ITK

Summary

Gene Symbol: ITK
Description: IL2 inducible T-cell kinase
Alias: EMT, LPFS1, LYK, PSCTK2, tyrosine-protein kinase ITK/TSK, IL-2-inducible T-cell kinase, T-cell-specific kinase, homolog of mouse T-cell itk/tsk, interleukin-2-inducible T-cell kinase, kinase EMT, tyrosine-protein kinase LYK
Species: human

Top Publications

  1. ncbi Lck phosphorylates the activation loop tyrosine of the Itk kinase domain and activates Itk kinase activity
    S D Heyeck
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    J Biol Chem 272:25401-8. 1997
  2. pmc RIBP, a novel Rlk/Txk- and itk-binding adaptor protein that regulates T cell activation
    K Rajagopal
    Committee on Immunology, University of Chicago, Chicago, Illinois 60637, USA
    J Exp Med 190:1657-68. 1999
  3. ncbi Biochemical interactions integrating Itk with the T cell receptor-initiated signaling cascade
    S C Bunnell
    Department of Pathology, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    J Biol Chem 275:2219-30. 2000
  4. ncbi Regulatory intramolecular association in a tyrosine kinase of the Tec family
    A H Andreotti
    Howard Hughes Medical Institute, Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    Nature 385:93-7. 1997
  5. ncbi Interaction of SLP adaptors with the SH2 domain of Tec family kinases
    Y W Su
    Abteilung für Molekulare Immunologie Biologie III, Universität Freiburg und Max Planck Institut für Immunbiologie, Freiburg, Germany
    Eur J Immunol 29:3702-11. 1999
  6. pmc Deficiency of PTEN in Jurkat T cells causes constitutive localization of Itk to the plasma membrane and hyperresponsiveness to CD3 stimulation
    X Shan
    Laboratory of Biological Chemistry, Gerontology Research Center, National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224 6825, USA
    Mol Cell Biol 20:6945-57. 2000
  7. ncbi Identification of phosphorylation sites within the SH3 domains of Tec family tyrosine kinases
    Beston F Nore
    Karolinska Institutet, Clinical Research Center CRC at Novum, Huddinge University Hospital, SE 141 86, Huddinge, Sweden
    Biochim Biophys Acta 1645:123-32. 2003
  8. pmc The lymphoma-associated fusion tyrosine kinase ITK-SYK requires pleckstrin homology domain-mediated membrane localization for activation and cellular transformation
    Sue Rigby
    Division of Molecular Histopathology, Department of Pathology, University of Cambridge, Cambridge CB2 2QQ, United Kingdom
    J Biol Chem 284:26871-81. 2009
  9. ncbi Tec kinases mediate sustained calcium influx via site-specific tyrosine phosphorylation of the phospholipase Cgamma Src homology 2-Src homology 3 linker
    Lisa A Humphries
    Molecular Biology Institute and Department of Microbiology and Immunology, UCLA, Los Angeles, California 90095, USA
    J Biol Chem 279:37651-61. 2004
  10. ncbi Association of the Src homology 2 domain-containing leukocyte phosphoprotein of 76 kD (SLP-76) with the p85 subunit of phosphoinositide 3-kinase
    Eun Kyung Shim
    Division of Molecular Life Sciences and Center for Cell Signaling Research, Ewha Womans University, 11 1 Daehyun Dong, Seodaemun gu, Seoul 120 750, South Korea
    FEBS Lett 575:35-40. 2004

Research Grants

  1. The Role of LOX and LOXL1 in the Pathophysiology of Endometriosis
    PERLA MARIA BAEZ; Fiscal Year: 2010
  2. Judith A West-Mays; Fiscal Year: 2015
  3. KEVIN KEEWOUN KIM; Fiscal Year: 2016
  4. Thea D Tlsty; Fiscal Year: 2014
  5. Mechanisms of MMP-Induced Malignancy in Breast Cells
    Derek C Radisky; Fiscal Year: 2011
  6. Marcus E Peter; Fiscal Year: 2014
  7. David J Drasin; Fiscal Year: 2014
  8. The Role of Long Non-coding RNAs in EMT and Cancer Stem Cells
    Jason I Herschkowitz; Fiscal Year: 2013
  9. Steven N Steinway; Fiscal Year: 2015
  10. Ite A Laird-Offringa; Fiscal Year: 2015

Detail Information

Publications1022 found, 100 shown here

  1. ncbi Lck phosphorylates the activation loop tyrosine of the Itk kinase domain and activates Itk kinase activity
    S D Heyeck
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    J Biol Chem 272:25401-8. 1997
    The Tec family tyrosine kinase Itk has been implicated in T cell receptor (TCR) signaling, yet its precise role and mechanism of activation remain undefined...
  2. pmc RIBP, a novel Rlk/Txk- and itk-binding adaptor protein that regulates T cell activation
    K Rajagopal
    Committee on Immunology, University of Chicago, Chicago, Illinois 60637, USA
    J Exp Med 190:1657-68. 1999
    ..RIBP was also found to interact with a related member of the Tec family of tyrosine kinases, Itk. Expression of RIBP is restricted to T and natural killer cells and is upregulated substantially after T cell ..
  3. ncbi Biochemical interactions integrating Itk with the T cell receptor-initiated signaling cascade
    S C Bunnell
    Department of Pathology, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    J Biol Chem 275:2219-30. 2000
    b>Itk, a Tec family tyrosine kinase, acts downstream of Lck and phosphatidylinositol 3'-kinase to facilitate T cell receptor (TCR)-dependent calcium influxes and increases in extracellular-regulated kinase activity...
  4. ncbi Regulatory intramolecular association in a tyrosine kinase of the Tec family
    A H Andreotti
    Howard Hughes Medical Institute, Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    Nature 385:93-7. 1997
    The T-cell-specific tyrosine kinase Itk is a member of the Tec family of non-receptor tyrosine kinases, and is required for signalling through the T-cell antigen receptor (TCR)...
  5. ncbi Interaction of SLP adaptors with the SH2 domain of Tec family kinases
    Y W Su
    Abteilung für Molekulare Immunologie Biologie III, Universität Freiburg und Max Planck Institut für Immunbiologie, Freiburg, Germany
    Eur J Immunol 29:3702-11. 1999
    ..phosphorylation of phospholipase C-gamma isoforms by the Tec-related protein tyrosine kinase Btk in B cells and Itk in T cells...
  6. pmc Deficiency of PTEN in Jurkat T cells causes constitutive localization of Itk to the plasma membrane and hyperresponsiveness to CD3 stimulation
    X Shan
    Laboratory of Biological Chemistry, Gerontology Research Center, National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224 6825, USA
    Mol Cell Biol 20:6945-57. 2000
    ..Previously we found that the T-cell-specific PH domain-containing kinase Itk is constitutively membrane associated in Jurkat T cells...
  7. ncbi Identification of phosphorylation sites within the SH3 domains of Tec family tyrosine kinases
    Beston F Nore
    Karolinska Institutet, Clinical Research Center CRC at Novum, Huddinge University Hospital, SE 141 86, Huddinge, Sweden
    Biochim Biophys Acta 1645:123-32. 2003
    ..The major phosphorylation sites were identified as conserved tyrosines, for Itk Y180 and for Bmx Y215, both sites being homologous to the Y223 site in Btk...
  8. pmc The lymphoma-associated fusion tyrosine kinase ITK-SYK requires pleckstrin homology domain-mediated membrane localization for activation and cellular transformation
    Sue Rigby
    Division of Molecular Histopathology, Department of Pathology, University of Cambridge, Cambridge CB2 2QQ, United Kingdom
    J Biol Chem 284:26871-81. 2009
    b>ITK-SYK, a novel fusion tyrosine kinase (FTK) resulting from a recurrent t(5;9)(q33;q22), was recently identified in a poorly understood subset of peripheral T-cell lymphomas...
  9. ncbi Tec kinases mediate sustained calcium influx via site-specific tyrosine phosphorylation of the phospholipase Cgamma Src homology 2-Src homology 3 linker
    Lisa A Humphries
    Molecular Biology Institute and Department of Microbiology and Immunology, UCLA, Los Angeles, California 90095, USA
    J Biol Chem 279:37651-61. 2004
    ..Together, these data support a model whereby Btk/Tec kinases control sustained calcium signaling via site-specific phosphorylation of key residues within the PLCgamma2 SH2-SH3 linker...
  10. ncbi Association of the Src homology 2 domain-containing leukocyte phosphoprotein of 76 kD (SLP-76) with the p85 subunit of phosphoinositide 3-kinase
    Eun Kyung Shim
    Division of Molecular Life Sciences and Center for Cell Signaling Research, Ewha Womans University, 11 1 Daehyun Dong, Seodaemun gu, Seoul 120 750, South Korea
    FEBS Lett 575:35-40. 2004
    ..Collectively, these data suggest that SLP-76 may play a role in PI3K signaling pathways...
  11. ncbi A novel human tyrosine kinase gene inducible in T cells by interleukin 2
    N Tanaka
    Department of Microbiology, Tohoku University School of Medicine, Sendai, Japan
    FEBS Lett 324:1-5. 1993
    ..residue in the C-terminus classify this molecule into a new subfamily comprising recently cloned mouse tec, itk/tsk and human atk/bpk genes. This gene was transcriptionally induced in normal T cells by interleukin 2 stimulation...
  12. ncbi beta-cyclodextrin tetradecasulfate/tetrahydrocortisol +/- minocycline as modulators of cancer therapies in vitro and in vivo against primary and metastatic Lewis lung carcinoma
    B A Teicher
    Dana Farber Cancer Institute, Boston, MA 02115
    Cancer Chemother Pharmacol 33:229-38. 1993
    ..beta-cyclodextrin tetradecasulfate, and minocycline used alone or in combination are not very cytotoxic toward EMT-6 mouse mammary tumor cells growing in monolayer...
  13. ncbi Five-chlorodeoxycytidine and biomodulators of its metabolism result in fifty to eighty percent cures of advanced EMT-6 tumors when used with fractionated radiation
    S Greer
    Department of Microbiology and Immunology, University of Miami School of Medicine, FL 33101, USA
    Int J Radiat Oncol Biol Phys 32:1059-69. 1995
    ..The extent of control of the EMT-6 mammary adenocarcinoma was determined using fractionated radiation (12 irradiations) over a 3-week period using ..
  14. doi Epithelial-mesenchymal transition induced by biliary innate immunity contributes to the sclerosing cholangiopathy of biliary atresia
    Kenichi Harada
    Department of Human Pathology, Kanazawa University Graduate School of Medicine, Kanazawa, Japan
    J Pathol 217:654-64. 2009
    ..Epithelial-mesenchymal transition (EMT) has recently been proposed as a mechanism behind the sclerosing cholangitis in BA...
  15. ncbi In vivo efficacy of novel synthetic enediynes 1
    W Wrasidlo
    Department of Molecular and Experimental Medicine, Scripps Research Institute, La Jolla, CA 92037, USA
    Acta Oncol 34:157-64. 1995
    ..against L-1210 mouse leukemia, A549 lung carcinomas and PC3 prostate carcinomas in athymic nude mice, and against EMT-6 mouse mammary adenocarcinomas in Balb/cByJ mice...
  16. ncbi Transforming growth factor beta (TGFbeta) signalling in palatal growth, apoptosis and epithelial mesenchymal transformation (EMT)
    A Nawshad
    Department of Cell Biology, Harvard Medical School, 220 Longwood Ave, Goldensen Bldg, Room 342, Boston, MA 02115, USA
    Arch Oral Biol 49:675-89. 2004
    ..The MEE seam disappears by epithelial mesenchymal transformation (EMT), which creates confluence of connective tissue across the palate...
  17. ncbi Induction of hepatic haematopoiesis with fibronectin expression by EMT stromal cells during the second trimester of development
    M Lambropoulou
    Department of Histology Embryology, Democritus University of Thrace, Dragana, 68 100 Alexandroupolis, Greece
    Clin Exp Med 7:115-21. 2007
    ..been documented, but little is known about the effect of the foetal hepatic epithelial-to-mesenchymal transition (EMT) stromal cells' activity and their product-fibronectin, on foetal hepatic haematopoiesis...
  18. ncbi Epithelial-mesenchymal transformation in the embryonic heart is mediated through distinct pertussis toxin-sensitive and TGFbeta signal transduction mechanisms
    A S Boyer
    Department of Cell Biology and Anatomy, University of Arizona, Tucson 85724, USA
    Dev Dyn 214:81-91. 1999
    ..early development, progenitors of the heart valves and septa are formed by epithelial-mesenchymal transformation (EMT) of endothelial cells in the atrioventricular (AV) canal...
  19. ncbi Evaluating the evaluators: interrater reliability on EMT licensing examinations
    W Snyder
    Mercy Memorial Hospital, Monroe, MI 48162, USA
    Prehosp Emerg Care 2:37-46. 1998
    Current methods of evaluating the technical competence of Michigan emergency medical technician (EMT) licensure candidates are subjective and potentially unreliable...
  20. ncbi Histamine uptake by human endometrial cells expressing the organic cation transporter EMT and the vesicular monoamine transporter-2
    Vera Noskova
    Department of Obstetrics and Gynecology, Lund University Hospital, Lund, Sweden
    Mol Hum Reprod 12:483-9. 2006
    ..was used for detection of the organic cationic transporter-2 (OCT-2), the extraneuronal monoamine transporter (EMT), and VMAT-2 in cryosections of normal human endometrial tissue...
  21. pmc Detection of epithelial to mesenchymal transition in airways of a bleomycin induced pulmonary fibrosis model derived from an alpha-smooth muscle actin-Cre transgenic mouse
    Zhuang Wu
    Guangzhou Institute of Respiratory Disease, First Affiliated Hospital of Guangzhou Medical College, Guangzhou, 510120, PR China
    Respir Res 8:1. 2007
    Epithelial to mesenchymal transition (EMT) in alveolar epithelial cells (AECs) has been widely observed in patients suffering interstitial pulmonary fibrosis...
  22. ncbi Field trial of endotracheal intubation by basic EMTs
    M R Sayre
    Department of Emergency Medicine, University of Cincinnati, USA
    Ann Emerg Med 31:228-33. 1998
    The 1994 basic-EMT (EMT-B) curriculum recommended teaching EMT-Bs the skill of endotracheal intubation. In this study we assessed the success and complication rates of endotracheal intubations in the field by EMT-Bs.
  23. ncbi Albuterol sulfate administration by EMT-basics: results of a demonstration project
    David Markenson
    Program for Pediatric Preparedness, National Center for Disaster Preparedness, Mailman School of Public Health, Columbia University, New York, NY 10021, USA
    Prehosp Emerg Care 8:34-40. 2004
    1) To evaluate the ability to train emergency medical technicians-basic (EMT-Bs) to accurately identify bronchospasm and, based on a treatment protocol, administer albuterol sulfate via nebulization as a standing order...
  24. pmc Beta3 integrin and Src facilitate transforming growth factor-beta mediated induction of epithelial-mesenchymal transition in mammary epithelial cells
    Amy J Galliher
    UCHSC, Fitzsimons Campus, Department of Pharmacology, Mail Stop 8303, RC1 South Tower, Rm L18 6110, PO Box 6511, Aurora, CO 80045, USA
    Breast Cancer Res 8:R42. 2006
    ..The molecular mechanisms underlying this conversion of TGF-beta function remain poorly understood but may involve signaling inputs from integrins...
  25. ncbi Feasibility of basic emergency medical technicians to perform selected advanced life support interventions
    Francis X Guyette
    Department of Emergency Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Prehosp Emerg Care 10:518-21. 2006
    Emergency medical technician-basic (EMT-B) providers often provide the initial care to victims of out-of-hospital cardiac arrest...
  26. doi miR-200 expression regulates epithelial-to-mesenchymal transition in bladder cancer cells and reverses resistance to epidermal growth factor receptor therapy
    Liana Adam
    The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Clin Cancer Res 15:5060-72. 2009
    The epithelial-to-mesenchymal transition (EMT) is a cell development-regulated process in which noncoding RNAs act as crucial modulators...
  27. ncbi Outcomes of sudden cardiac arrest treated with defibrillation by emergency medical technicians (EMT-Ds) or paramedics in a two-tiered urban EMS system
    S M Joyce
    Division of Emergency Medicine, University of Utah School of Medicine, Salt Lake City, USA
    Prehosp Emerg Care 2:13-7. 1998
    Controversy exists as to the effectiveness of defibrillation by emergency medical technicians (EMT-Ds) in reducing mortality from cardiac arrest in two-tiered EMS systems...
  28. ncbi Prehospital pain management: a comparison of providers' perceptions and practices
    Halim Hennes
    Department of Pediatrics, Pediatric Emergency Medicine Section, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Prehosp Emerg Care 9:32-9. 2005
    To assess the knowledge of emergency medical technicians-paramedics (EMT-Ps) and compare their practice perceptions with actual pain management interventions in adults and pediatric patients (adolescents and children) with chest pain (CP)..
  29. doi Decreased expression of neurofibromin contributes to epithelial-mesenchymal transition in neurofibromatosis type 1
    Yoshimi Arima
    Division of Gene Regulation, Institute for Advanced Medical Research, School of Medicine, Keio University, Tokyo, Japan
    Exp Dermatol 19:e136-41. 2010
    ..of the Ras-mediated pathway, which has been shown to play a crucial role in epithelial-to-mesenchymal transition (EMT)...
  30. pmc Genes involved in TGF beta1-driven epithelial-mesenchymal transition of renal epithelial cells are topologically related in the human interactome map
    Stefano Campanaro
    CRIBI Biotechnology Center, Department of Biology, University of Padova, Italy
    BMC Genomics 8:383. 2007
    ..cells (HUTEC) under different TGF beta 1 concentrations we had observed epithelial-to-mesenchymal transition (EMT) but not epithelial-myofibroblast transdifferentiation...
  31. ncbi A nationwide prehospital stroke survey
    T J Crocco
    Department of Emergency Medicine, University of Cincinnati, Ohio 45267 0769, USA
    Prehosp Emerg Care 3:201-6. 1999
    ..To identify deficiencies in stroke knowledge among prehospital providers...
  32. doi Modulation of several waves of gene expression during FGF-1 induced epithelial-mesenchymal transition of carcinoma cells
    Clotilde Billottet
    CNRS UMR 144 Institut Curie, 26 Rue d Ulm, 75248 Paris Cedex 05, France
    J Cell Biochem 104:826-39. 2008
    During epithelial-mesenchymal transition (EMT), epithelial cells are converted into isolated motile and invasive mesenchymal cells...
  33. doi Unique expression pattern of the EMT markers Snail, Twist and E-cadherin in benign and malignant parathyroid neoplasia
    Volker Fendrich
    Department of Surgery, Philipps University Marburg, Marburg, Germany
    Eur J Endocrinol 160:695-703. 2009
    Epithelial and mesenchymal transitions (EMT) are essential for embryonic development and progression of non-invasive tumor cells into malignant, metastatic carcinomas...
  34. ncbi Dento-alveolar and maxillofacial injuries - a survey of knowledge of the regimental aid providers in the Israeli army
    Liran Levin
    Department of Oral Rehabilitation, The Maurice and Gabriela Goldschleger School of Dental Medicine, Tel Aviv University, Tel Aviv, Israel
    Dent Traumatol 23:243-6. 2007
    The present study evaluated the knowledge of physicians and emergency medical technicians (EMT) regarding primary treatment for oral and maxillofacial trauma and assessed the experience they have in treating oral and maxillofacial ..
  35. ncbi Teaching ACLS stroke objectives to prehospital providers: a case-based approach
    Todd J Crocco
    University of Cincinnati, Department of Emergency Medicine, Cincinnati, Ohio, USA
    Prehosp Emerg Care 7:229-34. 2003
    ....
  36. ncbi Endotracheal tube placement by EMT-Basics in a rural EMS system
    Jeffrey C Pratt
    Tisbury Ambulance Service, Tisbury, Martha s Vineyard, MA, USA
    Prehosp Emerg Care 9:172-5. 2005
    To evaluate the effectiveness of an intubation-training module and special-waiver project in which Emergency Medical Technician (EMT)-Basics were trained to perform endotracheal intubations in a rural community.
  37. doi Erythropoietin suppresses epithelial to mesenchymal transition and intercepts Smad signal transduction through a MEK-dependent mechanism in pig kidney (LLC-PK1) cell lines
    Chien Liang Chen
    Division of Nephrology, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan
    Exp Cell Res 316:1109-18. 2010
    ..growth factor-beta1 (TGF-beta1) plays a pivotal role in processes like kidney epithelial-mesenchymal transition (EMT) and interstitial fibrosis, which correlate well with progression of renal disease...
  38. ncbi Laminin-5 with transforming growth factor-beta1 induces epithelial to mesenchymal transition in hepatocellular carcinoma
    G Giannelli
    Department of Internal Medicine, Immunology, and Infectious Diseases, Section of Internal Medicine, University of Bari Medical School, Bari, Italy
    Gastroenterology 129:1375-83. 2005
    ..HCC) cells acquire the ability to invade surrounding tissue is unknown, but epithelial mesenchymal transition (EMT) likely plays a role...
  39. ncbi Role of Wnt/beta-catenin signaling pathway in epithelial-mesenchymal transition of human prostate cancer induced by hypoxia-inducible factor-1alpha
    Yong Guang Jiang
    Department of Urology, Affiliated Beijing Anzhen Hospital of Capital Medical University, Anzhenli Street, Chaoyang District, Beijing, China
    Int J Urol 14:1034-9. 2007
    Epithelial-mesenchymal transition (EMT) is an important process in tumor development, and several studies suggest that the Wnt/beta-catenin signal pathway may play an important role in EMT...
  40. doi Left atrial electromechanical conduction time can predict six-month maintenance of sinus rhythm after electrical cardioversion in persistent atrial fibrillation by Doppler tissue echocardiography
    Seong Mi Park
    Division of Cardiology, Korea University College of Medicine, Seoul, Korea
    J Am Soc Echocardiogr 23:309-14. 2010
    The purpose of this study was to determine whether atrial electromechanical conduction time (EMT) measured by echocardiography can predict 6-month maintenance of sinus rhythm (SR) after electrical cardioversion in patients with atrial ..
  41. ncbi Determinants of intra versus intermolecular self-association within the regulatory domains of Rlk and Itk
    Alain Laederach
    Department of Chemical Engineering, Iowa State University, Ames, IA 50010, USA
    J Mol Biol 329:1011-20. 2003
    ..This is in contrast to the corresponding fragment of Itk, for which the proline-rich ligand/SH3 interaction occurs exclusively in an intramolecular fashion and no ..
  42. ncbi Evaluation of possible tourniquet systems for use in the Canadian Forces
    Roger B King
    Residency Program, University of Alberta, Edmonton, Alberta, Canada
    J Trauma 60:1061-71. 2006
    ..The purpose of this trial was to determine which tourniquet systems are effective under simulated combat conditions and make recommendations to the Canadian Forces (CF) on an approach to tourniquet use...
  43. ncbi Sustained TGF beta exposure suppresses Smad and non-Smad signalling in mammary epithelial cells, leading to EMT and inhibition of growth arrest and apoptosis
    A Gal
    Ludwig Institute for Cancer Research, Uppsala, Sweden
    Oncogene 27:1218-30. 2008
    ..after exposure to TGFbeta for 2-5 days, whereas surviving cells underwent epithelial-mesenchymal transition (EMT)...
  44. pmc Murine cirrhosis induces hepatocyte epithelial mesenchymal transition and alterations in survival signaling pathways
    Takashi Nitta
    Department of Surgery, Division of General and Gastrointestinal GI Surgery, University of Florida, Gainesville, FL, USA
    Hepatology 48:909-19. 2008
    ..In fetal hepatocytes, TGFbeta also induces epithelial-mesenchymal transition (EMT) and signaling changes in cell survival pathways...
  45. doi BMP-7 fails to attenuate TGF-beta1-induced epithelial-to-mesenchymal transition in human proximal tubule epithelial cells
    Paul L Dudas
    Department of Immunology Research, Centocor Research and Development, Inc, 145 King of Prussia Road, R 4 2, Radnor, PA 19087, USA
    Nephrol Dial Transplant 24:1406-16. 2009
    ..showed that BMP-7 was renoprotective by antagonizing TGF-beta1-stimulated epithelial-to-mesenchymal transition (EMT)...
  46. pmc Epithelial-to-mesenchymal transition of peritoneal mesothelial cells is regulated by an ERK/NF-kappaB/Snail1 pathway
    Raffaele Strippoli
    Integrin Signaling Laboratory, Department of Vascular Biology and Inflammation, Centro Nacional de Investigaciones Cardiovasculares CNIC, Melchor Fernandez Almagro 3, 28029 Madrid, Spain
    Dis Model Mech 1:264-74. 2008
    Epithelial-to-mesenchymal transition (EMT) occurs in fibrotic diseases affecting the kidney, liver and lung, and in the peritoneum of patients undergoing peritoneal dialysis...
  47. pmc Site-dependent differences in clinical, pathohistological, and molecular parameters in metastatic colon cancer
    Christoph Wilmanns
    Dept of General Surgery, University of Freiburg, FRG
    Int J Biol Sci 5:458-65. 2009
    ..and molecular markers potentially reflecting oncogenic activation (OA) or epithelial-mesenchymal transition (EMT), where OA may reflect an activation and EMT the functional loss of certain genes...
  48. pmc Staurosporine augments EGF-mediated EMT in PMC42-LA cells through actin depolymerisation, focal contact size reduction and Snail1 induction - a model for cross-modulation
    Honor J Hugo
    Embryology Laboratory, Murdoch Children s Research Institute, Royal Children s Hospital, Parkville, Australia
    BMC Cancer 9:235. 2009
    A feature of epithelial to mesenchymal transition (EMT) relevant to tumour dissemination is the reorganization of actin cytoskeleton/focal contacts, influencing cellular ECM adherence and motility...
  49. doi Epithelial-mesenchymal transition induced by transforming growth factor-beta1 in mouse tracheal epithelial cells
    Shigeki Kuroishi
    Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka, Japan
    Respirology 14:828-37. 2009
    Epithelial-mesenchymal transition (EMT) is the process by which differentiated epithelial cells undergo a phenotypic transition to mesenchymal cells. This process may occur in certain fibrotic diseases that involve airway remodelling...
  50. doi Effect of emergency medical technician-placed Combitubes on outcomes after out-of-hospital cardiopulmonary arrest
    Charles E Cady
    Department of Emergency Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Prehosp Emerg Care 13:495-9. 2009
    While emergency medical technicians-basic (EMT-Bs) in select emergency medical services (EMS) agencies use the Esophageal Tracheal Combitube (ETC) for the airway management of out-of-hospital cardiopulmonary arrests, the effect of this ..
  51. pmc Identification of epithelial to mesenchymal transition as a novel source of fibroblasts in intestinal fibrosis
    Sarah N Flier
    Division of Matrix Biology, Dept of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Center for Life Science, 3 Blackfan Circle, Rm 11090, Boston, MA 02215, USA
    J Biol Chem 285:20202-12. 2010
    ..Here, we evaluated the contribution of epithelial to mesenchymal transition (EMT) to intestinal fibrosis associated with a mouse model of CD and also human inflammatory bowel disease...
  52. doi Vimentin expression is associated with decreased survival in gastric cancer
    Sho Otsuki
    Department of Surgical Oncology, Tokyo Medical and Dental University, 1 5 45, Yushima, Bunkyo, Tokyo 113 8519, Japan
    Oncol Rep 25:1235-42. 2011
    ..The expression of mesenchymal markers such as vimentin is observed after epithelial-mesenchymal transition (EMT), an important initial behavioral change related to the adhesion and migration properties of tumor cells that is ..
  53. ncbi Results of a 4-hour endotracheal intubation class for EMT-basics
    B Larmon
    University of California at Los Angeles Emergency Medical Center, University of California at Los Angeles School of Medicine, USA
    Ann Emerg Med 31:224-7. 1998
    In 1994, the Department of Transportation made endotracheal intubation an optional EMT-Basic skill. To data, there have been no studies addressing the ability of this group to learn or perform this skill...
  54. doi Epithelial-mesenchymal transition in breast cancer relates to the basal-like phenotype
    David Sarrio
    Breast and Gynecological Cancer Group, Molecular Pathology Programme, Centro Nacional de Investigaciones Oncologicas, Madrid, Spain
    Cancer Res 68:989-97. 2008
    Epithelial-mesenchymal transition (EMT) is defined by the loss of epithelial characteristics and the acquisition of a mesenchymal phenotype...
  55. ncbi ZEB proteins link cell motility with cell cycle control and cell survival in cancer
    Gareth Browne
    Department of Cancer Studies and Molecular Medicine, University of Leicester, Leicester, UK
    Cell Cycle 9:886-91. 2010
    Epithelial mesenchymal transitions (EMT), the generation of motile mesenchymal cells from epithelial sheets, are differentiation programs which take place at several critical steps of embryonic development and in metastatic cancer...
  56. doi Continuously perfused, non-cross-contaminating microfluidic chamber array for studying cellular responses to orthogonal combinations of matrix and soluble signals
    Edward S Park
    School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, Atlanta, GA, USA
    Lab Chip 10:571-80. 2010
    ..of alveolar epithelial type II (ATII) cells, particularly the extent of epithelial-to-mesenchymal transition (EMT), a highly suspected pathway in tissue regeneration and fibrosis...
  57. doi Immunization with a recombinant GnRH vaccine fused to heat shock protein 65 inhibits mammary tumor growth in vivo
    Xue Jun Wang
    Key Laboratory of Human Functional Genomics of Jiangsu Province, Nanjing Medical University, Hanzhong Road 140, Nanjing, 210029, China
    Cancer Immunol Immunother 59:1859-66. 2010
    ..Moreover, the growth of EMT-6 mammary tumor allografts was inhibited by anti-GnRH antibodies...
  58. doi CD49f-based selection of circulating tumor cells (CTCs) improves detection across breast cancer subtypes
    Bianca Mostert
    Erasmus MC, Department of Medical Oncology, Daniel den Hoed Cancer Center and Laboratory of Translational Tumor Immunology, Groene Hilledijk 301, 3075 EA Rotterdam, The Netherlands
    Cancer Lett 319:49-55. 2012
    ..using CellSearch, but not all breast cancer subtypes, specifically those with epithelial-mesenchymal transition (EMT) characteristics, sufficiently express the enrichment (EpCAM) and selection (CK8/18/19) markers used in this method...
  59. doi A novel 2-pyrone derivative, BHP, impedes oncogenic KRAS-driven malignant progression in breast cancer
    Rae Kwon Kim
    Department of Chemistry, Research Institute for Natural Sciences, Hanyang University, Seoul 133 791, Republic of Korea
    Cancer Lett 337:49-57. 2013
    ..with BHP effectively suppressed the migratory and invasive properties along with epithelial-mesenchymal transition (EMT) in MDA-MB231 breast cancer cells that carry oncogenic KRAS and mesenchymal malignant phenotypes...
  60. pmc Discovery of novel irreversible inhibitors of interleukin (IL)-2-inducible tyrosine kinase (Itk) by targeting cysteine 442 in the ATP pocket
    John D Harling
    From the Allergic Inflammation Discovery Performance Unit and
    J Biol Chem 288:28195-206. 2013
    IL-2-inducible tyrosine kinase (Itk) plays a key role in antigen receptor signaling in T cells and is considered an important target for anti-inflammatory drug discovery...
  61. doi Resemble and Inhibit: when RLR meets TGF-β
    Shu Zhu
    Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA
    Mol Cell 56:719-20. 2014
    ..2014) show that innate antiviral RIG-I-like receptors (RLR) signaling represses TGF-β-induced growth inhibition, epithelial-mesenchyme transition (EMT), and regulatory T cell (Treg) differentiation via IRF3-mediated Smads function.
  62. pmc miR-200c regulates crizotinib-resistant ALK-positive lung cancer cells by reversing epithelial-mesenchymal transition via targeting ZEB1
    Hai Xiang Gao
    Department of Oncology, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei 050011, P R China
    Mol Med Rep 14:4135-4143. 2016
    ..and suppression of miR‑200c expression, the characteristics associated with epithelial‑mesenchymal transition (EMT), including morphology, EMT marker proteins and cellular mobility, were investigated...
  63. ncbi Positive feedback regulation of PLCgamma1/Ca(2+) signaling by PKCtheta in restimulated T cells via a Tec kinase-dependent pathway
    Amnon Altman
    Division of Cell Biology, La Jolla Institute for Allergy and Immunology, San Diego, CA 92121, USA
    Eur J Immunol 34:2001-11. 2004
    ..In addition, wild-type Tec, but not Itk or Rlk, potently activated AP-1...
  64. ncbi Human TIM-1 associates with the TCR complex and up-regulates T cell activation signals
    Lauri L Binné
    Biogen Idec, 12 Cambridge Center, Cambridge, MA 02142, USA
    J Immunol 178:4342-50. 2007
    ..TIM-1 expression induces formation of a novel complex that includes PI3K and ITK. Finally, the consequences of TIM-1 activation include increased expression of effector cytokines...
  65. ncbi Krüppel-like factor 8 induces epithelial to mesenchymal transition and epithelial cell invasion
    Xianhui Wang
    Center for Cell Biology and Cancer Research, Albany Medical College, Albany, New York 12208, USA
    Cancer Res 67:7184-93. 2007
    Tumor invasion and metastasis are the main causes of death from cancer. Epithelial to mesenchymal transition (EMT) is a determining step for a cancer cell to progress from a noninvasive to invasive state...
  66. ncbi Transforming growth factor-beta induces epithelial to mesenchymal transition by down-regulation of claudin-1 expression and the fence function in adult rat hepatocytes
    Takashi Kojima
    Department of Pathology, Sapporo Medical University School of Medicine, Sapporo, Japan
    Liver Int 28:534-45. 2008
    Transforming growth factor-beta (TGF-beta) initiates and maintains epithelial-mesenchymal transition (EMT), which causes disassembly of tight junctions and loss of epithelial cell polarity...
  67. doi Redox mechanisms switch on hypoxia-dependent epithelial-mesenchymal transition in cancer cells
    Stefania Cannito
    Dipartamento di Medicina e Oncologia Sperimentale and Centro Interuniversitario di Fisiopatologia Epatica, University of Torino, Torino, Italy
    Carcinogenesis 29:2267-78. 2008
    Epithelial-mesenchymal transition (EMT) and hypoxia are considered as crucial events favouring invasion and metastasis of many cancer cells...
  68. pmc MEKK3 initiates transforming growth factor beta 2-dependent epithelial-to-mesenchymal transition during endocardial cushion morphogenesis
    Mark V Stevens
    Department of Pharmacology and Toxicology, University of Arizona, Tucson, AZ 85721, USA
    Circ Res 103:1430-40. 2008
    ..hearts before, during, and after cardiac cushion cells have executed epithelial-to-mesenchymal transition (EMT)...
  69. doi Cellular senescence: hot or what?
    Gerard I Evan
    Department of Pathology and Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA 94143 0502, USA
    Curr Opin Genet Dev 19:25-31. 2009
    ..More recently, the discovery that cellular senescence can be bypassed during the epithelial-mesenchymal transition (EMT) that typically accompanies tumor progression, the observation that organ fibrosis is controlled by cellular ..
  70. doi The role of ZEB1 in the inflammation-induced promotion of EMT in HNSCC
    Mariam Dohadwala
    Jonsson Comprehensive Cancer Center, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Otolaryngol Head Neck Surg 142:753-9. 2010
    To determine the role of ZEB1 in the inflammation-induced promotion of the epithelial-mesenchymal transition (EMT) in head and neck squamous cell carcinoma (HNSCC).
  71. pmc Differential roles of IL-2-inducible T cell kinase-mediated TCR signals in tissue-specific localization and maintenance of skin intraepithelial T cells
    Mingcan Xia
    Department of Veterinary and Biomedical Sciences, Center for Molecular Immunology and Infectious Disease, Pennsylvania State University, University Park, PA 16802, USA
    J Immunol 184:6807-14. 2010
    ..In this study, we identified IL-2-inducible T cell kinase (ITK) as a critical signal molecule regulating the acquirement of the skin-homing property by the fetal thymic sIEL ..
  72. pmc The epithelial-mesenchymal transition (EMT) phenomenon
    P Savagner
    IRCM U896 INSERM, CRLC Val d Aurelle Paul Lamarque, Montpellier, France
    Ann Oncol 21:vii89-92. 2010
    The epithelial-mesenchymal transition (EMT) describes a rapid and often reversible modulation of phenotype by epithelial cells...
  73. pmc The origin of interstitial myofibroblasts in chronic kidney disease
    Ivica Grgic
    Renal Division, Brigham and Women s Hospital, Harvard Institutes of Medicine Rm 550, Boston, MA 02115, USA
    Pediatr Nephrol 27:183-93. 2012
    ..thought to directly contribute to the myofibroblast pool by the process of epithelial-to-mesenchymal transition (EMT)...
  74. pmc Multiscale imaging characterization of dopamine transporter knockout mice reveals regional alterations in spine density of medium spiny neurons
    M L Berlanga
    National Center for Microscopy and Imaging Research, Center for Research in Biological Systems, University of California, San Diego, La Jolla, CA 92093 0608, USA
    Brain Res 1390:41-9. 2011
    ..the dendrite where spine density is reported to be the highest, were analyzed using electron microscope tomography (EMT)...
  75. pmc Hedgehog activity, epithelial-mesenchymal transitions, and biliary dysmorphogenesis in biliary atresia
    Alessia Omenetti
    Division of Gastroenterology, Duke University Medical Center, Durham, NC, USA
    Hepatology 53:1246-58. 2011
    ..Hh-neutralizing antibody to determine direct effects of Hh ligands on epithelial to mesenchymal transition (EMT) marker expression. Livers from pediatric controls showed greater innate Hh activation than adult controls...
  76. doi Endothelial mesenchymal transformation mediated by IL-1β-induced FGF-2 in corneal endothelial cells
    Jeong Goo Lee
    Doheny Eye Institute, Keck School of Medicine of the University of Southern California, Los Angeles, CA, USA
    Exp Eye Res 95:35-9. 2012
    This review describes the molecular mechanism of endothelial mesenchymal transformation (EMT) mediated by fibroblast growth factor-2 (FGF-2) in corneal endothelial cells (CECs)...
  77. doi Inhibitors of interleukin-2 inducible T-cell kinase as potential therapeutic candidates for the treatment of various inflammatory disease conditions
    Maninder Kaur
    Molecular Modeling Lab MML, Department of Pharmaceutical Sciences and Drug Research, Punjabi University, Patiala, Punjab 147002, India
    Eur J Pharm Sci 47:574-88. 2012
    Interleukin-2 inducible T-cell kinase (ITK), a member of Tec family of non-receptor protein tyrosine kinases plays a domineering role in the T-cell development, differentiation and production of pro-inflammatory cytokines such as IL-2, ..
  78. doi Snail1 is involved in de novo cardiac fibrosis after myocardial infarction in mice
    Yajie Liu
    Department of Cardiology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China
    Acta Biochim Biophys Sin (Shanghai) 44:902-10. 2012
    Epithelial-mesenchymal transition (EMT) is an important mechanism of cardiac fibrosis after myocardial infarction (MI). However, it remains unclear whether Snail1, an important regulator of EMT, is involved in cardiac fibrosis...
  79. pmc Fibroblast growth factor receptors-1 and -3 play distinct roles in the regulation of bladder cancer growth and metastasis: implications for therapeutic targeting
    Tiewei Cheng
    Department of Urology, The University of Texas M D Anderson Cancer Center, Houston, TX, USA
    PLoS ONE 8:e57284. 2013
    ..The results suggest that the tumor EMT phenotype will be an important determinant of the biological effects of FGFR inhibitors in patients.
  80. pmc The collagen receptor discoidin domain receptor 2 stabilizes SNAIL1 to facilitate breast cancer metastasis
    Kun Zhang
    BRIGHT Institute, Washington University, St Louis, Missouri 63110, USA
    Nat Cell Biol 15:677-87. 2013
    ..DDR2 maintains SNAIL1 level and activity in tumour cells that have undergone epithelial-mesenchymal transition (EMT), thereby facilitating continued tumour cell invasion through collagen-I-rich extracellular matrices by sustaining ..
  81. doi Secreted products of macrophages exposed to calcium oxalate crystals induce epithelial mesenchymal transition of renal tubular cells via RhoA-dependent TGF-β1 pathway
    Rattiyaporn Kanlaya
    Medical Proteomics Unit, Office for Research and Development, Faculty of Medicine Siriraj Hospital, and Center for Research in Complex Systems Science, Mahidol University, 6th Floor, SiMR Building, 2 Prannok Road, Bangkoknoi, Bangkok, 10700, Thailand
    Cell Biochem Biophys 67:1207-15. 2013
    ..secretion of fibrotic factors from macrophages leading to "epithelial mesenchymal transition/transdifferentiation" (EMT) of renal tubular cells...
  82. doi Epithelial-mesenchymal transition increases during the progression of in situ to invasive basal-like breast cancer
    Yoomi Choi
    Department of Pathology, Seoul National University College of Medicine, Seoul, 110 799, Korea
    Hum Pathol 44:2581-9. 2013
    Epithelial-mesenchymal transition (EMT) is known to play an important role in breast cancer invasion and metastatic progression...
  83. doi Emodin represses TWIST1-induced epithelial-mesenchymal transitions in head and neck squamous cell carcinoma cells by inhibiting the β-catenin and Akt pathways
    Tzong Der Way
    Department of Biological Science and Technology, College of Life Sciences, China Medical University, Taichung, Taiwan Department of Health and Nutrition Biotechnology, College of Health Science, Asia University, Taichung, Taiwan Electronic address
    Eur J Cancer 50:366-78. 2014
    ..of metastatic traits and tumour-initiating abilities in cancer cells during the epithelial-mesenchymal transition (EMT)...
  84. pmc Rabconnectin-3a regulates vesicle endocytosis and canonical Wnt signaling in zebrafish neural crest migration
    Adam M Tuttle
    Department of Developmental and Cell Biology, University of California, Irvine, California, United States of America
    PLoS Biol 12:e1001852. 2014
    ..crest (NC) cells in vertebrates are highly migratory cells, which undergo an epithelial-mesenchymal transition (EMT) to leave the neural epithelium and migrate throughout the body to give rise to many different derivatives...
  85. doi Gain-of-function of mutant p53: mutant p53 enhances cancer progression by inhibiting KLF17 expression in invasive breast carcinoma cells
    Amjad Ali
    Institute of Biomedical Sciences, School of Life Sciences, East China Normal University, 500 Dongchuan Road, Shanghai, 200241, China Electronic address
    Cancer Lett 354:87-96. 2014
    Kruppel-like-factor 17 (KLF17) is a negative regulator of metastasis and epithelial-mesenchymal-transition (EMT). However, its expression is downregulated in metastatic breast cancer that contains p53 mutations...
  86. pmc Down-regulation of 5-HT1B and 5-HT1D receptors inhibits proliferation, clonogenicity and invasion of human pancreatic cancer cells
    Nilgun Gurbuz
    Department of Experimental Therapeutics, The University of Texas, M D Anderson Cancer Center, Houston, Texas, United States of America
    PLoS ONE 9:e105245. 2014
    ..finger ZEB1 and Snail proteins, the hallmarks transcription factors regulating epithelial-mesenchymal transition (EMT), concomitantly with up-regulating of claudin-1 and E-Cadherin...
  87. pmc The novel Aryl hydrocarbon receptor inhibitor biseugenol inhibits gastric tumor growth and peritoneal dissemination
    De Wei Lai
    Institute of Biomedical Sciences, National Chung Hsing University, Taichung, Taiwan
    Oncotarget 5:7788-804. 2014
    ..Snail expression, through AhR activation, is an epithelial-to-mesenchymal transition (EMT) determinant...
  88. pmc The kinase LYK5 is a major chitin receptor in Arabidopsis and forms a chitin-induced complex with related kinase CERK1
    YangRong Cao
    Division of Plant Sciences, National Center for Soybean Biotechnology, University of Missouri, Columbia, United States
    elife 3:. 2014
    Chitin is a fungal microbe-associated molecular pattern recognized in Arabidopsis by a lysin motif receptor kinase (LYK), AtCERK1...
  89. doi Fibulin-3 negatively regulates ALDH1 via c-MET suppression and increases γ-radiation-induced sensitivity in some pancreatic cancer cell lines
    In Gyu Kim
    Department of Radiation Biology, Environmental Radiation Research Group, Korea Atomic Energy Research Institute, 989 111 Daedeok daero, Yuseong Gu, Daejeon 305 353, Republic of Korea Department of Radiation Biotechnology and Applied Radioisotope, Korea University of Science and Technology UST, 989 111 Daedeok daero, Yusong gu, Daejeon 305 353, Republic of Korea Electronic address
    Biochem Biophys Res Commun 454:369-75. 2014
    ..cytotoxic agents such as γ-radiation and strongly inhibited the stemness and epithelial to mesenchymal transition (EMT) property of pancreatic cancer cells...
  90. pmc Pancreatic cancer metastasis: are we being pre-EMTed?
    Srustidhar Das
    Department of Biochemistry and Molecular Biology, Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, 985870 Nebraska Medical Center, Omaha, NE 68198 5870, U S A
    Curr Pharm Des 21:1249-55. 2015
    ..pancreatic cancer to understand the dynamics of tumor cell dissemination and epithelial to mesenchymal transition (EMT) of tumor cells well before the primary tumor is formed...
  91. doi Sorcin Enhances Metastasis and Promotes Epithelial-to-Mesenchymal Transition of Colorectal Cancer
    Weihua Tong
    Department of Gastrointestinal Colorectal Surgery, First Hospital of Jilin University, 71th Xin Min Street, Changchun, 130021, Jilin, China
    Cell Biochem Biophys 72:453-9. 2015
    ..Sorcin-induced changes in EMT process were evaluated by estern blot...
  92. pmc Modulation of the cancer cell transcriptome by culture media formulations and cell density
    Seung Wook Kim
    Department of Cancer Biology, Metastasis Research Laboratory, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Int J Oncol 46:2067-75. 2015
    ..Genes associated with epithelial‑mes-enchymal transition (EMT) were among the genes that were differentially modulated by cells grown in different cell culture formulations and ..
  93. ncbi Sorafenib inhibits migration and invasion of hepatocellular carcinoma cells through suppression of matrix metalloproteinase expression
    Tae Yong Ha
    Department of Surgery, University of Ulsan College of Medicine, Seoul, Republic of Korea
    Anticancer Res 35:1967-76. 2015
    ..receptor tyrosine kinase activity, but involvement of sorafenib in fibrosis and epithelial-mesenchymal transition (EMT) remains unclear...
  94. pmc Epithelial-mesenchymal transition in keratocystic odontogenic tumor: possible role in locally aggressive behavior
    Wen Qun Zhong
    State Key Laboratory Breeding Base of Basic Science of Stomatology Hubei MOST and Key Laboratory of Oral Biomedicine Ministry of Education, School and Hospital of Stomatology, Wuhan University, 237 Luoyu Road, Wuhan 430079, China
    Biomed Res Int 2015:168089. 2015
    The aim of this study is to clarify whether epithelial-mesenchymal transition (EMT) is involved in the pathogenesis and development of keratocystic odontogenic tumor (KCOT)...
  95. pmc Hsa-miR-19a is associated with lymph metastasis and mediates the TNF-α induced epithelial-to-mesenchymal transition in colorectal cancer
    Lanlan Huang
    Guangdong Institute of Gastroenterology and the Sixth Affiliated Hospital
    Sci Rep 5:13350. 2015
    ..Although epithelial-to-mesenchymal transition (EMT), TNF-α and microRNA (miRNA) have been found to play important roles in lymph node metastasis, the underlying ..
  96. pmc Acquired resistance to 5-fluorouracil via HSP90/Src-mediated increase in thymidylate synthase expression in colon cancer
    Ji Young Ahn
    College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul 151 742, Republic of Korea
    Oncotarget 6:32622-33. 2015
    ..colon cancer cells morphologic, molecular, and behavioral characteristic of the epithelial-mesenchymal transition (EMT), contributing to emergence of acquired resistance to 5-FU...
  97. doi Sanguiin H6 suppresses TGF-β induction of the epithelial-mesenchymal transition and inhibits migration and invasion in A549 lung cancer
    Hyeonseok Ko
    Laboratory of Molecular Oncology, Cheil General Hospital and Women s Healthcare Center, Dankook University College of Medicine, Seoul, South Korea
    Bioorg Med Chem Lett 25:5508-13. 2015
    In the epithelial-mesenchymal transition (EMT), an important cellular process, epithelial cells become mesenchymal cells. This process is also critically involved in cancer metastasis...
  98. doi Differentiation of first trimester cytotrophoblast to extravillous trophoblast involves an epithelial-mesenchymal transition
    Sonia DaSilva-Arnold
    Department of Obstetrics and Gynecology, Center for Abnormal Placentation, Hackensack University Medical Center, Hackensack, NJ, USA
    Placenta 36:1412-8. 2015
    ..The process of EVT differentiation has several factors in common with the epithelial-to-mesenchymal transition (EMT) observed in embryonic development, wound healing and cancer metastasis...
  99. doi Peptide microarray patterning for controlling and monitoring cell growth
    Edith Lin
    Department of Chemistry, University of Alberta, Edmonton, Alberta T6G 2G2, Canada
    Acta Biomater 34:53-9. 2016
    ..As a model, we used a murine mammary gland cell line (NMuMG) that undergoes epithelial to mesenchymal transition (EMT) in response to soluble transforming growth factor beta (TGF-β) and surface-immobilized peptides that target TGF-β..
  100. pmc PS341 inhibits hepatocellular and colorectal cancer cells through the FOXO3/CTNNB1 signaling pathway
    Zhao Yang
    Department of Oncology, The First Affiliated Hospital of Soochow University, Suzhou, 215006, China
    Sci Rep 6:22090. 2016
    ..CRC both in vitro and in vivo, including the inhibition of cell proliferation, epithelial-mesenchymal transition (EMT), the expression of stemness-related genes, cell migration and invasiveness...
  101. pmc Elevated expression of flotillin-1 is associated with lymph node metastasis and poor prognosis in early-stage cervical cancer
    Zheng Li
    Department of Gynecologic Oncology, The Third Affiliated Hospital of Kunming Medical University Yunnan Tumor Hospital 519 Kunzhou Road, Kunming 650118, China
    Am J Cancer Res 6:38-50. 2016
    ..affected cervical cancer cell motility and invasion, respectively, through epithelial-mesenchymal transition (EMT) regulated by the Wnt/β-catenin and nuclear factor-κB (NF-κB) pathways...

Research Grants112 found, 100 shown here

  1. The Role of LOX and LOXL1 in the Pathophysiology of Endometriosis
    PERLA MARIA BAEZ; Fiscal Year: 2010
    ..Recently, LOX isoforms have been identified as new players in the regulation of epithelial-mesenchymal transition (EMT), a mechanism whereby cancer cells become migratory and invasive...
  2. Judith A West-Mays; Fiscal Year: 2015
    Epithelial-mesenchymal transition (EMT) has been shown to play an important role in the fibroses of multiple organs and tissues, including the ocular lens, where it contributes to both anterior subcapsular cataracts (ASC) and posterior ..
  3. KEVIN KEEWOUN KIM; Fiscal Year: 2016
    ..cells are capable of transitioning into fibroblast-like cells in a process of epithelial-mesenchyma transition (EMT)...
  4. Thea D Tlsty; Fiscal Year: 2014
    ..system where epigenetically-plastic cells are exposed to factors that induce epithelial-to- mesenchymal transition (EMT), an important malignant program...
  5. Mechanisms of MMP-Induced Malignancy in Breast Cells
    Derek C Radisky; Fiscal Year: 2011
    ..MMP-dependent production of ROS causes cells to undergo epithelial-mesenchymal transition (EMT), a fundamental phenotypic alteration associated with progression to metastasis, and compromises the cellular ..
  6. Marcus E Peter; Fiscal Year: 2014
    ..MiR-200 family members suppress ZEB1 and ZEB2, two transcription factors known to be powerful EMT inducers through suppression of the expression of E-cadherin...
  7. David J Drasin; Fiscal Year: 2014
    DESCRIPTION (provided by applicant): The epithelial-to-mesenchymal transition (EMT) is a cellular program in which epithelial cells gain mesenchymal characteristics and lose epithelial traits, which can result in increased motility and ..
  8. The Role of Long Non-coding RNAs in EMT and Cancer Stem Cells
    Jason I Herschkowitz; Fiscal Year: 2013
    ..junction genes, including claudin 3 and E-cadherin, and higher expression of epithelial to mesenchymal transition (EMT) associated genes. We recently found that claudin-low tumors are enriched for functional CSCs...
  9. Steven N Steinway; Fiscal Year: 2015
    ..Epithelial-to-mesenchymal transition (EMT) is a process initiated during liver development that is utilized by liver cancer cells to initiate metastatic ..
  10. Ite A Laird-Offringa; Fiscal Year: 2015
    ..cells arise from alveolar epithelial cells (AEC), through the process of epithelial-to-mesenchymal transition (EMT). Numerous observations point to a key role for AEC in the initiation and development of IPF...
  11. CHEMOPREVENTION WITH GREEN TEA POLYPHENON E (PPE) AND EGFR-TKIs IN HEAD AND NECK
    DONG MOON SHIN; Fiscal Year: 2011
    ..cell surface localization of E- cadherin, suggesting that they may inhibit epithelial to mesenchymal transition (EMT) of the malignant epithelial cells...
  12. Yibin Kang; Fiscal Year: 2014
    ..miR-200 family and the miR-194/192 cluster of miRNAs as negative regulators of epithelial-mesenchymal transition (EMT), which is thought to be the critical initiating step of cancer metastasis...
  13. Celina G Kleer; Fiscal Year: 2016
    ..that inhibition of CCN6 in benign breast epithelial cells causes an epithelial to mesenchymal transition (EMT) with marked down regulation of E-cadherin...
  14. Richard A Anderson; Fiscal Year: 2014
    ..provided by applicant): A hallmark of epithelial cancer progression is the epithelia to mesenchymal transition (EMT)...
  15. Regulation of p120-catenin tumor supressor activities
    DOUGLAS STAIRS; Fiscal Year: 2010
    ..and it is speculated that this may be another mechanism by which E-cadherin expression may be lost and lead to EMT. Functionally, we have demonstrated that successful genetic knockdown of p120ctn results in loss of the integrity ..
  16. Analysis of Alveolar Type II cells in Normal and Fibrotic Human Lung
    Paul J Wolters; Fiscal Year: 2012
    ..The role of candidate genes that promote epithelial to mesenchymal transition (EMT) of IPF Type II cells will be confirmed in an in vitro assay of EMT...
  17. Regulation of p120-catenin tumor supressor activities
    DOUGLAS STAIRS; Fiscal Year: 2013
    ..and it is speculated that this may be another mechanism by which E-cadherin expression may be lost and lead to EMT. Functionally, we have demonstrated that successful genetic knockdown of p120ctn results in loss of the integrity ..
  18. Ruth A Keri; Fiscal Year: 2015
    ..discerning mechanism(s) that control epithelial/mesenchymal properties and epithelial to mesenchymal transition (EMT) should provide significant insights into the processes that contribute to metastatic disease...
  19. Claudia D Andl; Fiscal Year: 2016
    ..hypothesis for this study is that Act A signaling is a major regulator of epithelial-mesenchymal transition (EMT) and epithelial-mesenchymal crosstalk in the esophagus...
  20. Molecular regulation of breast cancer growth
    Marsha A Moses; Fiscal Year: 2010
    ..We have recently demonstrated that the overexpression of NGAL in human breast cancer cells induces an EMT (Epithelial to Mesenchymal Transformation), a hallmark of cancer progression...
  21. Yvonne M W Janssen-Heininger; Fiscal Year: 2016
    ..of TGF-[unreadable]1, in association with the causation of a mesenchymal transition of airway epithelial cells (EMT)...
  22. WILLIAM SCHIEMANN; Fiscal Year: 2016
    ..will provide valuable information on how TGF-?, integrins, and mechanotransduction cooperate in promoting the EMT, invasion, and metastasis of TNBCs, and more importantly, on how to control these deadly processes by inactivating ..
  23. ROBERT DANIEL BEAUCHAMP; Fiscal Year: 2016
    ..Through these insights, we expect to identify novel targets for therapeutic intervention. ..
  24. Sem H Phan; Fiscal Year: 2016
    ..suggest additional derivation from epithelial cells through a process termed epithelial-mesenchymal transition (EMT)...
  25. KOY Y SAETEURN; Fiscal Year: 2015
    ..cells to acquire invasive, mesenchymal characteristics, a process known as epithelial-mesenchymal transition (EMT)...
  26. A novel function of TIMP-1
    Hyeong Reh Choi Kim; Fiscal Year: 2012
    ..Moreover, TIMP-1 interaction with CD63 induces an epithelial mesenchymal transition (EMT) via upregulation of the EMT master transcription factor Twist, known to promote cancer progression...
  27. Shilpa Vyas-Read; Fiscal Year: 2014
    ..from the exciting preliminary data that reactive oxygen species (ROS) induce epithelial-to-mesenchymal transition (EMT) in alveolar epithelial cells and that antioxidants, such as glutathione, can attenuate this transition...
  28. Creation of adult epithelial stem cells from differentiated epithelial
    Robert A Weinberg; Fiscal Year: 2010
    ..Our strategy is to re-activate a latent developmental program, termed the Epithelial-Mesenchymal Transition (EMT)...
  29. Personalized therapeutics for inhibiting breast cancer metastasis
    DEBRA AUGUSTE; Fiscal Year: 2012
    ..In addition, lipocalin-2 (Lcn2) has been shown to induce the epithelial to mesenchymal transition (EMT)...
  30. Signaling Pathways in Stages of Tumorigenesis
    Gail E Sonenshein; Fiscal Year: 2012
    ..Wnt pathway, resulting from environmental carcinogen exposure, contributes to epithelial to mesenchymal transition (EMT), which promotes tumor cell invasion and metastasis...
  31. Cellular Repair of Kidney Injury
    Lloyd G Cantley; Fiscal Year: 2010
    ..has emerged that suggests that this process may instead lead to true epithelial-mesenchymal transformation (EMT), thereby promoting fibrosis and preventing repair...
  32. David D Tran; Fiscal Year: 2016
    ..Although the Epithelial-Mesenchymal Transition (EMT) has been implicated in the initial stages of cancer metastasis, how it is maintained in late metastatic cells and ..
  33. Global programs of ESRP-regulated splicing in renal development and function
    RUSS PAUL CARSTENS; Fiscal Year: 2012
    ..Our studies suggest that they play a key role in the epithelial to mesenchymal transition (EMT) and mesenchymal to epithelial transition (MET)...
  34. Richard M Peek; Fiscal Year: 2016
    ..Another p120-mediated response linked to carcinogenesis is epithelial-to-mesenchymal transition (EMT), which is dependent upon a switch in expression of p120 isoforms...
  35. Dissecting the Transcriptional Network of Twist Mediated Metastasis
    ANDREW THOMAS CHANG; Fiscal Year: 2011
    ..A cellular program named epithelial-mesenchymal transition (EMT) is shown to be vital process in initiating dissemination of primary tumor cells to form metastatic lesions...
  36. Jihe Zhao; Fiscal Year: 2014
    ..b>EMT (epithelial to mesenchymal transition) is a determining step for a cancer cell to progress from a non-invasive to ..
  37. Robert A Weinberg; Fiscal Year: 2016
    ..This conversion is often termed an epithelial-mesenchymal transition (EMT) and, when appropriated by carcinoma cells, serves to impart to these cells critical powers, such as invasiveness ..
  38. William E Lawson; Fiscal Year: 2015
    ..Recent studies reveal that AECs may directly contribute to fibrosis through epithelial-mesenchymal transition (EMT). Further, hyperplastic type II AECs line fibrotic areas, raising questions about their role in remodeling...
  39. Regulation of tumorigenesis by alternative pre-mRNA splicing
    DANEEN L SCHAEFFER; Fiscal Year: 2012
    ..with epithelial plasticity will be expressed in epithelial cells that have been artificially induced to undergo EMT and become mesenchymal...
  40. EMT, Extravasation and metastasis by N-Cadherin signaling
    Rachel B Hazan; Fiscal Year: 2013
    ..These are hallmarks of epithelial to mesenchymal transition (EMT) associated with metastatic progression...
  41. SNAIL-Dependent Regulation of EMT in Cancer
    STEPHEN JOSEPH WEISS; Fiscal Year: 2010
    ..of E-cadherin expression is a hallmark of a key developmental program termed the epithelial-mesenchymal transition (EMT), a process often exploited by cancer cells that display an invasive phenotype...
  42. The effect of Wnt pathway signaling in NSCLC
    Robert Winn; Fiscal Year: 2009
    ..is to define signaling pathways that control oncogenic transformation and epithelial to mesenchymal transition (EMT) of lung cancer cells...
  43. Epithelial Plasticity and Epithelial to Mesenchymal Transition
    Andrew D Robertson; Fiscal Year: 2010
    ..Epithelial to mesenchymal transition (EMT) is a basic cellular process in which epithelial cells lose epithelial properties, e.g...
  44. Thomas W Bebee; Fiscal Year: 2014
    ..The process of epithelial to mesenchymal transition (EMT) and the reverse process of MET have been extensively studied at the transcriptional level, while only recently has ..
  45. Differentiation of Alveolar Epithelium in Pulmonary Fibrosis
    Philip L Sannes; Fiscal Year: 2010
    ..to attempt to achieve differentiation by producing more TGF2, which not only sustains the problem but promotes EMT and more fibrosis...
  46. Bobak Parang; Fiscal Year: 2015
    ..Epithelial-to-mesenchymal transition (EMT) is a critical process by which epithelial cells acquire more mesenchymal phenotypes, such as greater motility and ..
  47. STRAP and Smad 7 Signaling in Colorectal Carcinomas
    Pran K Datta; Fiscal Year: 2013
    ..Our preliminary data suggest that STRAP induces epithelial-to-mesenchymal transition (EMT) by deregulating E-cadherin independently of TGF-[unreadable]...
  48. Angela L Tyner; Fiscal Year: 2016
    ..Our preliminary data indicate that knockdown of PTK6 promotes the epithelial mesenchymal transition (EMT) in human colon tumor cell lines, suggesting that PTK6 is important for maintenance of the epithelial phenotype in ..
  49. Kamal A Mohammed; Fiscal Year: 2014
    ..Furthermore, HO-1 deficiency is known to promote EMT in renal fibrosis4 and HO-1 induction prevented pulmonary fibrosis in animal models5...
  50. Beiyun Zhou; Fiscal Year: 2016
    ..in turn induce AEC apoptosis and/or giving rise directly to fibroblasts through epithelial-mesenchymal transition (EMT)...
  51. Acetaldehyde and Epithelial Junctions: Role of PP2A and Occludin Phosphorylation
    MITZI LEE DUNAGAN; Fiscal Year: 2011
    ..My second specific aim is to determine that acetaldehyde induces epithelial-to-mesenchymal transition(EMT) by a PP2A-dependent mechanism...
  52. Discovering Microenvironments Promoting Pathological EMT using Array Technology
    Naira Serobyan; Fiscal Year: 2012
    ..Recent studies have linked cancer metastasis to the improper reactivation of epithelial-mesenchymal transition (EMT)...
  53. Ragini Vittal; Fiscal Year: 2015
    ..of the inflammatory molecule, IL-17 (interleukin-17), in the induction of epithelial-mesenchymal transition (EMT)...
  54. Prevalence of CD24 epigenetic silencing in breast tumors and ERalpha status
    Benny Abraham Kaipparettu; Fiscal Year: 2012
    ..Similarly epithelial mesenchymal transition (EMT) in human mammary epithelial cells resulted in CD24 negative phenotype with enriched tumor-initiating and ..
  55. Arjang Djamali; Fiscal Year: 2015
    ..a) Nox2 is inducible in renal tubular epithelial cells during CsA-induced epithelial-to-mesenchymal transition (EMT) (b) tubulointerstitial Nox2 is upregulated in kidneys undergoing CsA-induced fibrosis (c) inhibition of Nox ..
  56. Timothy S Blackwell; Fiscal Year: 2015
    ..and increased accumulation of fibroblasts, including fibroblasts derived via epithelial-mesenchymal transition (EMT)...
  57. SARAH NICOLE FLIER; Fiscal Year: 2015
    ..diseases of organs including the kidney, liver and heart is a process termed Epithelial to Mesenchymal Transition (EMT)...
  58. ANDREW THOMAS SCHIFFMACHER; Fiscal Year: 2015
    ..NCCs are a transient population of migratory cells that undergo an epithelial-to-mesenchymal transition (EMT) to acquire motility, migrate throughout the whole embryo and then differentiate into a diverse range of cell types ..
  59. Driss Zoukhri; Fiscal Year: 2015
    ..a mesenchymal stem cell (MSC) phenotype are generated through induction of epithelial-to-mesenchymal transition (EMT)...
  60. GUSTAVO ADOLFO MIRANDA-CARBONI; Fiscal Year: 2014
    ..lung metastasis tumors cells with mesenchymal stem-cell properties express epithelial-to- mesenchymal transition (EMT) markers featuring high expression of HMGA2 and factors critical for metastatic colonization...
  61. Gail E Sonenshein; Fiscal Year: 2014
    ..Oncogenic Her-2/neu induces epithelial to mesenchymal transition (EMT) and this was reverted by LOX-PP...
  62. Seema Khurana; Fiscal Year: 2016
    DESCRIPTION (provided by applicant): Epithelial-mesenchymal transition (EMT) is a highly conserved cellular program that allows polarized, immotile epithelial cells to convert to motile mesenchymal cells...
  63. Binhua P Zhou; Fiscal Year: 2016
    ..BLBC intrinsically possesses many epithelial-mesenchymal transition (EMT) characteristics and cancer stem cell (CSC)-like features, suggesting that activation of EMT program generates high-..
  64. Harold A Chapman; Fiscal Year: 2014
    ..in their invasiveness and matrix production a process termed epithelial to mesenchymal-like transitions (EMT)...
  65. TGF-Beta Signaling Effectors in Prostate Growth Regulation/Tumor Progression
    Natasha Kyprianou; Fiscal Year: 2013
    ..interaction between TGF-[unreadable]1 and androgens towards apoptosis and epithelial to mesenchymal transition (EMT) of prostate tumor epithelial cells...
  66. Epithelial-mesenchymal Transition in the Pathogenesis of Pulmonary Fibrosis
    William E Lawson; Fiscal Year: 2010
    ..and transition of epithelial cells to a fibroblast phenotype, a process termed epithelial-mesenchymal transition (EMT)...
  67. Role of IKK in NSCLC: Modulation of SMRT and NF-kappaB
    Marty W Mayo; Fiscal Year: 2012
    ..for stimulating a morphogenesis within carcinoma cells referred to as epithelial to mesenchymal transition (EMT). EMT is believed to be essential to carcinoma progression by stimulating invasion and metastasis...
  68. WILLIAM TSWENCHING PU; Fiscal Year: 2016
    ..Furthermore, epicardial cells undergo epithelial to mesenchymal transition (EMT), generating epicardium-derived mesenchymal cells (EPDCs) that migrate into the heart and differentiate into ..
  69. ELAINE LYNETTE WILSON; Fiscal Year: 2016
    ..KD of KLF4 and JUNB induced epithelial-mesenchymal transition (EMT)...
  70. Panayotis Pantazis; Fiscal Year: 2014
    ..This heterogeneity is further complicated by epithelial-mesenchymal transition (EMT), a process that plays a key role in cancer invasion and metastasis...
  71. Ivo Teneng; Fiscal Year: 2014
    ..DNMT3b will be exposed to tobacco carcinogens, and the effect on time to transformation, transformation efficiency, EMT and growth in nude mice will be determined...
  72. Leland W K Chung; Fiscal Year: 2016
    ..Results showed significant correlation of LIV-1 (p<0.001), a driver of epithelial to mesenchymal transition (EMT), cytoplasmic but not nuclear BDNF (p<0.001), ?2-M (p=0.006), focal adhesion kinase (FAK) (p=0...
  73. HEATHER JOY RAY; Fiscal Year: 2015
    DESCRIPTION (provided by applicant): The epithelial-to-mesenchymal (EMT) transition plays an essential role during embryonic development. Studies have also found that EMT can be involved in the promotion of various epithelial cancers...
  74. International EMT meeting
    RAYMOND BRUCE RUNYAN; Fiscal Year: 2013
    ..investigators in the separate disciplines of cancer, pathology and development to discuss their observations on EMT and explore whether there is a consensus on important components of the process. 2...
  75. Oxidative activation of Src in smoke-induced epithelial mesenchymal transition
    Henry Jay Forman; Fiscal Year: 2013
    ..and other electrophiles in cigarette smoke activate Src kinase, which precedes epithelial-mesenchymal transition (EMT)...
  76. Frank B Gertler; Fiscal Year: 2016
    ..in vivo imaging are broad, we focus here on monitoring the critical steps of epithelial to mesenchymal transition (EMT) and back-MET...
  77. Xin Li; Fiscal Year: 2016
    ..of Suv39H1 by metformin to suppress prostate cancer cell growth and epithelial- mesenchymal transition (EMT)...
  78. Michael Y Sherman; Fiscal Year: 2014
    ..and mouse mammary epithelium, (2) p21 in addition to senescence can regulate epithelium mesenchymal transition (EMT) via controlling expression of the transcription factor SNAIL, and (3) in the mouse model Her2-mediated ..
  79. KRYSTAL DOLE NOLAN; Fiscal Year: 2015
    ..Metastatic progression is commonly associated with initiation of the epithelial to mesenchymal transition (EMT) developmental genetic program...
  80. The Utility of Empiric Medical Treatment of Infertile Oligo-asthenospermic Men
    Peter R Casson; Fiscal Year: 2013
    ..Empiric medical treatment (EMT) treatment with either clomiphene citrate (CC;a selective estrogen receptor modulator) or letrozole (an aromatase ..
  81. Functions of Epithelial Splicing Regulatory Proteins and their role in the EMT
    RUSS PAUL CARSTENS; Fiscal Year: 2013
    ..Expression of both ESRP1 and ESRP2 is turned off during the Epithelial Mesenchymal Transition (EMT) and therefore we will also investigate the role of ESRP downregulation and the corresponding changes in splicing ..
  82. Luzhe Sun; Fiscal Year: 2016
    ..we will investigate their PD properties and their effects on TGF? - regulated immune suppression, angiogenesis, and EMT. The secondary objective of Aim 2 is to determine whether the fusions interfere with TGF?'s tumor suppressive ..
  83. Role of TGF beta receptor III localization in breast cancer progression
    ALISON MEYER; Fiscal Year: 2013
    ..cell polarity is often lost during cancer progression, which may be mediated by epithelial-mesenchymal transition (EMT). Interestingly, the EMT process is triggered by TGF- and inhibited by T RIII in breast epithelial cells...
  84. Therapeutic Strategy for LAM (Lymphangioleiomyomatosis)
    TONY EISSA; Fiscal Year: 2013
    ..It has been suggested that LAM cells undergo epithelial-mesenchymal transition (EMT). Src kinases are key regulators of cellular proliferation, motility, invasiveness and EMT...
  85. Jianfei Qi; Fiscal Year: 2015
    ..it triggers H3K9 demethylation and facilitates HIF-mediated transcription of Slug and ZEB2 that in turn induces the EMT program. ChIP-on-chip and microarray analyses are proposed to study global role of Jmjd1a for EMT gene expression...
  86. Elizabeth Tarasewicz; Fiscal Year: 2014
    ..or treat cells with CDK4 or JNK inhibitors, and assess for Smad3-dependent markers of cell cycle control and EMT by mRNA and protein analysis...
  87. Liangyou Rui; Fiscal Year: 2015
    ..Snail2 is a transcriptional regulator believed to promote epithelial-to-mesenchymal transition (EMT) in development and cancer metastasis...
  88. Does Teamwork Mediate Relationship between Partner Familiarity and EMT Injuries?
    PAUL D PATTERSON; Fiscal Year: 2013
    ..Similar research in EMS does not exist. We hypothesize that fatal and non-fatal EMT injuries occur more frequently among less familiar partners and among partners that fail to engage in positive ..
  89. Thymic adipogenesis and age-related thymic demise
    Vishwa Deep Dixit; Fiscal Year: 2013
    ..with advancing age transition of FoxN1+ cells into adipogenic precursors via epithelial-mesenchymal transition (EMT) process gives rise to ectopic thymic adipocytes and compromises the thymic stromal microenvironment...
  90. ROBERT ANDREW WINN; Fiscal Year: 2014
    ..NSCLC, and that the loss of Wnt 7a and/or Fzd 9 is strongly associated with epithelial to mesenchymal transition (EMT), loss of cellular polarity, and increased susceptibility to lung carcinogenesis in mice...
  91. Kelli E Valdez; Fiscal Year: 2014
    ..of cells within breast cancer lesions which appear to drive metastasis and epithelial-mesenchymal transition (EMT)...
  92. Andrew P Feinberg; Fiscal Year: 2016
    ..Furthermore, the LOCKs are dynamically reprogrammed during epithelial-mesenchymal transition (EMT), which is critical for cancer progression...
  93. Aura Ganz; Fiscal Year: 2015
    ..rescue operations, enable post forensic analysis of the incident and rescue operations, provides data valuable to EMT training purposes, enable the hospitals to prepare for the arrival of patients, thus improving hospitals'..
  94. Role of FGFR1 signaling in distinct cell lineages in prostate cancer progresssion
    Michael M Ittmann; Fiscal Year: 2013
    ..demonstrated that ectopic FGFR1 signaling in prostate epithelium results in an epithelial-mesenchymal transition (EMT)-associated carcinoma, and conditional knockout of FGFR1 results in decreased primary tumor growth...
  95. Tien Hsu; Fiscal Year: 2015
    ..Our studies in the past funding period have elucidated a novel epithelial-to-mesenchymal transition (EMT) pathway that has been implicated in kidney injury and fibrosis...
  96. Pravin C Singhal; Fiscal Year: 2014
    ..only showed activation of the mTOR pathway but also displayed enhanced epithelial mesenchymal transdifferentiation (EMT)...
  97. Array Microscope Assay for Cancer Cell Mechanics
    Richard Superfine; Fiscal Year: 2013
    ..We will assess dynamic changes in biomechanical properties during epithelial- mesenchymal transition (EMT), and investigate the migratory, invasive and metastatic potential of these cell models both in vitro (cell lines) ..
  98. Richard O Hynes; Fiscal Year: 2015
    ..tumor stroma" will be investigated as will be the mechanisms of their effects on the tumor cells - induction of EMT, acquisition of stem-cell-like properties, migration, invasion, intravasation and extravasation and formation of ..
  99. Fazlul H Sarkar; Fiscal Year: 2015
    ..Emerging evidence suggests that acquisition of the epithelial-to-mesenchymal transition (EMT), a process that resembles the genesis of cancer stem-like cells, contributes to tumor aggressiveness and is ..
  100. Impacts of Alcohol / Fatigue on Paramedic Skills
    LES BECKER; Fiscal Year: 2001
    ..routine levels of fatigue and alcohol hangover among certified practicing Emergency Medical Technician-Paramedics (EMT-Ps) can be found to impair judgment and/or performance in such a way that patients who are reliant on the medical ..
  101. Endocrine Status of MG Stroma Alters Breast CA Invasion
    Pepper Schedin; Fiscal Year: 2004
    ..propose that these involution-associated changes in mammary stroma promote an epithelial to mesenchymal transition (EMT) in pre-existing neoplastic cells...