Gene Symbol: ITPR1
Description: inositol 1,4,5-trisphosphate receptor type 1
Alias: ACV, CLA4, INSP3R1, IP3R, IP3R1, PPP1R94, SCA15, SCA16, SCA29, inositol 1,4,5-trisphosphate receptor type 1, IP3 receptor, IP3R 1, inositol 1,4,5-triphosphate receptor, type 1, protein phosphatase 1, regulatory subunit 94, type 1 InsP3 receptor, type 1 inositol 1,4,5-trisphosphate receptor
Species: human
Products:     ITPR1

Top Publications

  1. Cui J, Matkovich S, deSouza N, Li S, Rosemblit N, Marks A. Regulation of the type 1 inositol 1,4,5-trisphosphate receptor by phosphorylation at tyrosine 353. J Biol Chem. 2004;279:16311-6 pubmed
    ..We have identified tyrosine 353 (Tyr353) in the IP3-binding domain of type 1 IP3R (IP3R1) as a phosphorylation site for Fyn both in vitro and in vivo...
  2. Berridge M, Lipp P, Bootman M. The versatility and universality of calcium signalling. Nat Rev Mol Cell Biol. 2000;1:11-21 pubmed
    ..Exceeding its normal spatial and temporal boundaries can result in cell death through both necrosis and apoptosis. ..
  3. van de Leemput J, Chandran J, Knight M, Holtzclaw L, Scholz S, Cookson M, et al. Deletion at ITPR1 underlies ataxia in mice and spinocerebellar ataxia 15 in humans. PLoS Genet. 2007;3:e108 pubmed
    ..Spinocerebellar ataxia 15 (SCA15), a human autosomal dominant disorder, maps to the genomic region containing ITPR1; however, to date no causal ..
  4. deSouza N, Cui J, Dura M, McDonald T, Marks A. A function for tyrosine phosphorylation of type 1 inositol 1,4,5-trisphosphate receptor in lymphocyte activation. J Cell Biol. 2007;179:923-34 pubmed
    ..However, a major isoform in lymphocyte ER, IP3R1, is inhibited by elevated levels of cytosolic Ca2+, and the mechanism that enables the prolonged activation of IP(..
  5. Vicencio J, Ortiz C, Criollo A, Jones A, Kepp O, Galluzzi L, et al. The inositol 1,4,5-trisphosphate receptor regulates autophagy through its interaction with Beclin 1. Cell Death Differ. 2009;16:1006-17 pubmed publisher
    ..These results identify IP(3)R as a new regulator of the Beclin 1 complex that may bridge signals converging on the ER and initial phagophore formation. ..
  6. Ehrlich L, Carter C. HIV Assembly and Budding: Ca(2+) Signaling and Non-ESCRT Proteins Set the Stage. Mol Biol Int. 2012;2012:851670 pubmed publisher
    ..Parallel paradigms for non-ESCRT roles in virus budding and cytokinesis will be discussed. ..
  7. Dudding T, Friend K, Schofield P, Lee S, Wilkinson I, Richards R. Autosomal dominant congenital non-progressive ataxia overlaps with the SCA15 locus. Neurology. 2004;63:2288-92 pubmed
    ..Most patients with pure nonprogressive congenital cerebellar ataxia have a sporadic form of unknown heredity and etiology. Several small families have been reported with a dominantly inherited nonprogressive congenital ataxia (NPCA)...
  8. Chang N, Nguyen M, Germain M, Shore G. Antagonism of Beclin 1-dependent autophagy by BCL-2 at the endoplasmic reticulum requires NAF-1. EMBO J. 2010;29:606-18 pubmed publisher
    ..NAF-1 is required in this pathway for BCL-2 at the ER to functionally antagonize Beclin 1-dependent autophagy. Thus, NAF-1 is a BCL-2-associated co-factor that targets BCL-2 for antagonism of the autophagy pathway at the ER. ..
  9. Synofzik M, Beetz C, Bauer C, Bonin M, Sánchez Ferrero E, Schmitz Hubsch T, et al. Spinocerebellar ataxia type 15: diagnostic assessment, frequency, and phenotypic features. J Med Genet. 2011;48:407-12 pubmed publisher
    ..Fifty-six German SCA families negative for common repeat expansions were screened for ITPR1 deletions by MLPA...

More Information

Publications104 found, 100 shown here

  1. Jones C, Bray S, Garner S, Stephens J, de Bono B, Angenent W, et al. A functional genomics approach reveals novel quantitative trait loci associated with platelet signaling pathways. Blood. 2009;114:1405-16 pubmed publisher
    ..004). Furthermore the minor allele of the intronic SNP rs17786144 in ITPR1 modified Ca(2+) levels after activation with ADP (P < .004)...
  2. Ehrlich L, Medina G, Khan M, Powell M, Mikoshiba K, Carter C. Activation of the inositol (1,4,5)-triphosphate calcium gate receptor is required for HIV-1 Gag release. J Virol. 2010;84:6438-51 pubmed publisher
    ..The inositol (1,4,5)-triphosphate receptor (IP3R) gates intracellular Ca(2+) stores...
  3. Ehrlich L, Medina G, Carter C. Sprouty2 regulates PI(4,5)P2/Ca2+ signaling and HIV-1 Gag release. J Mol Biol. 2011;410:716-25 pubmed publisher
    We reported recently that activation of the inositol 1,4,5-triphosphate receptor (IP3R) is required for efficient HIV-1 Gag trafficking and viral particle release...
  4. Storey E, Gardner R, Knight M, Kennerson M, Tuck R, Forrest S, et al. A new autosomal dominant pure cerebellar ataxia. Neurology. 2001;57:1913-5 pubmed
    ..Pending an actual chromosomal locus discovery, the name spinocerebellar ataxia (SCA)15 is expectantly applied. ..
  5. Hirota J, Ando H, Hamada K, Mikoshiba K. Carbonic anhydrase-related protein is a novel binding protein for inositol 1,4,5-trisphosphate receptor type 1. Biochem J. 2003;372:435-41 pubmed
    ..This could be due to co-expression of CARP with IP(3)R in Purkinje cells and its inhibitory effects on IP(3) binding. ..
  6. Kiselyov K, Xu X, Mozhayeva G, Kuo T, Pessah I, Mignery G, et al. Functional interaction between InsP3 receptors and store-operated Htrp3 channels. Nature. 1998;396:478-82 pubmed
    ..Our results provide evidence for the coupling hypothesis, in which InsP3 receptors activated by InsP3 interact with SOC and regulate I(crac). ..
  7. Ando H, Mizutani A, Matsu ura T, Mikoshiba K. IRBIT, a novel inositol 1,4,5-trisphosphate (IP3) receptor-binding protein, is released from the IP3 receptor upon IP3 binding to the receptor. J Biol Chem. 2003;278:10602-12 pubmed
    ..These results suggest that IRBIT is released from activated IP(3)R, raising the possibility that IRBIT acts as a signaling molecule downstream from IP(3)R. ..
  8. Iwaki A, Kawano Y, Miura S, Shibata H, Matsuse D, Li W, et al. Heterozygous deletion of ITPR1, but not SUMF1, in spinocerebellar ataxia type 16. J Med Genet. 2008;45:32-5 pubmed
    ..Recently, partial deletions of ITPR1 and the neighbouring SUMF1 in the SCA15 and two additional families were reported...
  9. Rong Y, Aromolaran A, Bultynck G, Zhong F, Li X, McColl K, et al. Targeting Bcl-2-IP3 receptor interaction to reverse Bcl-2's inhibition of apoptotic calcium signals. Mol Cell. 2008;31:255-65 pubmed publisher
    ..One proposed mechanism involves an interaction of Bcl-2 with the inositol 1,4,5-trisphosphate receptor (IP3R) Ca2+ channel localized with Bcl-2 on the ER...
  10. Huang L, Chardon J, Carter M, Friend K, Dudding T, Schwartzentruber J, et al. Missense mutations in ITPR1 cause autosomal dominant congenital nonprogressive spinocerebellar ataxia. Orphanet J Rare Dis. 2012;7:67 pubmed publisher
    ..was performed for the Australian family, resulting in the identification of a heterozygous mutation in the ITPR1 gene...
  11. Ando H, Mizutani A, Kiefer H, Tsuzurugi D, Michikawa T, Mikoshiba K. IRBIT suppresses IP3 receptor activity by competing with IP3 for the common binding site on the IP3 receptor. Mol Cell. 2006;22:795-806 pubmed
    ..We previously identified an IP3R binding protein, IRBIT, which binds to the IP3 binding domain of IP3R and is dissociated from IP3R in the presence ..
  12. Criollo A, Maiuri M, Tasdemir E, Vitale I, Fiebig A, Andrews D, et al. Regulation of autophagy by the inositol trisphosphate receptor. Cell Death Differ. 2007;14:1029-39 pubmed
    ..Altogether, these results strongly suggest that IP(3)R exerts a major role in the physiological control of autophagy. ..
  13. Hara K, Shiga A, Nozaki H, Mitsui J, Takahashi Y, Ishiguro H, et al. Total deletion and a missense mutation of ITPR1 in Japanese SCA15 families. Neurology. 2008;71:547-51 pubmed publisher
    Spinocerebellar ataxia type 15 (SCA15) is a progressive neurodegenerative disorder characterized by pure cerebellar ataxia, very slow progression, and distinct cerebellar atrophy. The locus for SCA15 was first mapped to 3p24...
  14. Rong Y, Bultynck G, Aromolaran A, Zhong F, Parys J, De Smedt H, et al. The BH4 domain of Bcl-2 inhibits ER calcium release and apoptosis by binding the regulatory and coupling domain of the IP3 receptor. Proc Natl Acad Sci U S A. 2009;106:14397-402 pubmed publisher
    ..BH4 peptide binds to the regulatory and coupling domain of the IP3 receptor and inhibits IP3-dependent channel opening, Ca(2+) release from the ER, and Ca(2+)-mediated apoptosis...
  15. Knight M, Kennerson M, Anney R, Matsuura T, Nicholson G, Salimi Tari P, et al. Spinocerebellar ataxia type 15 (sca15) maps to 3p24.2-3pter: exclusion of the ITPR1 gene, the human orthologue of an ataxic mouse mutant. Neurobiol Dis. 2003;13:147-57 pubmed
    We have studied a large Australian kindred with a dominantly inherited pure cerebellar ataxia, SCA15. The disease is characterised by a very slow rate of progression in some family members, and atrophy predominantly of the superior ..
  16. MacMillan D, Currie S, Bradley K, Muir T, McCarron J. In smooth muscle, FK506-binding protein modulates IP3 receptor-evoked Ca2+ release by mTOR and calcineurin. J Cell Sci. 2005;118:5443-51 pubmed
    ..Release from the IP3R may be modulated by endogenous proteins associated with the receptor, such as the 12 kDa FK506-binding protein (..
  17. Yokoyama K, Su Ih I, Tezuka T, Yasuda T, Mikoshiba K, Tarakhovsky A, et al. BANK regulates BCR-induced calcium mobilization by promoting tyrosine phosphorylation of IP(3) receptor. EMBO J. 2002;21:83-92 pubmed
    ..Because BANK expression is confined to functional BCR-expressing B cells, BANK-mediated calcium mobilization may be specific to foreign antigen-induced immune responses rather than to signaling required for B-cell development. ..
  18. Kawaai K, Hisatsune C, Kuroda Y, Mizutani A, Tashiro T, Mikoshiba K. 80K-H interacts with inositol 1,4,5-trisphosphate (IP3) receptors and regulates IP3-induced calcium release activity. J Biol Chem. 2009;284:372-80 pubmed publisher
    ..80K-H directly interacted with IP3R type 1 (IP3R1) in vitro and co-immunoprecipitated with IP3R1 in cell lysates...
  19. Canet Pons J, Schubert R, Duecker R, Schrewe R, Wölke S, Kieslich M, et al. Ataxia telangiectasia alters the ApoB and reelin pathway. Neurogenetics. 2018;19:237-255 pubmed publisher climbing fiber markers, glutamate receptors like Grin2b, and calcium homeostasis factors (Atp2b2, Calb1, Itpr1), while factors involved in DNA damage, oxidative stress, neuroinflammation, and cell adhesion were normal at this ..
  20. Koriauli S, Natsvlishvili N, Barbakadze T, Mikeladze D. Knockdown of interleukin-10 induces the redistribution of sigma1-receptor and increases the glutamate-dependent NADPH-oxidase activity in mouse brain neurons. Biol Res. 2015;48:55 pubmed publisher
    ..C3 botulinum toxin substrate 1), NR2B subunit of NMDA-receptor (NMDAR) and inositol-3-phosphate receptor (IP3R) is higher in the IL-10 KO mice brain than in the Wt mice brain...
  21. Jarius S, Metz I, König F, Ruprecht K, Reindl M, Paul F, et al. Screening for MOG-IgG and 27 other anti-glial and anti-neuronal autoantibodies in 'pattern II multiple sclerosis' and brain biopsy findings in a MOG-IgG-positive case. Mult Scler. 2016;22:1541-1549 pubmed
    ..anti-Ca/RhoGTPase-activating protein 26 (ARHGAP26), anti-Sj/inositol-1,4,5-trisphosphate receptor 1 (ITPR1), anti-Homer3, anti-carbonic anhydrase-related protein (CARPVIII), anti-protein kinase gamma (PKCgamma), anti-..
  22. Jarius S, Wildemann B. 'Medusa-head ataxia': the expanding spectrum of Purkinje cell antibodies in autoimmune cerebellar ataxia. Part 1: Anti-mGluR1, anti-Homer-3, anti-Sj/ITPR1 and anti-CARP VIII. J Neuroinflammation. 2015;12:166 pubmed publisher
  23. Chantong B, Kratschmar D, Lister A, Odermatt A. Inhibition of metabotropic glutamate receptor 5 induces cellular stress through pertussis toxin-sensitive Gi-proteins in murine BV-2 microglia cells. J Neuroinflammation. 2014;11:190 pubmed publisher
    ..elevation of [Ca(2+)]i, following Ca(2+) release from the ER, mainly via inositol triphosphate-induced receptors (IP3R)...
  24. Contreras Ferrat A, Lavandero S, Jaimovich E, Klip A. Calcium signaling in insulin action on striated muscle. Cell Calcium. 2014;56:390-6 pubmed publisher
    ..e., the Ryanodine Receptor (RyR) and the inositol 1,4,5-triphosphate receptor (IP3R)...
  25. Song Q, Gou W, Zou Y. FAM3A Protects Against Glutamate-Induced Toxicity by Preserving Calcium Homeostasis in Differentiated PC12 Cells. Cell Physiol Biochem. 2017;44:2029-2041 pubmed publisher
    ..also inhibited the intracellular Ca2+ release mediated by mGluR1/5 and inositol 1,4,5-trisphosphate receptor (IP3R), but not the ryanodine receptor (RyR)...
  26. Yoo S, Huh Y, Hur Y. Inositol 1,4,5-trisphosphate receptor in chromaffin secretory granules and its relation to chromogranins. Cell Mol Neurobiol. 2010;30:1155-61 pubmed publisher
    ..Coupled chromogranins change the IP(3)R/Ca(2+) channels to a more ordered, release-ready state, whereby making the IP(3)R/Ca(2+) channels significantly more sensitive to IP(3). ..
  27. Storey E, Gardner R. Spinocerebellar ataxia type 15. Handb Clin Neurol. 2012;103:561-5 pubmed publisher
    ..SCA15 is due to various deletions of the inositol 1,4,5-triphosphate receptor 1 gene (ITPR1) on the distal short arm of chromosome 3...
  28. Elkoreh G, Blais V, Béliveau E, Guillemette G, Denault J. Type 1 inositol-1,4,5-trisphosphate receptor is a late substrate of caspases during apoptosis. J Cell Biochem. 2012;113:2775-84 pubmed publisher
    ..Finally, using recombinant caspase-3 and microsomal fractions enriched in IP(3) R-1, we show that the receptor is a poor caspase-3 substrate. Consequently, we conclude that IP(3) R-1 is not a key death substrate. ..
  29. Vervliet T, Parys J, Bultynck G. Bcl-2 and FKBP12 bind to IP3 and ryanodine receptors at overlapping sites: the complexity of protein-protein interactions for channel regulation. Biochem Soc Trans. 2015;43:396-404 pubmed publisher
    ..Nevertheless, conservation of these residues in the different IP3R isoforms and during evolution suggested that they could harbour an important regulatory site critical for IP3R-..
  30. Zhang N, Yoon S, Parys J, Fissore R. Effect of M-phase kinase phosphorylations on type 1 inositol 1,4,5-trisphosphate receptor-mediated Ca2+ responses in mouse eggs. Cell Calcium. 2015;58:476-88 pubmed publisher
    The type 1 inositol 1,4,5-trisphosphate receptor (IP3R1) mediates increases in the intracellular concentration of Ca(2+) ([Ca(2+)]i) during fertilization in mammalian eggs...
  31. Berens A, Tibbetts E, Toth A. Candidate genes for individual recognition in Polistes fuscatus paper wasps. J Comp Physiol A Neuroethol Sens Neural Behav Physiol. 2016;202:115-29 pubmed publisher
    ..We identified four candidate genes (IP3K, IP3R, Nckx30C and Su(var)2-10) that were down-regulated in the presence of familiar individuals compared to single wasps ..
  32. Guo Z, Zhang Y, Xie G, Liu C, Zhou R, Shi W. Down-regulation of Homer1 attenuates t-BHP-induced oxidative stress through regulating calcium homeostasis and ER stress in brain endothelial cells. Biochem Biophys Res Commun. 2016;477:970-976 pubmed publisher
    ..The results of Ca(2+) imaging showed that Homer1 was involved in inositol trisphosphate receptors (IP3R)- and ryanodine receptor (RyR)-mediated intracellular Ca(2+) release, and also mediated t-BHP-induced Ca(2+) ..
  33. Yang W, Qi Y, Fu J. Genetic signals of high-altitude adaptation in amphibians: a comparative transcriptome analysis. BMC Genet. 2016;17:134 pubmed
    ..other nutrient metabolism related genes for signatures of natural selection, and found that two genes, CAPN2 and ITPR1, were likely under balancing selection...
  34. Mahaut Smith M, Sage S, Rink T. Receptor-activated single channels in intact human platelets. J Biol Chem. 1990;265:10479-83 pubmed
    ..These channels may therefore provide an important mechanism for ADP to activate human platelets within a small fraction of a second. ..
  35. Bandyopadhyay B, Swaim W, Liu X, Redman R, Patterson R, Ambudkar I. Apical localization of a functional TRPC3/TRPC6-Ca2+-signaling complex in polarized epithelial cells. Role in apical Ca2+ influx. J Biol Chem. 2005;280:12908-16 pubmed
    ..These data demonstrate functional localization of TRPC3/TRPC6 channels in the apical region of polarized epithelial cells. In salivary gland ducts this could contribute to the regulation of salivary [Ca2+] and secretion. ..
  36. Macvicar T, Mannack L, Lees R, Lane J. Targeted siRNA Screens Identify ER-to-Mitochondrial Calcium Exchange in Autophagy and Mitophagy Responses in RPE1 Cells. Int J Mol Sci. 2015;16:13356-80 pubmed publisher
    ..Further experiments suggested that IP3R-mediated transfer of Ca2+ from the ER lumen to the mitochondrial matrix via the mitochondrial Ca2+ uniporter (MCU) ..
  37. Jiang M, Wan F, Wang F, Wu Q. Irisin relaxes mouse mesenteric arteries through endothelium-dependent and endothelium-independent mechanisms. Biochem Biophys Res Commun. 2015;468:832-6 pubmed publisher
    ..Endothelium-independent relaxation may be depend on inhibiting Ca(2+) influx through blocking VDCCs and intracellular Ca(2+) release through both IP3R and RyR channels.
  38. Wu J, Ryskamp D, Liang X, Egorova P, Zakharova O, Hung G, et al. Enhanced Store-Operated Calcium Entry Leads to Striatal Synaptic Loss in a Huntington's Disease Mouse Model. J Neurosci. 2016;36:125-41 pubmed publisher
    ..We previously discovered that mHtt protein binds to type 1 inositol (1,4,5)-trisphosphate receptor (InsP3R1) and increases its sensitivity to activation by InsP3...
  39. Uchida K, Nakazawa M, Yamagishi C, Mikoshiba K, Yamagishi H. Type 1 and 3 inositol trisphosphate receptors are required for extra-embryonic vascular development. Dev Biol. 2016;418:89-97 pubmed publisher
    ..Double knockout (DKO) of type 1 and 3 IP3Rs (IP3R1 and IP3R3, respectively) in mice resulted in embryonic lethality around embryonic day (E) 11.5...
  40. Srivastava R, Li C, Ahmad A, Abrams O, Gorbatyuk M, Harrod K, et al. ATF4 regulates arsenic trioxide-mediated NADPH oxidase, ER-mitochondrial crosstalk and apoptosis. Arch Biochem Biophys. 2016;609:39-50 pubmed publisher
    ..The IP3R inhibitor attenuates Ca++/calpain-dependent apoptosis, as well as reduces m-ROS and MMP disruption, ..
  41. Komalavilas P, Lincoln T. Phosphorylation of the inositol 1,4,5-trisphosphate receptor by cyclic GMP-dependent protein kinase. J Biol Chem. 1994;269:8701-7 pubmed
    ..inhibits inositol 1,4,5-trisphosphate (IP3) action, we examined the effects of cGMP-dependent protein kinase on IP3 receptor phosphorylation...
  42. Yang J, McBride S, Mak D, Vardi N, Palczewski K, Haeseleer F, et al. Identification of a family of calcium sensors as protein ligands of inositol trisphosphate receptor Ca(2+) release channels. Proc Natl Acad Sci U S A. 2002;99:7711-6 pubmed
  43. Murthy K, Zhou H. Selective phosphorylation of the IP3R-I in vivo by cGMP-dependent protein kinase in smooth muscle. Am J Physiol Gastrointest Liver Physiol. 2003;284:G221-30 pubmed
    ..We conclude that IP(3)R-I is selectively phosphorylated by PKG-I in intact smooth muscle resulting in inhibition of IP(3)-dependent Ca(2+) release. ..
  44. van Rossum D, Patterson R, Cheung K, Barrow R, Syrovatkina V, Gessell G, et al. DANGER, a novel regulatory protein of inositol 1,4,5-trisphosphate-receptor activity. J Biol Chem. 2006;281:37111-6 pubmed
    ..DANGER appears to allosterically modulate the sensitivity of IP(3) RtoCa(2+) inhibition, which likely alters IP(3)R-mediated Ca(2+) dynamics in cells where DANGER and IP(3)R are co-expressed. ..
  45. Kudryavtseva O, Aalkjær C, Bek T. Prostaglandin induced changes in the tone of porcine retinal arterioles in vitro involve other factors than calcium activity in perivascular cells. Exp Eye Res. 2015;138:96-103 pubmed publisher
    ..LOE908, the sarcoplasmic reticulum Ca(2+)-ATPase (SERCA) blocker CPA, and the inositol triphosphate receptor (IP3R) and transient receptor potential (TRP) ion channel blocker 2-APB...
  46. Wright F, Wojcikiewicz R. Chapter 4 - Inositol 1,4,5-Trisphosphate Receptor Ubiquitination. Prog Mol Biol Transl Sci. 2016;141:141-59 pubmed publisher
    ..of ubiquitin conjugates, that this ubiquitination and degradation functions to regulate IP3-mediated Ca(2+) responses in the cell, and that mutations to different proteins involved in IP3R degradation result in a set of similar diseases.
  47. Singh K, Briggs J. Functional Implications of the spectrum of BCL2 mutations in Lymphoma. Mutat Res Rev Mutat Res. 2016;769:1-18 pubmed publisher member proteins crucial for 1) maintaining mitochondrial energetics and calcium hemostasis such as VDAC, IP3R, and RyR and 2) oncogenic pathways implicated in the acquisition of the 'hallmarks of cancer' such as SOD, Raf-1, ..
  48. Nguyen N, Francoeur N, Chartrand V, Klarskov K, Guillemette G, Boulay G. Insulin promotes the association of heat shock protein 90 with the inositol 1,4,5-trisphosphate receptor to dampen its Ca2+ release activity. Endocrinology. 2009;150:2190-6 pubmed publisher
    ..These results demonstrate that insulin promotes the interaction of Hsp90 with the IP(3)R to dampen its Ca(2+) release activity by a complex mechanism involving mammalian target of rapamycin and the Src kinase. ..
  49. Tabatadze N, Huang G, May R, Jain A, Woolley C. Sex Differences in Molecular Signaling at Inhibitory Synapses in the Hippocampus. J Neurosci. 2015;35:11252-65 pubmed publisher
    ..mGluR1 stimulation of phospholipase C, leading to inositol triphosphate (IP3) generation, activation of the IP3 receptor (IP3R), and postsynaptic endocannabinoid release, likely of anandamide...
  50. Teos L, Zhang Y, Cotrim A, Swaim W, Won J, Ambrus J, et al. IP3R deficit underlies loss of salivary fluid secretion in Sjögren's Syndrome. Sci Rep. 2015;5:13953 pubmed publisher
    ..Importantly, these acini displayed reduction in IP3R2 and IP3R3, but not AQP5 or STIM1. Similar decreases in IP3R and carbachol (CCh)-stimulated [Ca(2+)]i elevation were detected in acinar cells from lymphotoxin-alpha (LTα) ..
  51. Franco Salla G, Prates J, Cardin L, Dos Santos A, Silva W, da Cunha B, et al. Euphorbia tirucalli modulates gene expression in larynx squamous cell carcinoma. BMC Complement Altern Med. 2016;16:136 pubmed publisher
    ..The RaSH showed change in the expression of some genes, including ANXA1, TCEA1, NGFRAP1, ITPR1 and CD55, which are associated with inflammatory response, transcriptional regulation, apoptosis, calcium ion ..
  52. Jarius S, Ringelstein M, Haas J, Serysheva I, Komorowski L, Fechner K, et al. Inositol 1,4,5-trisphosphate receptor type 1 autoantibodies in paraneoplastic and non-paraneoplastic peripheral neuropathy. J Neuroinflammation. 2016;13:278 pubmed
    Recently, we described a novel autoantibody, anti-Sj/ITPR1-IgG, that targets the inositol 1,4,5-trisphosphate receptor type 1 (ITPR1) in patients with cerebellar ataxia...
  53. Yu Y, Xie Q, Liu W, Guo Y, Xu N, Xu L, et al. Increased intracellular Ca2+ decreases cisplatin resistance by regulating iNOS expression in human ovarian cancer cells. Biomed Pharmacother. 2017;86:8-15 pubmed publisher
    ..TAT-conjugated IP3R-derived peptide (TAT-IDPS) increased cisplatin-induced iNOS expression and apoptosis in SKOV3/DDP cells...
  54. Yao J, Pilko A, Wollman R. Distinct cellular states determine calcium signaling response. Mol Syst Biol. 2016;12:894 pubmed publisher
    ..The inferred parameter distribution predicts, and experiments confirm that variability in IP3R response explains the majority of calcium heterogeneity...
  55. Wang M, Tan J, Miao Y, Li M, Zhang Q. Role of Ca²? and ion channels in the regulation of apoptosis under hypoxia. Histol Histopathol. 2018;33:237-246 pubmed publisher
    ..Na?/ Ca²? Exchanger (NCX), L-type voltage dependent Ca²? channel (L-VDCC), inositol triphosphate receptors (IP3R) and so on, which contribute to intracellular Ca²? overload, thus eventually triggering cell apoptosis...
  56. Stobart J, Ferrari K, Barrett M, Stobart M, Looser Z, Saab A, et al. Long-term In Vivo Calcium Imaging of Astrocytes Reveals Distinct Cellular Compartment Responses to Sensory Stimulation. Cereb Cortex. 2018;28:184-198 pubmed publisher
    ..Although mice genetically lacking astrocytic IP3R-dependent calcium signaling (Ip3r2-/-) had fewer signal peaks, the response to sensory stimulation was sustained, ..
  57. Xiao W, Zhang J, Chen S, Shi Y, Xiao F, An W. Alleviation of palmitic acid-induced endoplasmic reticulum stress by augmenter of liver regeneration through IP3R-controlled Ca2+ release. J Cell Physiol. 2018;233:6148-6157 pubmed publisher
    ..The treatment of HepG2 cells with palmitic acid (PA) upregulated IP3R expression, triggering ER-luminal Ca2+ release and inducing ER stress...
  58. Trebak M, St J Bird G, McKay R, Birnbaumer L, Putney J. Signaling mechanism for receptor-activated canonical transient receptor potential 3 (TRPC3) channels. J Biol Chem. 2003;278:16244-52 pubmed
    ..We conclude that receptor-mediated activation of phospholipase C in intact cells activates TRPC3 via diacylglycerol production, independently of G proteins, protein kinase C, or inositol 1,4,5-trisphosphate. ..
  59. Mak D, Cheung K, Toglia P, Foskett J, Ullah G. Analyzing and Quantifying the Gain-of-Function Enhancement of IP3 Receptor Gating by Familial Alzheimer's Disease-Causing Mutants in Presenilins. PLoS Comput Biol. 2015;11:e1004529 pubmed publisher
    ..disease (FAD)-causing mutant presenilins (PS) interact with inositol 1,4,5-trisphosphate (IP3) receptor (IP3R) Ca(2+) release channels resulting in enhanced IP3R channel gating in an amyloid beta (Aβ) production-independent ..
  60. Burlaka I, Nilsson L, Scott L, Holtback U, Eklöf A, Fogo A, et al. Prevention of apoptosis averts glomerular tubular disconnection and podocyte loss in proteinuric kidney disease. Kidney Int. 2016;90:135-48 pubmed publisher
    ..Our group has described an ouabain-activated Na,K-ATPase/IP3R signalosome, which protects from apoptosis...
  61. Mery L, Magnino F, Schmidt K, Krause K, Dufour J. Alternative splice variants of hTrp4 differentially interact with the C-terminal portion of the inositol 1,4,5-trisphosphate receptors. FEBS Lett. 2001;487:377-83 pubmed
    ..Thus, we describe a novel interaction between Trp proteins and InsP3R and we provide evidence suggesting that the formation of hTrp4-InsP3R complexes may be regulated by alternative splicing. ..
  62. Di Gregorio E, Orsi L, Godani M, Vaula G, Jensen S, Salmon E, et al. Two Italian families with ITPR1 gene deletion presenting a broader phenotype of SCA15. Cerebellum. 2010;9:115-23 pubmed publisher
    Spinocerebellar ataxia type15 (SCA15) is a pure ataxia characterized by very slow progression...
  63. Parys J, Decuypere J, Bultynck G. Role of the inositol 1,4,5-trisphosphate receptor/Ca2+-release channel in autophagy. Cell Commun Signal. 2012;10:17 pubmed publisher
    ..In contrast, Ca2+-induced autophagy can be mediated by several pathways including calmodulin-dependent kinase kinase ?, calmodulin-dependent kinase I, protein kinase C ?, and/or extracellular signal-regulated kinase. ..
  64. Liu F, Liou J, Liao H, Mao C, Yang P, Day Y. The anti-aggregation effects of ondansetron on platelets involve IP3 signaling and MAP kinase pathway, but not 5-HT3-dependent pathway. Thromb Res. 2012;130:e84-94 pubmed publisher
  65. Rex E, Rankin M, Yang Y, Lu Q, Gerfen C, Jose P, et al. Identification of RanBP 9/10 as interacting partners for protein kinase C (PKC) gamma/delta and the D1 dopamine receptor: regulation of PKC-mediated receptor phosphorylation. Mol Pharmacol. 2010;78:69-80 pubmed publisher
    ..These data support the idea that RanBP9 and RanBP10 may function as signaling integrators and dictate the efficient regulation of D(1) receptor signaling by PKCdelta and PKCgamma. ..
  66. Das J, Lilleker J, Shereef H, Ealing J. Missense mutation in the ITPR1 gene presenting with ataxic cerebral palsy: Description of an affected family and literature review. Neurol Neurochir Pol. 2017;51:497-500 pubmed publisher
    The inositol 1,4,5-triphosphate receptor type 1 (ITPR1) gene on chromosome 3 belongs to a family of genes encoding intracellular calcium channel proteins...
  67. Carvalho D, Medeiros J, Ribeiro D, Martins B, Sobreira N. Additional features of Gillespie syndrome in two Brazilian siblings with a novel ITPR1 homozygous pathogenic variant. Eur J Med Genet. 2018;61:134-138 pubmed publisher
    ..The typical iris anomaly is considered necessary to the diagnosis of GS. Recently, variants in ITPR1 were described causing GS. Non-neurological features were reported in few patients...
  68. Haynes L, Tepikin A, Burgoyne R. Calcium-binding protein 1 is an inhibitor of agonist-evoked, inositol 1,4,5-trisphosphate-mediated calcium signaling. J Biol Chem. 2004;279:547-55 pubmed
    ..Together, these data suggest that L-CaBP1 is able to specifically regulate InsP3 receptor-mediated alterations in [Ca2+]i during agonist stimulation. ..
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  70. Tarui T, Kim A, Flake A, McClain L, Stratigis J, Fried I, et al. Amniotic fluid transcriptomics reflects novel disease mechanisms in fetuses with myelomeningocele. Am J Obstet Gynecol. 2017;217:587.e1-587.e10 pubmed publisher
    ..significant contribution of inflammation to disease and a broad influence of Wnt signaling pathways (Wnt1, Wnt5A, ITPR1)...
  71. Quinton T, Dean W. Multiple inositol 1,4,5-trisphosphate receptor isoforms are present in platelets. Biochem Biophys Res Commun. 1996;224:740-6 pubmed
  72. Wozniak A, Wang X, Stieren E, Scarbrough S, Elferink C, Boehning D. Requirement of biphasic calcium release from the endoplasmic reticulum for Fas-mediated apoptosis. J Cell Biol. 2006;175:709-14 pubmed
    ..on phospholipase C-gamma1 (PLC-gamma1) activation and Ca2+ release from inositol 1,4,5-trisphosphate receptor (IP3R) channels...
  73. Meena A, Tovey S, Taylor C. Sustained signalling by PTH modulates IP3 accumulation and IP3 receptors through cyclic AMP junctions. J Cell Sci. 2015;128:408-20 pubmed publisher
    ..causes internalization of PTH1R-adenylyl cyclase signalling complexes, but the consequences for delivery of cAMP to IP3R within cAMP signalling junctions are unknown...
  74. Marelli C, van de Leemput J, Johnson J, Tison F, Thauvin Robinet C, Picard F, et al. SCA15 due to large ITPR1 deletions in a cohort of 333 white families with dominant ataxia. Arch Neurol. 2011;68:637-43 pubmed publisher
    Deletions in ITPR1, coding for the inositol-triphosphate receptor type 1, have been recently identified in spinocerebellar ataxia type 15 (SCA15). To determine the frequency and the phenotypical spectrum of SCA15...
  75. Belal C, Ameli N, El Kommos A, Bezalel S, Al Khafaji A, Mughal M, et al. The homocysteine-inducible endoplasmic reticulum (ER) stress protein Herp counteracts mutant ?-synuclein-induced ER stress via the homeostatic regulation of ER-resident calcium release channel proteins. Hum Mol Genet. 2012;21:963-77 pubmed publisher
    ..Our findings suggest a therapeutic potential in PD for agents that increase Herp levels or its ER Ca(2+)-stabilizing action. ..
  76. Lock J, Sinkins W, Schilling W. Protein S-glutathionylation enhances Ca2+-induced Ca2+ release via the IP3 receptor in cultured aortic endothelial cells. J Physiol. 2012;590:3431-47 pubmed publisher
    ..e. enhanced CICR, and suggest that glutathionylation may represent a fundamental mechanism for regulating IP(3)R activity during physiological redox signalling and during pathologicalical oxidative stress. ..
  77. Hwang H, Min H, Kim D, Yu S, Jung S, Choi S, et al. Imiquimod induces a Toll-like receptor 7-independent increase in intracellular calcium via IP(3) receptor activation. Biochem Biophys Res Commun. 2014;450:875-9 pubmed publisher
    ..However, 2APB, an IP3 receptor blocker, inhibited the imiquimod-induced [Ca(2+)]i increase...
  78. Ando H, Mizutani A, Mikoshiba K. An IRBIT homologue lacks binding activity to inositol 1,4,5-trisphosphate receptor due to the unique N-terminal appendage. J Neurochem. 2009;109:539-50 pubmed publisher
    ..These results suggest that Long-IRBIT has a different function from IRBIT. ..
  79. Li S, Wang Y, Zhao H, He Y, Li J, Jiang G, et al. NF-?B-mediated inflammation correlates with calcium overload under arsenic trioxide-induced myocardial damage in Gallus gallus. Chemosphere. 2017;185:618-627 pubmed publisher
    ..the mRNA levels of ITPR3, PMCA, TRPC1, TRPC3, STIM1, ORAI1 and pro-inflammatory genes, while the mRNA levels of ITPR1, ITPR2, RyR1, RyR3, SERCA, SLC8A1, CACNA1S and interleukin-10 were decreased (P < 0...
  80. Lencesova L, Hudecova S, Csaderova L, Markova J, Soltysova A, Pastorek M, et al. Sulphide signalling potentiates apoptosis through the up-regulation of IP3 receptor types 1 and 2. Acta Physiol (Oxf). 2013;208:350-61 pubmed publisher
    ..These results suggest an involvement of H2 S in both IP3 -induced calcium signalling and induction of apoptosis, possibly through the activation of ER stress. ..
  81. Jarius S, Scharf M, Begemann N, Stöcker W, Probst C, Serysheva I, et al. Antibodies to the inositol 1,4,5-trisphosphate receptor type 1 (ITPR1) in cerebellar ataxia. J Neuroinflammation. 2014;11:206 pubmed publisher
    ..binding pattern as well as double staining experiments suggested inositol 1,4,5-trisphosphate receptor type 1 (ITPR1) as the target antigen...
  82. Rivet C, Kniss James A, Gran M, Potnis A, Hill A, Lu H, et al. Calcium Dynamics of Ex Vivo Long-Term Cultured CD8+ T Cells Are Regulated by Changes in Redox Metabolism. PLoS ONE. 2016;11:e0159248 pubmed publisher
    ..Instead, modeling analysis identified kinetic parameters associated with the IP3R and STIM1 channels as potential causes for alterations in Ca2+ dynamics associated with the long term ex vivo ..
  83. Ritaine A, Shapovalov G, Prevarskaya N. Metabolic Disorders and Cancer: Store-Operated Ca2+ Entry in Cancer: Focus on IP3R-Mediated Ca2+ Release from Intracellular Stores and Its Role in Migration and Invasion. Adv Exp Med Biol. 2017;993:623-637 pubmed publisher
  84. Obayashi M, Ishikawa K, Izumi Y, Takahashi M, Niimi Y, Sato N, et al. Prevalence of inositol 1, 4, 5-triphosphate receptor type 1 gene deletion, the mutation for spinocerebellar ataxia type 15, in Japan screened by gene dosage. J Hum Genet. 2012;57:202-6 pubmed publisher
    Spinocerebellar ataxia type 15 (SCA15) is an autosomal dominant neurodegenerative disorder clinically characterized by late-onset, slowly progressive pure cerebellar ataxia...
  85. Santulli G, Marks A. Essential Roles of Intracellular Calcium Release Channels in Muscle, Brain, Metabolism, and Aging. Curr Mol Pharmacol. 2015;8:206-22 pubmed
    ..The ryanodine receptors (RyRs: RyR1, RyR2, RyR3) and inositol 1,4,5-trisphosphate receptors (IP3Rs: IP3R1, IP3R2, IP3R3) are the major Ca(2+) release channels (CRCs) on the endo/sarcoplasmic reticulum (ER/SR)...
  86. Johny J, Plank M, David T. Importance of Altered Levels of SERCA, IP3R, and RyR in Vascular Smooth Muscle Cell. Biophys J. 2017;112:265-287 pubmed publisher
    ..This research suggests that reduced SERCA level is the main factor responsible for the reduced intracellular calcium transients and contractility in VSMCs. ..
  87. Antl M, von Brühl M, Eiglsperger C, Werner M, Konrad I, Kocher T, et al. IRAG mediates NO/cGMP-dependent inhibition of platelet aggregation and thrombus formation. Blood. 2007;109:552-9 pubmed
    ..These findings reveal that interaction between IRAG and InsP3RI has a central role in NO/cGMP-dependent inhibition of platelet aggregation and in vivo thrombosis. ..
  88. Yaroslavskiy B, Sharrow A, Wells A, Robinson L, Blair H. Necessity of inositol (1,4,5)-trisphosphate receptor 1 and mu-calpain in NO-induced osteoclast motility. J Cell Sci. 2007;120:2884-94 pubmed
    ..We conclude that NO-induced motility in osteoclasts requires regulated Ca(2+) release, which activates mu-calpain. This occurs via the Ins(1,4,5)P(3)R1. ..
  89. Signore S, Sorrentino A, Ferreira Martins J, Kannappan R, Shafaie M, Del Ben F, et al. Inositol 1, 4, 5-trisphosphate receptors and human left ventricular myocytes. Circulation. 2013;128:1286-97 pubmed publisher
    ..b>IP3R function was determined in human left ventricular myocytes, and this analysis was integrated with assays in mouse ..
  90. PARK K, Yule D, Bowers W. Tumor necrosis factor-alpha-mediated regulation of the inositol 1,4,5-trisphosphate receptor promoter. J Biol Chem. 2009;284:27557-66 pubmed publisher
    ..Overall, these data delineate a key pathway by which TNF-alpha in a neuronal environment modulates IP(3)R expression and intracellular Ca(2+) homeostasis. ..
  91. Wang Y, Tu L, Li Y, Chen D, Liu Z, Hu X, et al. Notoginsenoside R1 Alleviates Oxygen-Glucose Deprivation/Reoxygenation Injury by Suppressing Endoplasmic Reticulum Calcium Release via PLC. Sci Rep. 2017;7:16226 pubmed publisher
    ..Recent evidence indicates that the Phospholipase C (PLC)/inositol 1,4,5-trisphosphate receptor (IP3R) is important for the regulation of Ca2+ release in the ER...
  92. Deelman L, Jonk L, Henning R. The isolation and characterization of the promoter of the human type 1 inositol 1,4,5-trisphosphate receptor. Gene. 1998;207:219-25 pubmed
    In humans, at least three types of inositol (1,4,5)-trisphosphate receptor (IP3R) are present. The gene encoding type 1 IP3R (IP3R-I) is expressed in all cell types, although expression predominates in Purkinje cells...