,5-triphosphate receptor type 3 (ITPR3) is essential for both immune activation and cancer pathogenesis...
  75. Fujimoto T, Machida T, Tsunoda T, Doi K, Ota T, Kuroki M, et al. Determination of the critical region of KRAS-induced actin-interacting protein for the interaction with inositol 1,4,5-trisphosphate receptor. Biochem Biophys Res Commun. 2011;408:282-6 pubmed publisher
    ..All these results provide insight into the understandings for the molecular mechanisms underlying the regulation of IP(3)R, and would reveal a potent strategy for the drug development targeting on IP(3)R. ..
  76. Shambharkar P, Bittinger M, Latario B, Xiong Z, Bandyopadhyay S, Davis V, et al. TMEM203 Is a Novel Regulator of Intracellular Calcium Homeostasis and Is Required for Spermatogenesis. PLoS ONE. 2015;10:e0127480 pubmed publisher
    ..Thus Tmem203 is an evolutionarily conserved regulator of cellular calcium homeostasis, is required for spermatogenesis and provides a causal link between intracellular calcium regulation and spermiogenesis. ..
  77. Bandyopadhyay B, Swaim W, Liu X, Redman R, Patterson R, Ambudkar I. Apical localization of a functional TRPC3/TRPC6-Ca2+-signaling complex in polarized epithelial cells. Role in apical Ca2+ influx. J Biol Chem. 2005;280:12908-16 pubmed
    ..These data demonstrate functional localization of TRPC3/TRPC6 channels in the apical region of polarized epithelial cells. In salivary gland ducts this could contribute to the regulation of salivary [Ca2+] and secretion. ..
  78. Stobart J, Ferrari K, Barrett M, Stobart M, Looser Z, Saab A, et al. Long-term In Vivo Calcium Imaging of Astrocytes Reveals Distinct Cellular Compartment Responses to Sensory Stimulation. Cereb Cortex. 2018;28:184-198 pubmed publisher
    ..Although mice genetically lacking astrocytic IP3R-dependent calcium signaling (Ip3r2-/-) had fewer signal peaks, the response to sensory stimulation was sustained, ..
  79. Maranto A. Primary structure, ligand binding, and localization of the human type 3 inositol 1,4,5-trisphosphate receptor expressed in intestinal epithelium. J Biol Chem. 1994;269:1222-30 pubmed
    ..The majority of clones encoded the type 3 InsP3R, the product of the ITPR3 gene on chromosome 6, for which only a 147-amino-acid fragment was known previously (Ozcelik, T., Sudhof, T. C...
  80. Fushan A, Simons C, Slack J, Drayna D. Association between common variation in genes encoding sweet taste signaling components and human sucrose perception. Chem Senses. 2010;35:579-92 pubmed publisher
    ..Collectively, GNAT3 polymorphisms explain 13% of the variation in sucrose perception. Our findings underscore the importance of common genetic variants influencing human taste perception. ..
  81. Mukherjee S, Duan F, Kolb M, Janssen L. Platelet derived growth factor-evoked Ca2+ wave and matrix gene expression through phospholipase C in human pulmonary fibroblast. Int J Biochem Cell Biol. 2013;45:1516-24 pubmed publisher effect on PDGF-evoked Ca(2+) wave, whereas the phospholipase C inhibitor U73122 and Xestospongin C, a potent IP3 receptor blocker, reduced the rapid PDGF-response to a relatively slowly-developing rise in [Ca(2+)]i...
  82. Yang J, McBride S, Mak D, Vardi N, Palczewski K, Haeseleer F, et al. Identification of a family of calcium sensors as protein ligands of inositol trisphosphate receptor Ca(2+) release channels. Proc Natl Acad Sci U S A. 2002;99:7711-6 pubmed
  83. Ehrlich L, Medina G, Photiadis S, Whittredge P, Watanabe S, Taraska J, et al. Tsg101 regulates PI(4,5)P2/Ca(2+) signaling for HIV-1 Gag assembly. Front Microbiol. 2014;5:234 pubmed publisher
    Our previous studies identified the 1,4,5-inositol trisphosphate receptor (IP3R), a channel mediating release of Ca(2+) from ER stores, as a cellular factor differentially associated with HIV-1 Gag that might facilitate ESCRT function in ..
  84. Roach J, Deutsch K, Li S, Siegel A, Bekris L, Einhaus D, et al. Genetic mapping at 3-kilobase resolution reveals inositol 1,4,5-triphosphate receptor 3 as a risk factor for type 1 diabetes in Sweden. Am J Hum Genet. 2006;79:614-27 pubmed
    ..MHC, we identified a peak of association within the inositol 1,4,5-triphosphate receptor 3 gene (ITPR3; formerly IP3R3). The most significant single SNP in this region was at the center of the ITPR3 peak of association (P=1...
  85. Nagaleekar V, DIEHL S, Juncadella I, Charland C, Muthusamy N, Eaton S, et al. IP3 receptor-mediated Ca2+ release in naive CD4 T cells dictates their cytokine program. J Immunol. 2008;181:8315-22 pubmed
    ..Thus, IP(3)Rs play a key role in the activation and differentiation of CD4 T cells. The immunosuppressive effect of pharmacological blockers of these receptors may be complicated by promoting the development of inflammatory CD4 T cells. ..
  86. Mahaut Smith M, Sage S, Rink T. Receptor-activated single channels in intact human platelets. J Biol Chem. 1990;265:10479-83 pubmed
    ..These channels may therefore provide an important mechanism for ADP to activate human platelets within a small fraction of a second. ..
  87. Berridge M, Lipp P, Bootman M. The versatility and universality of calcium signalling. Nat Rev Mol Cell Biol. 2000;1:11-21 pubmed
    ..Exceeding its normal spatial and temporal boundaries can result in cell death through both necrosis and apoptosis. ..
  88. Mizuno K, Kurokawa K, Ohkuma S. Regulatory mechanisms and pathophysiological significance of IP3 receptors and ryanodine receptors in drug dependence. J Pharmacol Sci. 2013;123:306-11 pubmed
    ..Although previous reports showed that the most important regulators of both RyR and IP3R channel functions are changes in the intracellular Ca(2+) concentration and in phosphorylation of these channels by ..
  89. Rong Y, Bultynck G, Aromolaran A, Zhong F, Parys J, De Smedt H, et al. The BH4 domain of Bcl-2 inhibits ER calcium release and apoptosis by binding the regulatory and coupling domain of the IP3 receptor. Proc Natl Acad Sci U S A. 2009;106:14397-402 pubmed publisher
    ..BH4 peptide binds to the regulatory and coupling domain of the IP3 receptor and inhibits IP3-dependent channel opening, Ca(2+) release from the ER, and Ca(2+)-mediated apoptosis...
  90. Wang X, Peng X, Zhang X, Xu H, Lu C, Liu L, et al. The Emerging Roles of CIB1 in Cancer. Cell Physiol Biochem. 2017;43:1413-1424 pubmed publisher
    ..calcium or modulating some key modulators, such as calcineurin, integrin, inositol 1,4,5-trisphosphate receptor (IP3R) and taste 1 receptor member 2 (TAS1R2)...
  91. Garcia Elias A, Lorenzo I, Vicente R, Valverde M. IP3 receptor binds to and sensitizes TRPV4 channel to osmotic stimuli via a calmodulin-binding site. J Biol Chem. 2008;283:31284-8 pubmed publisher
    ..We now search for the IP3 receptor-binding site on TRPV4 and its relevance to IP3-mediated sensitization...
  92. Huang Y, Lin Y, Chang J, Chen S, Wan L, Sheu J, et al. Single nucleotide polymorphism rs2229634 in the ITPR3 gene is associated with the risk of developing coronary artery aneurysm in children with Kawasaki disease. Int J Immunogenet. 2010;37:439-43 pubmed publisher
    ..The inositol 1,4,5-triphosphate receptor type 3 (ITPR3) gene has a strong association with the development of type 1 diabetes and, plays a critical role in the ..